• Aarsetoey H, Ponitz V, Grundt H, Staines H, Harris WS, Nilsen DW. (n-3) Fatty acid content of red blood cells does not predict risk of future cardiovascular events following an acute coronary syndrome. J. Nutr. 139: 507-513 (2009). *

• Abdelmalek MF, Sanderson SO, Angulo P, Soldevila-Pico C, Liu C, Peter J, Keach J, Cave M, Chen T, McClain CJ, Lindor KD. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology 50: 1818-1826 (2009). *

• Acharya U, Gau JT, Horvath W, Ventura P, Hsueh CT, Carlsen W. Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature. J. Hematol. Oncol. 1: 26 (2008). *

• Adinolfi LE, Ingrosso D, Cesaro G, Cimmino A, D'Anto M, Capasso R, Zappia V, Ruggiero G. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 41: 995-1003 (2005). *

• Aflaki E, Mehryar M, Nazarinia MA, Habibagahi Z, Rajaee A, Ranjbar-Omrani G. The relation between serum homocysteine level and eye involvement in Behcet's disease. Arch. Iran. Med. 11: 625-628 (2008). *

• Agrawal N, Banerjee R. Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. PLoS ONE 3: e4032 (2008). *

• Aithal GP. Dangerous liaisons: drug, host and the environment. J. Hepatol. 46: 995-998 (2007). *

• Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I. Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum. Mol. Genet. 17: 1994-2005 (2008). *

• Akar N, Koc Y. Single nucleotide polymorphisms that affect homocysteine levels in Turkish population. Clin. Appl. Thromb. Hemost. 15: 701-704 (2009).

• Akoglu B, Kindl P, Weber N, Trojan J, Caspary WF, Faust D. Polymorphisms in the methylenetetrahydrofolate reductase gene are determinant for vascular complications after liver transplantation. Eur. J. Clin. Nutr. 62: 430-435 (2008). *

• Akoglu B, Schrott M, Bolouri H, Jaffari A, Kutschera E, Caspary WF, Faust D. The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study. Eur. J. Clin. Nutr. 62: 796-801 (2008). *

• Aksungar FB, Topkaya AE, Yildiz Z, Sahin S, Turk U. Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J. Clin. Neurosci. 15: 393-397 (2008).

• Al M, Ng L, Tyrrell P, Bargman J, Bradley T, Silverman E. Adipokines as novel biomarkers in paediatric systemic lupus erythematosus. Rheumatology (Oxford) 48: 497-501 (2009).

• Al-Ali AK, Al-Muhana FA, Larbi EB, Abdulmohsen MF, Al-Sultan AI, Al-Maden MS, Al-Ateeq SA. Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia. Saudi Med. J. 26: 1886-1888 (2005).

• Al-Allawi NA, Avo AS, Jubrael JM. Methylenetetrahydrofolate reductase C677T polymorphism in Iraqi patients with ischemic stroke. Neurol. India 57: 631-635 (2009).

• Al-Awadi F, Yang M, Tan Y, Han Q, Li S, Hoffman RM. Human tumor growth in nude mice is associated with decreased plasma cysteine and homocysteine. Anticancer Res. 28: 2541-2544 (2008).

• Al-Tahan J, Sola R, Ruiz JR, Breidenassel C, García-Fuentes M, Moreno LA, Castillo M, Pietrzik K, Gonzalez-Gross M. Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents. Ann. Nutr. Metab. 52: 315-321 (2008).

• Alam MA, Husain SA, Narang R, Chauhan SS, Kabra M, Vasisht S. Association of polymorphism in the thermolabile 5,10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease. Mol. Cell. Biochem. 310: 111-117 (2008).

• Albert MA. Inflammatory biomarkers, race/ethnicity and cardiovascular disease. Nutr. Rev. 65: S234-S238 (2007).

• Albert MA, Pare G, Morris A, Rose L, Buring J, Ridker PM, Zee RY. Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups. Am. Heart J. 157: 777-783.e1 (2009).

• Alessio AC, Annichino-Bizzacchi JM, Bydlowski SP, Eberlin MN, Vellasco AP, Hoehr NF. Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children. Am. J. Med. Genet. A. 128A: 256-260 (2004).

• Alessio AC, Siqueira LH, Bydlowski SP, Hoehr NF, Annichino-Bizzacchi JM. Polymorphisms in the CBS gene and homocysteine, folate and vitamin B12 levels: association with polymorphisms in the MTHFR and MTRR genes in Brazilian children. Am. J. Med. Genet. A. 146A: 2598-2602 (2008).

• Alexandru N, Jardín I, Popov D, Simionescu M, García-Estan J, Salido GM, Rosado JA. Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. J. Cell. Mol. Med. 12: 2015-2026 (2008).

• Alley RA, Chen EL, Beyer TD, Prinz RA. Does homocysteine contribute to bone disease in hyperparathyroidism? Am. J. Surg. 195: 374-377 (2008). *

• Almeida OP, McCaul K, Hankey GJ, Norman P, Jamrozik K, Flicker L. Homocysteine and depression in later life. Arch. Gen. Psychiatry 65: 1286-1294 (2008).

• Alonso-Aperte E, Gonzalez MP, Poo-Prieto R, Varela-Moreiras G. Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans. Eur. J. Clin. Nutr. 62: 295-298 (2008). *

• Angeline T, Jeyaraj N, Tsongalis GJ. MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients. Exp. Mol. Pathol. 82: 227-233 (2007). *

• Annerbo S, Kivipelto M, Lokk J. A prospective study on the development of Alzheimer's disease with regard to thyroid-stimulating hormone and homocysteine. Dement. Geriatr. Cogn. Disord. 28: 275-280 (2009).

• Antoniades C, Antonopoulos AS, Tousoulis D, Marinou K, Stefanadis C. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur. Heart J. 30: 6-15 (2009).

• Antoniades C, Shirodaria C, Leeson P, Baarholm OA, Van-Assche T, Cunnington C, Pillai R, Ratnatunga C, Tousoulis D, Stefanadis C, Refsum H, Channon KM. MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation 119: 2507-2515 (2009). *

• Ara AI, Xia M, Ramani K, Mato JM, Lu SC. S-Adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology 47: 1655-1666 (2008). *

• Ashktorab H, Begum R, Akhgar A, Smoot DT, Elbedawi M, Daremipouran M, Zhao A, Momen B, Giardiello FM. Folate status and risk of colorectal polyps in African Americans. Dig. Dis. Sci. 52: 1462-1470 (2007). *

• Assies J, Lok A, Bockting CL, Weverling GJ, Lieverse R, Visser I, Abeling NG, Duran M, Schene AH. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot. Essent. Fatty Acids 70: 349-356 (2004). *

• Ates O, Keles M, Uyanik A, Bilen H, Cetinkaya R, Turkeli M. Central retinal vein thrombosis and hyperhomocysteinemia in a young patient with renal transplantation. Transplant. Proc. 40: 3755-3758 (2008). *

• Atkinson W, Elmslie J, Lever M, Chambers ST, George PM. Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. Am. J. Clin. Nutr. 87: 577-585 (2008). *

• Atkinson W, Slow S, Elmslie J, Lever M, Chambers ST, George PM. Dietary and supplementary betaine: effects on betaine and homocysteine concentrations in males. Nutr. Metab. Cardiovasc. Dis. 19: 767-773 (2009).

• Audia S, Duchene C, Samson M, Muller G, Bielefeld P, Ricolfi F, Giroud M, Besancenot JF. Stroke in young adults with celiac disease. Rev. Med. Interne. 29: 228-231 (2008).

• Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J. Inherit. Metab. Dis. 26: 745-759 (2003). *

• Avila MA, Berasain C, Torres L, Martin-Duce A, Corrales FJ, Yang H, Prieto J, Lu SC, Caballeria J, Rodes J, Mato JM. Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J. Hepatol. 33: 907-914 (2000). *

• Aydin E, Demir HD, Ozyurt H, Etikan I. Association of plasma homocysteine and macular edema in type 2 diabetes mellitus. Eur. J. Ophthalmol. 18: 226-232 (2008).

• Baggott JE, Tamura T. Iron-dependent formation of homocysteine from methionine and other thioethers. Eur. J. Clin. Nutr. 61: 1359-1363 (2007). *

• Bai YP, Liu YH, Chen J, Song T, You Y, Tang ZY, Li YJ, Zhang GG. Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK(1/2)/p38MAPK activation. Biochem. Biophys. Res. Commun. 360: 20-26 (2007). *

• Balci DD, Yonden Z, Yenin JZ, Okumus N. Serum homocysteine, folic acid and vitamin B12 levels in vitiligo. Eur. J. Dermatol. 19: 382-383 (2009).

• Banait VS, Sandeep MS, Shetty S, Bapat MR, Rathi PM, Ghosh K, Mohanty D, Abraham P. Hypercoagulable state in idiopathic ulcerative colitis: role of hyperhomocysteinemia and hyperfibrinogenemia. Indian J. Gastroenterol. 27: 94-98 (2008). *

• Banerjee R, Zou CG. Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Arch. Biochem. Biophys. 433: 144-156 (2005). *

• Barak AJ, Beckenhauer HC, Mailliard ME, Kharbanda KK, Tuma DJ. Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats. J. Nutr. 133: 2845-2848 (2003). *

• Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 13: 395-398 (1996). *

• Barak AJ, Beckenhauer HC, Tuma DJ. Methionine synthase: a possible prime site of the ethanolic lesion in liver. Alcohol 26: 65-67 (2002). *

• Barbosa PR, Stabler SP, Machado AL, Braga RC, Hirata RD, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur. J. Clin. Nutr. 62: 1010-1021 (2008). *

• Barbosa PR, Stabler SP, Trentin R, Carvalho FR, Luchessi AD, Hirata RD, Hirata MH, Allen RH, Guerra-Shinohara EM. Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women. Clin. Chim. Acta 388: 139-147 (2008). *

• Baric I. Inherited disorders in the conversion of methionine to homocysteine. J. Inherit. Metab. Dis. 32: 459-471 (2009). *

• Baric I, Fumic K, Glenn B, Cuk M, Schulze A, Finkelstein JD, James SJ, Mejaski-Bosnjak V, Pazanin L, Pogribny IP, Rados M, Sarnavka V, Scukanec-Spoljar M, Allen RH, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd SH. S-Adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc. Natl. Acad. Sci. U.S.A. 101: 4234-4239 (2004). *

• Barve S, Joshi-Barve S, Song Z, Hill D, Hote P, Deaciuc I, McClain C. Interactions of cytokines, S-adenosylmethionine, and S-adenosylhomocysteine in alcohol-induced liver disease and immune suppression. J. Gastroenterol. Hepatol. 21 Suppl. 3: S38-S42 (2006). *

• Baskan BM, Sivas F, Aktekin LA, Dogan YP, Ozoran K, Bodur H. Serum homocysteine level in patients with ankylosing spondylitis. Rheumatol. Int. 29: 1435-1439 (2009). *

• Battistelli S, Vittoria A, Stefanoni M, Bing C, Roviello F. Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. World J. Gastroenterol. 12: 6128-6132 (2006). *

• Bauchart-Thevret C, Stoll B, Burrin DG. Intestinal metabolism of sulfur amino acids. Nutr. Res. Rev. 22: 175-187 (2009).

• Bauchart-Thevret C, Stoll B, Chacko SK, Burrin DG. Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am. J. Physiol. Endocrinol. Metab. 296: E1239-E1250 (2009). *

• Beagle B, Yang TL, Hung J, Cogger EA, Moriarty DJ, Caudill MA. The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. J. Nutr. 135: 2780-2785 (2005). *

• Beavers KM, Beavers DP, Bowden RG, Wilson RL, Gentile M. Omega-3 fatty acid supplementation and total homocysteine levels in end-stage renal disease patients. Nephrology (Carlton) 13: 284-288 (2008). *

• Becker A, Smulders YM, van Guldener C, Stehouwer CD. Epidemiology of homocysteine as a risk factor in diabetes. Metab. Syndr. Relat. Disord. 1: 105-120 (2003).

• Beetstra S, Suthers G, Dhillon V, Salisbury C, Turner J, Altree M, McKinnon R, Fenech M. Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. Cancer Epidemiol. Biomarkers Prev. 17: 2565-2571 (2008). *

• Belcastro V, Gaetano G, Italiano D, Oteri G, Caccamo D, Pisani LR, Striano P, Striano S, Ientile R, Pisani F. Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients. Epilepsia 48: 1990-1994 (2007).

• Belkahla R, Omezzine A, Kchok K, Rebhi L, Ben Hadj Mbarek I, Rejeb J, Ben Rejeb N, Slimane N, Nabli N, Ben Abdelaziz A, Boughzala E, Bouslama A. Effect of polymorphisms on key enzymes in homocysteine metabolism, on plasma homocysteine level and on coronary artery-disease risk in a Tunisian population. Ann. Cardiol. Angeiol. (Paris) 57: 219-224 (2008).

• Ben-Ari Z, Tur-Kaspa R, Schafer Z, Baruch Y, Sulkes J, Atzmon O, Greenberg A, Levi N, Fainaru M. Basal and post-methionine serum homocysteine and lipoprotein abnormalities in patients with chronic liver disease. J. Investig. Med. 49: 325-329 (2001).

• Benito P, Caballero J, Moreno J, Gutierrez-Alcantara C, Munoz C, Rojo G, Garcia S, Soriguer FC. Effects of milk enriched with omega-3 fatty acid, oleic acid and folic acid in patients with metabolic syndrome. Clin. Nutr. 25: 581-587 (2006).

• Benyamina A, Saffroy R, Blecha L, Pham P, Karila L, Debuire B, Lemoine A, Reynaud M. Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology. Addict. Biol. 14: 503-505 (2009).

• Benzinger P, Alscher DM. Untreated homocystinuria in adulthood. Dtsch. Med. Wochenschr. 130: 2439-2443 (2005).

• Berkun Y, Atta IA, Rubinow A, Orbach H, Levartovsky D, Aamar S, Arbel O, Dresner-Pollak R, Friedman G, Ben-Yehuda A. 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis. J. Rheumatol. 34: 1664-1669 (2007).

• Bernstein CN. Osteoporosis and other complications of inflammatory bowel disease. Curr. Opin. Gastroenterol. 18: 428-434 (2002).

• Bernstein CN. Is hyperhomocysteinemia associated with osteoporosis in patients with Crohn's disease? Nat. Clin. Pract. Gastroenterol. Hepatol. 4: 550-551 (2007). *

• Berstad P, Konstantinova SV, Refsum H, Nurk E, Vollset SE, Tell GS, Ueland PM, Drevon CA, Ursin G. Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 85: 1598-1605 (2007). *

• Bezemer ID, Doggen CJ, Vos HL, Rosendaal FR. No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study. Arch. Intern. Med. 167: 497-501 (2007). *

• Biagini MR, Tozzi A, Bongini E, Capanni M, Galli A, Milani S, Surrenti C. Association of plasma homocysteine with bone mineral density in postmenopausal women with osteoporosis or osteopenia affected by primary biliary cirrhosis. J. Clin. Gastroenterol. 41: 635 (2007).

• Biagini MR, Tozzi A, Marcucci R, Paniccia R, Fedi S, Milani S, Galli A, Ceni E, Capanni M, Manta R, Abbate R, Surrenti C. Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis. World J. Gastroenterol. 12: 1607-1612 (2006). *

• Birch CS, Brasch NE, McCaddon A, Williams JH. A novel role for vitamin B12: cobalamins are intracellular antioxidants in vitro. Free Radic. Biol. Med. 47: 184-188 (2009).

• Biselli JM, Goloni-Bertollo EM, Haddad R, Eberlin MN, Pavarino-Bertelli EC. The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome. Braz. J. Med. Biol. Res. 41: 34-40 (2008). *

• Biselli PM, Guerzoni AR, de Godoy MF, Eberlin MN, Haddad R, Carvalho VM, Vannucchi H, Pavarino-Bertelli EC, Goloni-Bertollo EM. Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease. J. Thromb. Thrombolysis 29: 32-40 (2010).

• Biselli PM, Sanches de Alvarenga MP, Abbud-Filho M, Ferreira-Baptista MA, Galbiatti AL, Goto MT, Cardoso MA, Eberlin MN, Haddad R, Goloni-Bertollo EM, Pavarino-Bertelli EC. Effect of folate, vitamin B(6), and vitamin B(12) intake and MTHFR C677T polymorphism on homocysteine concentrations of renal transplant recipients. Transplant. Proc. 39: 3163-3165 (2007). *

• Bjerregaard LT, Nederby NJ, Fredholm L, Brandslund I, Munkholm P, Hey H. Hyperhomocysteinaemia, coagulation pathway activation and thrombophilia in patients with inflammatory bowel disease. Scand. J. Gastroenterol. 37: 62-67 (2002). *

• Bjorke-Monsen AL, Torsvik I, Saetran H, Markestad T, Ueland PM. Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation. Pediatrics 122: 83-91 (2008). *

• Bleie O, Semb AG, Grundt H, Nordrehaug JE, Vollset SE, Ueland PM, Nilsen DW, Bakken AM, Refsum H, Nygard OK. Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. J. Intern. Med. 262: 244-253 (2007). *

• Block G, Jensen CD, Norkus EP, Dalvi TB, Wong LG, McManus JF, Hudes ML. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study. Nutr. J. 6: 30 (2007). *

• Bogdanski P, Pupek-Musialik D, Dytfeld J, Lacinski M, Jablecka A, Jakubowski H. Plasma homocysteine is a determinant of tissue necrosis factor-alpha in hypertensive patients. Biomed. Pharmacother. 62: 360-365 (2008).

• Boger CA, Stubanus M, Haak T, Gotz AK, Christ J, Hoffmann U, Riegger GA, Kramer BK. Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy. Nephrol. Dial. Transplant. 22: 154-162 (2007).

• Boison D, Scheurer L, Zumsteg V, Rulicke T, Litynski P, Fowler B, Brandner S, Mohler H. Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc. Natl. Acad. Sci. U.S.A. 99: 6985-6990 (2002). *

• Boldyrev AA. Molecular mechanisms of homocysteine toxicity. Biochemistry (Mosc.) 74: 589-98 (2009).

• Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K; NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N. Engl. J. Med. 354: 1578-1588 (2006). *

• Bosco P, Gueant-Rodriguez RM, Anello G, Barone C, Namour F, Caraci F, Romano A, Romano C, Gueant JL. Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome. Am. J. Med. Genet. A. 121A: 219-224 (2003).

• Bosco P, Gueant-Rodriguez RM, Anello G, Spada R, Romano A, Fajardo A, Caraci F, Ferri R, Gueant JL. Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily. Thromb. Haemost. 96: 154-159 (2006).

• Bosy-Westphal A, Petersen S, Hinrichsen H, Czech N, J Muller M. Increased plasma homocysteine in liver cirrhosis. Hepatol. Res. 20: 28-38 (2001).

• Bottiger AK, Hurtig-Wennlof A, Sjostrom M, Yngve A, Nilsson TK. Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents. Int. J. Mol. Med. 19: 659-665 (2007). *

• Botto N, Andreassi MG, Manfredi S, Masetti S, Cocci F, Colombo MG, Storti S, Rizza A, Biagini A. Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur. J. Hum. Genet. 11: 671-678 (2003). *

• Bougteba A, Basir A, Kissani N. Recurrent ischemic stroke revealing Biermer's disease. Rev. Neurol. (Paris) 165: 1099-1102 (2009).

• Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ. Health Perspect. 114: 1547-1552 (2006). *

• Bridges CC, Zalups RK. System B0,+ and the transport of thiol-S-conjugates of methylmercury. J. Pharmacol. Exp. Ther. 319: 948-956 (2006). *

• Brockton NT. Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate? Cancer Causes Control 17: 1005-1016 (2006). *

• Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J. Nutr. 136: 1636S-1640S (2006). *

• Brouns R, Ursem N, Lindemans J, Hop W, Pluijm S, Steegers E, Steegers-Theunissen R. Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects. Prenat. Diagn. 28: 485-493 (2008).

• Brown KS, Nackos E, Morthala S, Jensen LE, Whitehead AS, VON Feldt JM. Independent role of conventional cardiovascular risk factors as predictors of C-reactive protein concentrations in rheumatoid arthritis. J. Rheumatol. 34: 740-746 (2007).

• Brown WV. Expert commentary: the safety of fibrates in lipid-lowering therapy. Am. J. Cardiol. 99: S19-S21 (2007). *

• Bruce WR, Cirocco M, Giacca A, Kim YI, Marcon N, Minkin S. A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation. Br. J. Cancer 93: 639-646 (2005).

• Buchel O, Roskams T, Van Damme B, Nevens F, Pirenne J, Fevery J. Nodular regenerative hyperplasia, portal vein thrombosis, and avascular hip necrosis due to hyperhomocysteinaemia. Gut 54: 1021-1023 (2005). *

• Burren KA, Savery D, Massa V, Kok RM, Scott JM, Blom HJ, Copp AJ, Greene ND. Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum. Mol. Genet. 17: 3675-3685 (2008).

• Burrin DG, Stoll B. Emerging aspects of gut sulfur amino acid metabolism. Curr. Opin. Clin. Nutr. Metab. Care 10: 63-68 (2007).

