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Scientific Literature, organic anion transport
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Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.
J. Biol. Chem. 274: 17159-17163 (1999).
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Adachi T, Nakagawa H, Hagiya Y, Yasuoka T, Ishikawa T. Transport-metabolism interplay: LXR-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Mol. Pharm. 6: 1678-1688 (2009).
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Adachi Y, Kamisako T. Intrahepatic cholestasis.
Nippon Rinsho 54: 788-793 (1996).
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Adachi Y, Kamisako T, Okuyama Y, Miya H. Hepatic metabolism and transport of bilirubin and other organic anions.
Nippon Rinsho 54: 2276-2290 (1996).
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Akashi M, Tanaka A, Takikawa H. Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats.
Hepatol. Res. 34: 193-198 (2006).
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Aleksandrov AA, Aleksandrov LA, Riordan JR. CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.
Pflugers Arch. 453: 693-702 (2007).
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Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications.
Pharm. Res. 24: 1803-1823 (2007).
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Andrejko KM, Raj NR, Kim PK, Cereda M, Deutschman CS. IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters.
Shock 29: 490-496 (2008).
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Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge.
J. Pharmacol. Sci. 100: 411-426 (2006).
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Aoki K, Saso N, Kato S, Sugiyama Y, Sato H. Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
Biol. Pharm. Bull. 31: 1882-1887 (2008).
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Arrese M, Trauner M. Molecular aspects of bile formation and cholestasis.
Trends Mol. Med. 9: 558-564 (2003).
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Asif AR, Ljubojevic M, Sabolic I, Shnitsar V, Metten M, Anzai N, Mueller GA, Burckhardt G, Hagos Y. Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEAS treatment in adrenocortical cells.
Am. J. Physiol. Endocrinol. Metab. 291: E1351-E1359 (2006).
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Aslamkhan AG, Thompson DM, Perry JL, Bleasby K, Wolff NA, Barros S, Miller DS, Pritchard JB. The flounder organic anion transporter fOat has sequence, function and substrate specificity similarity to both mammalian Oat1 and Oat3.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1773-R1780 (2006).
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Augustine LM, Markelewicz RJ Jr, Boekelheide K, Cherrington NJ. Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier.
Drug Metab. Dispos. 33: 182-189 (2005).
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Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Interaction of methotrexate with OATP1A2 and its genetic variants.
J. Pharmacol. Exp. Ther. 318: 521-529 (2006).
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Bahn A, Ebbinghaus C, Ebbinghaus D, Ponimaskin EG, Fuzesi L, Burckhardt G, Hagos Y. Expression studies and functional characterization of renal human organic anion transporter 1 isoforms.
Drug Metab. Dispos. 32: 424-430 (2004).
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Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G. Identification of a new urate and high affinity nicotinate transporter - human organic anion transporter 10 (hOAT10, SLC22A13).
J. Biol. Chem. 283: 16332-16341 (2008).
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Bahn A, Hagos Y, Rudolph T, Burckhardt G. Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport.
Biochimie 86: 133-136 (2004).
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Baier PK, Hempel S, Waldvogel B, Baumgartner U. Zonation of hepatic bile salt transporters.
Dig. Dis. Sci. 51: 587-593 (2006).
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Ballatori N. Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta.
Exp. Biol. Med. (Maywood) 230: 689-698 (2005).
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Ballatori N, Hammond CL, Cunningham JB, Krance SM, Marchan R. Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins.
Toxicol. Appl. Pharmacol. 204: 238-255 (2005).
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Ballatori N, Henson JH, Seward DJ, Cai SY, Runnegar M, Fricker G, Miller DS, Boyer JL. Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis.
Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 144: 167-179 (2006).
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Barros SA, Srimaroeng C, Perry JL, Walden R, Dembla-Rajpal N, Sweet DH, Pritchard JB. Activation of protein kinase C zeta increases OAT1 (SLC22A6) and OAT3 (SLC22A8)-mediated transport.
J. Biol. Chem. 284: 2672-2679 (2009).
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Bergasa NV. The pruritus of cholestasis.
J. Hepatol. 43: 1078-1088 (2005).
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Beringer PM, Kriengkauykiat J, Zhang X, Hidayat L, Liu S, Louie S, Synold T, Burckart GJ, Rao PA, Shapiro B, Gill M. Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis.
Pharmacotherapy 28: 883-894 (2008).
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Beuers U. Mechanisms of action of ursodeoxycholic acid in cholestasis.
Falk Symposium 136. XII FALK LIVER WEEK 2003 (Part I) In Honour of Hans Popper’s 100th Birthday. Cholestatic Liver Diseases: Therapeutical Options and Perspectives. Freiburg (Germany). p. 49-50. October 15-16 (2003). *
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Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver.
