• Abe M, Thomson AW. Chapter 4. Antigen processing and presentation in the liver. In "Liver Immunology: Principles and Practice" (eds. Gershwin ME, Vierling JM, Manns MP), Humana Press Inc., Totowa, NJ, p. 49-59 (2007). *

• Abe M, Yokoyama Y, Syuto T, Ishibuchi H, Ishikawa O. Interleukin-6 counteracts effects of cyclosporin A on extracellular matrix metabolism by human dermal fibroblasts. Cell Tissue Res. 333: 281-288 (2008). *

• Abraham C, Cho JH. IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 60: 97-110 (2009). *

• Abraham M, Karni A, Dembinsky A, Miller A, Gandhi R, Anderson D, Weiner HL. In vitro induction of regulatory T cells by anti-CD3 antibody in humans. J. Autoimmun. 30: 21-28 (2008). *

• Abreu MT. The pathogenesis of inflammatory bowel disease: translational implications for clinicians. Curr. Gastroenterol. Rep. 4: 481-489 (2002).

• Accurso FJ, Sontag MK. Gene modifiers in cystic fibrosis. J. Clin. Invest. 118: 839-841 (2008). *

• Acevedo N, Vergara C, Gusmao L, Jimenez S, Martinez B, Mercado D, Caraballo L. The C-509T promoter polymorphism of the transforming growth factor beta-1 gene is associated with levels of total and specific IgE in a Colombian population. Int. Arch. Allergy Immunol. 151: 237-246 (2009).

• Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8: 942-949 (2007). *

• Acton JD, Wilmott RW. Phenotype of CF and the effects of possible modifier genes. Paediatr. Respir. Rev. 2: 332-339 (2001).

• Adams J, Kiss E, Arroyo AB, Bonrouhi M, Sun Q, Li Z, Gretz N, Schnitger A, Zouboulis CC, Wiesel M, Wagner J, Nelson PJ, Grone HJ. 13-cis Retinoic acid inhibits development and progression of chronic allograft nephropathy. Am. J. Pathol. 167: 285-298 (2005). *

• Adcock K, Hedberg C, Loggins J, Kruger TE, Baier RJ. The TNF-alpha -308, MCP-1 -2518 and TGF-beta1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants. Genes Immun. 4: 420-426 (2003). *

• Adler AJ. Mechanisms of T cell tolerance and suppression in cancer mediated by tumor-associated antigens and hormones. Curr. Cancer Drug Targets 7: 3-14 (2007).

• Adler EM. IL-2 antagonizes Th17 differentiation. Sci. STKE 379: tw103 (2007).

• Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 148: 32-46 (2007). *

• Afzali B, Mitchell P, Lechler RI, John S, Lombardi G. Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin. Exp. Immunol. 159: 120-130 (2010). *

• Agarwal R, Agarwal C, Ichikawa H, Singh RP, Aggarwal BB. Anticancer potential of silymarin: from bench to bed side. Anticancer Res. 26: 4457-4498 (2006).

• Aharoni R, Aizman E, Fuchs O, Arnon R, Yaffe D, Sarig R. Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 215: 73-83 (2009).

• Aharoni R, Brenner O, Cohen A, Arnon R. The therapeutic effect of TV-5010 in a murine model of inflammatory bowel disease - dextran induced colitis. Int. Immunopharmacol. 8: 1578-1588 (2008).

• Aharoni R, Kayhan B, Arnon R. Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitis. Inflamm. Bowel Dis. 11: 106-115 (2005). *

• Aharoni R, Kayhan B, Brenner O, Domev H, Labunskay G, Arnon R. Immunomodulatory therapeutic effect of glatiramer acetate on several murine models of inflammatory bowel disease. J. Pharmacol. Exp. Ther. 318: 68-78 (2006). *

• Aharoni R, Sonego H, Brenner O, Eilam R, Arnon R. The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cells. Immunol. Lett. 112: 110-119 (2007).

• Aherrahrou Z, Axtner SB, Kaczmarek PM, Jurat A, Korff S, Doehring LC, Weichenhan D, Katus HA, Ivandic BT. A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. Am. J. Pathol. 164: 1379-1387 (2004). *

• Ahmed MB, Belhadj Hmida N, Moes N, Buyse S, Abdeladhim M, Louzir H, Cerf-Bensussan N. IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway. J. Immunol. 182: 6763-6770 (2009).

• Ahn JS, Krishnadas DK, Agrawal B. Dendritic cells partially abrogate the regulatory activity of CD4+CD25+ T cells present in the human peripheral blood. Int. Immunol. 19: 227-237 (2007).

• Aitken AE, Morgan E. Gene-specific effects of inflammatory cytokines on cytochrome P4502C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab. Dispos. 35: 1687-1693 (2007). *

• Akasaka Y, Abe K, Sato T, Inoue H. Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis. Neuropeptides 39: 467-474 (2005). *

• Akimzhanov AM, Yang XO, Dong C. Chromatin remodeling at interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282: 5969-5972 (2007). *

• Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE Jr, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46: 3340-3348 (2002). *

• Al-Sadi R, Boivin M, Ma T. Mechanism of cytokine modulation of epithelial tight junction barrier. Front. Biosci. 14: 2765-2778 (2009).

• Al-Salleeh F, Petro TM. Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages. J. Immunol. 181: 4523-4533 (2008). *

• Alansari A, Hajeer A, Teh LS, Bayat A, Mysercough A, Gul A, Inanc M, Ordi-Ros J, Ollier W. Transforming growth factor-12 polymorphism and systemic lupus erythematosus. J. Rheumatol. 29: 1189-1191 (2002).

• Alansari A, Hajeer AH, Bayat A, Eyre S, Carthy D, Ollier WE. Two novel polymorphisms in the human transforming growth factor beta 2 gene. Genes Immun. 2: 295-296 (2001). *

• Alayli G, Kara N, Tander B, Canturk F, Gunes S, Bagci H. Association of transforming growth factor beta1 gene polymorphism with rheumatoid arthritis in a Turkish population. Joint Bone Spine 76: 20-23 (2009). *

• Aldhous MC, Prescott RJ, Roberts S, Samuel K, Waterfall M, Satsangi J. Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease? Inflamm. Bowel Dis. 14: 1469-1482 (2008). *

• Alexis NE, Brickey WJ, Lay JC, Wang Y, Roubey RA, Ting JP, Peden DB. Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individuals. Ann. Allergy Asthma Immunol. 100: 206-215 (2008).

• Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M. TLR2-activated human Langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol. 39: 1221-1230 (2009). *

• Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc. Natl. Acad. Sci. U.S.A. 104: 2827-2830 (2007). *

• Alisa A, Boswell S, Pathan AA, Ayaru L, Williams R, Behboudi S. Human CD4+ T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4+ T cells. J. Immunol. 180: 5109-5117 (2008). *

• Allen CE, Richards J, Muthusamy N, Auer H, Liu Y, Robinson ML, Barnard JA, Wu LC. Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development. Gene Expr. 14: 83-100 (2007).

• Allez M, Mayer L. Regulatory T cells: peace keepers in the gut. Inflamm. Bowel Dis. 10: 666-676 (2004). *

• Alvarado-Sanchez B, Hernandez-Castro B, Portales-Perez D, Baranda L, Layseca-Espinosa E, Abud-Mendoza C, Cubillas-Tejeda AC, Gonzalez-Amaro R. Regulatory T cells in patients with systemic lupus erythematosus. J. Autoimmun. 27: 110-118 (2006).

• Amani D, Farjadian S, Ghaderi A. The frequency of transforming growth factor-beta1 gene polymorphisms in a normal southern Iranian population. Int. J. Immunogenet. 35: 145-151 (2008). *

• Amaral JD, Castro RE, Sola S, Steer CJ, Rodrigues CM. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. J. Biol. Chem. 282: 34250-34259 (2007). *

• Amaral JD, Correia AR, Steer CJ, Gomes CM, Rodrigues CM. No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain. Biosci. Rep. Oct 7 [Epub ahead of print] (2009). *

• Amarnath S, Dong L, Li J, Wu Y, Chen W. Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells. Retrovirology 4: 57 (2007).

• Ambrogini E, Toraldo G, Marcocci C. Post-menopausal osteoporosis: is it an autoimmune disease? J. Endocrinol. Invest. 28: S43-S47 (2005).

• Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone 44: 1143-1150 (2009). *

• Amirghofran Z, Jalali SA, Ghaderi A, Hosseini SV. Genetic polymorphism in the transforming growth factor beta1 gene (-509 C/T and -800 G/A) and colorectal cancer. Cancer Genet. Cytogenet. 190: 21-25 (2009).

• Amirzargar AA, Naroueynejad M, Khosravi F, Dianat S, Rezaei N, Mytilineos J, Nikbin B. Cytokine single nucleotide polymorphisms in Iranian populations. Eur. Cytokine Netw. 19: 104-112 (2008).

• Amirzargar M, Yavangi M, Basiri A, Moghadam SH, Khosravi F, Solgi G, Gholiaf M, Khoshkho F, Dadaras F, Mahmmodi M, Ansaripour B, Amirzargar A, Nikbin B. Genetic association of interleukin-4, interleukin-10, and transforming growth factor-beta gene polymorphism with allograft function in renal transplant patients. Transplant. Proc. 39: 954-957 (2007). *

• Amore A, Coppo R, Roccatello D, Piccoli G, Mazzucco G, Gomez-Chiarri M, Lamm ME, Emancipator SN. Experimental IgA nephropathy secondary to hepatocellular injury induced by dietary deficiencies and heavy alcohol intake. Lab. Invest. 70: 68-77 (1994).

• Amoudruz P, Holmlund U, Schollin J, Sverremark-Ekstrom E, Montgomery SM. Maternal country of birth and previous pregnancies are associated with breast milk characteristics. Pediatr. Allergy Immunol. 20: 19-29 (2009).

• Amu S, Tarkowski A, Dorner T, Bokarewa M, Brisslert M. The human immunomodulatory CD25(+) B cell population belongs to the memory B cell pool. Scand. J. Immunol. 66: 77-86 (2007). *

• An WS, Kim HJ, Cho KH, Vaziri ND. Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation and tubulo-interstitial fibrosis in the remnant kidney. Am. J. Physiol. Renal Physiol. 297: F895-F903 (2009). *

• Ancuta C, Ancuta E, Iordache C, Ceausu M, Chirieac R. Immunohistochemical study of skeletal muscle in rheumatoid myositis. Rom. J. Morphol. Embryol. 50: 223-227 (2009).

• Andersson A, Isaksson M, Wefer J, Norling A, Flores-Morales A, Rorsman F, Kampe O, Harris RA, Lobell A. Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. PLoS ONE 3: e3682 (2008). *

• Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, Shevach EM. CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J. Exp. Med. 205: 1975-1981 (2008). *

• Ando Y, Inaba M, Sakaguchi Y, Tsuda M, Quan GK, Omae M, Okazaki K, Ikehara S. Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Inflamm. Bowel Dis. 14: 826-838 (2008). *

• Andre S, Tough DF, Lacroix-Desmazes S, Kaveri SV, Bayry J. Surveillance of antigen-presenting cells by CD4+CD25+ regulatory T cells in autoimmunity. Immunopathogenesis and therapeutic implications. Am. J. Pathol. 174: 1575-1587 (2009). *

• Andreas K, Haupl T, Lubke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C. Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res. Ther. 11: R15 (2009). *

• Anger T, Ekici AB, Daniel WG, Garlichs CD. Gene polymorphisms leading to calcified and stenotic aortic valves. Herz. 31: 635-643 (2006).

• Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C. Regulation of IL-9 expression by IL-25 signaling. Nat. Immunol. Feb 14 [Epub ahead of print] (2010). *

• Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int. Immunol. 20: 1361-1368 (2008). *

• Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Type 17 T helper cells - origins, features and possible roles in rheumatic disease. Nat. Rev. Rheumatol. 5: 325-331 (2009).

• Annunziato F, Romagnani S. Do studies in humans better depict Th17 cells? Blood 114: 2213-2219 (2009). *

• Ansorge S, Bank U, Heimburg A, Helmuth M, Koch G, Tadje J, Lendeckel U, Wolke C, Neubert K, Faust J, Fuchs P, Reinhold D, Thielitz A, Tager M. Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin. Chem. Lab. Med. 47: 253-261 (2009).

• Anthoni M, Fyhrquist N, Lehtimaki S, Alenius H, Wolff H, Lauerma A. Smad3 regulates dermal cytokine and chemokine expression and specific antibody production in murine responses to a respiratory chemical sensitizer. Int. Arch. Allergy Immunol. 151: 155-167 (2009).

• Anthoni M, Fyhrquist-Vanni N, Wolff H, Alenius H, Lauerma A. Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity. Br. J. Dermatol. 159: 546-554 (2008). *

• Antiga E, Quaglino P, Bellandi S, Volpi W, Del Bianco E, Comessatti A, Osella-Abate S, De Simone C, Marzano A, Bernengo MG, Fabbri P, Caproni M. Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphea. Br. J. Dermatol. Jan 22 [Epub ahead of print] (2010). *

• Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology 136: 2325-2333 (2009). *

• Antonson P, Jakobsson T, Almlof T, Guldevall K, Steffensen KR, Gustafsson JA. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with SMAD2 and SMAD3. J. Biol. Chem. 283: 8995-9001 (2008). *

• Aoki CA, Borchers AT, Li M, Flavell RA, Bowlus CL, Ansari AA, Gershwin ME. Transforming growth factor beta (TGF-beta) and autoimmunity. Autoimmun. Rev. 4: 450-459 (2005).

• Aoki Y, Maeno T, Aoyagi K, Ueno M, Aoki F, Aoki N, Nakagawa J, Sando Y, Shimizu Y, Suga T, Arai M, Kurabayashi M. Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. Respiration 77: 311-319 (2009).

• Apostolou I, Verginis P, Kretschmer K, Polansky J, Huhn J, von Boehmer H. Peripherally induced Treg: mode, stability, and role in specific tolerance. J. Clin. Immunol. 28: 619-624 (2008). *

• Araki Y, Sugihara H, Hattori T. In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis. Oncol. Rep. 16: 1357-1362 (2006). *

• Aranami T, Yamamura T. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 57: 115-120 (2008). *

• Araujo FA, Rocha MA, Mendes JB, Andrade SP. Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1. Biomed. Pharmacother. Sep 8 [Epub ahead of print] (2009).

• Argano C, Duro G, Corrao S, Di Chiara T, Nuzzo D, Colomba D, Scaglione R, Licata G. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press. 17: 220-226 (2008).

• Argast GM, Campbell JS, Brooling JT, Fausto N. Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication. J. Biol. Chem. 279: 34530-34536 (2004). *

• Aricha R, Feferman T, Fuchs S, Souroujon MC. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. J. Immunol. 180: 2132-2139 (2008). *

• Armendariz-Borunda J, Rincon AR, Munoz-Valle JF, Bueno-Topete M, Oregon-Romero E, Islas-Carbajal MC, Medina-Preciado D, Gonzalez-Garcia I, Bautista CA, Garcia-Rocha S, Godoy J, Vazquez-Del Mercado M, Troyo-Sanroman R, Arellano-Olivera I, Lucano S, et al. Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment. J. Investig. Med. 56: 944-953 (2008).

• Arranz A, Juarranz Y, Leceta J, Gomariz RP, Martinez C. VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4. Peptides 29: 948-956 (2008). *

• Artaza J, Norris K. Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J. Endocrinol. 200: 207-221 (2009). *

• Arthur AT, Armati PJ, Bye C, Consortium SM, Heard RN, Stewart GJ, Pollard JD, Booth DR. Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med. Genet. 9: 17 (2008). *

• Aruna BV, Sela M, Mozes E. Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells. Proc. Natl. Acad. Sci. U.S.A. 102: 10285-10290 (2005). *

• Asano Y. Future treatments in systemic sclerosis. J. Dermatol. 37: 54-70 (2010).