• Cai B, Pan Z, Gong D, Lu Y, Liu J, Shan L, Xu C, Yang B. Homocysteine modulates sodium channel currents in human atrial myocytes. Toxicology 256: 201-206 (2009). *

• Cakmak SK, Gul U, Kilic C, Gonul M, Soylu S, Kilic A. Homocysteine, vitamin B(12) and folic acid levels in psoriasis patients. J. Eur. Acad. Dermatol. Venereol. 23: 300-303 (2009). *

• Calvisi DF, Simile MM, Ladu S, Pellegrino R, De Murtas V, Pinna F, Tomasi ML, Frau M, Virdis P, De Miglio MR, Muroni MR, Pascale RM, Feo F. Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis. Int. J. Cancer 121: 2410-2420 (2007). *

• Canataroglu A, Tanriverdi K, Inal T, Seydaoglu G, Arslan D, Ozbek S, Baslamisli F. Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behcet's disease. Rheumatol. Int. 23: 236-240 (2003). *

• Cara Terribas CJ, Gonzalez Guijarro L. Hypomethylation and multiple sclerosis, the susceptibility factor? Neurologia 17: 132-135 (2002).

• Carluccio MA, Ancora MA, Massaro M, Carluccio M, Scoditti E, Distante A, Storelli C, De Caterina R. Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation - protective role of Mediterranean diet polyphenolic antioxidants. Am. J. Physiol. Heart Circ. Physiol. 293: H2344-H2354 (2007). *

• Carmichael SL, Shaw GM, Iovannisci DM, Yang W, Finnell RH, Cheng S, Lammer EJ. Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. Am. J. Med. Genet. A. 140: 2433-2440 (2006).

• Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem. Pharmacol. 69: 1081-1093 (2005). *

• Caro AA, Cederbaum AI. Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations. Free Radic. Biol. Med. 36: 1303-1316 (2004).

• Carrero JJ, Fonolla J, Marti JL, Jimenez J, Boza JJ, Lopez-Huertas E. Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. J. Nutr. 137: 384-390 (2007). *

• Casais P, Alberto MF, Salviu MJ, Meschengieser SS, Aixala M, Lazzari MA. Pilot study of homocysteine and cysteine in patients with thrombosis in different vascular sites. Epidemiology and response to folate. Thromb. Res. 123: 592-596 (2009). *

• Casais P, Meschengieser SS, Gennari LC, Alberto MF, Sanchez-Luceros A, Blanco AN, Lazzari MA. Antiphospholipid antibodies and hyperhomocysteinaemia in patients with vascular occlusive disease. Thromb. Haemost. 96: 19-23 (2006).

• Cases Amenos A, Goicoechea Diezhandino M, de Alvaro Moreno F. Arterial hypertension and dyslipidemia in patients with chronic kidney disease (CKD). Anti-platelet aggregation. Goal oriented treatment. Nefrologia 28 Suppl. 3: 39-48 (2008).

• Cashman KD. Homocysteine and osteoporotic fracture risk: a potential role for B vitamins. Nutr. Rev. 63: 29-36 (2005).

• Castro C, Millian NS, Garrow TA. Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch. Biochem. Biophys. 472: 26-33 (2008). *

• Cattaneo M, Vecchi M, Zighetti ML, Saibeni S, Martinelli I, Omodei P, Mannucci PM, de Franchis R. High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications? Thromb. Haemost. 80: 542-545 (1998). *

• Caudill MA, Dellschaft N, Solis C, Hinkis S, Ivanov AA, Nash-Barboza S, Randall KE, Jackson B, Solomita GN, Vermeylen F. Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genoref-type predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genoref-type. J. Nutr. 139: 727-733 (2009). *

• Chan E, Fonseca VA. Management of hyperhomocysteinemia. Metab. Syndr. Relat. Disord. 1: 159-170 (2003).

• Chang L, Zhang Z, Li W, Dai J, Guan Y, Wang X. Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway. Biochem. Biophys. Res. Commun. 357: 772-778 (2007). *

• Chapkin RS, Kamen BA, Callaway ES, Davidson LA, George NI, Wang N, Lupton JR, Finnell RH. Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. J. Nutr. Biochem. 20: 649-655 (2009). *

• Chen J, Kyte C, Valcin M, Chan W, Wetmur JG, Selhub J, Hunter DJ, Ma J. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int. J. Cancer 110: 617-620 (2004). *

• Chen J, Ma J, Stampfer MJ, Palomeque C, Selhub J, Hunter DJ. Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics 12: 339-342 (2002).

• Chen M, Peyrin-Biroulet L, Xia B, Rodriguez-Gueant RM, Bronowicki JP, Bigard MA, Gueant JL. Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China. BMC Med. Genet. 9: 78 (2008). *

• Chen M, Wang Y, Zhao Y, Wang L, Gong J, Wu L, Gao X, Yang Z, Qian L. Dynamic proteomic and metabonomic analysis reveal dysfunction and subclinical injury in rat liver during restraint stress. Biochim. Biophys. Acta 1794: 1751-1765 (2009). *

• Chen YM, Chen LY, Wong FH, Lee CM, Chang TJ, Yang-Feng TL. Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. Genomics 66: 43-47 (2000). *

• Cheng CH, Huang YC, Chen FP, Chou MC, Tsai TP. B-vitamins, homocysteine and gene polymorphism in adults with fasting or post-methionine loading hyperhomocysteinemia. Eur. J. Nutr. 47: 491-498 (2008). *

• Chern CL, Huang RF, Chen YH, Cheng JT, Liu TZ. Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells. Biomed. Pharmacother. 55: 434-442 (2001).

• Chiang EP, Wang YC, Chen WW, Tang FY. Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis and global DNA methylation. J. Clin. Endocrinol. Metab. 94: 1017-1025 (2009).

• Chiarello PG, Penaforte FR, Japur CC, Souza CD, Vannucchi H, Troncon LE. Increased folate Intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases. Dig. Dis. Sci. 54: 627-633 (2009). *

• Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R. H2S biogenesis by cystathionine gamma-lyase leads to the novel sulfur metabolites, lanthionine and homolanthionine, and is responsive to the grade of hyperhomocysteinemia. J. Biol. Chem. 284: 11601-11612 (2009). *

• Cho SE, Sook Hong K, Shin GJ, Chung WS. The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea. Clin. Chem. Lab. Med. 44: 1070-1075 (2006). *

• Chowers Y, Sela BA, Holland R, Fidder H, Simoni FB, Bar-Meir S. Increased levels of homocysteine in patients with Crohn's disease are related to folate levels. Am. J. Gastroenterol. 95: 3498-3502 (2000). *

• Chu NF. Plasma hyperhomocysteinemia, MTHFR polymorphism and thromboembolic disease: an example of gene-nutrition interactions in chronic disease. J. Chin. Med. Assoc. 68: 557-559 (2005).

• Chuang CZ, Boyles A, Legardeur B, Su J, Japa S, Lopez SA. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects. Am. J. Med. Sci. 331: 65-71 (2006).

• Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Stein CM. High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. Ann. Rheum. Dis. 66: 208-214 (2007). *

• Chung SL, Chiou KR, Charng MJ. 677TT polymorphism of methylenetetrahydrofolate reductase in combination with low serum vitamin B(12) is associated with coronary in-stent restenosis. Catheter Cardiovasc. Interv. 67: 349-355 (2006).

• Ciaccio M, Bivona G, Bellia C. Therapeutical approach to plasma homocysteine and cardiovascular risk reduction. Ther. Clin. Risk Manag. 4: 219-224 (2008). *

• Cicero AF, Derosa G, Miconi A, Laghi L, Nascetti S, Gaddi A. Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates. Biomed. Pharmacother. 59: 312-317 (2005).

• Clement CI, Goldberg I, Healey PR, Graham SL. Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma. J. Glaucoma 18: 73-78 (2009).

• Coelho D, Suormala T, Stucki M, Lerner-Ellis JP, Rosenblatt DS, Newbold RF, Baumgartner MR, Fowler B. Gene identification for the cblD defect of vitamin B12 metabolism. N. Engl. J. Med. 358: 1454-1464 (2008). *

• Coll P, Guttormsen AB, Berstad A. Gastrointestinal disease with elevated plasma homocysteine level. Tidsskr. Nor. Laegeforen. 119: 3577-3579 (1999).

• Compher CW, Kinosian BP, Evans-Stoner N, Huzinec J, Buzby GP. Hyperhomocysteinemia is associated with venous thrombosis in patients with short bowel syndrome. JPEN J. Parenter. Enteral Nutr. 25: 1-7 (2001).

• Compher CW, Kinosian BP, Stoner NE, Lentine DC, Buzby GP. Choline and vitamin B12 deficiencies are interrelated in folate-replete long-term total parenteral nutrition patients. JPEN J. Parenter. Enteral Nutr. 26: 57-62 (2002). *

• Connolly GM, Cunningham R, McNamee PT, Young IS, Maxwell AP. Elevated homocysteine is a predictor of all-cause mortality in a prospective cohort of renal transplant recipients. Nephron. Clin. Pract. 114: c5-c11 (2009).

• Cook RJ, Horne DW, Wagner C. Effect of dietary methyl group deficiency on one-carbon metabolism in rats. J. Nutr. 119: 612-617 (1989). *

• Coppede F, Colognato R, Bonelli A, Astrea G, Bargagna S, Siciliano G, Migliore L. Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children. Am. J. Med. Genet. A. 143: 2006-2015 (2007).

• Couper JJ, Peña AS. Folate, homocysteine, and candidate genes for vascular disease in children with type 1 diabetes. Pediatr. Diabetes 9: 345-347 (2008).

• Craig SA. Betaine in human nutrition. Am. J. Clin. Nutr. 80: 539-549 (2004). *

• Crowe FL, Skeaff CM, McMahon JA, Williams SM, Green TJ. Lowering plasma homocysteine concentrations of older men and women with folate, vitamin B-12, and vitamin B-6 does not affect the proportion of (n-3) long chain polyunsaturated fatty acids in plasma phosphatidylcholine. J. Nutr. 138: 551-555 (2008). *

• Cuskelly GJ, Stacpoole PW, Williamson J, Baumgartner TG, Gregory JF 3rd. Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics. Am. J. Physiol. Endocrinol. Metab. 281: E1182-E1190 (2001). *

• D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb. Haemost. 83: 563-570 (2000). *

• Dagli N, Poyrazoglu OK, Dagli AF, Sahbaz F, Karaca I, Kobat MA, Bahcecioglu IH. Is inflammatory bowel disease a risk factor for early atherosclerosis? Angiology Apr 26 [Epub ahead of print] (2009).

• Dalmeijer GW, Olthof MR, Verhoef P, Bots ML, van der Schouw YT. Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. Eur. J. Clin. Nutr. 62: 386-394 (2008). *

• Daly C, Fitzgerald AP, O'Callaghan P, Collins P, Cooney MT, Graham IM; on behalf of the COMAC Group. Homocysteine increases the risk associated with hyperlipidaemia. Eur. J. Cardiovasc. Prev. Rehabil. 16: 150-155 (2009).

• Danese S, Sgambato A, Papa A, Scaldaferri F, Pola R, Sans M, Lovecchio M, Gasbarrini G, Cittadini A, Gasbarrini A. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am. J. Gastroenterol. 100: 886-895 (2005). *

• Dary O. Nutritional interpretation of folic acid interventions. Nutr. Rev. 67: 235-244 (2009). *

• Das UN. Do polyunsaturated fatty acids behave like an endogenous "polypill"? Med. Hypotheses 70: 430-434 (2008).

• Das UN. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease - but how and why? Prostaglandins Leukot. Essent. Fatty Acids 78: 11-19 (2008). *

• Das UN. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis. 7: 37 (2008). *

• Davidson MH. A clinical puzzle: fibrates and homocysteine elevation: editorial to: "Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine" by M. Lever et al. Cardiovasc. Drugs Ther. Oct 21 [Epub ahead of print] (2009).

• Davidson MH, Armani A, McKenney JM, Jacobson TA. Safety considerations with fibrate therapy. Am. J. Cardiol. 99: S3-S18 (2007). *

• Davis SR, Quinlivan EP, Shelnutt KP, Ghandour H, Capdevila A, Coats BS, Wagner C, Shane B, Selhub J, Bailey LB, Shuster JJ, Stacpoole PW, Gregory JF 3rd. Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women. J. Nutr. 135: 1045-1050 (2005). *

• Davis SR, Quinlivan EP, Shelnutt KP, Maneval DR, Ghandour H, Capdevila A, Coats BS, Wagner C, Selhub J, Bailey LB, Shuster JJ, Stacpoole PW, Gregory JF 3rd. The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women. J. Nutr. 135: 1040-1044 (2005). *

• Davis SR, Stacpoole PW, Williamson J, Kick LS, Quinlivan EP, Coats BS, Shane B, Bailey LB, Gregory JF 3rd. Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am. J. Physiol. Endocrinol. Metab. 286: E272-E279 (2004). *

• de Lau LM, Koudstaal PJ, van Meurs JB, Uitterlinden AG, Hofman A, Breteler MM. Methylenetetrahydrofolate reductase C677T genotype and PD. Ann. Neurol. 57: 927-930 (2005).

• Dealberto MJ. Why are immigrants at increased risk for psychosis? Vitamin D insufficiency, epigenetic mechanisms, or both? Med. Hypotheses 68: 259-267 (2007).

• Delgado M, Perez-Miguelsanz J, Garrido F, Rodriguez-Tarduchy G, Perez-Sala D, Pajares MA. Early effects of copper accumulation on methionine metabolism. Cell. Mol. Life Sci. 65: 2080-2090 (2008). *

• DeLong CJ, Hicks AM, Cui Z. Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells. J. Biol. Chem. 277: 17217-17225 (2002). *

• Deshmukh A, Rodrigue KM, Kennedy KM, Land S, Jacobs BS, Raz N. Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biol. Psychol. 80: 240-245 (2009).

• Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C. Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am. J. Clin. Nutr. 87: 424-430 (2008). *

• Dever JT, Elfarra AA. L-Methionine toxicity in freshly-isolated mouse hepatocytes is gender-dependent and mediated in part by transamination. J. Pharmacol. Exp. Ther. 326: 809-817 (2008). *

• Dhamija RK, Gaba P, Arora S, Kaintura A, Kumar M, Bhattacharjee J. Homocysteine and lipoprotein (a) correlation in ischemic stroke patients. J. Neurol. Sci. 281: 64-68 (2009).

• Dhonukshe-Rutten RA, de Vries JH, de Bree A, van der Put N, van Staveren WA, de Groot LC. Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. Eur. J. Clin. Nutr. 63: 18-30 (2009). *

• Di Giuseppe D, Ulivelli M, Bartalini S, Battistini S, Cerase A, Passero S, Summa D, Frosali S, Priora R, Margaritis A, Di Simplicio P. Regulation of redox forms of plasma thiols by albumin in multiple sclerosis after fasting and methionine loading test. Amino Acids Oct 2 [Epub ahead of print] (2009). *

• Dickey W, Ward M, Whittle CR, Kelly MT, Pentieva K, Horigan G, Patton S, McNulty H. Homocysteine and related B-vitamin status in coeliac disease: effects of gluten exclusion and histological recovery. Scand. J. Gastroenterol. 43: 682-688 (2008). *

• Diekman MJ, van der Put NM, Blom HJ, Tijssen JG, Wiersinga WM. Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism. Clin. Endocrinol. (Oxf.) 54: 197-204 (2001). *

• Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 354: 219-220 (1999). *

• Dierkes J, Westphal S, Luley C. Fenofibrate-induced hyperhomocysteinaemia: clinical implications and management. Drug Saf. 26: 81-91 (2003).

• Dierkes J, Westphal S, Luley C. The effect of fibrates and other lipid-lowering drugs on plasma homocysteine levels. Expert Opin. Drug Saf. 3: 101-111 (2004).

• Distrutti E, Mencarelli A, Santucci L, Renga B, Orlandi S, Donini A, Shah V, Fiorucci S. The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats. Hepatology 47: 659-667 (2008). *

• Diwakar L, Rudresh Kumar KJ, Bachnalkar A, Ravindranath V, Christopher R, Nagaraja D. The influence of MTR A2756G polymorphism on plasma homocysteine in young south Indians. Clin. Chim. Acta 395: 172-174 (2008). *

• do Prado R, D' Almeida VM, Guerra-Shinohara E, Galdieri LC, Terreri MT, Hilario MO. Increased concentration of plasma homocysteine in children with systemic lupus erythematosus. Clin. Exp. Rheumatol. 24: 594-598 (2006).

• Doherty NC, Shen F, Halliday NM, Barrett DA, Hardie KR, Winzer K, Atherton JC. In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulphuration pathway. J. Bacteriol. Jan 8 [Epub ahead of print] (2010). *

• Donohue TM, Curry-McCoy TV, Nanji AA, Kharbanda KK, Osna NA, Radio SJ, Todero SL, White RL, Casey CA. Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Alcohol Clin. Exp. Res. 31: 1944-1952 (2007). *

• Dos Santos EF, Busanello EN, Miglioranza A, Zanatta A, Barchak AG, Vargas CR, Saute J, Rosa C, Carrion MJ, Camargo D, Dalbem A, da Costa JC, de Sousa Miguel SR, de Mello Rieder CR, Wajner M. Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson's disease. Metab. Brain Dis. 24: 257-269 (2009).

• Drzewoski J, Gasiorowska A, Malecka-Panas E, Bald E, Czupryniak L. Plasma total homocysteine in the active stage of ulcerative colitis. J. Gastroenterol. Hepatol. 21: 739-743 (2006). *

• Ducros V, Barro C, Yver J, Pernod G, Polack B, Carpentier P, Desruets MD, Bosson JL. Should plasma homocysteine be used as a biomarker of venous thromboembolism? A case-control study. Clin. Appl. Thromb. Hemost. 15: 517-522 (2009).

• Durga J, van Boxtel MP, Schouten EG, Bots ML, Kok FJ, Verhoef P. Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance. Neurobiol. Aging 27: 334-343 (2006).

• Duthie SJ, Grant G, Pirie LP, Watson AJ, Margison GP. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev. Res. (Phila. Pa) 3: 92-100 (2010).

• Duzgun N, Duman T, Morris Y, Tutkak H, Kose K, Ertugrul E, Aydintug OT. Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behcet's disease Clin. Rheumatol. 27: 1221-1225 (2008). *

• Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sci. 76: 2497-2512 (2005). *

• Edgar KS, Woodside JV, Skidmore P, Cardwell C, Farelll K, McKinley MC, Youngl IS, Whitehead AS, Gey F, Yarnell JW, Evans A. Thiol and cardiovascular risk factor status in a male northern Irish population. Int. J. Vitam. Nutr. Res. 78: 208-216 (2008).

• Eklof V, Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Palmqvist R. The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. Scand. J. Clin. Lab. Invest. 68: 393-401 (2008).

• Ekmekci H, Ekmekci OB, Erdine S, Sonmez H, Ataev Y, Ozturk Z, Butun II, Gurel C, Kucur M, Turfaner N, Ulutin T, Purisa S, Vural VA. Effects of serum homocysteine and adiponectin levels on platelet aggregation in untreated patients with essential hypertension. J. Thromb. Thrombolysis 28: 418-424 (2009).

• Elikowski W, Malek M, Lewandowska M, Kawczynski S, Dobrowolska-Zachwieja A, Psuja P. Massive pulmonary embolism in a patient with ulcerative colitis and hyperhomocysteinemia - a case report. Kardiol. Pol. 64: 405-409 (2006).

• Elisaf M. Effects of fibrates on serum metabolic parameters. Curr. Med. Res. Opin. 18: 269-276 (2002).

• Elmadfa I, Singer I. Vitamin B-12 and homocysteine status among vegetarians: a global perspective. Am. J. Clin. Nutr. 89: 1693S-1698S (2009). *

• Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, Tverdal A, Vollset SE, Refsum H. Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am. J. Clin. Nutr. 88: 738-746 (2008). *

• Elshorbagy AK, Valdivia-Garcia M, Refsum H, Smith AD, Mattocks DA, Perrone CE. Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition Jan 15 [Epub ahead of print] (2010). *

• Enrico V, Ivano B, Gregoriana Z, Silvia F, Claudia F, Riccardo R, Livio DC. Homocysteine and heart failure: an overview. Recent Patents Cardiovasc. Drug Discov. 4: 15-21 (2009).

• Er H, Evereklioglu C, Cumurcu T, Turkoz Y, Ozerol E, Sahin K, Doganay S. Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease. Br. J. Ophthalmol. 86: 653-657 (2002). *

• Eren M, Nur Saltik-Temizel I, Kocak N. Serum homocysteine concentrations in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 39: 215-216 (2004). *

• Erzin Y, Uzun H, Celik AF, Aydin S, Dirican A, Uzunismail H. Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications. J. Clin. Gastroenterol. 42: 481-486 (2008).

• Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology Oct 19 [Epub ahead of print] (2009).

• Eussen SJ, Vollset SE, Hustad S, Midttun O, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Ferrari P, Agudo A, Sala N, Capella G, Del Giudice G, Palli D, Boeing H, Weikert C, Bueno-de-Mesquita HB, Buchner FL, Carneiro F, Berrino F, Vineis P, et al. Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol. Biomarkers Prev. 19: 28-38 (2010). *

• Evereklioglu C. Current concepts in the etiology and treatment of Behcet disease. Surv. Ophthalmol. 50: 297-350 (2005).

• Fabris C, Toniutto P, Falleti E, Fontanini E, Cussigh A, Bitetto D, Fornasiere E, Fumolo E, Avellini C, Minisini R, Pirisi M. MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption. Alcohol Clin. Exp. Res. 33: 102-107 (2009). *

• Famularo G, Minisola G, Nicotra GC, Simone CD. Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation. World J. Gastroenterol. 11: 7700-7701 (2005). *

• Favaloro EJ. Diagnostic issues in thrombophilia: a laboratory scientist's view. Semin. Thromb. Hemost. 31: 11-16 (2005).