Hepatology 33: 1206-1216 (2001).
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Beukeveld GJ, In 't Veld G, Havinga R, Groen AK, Wolthers BG, Kuipers F. Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport.
J. Hepatol. 24: 343-352 (1996).
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Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).
J. Hum. Genet. 51: 575-580 (2006).
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Bjornsson E, Chapman RW. Sclerosing cholangitis.
Curr. Opin. Gastroenterol. 19: 270-275 (2003).
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Bloomer J, Wang Y, Singhal A, Risheg H. Molecular studies of liver disease in erythropoietic protoporphyria.
J. Clin. Gastroenterol. 39: S167-S175 (2005).
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Bock HH, Lammert F. Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense.
Hepatology 35: 232-234 (2002).
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Bodo A, Bakos E, Szeri F, Varadi A, Sarkadi B. Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions.
J. Biol. Chem. 278: 23529-23537 (2003).
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Bolder U, Jeschke MG, Landmann L, Wolf F, de Sousa C, Schlitt HJ, Przkora R. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms.
Cell Stress Chaperones 11: 89-100 (2006).
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Bolder U, Thasler WE, Hofmann AF, Jauch KW. Hepatocellular transport of bile acids and organic anions in infection and SIRS - evidence for different mechanisms for regulating membrane transport proteins.
Langenbecks Arch. Chir. Suppl. Kongressbd. 115 (Suppl. I): 391-396 (1998).
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Bolder U, Ton-Nu HT, Schteingart CD, Frick E, Hofmann AF. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion.
Gastroenterology 112: 214-225 (1997).
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Bolder U, Trang NV, Hagey LR, Schteingart CD, Ton-Nu HT, Cerre C, Elferink RP, Hofmann AF. Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats.
Gastroenterology 117: 962-971 (1999).
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Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins.
J. Natl. Cancer Inst. 92: 1295-1302 (2000).
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Boyer JL. Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?
Gastroenterology 129: 735-740 (2005).
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Boyer JL, Denk G, Bohan A, Chen WS, Soroka C, Denson L. Adaptive regulation of bile salt transporters in cholestasis.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 46-47. June 18-19 (2004). *
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Brandoni A, Anzai N, Kanai Y, Endou H, Torres AM. Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3.
Biochim. Biophys. Acta 1762: 673-682 (2006).
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Brandoni A, Torres AM. Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.
J. Histochem. Cytochem. 57: 449-456 (2009).
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Brandoni A, Villar SR, Picena JC, Anzai N, Endou H, Torres AM. Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction.
Hepatology 43: 1092-1100 (2006).
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Breen CM, Sykes DB, Baehr C, Fricker G, Miller DS. Fluorescien-methotrexate transport in rat choroid plexus analyzed using confocal microscopy.
Am. J. Physiol. Renal Physiol. 287: F562-F569 (2004).
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Briz O, Romero MR, Martinez-Becerra P, Macias RI, Perez MJ, Jimenez F, San Martin FG, Marin JJ. OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?
J. Biol. Chem. 281: 30326-30335 (2006).
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Capuano P, Bacic D, Stange G, Hernando N, Kaissling B, Pal R, Kocher O, Biber J, Wagner CA, Murer H. Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1.
Pflugers Arch. 449: 392-402 (2005).
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Cha SH, Lee WK, Kwak JO, Hwang JS, Suh CK. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients.
Mol. Cells 25: 265-271 (2008).
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Chae HW, Kim IW, Jin HE, Kim DD, Chung SJ, Shim CK. Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine.
Arch. Pharm. Res. 31: 103-110 (2008).
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Chandra P, Brouwer KL. The complexities of hepatic drug transport: current knowledge and emerging concepts.
Pharm. Res. 21: 719-735 (2004).
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Chandra P, Johnson BM, Zhang P, Pollack GM, Brouwer KL. Modulation of hepatic canalicular or basolateral transport alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.
Drug Metab. Dispos. 33: 1238-1243 (2005).
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Chen BC, Kuo KK, Chen YH, Liu CH, Tsai LY, Hsu HK, Hsu C. Retinoid X receptor alpha participation in dexamethasone induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
Shock 32: 164-171 (2009).
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Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD. Activation of cyclic AMP (cAMP)-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 (Oatp2) expression.
Mol. Pharmacol. 71: 1159-1164 (2007).
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Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Tseng HC, Jeng YM, Chang MH. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.
Pediatr. Res. 63: 667-673 (2008).
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Chen J, Raymond K. Treatment effect of rifampicin on cholestasis.
The Internet Journal of Pharmacology Vol. 4 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol4n2/colestasis.xml) (2006). *
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Chen J, Terada T, Ogasawara K, Katsura T, Inui KI. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.