• Asano Y, Ihn H, Jinnin M, Mimura Y, Tamaki K. Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma. J. Invest. Dermatol. 126: 1761-1769 (2006). *

• Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J. Immunol. 175: 7708-7718 (2005). *

• Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J. Clin. Invest. 113: 253-264 (2004). *

• Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, de Water JV. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J. Neuroimmunol. 204: 149-153 (2008).

• Ashwood P, Harvey R, Verjee T, Wolstencroft R, Thompson RP, Powell JJ. Functional interactions between mucosal IL-1, IL-ra and TGF-beta 1 in ulcerative colitis. Inflamm. Res. 53: 53-59 (2004). *

• Askenasy N, Kaminitz A, Yarkoni S. Mechanisms of T regulatory cell function. Autoimmun. Rev. 7: 370-375 (2008).

• Asquith DL, McInnes IB. Emerging cytokine targets in rheumatoid arthritis. Curr. Opin. Rheumatol. 19: 246-251 (2007). *

• Asseman C, Fowler S, Powrie F. Control of experimental inflammatory bowel disease by regulatory T cells. Am. J. Respir. Crit. Care Med. 162: S185-S189 (2000). *

• Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004 (1999). *

• Atalar K, Afzali B, Lord G, Lombardi G. Relative roles of Th1 and Th17 effector cells in allograft rejection. Curr. Opin. Organ Transplant. 14: 23-29 (2009).

• Aujla SJ, Dubin PJ, Kolls JK. Th17 cells and mucosal host defense. Semin. Immunol. 19: 377-382 (2007). *

• Austin AS, Haas KM, Naugler SM, Bajer AA, Garcia-Tapia D, Estes DM. Identification and characterization of a novel regulatory factor: IgA-inducing protein. J. Immunol. 171: 1336-1342 (2003). *

• Autenrieth IB, Bucheler N, Bohn E, Heinze G, Horak I. Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 41: 793-800 (1997). *

• Auth MK, Kim HS, Beste M, Bonzel KE, Baumann U, Ballauff A, Wallot M, Borchers T, Vester U, Grasemann C, Hauffa B, Hoyer PF, Gerken G, Voit T. Removal of metabolites, cytokines and hepatic growth factors by extracorporeal liver support in children. J. Pediatr. Gastroenterol. Nutr. 40: 54-59 (2005). *

• Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8: 1380-1389 (2007). *

• Awasthi A, Kuchroo VK. Th17 cells: from precursors to players in inflammation and infection. Int. Immunol. 21: 489-498 (2009).

• Ayoub SS, Botting RM, Joshi AN, Seed MP, Colville-Nash PR. Activation of macrophage peroxisome proliferator-activated receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines. Mol. Cell. Biochem. 327: 101-110 (2009). *

• Aytekin C, Dogu F, Ikinciogullari A, Egin Y, Yuksek M, Bozdogan G, Akar N, Babacan E. TGF-beta1-915G/C and TNF-alpha-308G/A polymorphisms in children with asthma. Tuberk. Toraks. 57: 62-67 (2009).

• Azzi A, Gysin R, Kempna P, Munteanu A, Negis Y, Villacorta L, Visarius T, Zingg JM. Vitamin E mediates cell signaling and regulation of gene expression. Ann. N. Y. Acad. Sci. 1031: 86-95 (2004). *

• Azzi A, Gysin R, Kempna P, Munteanu A, Villacorta L, Visarius T, Zingg JM. Regulation of gene expression by alpha-tocopherol. Biol. Chem. 385: 585-591 (2004).

• Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M. Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J. Leukoc. Biol. 84: 468-476 (2008). *

• Babel N, Vergopoulos A, Trappe RU, Oertel S, Hammer MH, Karaivanov S, Schneider N, Riess H, Papp-Vary M, Neuhaus R, Gondek LP, Volk HD, Reinke P. Evidence for genetic susceptibility towards development of posttransplant lymphoproliferative disorder in solid organ recipients. Transplantation 84: 387-391 (2007).

• Babu S, Bhat SQ, Pavan Kumar N, Lipira AB, Kumar S, Karthik C, Kumaraswami V, Nutman TB. Filarial lymphedema is characterized by antigen-specific Th1 and Th17 proinflammatory responses and a lack of regulatory T cells. PLoS Negl. Trop. Dis. 3: e420 (2009). *

• Babu S, Blauvelt CP, Kumaraswami V, Nutman TB. Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J. Immunol. 176: 3248-3256 (2006). *

• Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 110: 975-984 (1996). *

• Bacchetta R, Gregori S, Roncarolo MG. CD4(+) regulatory T cells: mechanisms of induction and effector function. Autoimmun. Rev. 4: 491-496 (2005).

• Bach JF. Current concepts of autoimmunity. Rev. Neurol. (Paris) 158: 881-886 (2002).

• Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, Schmid-Kotsas A, Adler G. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128: 907-921 (2005). *

• Bae JS, Gutierrez S, Narla R, Pratap J, Devados R, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Javed A. Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J. Cell. Biochem. 100: 434-449 (2007).

• Bae SC, Choi JK. Tumor suppressor activity of RUNX3. Oncogene 23: 4336-4340 (2004). *

• Bagnyukova TV, Tryndyak VP, Muskhelishvili L, Ross SA, Beland FA, Pogribny IP. Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Cell Cycle 7: 3202-3210 (2008). *

• Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A. Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis. Inflammation 31: 215-221 (2008). *

• Bai A, Lu N, Guo Y, Liu Z, Chen J, Peng Z. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J. Leukoc. Biol. 86: 959-969 (2009). *

• Bai J, Wang S, Liu J, Ye Z, Yu X, Xi Q, Hu D, Su S. Characterization of circulating CD4(+)CD25(high) regulatory T cells in men with chronic prostatitis/chronic pelvic pain syndrome. Urology Oct 1 [Epub ahead of print] (2009).

• Bai Y, Liu R, Huang D, La Cava A, Tang YY, Iwakura Y, Campagnolo DI, Vollmer TL, Ransohoff RM, Shi FD. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur. J. Immunol. 38: 1877-1888 (2008). *

• Bailey SL, Schreiner B, McMahon EJ, Miller SD. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4(+) T(H)-17 cells in relapsing EAE. Nat. Immunol. 8: 172-180 (2007). *

• Baker VS, Imade GE, Molta NB, Tawde P, Pam SD, Obadofin MO, Sagay SA, Egah DZ, Iya D, Afolabi BB, Baker M, Ford K, Ford R, Roux KH, Keller TC 3rd. Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age. Malar. J. 7: 41 (2008). *

• Balic I, Angel B, Codner E, Carrasco E, Perez-Bravo F. Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children. Hum. Immunol. 70: 116-120 (2009).

• Balkowiec-Iskra E, Kurkowska-Jastrzebska I, Joniec I, Ciesielska A, Muszynska A, Przybylkowski A, Czlonkowska A, Czlonkowski A. MPTP-induced central dopamine depletion exacerbates experimental autoimmune encephalomyelitis (EAE) in C57BL mice. Inflamm. Res. 56: 311-317 (2007). *

• Ballow M, Xiang S, Wang W, Brodsky L. The effects of retinoic acid on immunoglobulin synthesis: role of interleukin 6. J. Clin. Immunol. 16: 171-179 (1996).

• Bank U, Heimburg A, Helmuth M, Stefin S, Lendeckel U, Reinhold D, Faust J, Fuchs P, Sens B, Neubert K, Tager M, Ansorge S. Triggering endogenous immunosuppressive mechanisms by combined targeting of dipeptidyl peptidase IV (DPIV/CD26) and aminopeptidase N (APN/ CD13) - a novel approach for the treatment of inflammatory bowel disease. Int. Immunopharmacol. 6: 1925-1934 (2006).

• Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S, Serhan CN. Molecular circuits of resolution: formation and actions of resolvins and protectins. J. Immunol. 174: 4345-4355 (2005). *

• Baran W, Szepietowski JC, Mazur G, Baran E. TGF-beta(1) gene polymorphism in psoriasis vulgaris. Cytokine 38: 8-11 (2007).

• Baranek T, Debret R, Antonicelli F, Lamkhioued B, Belaaouaj A, Hornebeck W, Bernard P, Guenounou M, Le Naour R. Elastin receptor (spliced galactosidase) occupancy by elastin peptides counteracts proinflammatory cytokine expression in lipopolysaccharide-stimulated human monocytes through NF-kappaB down-regulation. J. Immunol. 179: 6184-6192 (2007). *

• Barao I, Hanash AM, Hallett W, Welniak LA, Sun K, Redelman D, Blazar BR, Levy RB, Murphy WJ. Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 103: 5460-5465 (2006). *

• Baraut J, Farge D, Jean-Louis F, Kesmandt H, Durant C, Verrecchia F, Michel L. Cytokines in systemic sclerosis. Pathol. Biol. (Paris) Jan 28 [Epub ahead of print] (2010).

• Barisani D, Ceroni S, Meneveri R, Cesana BM, Bardella MT. IL-10 polymorphisms are associated with early-onset celiac disease and severe mucosal damage in patients of Caucasian origin. Genet. Med. 8: 169-174 (2006).

• Barreto M, Ferreira RC, Lourenco L, Moraes-Fontes MF, Santos E, Alves M, Carvalho C, Martins B, Andreia R, Viana JF, Vasconcelos C, Mota-Vieira L, Ferreira C, Demengeot J, Vicente AM. Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGF beta gene variants. BMC Immunol. 10: 5 (2009). *

• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307: 1621-1625 (2005). *

• Bartfai Z, Gaede KI, Russell KA, Murakozy G, Muller-Quernheim J, Specks U. Different gender-associated genotype risks of Wegener's granulomatosis and microscopic polyangiitis. Clin. Immunol. 109: 330-337 (2003). *

• Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Leon S, Treilleux I, Rimokh R, Marie JC. Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor. Genesis 46: 724-731 (2008). *

• Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, Wotton D. TGIF inhibits retinoid signaling. Mol. Cell. Biol. 26: 990-1001 (2006). *

• Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemkova D, et al. Genetic modifiers of liver disease in cystic fibrosis. JAMA 302: 1076-1083 (2009). *

• Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB. The role of helper and regulatory T cells in the pathogenesis of vitiligo. J. Am. Acad. Dermatol. 60: 256-260 (2009).

• Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127: 777-791 (2004). *

• Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol. Carcinog. 44: 151-161 (2005). *

• Basso AS, Cheroutre H, Mucida D. More stories on Th17 cells. Cell Res. 19: 399-411 (2009).

• Basta-Kaim A, Budziszewska B, Lason W. Effects of antiepileptic drugs on immune system. Przegl. Lek. 65: 799-802 (2008).

• Basturk B, Karasu Z, Kilic M, Ulukaya S, Boyacioglu S, Oral B. Association of TNF-alpha -308 polymorphism with the outcome of hepatitis B virus infection in Turkey. Infect. Genet. Evol. 8: 20-25 (2008).

• Bataille F, Rohrmeier C, Bates R, Weber A, Rieder F, Brenmoehl J, Strauch U, Farkas S, Furst A, Hofstadter F, Scholmerich J, Herfarth H, Rogler G. Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease. Inflamm. Bowel Dis. 14: 1514-1527 (2008). *

• Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin. Liver Dis. 21: 437-451 (2001).

• Bataller R, Brenner DA. Liver fibrosis. J. Clin. Invest. 115: 209-218 (2005). *

• Bataller R, Gabele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology 41: 1046-1055 (2005). *

• Bathgate AJ, Pravica V, Perrey C, Hayes PC, Hutchinson IV. Polymorphisms in tumour necrosis factor alpha, interleukin-10 and transforming growth factor beta1 genes and end-stage liver disease. Eur. J. Gastroenterol. Hepatol. 12: 1329-1333 (2000).

• Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7: 929-936 (2006). *

• Baumgart DC, Vierziger K, Sturm A, Wiedenmann B, Dignass AU. Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism. Scand. J. Gastroenterol. 40: 958-964 (2005). *

• Baus-Loncar M, Lubka M, Pusch CM, Otto WR, Poulsom R, Blin N. Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells. Cell. Physiol. Biochem. 20: 193-204 (2007). *

• Bayat A, Stanley JK, Watson JS, Ferguson MW, Ollier WE. Genetic susceptibility to Dupuytren's disease: transforming growth factor beta receptor (TGFbetaR) gene polymorphisms and Dupuytren's disease. Br. J. Plast. Surg. 56: 328-333 (2003).

• Bayat A, Watson JS, Stanley JK, Alansari A, Shah M, Ferguson MW, Ollier WE. Genetic susceptibility in Dupuytren's disease. TGF-beta1 polymorphisms and Dupuytren's disease. J. Bone Joint Surg. Br. 84: 211-215 (2002).

• Bayat A, Watson JS, Stanley JK, Ferguson MW, Ollier WE. Genetic susceptibility to Dupuytren disease: association of Zf9 transcription factor gene. Plast. Reconstr. Surg. 111: 2133-2139 (2003).

• Bazzone LE, Smith PM, Rutitzky LI, Shainheit MG, Urban JF, Setiawan T, Blum AM, Weinstock JV, Stadecker MJ. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis. Infect. Immun. 76: 5164-5172 (2008). *

• Beagley KW, Elson CO. Cells and cytokines in mucosal immunity and inflammation. Gastroenterol. Clin. North Am. 21: 347-366 (1992).

• Beagley KW, Fujihashi K, Lagoo AS, Lagoo-Deenadaylan S, Black CA, Murray AM, Sharmanov AT, Yamamoto M, McGhee JR, Elson CO, et al. Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. J. Immunol. 154: 5611-5619 (1995).

• Bechmann LP, Zahn D, Gieseler RK, Fingas CD, Marquitan G, Jochum C, Gerken G, Friedman SL, Canbay A. Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells. Hepatol. Res. 39: 601-608 (2009). *

• Beck PL, Podolsky DK. Growth factors in inflammatory bowel disease. Inflamm. Bowel Dis. 5: 44-60 (1999). *

• Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21: 491-501 (2004). *

• Becker C, Fantini MC, Wirtz S, Nikolaev A, Lehr HA, Galle PR, Rose-John S, Neurath MF. IL-6 signaling promotes tumor growth in colorectal cancer. Cell Cycle 4: 217-220 (2005). *

• Becker T, Jansen S, Tamm S, Wienker TF, Tummler B, Stanke F. Transmission ratio distortion and maternal effects confound the analysis of modulators of cystic fibrosis disease severity on 19q13. Eur. J. Hum. Genet. 15: 774-778 (2007). *

• Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, O'Connell PR. Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease. Br. J. Surg. 93: 1290-1296 (2006). *

• Beddy D, Watson RW, Fitzpatrick JM, O'Connell PR. Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease. Br. J. Surg. 91: 72-77 (2004). *

• Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV. TGF-beta regulates T-cell neurokinin-1 receptor internalization and function. Proc. Natl. Acad. Sci. U.S.A. Feb 16 [Epub ahead of print] (2010). *

• Beisswenger C, Lysenko ES, Weiser JN. Early bacterial colonization induces TLR-dependent TGF-beta signaling in epithelium. Infect. Immun. 77: 2212-2220 (2009). *

• Beiting DP, Gagliardo LF, Hesse M, Bliss SK, Meskill D, Appleton JA. Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta. J. Immunol. 178: 1039-1047 (2007). *

• Bekeredjian-Ding I, Schafer M, Hartmann E, Pries R, Parcina M, Schneider P, Giese T, Endres S, Wollenberg B, Hartmann G. Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology 128: 439-450 (2009). *

• Belaguli NS, Zhang M, Rigi M, Aftab M, Berger DH. Cooperation between GATA4 and TGF-beta signaling regulates intestinal epithelial gene expression. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1520-G1533 (2007). *

• Bellinghausen I, Konig B, Bottcher I, Knop J, Saloga J. Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-beta for their induction. Clin. Exp. Allergy 36: 1546-1555 (2006). *

• Ben-David H, Sharabi A, Dayan M, Sela M, Mozes E. The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc. Natl. Acad. Sci. U.S.A. 104: 17459-17464 (2007). *

• Ben-David H, Sharabi A, Parameswaran R, Zinger H, Mozes E. A tolerogenic peptide down-regulates mature B cells in bone marrow of lupus-afflicted mice by inhibition of interleukin-7, leading to apoptosis. Immunology 128: 245-252 (2009). *

• Benahmed MB, Meresse B, Arnulf B, Barbe U, Mention JJ, Verkarre V, Allez M, Cellier C, Hermine O, Cerf-Bensussan N. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 132: 994-1008 (2007). *

• Bendicho MT, Guedes JC, Silva NN, Santana GO, dos Santos RR, Lyra AC, Lyra LG, Meyer R, Lemaire DC. Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. Pancreas 30: 333-336 (2005).

• Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204: 1765-1774 (2007). *

• Benwell RK, Lee DR. Essential and synergistic roles of IL1 and IL6 in human Th17 differentiation directed by TLR ligand-activated dendritic cells. Clin. Immunol. Oct 22 [Epub ahead of print] (2009). *

• Bergin DA, Greene CM, Sterchi EE, Kenna C, Geraghty P, Taggart CC, O'Neill SJ, McElvaney NG. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J. Biol. Chem. 283: 31736-31744 (2008). *

• Bergmann C, Strauss L, Zeidler R, Lang S, Whiteside TL. Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment. Cancer Immunol. Immunother. 56: 1429-1442 (2007). *

• Berhanu A, Huang J, Watkins SC, Okada H, Storkus WJ. Treatment-enhanced CD4+Foxp3+ glucocorticoid-induced TNF receptor family related regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy. J. Immunol. 178: 3400-3408 (2007). *

• Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17 producing human peripheral regulatory T cells retain suppressive function. Blood 113: 4240-4249 (2009). *

• Berndt SI, Huang WY, Chatterjee N, Yeager M, Welch R, Chanock SJ, Weissfeld JL, Schoen RE, Hayes RB. Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma. Carcinogenesis 28: 1965-1970 (2007). *

• Berro M, Mayor NP, Maldonado-Torres H, Cooke L, Kusminsky G, Marsh SG, Madrigal AA, Shaw BE. Association of functional polymorphisms of the transforming growth factor B1 gene with survival and graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation. Haematologica Aug 27 [Epub ahead of print] (2009). *

• Bessa J, Jegerlehner A, Hinton HJ, Pumpens P, Saudan P, Schneider P, Bachmann MF. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J. Immunol. 183: 3788-3799 (2009).

• Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238 (2006). *

• Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 19: 652-657 (2007). *

• Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8: 345-350 (2007). *

• Bettini M, Vignali DA. Regulatory T cells and inhibitory cytokines in autoimmunity. Curr. Opin. Immunol. 21: 612-618 (2009).

• Bhagat G, Naiyer AJ, Shah JG, Harper J, Jabri B, Wang TC, Green PH, Manavalan JS. Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J. Clin. Invest. 118: 281-293 (2008). *

• Bhan AK, Mizoguchi E, Smith RN, Mizoguchi A. Lessons for human inflammatory bowel disease from experimental models. Curr. Opin. Gastroenterol. 15: 285-290 (1999).

• Bhowmick S, Singh A, Flavell RA, B Clark R, Rourke JO, Cone RE. The sympathetic nervous system modulates CD4+FoxP3+ regulatory T cells via a TGF-beta-dependent mechanism. J. Leukoc. Biol. 86: 1275-1283 (2009). *

• Biasi F, Mascia C, Poli G. TGFbeta1 expression in colonic mucosa: modulation by dietary lipids. Genes Nutr. 2: 233-243 (2007). *

• Biburger M, Tiegs G. Chapter 23. Animal models of autoimmune liver diseases. In "Liver Immunology: Principles and Practice" (eds. Gershwin ME, Vierling JM, Manns MP), Humana Press Inc., Totowa, NJ, p. 293-306 (2007). *

• Bilate AM, Salemi VM, Ramires FJ, de Brito T, Russo M, Fonseca SG, Fae KC, Martins DG, Silva AM, Mady C, Kalil J, Cunha-Neto E. TNF blockade aggravates experimental chronic Chagas disease cardiomyopathy. Microbes Infect. 9: 1104-1113 (2007). *

• Bilodeau M, Tousignant J, Ethier C, Rocheleau B, Raymond VA, Lapointe R. Anti-apoptotic effect of insulin on normal hepatocytes in vitro and in vivo. Apoptosis 9: 609-617 (2004).

• Biros E, Clancy P, Norman PE, Golledge J. A genetic polymorphism in transforming growth factor beta receptor-2 is associated with serum osteopontin. Int. J. Immunogenet. 36: 241-244 (2009). *

• Bitzer M, von Gersdorff G, Liang D, Dominguez-Rosales A, Beg AA, Rojkind M, Bottinger EP. A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA. Genes Dev. 14: 187-197 (2000). *

• Bjornsson E. Immunoglobulin G4-associated cholangitis. Curr. Opin. Gastroenterol. 24: 389-394 (2008).

• Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J. Hepatol. 40: 942-951 (2004). *

• Black JA, Liu S, Waxman SG. Sodium channel activity modulates multiple functions in microglia. Glia 57: 1072-1081 (2009). *

• Black KE, Murray JA, David CS. HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J. Immunol. 169: 5595-600 (2002). *

• Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity Jan 13 [Epub ahead of print] (2010).

• Blauvelt A. New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-B1. Exp. Rev. Dermatol. 2: 69-78 (2007). *

• Bleich A, Janus LM, Smoczek A, Westendorf AM, Strauch U, Mahler M, Hedrich HJ, Fichtner-Feigl S, Scholmerich JU, Falk W, Hofmann C, Obermeier F. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136: 278-287 (2009). *

• Blewis ME, Lao BJ, Schumacher BL, Bugbee WD, Sah RL, Firestein GS. Interactive cytokine regulation of synoviocyte lubricant secretion. Tissue Eng. Part A. Nov 12 [Epub ahead of print] (2009).

• Bluestone JA. A balanced attack. The Scientist May, 2007 (http://www.the-scientist.com/2007/05/01/s32/1/ ) (2007).

• Blum A, Setiawan T, Hang L, Stoyanoff K, Weinstock JV. Interleukin-12 (IL-12) and IL23 induction of substance P synthesis in murine T cells and macrophages is subject to IL10 and TGFbeta regulation. Infect. Immun. 76: 3651-3656 (2008). *

• Blum R, Gupta R, Burger PE, Ontiveros CS, Salm SN, Xiong X, Kamb A, Wesche H, Marshall L, Cutler G, Wang X, Zavadil J, Moscatelli D, Wilson EL. Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. PLoS ONE 4: e5722 (2009). *

• Bockelmann R, Horn T, Gollnick H, Bonnekoh B. Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects. Skin Pharmacol. Physiol. 18: 42-54 (2005).

• Bogunovic M, Dave SH, Tilstra JS, Chang DT, Harpaz N, Xiong H, Mayer LF, Plevy SE. Enteroendocrine cells express functional Toll-like receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1770-G1783 (2007). *

• Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A, Palmieri G, Sanchez M, Strober W, Macdonald TT, Monteleone G. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 131: 1786-1798 (2006). *

• Boirivant M, Strober W, Fuss IJ. Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten. Inflamm. Bowel Dis. 11: 48-55 (2005). *

• Bollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, Evanko SP, Buckner JH, Wight TN, Nepom GT. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J. Immunol. 183: 2232-2241 (2009).

• Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, Doetschman T. Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. Clin. Exp. Immunol. 158: 317-324 (2009). *

• Bommireddy R, Doetschman T. TGFbeta1 and T(reg) cells: alliance for tolerance. Trends Mol. Med. 13: 492-501 (2007). *

• Bommireddy R, Pathak LJ, Martin J, Ormsby I, Engle SJ, Boivin GP, Babcock GF, Eriksson AU, Singh RR, Doetschman T. Self-antigen recognition by TGFbeta1-deficient T cells causes their activation and systemic inflammation. Lab. Invest. 86: 1008-1019 (2006). *

• Bonafe M, Olivieri F. Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. Mol. Cell. Endocrinol. 299: 118-123 (2009).

• Boomershine CS, Chamberlin A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson W, Thomas JW, Blackwell TS, Bhowmick NA. Autoimmune pancreatitis results from loss of TGF-beta signaling in S100A4-positive dendritic cells. Gut 58: 1267-1274 (2009). *

• Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung exacerbating acute inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L586-L595 (2009). *

• Borsutzky S, Cazac BB, Roes J, Guzman CA. TGF-beta receptor signaling is critical for mucosal IgA responses. J. Immunol. 173: 3305-3309 (2004). *

• Bosse Y, Rola-Pleszczynski M. Controversy surrounding the increased expression of TGFbeta1 in asthma. Respir. Res. 8: 66 (2007). *

• Boudousquie C, Pellaton C, Barbier N, Spertini F. CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma. Clin. Exp. Allergy 39: 1415-1426 (2009). *

• Bourikas LA, Kolios G, Valatas V, Notas G, Drygiannakis I, Pelagiadis I, Manousou P, Klironomos S, Mouzas IA, Kouroumalis E. Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br. J. Pharmacol. 157: 362-370 (2009). *

• Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumie A. Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation 117: 806-815 (2008). *

• Bournia VK, Vlachoyiannopoulos PG, Selmi C, Moutsopoulos HM, Gershwin ME. Recent advances in the treatment of systemic sclerosis. Clin. Rev. Allergy Immunol. 36: 176-200 (2009). *

• Bozza S, Zelante T, Moretti S, Bonifazi P, Deluca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L. Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J. Immunol. 180: 4022-4031 (2008). *

• Braat H, McGuirk P, Kate FT, Huibregtse I, Dunne P, Hommes D, Deventer S, Mills K. Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule. Gut 56: 351-357 (2007). *

• Brabcova I, Petrasek J, Hribova P, Hyklova K, Bartosova K, Lacha J, Viklicky O. Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation. Transplantation 84: 1037-1044 (2007).

• Bramlage CP, Kaps C, Ungethum U, Bramlage P, Koziolek M, Wessels J, Krenn V, Pruss A, Muller GA, Strutz F, Burmester GR, Haupl T. Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium. Scand. J. Rheumatol. 37: 401-409 (2008). *

• Brand S. Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease. Gut 58: 1152-1167 (2009).

• Bravo MJ, Colmenero JD, Queipo-Ortuno MI, Alonso A, Caballero A. TGF-beta1 and IL-6 gene polymorphism in Spanish brucellosis patients. Cytokine 44: 18-21 (2008).

• Brazova J, Sismova K, Vavrova V, Bartosova J, Macek M Jr, Lauschman H, Sediva A. Polymorphisms of TGF-beta1 in cystic fibrosis patients. Clin. Immunol. 121: 350-357 (2006). *

• Breen EC, Ignotz RA, McCabe L, Stein JL, Stein GS, Lian JB. TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype. J. Cell. Physiol. 160: 323-335 (1994).

• Bregenholt S, Delbro D, Claesson MH. T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease. APMIS 105: 655-662 (1997).

• Breitkopf K, Sawitza I, Westhoff JH, Wickert L, Dooley S, Gressner AM. Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells. Gut 54: 673-681 (2005). *

• Breivik T, Gundersen Y, Gjermo P, von Horsten S, Opstad PK. Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. J. Periodontal Res. 44: 110-116 (2009).

• Bremer LA, Blackman SM, Vanscoy LL, McDougal KE, Bowers A, Naughton KM, Cutler DJ, Cutting GR. Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis. Hum. Mol. Genet. 17: 2228-2237 (2008). *

• Brenmoehl J, Falk W, Goke M, Scholmerich J, Rogler G. Inflammation modulates fibronectin isoform expression in colonic lamina propria fibroblasts (CLPF). Int. J. Colorectal Dis. 23: 947-955 (2008). *

• Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Scholmerich J, Rogler G. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J. Gastroenterol. 15: 1431-1442 (2009). *

• Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y. Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc. Natl. Acad. Sci. U.S.A. 101: 16016-16021 (2004). *

• Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest. 116: 1371-1381 (2006). *

• Brezzi B, Del Prete D, Lupo A, Magistroni R, Gomez-Lira M, Bernich P, Anglani F, Mezzabotta F, Turco A, Furci L, Ceol M, Antonucci F, Abaterusso C, Bonfante L, D'Angelo A, Albertazzi A, Gambaro G. Primary IgA nephropathy is more severe in TGF-ss1 high secretor patients. J. Nephrol. 22: 747-759 (2009).

• Bridle KR, Popa C, Morgan ML, Sobbe AL, Clouston AD, Fletcher LM, Crawford DH. Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways. Liver Transpl. 15: 1315-1324 (2009). *

• Brigstock DR. Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): from pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J. Cell Commun. Signal. 3: 5-18 (2009). *

• Broderick P, Carvajal-Carmona L, Pittman AM, Webb E, Howarth K, Rowan A, Lubbe S, Spain S, Sullivan K, Fielding S, Jaeger E, Vijayakrishnan J, Kemp Z, Gorman M, Chandler I, Papaemmanuil E, Penegar S, Wood W, Sellick G, Qureshi M, Teixeira A, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat. Genet. 39: 1315-1317 (2007). *

• Broere F, Wieten L, Klein Koerkamp EI, van Roon JA, Guichelaar T, Lafeber FP, van Eden W. Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes. J. Immunol. 181: 899-906 (2008). *

• Brosens LA, van Hattem WA, Kools MC, Ezendam C, Morsink FH, de Leng WW, Giardiello FM, Offerhaus GJ. No TGFBRII germline mutations in juvenile polyposis patients without SMAD4 or BMPR1A mutation. Gut 58: 154-156 (2009).

• Brown DA, Moore J, Johnen H, Smeets TJ, Bauskin AR, Kuffner T, Weedon H, Milliken ST, Tak PP, Smith MD, Breit SN. Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction. Arthritis Rheum. 56: 753-764 (2007). *

• Brown JB, Lee G, Grimm GR, Barrett TA. Therapeutic benefit of pentostatin in severe IL-10(-/-) colitis. Inflamm. Bowel Dis. 14: 880-887 (2008). *

• Bruck R, Ashkenazi M, Weiss S, Goldiner I, Shapiro H, Aeed H, Genina O, Helpern Z, Pines M. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 27: 373-383 (2007). *

• Bruck R, Weiss S, Aeed H, Pines M, Halpern Z, Zvibel I. Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig. Dis. Sci. 54: 292-299 (2009). *

• Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 54: 3395-3401 (2005). *

• Brugman S, Visser JT, Hillebrands JL, Bos NA, Rozing J. Prolonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone rats. Diabetes Metab. Res. Rev. 25: 380-387 (2009).

• Brun P, Castagliuolo I, Pinzani M, Palu G, Martines D. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G571-G578 (2005). *

• Brun P, Mastrotto C, Beggiao E, Stefani A, Barzon L, Sturniolo GC, Palu G, Castagliuolo I. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G621-G629 (2005). *

• Brun V, Bastian H, Foussat A. Clinical grade production of IL-10 producing regulatory Tr1 lymphocytes for cell therapy of chronic inflammatory diseases. Int. Immunopharmacol. 9: 609-613 (2009).

• Bu S, Kapanadze B, Hsu T, Trojanowska M. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on TGFbeta/Smad pathway are mediated through the PTEN/PPM1A dependent pathway. J. Biol. Chem. 283: 19593-19602 (2008). *

• Budak F, Goral G, Heper Y, Yilmaz E, Aymak F, Basturk B, Tore O, Ener B, Oral HB. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis. Cytokine 38: 32-36 (2007).