• Fedosov SN. Metabolic signs of vitamin B(12) deficiency in humans: computational model and its implications for diagnostics. Metabolism Jan 4 [Epub ahead of print] (2010). *

• Feix A, Fritsche-Polanz R, Kletzmayr J, Vychytil A, Horl WH, Sunder-Plassmann G, Fodinger M. Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels. Am. J. Kidney Dis. 38: 956-964 (2001).

• Feki M, Houman H, Ghannouchi M, Smiti-Khanfir M, Hamzaoui K, Matri LE, Mebazaa A, Kaabachi N. Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behcet's disease. Clin. Chem. Lab. Med. 42: 1417-1423 (2004).

• Ferechide D, Radulescu D. Hyperhomocysteinemia in renal diseases. J. Med. Life 2: 53-59 (2009).

• Fermo I, Vigano' D'Angelo S, Paroni R, Mazzola G, Calori G, D'Angelo A. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann. Intern. Med. 123: 747-753 (1995). *

• Fernandez A, Colell A, Caballero F, Matias N, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol Clin. Exp. Res. 33: 1169-1180 (2009).

• Fernandez-Miranda C, Martinez Prieto M, Casis Herce B, Sanchez Gomez F, Gomez Gonzalez P, Martinez Lopez J, Saenz-Lopez Perez S, Gomez de la Camara A. Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C-->T and 1298A-->C mutations in patients with inflammatory bowel disease. Rev. Esp. Enferm. Dig. 97: 497-504 (2005). *

• Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH. S-Adenosyl homocysteine hydrolase (SAHH) is required for Myc-induced mRNA cap methylation, protein synthesis and cell proliferation. Mol. Cell Biol. 29: 6182-6191 (2009). *

• Ferroni P, Palmirotta R, Martini F, Riondino S, Savonarola A, Spila A, Ciatti F, Sini V, Mariotti S, Del Monte G, Roselli M, Guadagni F. Determinants of homocysteine levels in colorectal and breast cancer patients. Anticancer Res. 29: 4131-4138 (2009).

• Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin. Thromb. Hemost. 26: 219-225 (2000).

• Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J. Biol. Chem. 261: 1582-1587 (1986). *

• Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J. Biol. Chem. 259: 9508-9513 (1984). *

• Fonolla J, Lopez-Huertas E, Machado FJ, Molina D, Alvarez I, Marmol E, Navas M, Palacín E, Garcia-Valls MJ, Remon B, Boza JJ, Marti JL. Milk enriched with "healthy fatty acids" improves cardiovascular risk markers and nutritional status in human volunteers. Nutrition 25: 408-414 (2009). *

• Forestier M, Banninger R, Reichen J, Solioz M. Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis. Biochim. Biophys. Acta 1638: 29-34 (2003). *

• Forges T, Pellanda H, Diligent C, Monnier P, Gueant JL. Do folates have an impact on fertility? Gynecol. Obstet. Fertil. 36: 930-939 (2008).

• Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin. Vasc. Med. 5: 77-86 (2005).

• Fox JT, Stover PJ. Chapter 1. Folate-mediated one-carbon metabolism. Vitam. Horm. 79: 1-44 (2008).

• Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum. Mutat. 28: 856-865 (2007).

• Freitas AI, Mendonca I, Guerra G, Brion M, Reis RP, Carracedo A, Brehm A. Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal). Thromb. Res. 122: 648-656 (2008). *

• Frezza M, Terpin MM, Peri A. S-Adenosyl-L-methionine (SAMe) and its use in hepatology. Minerva Gastroenterol. Dietol. 38: 145-151 (1992).

• Fu YF, Zhu YN, Ni J, Zhong XG, Tang W, Re YD, Shi LP, Wan J, Yang YF, Yuan C, Nan FJ, Lawson BR, Zuo JP. A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation. J. Pharmacol. Exp. Ther. 319: 799-808 (2006). *

• Fujimaki C, Hayashi H, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Inoue K, Itoh K. Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis. Biomarkers 14: 49-54 (2009).

• Fukada SI, Morita T, Sugiyama K. Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats. Biosci. Biotechnol. Biochem. 72: 1940-1943 (2008). *

• Fukagawa NK, Martin JM, Wurthmann A, Prue AH, Ebenstein D, O'Rourke B. Sex-related differences in methionine metabolism and plasma homocysteine concentrations. Am. J. Clin. Nutr. 72: 22-29 (2000). *

• Fumic K, Beluzic R, Cuk M, Pavkov T, Kloor D, Baric I, Mijic I, Vugrek O. Functional analysis of human S-adenosylhomocysteine hydrolase isoforms SAHH-2 and SAHH-3. Eur. J. Hum. Genet. 15: 347-351 (2007). *

• Gaede PH. Intensified multifactorial intervention in patients with type 2 diabetes and microalbuminuria: rationale and effect on late-diabetic complications. Dan. Med. Bull. 53: 258-284 (2006).

• Gallegos-Arreola MP, García-Ortiz JE, Figuera LE, Puebla-Perez AM, Morgan-Villela G, Zuniga-Gonzalez GM. Association of the 677C ->T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients. Cancer Genomics Proteomics 6: 183-188 (2009).

• Ganapathy P, Moister B, Roon P, Mysona B, Duplantier JN, Dun Y, Moister TV, Farley MJ, Prasad PD, Liu K, Smith SB. Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse. Invest. Ophthalmol. Vis. Sci. 50: 4460-4470 (2009). *

• Ganji V, Kafai MR. Demographic, lifestyle, and health characteristic and serum B vitamin status determinants of plasma total homocysteine concentration in the post-folic acid fortification period, 1999-2004. J. Nutr. 139: 345-352 (2009). *

• Gao P, Lu C, Zhang F, Sang P, Yang D, Li X, Kong H, Yin P, Tian J, Lu X, Lu A, Xu G. Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis. Analyst 133: 1214-1220 (2008). *

• García Ribes A, Martinez Gonzalez M, García Cazorla A. Adult-onset metabolic diseases. An. Sist. Sanit. Navar. 31 Suppl. 2: 75-89 (2008).

• Garcia-Tevijano ER, Berasain C, Rodriguez JA, Corrales FJ, Arias R, Martin-Duce A, Caballeria J, Mato JM, Avila MA. Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis. Hypertension 38: 1217-1221 (2001). *

• Garibotto G, Valli A, Anderstam B, Eriksson M, Suliman ME, Balbi M, Rollando D, Vigo E, Lindholm B. The kidney is the major site of S-adenosylhomocysteine disposal in humans. Kidney Int. 76: 293-296 (2009). *

• Gast A, Bermejo JL, Flohr T, Stanulla M, Burwinkel B, Schrappe M, Bartram CR, Hemminki K, Kumar R. Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study. Leukemia 21: 320-325 (2007).

• Gates AT, Fakayode SO, Lowry M, Ganea GM, Murugeshu A, Robinson JW, Strongin RM, Warner IM. Gold nanoparticle sensor for homocysteine thiolactone-induced protein modification. Langmuir 24: 4107-4113 (2008).

• Gaughan DJ, Kluijtmans LA, Barbaux S, McMaster D, Young IS, Yarnell JW, Evans A, Whitehead AS. The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 157: 451-456 (2001).

• Gaysina D, Cohen S, Craddock N, Farmer A, Hoda F, Korszun A, Owen MJ, Craig IW, McGuffin P. No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 147B: 699-706 (2008).

• Gellekink H, Blom HJ, van der Linden IJ, den Heijer M. Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. Eur. J. Hum. Genet. 15: 103-109 (2007). *

• Ghazouani L, Abboud N, Mtiraoui N, Zammiti W, Addad F, Amin H, Almawi WY, Mahjoub T. Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease. J. Thromb. Thrombolysis 27: 191-197 (2009).

• Ghorbanihaghjo A, Javadzadeh A, Argani H, Nezami N, Rashtchizadeh N, Rafeey M, Rohbaninoubar M, Rahimi-Ardabili B. Lipoprotein(a), homocysteine, and retinal arteriosclerosis. Mol. Vis. 14: 1692-1697 (2008). *

• Gibson A, Woodside JV, Young IS, Sharpe PC, Mercer C, Patterson CC, McKinley MC, Kluijtmans LA, Whitehead AS, Evans A. Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers - a randomized, crossover intervention study. QJM 101: 881-887 (2008).

• Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan-Crow LA, Blossom SJ. Delineating liver events in trichloroethylene-induced autoimmune hepatitis. Chem. Res. Toxicol. 22: 626-632 (2009). *

• Girish BN, Vaidyanathan K, Rao NA, Rajesh G, Reshmi S, Balakrishnan V. Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways. Pancreas 39: e11-e16 (2010).

• Gisondi P, Fantuzzi F, Malerba M, Girolomoni G. Folic acid in general medicine and dermatology. J. Dermatolog. Treat. 18: 138-146 (2007).

• Gisondi P, Girolomoni G. Psoriasis and atherothrombotic diseases: disease-specific and non-disease-specific risk factors. Semin. Thromb. Hemost. 35: 313-324 (2009).

• Giusti B, Sestini I, Saracini C, Sticchi E, Bolli P, Magi A, Gori AM, Marcucci R, Gensini GF, Abbate R. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. Biochem. Genet. 46: 406-423 (2008). *

• Gladd DA, Olech E. Antiphospholipid antibodies in rheumatoid arthritis: identifying the dominoes. Curr. Rheumatol. Rep. 11: 43-51 (2009).

• Glueck CJ, Pranikoff J, Aregawi D, Haque M, Zhu B, Tracy T, Wang P. The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriage. Metabolism 54: 1345-1349 (2005).

• Gogolauri M, Antelava N. Effect of heptral and folic acid on the hepatic functions during toxic hepatitis. Georgian Med. News 6: 57-60 (2005).

• Goncalves M, D'Almeida V, Guerra-Shinohara EM, Galdieri LC, Len CA, Hilario MO. Homocysteine and lipid profile in children with juvenile idiopathic arthritis. Pediatr. Rheumatol. Online J. 5: 2 (2007). *

• Gong Z, Yan S, Zhang P, Huang Y, Wang L. Effects of S-adenosylmethionine on liver methionine metabolism and steatosis with ethanol-induced liver injury in rats. Hepatol. Int. 2: 346-352 (2008). *

• Gonul M, Gul U, Kilinc C, Cakmak SK, Soylu S, Kilic A. Homocysteine levels in patients with Behcet's disease and patients with recurrent aphthous stomatitis. Clin. Rheumatol. 28: 1153-1156 (2009). *

• Gonzalez-Lopez L, Sanchez-Hernandez JD, Aguilar-Chavez EA, Cota-Sanchez AR, Lopez-Olivo MA, Villa-Manzano AI, Ortega-Flores R, Espinoza-Magana GL, Rojo-Contreras W, Cardona-Munoz EG, Gamez-Nava JI. Hyperhomocysteinemia in ankylosing spondylitis: prevalence and association with clinical variables. Rheumatol. Int. 28: 1223-1228 (2008). *

• Gonzalez-Porras JR, Martin-Herrero F, Garcia-Sanz R, Lopez ML, Balanzategui A, Mateos MV, Pavon P, Gonzalez M, Alberca I, San Miguel JF. Hyperhomocysteinemia is a risk factor of recurrent coronary event in young patients irrespective to the MTHFR C677T polymorphism. Thromb. Res. 119: 691-698 (2007). *

• Gopinath B, Wang JJ, Flood VM, Burlutsky G, Wong TY, Mitchell P. The associations between blood levels of homocysteine, folate, vitamin B(12), and retinal vascular caliber. Am. J. Ophthalmol. 148: 902-909 (2009). *

• Goracy I, Cyrylowski L, Kaczmarczyk M, Fabian A, Koziarska D, Goracy J, Ciechanowicz A. C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects. J. Appl. Genet. 50: 63-67 (2009). *

• Goren JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 24: 1501-1507 (2004).

• Gorgone G, Caccamo D, Pisani LR, Curro M, Parisi G, Oteri G, Ientile R, Rossini PM, Pisani F. Hyperhomocysteinemia in patients with epilepsy: does it play a role in the pathogenesis of brain atrophy? A preliminary report. Epilepsia 50 Suppl. 1: 33-36 (2009).

• Gorgone G, Ursini F, Altamura C, Bressi F, Tombini M, Curcio G, Chiovenda P, Squitti R, Silvestrini M, Ientile R, Pisani F, Rossini PM, Vernieri F. Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment. Atherosclerosis 206: 309-313 (2009).

• Greco M, Chiriaco F, Del Boccio P, Tagliaferro L, Acierno R, Menegazzi P, Pinca E, Pignatelli F, Storelli C, Federici G, Urbani A, Maffia M. A proteomic approach for the characterization of C677T mutation of the human gene methylenetetrahydrofolate reductase. Proteomics 6: 5350-5361 (2006). *

• Green R. Is it time for vitamin B-12 fortification? What are the questions? Am. J. Clin. Nutr. 89: 712S-716S (2009). *

• Green R. Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies. Food Nutr. Bull. 29: S52-S63 (2008).

• Green TJ, Skeaff CM, McMahon JA, Venn BJ, Williams SM, Devlin AM, Innis SM. Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations. Br. J. Nutr. Jan 21 [Epub ahead of print] (2010). *

• Grillo MA, Colombatto S. S-Adenosylmethionine and its products. Amino Acids 34: 187-193 (2008). *

• Gross M, Friedman G, Eliashar R, Koren-Morag N, Goldschmidt N, Atta IA, Ben-Yehuda A. Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss. Audiol. Neurootol. 11: 287-293 (2006).

• Gu W, Lu J, Yang G, Dou J, Mu Y, Meng J, Pan C. Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2 diabetes mellitus. Adv. Ther. 25: 914-924 (2008).

• Guaraldi G, Ventura P, Garlassi E, Orlando G, Squillace N, Nardini G, Stentarelli C, Zona S, Marchini S, Moriondo V, Tebas P. Hyperhomocysteinaemia in HIV-infected patients: determinants of variability and correlations with predictors of cardiovascular disease. HIV Med. 10: 28-34 (2009).

• Gueant JL, Xiaohong L, Ortiou S, Gerard P, Shue S, Namour F. The association between plasma homocysteine and holo-transcobalamin and the transcobalamin 776C->G polymorphism is influenced by folate in the absence of supplementation and fortified diet. Am. J. Clin. Nutr. 83: 171-172 (2006). *

• Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sanchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am. J. Clin. Nutr. 83: 701-707 (2006). *

• Gupta S, Kuhnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 23: 883-893 (2009). *

• Hadithi M, Mulder CJ, Stam F, Azizi J, Crusius JB, Pena AS, Stehouwer CD, Smulders YM. Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. World J. Gastroenterol. 15: 955-960 (2009). *

• Haghighatgoo A, Valles-Ayoub Y, Saechao C, Esfandiarifard S, Martinez SL, Pietruszka M, Darvish D. MTHFR C677T genotype frequency in patients of Middle Eastern descent as determined by real-time PCR and melting curve analysis. Genet. Test. Mol. Biomarkers 13: 471-476 (2009).

• Hallert C, Svensson M, Tholstrup J, Hultberg B. Clinical trial: B vitamins improve health in coeliac patients living on a gluten-free diet. Aliment. Pharmacol. Ther. 29: 811-816 (2009). *

• Halsted CH, Villanueva JA, Devlin AM. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol 27: 169-172 (2002). *

• Halsted CH, Villanueva JA, Devlin AM, Niemela O, Parkkila S, Garrow TA, Wallock LM, Shigenaga MK, Melnyk S, James SJ. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc. Natl. Acad. Sci. U.S.A. 99: 10072-10077 (2002). *

• Halsted CH, Wong DH, Peerson JM, Warden CH, Refsum H, Smith AD, Nygard OK, Ueland PM, Vollset SE, Tell GS. Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 86: 514-521 (2007). *

• Hambaba L, Abdessemed S, Yahia M, Laroui S, Rouabah F. Relationship between hyperhomocysteinemia and C677T polymorphism of methylene tetrahydrofolate reductase gene in a healthy Algerian population. Ann. Biol. Clin. (Paris) 66: 637-641 (2008).

• Hamelahti P, Jarvinen O, Sisto T, Wirta V, Ilveskoski E, Koivula T, Lehtimaki T. Methylenetetrahydrofolate reductase gene C677T mutation is related to the defects in the internal elastic lamina of the artery wall. Eur. J. Clin. Invest. 32: 869-873 (2002).

• Hamelet J, Demuth K, Paul JL, Delabar JM, Janel N. Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice. J. Hepatol. 46: 151-159 (2007). *

• Hamelet J, Seltzer V, Petit E, Noll C, Andreau K, Delabar JM, Janel N. Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver. Biochim. Biophys. Acta 1782: 482-488 (2008). *

• Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS. Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. Clin. Immunol. 133: 132-137 (2009). *

• Han Q, Hoffman RM. Nonradioactive enzymatic assay for plasma and serum vitamin B(6). Nat. Protoc. 3: 1815-1819 (2008). *

• Hanson NQ, Aras O, Yang F, Tsai MY. C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin. Chem. 47: 661-666 (2001). *

• Haque S, Bruce IN. Therapy insight: systemic lupus erythematosus as a risk factor for cardiovascular disease. Nat. Clin. Pract. Cardiovasc. Med. 2: 423-430 (2005).

• Harats D, Yodfat O, Doolman R, Gavendo S, Marko D, Shaish A, Sela BA. Homocysteine elevation with fibrates: is it a class effect? Isr. Med. Assoc. J. 3: 243-246 (2001). *

• Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P, Selhub J, Hunter DJ. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum. Mol. Genet. 18: 4677-4687 (2009).

• He JA, Hu XH, Fan YY, Yang J, Zhang ZS, Liu CW, Yang DH, Zhang J, Xin SJ, Zhang Q, Duan ZQ. Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis. Eur. J. Vasc. Endovasc. Surg. Oct 19 [Epub ahead of print] (2009).

• Hebuterne X, Filippi J, Al-Jaouni R, Schneider S. Nutritional consequences and nutrition therapy in Crohn's disease. Gastroenterol. Clin. Biol. 33S3: S235-S244 (2009).

• Heil SG, Vermeulen SH, Van der Rijt-Pisa BJ, den Heijer M, Blom HJ. Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk? Clin. Chem. Lab. Med. 46: 655-659 (2008). *

• Heill SG, Vermeulen SH, Van der Rijt-Pisa BJ, den Heijer M, Blom HJ. Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk? Clin. Chem. Lab. Med. 46: 655-659 (2008).

• Heneghan HM, Sultan S. Homocysteine, the cholesterol of the 21st century. Impact of hyperhomocysteinemia on patency and amputation-free survival after intervention for critical limb ischemia. J. Endovasc. Ther. 15: 399-407 (2008).

• Henkel AS, Elias MS, Green RM. Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis. J. Biol. Chem. 284: 31807-31816 (2009). *

• Herbig K, Chiang EP, Lee LR, Hills J, Shane B, Stover PJ. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J. Biol. Chem. 277: 38381-3839 (2002). *

• Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, Taban-Shomal O, Umanskaya N, Ross S, Garcia P, Hubner U, Herrmann W. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone 44: 467-475 (2009). *

• Herrmann M, Wildemann B, Wagner A, Wolny M, Schorr H, Taban-Shomal O, Umanskaya N, Ross S, Garcia P, Hubner U, Herrmann W. Experimental folate and vitamin B12 deficiency does not alter bone quality in rats. J. Bone Miner. Res. 24: 589-596 (2009). *

• Herrmann W, Lorenzl S, Obeid R. Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders. Fortschr. Neurol. Psychiatr. 75: e1-e18 (2007).

• Herrmann W, Obeid R, Schorr H, Hubner U, Geisel J, Sand-Hill M, Ali N, Herrmann M. Enhanced bone metabolism in vegetarians - the role of vitamin B12 deficiency. Clin. Chem. Lab. Med. 47: 1381-1387 (2009). *

• Herrmann W, Schorr H, Obeid R, Makowski J, Fowler B, Kuhlmann MK. Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes. Clin. Chem. 51: 891-897 (2005). *

• Hirabayashi Y, Oka Y, Ikeda T, Fujii H, Ishii T, Sasaki T, Harigae H. The endoplasmic reticulum stress-inducible protein, Herp, is a potential triggering antigen for anti-DNA response. J. Immunol. Feb 10 [Epub ahead of print] (2010).

• Hiukka A, Leinonen E, Jauhiainen M, Sundvall J, Ehnholm C, Keech AC, Taskinen MR. Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus. Diabetologia 50: 2067-2075 (2007). *

• Ho CH, Kuo BI, Kong CW, Chau WK, Hsu HC, Gau JP, Yu YB. Influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, B vitamins and other factors on plasma homocysteine and risk of thromboembolic disease in Chinese. J. Chin. Med. Assoc. 68: 560-565 (2005).

• Hodis HN, Mack WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J, Alaupovic P, Liu CR, Liu CH, Hwang J, Wilcox AG, Selzer RH; for the BVAIT Research Group. High-dose B vitamin supplementation and progression of subclinical atherosclerosis. A randomized controlled trial. Stroke 40: 730-736 (2009).

• Hogarth LA, Redfern CP, Teodoridis JM, Hall AG, Anderson H, Case MC, Coulthard SA. The effect of thiopurine drugs on DNA methylation in relation to TPMT expression. Biochem. Pharmacol. 76: 1024-1035 (2008). *

• Holm PI, Hustad S, Ueland PM, Vollset SE, Grotmol T, Schneede J. Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->T genotypes and B-vitamin status in a large scale epidemiological study. J. Clin. Endocrinol. Metab. 92: 1535-1541 (2007). *

• Hong L, Fast W. Inhibition of human dimethylarginine dimethylamionhydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide: analysis, quantification, and implications for hyperhomocysteinemia. J. Biol. Chem. 282: 34684-34692 (2007). *

• Hooijmans CR, Blom HJ, Oppenraaij-Emmerzaal D, Ritskes-Hoitinga M, Kiliaan AJ. S-Adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice. Neurol. Sci. 30: 439-445 (2009).