Am. J. Physiol. Renal Physiol. 295: F247-F252 (2008).
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Cheng X, Klaassen CD. Critical role of PPARalpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced down-regulation of Oatp uptake transporters in mouse livers.
Toxicol. Sci. 106: 37-45 (2008).
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Cheng X, Maher JM, Dieter MZ, Klaassen CD. Regulation of mouse organic anion transporting polypeptides (Oatps) in liver by prototypical microsome enzyme inducers that activate distinct transcription factor pathways.
Drug Metab. Dispos. 33: 1276-1282 (2005).
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Cheng X, Maher JM, Lu H, Klaassen CD. Endocrine regulation of gender-divergent mouse organic anion transporting polypeptide (Oatp) expression.
Mol. Pharmacol. 70: 1291-1297 (2006).
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Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.
Drug Metab. Dispos. 32: 734-741 (2004).
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Chiang JY. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.
J. Hepatol. 40: 539-551 (2004).
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Chignard N, Mergey M, Veissiere D, Parc R, Capeau J, Poupon R, Paul A, Housset C. Bile acid transport and regulating functions in the human biliary epithelium.
Hepatology 33: 496-503 (2001).
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Choudhuri S, Cherrington NJ, Li N, Klaassen CD. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats.
Drug Metab. Dispos. 31: 1337-1345 (2003).
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Chu X, Bleasby K, Yabut J, Cai X, Chan GH, Hafey MJ, Xu S, Bergman AJ, Braun MP, Dean DC, Evers R. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human renal transporters hOAT3, OATP4C1, and MDR1 P-glycoprotein.
J. Pharmacol. Exp. Ther. 321: 673-683 (2007).
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Clerici C, Castellani D, Asciutti S, Pellicciari R, Setchell KD, O'Connell NC, Sadeghpour B, Camaioni E, Fiorucci S, Renga B, Nardi E, Sabatino G, Clementi M, Giuliano V, Baldoni M, Orlandi S, Mazzocchi A, Morelli A, Morelli O. 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats.
Toxicol. Appl. Pharmacol. 214: 199-208 (2006).
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Cole SP, Deeley RG. Transport of glutathione and glutathione conjugates by MRP1.
Trends Pharmacol. Sci. 27: 438-446 (2006).
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Conseil G, Deeley RG, Cole SP. Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.
Pharmacogenet. Genomics 15: 523-533 (2005).
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Conseil G, Deeley RG, Cole SP. Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1).
J. Biol. Chem. 281: 43-50 (2006).
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Couvert P, Giral P, Dejager S, Gu J, Huby T, Chapman MJ, Bruckert E, Carrie A. Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.
Pharmacogenomics 9: 1217-1227 (2008).
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Cui T, Liu Y, Men X, Xu Z, Wu L, Liu S, Xing A. Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy.
Saudi Med. J. 30: 1406-1410 (2009).
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Cui Y, Konig J, Keppler D. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2.
Mol. Pharmacol. 60: 934-943 (2001).
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Cui Y, Konig J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.
J. Biol. Chem. 276: 9626-9630 (2001).
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Cui Y, Konig J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.
Lab. Invest. 83: 527-538 (2003).
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Dawson PA, Lan T, Rao A. Bile acid transporters.
J. Lipid Res. 50: 2340-2357 (2009).
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Deeley RG, Cole SP. Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).
FEBS Lett. 580: 1103-1111 (2006).
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Deguchi T, Isozaki K, Yousuke K, Terasaki T, Otagiri M. Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.
J. Neurochem. 96: 1051-1059 (2006).
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Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.
Hepatology 39: 1382-1389 (2004).
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Denson LA, Auld KL, Schiek DS, McClure MH, Mangelsdorf DJ, Karpen SJ. Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.
J. Biol. Chem. 275: 8835-8843 (2000).
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Denson LA, Bohan A, Held MA, Boyer JL. Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis.
Gastroenterology 123: 599-607 (2002).
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Diaz GJ. Basolateral and canalicular transport of xenobiotics in the hepatocyte: a review.
Cytotechnology 34: 225-235 (2000).
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Diena T, Melani R, Caci E, Pedemonte N, Sondo E, Zegarra-Moran O, Galietta LJ. Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.
Eur. J. Pharmacol. 560: 127-131 (2007).
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Dietrich CG, Ottenhoff R, de Waart DR, Oude Elferink RP. Role of MRP2 and GSH in intrahepatic cycling of toxins.
Toxicology 167: 73-81 (2001).
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Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
J. Biol. Chem. 281: 26540-26551 (2006).
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Donner MG, Schumacher S, Warskulat U, Heinemann J, Haussinger D. Obstructive cholestasis induces TNF-alpha- and IL-1beta-mediated periportal down-regulation of Bsep and zonal regulation of Ntcp, Oatp1a4 and Oatp1b2.
Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1134-G1146 (2007).
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Dransfeld O, Gehrmann T, Kohrer K, Kircheis G, Holneicher C, Haussinger D, Wettstein M. Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver.
Liver Int. 25: 1243-1258 (2005).
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Dumont M, Jacquemin E, D'Hont C, Descout C, Cresteil D, Haouzi D, Desrochers M, Stieger B, Hadchouel M, Erlinger S. Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation.
J. Hepatol. 27: 1051-1056 (1997).
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Eloranta JJ, Kullak-Ublick GA. Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism.
Arch. Biochem. Biophys. 433: 397-412 (2005).
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Elwi AN, Damaraju VL, Baldwin SA, Young JD, Sawyer MB, Cass CE. Renal nucleoside transporters: physiological and clinical implications.
Biochem. Cell. Biol. 84: 844-858 (2006).
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Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease.
Clin. Exp. Nephrol. 9: 195-205 (2005).
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Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK. The molecular pharmacology of organic anion transporters: from DNA to FDA?
Mol. Pharmacol. 65: 479-487 (2004).
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Eraly SA, Hamilton BA, Nigam SK. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes.
Biochem. Biophys. Res. Commun. 300: 333-342 (2003).
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Eraly SA, Monte JC, Nigam SK. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters.
Physiol. Genomics 18: 12-24 (2004).
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Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
Am. J. Physiol. Renal Physiol. 290: F905-F912 (2006).
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Erlinger S. Mechanisms of hepatic transport and bile secretion.
Acta Gastroenterol. Belg. 59: 159-162 (1996).
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Erlinger S. Review article: new insights into the mechanisms of hepatic transport and bile secretion.
J. Gastroenterol. Hepatol. 11: 575-579 (1996).
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Faber KN, Muller M, Jansen PL. Drug transport proteins in the liver.
Adv. Drug Deliv. Rev. 55: 107-124 (2003).
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Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B. Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2.
Hepatology 32: 82-86 (2000).
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Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K, Jaeschke H, Denk H, Trauner M. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
Am. J. Pathol. 168: 410-422 (2006).
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Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver.
Gastroenterology 121: 170-183 (2001).
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Frank C, Makkonen H, Dunlop TW, Matilainen M, Vaisanen S, Carlberg C. Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis.
J. Mol. Biol. 346: 505-519 (2005).
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Friesema EC, Jansen J, Milici C, Visser TJ. Thyroid hormone transporters.
Vitam. Horm. 70: 137-167 (2005).
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Friesema ECh, Jansen J, Heuer H, Trajkovic M, Bauer K, Visser TJ. Mechanisms of disease: psychomotor retardation and high T(3) levels caused by mutations in monocarboxylate transporter 8.
Nat. Clin. Pract. Endocrinol. Metab. 2: 512-523 (2006).
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Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T. Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.
Biol. Pharm. Bull. 30: 556-561 (2007).
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Furihata T, Satoh T, Yamamoto N, Kobayashi K, Chiba K. Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers.
Pharm. Res. 24: 2327-2332 (2007).
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Gao B, St Pierre MV, Stieger B, Meier PJ. Differential expression of bile salt and organic anion transporters in developing rat liver.
J. Hepatol. 41: 201-208 (2004).
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Gartung C, Matern S. Molecular regulation of sinusoidal liver bile acid transporters during cholestasis.
Yale J. Biol. Med. 70: 355-363 (1997).
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Gatmaitan ZC, Nies AT, Arias IM. Regulation and translocation of ATP-dependent apical membrane proteins in rat liver.
Am. J. Physiol. 272: G1041-G1049 (1997).
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Geier A, Dietrich CG, Gerloff T, Haendly J, Kullak-Ublick GA, Stieger B, Meier PJ, Matern S, Gartung C. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.
Biochim. Biophys. Acta 1609: 87-94 (2003).
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Geier A, Dietrich CG, Grote T, Beuers U, Prufer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.
J. Hepatol. 43: 1021-1030 (2005).
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Geier A, Dietrich CG, Lammert F, Orth T, Mayet WJ, Matern S, Gartung C. Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.
J. Hepatol. 36: 718-724 (2002).
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Geier A, Dietrich CG, Trauner M, Gartung C. Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Liver Int. 27: 1056-1065 (2007).
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Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, Suchy FJ, Matern S, Gartung C. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver.
Am. J. Physiol. Gastrointest. Liver Physiol. 289: G831-G841 (2005).
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Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Hepatology 38: 345-354 (2003).
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Geier A, Gartung C, Matern S. Regulation of hepatobiliary transporters in cholestatic liver disease.
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David and Judy Rhodes
Last Update: 1/16/2010
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