• Buenafe AC, Bourdette DN. Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 182: 32-40 (2007).

• Bullard DC, Hu X, Adams JE, Schoeb TR, Barnum SR. p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis. Am. J. Pathol. 170: 2001-2008 (2007). *

• Bulut K, Pennartz C, Felderbauer P, Ansorge N, Banasch M, Schmitz F, Schmidt WE, Hoffmann P. Vascular endothelial growth factor (VEGF(164)) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-beta release from epithelial cells. Scand. J. Gastroenterol. 41: 687-692 (2006). *

• Buning C, Schmidt HH, Molnar T, DE Jong DJ, Fiedler T, Buhner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Drenth JP, Landt O, Nickel R, Buttner J, Lochs H, Witt H. Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. Aliment. Pharmacol. Ther. 26: 1025-1033 (2007). *

• Buraczynska M, Baranowicz-Gaszczyk I, Borowicz E, Ksiazek A. TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes. Nephron. Physiol. 106: 69-75 (2007).

• Buranawuti K, Boyle MP, Cheng S, Steiner LL, McDougal K, Fallin MD, Merlo C, Zeitlin PL, Rosenstein BJ, Mogayzel PJ Jr, Wang X, Cutting GR. Variants in mannose-binding lectin and tumor necrosis factor alpha affect survival in cystic fibrosis. J. Med. Genet. 44: 209-214 (2007). *

• Burgel PR, Montani D, Danel C, Dusser D, Nadel JA. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax 62: 153-161 (2007). *

• Burgler S, Ouaked N, Bassin C, Basinski TM, Mantel PY, Siegmund K, Meyer N, Akdis CA, Schmidt-Weber CB. Differentiation and functional analysis of human T(H)17 cells. J. Allergy Clin. Immunol. 123: 588-595, 595.e1-e7 (2009).

• Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, O'Connell PR. Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease. Inflamm. Bowel Dis. 14: 1197-1204 (2008). *

• Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, O'Connell PR. Fibrogenesis in Crohn's disease. Am. J. Gastroenterol. 102: 439-448 (2007). *

• Butler M, Ng CY, van Heel DA, Lombardi G, Lechler R, Playford RJ, Ghosh S. Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium. Eur. J. Immunol. 36: 864-874 (2006). *

• Buyon JP, Clancy RM, Friedman DM. Autoimmune associated congenital heart block: integration of clinical and research clues in the management of the maternal/foetal dyad at risk. J. Intern. Med. 265: 653-662 (2009). *

• Bynoe MS, Viret C. Foxp3(+)CD4(+) T cell-mediated immunosuppression involves extracellular nucleotide catabolism. Trends Immunol. 29: 99-102 (2008). *

• Cabbage SE, Huseby ES, Sather BD, Brabb T, Liggitt D, Goverman J. Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance. J. Immunol. 178: 887-896 (2007). *

• Cabre E, Gassull MA. Nutrition in inflammatory bowel disease: impact on disease and therapy. Curr. Opin. Gastroenterol. 17: 342-349 (2001).

• Cadoret A, Rey C, Wendum D, Elriz K, Tronche F, Holzenberger M, Housset C. IGF-1R contributes to stress-induced hepatocellular damage in experimental cholestasis. Am. J. Pathol. 175: 627-635 (2009). *

• Cai G, Cole SA, Butte NF, Smith CW, Mehta NR, Voruganti VS, Proffitt JM, Comuzzie AG. A genetic contribution to circulating cytokines and obesity in children. Cytokine 44: 242-247 (2008).

• Cai Q, Du X, Zhou B, Cai C, Kermany MH, Yoo T. Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. ORL J. Otorhinolaryngol. Relat. Spec. 71: 135-141 (2009).

• Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cell. Mol. Immunol. 7: 35-43 (2010). *

• Calcagni E, Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann. N. Y. Acad. Sci. 1069: 62-76 (2006). *

• Calderon B, Suri A, Pan XO, Mills JC, Unanue ER. IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes. J. Immunol. 181: 6964-6974 (2008). *

• Calura E, Cagnin S, Raffaello A, Laveder P, Lanfranchi G, Romualdi C. Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages. BMC Genomics 9: 630 (2008). *

• Calvisi DF, Ladu S, Hironaka K, Factor VM, Thorgeirsson SS. Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer. J. Hepatol. 41: 815-822 (2004). *

• Calvisi DF, Simile MM, Ladu S, Pellegrino R, De Murtas V, Pinna F, Tomasi ML, Frau M, Virdis P, De Miglio MR, Muroni MR, Pascale RM, Feo F. Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis. Int. J. Cancer 121: 2410-2420 (2007). *

• Camelo S, Lajavardi L, Bochot A, Goldenberg B, Naud MC, Brunel N, Lescure B, Klein C, Fattal E, Behar-Cohen F, de Kozak Y. Protective effect of intravitreal injection of vasoactive intestinal peptide (VIP)-loaded liposomes on experimental autoimmune uveoretinitis. J. Ocul. Pharmacol. Ther. 25: 9-21 (2009).

• Cameron RG, Blendis LM, Neuman MG. Accumulation of macrophages in primary sclerosing cholangitis. Clin. Biochem. 34: 195-201 (2001). *

• Campbell JD, Cook G, Robertson SE, Fraser A, Boyd KS, Gracie JA, Franklin IM. Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15. J. Immunol. 167: 553-561 (2001). *

• Campbell JS, Hughes SD, Gilbertson DG, Palmer TE, Holdren MS, Haran AC, Odell MM, Bauer RL, Ren HP, Haugen HS, Yeh MM, Fausto N. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 102: 3389-3394 (2005). *

• Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J. AIDS progression is associated with the emergence of IL-17-producing cells early after Simian immunodeficiency virus infection. J. Immunol. 184: 984-992 (2010).

• Campos Alberto EJ, Shimojo N, Suzuki Y, Mashimo Y, Arima T, Matsuura T, Inoue Y, Yamaide A, Tomiita M, Fujii K, Hata A, Kohno Y. IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population. Pediatr. Allergy Immunol. 19: 716-721 (2008).

• Campos PP, Bakhle YS, Andrade SP. Mechanisms of wound healing responses in lupus-prone New Zealand White mouse strain. Wound Repair Regen. 16: 416-424 (2008). *

• Canbakan B, Akin H, Tahan G, Tarcin O, Eren F, Atug O, Tahan V, Imeryuz N, Yapicier O, Avsar E, Tozun N. The effects of pegylated interferon alpha 2b on bile-duct ligation induced liver fibrosis in rats. Ann. Hepatol. 8: 234-240 (2009).

• Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J. Pharmacol. Exp. Ther. 308: 1191-1196 (2004). *

• Cano DA, Sekine S, Hebrok M. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131: 1856-1869 (2006). *

• Cantor MJ, Nickerson P, Bernstein CN. The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. Am. J. Gastroenterol. 100: 1134-1142 (2005). *

• Cantorna MT, Woodward WD, Hayes CE, DeLuca HF. 1,25-Dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J. Immunol. 160: 5314-5319 (1998). *

• Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4+CD25- T cells and T regulatory cells. J. Biol. Chem. 284: 24914-24924 (2009). *

• Caprioli F, Pallone F, Monteleone G. Th17 immune response in IBD: a new pathogenic mechanism. Journal of Crohn's and Colitis 2: 291-295 (2008).

• Capron A, Dombrowicz D, Capron M. Helminth infections and allergic diseases: from the Th2 paradigm to regulatory networks. Clin. Rev. Allergy Immunol. 26: 25-34 (2004). *

• Carambia A, Herkel J. CD4 T cells in hepatic immune tolerance. J. Autoimmun. Aug 29 [Epub ahead of print] (2009).

• Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Junior WM, Rossi MA, Silva JS. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol. Immunol. 24: 1-6 (2009). *

• Cardoso CR, Provinciatto PR, Godoi DF, Vieira TS, Ferreira BR, Teixeira G, Rossi MA, Cunha FQ, Silva JS. B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy. Clin. Exp. Immunol. 154: 153-161 (2008). *

• Carethers JM. Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis. Gastroenterology 137: 33-36 (2009). *

• Carrero JJ, Park SH, Axelsson J, Lindholm B, Stenvinkel P. Cytokines, atherogenesis, and hypercatabolism in chronic kidney disease: a dreadful triad. Semin. Dial. 22: 381-386 (2009).

• Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J. Immunol. 178: 172-178 (2007). *

• Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J. Immunol. 178: 179-185 (2007). *

• Caserta TM, Knisley AA, Tan FK, Arnett FC, Brown TL. Genotypic analysis of the TGF beta-509 allele in patients with systemic lupus erythematosus and Sjogren's syndrome. Ann. Genet. 47: 359-363 (2004).

• Casetti R, Agrati C, Wallace M, Sacchi A, Martini F, Martino A, Rinaldi A, Malkovsky M. Cutting edge: TGF-beta1 and IL-15 induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulation. J. Immunol. 183: 3574-3577 (2009).

• Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum. Mol. Genet. Nov 20 [Epub ahead of print] (2009).

• Castellanos-Rubio A, Santin I, Irastorza I, Castano L, Carlos Vitoria J, Ramon Bilbao J. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 42: 69-73 (2009).

• Castillejo A, Rothman N, Murta-Nascimento C, Malats N, Garcia-Closas M, Gomez-Martinez A, Lloreta J, Tardon A, Serra C, Garcia-Closas R, Chanock S, Silverman DT, Dosemeci M, Kogevinas M, Carrato A, Soto JL, Real FX. TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis. Int. J. Cancer 124: 608-613 (2008). *

• Castro RE, Sola S, Ma X, Ramalho RM, Kren BT, Steer CJ, Rodrigues CM. A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. J. Hepatol. 42: 897-906 (2005). *

• Cavaillon JM, Adib-Conquy M. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit. Care 10: 233 (2006). *

• Cavassani KA, Campanelli AP, Moreira AP, Vancim JO, Vitali LH, Mamede RC, Martinez R, Silva JS. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J. Immunol. 177: 5811-5818 (2006). *

• Cawthorn TR, Amir E, Broom R, Freedman O, Gianfelice D, Barth D, Wang D, Holen I, Done SJ, Clemons M. Mechanisms and pathways of bone metastasis: challenges and pitfalls of performing molecular research on patient samples. Clin. Exp. Metastasis 26: 935-943 (2009).

• Cayon A, Crespo J, Guerra AR, Pons-Romero F. Gene expression in obese patients with non-alcoholic steatohepatitis. Rev. Esp. Enferm. Dig. 100: 212-218 (2008).

• Cha DR, Zhang X, Zhang Y, Wu J, Su DM, Han JY, Fang X, Yu B, Breyer MD, Guan Y. Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice. Diabetes 56: 2036-2045 (2007). *

• Chai JG, Coe D, Chen D, Simpson E, Dyson J, Scott D. In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J. Immunol. 180: 858-869 (2008). *

• Chai SK, Altman GM, Yazdanbakhsh M, Tsuji J, Godat L, Takaro TK. Production of interleukin 10 and transforming growth factor beta in concomitant allergy and autoimmunity. Ann. Allergy Asthma Immunol. 94: 279-285 (2005).

• Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 20: 334-345 (2009).

• Chan CC, Reed GF, Kim Y, Agron E, Buggage RR. A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis. Br. J. Ophthalmol. 88: 1506-1509 (2004). *

• Chan LY, Leung JC, Tsang AW, Tang SC, Lai KN. Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy. Kidney Int. 67: 602-612 (2005). *

• Chan RW, Lai FM, Li EK, Tam LS, Chow KM, Lai KB, Li PK, Szeto CC. Intra-renal cytokine gene expression in lupus nephritis. Ann. Rheum. Dis. 66: 886-892 (2007). *

• Chanda D, Lee CH, Kim YH, Noh JR, Kim DK, Park JH, Hwang JH, Lee MR, Jeong KH, Lee IK, Kweon GR, Shong M, Oh GT, Chiang JY, Choi HS. Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner. Hepatology 50: 880-892 (2009).

• Chang HJ, Lee JH, Hwang KJ, Kim MR, Chang KH, Park DW, Min CK. Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator … Fertil. Steril. 90: S1357-S1365 (2008).

• Chang JH, Kim YJ, Han SH, Kang CY. IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis. Eur. J. Immunol. 39: 1241-1251 (2009). *

• Chang SH, Park H, Dong C. Act1 adaptor protein is an immediate and essential signaling component of IL-17 receptor. J. Biol. Chem. 281: 35603-35607 (2006). *

• Chang SJ, Chen CJ, Tsai FC, Lai HM, Tsai PC, Tsai MH, Ko YC. Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor beta1 gene. Rheumatology (Oxford) 47: 617-621 (2008). *

• Chang WW, Su H, He L, Zhao KF, Wu JL, Xu ZW. Association between transforming growth factor-beta1 T869C polymorphism and rheumatoid arthritis: a meta-analysis. Rheumatology (Oxford) Jan 4 [Epub ahead of print] (2010).

• Chang Y, Jiang HJ, Sun XM, Cai XK, He XX, Li PY, Tang WX, Song YH, Lin JS. Hepatic stellate cell-specific gene silencing induced by an artificial microRNA for antifibrosis in vitro. Dig. Dis. Sci. Nov 5 [Epub ahead of print] (2009). *

• Chao CC, Janoff EN, Hu SX, Thomas K, Gallagher M, Tsang M, Peterson PK. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 3: 292-298 (1991).

• Chaput N, Louafi S, Bardier A, Charlotte F, Vaillant JC, Menegaux F, Rosenzwajg M, Lemoine F, Klatzmann D, Taieb J. Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue. Gut 58: 520-529 (2009).

• Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson RG, Kollias G, Smyth JF, Balkwill FR, Hagemann T. The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J. Clin. Invest. 119: 3011-3023 (2009). *

• Charlton M, Viker K, Krishnan A, Sanderson S, Veldt B, Kaalsbeek AJ, Kendrick M, Thompson G, Que F, Swain J, Sarr M. Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. Hepatology 49: 1375-1384 (2009).

• Charng MJ, Wu CH. Transcriptional activation of p21 by Tranilast is mediated via transforming growth factor beta signal pathway. Br. J. Pharmacol. 147: 117-124 (2006). *

• Chatenoud L. CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol. 3: 123-132 (2003).

• Chatenoud L. CD3-specific antibodies restore self-tolerance: mechanisms and clinical applications. Curr. Opin. Immunol. 17: 632-637 (2005).

• Chatila TA. Molecular mechanisms of regulatory T-cell development. Chem. Immunol. Allergy 94: 16-28 (2008).

• Chaturvedi P, Singh AP, Batra SK. Structure, evolution, and biology of the MUC4 mucin. FASEB J. 22: 966-981 (2008). *

• Chea SW, Lee KB. TGF-beta mediated epithelial-mesenchymal transition in autosomal dominant polycystic kidney disease. Yonsei Med. J. 50: 105-111 (2009). *

• Chedid A, Mendenhall CL, Moritz TE. The antigenic heterogeneity of the bile duct epithelium in alcoholic liver disease. VA Cooperative Study Group 275. Arch. Pathol. Lab. Med. 123: 411-414 (1999). *

• Chegini N. TGF-beta system: the principal profibrotic mediator of peritoneal adhesion formation. Semin. Reprod. Med. 26: 298-312 (2008).

• Chen A, Zheng S. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br. J. Pharmacol. 153: 557-567 (2008). *

• Chen C, Zhang C, Zhuang G, Luo H, Su J, Yin P, Wang J. Decoy receptor 3 overexpression and immunologic tolerance in hepatocellular carcinoma (HCC) development. Cancer Invest. 26: 965-974 (2008).

• Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y. Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells. J. Leukoc. Biol. 83: 280-287 (2008). *

• Chen GG, Xu H, Lee JF, Subramaniam M, Leung KL, Wang SH, Chan UP, Spelsberg TC. 15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. Int. J. Cancer 107: 837-843 (2003). *

• Chen GQ, Chen YY, Wang XS, Wu SZ, Yang HM, Xu HQ, He JC, Wang XT, Chen JF, Zheng RY. Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats. Brain Res. 1309: 116-125 (2010).

• Chen H, He YW, Liu WQ, Zhang JH. Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum. World J. Gastroenterol. 14: 2905-2911 (2008). *

• Chen H, Qin J, Wei P, Zhang J, Li Q, Fu L, Li S, Ma C, Cong B. Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells. Prostaglandins Leukot. Essent. Fatty Acids 80: 195-200 (2009). *

• Chen H, Wang W, Xie H, Xu X, Wu J, Jiang Z, Zhang M, Zhou L, Zheng S. A pathogenic role of IL-17 at the early stage of corneal allograft rejection. Transpl. Immunol. 21: 155-161 (2009).

• Chen J, Liu XS. Development and function of IL-10 IFN-gamma-secreting CD4+ T cells. J. Leukoc. Biol. 86: 1305-1310 (2009). *

• Chen L, Liu BC, Zhang XL, Zhang JD, Liu H, Li MX. Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells. Acta Pharmacol. Sin. 27: 1029-1036 (2006). *

• Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J. Immunol. 180: 7327-7337 (2008). *

• Chen ML, Yan BS, Kozoriz D, Weiner HL. Novel CD8(+) regulatory T cells suppress experimental autoimmune encephalomyelitis by TGF-beta- and IFN-gamma-dependent mechanisms. Eur. J. Immunol. 39: 3423-3435 (2009). *

• Chen W, Herold KC, Bluestone JA. Achieving antigen-specific tolerance in diabetes: regulating specifically. Int. Rev. Immunol. 24: 287-305 (2005).

• Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886 (2003). *

• Chen W, Li YM, Yu MH. Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice. Exp. Clin. Endocrinol. Diabetes 116: 468-474 (2008).

• Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL. Defective functions of circulating CD4(+)CD25(+) and CD4(+)CD25(-) T cells in patients with chronic ordinary urticaria. J. Dermatol. Sci. 51: 121-130 (2008).

• Chen WY, Chen CJ, Liao JW, Mao FC. Chromium attenuates hepatic damage in a rat model of chronic cholestasis. Life Sci. 84: 606-614 (2009).

• Chen X, Zhang M, Liao M, Graner MW, Wu C, Yang Q, Liu H, Zhou B. Reduced Th17 response in patients with tuberculosis correlate with IL-6R expression on CD4+ T cells. Am. J. Respir. Crit. Care Med. Dec 17 [Epub ahead of print] (2009). *

• Chen XL, Ciren SZ, Zhang H, Duan LG, Wesley AJ. Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis. World J. Gastroenterol. 15: 2032-2037 (2009). *

• Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA Jr, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc. Natl. Acad. Sci. U.S.A. 93: 388-391 (1996). *

• Chen Y, Kam CS, Liu FQ, Liu Y, Lui VC, Lamb JR, Tam PK. LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages. J. Leukoc. Biol. 83: 1165-1173 (2008). *

• Chen Z, Laurence A, O'Shea JJ. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 19: 400-408 (2007). *

• Chen Z, O'Shea JJ. Th17 cells: a new fate for differentiating helper T cells. Immunol. Res. 41: 87-102 (2008). *

• Chen Z, O'Shea JJ. Regulation of IL-17 production in human lymphocytes. Cytokine 41: 71-78 (2008).

• Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56: 2936-2946 (2007). *

• Cheng K, Yang N, Mahato RI. TGF-1 gene silencing for treating liver fibrosis. Mol. Pharm. 6: 772-779 (2009). *

• Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, Yao R, Chen Y, Liao YH. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin. Immunol. 127: 89-97 (2008). *

• Cheng Y, Ping J, Xu LM. Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. Chin. Med. J. (Engl.) 120: 794-801 (2007).

• Cheung RS, Brooling JT, Johnson MM, Riehle KJ, Campbell JS, Fausto N. Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells. Carcinogenesis 28: 2624-2631 (2007). *

• Chi CH, Liu IL, Lo WY, Liaw BS, Wang YS, Chi KH. Hepatocyte growth factor gene therapy prevents radiation-induced liver damage. World J. Gastroenterol. 11: 1496-1502 (2005). *

• Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS ONE 3: e1879 (2008). *

• Chin HJ, Fu YY, Ahn JM, Na KY, Kim YS, Kim S, Chae DW. Omacor(R), n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals. Nephrol. Dial. Transplant. Dec 29 [Epub ahead of print] (2009).

• Chiu YH, Hsieh YJ, Liao KW, Peng KC. Preferential promotion of apoptosis of monocytes by Lactobacillus casei rhamnosus soluble factors. Clin. Nutr. Aug 6 [Epub ahead of print] (2009).

• Cho J. Update on inflammatory bowel disease genetics. Curr. Gastroenterol. Rep. 2: 434-439 (2000).

• Cho JH, Huh S, Kwon TG, Choi JY, Hur IK, Lee EY, Park SH, Kim YL, Kim CD. Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with chronic allograft nephropathy and graft survival in Korean renal transplant recipients. Transplant. Proc. 40: 2355-2360 (2008). *

• Cho JW, Kim JY, Kim CW, Lee KS. Down-regulation of TGF-beta1-induced type I collagen synthesis by AP-1 transcription factor decoy in scleroderma fibroblasts. J. Dermatol. Sci. 43: 207-209 (2006).

• Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol. Lett. 105: 159-166 (2006).

• Choi BM, Pae HO, Jeong YR, Kim YM, Chung HT. Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression. Biochem. Biophys. Res. Commun. 327: 1066-1071 (2005). *

• Choi EK, Kim MH, Jang SJ, Lee KH, Hwang CY, Moon SH, Lee TY, Koh CO, Park DH, Lee SS, Seo DW, Lee SK. Differences in pancreatic immunohistochemical staining profiles of TGF-beta1, MMP-2, and TIMP-2 between autoimmune and alcoholic chronic pancreatitis. Pancreas 38: 739-745 (2009).

• Choi EW, Shin IS, Bhang DH, Lee DH, Bae BK, Kang MS, Kim DY, Hwang CY, Lee CW, Youn HY. Hormonal change and cytokine mRNA expression in peripheral blood mononuclear cells during the development of canine autoimmune thyroiditis. Clin. Exp. Immunol. 146: 101-108 (2006). *

• Choi JW, Um JY, Kundu JK, Surh YJ, Kim S. Multi-directional tumor suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Carcinogenesis 30: 1638-1644 (2009). *

• Choileain NN, Macconmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA. Enhanced regulatory T cell activity is an element of the host response to injury. J. Immunol. 176: 225-236 (2006). *

• Chotikavanich S, de Paiva CS, Li DQ, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest. Ophthalmol. Vis. Sci. 50: 3203-3209 (2009).

• Chow WL, Lee YK. Free fucose is a danger signal to human intestinal epithelial cells. Br. J. Nutr. 99: 449-454 (2008). *

• Chrobak P. Control of T cell responses, tolerance and autoimmunity by regulatory T cells: current concepts. Acta Medica (Hradec Kralove) 46: 131-137 (2003).

• Chromik AM, Muller AM, Albrecht M, Rottmann S, Otte JM, Herdegen T, Uhl W, Mittelkotter U. Oral administration of taurolidine ameliorates chronic DSS colitis in mice. J. Invest. Surg. 20: 273-282 (2007). *

• Chuang YH, Lian ZX, Yang GX, Shu SA, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B, Gershwin ME. Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology 47: 571-580 (2008). *

• Chung BS, Lee JK, Choi MH, Park MH, Choi D, Hong ST. Single nucleotide polymorphisms of cytokine genes are associated with fibrosis of the intrahepatic bile duct wall in human clonorchiasis. Korean J. Parasitol. 47: 145-151 (2009).

• Chung Y, Dong C. Don’t leave home without it: the IL-23 visa to TH-17 cells. Nat. Immunol. 10: 236-238 (2009). *

• Chung Y, Yang X, Chang SH, Ma L, Tian Q, Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16: 902-907 (2006). *

• Chung YW, Choi JH, Oh TY, Eun CS, Han DS. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin. Exp. Immunol. 151: 182-189 (2008). *

• Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr. Vasc. Pharmacol. 7: 330-337 (2009).

• Ciecierski R, Wisniewski M, Paczek L. Liver regeneration. Pol. Merkuriusz. Lek. 18: 473-477 (2005).

• Cihakova D, Barin JG, Afanasyeva M, Kimura M, Fairweather D, Berg M, Talor MV, Baldeviano GC, Frisancho S, Gabrielson K, Bedja D, Rose NR. Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. Am. J. Pathol. 172: 1195-1208 (2008). *

• Cinek O, Vavrincova P, Striz I, Drevinek P, Sedlakova P, Vavrinec J, Slavcev A. Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population. J. Rheumatol. 31: 1206-1210 (2004).

• Ciprandi G, De Amici M, Negrini S, Marseglia G, Tosca MA. TGF-beta and IL-17 serum levels and specific immunotherapy. Int. Immunopharmacol. 9: 1247-1249 (2009).

• Ciric B, El-Behi M, Cabrera R, Zhang GX, Rostami A. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J. Immunol. 182: 5296-5305 (2009).

• Clancy RM, Zheng P, O'Mahony M, Izmirly P, Zavadil J, Gardner L, Buyon JP. Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block. Arthritis Rheum. 56: 4120-4131 (2007). *

• Claria J, Horrillo R, Martinez-Clemente M, Moran-Salvador E, Titos E, Gonzalez-Periz A, Ferre N. Basic mechanisms of hepatocellular injury. Role of inflammatory lipid mediators. Gastroenterol. Hepatol. 31: 682-692 (2008).

• Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J. Exp. Med. 205: 2221-2234 (2008). *

• Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109: 194-202 (2007). *

• Classen S, Zander T, Eggle D, Chemnitz JM, Brors B, Buchmann I, Popov A, Beyer M, Eils R, Debey S, Schultze JL. Human resting CD4(+) T cells are constitutively inhibited by TGFbeta under steady-state conditions. J. Immunol. 178: 6931-6940 (2007). *

• Claudino M, Garlet TP, Cardoso CR, de Assis GF, Taga R, Cunha FQ, Silva JS, Garlet GP. Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice. Eur. J. Oral Sci. 118: 19-28 (2010).

• Clavel T, Haller D. Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. Inflamm. Bowel Dis. 13: 1153-1164 (2007). *

• Coban S, Yuksel O, Kockar MC, Koklu S, Basar O, Tutkak H, Ormeci N. The significance of serum transforming growth factor beta 1 in detecting of gastric and colon cancers. Hepatogastroenterology 54: 1472-1476 (2007).

• Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M. A role for Dicer in immune regulation. J. Exp. Med. 203: 2519-2527 (2006). *

• Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, Benagiano M, Paccani SR, Sambri V, Del Prete G, Baldari CT, Zanotti G, Montecucco C, D'Elios MM, de Bernard M. Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum. 58: 3609-3617 (2008). *

• Coffman RL, Lebman DA, Shrader B. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 1989. 170: 1039-1044. J. Immunol. 182: 8-13 (2009). *

• Coffman RL, Lebman DA, Shrader B. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170: 1039-1044 (1989). *

• Cohen Jr MM. The new bone biology: pathologic, molecular, and clinical correlates. Am. J. Med. Genet. A. 140: 2646-2706 (2006).

• Cohen Jr MM. Perspectives on RUNX genes: an update. Am. J. Med. Genet. A. 149A: 2629-2646 (2009).

• Cohly HH, Panja A. Immunological findings in autism. Int. Rev. Neurobiol. 71: 317-341 (2005).

• Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22: 789-815 (2004). *

• Colic M, Gazivoda D, Vucevic D, Vasilijic S, Rudolf R, Lukic A. Proinflammatory and immunoregulatory mechanisms in periapical lesions. Mol. Immunol. 47: 101-113 (2009). *

• Collaco JM, Vanscoy L, Bremer L, McDougal K, Blackman SM, Bowers A, Naughton K, Jennings J, Ellen J, Cutting GR. Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease. JAMA 299: 417-424 (2008). *

• Colleran G, McInerney N, Rowan A, Barclay E, Jones AM, Curran C, Miller N, Kerin M, Tomlinson I, Sawyer E. The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer. Breast Cancer Res. Treat. 119: 437-442 (2010).

• Comporti M, Arezzini B, Signorini C, Sgherri C, Monaco B, Gardi C. F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis? Lab. Invest. 85: 1381-1391 (2005). *

• Comporti M, Signorini C, Arezzini B, Vecchio D, Monaco B, Gardi C. Isoprostanes and hepatic fibrosis. Mol. Aspects Med. 29: 43-49 (2008).

• Conant SB, Swanborg RH. Autoreactive T cells persist in rats protected against experimental autoimmune encephalomyelitis and can be activated through stimulation of innate immunity. J. Immunol. 172: 5322-5328 (2004). *

• Cong Y, Feng T, Fujihashi K, Schoeb TR, Elson CO. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc. Natl. Acad. Sci. U.S.A. 106: 19256-19261 (2009). *

• Cong Y, Konrad A, Iqbal N, Hatton RD, Weaver CT, Elson CO. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J. Immunol. 174: 2787-2795 (2005). *

• Cong Y, Wang L, Konrad A, Schoeb T, Elson CO. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. Eur. J. Immunol. 39: 3134-3146 (2009). *

• Cong Y, Weaver CT, Lazenby A, Elson CO. Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J. Immunol. 169: 6112-6119 (2002). *

• Contractor N, Louten J, Kim L, Biron CA, Kelsall BL. Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype. J. Immunol. 179: 2690-2694 (2007). *

• Cooke A. Th17 cells in inflammatory conditions. Rev. Diabet. Stud. 3: 72-75 (2006). *

• Cools N, Ponsaerts P, Van Tendeloo VF, Berneman ZN. Regulatory T cells and human disease. Clin. Dev. Immunol. 2007: 89195 (2007). *

• Coombes JL, Robinson NJ, Maloy KJ, Uhlig HH, Powrie F. Regulatory T cells and intestinal homeostasis. Immunol. Rev. 204: 184-194 (2005). *

• Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta- and retinoic acid-dependent mechanism. J. Exp. Med. 204: 1757-1764 (2007). *

• Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180: 7097-7101 (2008). *

• Coral-Alvarado P, Quintana G, Garces MF, Cepeda LA, Caminos JE, Rondon F, Iglesias-Gamarra A, Restrepo JF. Potential biomarkers for detecting pulmonary arterial hypertension in patients with systemic sclerosis. Rheumatol. Int. 29: 1017-1024 (2009). *

• Coras R, Holsken A, Seufert S, Hauke J, Eyupoglu IY, Reichel M, Trankle C, Siebzehnrubl FA, Buslei R, Blumcke I, Hahnen E. The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion. Mol. Cancer Ther. 6: 1745-1754 (2007). *

• Correale J, Farez M. Association between parasite infection and immune responses in multiple sclerosis. Ann. Neurol. 61: 97-108 (2007).

• Correale J, Farez M. Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms. J. Immunol. 183: 5999-6012 (2009).

• Corvol H, Boelle PY, Brouard J, Knauer N, Chadelat K, Henrion-Caude A, Flamant C, Muselet-Charlier C, Boule M, Fauroux B, Vallet C, Feingold J, Ratjen F, Grasemann H, Clement A. Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis. Pediatr. Pulmonol. 43: 1224-1232 (2008).

• Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology 48: 276-288 (2008). *

• Costas Armada P, Garcia-Mayor RV, Larranaga A, Seguin P, Perez Mendez LF. Rate of undernutrition and response to specific nutritional therapy in Crohn's disease. Nutr. Hosp. 24: 161-166 (2009).