• Horvath B, Szapary L, Debreceni L, Feher G, Kenyeres P, Fulop A, Battyani I, Toth K. Effect of Sclerovit on endothelial dysfunction, hemorheological parameters, platelet aggregation, plasma concentration of homocysteine and progression of atherosclerosis in patients with vascular diseases. Clin. Hemorheol. Microcirc. 42: 19-28 (2009).

• Hotoleanu C, Andercou O, Andercou A. Mesenteric venous thrombosis with bowel infarction and hyperhomocysteinemia due to homozygous methylenetetrahydrofolate reductase C677T genotype. Vasc. Endovascular Surg. 42: 477-481 (2008).

• Hotoleanu C, Porojan-Iuga M, Rusu ML, Andercou A. Hyperhomocysteinemia: clinical and therapeutical involvement in venous thrombosis. Rom. J. Intern. Med. 45: 159-164 (2007).

• Hsu JF, Chuang WJ, Shiesh SC, Lin YS, Liu CC, Wang CC, Fu TF, Tsai JH, Tsai WL, Huang YJ, Hsieh YH, Wu JJ, Lin MT, Huang W. Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia. J. Infect. Dis. 198: 367-374 (2008). *

• Huang CC, Tseng WL. Role of fluorosurfactant-modified gold nanoparticles in selective detection of homocysteine thiolactone: remover and sensor. Anal. Chem. 80: 6345-6350 (2008). *

• Huang T, Wahlqvist ML, Li D. Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism. Nutrition 26: 112-119 (2010).

• Huang Y, Ji L, Huang Q, Vassylyev DG, Chen X, Ma JB. Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature 461: 823-827 (2009). *

• Huang YS, Zhi YF, Wang SR. Hypermethylation of estrogen receptor-alpha gene in atheromatosis patients and its correlation with homocysteine. Pathophysiology 16: 259-265 (2009).

• Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Batge B, Notbohm H, Reinhardt DP. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria. J. Biol. Chem. 280: 34946-34955 (2005). *

• Huemer M, Huemer C, Ulmer H, Crone J, Fodinger M, Falger J, Sailer-Hock M. No evidence for hyperhomocysteinemia or increased prevalence of genetic polymorphisms in the homocysteine pathway in patients with moderate juvenile idiopathic arthritis. J. Rheumatol. 32: 170-174 (2005).

• Huemer M, Simma B, Fowler B, Suormala T, Bodamer OA, Sass JO. Prenatal and postnatal treatment in cobalamin C defect. J. Pediatr. 147: 469-472 (2005). *

• Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin. Proc. 83: 1203-1212 (2008).

• Hustad S, Midttun O, Schneede J, Vollset SE, Grotmol T, Ueland PM. The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am. J. Hum. Genet. 80: 846-855 (2007). *

• Hustad S, Nedrebo BG, Ueland PM, Schneede J, Vollset SE, Ulvik A, Lien EA. Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction. Am. J. Clin. Nutr. 80: 1050-1057 (2004). *

• Ientile R, Curro' M, Ferlazzo N, Condello S, Caccamo D, Pisani F. Homocysteine, vitamin determinants and neurological diseases. Front. Biosci. (Schol. Ed.) 2: 359-372 (2010).

• Ifergan I, Assaraf YG. Chapter 4. Molecular mechanisms of adaptation to folate deficiency. Vitam. Horm. 79: 99-143 (2008).

• Igolnikov AC, Green RM. Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. J. Hepatol. 44: 586-592 (2006). *

• Ilhan N, Kucuksu M, Kaman D, Ilhan N, Ozbay Y. The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch. Med. Res. 39: 125-130 (2008).

• Ingrosso D, Perna AF. Epigenetics in hyperhomocysteinemic states. A special focus on uremia. Biochim. Biophys. Acta 1790: 892-899 (2009). *

• Innis SM, Davidson AG. Cystic fibrosis and nutrition: linking phospholipids and essential fatty acids with thiol metabolism. Annu. Rev. Nutr. 28: 55-72 (2008). *

• Innis SM, Davidson AG, Chen A, Dyer R, Melnyk S, James SJ. Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis. J. Pediatr. 143: 351-356 (2003). *

• Innis SM, Davidson AG, Melynk S, James SJ. Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. Am. J. Clin. Nutr. 85: 702-708 (2007). *

• Innis SM, Hasman D. Evidence of choline depletion and reduced betaine and dimethylglycine with increased homocysteine in plasma of children with cystic fibrosis. J. Nutr. 136: 2226-2231 (2006). *

• Isa Y, Mishima T, Tsuge H, Hayakawa T. Increase in S-adenosylhomocysteine content and its effect on the S-adenosylhomocysteine hydrolase activity under transient high plasma homocysteine levels in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 52: 479-482 (2006). *

• Jacob T, Hingorani A, Ascher E. Evidence for telomerase activation in VSMCs exposed to hyperglycemic and hyperhomocysteinemic conditions. Angiology 60: 562-568 (2009).

• Jacovina AT, Deora AB, Ling Q, Broekman MJ, Almeida D, Greenberg CB, Marcus AJ, Smith JD, Hajjar KA. Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. J. Clin. Invest. 119: 3384-3394 (2009). *

• Jakobkiewicz-Banecka J, Kloska A, Stepnowska M, Banecki B, Wegrzyn A, Wegrzyn G. A bacterial model for studying effects of human mutations in vivo: Escherichia coli strains mimicking a common polymorphism in the human MTHFR gene. Mutat. Res. 578: 175-186 (2005).

• Jakubowski H. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. J. Physiol. Pharmacol. 59 Suppl. 9: 155-167 (2008). *

• Jakubowski H. New method for the determination of protein N-linked homocysteine. Anal. Biochem. 380: 257-261 (2008). *

• Jakubowski H. The molecular basis of homocysteine thiolactone-mediated vascular disease. Clin. Chem. Lab. Med. 45: 1704-1716 (2007). *

• Jakubowski H, Boers GH, Strauss KA. Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB J. 22: 4071-4076 (2008). *

• Jakubowski H, Perla-Kajan J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J. 23: 1721-1727 (2009).

• James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr. 80: 1611-1517 (2004). *

• Janosikova B, Pavlikova M, Kocmanova D, Vitova A, Vesela K, Krupkova L, Kahleova R, Krijt J, Kraml P, Hyanek J, Zvarova J, Andel M, Kozich V. Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Mol. Genet. Metab. 79: 167-175 (2003). *

• Janosikova B, Zavadakova P, Kozich V. Single-nucleotide polymorphisms in genes relating to homocysteine metabolism: how applicable are public SNP databases to a typical European population? Eur. J. Hum. Genet. 13: 86-95 (2005). *

• Jax T, Lauer T. The art of primary prevention and risk assessment. Homocysteine revisited. Stroke 40: 670-671 (2009).

• Jemaa R, Achouri A, Kallel A, Ali SB, Mourali S, Feki M, Elasmi M, Taieb SH, Sanhaji H, Omar S, Mechmeche R, Kaabachi N. Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients. Clin. Chem. Lab. Med. 46: 1364-1368 (2008).

• Jensen LE, Wall AM, Cook M, Hoess K, Thorn CF, Whitehead AS, Mitchell LE. A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida. Birth Defects Res. Part A. Clin. Mol. Teratol. 70: 396-399 (2004). *

• Jensen LH, Lindebjerg J, Cruger DG, Brandslund I, Jakobsen A, Kolvraa S, Nielsen JN. Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer. Cancer Invest. 26: 583-589 (2008).

• Ji C, Deng Q, Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 40: 442-451 (2004). *

• Ji C, Kaplowitz N. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J. Gastroenterol. 10: 1699-1708 (2004). *

• Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124: 1488-1499 (2003). *

• Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N. Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology 46: 1586-1596 (2007). *

• Jiang Y, Zhang J, Xiong J, Cao J, Li G, Wang S. Ligands of peroxisome proliferator-activated receptor inhibit homocysteine-induced DNA methylation of inducible nitric oxide synthase gene. Acta Biochim. Biophys. Sin. (Shanghai) 39: 366-376 (2007).

• Jonkers IJ, de Man FH, Onkenhout W, van der Laarse A, Smelt AH. Implication of fibrate therapy for homocysteine. Lancet 354: 1208 (1999).

• Jung YS, Kwak HE, Choi KH, Kim YC. Effect of acute ethanol administration on S-amino acid metabolism: increased utilization of cysteine for synthesis of taurine rather than glutathione. Adv. Exp. Med. Biol. 526: 245-252 (2003).

• Kageyama M, Hiraoka M, Kagawa Y. Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease. Asia Pac. J. Public Health 20: S111-S117 (2008).

• Kale A, Naphade N, Sapkale S, Kamaraju M, Pillai A, Joshi S, Mahadik S. Reduced folic acid, vitamin B(12) and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res. Dec 5 [Epub ahead of print] (2009).

• Kalmbach RD, Choumenkovitch SF, Troen AP, Jacques PF, D'Agostino R, Selhub J. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J. Nutr. 138: 2323-2327 (2008). *

• Kalogeropoulos N, Panagiotakos DB, Pitsavos C, Chrysohoou C, Rousinou G, Toutouza M, Stefanadis C. Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults. Clin. Chim. Acta. Jan 21 [Epub ahead of print] (2010). *

• Kalra S, Ahuja R, Binion DG, Seetharam S, Seetharam B. Upregulation of transcobalamin (TC) and its receptor in colonic inflammation: effect of homocysteine. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G918 (2007). *

• Kao A, Dlugos D, Hunter JV, Mamula P, Thorarensen O. Anticoagulation therapy in cerebral sinovenous thrombosis and ulcerative colitis in children. J. Child. Neurol. 17: 479-482 (2002).

• Kapoor P, Ansari MN, Bhandari U. Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats. Indian J. Exp. Biol. 46: 534-540 (2008).

• Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm. Venereol. 88: 337-340 (2008).

• Karakula H, Opolska A, Kowal A, Domanski M, Plotka A, Perzynski J. Does diet affect our mood? The significance of folic acid and homocysteine. Pol. Merkur. Lekarski. 26: 136-141 (2009).

• Karasu E, Sadan G, Tasatargil A. Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum. Dig. Dis. Sci. 53: 2106-2112 (2008). *

• Karolczak K, Olas B. Mechanism action of homocysteine and its thiolactone in haemostasis system. Physiol. Res. 58: 623-633 (2009). *

• Kartal Durmazlar SP, Akgul A, Eskioglu F. Hyperhomocysteinemia in patients with stasis dermatitis and ulcer: a novel finding with important therapeutic implications. J. Dermatolog. Treat. Jan 1 [Epub ahead of print] (2009).

• Kartal Durmazlar SP, Akgul A, Eskioglu F. Homocysteine may involve in the pathogenesis of Behcet's disease by inducing inflammation. Mediators Inflamm. 2008: 407972 (2008). *

• Kassab A, Ajmi T, Issaoui M, Chaeib L, Miled A, Hammami M. Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes. Ann. Clin. Biochem. 45: 476-480 (2008).

• Kawakami Y, Ohuchi S, Morita T, Sugiyama K. Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels. J. Nutr. Sci. Vitaminol. (Tokyo) 55: 66-74 (2009). *

• Kealey C, Brown KS, Woodside JV, Young I, Murray L, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS. A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations. Hum. Genet. 116: 347-353 (2005). *

• Kelly GS. Folates: supplemental forms and therapeutic applications. Altern. Med. Rev. 3: 208-220 (1998). *

• Kelly TL, Neaga OR, Schwahn BC, Rozen R, Trasler JM. Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Biol. Reprod. 72: 667-677 (2005). *

• Kemperman RF, Veurink M, van der Wal T, Knegtering H, Bruggeman R, Fokkema MR, Kema IP, Korf J, Muskiet FA. Low essential fatty acid and B-vitamin status in a subgroup of patients with schizophrenia and its response to dietary supplementation. Prostaglandins Leukot. Essent. Fatty Acids 74: 75-85 (2006). *

• Kerekes G, Szekanecz Z, Der H, Sandor Z, Lakos G, Muszbek L, Csipo I, Sipka S, Seres I, Paragh G, Kappelmayer J, Szomjak E, Veres K, Szegedi G, Shoenfeld Y, Soltesz P. Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity. J. Rheumatol. 35: 398-406 (2008).

• Kerkeni M, Addad F, Chauffert M, Chuniaud L, Miled A, Trivin F, Maaroufi K. Hyperhomocysteinemia, paraoxonase activity and risk of coronary artery disease. Clin. Biochem. 39: 821-825 (2006). *

• Kerkeni M, Addad F, Chauffert M, Myara A, Gerhardt M, Chevenne D, Trivin F, Farhat MB, Miled A, Maaroufi K. Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease. Ann. Clin. Biochem. 43: 200-206 (2006).

• Kerr MA, Livingstone B, Bates CJ, Bradbury I, Scott JM, Ward M, Pentieva K, Mansoor MA, McNulty H. Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life. Pediatrics 123: 627-635 (2009). *

• Key TJ, Appleby PN, Rosell MS. Health effects of vegetarian and vegan diets. Proc. Nutr. Soc. 65: 35-41 (2006). *

• Kharbanda KK, Mailliard ME, Baldwin CR, Beckenhauer HC, Sorrell MF, Tuma DJ. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J. Hepatol. 46: 314-321 (2007). *

• Kharbanda KK, Mailliard ME, Baldwin CR, Sorrell MF, Tuma DJ. Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-l-isoaspartyl methyltransferase activity. J. Hepatol. 46: 1119-1125 (2007). *

• Kharbanda KK, Rogers DD 2nd, Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, Sorrell MF, Tuma DJ. A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes. J. Nutr. 135: 519-524 (2005). *

• Kharbanda KK, Rogers DD 2nd, Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, Sorrell MF, Tuma DJ. Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem. Pharmacol. 70: 1883-1890 (2005). *

• Kiani S, Ebrahimkhani MR, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR. Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis. J. Gastroenterol. Hepatol. 22: 406-413 (2007). *

• Kidd PM. Integrated brain restoration after ischemic stroke - medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity. Altern. Med. Rev. 14: 14-35 (2009).

• Kifle L, Ortiz D, Shea TB. Deprivation of folate and B12 increases neurodegeneration beyond that accompanying deprivation of either vitamin alone. J. Alzheimers Dis. 16: 533-540 (2009).

• Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Shin HY, Yoon JS. Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans. Int. J. Geriatr. Psychiatry 23: 454-459 (2008).

• Kim OJ, Hong SP, Ahn JY, Hong SH, Hwang TS, Kim SO, Yoo W, Oh D, Kim NK. Influence of combined methionine synthase (MTR 2756A > G) and methylenetetrahydrofolate reductase (MTHFR 677C > T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke. Yonsei. Med. J. 48: 201-209 (2007). *

• Kim SJ, Lee JW, Jung YS, Kwon DY, Park HK, Ryu CS, Kim SK, Oh GT, Kim YC. Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice. J. Hepatol. 50: 1184-1191 (2009).

• Kim SK, Kim YC. Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice. J. Hepatol. 42: 907-913 (2005). *

• Kim YC, Jung YS, Kim SK. Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate. Food Chem. Toxicol. 43: 663-670 (2005). *

• Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol. Biomarkers Prev. 13: 511-519 (2004). *

• Kirsch SH, Knapp JP, Geisel J, Herrmann W, Obeid R. Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877: 3865-3870 (2009). *

• Kiseljakovic E, Jadric R, Hasic S, Skenderi F, Resic H, Winterhalter-Jadric M. Polymorphism in methylentetra-hydrofolate reductase gene: important role in diseases. Bosn. J. Basic Med. Sci. 8: 165-169 (2008).

• Kitamura Y, Kusuhara H, Sugiyama Y. Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse. Pharm. Res. Feb 11 [Epub ahead of print] (2010). *

• Kleiser C, Mensink GB, Scheidt-Nave C, Kurth BM. HuSKY: a healthy nutrition score based on food intake of children and adolescents in Germany. Br. J. Nutr. 102: 610-618 (2009). *

• Klevay LM. Homocysteine is not so paradoxical. Arterioscler. Thromb. Vasc. Biol. 28: e160 (2008).

• Kloor D, Karnahl K, Kompf J. Characterization of glycine N-methyltransferase from rabbit liver. Biochem. Cell. Biol. 82: 369-374 (2004).

• Kloor D, Osswald H. S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action. Trends Pharmacol. Sci. 25: 294-297 (2004). *

• Knoops KT, Spiro A, de Groot LC, Kromhout D, van Staveren WA, Tucker KL. Do dietary patterns in older men influence change in homocysteine through folate fortification? The normative aging study. Public Health Nutr. 12: 1760-1766 (2009).

• Ko K, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC. Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab. Invest. 88: 1121-1129 (2008). *

• Ko KH, Kim NK, Yim DJ, Hong SP, Park PW, Rim KS, Kim S, Hwang SG. Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population. Anticancer Res. 26: 4229-4233 (2006).

• Kocer B, Engur S, Ak F, Yilmaz M. Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis. J. Clin. Neurosci. 16: 399-403 (2009).

• Korkmaz C, Bozan B, Kosar M, Sahin F, Gulbas Z. Is there an association of plasma homocysteine levels with vascular involvement in patients with Behcet's syndrome? Clin. Exp. Rheumatol. 20: S30-S34 (2002).

• Koubaa N, Hammami S, Nakbi A, Ben Hamda K, Mahjoub S, Kosaka T, Hammami M. Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behcet's disease patients. Clin. Chem. Lab. Med. 46: 187-192 (2008). *

• Koubaa N, Nakbi A, Hammami S, Attia N, Mehri S, Hamda KB, Farhat MB, Miled A, Hammami M. Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome. Clin. Biochem. 42: 771-776 (2009). *

• Kountouras J, Gavalas E, Zavos C, Stergiopoulos C, Chatzopoulos D, Kapetanakis N, Gisakis D. Alzheimer's disease and Helicobacter pylori infection: defective immune regulation and apoptosis as proposed common links. Med. Hypotheses 68: 378-388 (2007).

• Koutmos M, Datta S, Pattridge KA, Smith JL, Matthews RG. Insights into the reactivation of cobalamin-dependent methionine synthase. Proc. Natl. Acad. Sci. U.S.A. 106: 18527-18532 (2009). *

• Koutroubakis IE. Therapy insight: vascular complications in patients with inflammatory bowel disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2: 266-272 (2005). *

• Koutroubakis IE, Dilaveraki E, Vlachonikolis IG, Vardas E, Vrentzos G, Ganotakis E, Mouzas IA, Gravanis A, Emmanouel D, Kouroumalis EA. Hyperhomocysteinemia in Greek patients with inflammatory bowel disease. Dig. Dis. Sci. 45: 2347-2351 (2000). *

• Krajcovicova-Kudlackova M, Blazicek P, Mislanova C, Valachovicova M, Paukova V, Spustova V. Nutritional determinants of plasma homocysteine. Bratisl. Lek. Listy. 108: 510-515 (2007).

• Krieg EF Jr, Butler MA, Chang MH, Liu T, Yesupriya A, Lindegren ML, Dowling N; for the CDC/NCI NHANES III Genomics Working Group. Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol. Teratol. Dec 14 [Epub ahead of print] (2009).

• Krogh Jensen M, Ekelund S, Svendsen L. Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis. Scand. J. Clin. Lab. Invest. 56: 421-429 (1996).

• Krupanidhi S, Sedimbi SK, Vaishnav G, Madhukar SS, Sanjeevi CB. Diabetes - role of epigenetics, genetics, and physiological factors. Zhong Nan Da Xue Xue Bao Yi Xue Ban 34: 837-845 (2009).

• Kruse L, Mitchell AM, Camargo CA Jr, Hernandez J, Kline JA. Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department. Clin. Chem. 52: 1026-1032 (2006). *

• Kumar N, Armstrong DJ. Cardiovascular disease - the silent killer in rheumatoid arthritis. Clin. Med. 8: 384-387 (2008).

• Kundu S, Kumar M, Sen U, Mishra PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi SC. Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice. J. Cell. Biochem. 106: 119-126 (2008). *

• Lane NE. Therapy insight: osteoporosis and osteonecrosis in systemic lupus erythematosus. Nat. Clin. Pract. Rheumatol. 2: 562-569 (2006). *

• Lanska DJ. Chapter 30. Historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. Handb. Clin. Neurol. 95: 445-476 (2009).

• Lawrance AK, Deng L, Rozen R. Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apcmin/+ mice. Gut 58: 805-811 (2009).

• Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN, Yuan C. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system. J. Immunol. 178: 5366-5374 (2007). *

• Lawson-Yuen A, Levy HL. The use of betaine in the treatment of elevated homocysteine. Mol. Genet. Metab. 88: 201-207 (2006). *

• Lazzerini PE, Capecchi PL, Bisogno S, Cozzalupi M, Rossi PC, Laghi Pasini F. Homocysteine and Raynaud's phenomenon: a review. Autoimmun. Rev. Aug 15 [Epub ahead of print] (2009).

• Lazzerini PE, Capecchi PL, Selvi E, Lorenzini S, Bisogno S, Galeazzi M, Laghi Pasini F. Hyperhomocysteinemia: a cardiovascular risk factor in autoimmune diseases? Lupus 16: 852-862 (2007). *

• Lazzerini PE, Capecchi PL, Selvi E, Lorenzini S, Bisogno S, Galeazzi M, Laghi Pasini F. Hyperhomocysteinemia, inflammation and autoimmunity. Autoimmun. Rev. 6: 503-509 (2007).