• Couchourel D, Aubry I, Delalandre A, Lavigne M, Martel-Pelletier J, Pelletier JP, Lajeunesse D. Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production. Arthritis Rheum. 60: 1438-1450 (2009). *

• Coulouarn C, Factor VM, Thorgeirsson SS. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 47: 2059-2067 (2008). *

• Couper KN, Blount DG, de Souza JB, Suffia I, Belkaid Y, Riley EM. Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. J. Immunol. 178: 4136-4146 (2007). *

• Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog. 4: e1000004 (2008). *

• Crilly A, Hamilton J, Clark CJ, Jardine A, Madhok R. Analysis of transforming growth factor beta1 gene polymorphisms in patients with systemic sclerosis. Ann. Rheum. Dis. 61: 678-681 (2002). *

• Crispin JC, Vargas MI, Alcocer-Varela J. Immunoregulatory T cells in autoimmunity. Autoimmun. Rev. 3: 45-51 (2004).

• Crivello A, Giacalone A, Vaglica M, Scola L, Forte GI, Macaluso MC, Raimondi C, Noto LD, Bongiovanni A, Accardo A, Candore G, Palmeri L, Verna R, Caruso C, Lio D, Palmeri S. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann. N. Y. Acad. Sci. 1089: 98-103 (2006). *

• Croxford AL, Kurschus FC, Waisman A. Cutting edge: an IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. J. Immunol. 182: 1237-1241 (2009).

• Cruickshank SM, McVay LD, Baumgart DC, Felsburg PJ, Carding SR. Colonic epithelial cell mediated suppression of CD4 T cell activation. Gut 53: 678-684 (2004). *

• Cruickshank SM, Southgate J, Selby PJ, Trejdosiewicz LK. Expression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established liver cell lines in vitro. J. Hepatol. 29: 550-558 (1998). *

• Csernok E, Szymkowiak CH, Mistry N, Daha MR, Gross WL, Kekow J. Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Clin. Exp. Immunol. 105: 104-111 (1996). *

• Cua DJ, Kastelein RA. TGF-beta, a 'double agent' in the immune pathology war. Nat. Immunol. 7: 557-559 (2006). *

• Cuadrado E, Alonso M, de Juan MD, Echaniz P, Arenas JI. Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis. World J. Gastroenterol. 14: 1521-1527 (2008). *

• Cubero FJ, Nieto N. Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. Hepatology 48: 2027-2039 (2008). *

• Cudrici C, Ito T, Zafranskaia E, Weerth S, Rus V, Chen H, Niculescu F, Soloviova K, Tegla C, Gherman A, Raine CS, Shin ML, Rus H. Complement C5 regulates the expression of insulin-like growth factor binding proteins in chronic experimental allergic encephalomyelitis. J. Neuroimmunol. 203: 94-103 (2008).

• Cui Y, Xiao Z, Shuxia W, Zhenjun Z, Hengguo Z, Liangyi F, Weicheng G, Li L, Guangfeng Z, Yunzhen S, Guangfu D. Computed tomography guided intra-articular injection of etanercept in the sacroiliac joint is an effective mode of treatment of ankylosing spondylitis. Scand. J. Rheumatol. Jan 28 [Epub ahead of print] (2010). *

• Curtis MM, Way SS, Wilson CB. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J. Immunol. 183: 381-387 (2009).

• Cutolo M, Soldano S, Montagna P, Sulli A, Seriolo B, Villaggio B, Triolo P, Clerico P, Felli L, Brizzolara R. CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production. Arthritis Res. Ther. 11: R176 (2009). *

• Cuvelier C, Mielants H, De Vos M, Quatacker J, Veys E. Idiopathic inflammatory bowel diseases: immunological hypothesis. Acta Gastroenterol. Belg. 57: 292-299 (1994).

• Czaja AJ. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: a foray across diagnostic boundaries. J. Hepatol. 44: 251-252 (2006). *

• Czaja AJ. Autoimmune liver disease and rheumatic manifestations. Curr. Opin. Rheumatol. 19: 74-80 (2007).

• Czaja AJ. Autoimmune liver disease. Curr. Opin. Gastroenterol. 20: 231-240 (2004).

• Czochra P, Klopcic B, Meyer E, Herkel J, Garcia-Lazaro JF, Thieringer F, Schirmacher P, Biesterfeld S, Galle PR, Lohse AW, Kanzler S. Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J. Hepatol. 45: 419-428 (2006). *

• da Silva AP, Ellen RP, Sorensen ES, Goldberg HA, Zohar R, Sodek J. Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice. Lab. Invest. 89: 1169-1181 (2009). *

• Daans M, Lories RJ, Luyten FP. Absence of GDF5 does not interfere with LPS Toll-like receptor signaling. Clin. Exp. Rheumatol. 27: 495-498 (2009).

• Dachrut S, Banthaisong S, Sripa M, Paeyao A, Ho C, Lee SA, Kosinski C, Patil MA, Zhang J, Chen X, Sripa B, Pairojkul C. DNA copy-number loss on 1p36.1 harboring RUNX3 with promoter hypermethylation and associated loss of RUNX3 expression in liver fluke-associated intrahepatic cholangiocarcinoma. Asian Pac. J. Cancer Prev. 10: 575-582 (2009).

• Dai CY, Chuang WL, Lee LP, Pan WC, Huang JF, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, Yu ML. Association between transforming growth factor-beta 1 polymorphism and virologic characteristics of chronic hepatitis C. Transl. Res. 152: 151-156 (2008). *

• Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V. Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J. Exp. Med. 206: 793-805 (2009). *

• Dairkee SH, Ji Y, Ben Y, Moore DH, Meng Z, Jeffrey SS. A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue. BMC Genomics 5: 47 (2004). *

• Daly AC, Vizan P, Hill CS. SMAD3 protein levels are modulated by ras activity and during cell cycle to dictate TGF-beta responses. J. Biol. Chem. Dec 26 [Epub ahead of print] (2009). *

• Dammeier J, Brauchle M, Falk W, Grotendorst GR, Werner S. Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease? Int. J. Biochem. Cell Biol. 30: 909-922 (1998). *

• Danda RS, Habiba NM, Rincon-Choles H, Bhandari BK, Barnes JL, Abboud HE, Pergola PE. Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int. 68: 2562-2571 (2005). *

• Danese S, de la Rue SA, Rutella S. Dendritic cells, TGF-beta, and integrin alpha(v)beta(8) in inflammatory bowel disease: a tolerogenic "ménage a trois" Gastroenterology 134: 354-355 (2008). *

• Daniel C, Sartory N, Zahn N, Geisslinger G, Radeke HH, Stein JM. FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. J. Immunol. 178: 2458-2468 (2007). *

• Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM. Immune modulatory treatment of TNBS colitis with calcitriol is associated with a change of a Th1/Th17 to a Th2 and regulatory T cell profile. J. Pharmacol. Exp. Ther. 324: 23-33 (2008). *

• Daniel C, Schroder O, Zahn N, Gaschott T, Steinhilber D, Stein JM. The TGFbeta/Smad 3-signaling pathway is involved in butyrate-mediated vitamin D receptor (VDR)-expression. J. Cell. Biochem. 102: 1420-1431 (2007). *

• Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK. IL-4 inhibits TGF-beta-induced Foxp3(+) T cells and, together with TGF-beta, generates IL-9(+) IL-10(+) Foxp3(-) effector T cells. Nat. Immunol. 9: 1347-1355 (2008). *

• Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med. 206: 2407-2416 (2009). *

• Das UN. A defect in the activity of Delta(6) and Delta(5) desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins Leukot. Essent. Fatty Acids 72: 343-350 (2005). *

• Date M, Matsuzaki K, Matsushita M, Tahashi Y, Furukawa F, Inoue K. Modulation of transforming growth factor beta function in hepatocytes and hepatic stellate cells in rat liver injury. Gut 46: 719-724 (2000). *

• Datta PK, Lianos EA. Retinoic acids inhibit inducible nitric oxide synthase expression in mesangial cells. Kidney Int. 56: 486-493 (1999). *

• Davidson TS, Dipaolo RJ, Andersson J, Shevach EM. Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 178: 4022-4026 (2007). *

• Davies E, Tsang CW, Ghazali AR, Harris RM, Waring RH. Effects of culture with TNF-alpha, TGF-beta and insulin on sulphotransferase (SULT 1A1 and 1A3) activity in human colon and neuronal cell lines. Toxicol. In Vitro 18: 749-754 (2004).

• Davis BH, Vucic A. Modulation of vitamin A metabolism during hepatic and intestinal cell culture. Biochim. Biophys. Acta 1010: 318-324 (1989). *

• Day CP. Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int. 26: 1021-1028 (2006). *

• de Beaucoudrey L, Puel A, Filipe-Santos O, Cobat A, Ghandil P, Chrabieh M, Feinberg J, von Bernuth H, Samarina A, Janniere L, Fieschi C, Stephan JL, Boileau C, Lyonnet S, Jondeau G, Cormier-Daire V, Le Merrer M, Hoarau C, Lebranchu Y, Lortholary O, et al. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J. Exp. Med. 205: 1543-1550 (2008). *

• de Borst M, Prakash J, Sandovici M, Klok PA, Hamming I, Kok RJ, Navis G, van Goor H. c-Jun N-terminal kinase is crucially involved in renal tubulo-interstitial inflammation. J. Pharmacol. Exp. Ther. 331: 896-905 (2009). *

• de Faria IC, de Faria EJ, Toro AA, Ribeiro JD, Bertuzzo CS. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J. Pediatr. (Rio J.) 84: 203-210 (2008).

• de Kozak Y, Omri B, Smith JR, Naud MC, Thillaye-Goldenberg B, Crisanti P. Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13. Am. J. Pathol. 170: 1241-1257 (2007). *

• de Lima TH, Sass N, Mattar R, Moron AF, Torloni MR, Franchim CS, Daher S. Cytokine gene polymorphisms in preeclampsia and eclampsia. Hypertens. Res. 32: 565-569 (2009).

• de Lujan Alvarez M, Ronco MT, Ochoa JE, Monti JA, Carnovale CE, Pisani GB, Lugano MC, Carrillo MC. Interferon alpha-induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor beta(1). Hepatology 40: 394-402 (2004). *

• De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2: 243-253 (2009).

• De Paiva CS, Hwang CS, Pitcher JD 3rd, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford) 49: 246-258 (2010).

• de Saint Jean M, Nakamura T, Wang Y, Trousdale MD, Schechter JE, Mircheff AK. Suppression of lymphocyte proliferation and regulation of dendritic cell phenotype by soluble mediators from rat lacrimal epithelial cells. Scand. J. Immunol. 70: 53-62 (2009). *

• De Souza VR, Cabrera WK, Galvan A, Ribeiro OG, De Franco M, Vorraro F, Starobinas N, Massa S, Dragani TA, Ibañez OM. Aryl hydrocarbon receptor polymorphism modulates DMBA-induced inflammation and carcinogenesis in phenotypically selected mice. Int. J. Cancer 124: 1478-1482 (2009). *

• De Winter H, Elewaut D, Turovskaya O, Huflejt M, Shimeld C, Hagenbaugh A, Binder S, Takahashi I, Kronenberg M, Cheroutre H. Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice. Gastroenterology 122: 1829-1841 (2002). *

• de Zoeten EF, Hancock WW. Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3(+) regulatory T cells. Gastroenterology 134: 2171-2174 (2008). *

• Del Zotto B, Mumolo G, Pronio AM, Montesani C, Tersigni R, Boirivant M. TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis. Clin. Exp. Immunol. 134: 120-126 (2003). *

• Deleuran B, Abraham DJ. Possible implication of the effector CD4(+) T-cell subpopulation T(H)17 in the pathogenesis of systemic scleroderma. Nat. Clin. Pract. Rheumatol. 3: 682-683 (2007). *

• Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30: 832-844 (2009). *

• Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 15: 2579-2585 (2001). *

• Demeo DL, Campbell EJ, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Silverman EK. IL10 polymorphisms are associated with airflow obstruction in severe alpha 1-antitrypsin deficiency. Am. J. Respir. Cell. Mol. Biol. 38: 114-120 (2008). *

• Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8: 1086-1094 (2007). *

• Denton CP, Black CM, Abraham DJ. Mechanisms and consequences of fibrosis in systemic sclerosis. Nat. Clin. Pract. Rheumatol. 2: 134-144 (2006). *

• Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, Hsu VM, Silliman N, Streisand J, Powell J, Akesson A, Coppock J, Hoogen F, Herrick A, Mayes MD, Veale D, Haas J, Ledbetter S, Korn JH, Black CM, Seibold JR; Cat-192 Study Group. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 56: 323-333 (2007). *

• Detlefsen S, Sipos B, Zhao J, Drewes AM, Kloppel G. Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors. Am. J. Surg. Pathol. 32: 986-995 (2008).

• Dheen ST, Jun Y, Yan Z, Tay SS, Ling EA. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia 50: 21-31 (2005). *

• Di Campli C, Gasbarrini G, Gasbarrini A. Review article: a medicine based on cell transplantation - is there a future for treating liver diseases? Aliment. Pharmacol. Ther. 18: 473-480 (2003). *

• Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J. Immunol. 174: 3237-3246 (2005). *

• Di Mola FF, Di Sebastiano P, Gardini A, Innocenti P, Zimmermann A, Buchler MW, Friess H. Differential expression of connective tissue growth factor in inflammatory bowel disease. Digestion 69: 245-253 (2004).

• Di Renzo F, Corsini E, Broccia ML, Marinovich M, Galli CL, Giavini E, Menegola E. Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development. Toxicol. Appl. Pharmacol. 234: 107-116 (2009). *

• Di Sabatino A, Jackson C, Pickard K, Buckley M, Leakey N, Picariello L, Monteleone G, Tonelli F, Corazza GR, MacDonald TT, Pender S. Transforming growth factor-beta signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures. Gut 58: 777-789 (2009).

• Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L, Leakey NA, Croft NM, Troncone R, Corazza GR, Stagg AJ, Monteleone G, Macdonald TT. Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology 133: 1175-1187 (2007). *

• Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA, Corazza GR, Monteleone G, Macdonald TT. Blockade of transforming growth factor beta up-regulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 57: 605-612 (2008).

• Di Sario A, Bendia E, Macarri G, Candelaresi C, Taffetani S, Marzioni M, Omenetti A, De Minicis S, Trozzi L, Benedetti A. The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2. Dig. Liver Dis. 36: 744-751 (2004).

• Di Sario A, Bendia E, Svegliati Baroni G, Ridolfi F, Casini A, Ceni E, Saccomanno S, Marzioni M, Trozzi L, Sterpetti P, Taffetani S, Benedetti A. Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production. J. Hepatol. 37: 584-591 (2002).

• Di Sario A, Bendia E, Taffetani S, Omenetti A, Candelaresi C, Marzioni M, De Minicis S, Benedetti A. Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-vitamin E complex in rats. Dig. Liver Dis. 37: 869-876 (2005).

• Diehl AM. Role of the immune system in the pathogenesis of nonalcoholic steatohepatitis. Falk Symposium 146: GUT-LIVER INTERACTIONS: BASIC AND CLINICAL CONCEPTS, Innsbruck (Austria), March 11-12, 2005, p. 78 (2005). *

• Dieleman LA, Elson CO, Tennyson GS, Beagley KW. Kinetics of cytokine expression during healing of acute colitis in mice. Am. J. Physiol. 271: G130-G136 (1996).

• Dieleman LA, Goerres MS, Arends A, Sprengers D, Torrice C, Hoentjen F, Grenther WB, Sartor RB. Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment. Gut 52: 370-376 (2003). *

• Dieleman LA, Hoentjen F, Qian BF, Sprengers D, Tjwa E, Torres MF, Torrice CD, Sartor RB, Tonkonogy SL. Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats. Clin. Exp. Immunol. 136: 30-39 (2004). *

• Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 105: 1323-1332 (1993).