• Lazzerini PE, Selvi E, Lorenzini S, Capecchi PL, Ghittoni R, Bisogno S, Catenaccio M, Marcolongo R, Galeazzi M, Laghi-Pasini F. Homocysteine enhances cytokine production in cultured synoviocytes from rheumatoid arthritis patients. Clin. Exp. Rheumatol. 24: 387-393 (2006).

• Leclerc D, Rozen R. Molecular genetics of MTHFR: polymorphisms are not all benign. Med. Sci. (Paris) 23: 297-302 (2007).

• Lee SA. Gene-diet interaction on cancer risk in epidemiological studies. J. Prev. Med. Public Health 42: 360-370 (2009). *

• Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin. Exp. Res. 28: 173-181 (2004).

• Legendre C, Causse E, Chaput E, Salvayre R, Pineau T, Edgar AD. Fenofibrate induces a selective increase of protein-bound homocysteine in rodents: a PPARalpha-mediated effect. Biochem. Biophys. Res. Commun. 295: 1052-1056 (2002). *

• Lentz SR, Haynes WG. Homocysteine: is it a clinically important cardiovascular risk factor? Cleve. Clin. J. Med. 71: 729-734 (2004). *

• Lever M, George PM, Slow S, Elmslie JL, Scott RS, Richards AM, Fink JN, Chambers ST. Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovasc. Drugs Ther. 23: 395-401 (2009).

• Li D, Mann NJ, Sinclair AJ. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids 41: 85-89 (2006).

• Li D, Yu XM, Xie HB, Zhang YH, Wang Q, Zhou XQ, Yu P, Wang LJ. Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients. Prostaglandins Leukot. Essent. Fatty Acids 76: 293-297 (2007). *

• Li F, Watkins D, Rosenblatt DS. Vitamin B(12) and birth defects. Mol. Genet. Metab. 98: 166-172 (2009). *

• Li L, Gao PJ, Xi R, Wu CF, Zhu DL, Yan J, Lu GP. Pioglitazone inhibits homocysteine-induced migration of vascular smooth musclecells through a peroxisome proliferator-activated receptor gamma-independentmechanism. Clin. Exp. Pharmacol. Physiol. 35: 1471-1476 (2008). *

• Li L, Xie J, Zhang M, Wang S. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes. Acta Biochim. Biophys. Sin. (Shanghai) 41: 464-471 (2009).

• Li Y, Chen J, Liu J, Yang X, Wang K. Binding of Cu2+ to S-adenosyl-L-homocysteine hydrolase. J. Inorg. Biochem. 98: 977-983 (2004). *

• Lim U, Peng K, Shane B, Stover PJ, Litonjua AA, Weiss ST, Gaziano JM, Strawderman RL, Raiszadeh F, Selhub J, Tucker KL, Cassano PA. Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J. Nutr. 135: 1989-1994 (2005). *

• Lin PT, Cheng CH, Wei JC, Huang YC. Low plasma pyridoxal 5'-phosphate concentration and MTHFR 677C-->T genotypes are associated with increased risk of hypertension. Int. J. Vitam. Nutr. Res. 78: 33-40 (2008).

• Lin PT, Huang MC, Lee BJ, Cheng CH, Tsai TP, Huang YC. High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetra-hydrofolate reductase 677C-->T genotypes. Asia Pac. J. Clin. Nutr. 17: 330-338 (2008).

• Lin YH, Pao KY, Wu VC, Lin YL, Chien YF, Hung CS, Chen YJ, Liu CP, Tsai IJ, Gau CS, Wu KD, Hwang JJ. The influence of estimated creatinine clearance on plasma homocysteine in hypertensive patients with normal serum creatinine. Clin. Biochem. 40: 230-234 (2007). *

• Liu CC, Ho WY, Leu KL, Tsai HM, Yang TH. Effects of S-adenosylhomocysteine and homocysteine on DNA damage and cell cytotoxicity in murine hepatic and microglia cell lines. J. Biochem. Mol. Toxicol. 23: 349-356 (2009). *

• Liu R, Wang JZ. Protein phosphatase 2A in Alzheimer's disease. Pathophysiology 16: 273-277 (2009).

• Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Hwang SF, Chen YM. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 46: 1413-1425 (2007). *

• Lobrano A, Blanchard K, Rock W, Johnson W, Schmieg B, Borman K, Araghizadeh F, Minocha A, Abell TL. Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis. Adv. Ther. 23: 750-768 (2006).

• Loehrer FM, Schwab R, Angst CP, Haefeli WE, Fowler B. Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. J. Pharmacol. Exp. Ther. 282: 845-850 (1997). *

• Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr; Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N. Engl. J. Med. 354: 1567-1577 (2006). *

• Look MP, Riezler R, Reichel C, Brensing KA, Rockstroh JK, Stabler SP, Spengler U, Berthold HK, Sauerbruch T. Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Scand. J. Gastroenterol. 35: 866-872 (2000). *

• Lopez-Olivo MA, Gonzalez-Lopez L, Garcia-Gonzalez A, Villa-Manzano AI, Cota-Sanchez AR, Salazar-Paramo M, Varon-Villalpando E, Cardona-Munoz EG, Gamez-Nava JI. Factors associated with hyperhomocysteinaemia in Mexican patients with rheumatoid arthritis. Scand. J. Rheumatol. 35: 112-116 (2006). *

• Lopez-Sanchez LM, Corrales FJ, Barcos M, Espejo I, Munoz-Castaneda JR, Rodriguez-Ariza A. Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis. Lab. Invest. Oct 5 [Epub ahead of print] (2009). *

• Lopreato FR, Stabler SP, Carvalho FR, Hirata RD, Hirata MH, Robi DL, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM. Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates. Clin. Chim. Acta 398: 134-139 (2008). *

• Loscalzo J. Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology. J. Clin. Invest. 119: 3203-3205 (2009). *

• Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc. Natl. Acad. Sci. U.S.A. 98: 5560-5565 (2001). *

• Luc G, Jacob N, Bouly M, Fruchart JC, Staels B, Giral P. Fenofibrate increases homocystinemia through a PPARalpha-mediated mechanism. J. Cardiovasc. Pharmacol. 43: 452-453 (2004).

• Luka Z. Chapter 11. Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase. Vitam. Horm. 79: 325-345 (2008).

• Luka Z, Capdevila A, Mato JM, Wagner C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 15: 393-397 (2006). *

• Luka Z, Cerone R, Phillips JA 3rd, Mudd HS, Wagner C. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum. Genet. 110: 68-74 (2002). *

• Luka Z, Pakhomova S, Loukachevitch L, Egli M, Newcomer ME, Wagner C. 5-Methyltetrahydrofolate is bound in intersubunit areas of rat liver folate binding protein, glycine N-methyltransferase. J. Biol. Chem. 282: 4069-4075 (2007). *

• Lundberg GD. Homocysteine-lowering B vitamins do not lower mortality or cardiovascular events. Medscape J. Med. 10: 273 (2008). *

• Luo D, Yan S, Cheng X, Song Y. Levels of homocysteine and polymorphisms of homocysteine metabolism-related enzymes in patients with type 2 diabetes mellitus and coronary heart disease. Wei Sheng Yan Jiu 38: 39-42 (2009).

• Lutz UC, Batra A, Kolb W, Machicao F, Maurer S, Kohnke MD. Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure. Alcohol Clin. Exp. Res. 30: 1966-1971 (2006). *

• Lv S, Fan R, Du Y, Hou M, Tang Z, Ling W, Zhu H. Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice. Eur. J. Nutr. 48: 205-212 (2009).

• Ma DW, Finnell RH, Davidson LA, Callaway ES, Spiegelstein O, Piedrahita JA, Salbaum JM, Kappen C, Weeks BR, James J, Bozinov D, Lupton JR, Chapkin RS. Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Res. 65: 887-897 (2005). *

• Macfarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J. Biol. Chem. 283: 25846-25853 (2008). *

• Macfarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J. Biol. Chem. 284: 1533-1539 (2009). *

• Maeda M, Fujio Y, Azuma J. MTHFR gene polymorphism and diabetic retinopathy. Curr. Diabetes Rev. 2: 467-476 (2006).

• Magis D, Allena M, Coppola G, Di Clemente L, Gerard P, Schoenen J. Search for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials. Cephalalgia 27: 1142-1149 (2007).

• Mahmood A, Needham J, Prosser J, Mainwaring J, Trebble T, Mahy G, Ramage J. Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease. Eur. J. Gastroenterol. Hepatol. 17: 739-744 (2005).

• Mahmud N, Molloy A, McPartlin J, Corbally R, Whitehead AS, Scott JM, Weir DG. Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications. Gut 45: 389-394 (1999). *

• Maire F, Beaugerie L, Cohen M, Deschamps A, Cosnes J, Capeau J, Gendre JP. Factors associated with hyperhomocysteinemia in Crohn's disease. Gastroenterol. Clin. Biol. 25: 745-748 (2001).

• Maksimowicz-McKinnon K, Magder LS, Petri M. Predictors of carotid atherosclerosis in systemic lupus erythematosus. J. Rheumatol. 33: 2458-2463 (2006).

• Malanovic N, Streith I, Wolinski H, Rechberger G, Kohlwein SD, Tehlivets O. S-Adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. J. Biol. Chem. 283: 23989-23999 (2008). *

• Malerba M, Gisondi P, Radaeli A, Sala R, Calzavara Pinton PG, Girolomoni G. Plasma homocysteine and folate levels in patients with chronic plaque psoriasis. Br. J. Dermatol. 155: 1165-1169 (2006). *

• Malinowska A, Chmurzynska A. Polymorphism of genes encoding homocysteine metabolism-related enzymes and risk for cardiovascular disease. Nutr. Res. 29: 685-695 (2009). *

• Malouf M, Grimley EJ, Areosa SA. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst. Rev. 4: CD004514 (2003). *

• Manolakis A, Kapsoritakis AN, Potamianos SP. A review of the postulated mechanisms concerning the association of Helicobacter pylori with ischemic heart disease. Helicobacter 12: 287-297 (2007). *

• Mansoor A, Mazhar K, Ali L, Muazzam AG, Siddiqi S, Usman S. Prevalence of the C677T single-nucleotide polymorphism in the methylenetetrahydrofolate reductase gene among Pakistani ethnic groups. Genet. Test. Mol. Biomarkers 13: 521-526 (2009).

• Mao R, Fan Y, Chen F, Fu S. Genetic polymorphism of MTHFR G1793A in Chinese populations. Eur. J. Epidemiol. 23: 363-368 (2008).

• Mao R, Fan Y, Chen F, Sun D, Bai J, Fu S. Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations. Cell. Biochem. Funct. 26: 352-358 (2008). *

• Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu. Rev. Med. 60: 39-54 (2009). *

• Marouf R, Mojiminiyi O, Qurtom M, Abdella N, Al Wazzan H, Al Humood S, Al Mazeedy M. Plasma homocysteine and hematological factors in patients with venous thromboembolic diseases in Kuwait. Acta Haematol. 117: 98-105 (2006).

• Marti-Carvajal AJ, Sola I, Lathyris D, Salanti G. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst. Rev. 4: CD006612 (2009). *

• Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Panorganismal gut microbiome-host metabolic crosstalk. J. Proteome Res. 8: 2090-2105 (2009). *

• Martinez ME, Giovannucci E, Jiang R, Henning SM, Jacobs ET, Thompson P, Smith-Warner SA, Alberts DS. Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence. Int. J. Cancer 119: 1440-1446 (2006). *

• Martinez ME, Thompson P, Jacobs ET, Giovannucci E, Jiang R, Klimecki W, Alberts DS. Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway. Gastroenterology 131: 1706-1716 (2006). *

• Martinez-Berriotxoa A, Ruiz-Irastorza G, Egurbide Arberas MV, Rueda Gutierrez M, Aguirre Errasti C. Plasma homocysteine levels in systemic lupus erythematosus. Med. Clin. (Barc.) 120: 681-685 (2003).

• Martinez-Frias ML, Perez B, Desviat LR, Castro M, Leal F, Rodriguez L, Mansilla E, Martinez-Fernandez ML, Bermejo E, Rodriguez-Pinilla E, Prieto D, Ugarte M. Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? Am. J. Med. Genet. A. 140: 987-997 (2006).

• Mato JM, Lu SC. Homocysteine, the bad thiol. Hepatology 41: 976-979 (2005). *

• Matte C, Mackedanz V, Stefanello FM, Scherer EB, Andreazza AC, Zanotto C, Moro AM, Garcia SC, Goncalves CA, Erdtmann B, Salvador M, Wyse AT. Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: protective effect of folic acid. Neurochem. Int. 54: 7-13 (2009).

• Matthews RG, Elmore CL. Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias. Clin. Chem. Lab. Med. 45: 1700-1703 (2007). *

• Matthews RG, Koutmos M, Datta S. Cobalamin-dependent and cobamide-dependent methyltransferases. Curr. Opin. Struct. Biol. 18: 658-666 (2008). *

• Matthews RP, Lorent K, Mañoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M. TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development 136: 865-875 (2009). *

• Matuszek MA, Boutcher SH. Elevated levels of circulating cortisol in young normotensive adult men with a family history of hypertension. Clin. Exp. Pharmacol. Physiol. 35: 280-286 (2008).

• Mayer Jr O, Simon J, Holubec L, Pikner R, Trefil L. Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and endothelial dysfunction surrogates. Physiol. Res. 55: 475-481 (2006). *

• Mayer O Jr, Simon J, Holubec L, Pikner R, Vobrubova I, Trefil L. Fibrate treatment and prevalence risk of mild hyperhomocysteinaemia in clinical coronary heart disease patients. Eur. J. Cardiovasc. Prev. Rehabil. 11: 244-249 (2004).

• Mazza A, Bossone E, Mazza F, Distante A. Reduced serum homocysteine levels in type 2 diabetes. Nutr. Metab. Cardiovasc. Dis. 15: 118-124 (2005).

• McGimpsey SJ, Woodside JV, Cardwell C, Cahill M, Chakravarthy U. Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis. Ophthalmology 116: 1778-1787.e1 (2009).

• McLaughlin M, Alloza I, Pham Quoc H, Scott CJ, Hirabayashi Y, Vandenbroeck K. Inhibition of secretion of interleukin-12 (IL-12) /IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP. J. Biol. Chem. Jan 6 [Epub ahead of print] (2010). *

• McLean E, de Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr. Bull. 29: S38-S51 (2008).

• McMullen MH, Rowling MJ, Ozias MK, Schalinske KL. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. Arch. Biochem. Biophys. 401: 73-80 (2002). *

• Mead A, Atkinson G, Albin D, Alphey D, Baic S, Boyd O, Cadigan L, Clutton L, Craig L, Flanagan C, Greene P, Griffiths E, Lee NJ, Li M, McKechnie L, Ottaway J, Paterson K, Perrin L, Rigby P, Stone D, Vine R, Whitehead J, Wray L, Hooper L, et al. Dietetic guidelines on food and nutrition in the secondary prevention of cardiovascular disease - evidence from systematic reviews of randomized controlled trials (second update, January 2006). J. Hum. Nutr. Diet. 19: 401-419 (2006). *

• Midttun O, Hustad S, Ueland PM. Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 23: 1371-1379 (2009). *

• Mikael LG, Genest J Jr, Rozen R. Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circ. Res. 98: 564-571 (2006). *

• Milani RV, Lavie CJ. Homocysteine: the Rubik's cube of cardiovascular risk factors. Mayo Clin. Proc. 83: 1200-1202 (2008). *

• Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern. Med. Rev. 13: 216-226 (2008).

• Moat SJ. Plasma total homocysteine: instigator or indicator of cardiovascular disease? Ann. Clin. Biochem. 45: 345-348 (2008).

• Morgenstern I, Raijmakers MT, Peters WH, Hoensch H, Kirch W. Homocysteine, cysteine, and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease. Dig. Dis. Sci. 48: 2083-2090 (2003). *

• Morita DC, Donaldson A, Butterfield RJ, Benedict SL, Bale JF Jr. Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke. Pediatr. Neurol. 41: 247-249 (2009).

• Mouelhi L, Mekki H, Debbeche R, Salem M, Najjar T. Thrombosis in inflammatory bowel disease: mechanisms and risk factors. Tunis. Med. 87: 307-310 (2009).

• Mtiraoui N, Zammiti W, Ghazouani L, Braham NJ, Saidi S, Finan RR, Almawi WY, Mahjoub T. Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses. Reproduction 131: 395-401 (2006). *

• Muniz MT, Siqueira ER, Fonseca RA, D Almeida V, Hotta JK, Santos JE, Cavalcanti MD, Sampaio CA. Evaluation of MTHFR C677T gene polymorphism and homocysteine level in coronary atherosclerotic disease. Arq. Bras. Endocrinol. Metabol. 50: 1059-1065 (2006).

• Murawska-Cialowicz E, Januszewska L, Zuwala-Jagiello J, Milczarska J, Zawadzki M, Paprocka-Borowicz M, Wierzbicka-Damska I. Melatonin decreases homocysteine level in blood of rats. J. Physiol. Pharmacol. 59: 717-729 (2008). *

• Murr C, Meinitzer A, Grammer T, Schroecksnadel K, Bohm BO, Marz W, Fuchs D. Association between asymmetric dimethylarginine and neopterin in patients with and without angiographic coronary artery disease. Scand. J. Immunol. 70: 63-67 (2009). *

• Musarrat K, Kalathil D, Varughese GI. Metformin, B12 and homocysteine levels: the plausible cause or effect? J. Formos. Med. Assoc. 107: 505-506 (2008).

• Myers GL, Christenson RH, Cushman M, Ballantyne CM, Cooper GR, Pfeiffer C, Grundy SM, Labarthe DR, Levy D, Rifai N, Wilson PW. National Academy of Clinical Biochemistry Laboratory medicine practice guidelines: emerging biomarkers for primary prevention of cardiovascular disease. Clin. Chem. 55: 378-384 (2009). *

• Naess IA, Christiansen SC, Romundstad PR, Cannegieter SC, Blom HJ, Rosendaal FR, Hammerstrom J. Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population - results from the HUNT 2 study. Br. J. Haematol. 141: 529-535 (2008). *

• Nafar M, Khatami F, Kardavani B, Farjad R, Pour-Reza-Gholi F, Firouzan A, Kalantar A, Farhangi S, Einollahi B. Role of folic acid in atherosclerosis after kidney transplant: a double-blind, randomized, placebo-controlled clinical trial. Exp. Clin. Transplant. 7: 33-39 (2009).

• Nagaraja D, Noone ML, Bharatkumar VP, Christopher R. Homocysteine, folate and vitamin B(12) in puerperal cerebral venous thrombosis. J. Neurol. Sci. 272: 43-47 (2008).

• Nakano E, Taylor CJ, Chada L, McGaw J, Powers HJ. Hyperhomocystinemia in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 37: 586-590 (2003). *

• Namekata K, Enokido Y, Ishii I, Nagai Y, Harada T, Kimura H. Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. J. Biol. Chem. 279: 52961-52969 (2004). *

• Naushad S, Jamal MN, Angalena R, Prasad CK, Devi AR. Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians. Blood Coagul. Fibrinolysis 18: 113-117 (2007).

• Naushad SM, Jain Jamal MN, Prasad CK, Rama Devi AR. Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians. Clin. Chem. Lab. Med. 46: 73-79 (2008). *

• Newton BW, Russell WK, Russell DH, Ramaiah SK, Jayaraman A. Liver proteome analysis in a rodent model of alcoholic steatosis. J. Proteome Res. 8: 1663-1671 (2009).

• Newton BW, Russell WK, Russell DH, Ramaiah SK, Jayaraman A. Liver proteome analysis in a rodent model of alcoholic steatosis. J. Proteome Res. Feb 5 [Epub ahead of print] (2009). *

• Nielsen FH. Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats. J. Trace Elem. Med. Biol. 23: 204-213 (2009).

• Nieman KM, Hartz CS, Szegedi SS, Garrow TA, Sparks JD, Schalinske KL. Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am. J. Physiol. Endocrinol. Metab. 291: E1235-E1242 (2006). *

• Nieman KM, Rowling MJ, Garrow TA, Schalinske KL. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J. Biol. Chem. 279: 45708-45712 (2004). *

• Nijhout HF, Gregory JF, Fitzpatrick C, Cho E, Lamers KY, Ulrich CM, Reed MC. A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. J. Nutr. 139: 784-791 (2009). *

• Nilsson SE, Read S, Berg S, Johansson B. Heritabilities for fifteen routine biochemical values: findings in 215 Swedish twin pairs 82 years of age or older. Scand. J. Clin. Lab. Invest. 69: 562-569 (2009).

• No authors listed. Folic acid - monograph. Altern. Med. Rev. 10: 222-229 (2005). *

• No authors listed. 5-Methyltetrahydrofolate - monograph. Altern. Med. Rev. 11: 330-337 (2006). *

• No authors listed. Homocysteine: turns out not to B so simple. Harv. Health Lett. 31: 7 (2006).

• Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V, Belin N, Duchon A, Paul JL, Badel A, de Freminville B, Grattau Y, Blehaut H, Herault Y, Janel N, Delabar JM. DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One 4: e7540 (2009). *

• Ntaios G, Savopoulos C, Hatzitolios A. Lowering homocysteine with B vitamins in patients with coronary artery disease. JAMA 300: 2852-2853 (2008). *

• Nucera C, Vaccaro M, Moleti M, Priolo C, Tortorella G, Angioni A, Ientile R, Violi MA, Loda M, Trimarchi F, Vermiglio F. Antiphospholipid antibodies syndrome (APS) associated with hyperhomocysteinemia related to MTHFR gene C677T and A1298C heterozygous mutations in a young man with idiopathic hypoparathyroidism (DiGeorge syndrome). J. Clin. Endocrinol. Metab. 91: 2021-2026 (2006). *

• Nurk E, Tell GS, Refsum H, Ueland PM, Vollset SE. Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study. QJM 99: 289-298 (2006). *

• O'Leary VB, Parle-McDermott A, Molloy AM, Kirke PN, Johnson Z, Conley M, Scott JM, Mills JL. MTRR and MTHFR polymorphism: link to Down syndrome? Am. J. Med. Genet. 107: 151-155 (2002).

• Obeid R, Herrmann W. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. FEBS Lett. 583: 1215-1225 (2009). *

• Ohnami S, Sato Y, Yoshimura K, Ohnami S, Sakamoto H, Aoki K, Ueno H, Ikeda M, Morizane C, Shimada K, Sakamoto Y, Esaki M, Saito I, Hirose H, Saito D, Sugimura H, Kosuge T, Okusaka T, Yoshida T. His595Tyr polymorphism in the methionine synthase reductase gene is associated with pancreatic cancer risk. Gastroenterology 135: 477-488.e3 (2008). *

• Okka M, Ozturk M, Kockar MC, Bavbek N, Rasier Y, Gunduz K. Plasma homocysteine level and uveitis in Behcet's disease. Isr. Med. Assoc. J. 4: S931-S934 (2002). *

• Olas B, Kedzierska M, Wachowicz B. Comparative studies on homocysteine and its metabolite-homocysteine thiolactone action in blood platelets in vitro. Platelets 19: 520-527 (2008).

• Oldenburg B, Fijnheer R, van der Griend R, vanBerge-Henegouwen GP, Koningsberger JC. Homocysteine in inflammatory bowel disease: a risk factor for thromboembolic complications? Am. J. Gastroenterol. 95: 2825-2830 (2000). *

• Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP. Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig. Dis. Sci. 50: 235-240 (2005). *

• Oltean S, Banerjee R. Nutritional modulation of gene expression and homocysteine utilization by vitamin B12. J. Biol. Chem. 278: 20778-29784 (2003). *

• Oltean S, Banerjee R. A B12-responsive internal ribosome entry site (IRES) element in human methionine synthase. J. Biol. Chem. 280: 32662-32668 (2005). *

• Olthof MR, Brink EJ, Katan MB, Verhoef P. Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. Am. J. Clin. Nutr. 82: 111-117 (2005). *

• Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr. Drug Metab. 6: 15-22 (2005). *

• Ongphiphadhanakul B. Osteoporosis: the role of genetics and the environment. Forum Nutr. 60: 158-167 (2007).

• Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibutani S, Yokoyama H, Konta Y, Magota K, Okumura K. Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine. Ann. Med. 42: 79-86 (2010).

• Oterino A, Toriello M, Valle N, Castillo J, Alonso-Arranz A, Bravo Y, Ruiz-Alegria C, Quintela E, Pascual J. The relationship between homocysteine and genes of folate-related enzymes in migraine patients. Headache Jul 8 [Epub ahead of print] (2009).

• Ou X, Yang H, Ramani K, Iglesias Ara A, Chen H, Mato JM, Lu SC. Inhibition of human betaine homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. Biochem. J. 401: 87-96 (2007). *

• Oyama K, Sugimura Y, Murase T, Uchida A, Hayasaka S, Oiso Y, Murata Y. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr. J. 56: 29-37 (2009). *

• Ozaki SI, Inada A, Sada K. Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations. Biosci. Biotechnol. Biochem. 72: 2318-2323 (2008). *

• Ozarda Y, Sucu DK, Hizli B, Aslan D. Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell. Biochem. Funct. 27: 568-577 (2009). *

• Ozias MK, Schalinske KL. All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats. J. Nutr. 133: 4090-4094 (2003). *

• Ozkul Y, Evereklioglu C, Borlu M, Taheri S, Calis M, Dundar M, Ilhan O. 5,10-Methylenetetrahydrofolate reductase C677T gene polymorphism in Behcet's patients with or without ocular involvement. Br. J. Ophthalmol. 89: 1634-1637 (2005). *

• Pajares MA, Perez-Sala D. Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? Cell. Mol. Life Sci. 63: 2792-2803 (2006). *

• Pallinti V, Ganesan N, Anbazhagan M, Rajasekhar G. Serum biochemical markers in rheumatoid arthritis. Indian J. Biochem. Biophys. 46: 342-344 (2009).

• Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Di Palo A, Imbimbo BP, Vendemiale G, Capurso A, Solfrizzi V. Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review. ScientificWorldJournal 9: 373-389 (2009).

• Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, Capurso A, Solfrizzi V. Possible role of S-adenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease. J. Alzheimers Dis. 16: 467-470 (2009).

• Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I, Bonizzi M, Guidi L, De Vitis I, Santoliquido A, Fedeli G, Gasbarrini G, Gasbarrini A. Early atherosclerosis in patients with inflammatory bowel disease. Eur. Rev. Med. Pharmacol. Sci. 10: 7-11 (2006).

• Papa A, De Stefano V, Danese S, Chiusolo P, Persichilli S, Casorelli I, Zappacosta B, Giardina B, Gasbarrini A, Leone G, Gasbarrini G. Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease. Am. J. Gastroenterol. 96: 2677-2682 (2001). *

• Papa A, Santoliquido A, Danese S, Covino M, Campli CD, Urgesi R, Grillo A, Guglielmo S, Tondi P, Guidi L, Vitis ID, Fedeli G, Gasbarrini G, Gasbarrini A. Increased carotid intima-media thickness in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. 22: 839-846 (2005). *

• Papoutsakis C, Manios Y, Magkos F, Papaconstantinou E, Schulpis KH, Zampelas A, Matalas AL, Yiannakouris N. Effect of the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods. Nutrition Jan 22 [Epub ahead of print] (2010). *

• Papoutsakis C, Yiannakouris N, Manios Y, Papaconstantinou E, Magkos F, Schulpis KH, Zampelas A, Matalas AL. The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender. Eur. J. Clin. Nutr. 60: 155-162 (2006).

• Park CM, Cho CW, Rosenfeld ME, Song YS. Methionine supplementation accelerates oxidative stress and nuclear factor kappaB activation in livers of C57BL/6 mice. J. Med. Food 11: 667-674 (2008).

• Pasca SP, Dronca E, Kaucsar T, Craciun EC, Endreffy E, Ferencz BK, Iftene F, Benga I, Cornean R, Banerjee R, Dronca M. One carbon metabolism disturbances and the C667T MTHFR gene polymorphism in children with autism spectrum disorders. J. Cell. Mol. Med. Aug 9 [Epub ahead of print] (2009). *

• Pascale RM, Simile MM, De Miglio MR, Feo F. Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine. Alcohol 27: 193-198 (2002). *

• Pascale RM, Simile MM, Feo F. Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. Anticancer Res. 13: 1341-1356 (1993).

• Paterson E, Gordon MH, Niwat C, George TW, Parr L, Waroonphan S, Lovegrove JA. Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentrations but does not alter markers of oxidative stress or cardiovascular risk factors. J. Nutr. 136: 2849-2855 (2006). *

• Pattanayek R, Newcomer ME, Wagner C. Crystal structure of apo-glycine N-methyltransferase (GNMT). Protein Sci. 7: 1326-1331 (1998). *

• Pavarino-Bertelli EC, Sanches de Alvarenga MP, Goloni-Bertollo EM, Baptista MA, Haddad R, Hoerh NF, Eberlin MN, Abbud-Filho M. Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients. Transplant. Proc. 36: 2979-2981 (2004). *

• Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML. Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation. Biochemistry 45: 4808-4818 (2006). *

• Pejnovic N, Vratimos A, Lee SH, Popadic D, Takeda K, Akira S, Chan WL. Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet. Mol. Immunol. 47: 37-45 (2009). *

• Peralta AR, Canhao P. Hypothyroidism and cerebral vein thrombosis - a possible association. J. Neurol. 255: 962-966 (2008).

• Persa C, Pierce A, Ma Z, Kabil O, Lou MF. The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system. Exp. Eye Res. 79: 875-886 (2004).

• Petramala L, Acca M, Francucci CM, D'Erasmo E. Hyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases? J. Endocrinol. Invest. 32: S10-S14 (2009).

• Pexa A, Herrmann M, Taban-Shomal O, Henle T, Deussen A. Experimental hyperhomocysteinemia: differences of tissue metabolites between homocystine and methionine feeding in a rat model. Acta Physiol. (Oxf.) 197: 27-34 (2009). *

• Peyrin-Biroulet L, Gueant-Rodriguez RM, Chen M, Bronowicki JP, Bigard MA, Gueant JL. Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease. Am. J. Gastroenterol. 103: 399-406 (2008). *

• Peyrin-Biroulet L, Rodriguez-Gueant RM, Chamaillard M, Desreumaux P, Xia B, Bronowicki JP, Bigard MA, Gueant JL. Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine. Am. J. Gastroenterol. 102: 1108-1115 (2007). *

• Phelip JM, Ducros V, Faucheron JL, Flourie B, Roblin X. Association of hyperhomocysteinemia and folate deficiency with colon tumors in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 14: 242-248 (2008). *

• Phelip JM, Roblin X. Type 2 diabetes mellitus and colorectal cancer risk: is homocysteine the missing link? Am. J. Gastroenterol. 102: 466-467 (2007). *

• Pisciotta L, Cortese C, Gnasso A, Liberatoscioli L, Pastore A, Mannucci L, Irace C, Federici G, Bertolini S. Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia. Atherosclerosis 179: 333-338 (2005).

• Poduri A, Kaur J, Thakur JS, Kumari S, Jain S, Khullar M. Effect of ACE inhibitors and beta-blockers on homocysteine levels in essential hypertension. J. Hum. Hypertens. 22: 289-294 (2008).

• Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J. Hepatol. 51: 176-186 (2009).

• Polat M, Lenk N, Bingol S, Oztas P, Ilhan MN, Artuz F, Alli N. Plasma homocysteine level is elevated in patients on isotretinoin therapy for cystic acne: a prospective controlled study. J. Dermatolog. Treat. 19: 229-232 (2008). *

• Polyzos SA, Anastasilakis AD, Efstathiadou Z, Litsas I, Kita M, Panagiotou A, Papatheodorou A, Arsos G, Moralidis E, Barmpalios G, Zafeiriadou E, Triantafillidou E, Makrigiannaki E, Terpos E. Serum homocysteine, folate and vitamin B(12) in patients with Paget's disease of bone: the effect of zoledronic acid. J. Bone Miner. Metab. Oct 21 [Epub ahead of print] (2009). *

• Pooya S, Jalali MD, Jazayery AD, Saedisomeolia A, Eshraghian MR, Toorang F. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr. Metab. Cardiovasc. Dis. Jun 18 [Epub ahead of print] (2009).

• Postea O, Koenen RR, Hristov M, Weber C, Ludwig A. Homocysteine upregulates vascular transmembrane chemokine CXCL16 and induces CXCR6(+) lymphocyte recruitment in vitro and in vivo. J. Cell. Mol. Med. 12: 1700-1709 (2008). *

• Potaczek DP, Undas A, Celinska-Lowenhoff M, Szczeklik A. The I allele of the angiotensin-converting enzyme gene polymorphism may determine an increase in homocysteine levels in fibrate-treated subjects. Cardiovasc. Drugs Ther. 20: 229-232 (2006). *

• Potter K, Hankey GJ, Green DJ, Eikelboom J, Jamrozik K, Arnolda LF. The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis. BMC Cardiovasc. Disord. 8: 24 (2008). *

• Powers HJ. Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. J. Nutr. 135: 2960S-2966S (2005). *

• Primignani M, Martinelli I, Bucciarelli P, Battaglioli T, Reati R, Fabris F, Dell'era A, Pappalardo E, Mannucci PM. Risk factors for thrombophilia in extrahepatic portal vein obstruction. Hepatology 41: 603-608 (2005). *

• Prinz-Langenohl R, Fohr I, Pietrzik K. Beneficial role for folate in the prevention of colorectal and breast cancer. Eur. J. Nutr. 40: 98-105 (2001). *

• Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R. S-Adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc. Natl. Acad. Sci. U.S.A. 103: 6489-6494 (2006). *

• Prudova A, Martinov MV, Vitvitsky VM, Ataullakhanov FI, Banerjee R. Analysis of pathological defects in methionine metabolism using a simple mathematical model. Biochim. Biophys. Acta 1741: 331-338 (2005). *

• Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S, Emery PW, Sanders TA. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 54: 648-653 (2005). *

• Pufulete M, Al-Ghnaniem R, Leather AJ, Appleby P, Gout S, Terry C, Emery PW, Sanders TA. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124: 1240-1248 (2003). *

• Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am. J. Clin. Nutr. 86: 14-24 (2007). *

• Qian X, Lu Z, Tan M, Liu H, Lu D. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur. J. Hum. Genet. 15: 1239-1245 (2007). *

• Qin S, Ni M, De Vries GW. Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells. Invest. Ophthalmol. Vis. Sci. 49: 1274-1281 (2008). *

• Quash G, Fournet G. Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells. Curr. Med. Chem. 16: 3686-3700 (2009).

• Racine A, Nahon S, Jouannaud V, Caugant H, Lesgourgues B. Portal vein thrombosis in a patient with quiescent Crohn's disease associated with hyperhomocysteinemia and antiphospholipid antibody syndrome 1-yr after an ileocecal resection. Am. J. Gastroenterol. 103: 499-501 (2008). *

• Rahman SH, Srinivasan AR, Nicolaou A. Transsulfuration pathway defects and increased glutathione degradation in severe acute pancreatitis. Dig. Dis. Sci. 54: 675-682 (2009). *

• Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Hepatology Oct 27 [Epub ahead of print] (2009). *

• Ramsaransing GS, Fokkema MR, Teelken A, Arutjunyan AV, Koch M, De Keyser J. Plasma homocysteine levels in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 77: 189-192 (2006). *

• Rassoul F, Richter V, Hentschel B, Geisel J, Herrmann W, Kuntze T. Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity. Indian J. Med. Res. 127: 154-158 (2008). *

• Ratnam S, Wijekoon EP, Hall BN, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am. J. Physiol. Endocrinol. Metab. 290: E933-E939 (2006). *

• Ravaglia G, Paola F, Maioli F, Martelli M, Montesi F, Bastagli L, Bianchin M, Chiappelli M, Tumini E, Bolondi L, Licastro F. Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study. Exp. Gerontol. 41: 85-92 (2006).

• Ray JG. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch. Intern. Med. 158: 2101-2106 (1998). *

• Real JT, Martinez-Hervas S, Garcia-Garcia AB, Chaves FJ, Civera M, Ascaso JF, Carmena R. Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia. J. Atheroscler. Thromb. Jan 9 [Epub ahead of print] (2010).

• Redeen S, Ryberg A, Petersson F, Eriksson O, Nagga K, Borch K. Homocysteine levels in chronic gastritis and other conditions: relations to incident cardiovascular disease and dementia. Dig. Dis. Sci. Mar 7 [Epub ahead of print] (2009). *

• Reed MC, Nijhout HF, Neuhouser ML, Gregory JF 3rd, Shane B, James SJ, Boynton A, Ulrich CM. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J. Nutr. 136: 2653-2661 (2006). *

• Reed MC, Nijhout HF, Sparks R, Ulrich CM. A mathematical model of the methionine cycle. J. Theor. Biol. 226: 33-43 (2004). *

• Religa D, Czyzewski K, Styczynska M, Peplonska B, Lokk J, Chodakowska-Zebrowska M, Stepien K, Winblad B, Barcikowska M. Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease. Neurosci. Lett. 404: 56-60 (2006). *

• Remkova A. Diagnostic approach to hypercoagulable states. Bratisl. Lek. Listy. 107: 292-295 (2006).

• Reynolds HR, Buyon J, Kim M, Rivera T, Izmirly P, Tunick P, Clancy RM. Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus. Atherosclerosis Dec 16 [Epub ahead of print] (2009).

• Rho YH, Oeser A, Chung CP, Milne GL, Stein CM. Drugs used in the treatment of rheumatoid arthritis: relationship between current use and cardiovascular risk factors. Arch. Drug. Inf. 2: 34-40 (2009).

• Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 95: 1777-1782 (1997). *

• Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis 204: 412-417 (2009).

• Righetti M. Protective effect of vitamin B therapy on bone and cardiovascular disease. Recent Patents Cardiovasc. Drug Discov. 4: 37-44 (2009).

• Robert K, Nehme J, Bourdon E, Pivert G, Friguet B, Delcayre C, Delabar JM, Janel N. Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 128: 1405-1415 (2005). *

• Roblin X, Germain E, Phelip JM, Ducros V, Pofelski J, Heluwaert F, Oltean P, Faucheron JL, Bonaz B. Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients. Rev. Med. Interne. 27: 106-110 (2006).

• Roblin X, Phelip JM, Genevois M, Ducros V, Bonaz B. Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease. Aliment. Pharmacol. Ther. 25: 797-804 (2007). *

• Rodionov RN, Lentz SR. Many potential explanations for the homocysteine paradox. Arterioscler. Thromb. Vasc. Biol. 28: e161 (2008).

• Rodriguez C, Alcudia JF, Martínez-Gonzalez J, Raposo B, Navarro MA, Badimon L. Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction. Atherosclerosis 196: 558-564 (2008).

• Rodriguez WE, Sen U, Tyagi N, Kumar M, Carneal G, Aggrawal D, Newsome J, Tyagi SC. PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice. Int. J. Biol. Sci. 4: 236-244 (2008). *

• Romagnuolo J, Fedorak RN, Dias VC, Bamforth F, Teltscher M. Hyperhomocysteinemia and inflammatory bowel disease: prevalence and predictors in a cross-sectional study. Am. J. Gastroenterol. 96: 2143-2149 (2001). *

• Rose RF, Batchelor RJ, Turner D, Goulden V. Narrowband ultraviolet B phototherapy does not influence serum and red cell folate levels in patients with psoriasis. J. Am. Acad. Dermatol. 61: 259-262 (2009).

• Rossi GP, Seccia TM, Pessina AC. Lowering homocysteine with B vitamins in patients with coronary artery disease. JAMA 300: 2852 (2008).

• Rossi R, Giustarini D, Milzani A, Dalle-Donne I. Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy humans. J. Cell. Mol. Med. Jun 28 [Epub ahead of print] (2008). *

• Rowling MJ, McMullen MH, Chipman DC, Schalinske KL. Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J. Nutr. 132: 2545-2550 (2002). *

• Rowling MJ, McMullen MH, Schalinske KL. Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. J. Nutr. 132: 365-369 (2002). *

• Rowling MJ, Schalinske KL. Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells. J. Nutr. 133: 3392-3398 (2003). *

• Rowling MJ, Schalinske KL. Retinoid compounds activate and induce hepatic glycine N-methyltransferase in rats. J. Nutr. 131: 1914-1917 (2001). *

• Rua-Figueroa I, Arencibia-Mireles O, Elvira M, Erausquin C, Ojeda S, Francisco F, Naranjo A, Rodriguez-Gallego C, Garcia-Laorden I, Rodriguez-Perez J, Rodriguez-Lozano C. The factors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: a two year longitudinal study. Ann. Rheum. Dis. Aug 16 [Epub ahead of print] (2009).

• Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B. Safety issues and prospects for future generations of PPAR modulators. Biochim. Biophys. Acta 1771: 1065-1081 (2007). *

• Ruiz JR, Sola R, Gonzalez-Gross M, Ortega FB, Vicente-Rodriguez G, Garcia-Fuentes M, Gutierrez A, Sjostrom M, Pietrzik K, Castillo MJ. Cardiovascular fitness is negatively associated with homocysteine levels in female adolescents. Arch. Pediatr. Adolesc. Med. 161: 166-171 (2007).

• Rummel T, Suormala T, Haberle J, Koch HG, Berning C, Perrett D, Fowler B. Intermediate hyperhomocysteinaemia and compound heterozygosity for the common variant c.677C>T and a MTHFR gene mutation. J. Inherit. Metab. Dis. 30: 401 (2007). *

• Russo GT, Di Benedetto A, Alessi E, Ientile R, Antico A, Nicocia G, La Scala R, Di Cesare E, Raimondo G, Cucinotta D. Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in type 2 diabetes. J. Endocrinol. Invest. 29: 201-207 (2006).

• Russo GT, Di Benedetto A, Magazzu D, Giandalia A, Giorda CB, Ientile R, Previti M, Di Cesare E, Cucinotta D. Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study. Acta Diabetol. Nov 25 [Epub ahead of print] (2009).

• Rutsch F, Gailus S, Miousse IR, Suormala T, Sagne C, Toliat MR, Nurnberg G, Wittkampf T, Buers I, Sharifi A, Stucki M, Becker C, Baumgartner M, Robenek H, Marquardt T, Hohne W, Gasnier B, Rosenblatt DS, Fowler B, Nurnberg P. Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B(12) metabolism. Nat. Genet. 41: 234-239 (2009). *

• Ryan-Harshman M, Aldoori W. Vitamin B12 and health. Can. Fam. Physician 54: 536-541 (2008). *

• Sabbagh AS, Mahfoud Z, Taher A, Zaatari G, Daher R, Mahfouz RA. High prevalence of MTHFR gene A1298C polymorphism in Lebanon. Genet. Test. 12: 75-80 (2008).