• Ding W, Mouzaki M, You H, Laird JC, Mato J, Lu SC, Rountree CB. CD133(+) liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology 49: 1277-1286 (2009). *

• Dioszeghy V, Rosas M, Maskrey BH, Colmont C, Topley N, Chaitidis P, Kuhn H, Jones SA, Taylor PR, O'Donnell VB. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. J. Immunol. 181: 6514-6524 (2008). *

• Dipaolo RJ, Brinster C, Davidson TS, Andersson J, Glass D, Shevach EM. Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 179: 4685-4693 (2007). *

• Distler J, Distler O. Novel treatment approaches to fibrosis in scleroderma. Rheum. Dis. Clin. North Am. 34: 145-159 (2008).

• Distler JH, Jungel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Muller-Ladner U, Lorenz HM, Gay S, Distler O. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum. 52: 856-864 (2005). *

• Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 182: 5748-5756 (2009).

• Diveu C, McGeachy MJ, Cua DJ. Cytokines that regulate autoimmunity. Curr. Opin. Immunol. 20: 663-668 (2008). *

• Djoba Siawaya JF, Beyers N, van Helden P, Walzl G. Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis. Clin. Exp. Immunol. 156: 69-77 (2009). *

• Dmitrienko S, Hoar DI, Balshaw R, Keown PA. Immune response gene polymorphisms in renal transplant recipients. Transplantation 80: 1773-1782 (2005).

• Do JS, Fink PJ, Li L, Spolski R, Robinson J, Leonard WJ, Letterio JJ, Min B. Cutting edge: spontaneous development of IL-17-producing gammadelta T cells in the thymus occurs via a TGF-beta1-dependent mechanism. J. Immunol. Jan 8 [Epub ahead of print] (2010).

• Docke WD, Asadullah K, Belbe G, Ebeling M, Hoflich C, Friedrich M, Sterry W, Volk HD. Comprehensive biomarker monitoring in cytokine therapy: heterogeneous, time-dependent, and persisting immune effects of interleukin-10 application in psoriasis. J. Leukoc. Biol. 85: 582-593 (2009). *

• Dodge R, Loomans C, Sharma A, Bonner-Weir S. Developmental pathways during in vitro progression of human islet neogenesis. Differentiation 77: 135-147 (2009). *

• Doetze A, Satoguina J, Burchard G, Rau T, Loliger C, Fleischer B, Hoerauf A. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. Int. Immunol. 12: 623-630 (2000). *

• Doh KO, Jung HK, Moon IJ, Kang HG, Park JH, Park JG. Prevention of CCl4-induced liver cirrhosis by ribbon antisense to transforming growth factor-beta1. Int. J. Mol. Med. 21: 33-39 (2008). *

• Dohi T, Ejima C, Kato R, Kawamura YI, Kawashima R, Mizutani N, Tabuchi Y, Kojima I. Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology 128: 411-423 (2005). *

• Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J. Immunol. 179: 2041-2045 (2007). *

• Donaldson PT, Norris S. Immunogenetics in PSC. Best Pract. Res. Clin. Gastroenterol. 15: 611-627 (2001). *

• Donnelly S, Dalton JP, Loukas A. Proteases in helminth- and allergen-induced inflammatory responses. Chem. Immunol. Allergy 90: 45-64 (2006).

• Dorfman R, Sandford A, Taylor C, Huang B, Frangolias D, Wang Y, Sang R, Pereira L, Sun L, Berthiaume Y, Tsui LC, Pare PD, Durie P, Corey M, Zielenski J. Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J. Clin. Invest. 118: 1040-1049 (2008). *

• Dray X, Marteau P. The use of enteral nutrition in the management of Crohn's disease in adults. JPEN J. Parenter. Enteral Nutr. 29: S166-S172 (2005). *

• Drel VR, Xu W, Zhang J, Pavlov IA, Shevalye H, Slusher B, Obrosova IG. Poly(adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy. Endocrinology 150: 5273-5283 (2009). *

• Druilhe A, Zahm JM, Benayoun L, El Mehdi D, Grandsaigne M, Dombret MC, Mosnier I, Feger B, Depondt J, Aubier M, Pretolani M. Epithelium expression and function of retinoid receptors in asthma. Am. J. Respir. Cell. Mol. Biol. 38: 276-282 (2008). *

• Drumm ML, Konstan MW, Schluchter MD, Handler A, Pace R, Zou F, Zariwala M, Fargo D, Xu A, Dunn JM, Darrah RJ, Dorfman R, Sandford AJ, Corey M, Zielenski J, Durie P, Goddard K, Yankaskas JR, Wright FA, Knowles MR; Gene Modifier Study Group. Genetic modifiers of lung disease in cystic fibrosis. N. Engl. J. Med. 353: 1443-1453 (2005). *

• Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J. Clin. Invest. 116: 1360-1370 (2006). *

• Duan RS, Link H, Xiao BG. Long-term effects of IFN-gamma, IL-10, and TGF-beta-modulated dendritic cells on immune response in Lewis rats. J. Clin. Immunol. 25: 50-56 (2005). *

• Dubois RN. Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention. Curr. Opin. Gastroenterol. 17: 65-71 (2001).

• Ducale AE, Ward SI, Dechert T, Yager DR. Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1beta mediated induction. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G462-G470 (2005). *

• Dullaers M, Li D, Xue Y, Ni L, Gayet I, Morita R, Ueno H, Palucka KA, Banchereau J, Oh S. A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity 30: 120-129 (2009). *

• Dulos J, Boots AH. DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad. Ann. N. Y. Acad. Sci. 1069: 401-413 (2006). *

• Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 52: 770-778 (2005). *

• Dutt SS, Chen N, Darbary HK, Swede H, Petrelli NJ, Stoler DL, Anderson GR. Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age. Mutat. Res. 645: 27-32 (2008).

• Dutzan N, Gamonal J, Silva A, Sanz M, Vernal R. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J. Clin. Periodontol. 36: 396-403 (2009).

• Dybkaer K, Iqbal J, Zhou G, Geng H, Xiao L, Schmitz A, D' Amore F, Chan WC. Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways. BMC Genomics 8: 230 (2007). *

• Dziadzio M, Smith RE, Abraham DJ, Black CM, Denton CP. Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score. Rheumatology (Oxford) 44: 1518-1524 (2005). *

• Ea CK, Sun L, Inoue JI, Chen ZJ. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc. Natl. Acad. Sci. U.S.A. 101: 15318-15323 (2004). *

• Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S. Foxp3(+) regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J. Clin. Immunol. Nov 20 [Epub ahead of print] (2009). *

• Ebert EC, Panja A, Das KM, Praveen R, Geng X, Rezac C, Bajpai M. Patients with inflammatory bowel disease may have a transforming growth factor-beta-, interleukin (IL)-2- or IL-10-deficient state induced by intrinsic neutralizing antibodies. Clin. Exp. Immunol. 155: 65-71 (2009). *

• Ebinc FA, Derici U, Gonen S, Reis KA, Erten Y, Bali M, Sindel S, Arinsoy T. TGF-beta1 gene polymorphisms and peritoneal equilibration test results in CAPD patients. Ren. Fail. 30: 15-19 (2008).

• Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, Tobias J, Kwok WW, Chang KM. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J. Virol. 82: 5043-5053 (2008). *

• Efrati S, Berman S, Chachashvili A, Cohen N, Siman-Tov Y, Averbukh Z, Weissgarten J. Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction. Nephrology (Carlton) 14: 189-197 (2009).

• Egger B, Buchler MW, Lakshmanan J, Moore P, Eysselein VE. Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis. Scand. J. Gastroenterol. 35: 1181-1187 (2000). *

• Eichhorst ST. Modulation of apoptosis as a target for liver disease. Expert Opin. Ther. Targets 9: 83-99 (2005).

• Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation 119: 1424-1432 (2009).

• Eisenhut M. Changes in ion transport in inflammatory disease. J. Inflamm. (Lond.) 3: 5 (2006). *

• Eken C, Gasser O, Zenhaeusern G, Oehri I, Hess C, Schifferli JA. Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells. J. Immunol. 180: 817-824 (2008). *

• El Gazzar M. HMGB1 modulates inflammatory responses in LPS-activated macrophages. Inflamm. Res. 56: 162-167 (2007). *

• El Mabrouk M, Qureshi HY, Li WQ, Sylvester J, Zafarullah M. Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes. J. Cell. Biochem. 103: 588-597 (2008). *

• El-Behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J. Immunol. 183: 4957-4967 (2009). *

• El-Swefy S, Hassanen SI. Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats. Ann. Hepatol. 8: 41-49 (2009). *

• Elder LT, Klein SB, Tavakkol A, Fisher GJ, Nickoloff BJ, Voorhees JJ. Growth factor and proto-oncogene expression in psoriasis. J. Invest. Dermatol. 95: 7S-9S (1990). *

• Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111: 1013-1020 (2008). *

• Eliopoulos DG, Mavroudi I, Pontikoglou C, Ximeri M, Stavroulaki E, Pyrovolaki K, Velegraki M, Spanoudakis M, Goulielmos G, Papadaki HA. The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. Eur. J. Haematol. Jul 14 [Epub ahead of print] (2009).

• Elliott DE, Summers RW, Weinstock JV. Helminths and the modulation of mucosal inflammation. Curr. Opin. Gastroenterol. 21: 51-58 (2005).

• Elrefaei M, Burke CM, Baker CA, Jones NG, Bousheri S, Bangsberg DR, Cao H. TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. PLoS One 4: e8194 (2009). *

• Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10: 927-939 (2005).

• Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 12885-12890 (2009). *

• Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisakk P, Chiba S, Yagita H, Khoury SJ. Jagged1 and Delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179: 5990-5998 (2007). *

• Enders GA. Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta. Br. J. Cancer 97: 1388-1392 (2007). *

• Enghard P, Riemekasten G. Regulatory T cells - a possible promising target in the treatment of autoimmune diseases. Z. Rheumatol. 62: 355-360 (2003).

• Enk AH. DCs and cytokines cooperate for the induction of Tregs. Ernst Schering Res. Found. Workshop 56: 97-106 (2006).

• Eriksson P, Andersson C, Ekerfelt C, Ernerudh J, Skogh T. Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjogren's syndrome, rheumatoid arthritis and healthy controls. Clin. Exp. Immunol. 137: 617-620 (2004). *

• Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. Osteoblastic responses to TGF-beta during bone remodeling. Mol. Biol. Cell 9: 1903-1918 (1998). *

• Esquerre M, Tauzin B, Guiraud M, Muller S, Saoudi A, Valitutti S. Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 105: 2550-2555 (2008). *

• Essakalli M, Brick C, Bennani N, Benseffaj N, Ouadghiri S, Atouf O. The latest TH17 lymphocyte in the family of T CD4+ lymphocytes. Pathol. Biol. (Paris) Mar 17 [Epub ahead of print] (2009).

• Esteban-Pretel G, Marín MP, Renau-Piqueras J, Barber T, Timoneda J. Vitamin A deficiency alters rat lung alveolar basement membrane: reversibility by retinoic acid. J. Nutr. Biochem. Mar 5 [Epub ahead of print] (2009). *

• Evans HG, Suddason T, Jackson I, Taams LS, Lord GM. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl. Acad. Sci. U.S.A. 104: 17034-17039 (2007). *

• Fagenholz PJ, Warren SM, Greenwald JA, Bouletreau PJ, Spector JA, Crisera FE, Longaker MT. Osteoblast gene expression is differentially regulated by TGF-beta isoforms. J. Craniofac. Surg. 12: 183-190 (2001).

• Fahim NM, Monir E. Functional role of CD4+CD25+ regulatory T cells and transforming growth factor-beta1 in childhood immune thrombocytopenic purpura. Egypt. J. Immunol. 13: 173-187 (2006).

• Fahlen L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. 201: 737-746 (2005). *

• Fainaru O, Shay T, Hantisteanu S, Goldenberg D, Domany E, Groner Y. TGFbeta-dependent gene expression profile during maturation of dendritic cells. Genes Immun. 8: 239-244 (2007). *

• Fainaru O, Shseyov D, Hantisteanu S, Groner Y. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Natl. Acad. Sci. U.S.A. 102: 10598-10603 (2005). *

• Fairweather D, Cihakova D. Alternatively activated macrophages in infection and autoimmunity. J. Autoimmun. 33: 222-230 (2009).

• Falasca L, Iadevaia V, Ciccosanti F, Melino G, Serafino A, Piacentini M. Transglutaminase type II is a key element in the regulation of the anti-inflammatory response elicited by apoptotic cell engulfment. J. Immunol. 174: 7330-7340 (2005). *

• Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176: 6752-6761 (2006). *

• Fallarino F, Luca G, Calvitti M, Mancuso F, Nastruzzi C, Fioretti MC, Grohmann U, Becchetti E, Burgevin A, Kratzer R, van Endert P, Boon L, Puccetti P, Calafiore R. Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. J. Exp. Med. 206: 2511-2526 (2009). *

• Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Zhang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J. Lysine 63-linked polyubiquitination of transforming growth factor-beta-activated kinase 1 at lysine 158 is required for tumor necrosis factor alpha and interleukin-1 beta-induced IkappaB kinase/nuclear factor-kappaB and c-JUN N-terminal kinase … J. Biol. Chem. Dec 28 [Epub ahead of print] (2009). *

• Fang F, Yu L, Zhong Y, Yao L. TGFB1 509 C/T polymorphism and colorectal cancer risk: a meta-analysis. Med. Oncol. Dec 14 [Epub ahead of print] (2009). *

• Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153 (2004). *

• Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle PR, Neurath MF. TGF-beta induced Foxp3+ regulatory T cells suppress Th1-mediated experimental colitis. Gut 55: 671-680 (2006). *

• Fantini MC, Dominitzki S, Rizzo A, Neurath MF, Becker C. In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells. Nat. Protoc. 2: 1789-1794 (2007).

• Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur. J. Immunol. 37: 3155-3163 (2007). *

• Fantini MC, Rizzo A, Fina D, Caruso R, Sarra M, Stolfi C, Becker C, Macdonald TT, Pallone F, Neurath MF, Monteleone G. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 136: 1308-1316.e3 (2009). *

• Faria AM, Weiner HL. Oral tolerance. Immunol. Rev. 206: 232-259 (2005). *

• Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin. Dev. Immunol. 13: 143-157 (2006). *

• Faria EJ, Faria IC, Ribeiro JD, Ribeiro AF, Hessel G, Bertuzzo CS. Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. J. Bras. Pneumol. 35: 334-342 (2009).

• Farkas G Jr, Hofner P, Balog A, Takacs T, Szabolcs A, Farkas G, Mandi Y. Relevance of transforming growth factor-beta1, interleukin-8, and tumor necrosis factor-alpha polymorphisms in patients with chronic pancreatitis. Eur. Cytokine Netw. 18: 26-32 (2007).

• Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK. Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J. Immunol. 183: 7297-7306 (2009). *

• Faust SM, Lu G, Wood SC, Bishop DK. TGFbeta neutralization within cardiac allografts by Decorin gene transfer attenuates chronic rejection. J. Immunol. 183: 7307-7313 (2009).

• Favorova OO, Favorov AV, Boiko AN, Andreewski TV, Sudomoina MA, Alekseenkov AD, Kulakova OG, Gusev EI, Parmigiani G, Ochs MF. Three allele combinations associated with multiple sclerosis. BMC Med. Genet. 7: 63 (2006). *

• Feillet H, Bach JF. Increased incidence of inflammatory bowel disease: the price of the decline of infectious burden? Curr. Opin. Gastroenterol. 20: 560-564 (2004).