• Sabio JM, Vargas-Hitos J, Zamora-Pasadas M, Mediavilla JD, Navarrete N, Ramirez A, Hidalgo-Tenorio C, Jaimez L, Martin J, Jimenez-Alonso J. Metabolic syndrome is associated with increased arterial stiffness and biomarkers of subclinical atherosclerosis in patients with systemic lupus erythematosus. J. Rheumatol. 36: 2204-2211 (2009).

• Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B(12) in patients with type 2 diabetes mellitus. J. Diabetes Complications 21: 118-123 (2007).

• Sahin S, Aksungar FB, Topkaya AE, Yildiz Z, Boru UT, Ayalp S, Karsidag S. Increased plasma homocysteine levels in multiple sclerosis. Mult. Scler. 13: 945-946 (2007). *

• Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, de Franchis R. Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am. J. Gastroenterol. 98: 112-117 (2003). *

• Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, Formenti S, De Franchis R, Vecchi M. Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics. Clin. Gastroenterol. Hepatol. 3: 574-580 (2005).

• Salerno-Kennedy R, Cashman KD. Relationship between dementia and nutrition-related factors and disorders: an overview. Int. J. Vitam. Nutr. Res. 75: 83-95 (2005).

• Salinas F M, Letelier S LM. Critically appraised article: effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease. A randomized control led trial. Rev. Med. Chil. 137: 982-985 (2009).

• Santini E, Madec S, Corretti V, Ferrannini E, Solini A. Effect of statins on soluble CD40 ligand in hypercholesterolemic type 2 diabetic patients. J. Endocrinol. Invest. 31: 660-665 (2008).

• Sarzi-Puttini P, Atzeni F, Shoenfeld Y, Ferraccioli G. TNF-alpha, rheumatoid arthritis, and heart failure: a rheumatological dilemma. Autoimmun. Rev. 4: 153-161 (2005).

• Sattar N, Crompton P, Cherry L, Kane D, Lowe G, McInnes IB. Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled study. Arthritis Rheum. 56: 831-839 (2007). *

• Savoia C, Ebrahimian T, Lemarie CA, Paradis P, Iglarz M, Amiri F, Javeshghani D, Schiffrin EL. Countervailing vascular effects of rosiglitazone in high cardiovascular risk mice: role of oxidative stress and PRMT-1. Clin. Sci. (Lond.) Dec 1 [Epub ahead of print] (2009). *

• Sazci A, Akpinar G, Aygun C, Ergul E, Senturk O, Hulagu S. Association of apolipoprotein E polymorphisms in patients with non-alcoholic steatohepatitis. Dig. Dis. Sci. 53: 3218-3224 (2008). *

• Sazci A, Ergul E, Aygun C, Akpinar G, Senturk O, Hulagu S. Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH). Cell. Biochem. Funct. 26: 291-296 (2008). *

• Scala I, Granese B, Sellitto M, Salome S, Sammartino A, Pepe A, Mastroiacovo P, Sebastio G, Andria G. Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring. Genet. Med. 8: 409-416 (2006).

• Scambi C, De Franceschi L, Guarini P, Poli F, Siciliano A, Pattini P, Biondani A, La Verde V, Bortolami O, Turrini F, Carta F, D'Orazio C, Assael BM, Faccini G, Bambara LM. Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial. PLoS ONE 4: e4782 (2009). *

• Scazzone C, Acuto S, Guglielmini E, Campisi G, Bono A. Methionine synthase reductase (MTRR) A66G polymorphism is not related with plasma homocysteine concentration and risk for vascular disease. Exp. Mol. Pathol. Feb 4 [Epub ahead of print] (2009). *

• Scazzone C, Acuto S, Guglielmini E, Campisi G, Bono A. Methionine synthase reductase (MTRR) A66G polymorphism is not related to plasma homocysteine concentration and the risk for vascular disease. Exp. Mol. Pathol. 86: 131-133 (2009).

• Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle DJ, Wilson PW, Wolf PA. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham heart study. Arch. Neurol. 63: 1545-1550 (2006). *

• Schalinske KL, Steele RD. 13-cis-Retinoic acid alters methionine metabolism in rats. J. Nutr. 121: 1714-1719 (1991). *

• Schmeling H, Biber D, Heins S, Horneff G. Influence of methylenetetrahydrofolate reductase polymorphisms on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis. J. Rheumatol. 32: 1832-1836 (2005).

• Schnackenbergs LK, Chen M, Sun J, Holland RD, Dragan Y, Tong W, Welsh W, Beger RD. Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies. Toxicol. Appl. Pharmacol. 235: 25-32 (2009). *

• Scholl J. Lowering homocysteine with B vitamins in patients with coronary artery disease. JAMA 300: 2853 (2008).

• Schwab U, Torronen A, Meririnne E, Saarinen M, Alfthan G, Aro A, Uusitupa M. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J. Nutr. 136: 34-38 (2006). *

• Schwahn BC, Laryea MD, Chen Z, Melnyk S, Pogribny I, Garrow T, James SJ, Rozen R. Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. Biochem. J. 382: 831-840 (2004). *

• Schwahn BC, Wendel U, Lussier-Cacan S, Mar MH, Zeisel SH, Leclerc D, Castro C, Garrow TA, Rozen R. Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism 53: 594-599 (2004). *

• Segal R, Baumoehl Y, Elkayam O, Levartovsky D, Litinsky I, Paran D, Wigler I, Habot B, Leibovitz A, Sela BA, Caspi D. Anemia, serum vitamin B12, and folic acid in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus. Rheumatol. Int. 24: 14-19 (2004). *

• Selhub J. Public health significance of elevated homocysteine. Food Nutr. Bull. 29: S116-S125 (2008).

• Selhub J. Homocysteine metabolism. Annu. Rev. Nutr. 19: 217-246 (1999). *

• Selhub J, Jacques PF, Dallal G, Choumenkovitch S, Rogers G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr. Bull. 29: S67-S73 (2008).

• Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc. Natl. Acad. Sci. U.S.A. 104: 19995-20000 (2007). *

• Selhub J, Morris MS, Jacques PF, Rosenberg IH. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am. J. Clin. Nutr. 89: 702S-706S (2009). *

• Selley ML. A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease. Neurobiol. Aging 28: 1834-1839 (2007).

• Semmler A, Linnebank M, Krex D, Gotz A, Moskau S, Ziegler A, Simon M. Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms. Cerebrovasc. Dis. 26: 425-429 (2008).

• Sen U, Rodriguez WE, Tyagi N, Kumar M, Kundu S, Tyagi SC. Ciglitazone, a PPARgamma agonist ameliorates diabetic nephropathy, in part, through homocysteine clearance. Am. J. Physiol. Endocrinol. Metab. 295: E1205-E1212 (2008). *

• Setoue M, Ohuchi S, Morita T, Sugiyama K. Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats. Biosci. Biotechnol. Biochem. 72: 1696-1703 (2008). *

• Severus WE, Littman AB, Stoll AL. Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder. Harv. Rev. Psychiatry 9: 280-293 (2001).

• Shaker OG, El-Tahlawi SM. Is there a relationship between homocysteine and vitiligo? A pilot study. Br. J. Dermatol. 159: 720-724 (2008). *

• Shargorodsky M, Boaz M, Pasternak S, Hanah R, Matas Z, Fux A, Beigel Y, Mashavi M. Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis? Diabetes Metab. Res. Rev. 25: 70-75 (2008).

• Sharma P, Kumar J, Garg G, Kumar A, Patowary A, Karthikeyan G, Ramakrishnan L, Brahmachari V, Sengupta S. Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol. 27: 357-365 (2008).

• Sharma P, Kumar S, Brahmachari V, Sundaramoorthy E, Mahajan A, Sharma A, Sengupta S. Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies. Lipids Health Dis. 5: 1 (2006). *

• Shay H, Frumento RJ, Bastien A. General anesthesia and methylenetetrahydrofolate reductase deficiency. J. Anesth. 21: 493-496 (2007).

• Shinohara M, Ji C, Kaplowitz N. Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology Oct 22 [Epub ahead of print] (2009). *

• Shiraki M, Urano T, Kuroda T, Saito M, Tanaka S, Miyao-Koshizuka M, Inoue S. The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures. J. Bone Miner. Metab. 26: 595-602 (2008). *

• Shu S, Mahadeo DC, Liu X, Liu W, Parent CA, Korn ED. S-Adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration. Proc. Natl. Acad. Sci. U.S.A. 103: 19788-19793 (2006). *

• Sibrian-Vazquez M, Escobedo JO, Lim S, Samoei GK, Strongin RM. Homocystamides promote free-radical and oxidative damage to proteins. Proc. Natl. Acad. Sci. U.S.A. 107: 551-554 (2010). *

• Signorello MG, Segantin A, Passalacqua M, Leoncini G. Homocysteine decreases platelet NO level via protein kinase C activation. Nitric Oxide 20: 104-113 (2009).

• Singh K, Agrawal NK, Khanna A, Jain M, Pandey S. Cystathionine B-synthase 844ins68 gene variant and idiopathic male infertility. Reprod. Sci. Aug 5 [Epub ahead of print] (2009).

• Sirachainan N, Tapanapruksakul P, Visudtibhan A, Chuansumrit A, Cheeramakara C, Atamasirikul K, Chotsuppakarn S, Areekul S. Homocysteine, MTHFR C677 T, vitamin B12, and folate levels in Thai children with ischemic stroke: a case-control study. J. Pediatr. Hematol. Oncol. 28: 803-808 (2006).

• Siuda J, Gorzkowska A, Patalong-Ogiewa M, Krzystanek E, Czech E, Wiechula B, Ganczorz W, Danch A, Jasinska-Myga B, Opala G. From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. Neurol. Neurochir. Pol. 43: 321-329 (2009).

• Slow S, Garrow TA. Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J. Nutr. 136: 2279-2283 (2006). *

• Smith AD. The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr. Bull. 29: S143-S172 (2008).

• Soliman EZ, Shalash OA. Homocysteine, vitamins, and vascular disease prevention: more negative results. Am. J. Clin. Nutr. 87: 1069-1070 (2008). *

• Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes mellitus in women: a randomized controlled trial. Diabetes 58: 1921-1928 (2009). *

• Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ. Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease. Hepatology 47: 867-879 (2008). *

• Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, Barve S, McClain CJ. S-Adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40: 989-997 (2004). *

• Sood HS, Hunt MJ, Tyagi SC. Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia. Am. J. Physiol. Lung Cell. Mol. Physiol. 284: L333-L341 (2003). *

• Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordonez-Llanos J, M Martin-Campos J, Lathrop M, Stone W, Blangero J, Fontcuberta J. A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am. J. Hum. Genet. 76: 925-933 (2005). *

• Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. Hepatic VLDL and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem. J. 395: 363-371 (2006). *

• Spence JD. Homocysteine and stroke prevention: have the trials settled the issue? Int. J. Stroke 1: 242-244 (2006).

• Spiroski I, Kedev S, Antov S, Arsov T, Krstevska M, Dzhekova-Stojkova S, Bosilkova G, Kostovska S, Trajkov D, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Spiroski M. Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis. Acta Biochim. Pol. 55: 587-594 (2008). *

• Spurgeon S, Yu M, Phillips JD, Epner EM. Cladribine: not just another purine analogue? Expert Opin. Investig. Drugs 18: 1169-1181 (2009).

• Stabler SP, Allen RH. Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin. Chem. 50: 365-372 (2004). *

• Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu. Rev. Nutr. 24: 299-326 (2004). *

• Stam F, Smulders YM, van Guldener C, Jakobs C, Stehouwer CD, de Meer K. Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects. Clin. Sci. (Lond.) 108: 449-456 (2005).

• Stam F, van Guldener C, ter Wee PM, Kulik W, Smith DE, Jakobs C, Stehouwer CD, de Meer K. Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine. Am. J. Physiol. Renal Physiol. 287: F215-F223 (2004). *

• Stanger O, Fowler B, Piertzik K, Huemer M, Haschke-Becher E, Semmler A, Lorenzl S, Linnebank M. Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Rev. Neurother. 9: 1393-1412 (2009).

• Stanislawska-Sachadyn A, Jensen LE, Kealey C, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. Association between the NAT1 1095C > A polymorphism and homocysteine concentration. Am. J. Med. Genet. A. 140: 2374-2377 (2006).

• Stanislawska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women. Ann. Hum. Genet. 73: 484-491 (2009). *

• Stankova J, Lawrance AK, Rozen R. Methylenetetrahydrofolate reductase (MTHFR): a novel target for cancer therapy. Curr. Pharm. Des. 14: 1143-1150 (2008).

• Stea TH, Mansoor MA, Wandel M, Uglem S, Frolich W. Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread. Eur. J. Nutr. 47: 201-209 (2008). *

• Stea TH, Uglem S, Wandel M, Mansoor MA, Frolich W. Association between folate intake from different food sources in Norway and homocysteine status in a dietary intervention among young male adults. Br. J. Nutr. 102: 899-906 (2009). *

• Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am. J. Clin. Nutr. 83: 5-10 (2006). *

• Steer C, Emmett P, Lewis S, Smith GD, Tobias J. The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in nine-year-old children. J. Bone Miner. Res. 24: 117-124 (2009).

• Steffen LM, Folsom AR, Cushman M, Jacobs DR Jr, Rosamond WD. Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism. The longitudinal investigation of thromboembolism etiology. Circulation 115: 188-195 (2007). *

• Stipanuk MH. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu. Rev. Nutr. 24: 539-577 (2004). *

• Stirban A. Drugs for the treatment of diabetes complications. Zycose: a new player in the field? Drugs Today (Barc.) 44: 783-796 (2008).

• Stover PJ. Physiology of folate and vitamin B12 in health and disease. Nutr. Rev. 62: S3-S12 (2004).

• Strain JJ, Dowey L, Ward M, Pentieva K, McNulty H. B-vitamins, homocysteine metabolism and CVD. Proc. Nutr. Soc. 63: 597-603 (2004). *

• Strauss E, Waliszewski K, Pawlak AL. The different genotypes of MTHFR 1298A>C and PON1 -108C>T polymorphisms confer the increased risk of the abdominal aortic aneurysm in the smoking and nonsmoking persons. Przegl. Lek. 62: 1023-1030 (2005).

• Struys EA, Jansen EE, de Meer K, Jakobs C. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin. Chem. 46: 1650-1656 (2000). *

• Sulikowska B, Czarny J, Rosc D, Odrowaz-Sypniewska G, Manitius J, Sliwka DM. Some metabolic and genetic risk factors and the progression of IgA nephropathy - preliminary report. Pol. Merkur. Lekarski. 21: 132-135 (2006).

• Summers CM, Cucchiara AJ, Nackos E, Hammons AL, Mohr E, Whitehead AS, Von Feldt JM. Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus. J. Rheumatol. 35: 2179-2186 (2008).

• Summers CM, Hammons AL, Mitchell LE, Woodside JV, Yarnell JW, Young IS, Evans A, Whitehead AS. Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations. Eur. J. Hum. Genet. 16: 1010-1013 (2008). *

• Sun J, Xu Y, Zhu Y, Lu H. Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in type 2 diabetes mellitus. J. Endocrinol. Invest. 29: 814-820 (2006).

• Sun JZ, Xu Y, Lu H, Zhu Y. Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes. Neurol. India 57: 589-593 (2009).

• Szamosi S, Csiki Z, Szomjak E, Szolnoki E, Szoke G, Szekanecz Z, Szegedi G, Shoenfeld Y, Szucs G. Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage? Clin. Rev. Allergy Immunol. 36: 145-149 (2009). *

• Szegedi SS, Castro CC, Koutmos M, Garrow TA. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J. Biol. Chem. 283: 8939-8945 (2008). *

• Szekanecz Z, Kerekes G, Der H, Sandor Z, Szabo Z, Vegvari A, Simkovics E, Soos L, Szentpetery A, Besenyei T, Szucs G, Szanto S, Tamasi L, Szegedi G, Shoenfeld Y, Soltesz P. Accelerated atherosclerosis in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 1108: 349-358 (2007). *

• Szvetko AL, Fowdar J, Nelson J, Colson N, Tajouri L, Csurhes PA, Pender MP, Griffiths LR. No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort. J. Neurol. Sci. 252: 49-52 (2007). *

• Taban-Shomal O, Kilter H, Wagner A, Schorr H, Umanskaya N, Hubner U, Bohm M, Herrmann W, Herrmann M. The cardiac effects of prolonged vitamin B(12) and folate deficiency in rats. Cardiovasc. Toxicol. 9: 95-102 (2009). *

• Tajouri L, Martin V, Gasparini C, Ovcaric M, Curtain R, Lea RA, Haupt LM, Csurhes P, Pender MP, Griffiths LR. Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis. Brain Res. Bull. 69: 327-331 (2006).

• Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F. Catalytic mechanism of glycine N-methyltransferase. Biochemistry 42: 8394-8402 (2003). *

• Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, Abecasis GR, Schlessinger D, Uda M, Ferrucci L. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am. J. Hum. Genet. 84: 477-482 (2009). *

• Tang B, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase. Nutrition Dec 24 [Epub ahead of print] (2009). *

• Tang C, Zhang Z, Xu B, Li M, Liu J, Cui J. Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro. Anticancer Drugs 19: 697-704 (2008).

• Tanghe KA, Garrow TA, Schalinske KL. Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats. J. Nutr. 134: 2913-2918 (2004). *

• Tao J, Yang M, Chen Z, Huang Y, Zhao Q, Xu J, Ren H, Zhao H, Chen Z, Ren Q, Yang R. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. J. Clin. Immunol. 28: 432-439 (2008). *

• Tavakkoly Bazzaz J, Shojapoor M, Nazem H, Amiri P, Fakhrzadeh H, Heshmat R, Parvizi M, Hasani Ranjbar S, Amoli MM. Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity. Mol. Biol. Rep. May 13 [Epub ahead of print] (2009). *

• Taysi S, Sari RA, Dursun H, Yilmaz A, Keles M, Cayir K, Akyuz M, Uyanik A, Guvenc A. Evaluation of nitric oxide synthase activity, nitric oxide, and homocysteine levels in patients with active Behcet's disease. Clin. Rheumatol. 27: 1529-1534 (2008). *

• Tchantchou F, Graves M, Falcone D, Shea TB. S-Adenosylmethionine mediates glutathione efficacy by increasing glutathione S-transferase activity: implications for S-adenosyl methionine as a neuroprotective dietary supplement. J. Alzheimers Dis. 14: 323-328 (2008).

• Tchantchou F, Shea TB. Chapter 3. Folate deprivation, the methionine cycle, and Alzheimer's disease. Vitam. Horm. 79: 83-97 (2008).

• Tehlivets O, Hasslacher M, Kohlwein SD. S-Adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. FEBS Lett. 577: 501-506 (2004). *

• Tennyson CA, Lewis SK, Green PH. Review: new and developing therapies for celiac disease. Ther. Adv. Gastroenterol. 2: 303-309 (2009). *

• Terra SG, Francone OL, Contant CF, Gao X, Lewin AJ, Nguyen TT. Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus. Am. J. Cardiol. 102: 434-439 (2008).

• Terzolo M, Allasino B, Bosio S, Brusa E, Daffara F, Ventura M, Aroasio E, Sacchetto G, Reimondo G, Angeli A, Camaschella C. Hyperhomocysteinemia in patients with Cushing's syndrome. J. Clin. Endocrinol. Metab. 89: 3745-3751 (2004). *

• The SEARCH Collaborative Group. SLCO1B1 variants and statin-induced myopathy - a genomewide study. N. Engl. J. Med. 359: 789-799 (2008). *

• Thomas P, Fenech M. Chapter 13. Methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease. Vitam. Horm. 79: 375-392 (2008).

• Timuragaoglu A, Dizlek S, Uysalgil N, Tosun O, Yamac K. Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy. Ann. Hematol. 85: 863-868 (2006). *

• Tinazzi I, Caramaschi P, Patuzzo G, Bambara LM, Biasi D. Homocysteine and rheumatic disease. Recenti Prog. Med. 98: 646-652 (2007).

• Toniutto P, Fabris C, Falleti E, Cussigh A, Fontanini E, Bitetto D, Fornasiere E, Minisini R, De Feo T, Marangoni F, Pirisi M. Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C. Liver Int. 28: 257-263 (2008). *

• Toohey JI. Homocysteine toxicity in connective tissue: theories, old and new. Connect. Tissue Res. 49: 57-61 (2008).

• Toth O, David M, Habon T, Nagy A, Keszthelyi Z, Kovacs N, Losonczy H. Type I antithrombin deficiency as a cause of arterial and venous thrombosis in a family with severe thrombophilia. Orv. Hetil. 146: 2121-2125 (2005).

• Trabetti E. Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk. J. Appl. Genet. 49: 267-282 (2008). *

• Triantafyllou N, Evangelopoulos ME, Kimiskidis VK, Kararizou E, Boufidou F, Fountoulakis KN, Siamouli M, Nikolaou C, Sfagos C, Vlaikidis N, Vassilopoulos D. Increased plasma homocysteine levels in patients with multiple sclerosis and depression. Ann. Gen. Psychiatry 7: 17 (2008).

• Troen AM, Shea-Budgell M, Shukitt-Hale B, Smith DE, Selhub J, Rosenberg IH. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc. Natl. Acad. Sci. U.S.A. 105: 12474-12479 (2008). *

• Tsai MY, Loria CM, Cao J, Kim Y, Siscovick D, Schreiner PJ, Hanson NQ. Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era. J. Nutr. 139: 33-37 (2009). *

• Tso TK, Huang WN. Elevation of fasting insulin and its association with cardiovascular disease risk in women with systemic lupus erythematosus. Rheumatol. Int. 29: 735-742 (2009). *

• Tso TK, Huang WN, Huang HY, Chang CK. Relationship of plasma interleukin-18 concentrations to traditional and non-traditional cardiovascular risk factors in patients with systemic lupus erythematosus. Rheumatology (Oxford) 45: 1148-1153 (2006). *

• Turner MR, Talbot K. Functional vitamin B12 deficiency. Pract. Neurol. 9: 37-45 (2009).

• Twig G, Zandman-Goddard G, Szyper-Kravitz M, Shoenfeld Y. Systemic thromboembolism in inflammatory bowel disease: mechanisms and clinical applications. Ann. N. Y. Acad. Sci. 1051: 166-173 (2005). *

• Uehara SK, Rosa G. Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene. Nutr. Res. 28: 760-766 (2008). *

• Ueland PM, Holm PI, Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin. Chem. Lab. Med. 43: 1069-1075 (2005). *

• Ukinc K, Ersoz HO, Karahan C, Erem C, Eminagaoglu S, Hacihasanoglu AB, Yilmaz M, Kocak M. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine 36: 255-261 (2009).

• Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JF 3rd, Shane B, James SJ, Reed MC, Nijhout HF. Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 17: 1822-1831 (2008). *

• Ulvik A, Ueland PM, Fredriksen A, Meyer K, Vollset SE, Hoff G, Schneede J. Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study. Hum. Genet. 121: 57-64 (2007). *

• Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM. Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol. Biomarkers Prev. 13: 2175-2180 (2004). *

• Undas A, Jankowski M, Twardowska M, Padjas A, Jakubowski H, Szczeklik A. Antibodies to N-homocysteinylated albumin as a marker for earlyonset coronary artery disease in men. Thromb. Haemost. 93: 346-350 (2005).

• Uthus EO, Ross S. Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats. Biol. Trace Elem. Res. 129: 213-220 (2009). *

• Vacek TP, Sen U, Tyagi N, Kumar M, Moshal KS, Passmore JC, Tyagi SC. Homocysteine effects classical pathway of GPCR down regulation: Galpha(q/11), Galpha (12/13), G (i/o). Mol. Cell. Biochem. 321: 1-8 (2009). *

• Vaes BL, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V, Dhonukshe-Rutten RA, Muller M, de Groot LC, Steegenga WT. Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif. Tissue Int. 84: 413-422 (2009).

• Van Bodegraven AA, Pena AS. Treatment of extraintestinal manifestations in inflammatory bowel disease. Curr. Treat. Options Gastroenterol. 6: 201-212 (2003).

• Van Dam F, Van Gool WA. Hyperhomocysteinemia and Alzheimer's disease: a systematic review. Arch. Gerontol. Geriatr. 48: 425-430 (2009).

• van der Linden IJ, den Heijer M, Afman LA, Gellekink H, Vermeulen SH, Kluijtmans LA, Blom HJ. The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. J. Mol. Med. 84: 1047-1054 (2006). *

• Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A, Palmqvist R. Low folate levels may protect against colorectal cancer. Gut 55: 1461-1466 (2006). *

• Van Guelpen BR, Wiren SM, Bergh AR, Hallmans G, Stattin PE, Hultdin J. Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study. Eur. J. Cancer Prev. 15: 46-50 (2006).

• van Rensburg SJ, Kotze MJ, Hon D, Haug P, Kuyler J, Hendricks M, Botha J, Potocnik FC, Matsha T, Erasmus RT. Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis. Metab. Brain Dis. 21: 121-137 (2006). *

• Vanek V, Budesinsky M, Kabeleova P, Sanda M, Kozisek M, Hanclova I, Mladkova J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jiracek J. Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J. Med. Chem. 52: 3652-3665 (2009). *

• Varatharajalu R, Garige M, Leckey LC, Gong M, Lakshman MR. Betaine protects chronic alcohol and omega-3 PUFA-mediated down-regulations of PON1 gene, serum PON1 and homocysteine thiolactonase activities with restoration of liver GSH. Alcohol Clin. Exp. Res. Dec 17 [Epub ahead of print] (2009).

• Varela-Moreiras G, Murphy MM, Scott JM. Cobalamin, folic acid, and homocysteine. Nutr. Rev. 67 Suppl. 1: S69-S72 (2009). *

• Vares M, Saetre P, Deng H, Cai G, Liu X, Hansen T, Rasmussen HB, Werge T, Melle I, Djurovic S, Andreassen OA, Agartz I, Hall H, Terenius L, Jonsson EG. Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia. Am. J. Med. Genet. B. Neuropsychiatr. Genet. Sep 10 [Epub ahead of print] (2009).

• Varlibas F, Cobanoglu O, Ergin B, Tireli H. Different phenotypy in three siblings with homocystinuria. Neurologist 15: 144-146 (2009).

• Vaughn JD, Bailey LB, Shelnutt KP, Dunwoody KM, Maneval DR, Davis SR, Quinlivan EP, Gregory JF 3rd, Theriaque DW, Kauwell GP. Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant. J. Nutr. 134: 2985-2990 (2004). *

• Veenema K, Solis C, Li R, Wang W, Maletz CV, Abratte CM, Caudill MA. Adequate intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load. Am. J. Clin. Nutr. 88: 685-692 (2008). *

• Ventura E, Durant R, Jaussent A, Picot MC, Morena M, Badiou S, Dupuy AM, Jeandel C, Cristol JP. Homocysteine and inflammation as main determinants of oxidative stress in the elderly. Free Radic. Biol. Med. 46: 737-744 (2009).

• Verhoef P, de Groot LC. Dietary determinants of plasma homocysteine concentrations. Semin. Vasc. Med. 5: 110-123 (2005).

• Verkleij-Hagoort A, Bliek J, Sayed-Tabatabaei F, Ursem N, Steegers E, Steegers-Theunissen R. Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis. Am. J. Med. Genet. A. 143: 952-960 (2007).

• Villanueva JA, Halsted CH. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 39: 1303-1310 (2004). *

• VITATOPS Trial Study Group, Hankey GJ, Algra A, Chen C, Wong MC, Cheung R, Wong L, Divjak I, Ferro J, de Freitas G, Gommans J, Groppa S, Hill M, Spence D, Lees K, Lisheng L, Navarro J, Ranawaka U, Ricci S, Schmidt R, Slivka A, Tan K, Tsiskaridze A, et al. VITATOPS, the VITAmins TO prevent stroke trial: rationale and design of a randomised trial of B-vitamin therapy in patients with recent transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444). Int. J. Stroke 2: 144-150 (2007).

• Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R. A functional transsulfuration pathway in brain links to glutathione homeostasis. J. Biol. Chem. 281: 35785-35793 (2006). *

• Vladimirova-Kitova LG, Deneva TI, Angelova E, Bichev AN, Nikolov FP. Role of some biomarkers of atherogenic risk in the screening for molecular defects in the low density lipoprotein receptor in severe hypercholesterolemia. Folia. Med. (Plovdiv.) 50: 14-22 (2008).

• Vollset SE, Igland J, Jenab M, Fredriksen A, Meyer K, Eussen S, Gjessing HK, Ueland PM, Pera G, Sala N, Agudo A, Capella G, Del Giudice G, Palli D, Boeing H, Weikert C, Bueno-de-Mesquita HB, Carneiro F, Pala V, Vineis P, Tumino R, Panico S, et al. The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol. Biomarkers Prev. 16: 2416-2424 (2007). *

• Von Feldt JM, Scalzi LV, Cucchiara AJ, Morthala S, Kealey C, Flagg SD, Genin A, Van Dyke AL, Nackos E, Chander A, Gehrie E, Cron RQ, Whitehead AS. Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus. Arthritis Rheum. 54: 2220-2227 (2006). *

• Vrentzos GE, Papadakis JA, Malliaraki N, Bampalis DE, Repa A, Lemonomichelaki V, Petinellis EG, Ganotakis ES. Serum homocysteine concentration as a marker of nutritional status of healthy subjects in Crete, Greece. J. Hum. Nutr. Diet. 19: 117-123 (2006). *

• Wahhab A, Isakovic L, Saavedra OM, Llewellyn DB, Claridge S, Zhan L, Bernstein N, Vaisburg A, Elowe N, Petschner AJ, Rahil J, Beaulieu N, Gauthier F, Macleod AR, Delorme D, Besterman JM. Constrained (l-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg. Med. Chem. Lett. 19: 2742-2746 (2009). *

• Wahhab A, Saavedra OM, Isakovic L, Llewellyn DB, Zhan L, Bernstein N, Claridge S, Raeppel F, Vaisburg A, Elowe N, Petschner AJ, Rahil J, Beaulieu N, Macleod AR, Delorme D, Besterman JM. SAR around (l)-S-adenosyl-L-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg. Med. Chem. Lett. 19: 2747-2751 (2009). *

• Wang JJ, Ross RJ, Tuo J, Burlutsky G, Tan AG, Chan CC, Favaloro EJ, Williams A, Mitchell P. The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration a population-based case-control study. Ophthalmology 115: 693-699 (2008).

• Wang L, Chen W, Wang J, Tan Y, Zhou Y, Ding W, Hua Z, Shen J, Xu Y, Shen H. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur. J. Cancer 42: 3206-3211 (2006). *

• Wang W, Kramer PM, Yang S, Pereira MA, Tao L. Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations. J. Chromatogr. B. Biomed. Sci. Appl. 762: 59-65 (2001).

• Weger W, Hofer A, Stanger O, Wolf P, El-Shabrawi Y, Renner W, Kerl H, Salmhofer W. The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis. Exp. Dermatol. 17: 748-751 (2008).

• Wei H, Zhang R, Jin H, Liu D, Tang X, Tang C, Du J. Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats. Antioxid. Redox Signal. Sep 21. [Epub ahead of print] (2009).

• Wei JC, Jan MS, Yu CT, Huang YC, Yang CC, Tsou HK, Lee HS, Chou CT, Tsay G, Chou MC. Plasma homocysteine status in patients with ankylosing spondylitis. Clin. Rheumatol. 26: 739-742 (2007). *

• Weijun G, Juming L, Guoqing Y, Jingtao D, Qinghua G, Yiming M, Changyu P. Effects of plasma homocysteine levels on serum HTase/PON activity in patients with type 2 diabetes. Adv. Ther. 25: 884-893 (2008).

• Weiland T, Weiller M, Kunstle G, Wendel A. Sensitization by 5-azacytidine towards death receptor-induced hepatic apoptosis. J. Pharmacol. Exp. Ther. 328: 107-115 (2009). *

• Weinstein SJ, Albanes D, Selhub J, Graubard B, Lim U, Taylor PR, Virtamo J, Stolzenberg-Solomon R. One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol. Biomarkers Prev. 17: 3233-3240 (2008). *

• Weinstein SJ, Gridley G, Harty LC, Diehl SR, Brown LM, Winn DM, Bravo-Otero E, Hayes RB. Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. J. Nutr. 132: 762-767 (2002). *

• Weng LC, Yeh WT, Bai CH, Chen HJ, Chuang SY, Chang HY, Lin BF, Chen KJ, Pan WH. Is ischemic stroke risk related to folate status or other nutrients correlated with folate intake? Stroke 39: 3152-3158 (2008). *

• Whiteman M, Moore PK. Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? J. Cell. Mol. Med. 13: 488-507 (2009).

• Wiese D, Lashner B, Seidner D. Measurement of nutrition status in Crohn's disease patients receiving infliximab therapy. Nutr. Clin. Pract. 23: 551-556 (2008).

• Wijekoon EP, Brosnan ME, Brosnan JT. Homocysteine metabolism in diabetes. Biochem. Soc. Trans. 35: 1175-1179 (2007). *

• Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes 54: 3245-3251 (2005). *

• Wilcox GM, Mattia AR. Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants. J. Clin. Gastroenterol. 40: 596-601 (2006).

• Williams KT, Schalinske KL. New insights into the regulation of methyl group and homocysteine metabolism. J. Nutr. 137: 311-314 (2007). *

• Williams KT, Schalinske KL. Homocysteine metabolism and its relation to health and disease. Biofactors Jan 20 [Epub ahead of print] (2010).

• Wilson CP, McNulty H, Scott JM, Strain JJ, Ward M. Postgraduate symposium. The MTHFR C677T polymorphism, B-vitamins and blood pressure. Proc. Nutr. Soc. Dec 3 [Epub ahead of print] (2009). *

• Wilson FA, van den Borne JJ, Calder AG, O'Kennedy N, Holtrop G, Rees WD, Lobley GE. Tissue methionine cycle activity and homocysteine metabolism in female rats: the impact of dietary methionine and folate plus choline. Am. J. Physiol. Endocrinol. Metab. 296: E702-E713 (2009). *

• Wiltshire EJ, Mohsin F, Chan A, Donaghue KC. Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. Pediatr. Diabetes 9: 348-353 (2008).

• Winkelmayer WC, Huber A, Wagner OF, Horl WH, Sunder-Plassmann G, Fodinger M. Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients. Kidney Int. 67: 1980-1985 (2005).

• Winkelmayer WC, Kramar R, Sunder-Plassmann G, Fodinger M. Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients. Kidney Int. 68: 2857-2862 (2005).

• Wong LS, Tymms KE, Buckley NA. Potential for methotrexate exposure through contamination during parenteral use as an immunosuppressant. Intern. Med. J. 39: 379-383 (2009). *

• Wu QL, Fu YF, Zhou WL, Wang JX, Feng YH, Liu J, Xu JY, He PL, Zhou R, Tang W, Wang GF, Zhou Y, Yang YF, Ding J, Li XY, Chen XR, Yuan C, Lawson BR, Zuo JP. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J. Pharmacol. Exp. Ther. 313: 705-711 (2005). *

• Xu X, Gammon MD, Zeisel SH, Bradshaw PT, Wetmur JG, Teitelbaum SL, Neugut AI, Santella RM, Chen J. High intakes of choline and betaine reduce breast cancer mortality in a population-based study. FASEB J. 23: 4022-4028 (2009). *

• Xu XY, Zhou WH, Xiao CS, Li XF, Wang LY. A clinical study of hyperhomocysteinemia in rheumatological diseases. Zhonghua Nei Ke Za Zhi 44: 111-114 (2005).

• Xu YY, Guan DY, Yang M, Wang H, Shen ZH. All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism. J. Cell. Biochem. Dec 3 [Epub ahead of print] (2009).

• Yamada K, Strahler JR, Andrews PC, Matthews RG. Regulation of human methylenetetrahydrofolate reductase by phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 102 10454-10459 (2005). *

• Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S. Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma. Cancer Epidemiol. Biomarkers Prev. 18: 267-274 (2009).

• Yang QH, Botto LD, Gallagher M, Friedman JM, Sanders CL, Koontz D, Nikolova S, Erickson JD, Steinberg K. Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am. J. Clin. Nutr. 88: 232-246 (2008). *

• Yates Z, Lucock M. G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism. Life Sci. 77: 2735-2742 (2005). *

• Yates Z, Lucock M. Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol. Genet. Metab. 79: 201-213 (2003). *

• Yazdanpanah N, Uitterlinden AG, Zillikens MC, Jhamai M, Rivadeneira F, Hofman A, de Jonge R, Lindemans J, Pols HA, van Meurs JB. Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR TT allele. J. Bone Miner. Res. 23: 86-94 (2008). *

• Yehuda S, Sredni B, Carasso RL, Kenigsbuch-Sredni D. REM sleep deprivation in rats results in inflammation and IL-17 elevation. J. Interferon Cytokine Res. 29: 393-398 (2009).

• Yesilova Z, Pay S, Oktenli C, Musabak U, Saglam K, Sanisoglu SY, Dagalp K, Erbil MK, Kocar IH. Hyperhomocysteinemia in patients with Behcet's disease: is it due to inflammation or therapy? Rheumatol. Int. 25: 423-428 (2005). *

• Yi J, Jie Z, Ting J, Liuqing G, Feng Z, Zhitao C, Yuan L, Sha H, Bing X. Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China. J. Gastroenterol. Hepatol. [In Press] (2010). *

• Yilmaz E, Akar R, Eker ST, Deda G, Adiguzel Y, Akar N. Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and atherosclerosis, ischemic stroke and hyperhomocysteinemia. Mol. Biol. Rep. Aug 11 [Epub ahead of print] (2009). *

• Yilmaz S, Bayan K, Tuzun Y, Batun S, Altintas A. A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. J. Thromb. Thrombolysis 22: 205-212 (2006). *

• Younes-Mhenni S, Derex L, Berruyer M, Nighoghossian N, Philippeau F, Salzmann M, Trouillas P. Large-artery stroke in a young patient with Crohn's disease. Role of vitamin B(6) deficiency-induced hyperhomocysteinemia. J. Neurol. Sci. 221: 113-115 (2004). *

• Zalups RK, Ahmad S. Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. J. Am. Soc. Nephrol. 15: 2023-2031 (2004). *

• Zammiti W, Mtiraoui N, Mahjoub T. Lack of consistent association between endothelial nitric oxide synthase gene polymorphisms, homocysteine levels and recurrent pregnancy loss in Tunisian women. Am. J. Reprod. Immunol. 59: 139-145 (2008). *

• Zee RY, Mora S, Cheng S, Erlich HA, Lindpaintner K, Rifai N, Buring JE, Ridker PM. Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women. Clin. Chem. 53: 845-851 (2007). *

• Zeisel SH, Zola T, daCosta KA, Pomfret EA. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem. J. 259: 725-729 (1989). *

• Zeman M, Zak A, Vecka M, Tvrzicka E, Pisarikova A, Stankova B. n-3 Fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J. Nutr. Biochem. 17: 379-384 (2006). *

• Zeman M, Zak A, Vecka M, Tvrzicka E, Pisarikova A, Stankova B. Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination. Cas. Lek. Cesk. 144: 737-741 (2005).

• Zepeda-Gomez S, Montano-Loza A, Zapata-Colindres JC, Vargas-Vorackova F, Majluf-Cruz A, Uscanga L. Oral challenge with a methionine load in patients with inflammatory bowel disease: a better test to identify hyperhomocysteinemia. Inflamm. Bowel Dis. 14: 383-388 (2008). *

• Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis N. Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J. Gastroenterol. 11: 6038-6042 (2005). *

• Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ. Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am. J. Pathol. 174: 1481-1491 (2009). *

• Zhang HY, Luo GA, Liang QL, Wang Y, Yang HH, Wang YM, Zheng XY, Song XM, Chen G, Zhang T, Wu JX. Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism. Exp. Neurol. 212: 515-521 (2008).

• Zhang L, Miyaki K, Araki J, Nakayama T, Muramatsu M. The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men. Thromb. Res. 121: 55-58 (2007). *

• Zhang X, Chen S, Li L, Wang Q, Le W. Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1(G93A) transgenic mice. Neuropharmacology 54: 1112-1119 (2008).

• Zholudev A, Rifai N, Zurakowski D, Bousvaros A. Normal homocysteine levels in a population of children with inflammatory bowel disease. Inflamm. Bowel Dis. 11: 620-621 (2005). *

• Zhou J, Werstuck GH, Lhotak S, Shi YY, Tedesco V, Trigatti B, Dickhout J, Majors AK, Dibello PM, Jacobsen DW, Austin RC. Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. FASEB J. 22: 2569-2578 (2008). *

• Zhou Q, Ji X, Chen L, Greenberg HB, Lu SC, Omary MB. Keratin mutation primes mouse liver to oxidative injury. Hepatology 41: 517-525 (2005). *

• Zhou XM, Lin JS, Sun XM, Tang WX, Zhang WY, Yuan SY, Ai L. The relationship between the plasma homocysteine level and the polymorphism of MTHFR gene C667T in liver cirrhosis. Zhonghua Gan Zang Bing Za Zhi 13: 908-910 (2005).

• Zhu BT. CNS dopamine oxidation and catechol-O-methyltransferase: importance in the etiology, pharmacotherapy, and dietary prevention of Parkinson's disease. Int. J. Mol. Med. 13: 343-353 (2004).

• Zhu H, Curry S, Wen S, Wicker NJ, Shaw GM, Lammer EJ, Yang W, Jafarov T, Finnell RH. Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? Am. J. Med. Genet. 135A: 274-277 (2005).

• Zhu W, Lin A, Banerjee R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase. Biochemistry 47: 6226-6232 (2008). *

• Zijno A, Andreoli C, Leopardi P, Marcon F, Rossi S, Caiola S, Verdina A, Galati R, Cafolla A, Crebelli R. Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects. Carcinogenesis 24: 1097-1103 (2003). *

• Zimny J. Mechanisms that protect against homocysteine toxicity. Postepy. Biochem. 54: 91-98 (2008).

• Zinellu A, Carru C, Sotgia S, Deiana L. Plasma d-penicillamine redox state evaluation by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 803: 299-304 (2004). *

• Zintzaras E. Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies. Biomarkers 15: 69-79 (2010).

• Zintzaras E. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. J. Hum. Genet. 52: 943-953 (2007). *

• Zoccali C, Mallamaci F, Tripepi G. It is important to lower homocysteine in dialysis patients. Semin. Dial. 20: 530-533 (2007).

• Zou CG, Gao SY, Zhao YS, Li SD, Cao XZ, Zhang Y, Zhang KQ. Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells. J. Mol. Med. 87: 75-84 (2009). *

• Zulli A, Lau E, Wijaya BP, Jin X, Sutarga K, Schwartz GD, Learmont J, Wookey PJ, Zinello A, Carru C, Hare DL. High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery. Association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia. Hypertension 53: 1017-1022 (2009).

• Zuntar I, Antoljak N, Vrkic N, Topic E, Kujundzic N, Demarin V, Vukovic V. Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis. Coll. Antropol. 30: 871-878 (2006).

Number of references = 878

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