• Fell JM. Control of systemic and local inflammation with transforming growth factor beta containing formulas. JPEN J. Parenter. Enteral Nutr. 29: S126-S133 (2005). *

• Felley C, Michetti P. Engineered lymphocytes to treat dinitrobenzene sulphonic acid colitis in mice. Eur. J. Gastroenterol. Hepatol. 15: 1253-1255 (2003).

• Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. Electrophilic peroxisome proliferator activated receptor-gamma ligands have potent anti-fibrotic effects in human lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 41: 722-730 (2009). *

• Fernandez-Calotti P, Pastor-Anglada M. All-trans retinoic acid promotes trafficking of human concentrative nucleoside transporter-3 (hCNT3) to the plasma membrane by a TGF-beta1-mediated mechanism. J. Biol. Chem. Feb 19 [Epub ahead of print] (2010). *

• Ferrera F, Hahn BH, Rizzi M, Anderson M, Fitzgerald J, Millo E, Indiveri F, Shi FD, Filaci G, La Cava A. Protection against renal disease in (NZB x NZW)F(1) lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptide. Arthritis Rheum. 56: 1945-1953 (2007). *

• Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Martin A, Andres-Lacueva C, Senin U, Guralnik JM. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J. Clin. Endocrinol. Metab. 91: 439-446 (2006). *

• Fiaccavento R, Carotenuto F, Minieri M, Masuelli L, Vecchini A, Bei R, Modesti A, Binaglia L, Fusco A, Bertoli A, Forte G, Carosella L, Di Nardo P. alpha-Linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters. Am. J. Pathol. 169: 1913-1924 (2006). *

• Fiala M. Re-balancing of inflammation and immunity as a therapeutic for Alzheimer's disease - view from the bedside. CNS Neurol. Disord. Drug Targets Oct 7 [Epub ahead of print] (2009).

• Fiasse R, Latinne D. Intestinal helminths: a clue explaining the low incidence of inflammatory bowel diseases in Subsaharan Africa? Potential benefits and hazards of helminth therapy. Acta Gastroenterol. Belg. 69: 418-422 (2006).

• Fichtner-Feigl S, Fuss IJ, Young CA, Watanabe T, Geissler EK, Schlitt HJ, Kitani A, Strober W. Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J. Immunol. 178: 5859-5870 (2007). *

• Fichtner-Feigl S, Strober W, Geissler EK, Schlitt HJ. Cytokines mediating the induction of chronic colitis and colitis-associated fibrosis. Mucosal Immunol. 1 Suppl. 1: S24-S27 (2008).

• Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha(2) receptor is involved in induction of TGF-beta(1) production and fibrosis. Nat. Med. 12: 99-106 (2006). *

• Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, Strober W. IL-13 signaling via IL-13Ralpha(2) induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 135: 2003-2013.e7 (2008). *

• Fickert P, Fuchsbichler A, Wagner M, Zollner G, Kaser A, Tilg H, Krause R, Lammert F, Langner C, Zatloukal K, Marschall HU, Denk H, Trauner M. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (abcb4) knockout mice. Gastroenterology 127: 261-274 (2004). *

• Fifadara NH, Aye CC, Raghuwanshi SK, Richardson RM, Ono SJ. CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6. Int. Immunol. 21: 991-1001 (2009).

• Filippi CM, Estes EA, Oldham JE, von Herrath MG. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. J. Clin. Invest. 119: 1515-1523 (2009). *

• Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG. Transforming growth factor-beta suppresses the activation of CD8+ T cells when naive but promotes their survival and function once antigen-experienced: a two-faced impact on autoimmunity. Diabetes 57: 2684-2692 (2008). *

• Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I, Dottori M, Boirivant M, Pallone F, Macdonald TT, Monteleone G. Regulation of gut inflammation and Th17 cell response by interleukin-21. Gastroenterology 134: 1038-1048 (2008). *

• Fink LN, Frikiaer H. Dendritic cells from Peyer's patches and mesenteric lymph nodes differ from spleen dendritic cells in their response to commensal gut bacteria. Scand. J. Immunol. 68: 270-279 (2008). *

• Finotto S. T-cell regulation in asthmatic diseases. Chem. Immunol. Allergy 94: 83-92 (2008).

• Fiocchi C. TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation. J. Clin. Invest. 108: 523-526 (2001). *

• Fiorucci S. FXR and liver fibrosis. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 67-69 (2006). *

• Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pellicciari R, Morelli A. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 127: 1497-1512 (2004). *

• Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Antonio M, Pruzanski M, Pelllicciari R. Cross-talk between farnesoid X-receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) gamma contributes to the anti-fibrotic activity of FXR ligands in rodent models of liver cirrhosis. J. Pharmacol. Exp. Ther. 315: 58-68 (2005). *

• Fitch EL, Rizzo HL, Kurtz SE, Wegmann KW, Gao W, Benson JM, Hinrichs DJ, Blauvelt A. Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway. J. Invest. Dermatol. 129: 2443-2450 (2009). *

• Fitzner B, Holzhueter SA, Ibrahim S, Nizze H, Jaster R. Interferon-gamma treatment accelerates and aggravates autoimmune pancreatitis in the MRL/Mp-mouse. Pancreatology 9: 233-239 (2009).

• Flanders KC. Smad3 as a mediator of the fibrotic response. Int. J. Exp. Pathol. 85: 47-64 (2004). *

• Flanders KC, Burmester JK. Medical applications of transforming growth factor-beta. Clin. Med. Res. 1: 13-20 (2003). *

• Flavell RA. Molecular immunologic approaches to the study of inflammatory bowel diseases. Falk Symposium 142: GASTROENTEROLOGY WEEK FREIBURG 2004 (Part I) AUTOIMMUNE LIVER DISEASE, Freiburg (Germany), October 12 - 13, 2004, p. 19 (2004). *

• Flisiak I, Zaniewski P, Chodynicka B. Plasma TGF-beta1, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity. Biomarkers 13: 549-556 (2008).

• Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the Foxp3 locus in regulatory T cells. PLoS Biol. 5: e38 (2007). *

• Fonseca C, Lindahl GE, Ponticos M, Sestini P, Renzoni EA, Holmes AM, Spagnolo P, Pantelidis P, Leoni P, McHugh N, Stock CJ, Shi-Wen X, Denton CP, Black CM, Welsh KI, du Bois RM, Abraham DJ. A polymorphism in the CTGF promoter region associated with systemic sclerosis. N. Engl. J. Med. 357: 1210-1220 (2007). *

• Forsberg G, Hernell O, Hammarstrom S, Hammarstrom ML. Concomitant increase of IL-10 and pro-inflammatory cytokines in intraepithelial lymphocyte subsets in celiac disease. Int. Immunol. 19: 993-1001 (2007). *

• Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarstrom S, Hammarstrom ML. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 123: 667-678 (2002). *

• Forsthuber TG, Shive CL, Wienhold W, de Graaf K, Spack EG, Sublett R, Melms A, Kort J, Racke MK, Weissert R. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J. Immunol. 167: 7119-7125 (2001). *

• Forsyth CB, Banan A, Farhadi A, Fields JZ, Tang Y, Shaikh M, Zhang L, Engen PA, Keshavarzian A. Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. J. Pharmacol. Exp. Ther. 321: 84-97 (2007). *

• Fosslien E. Molecular pathology of cyclooxygenase-2 in neoplasia. Ann. Clin. Lab. Sci. 30: 3-21 (2000).

• Fournier T, Handschuh K, Tsatsaris V, Evain-Brion D. Involvement of PPARgamma in human trophoblast invasion. Placenta 28 Suppl. A: S76-S81 (2007).

• Fouser LA, Wright JF, Dunussi-Joannopoulos K, Collins M. Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol. Rev. 226: 87-102 (2008). *

• Foussat A, Cottrez F, Brun V, Fournier N, Breittmayer JP, Groux H. A comparative study between T regulatory type 1 and CD4(+)CD25(+) T cells in the control of inflammation. J. Immunol. 171: 5018-5026 (2003). *

• Franceschi DS, Mazini PS, Rudnick CC, Sell AM, Tsuneto LT, Ribas ML, Peixoto PR, Visentainer JE. Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil. Int. J. Infect. Dis. 13: 493-498 (2009).

• Francoeur C, Escaffit F, Vachon PH, Beaulieu JF. Pro-inflammatory cytokines TNFalpha and IFNgamma alter laminin expression under an apoptosis-independent mechanism in human intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G592-G598 (2004). *

• Frangogiannis NG. The mechanistic basis of infarct healing. Antioxid. Redox Signal. 8: 1907-1939 (2006).

• Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr. Med. Chem. 13: 1877-2893 (2006).

• Fransvea E, Mazzocca A, Antonaci S, Giannelli G. Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma. Hepatology 49: 839-850 (2009).

• Frey O, Brauer R. Regulatory T cells: magic bullets for immunotherapy? Arch. Immunol. Ther. Exp. (Warsz.) 54: 33-43 (2006).

• Fried L, Kirsner RS, Bhandarkar S, Arbiser JL. Efficacy of rapamycin in scleroderma: a case study. Lymphat. Res. Biol. 6: 217-219 (2008).

• Friedman SL. Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye. J. Hepatol. 46: 180-182 (2007). *

• Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR, Fairweather D. Cutting edge: T cell Ig Mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J. Immunol. 176: 6411-6415 (2006). *

• Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM, Birchmeier W. A colorectal cancer expression profile that includes transforming growth factor ss inhibitor BAMBI predicts metastatic potential. Gastroenterology 137: 165-175 (2009). *

• Froh M, Conzelmann L, Walbrun P, Netter S, Wiest R, Wheeler MD, Lehnert M, Uesugi T, Scholmerich J, Thurman RG. Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats. World J. Gastroenterol. 13: 3478-3486 (2007). *

• Frossard CP, Hauser C, Eigenmann PA. Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. J. Allergy Clin. Immunol. 114: 377-382 (2004). *

• Frumento G, Piazza T, Di Carlo E, Ferrini S. Targeting tumor-related immunosuppression for cancer immunotherapy. Endocr. Metab. Immune Disord. Drug Targets 6: 233-237 (2006).

• Fu S, Zhang N, Yopp AC, Chen D, Mao M, Chen D, Zhang H, Ding Y, Bromberg JS. TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors. Am. J. Transplant. 4: 1614-1627 (2004). *

• Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X. Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection. J. Huazhong Univ. Sci. Technolog. Med. Sci. 29: 481-485 (2009).

• Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X. Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis. Mediators Inflamm. 2009: 517052 (2009). *

• Fu Y, Zheng S, Lin J, Ryerse J, Chen A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol. Pharmacol. 73: 399-409 (2008). *

• Fujimiya T, Liu J, Kojima H, Shirafuji S, Kimura H, Fujimiya M. Pathological roles of bone-marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G451-G460 (2009). *

• Fujimoto J. Reversal of liver cirrhosis by hepatocyte growth factor. Falk Symposium 138. XII FALK LIVER WEEK 2003 (Part III) In Honour of Hans Popper’s 100th Birthday. State-of-the-art of hepatology: Molecular and Cell Biology. Freiburg (Germany). p. 41. October 20 - 21 (2003). *

• Fujimoto M, Hasegawa M, Hamaguchi Y, Komura K, Matsushita T, Yanaba K, Kodera M, Takehara K, Sato S. A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease. Dermatology 213: 88-92 (2006).

• Fujimoto M, Serada S, Naka T. Role of IL-6 in the development and pathogenesis of CIA and EAE. Nihon Rinsho Meneki Gakkai Kaishi 31: 78-84 (2008).

• Fujishiro J, Suzuki C, Kudou S, Yasue T, Hakamata Y, Takahashi M, Murakami T, Hashizume K, Kobayashi E. Change from cyclosporine to combination therapy of mycophenolic acid with the new sphingosine-1-phosphate receptor agonist, KRP-203, prevents host nephrotoxicity and transplant vasculopathy in rats. J. Heart Lung Transplant. 25: 825-833 (2006).

• Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S. Impaired angiogenic response in the cornea of mice lacking osteopontin. Invest. Ophthalmol. Vis. Sci. Sep 9 [Epub ahead of print] (2009).

• Fujiwara I, Yashiro M, Kubo N, Maeda K, Hirakawa K. Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. Dis. Colon Rectum 51: 1387-1394 (2008). *

• Fukamachi H, Ito K. Growth regulation of gastric epithelial cells by Runx3. Oncogene 23: 4330-4335 (2004). *

• Fukui J, Inaba M, Ueda Y, Miyake T, Hosaka N, Kwon AH, Sakaguchi Y, Tsuda M, Omae M, Kamiyama Y, Ikehara S. Prevention of graft-versus-host disease by intra-bone marrow injection of donor T cells. Stem Cells 25: 1595-1601 (2007). *

• Furuzawa-Carballeda J, Vargas-Rojas MI, Cabral AR. Autoimmune inflammation from the Th17 perspective. Autoimmun. Rev. 6: 169-175 (2007). *

• Fusaro AE, de Brito CA, Taniguchi EF, Muniz BP, Victor JR, Orii NM, Duarte AJ, Sato MN. Balance between early life tolerance and sensitization in allergy: dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother. Immunology 128: e541-e550 (2009).

• Futagami Y, Sugita S, Vega J, Ishida K, Takase H, Maruyama K, Aburatani H, Mochizuki M. Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells. J. Immunol. 178: 6994-7005 (2007). *

• Gabele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Scholmerich J, Brenner DA, Thurman RG, Rippe RA. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem. Biophys. Res. Commun. 378: 348-353 (2009). *

• Gajewski TF, Meng Y, Blank C, Brown I, Kacha A, Kline J, Harlin H. Immune resistance orchestrated by the tumor microenvironment. Immunol. Rev. 213: 131-145 (2006). *

• Galdo FD, Jimenez SA. T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro. Arthritis Rheum. 56: 3478-3488 (2007). *

• Galicia G, Kasran A, Uyttenhove C, De Swert K, Van Snick J, Ceuppens JL. ICOS deficiency results in exacerbated IL-17 mediated experimental autoimmune encephalomyelitis. J. Clin. Immunol. 29: 426-433 (2009). *

• Gandhi R, Anderson DE, Weiner HL. Cutting edge: immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. J. Immunol. 178: 4017-4021 (2007). *

• Gao D, Wang R, Li B, Yang Y, Zhai Z, Chen DY. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell. Mol. Life Sci. 66: 2573-2584 (2009). *

• Garcia D, Angel B, Carrasco E, Albala C, Santos JL, Perez-Bravo F. VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile. Diabetes Res. Clin. Pract. 77: 134-140 (2007).

• Garcia-Gonzalez MA, Strunk M, Piazuelo E, Benito R, Santolaria S, Jimenez P, Sopena F, Pascual C, Simon MA, Sainz R, Lanas A. TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases. Genes Immun. 7: 640-646 (2006). *

• Garcia-Lazaro JF, Thieringer F, Luth S, Czochra P, Meyer E, Renteria IB, Galle PR, Lohse AW, Herkel J, Kanzler S. Hepatic over-expression of TGF-beta1 promotes LPS-induced inflammatory cytokine secretion by liver cells and endotoxemic shock. Immunol. Lett. 101: 217-222 (2005).

• Garcia-Verdugo I, Tattermusch S, Leduc D, Dif F, Touqui L. Regulation of MUC5AC expression by arachidonic acid metabolites. Rev. Mal. Respir. 25: 1187 (2008).

• Gargano JW, Holzman C, Senagore P, Thorsen P, Skogstrand K, Hougaard DM, Rahbar MH, Chung H. Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth. J. Reprod. Immunol. 79: 100-110 (2008). *

• Garman JH, Mulroney SE, Manigrasso M, Flynn E, Maric C. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am. J. Physiol. Renal Physiol. 296: F306-F316 (2009). *

• Garrote J, Arranz E, Gomez-Gonzalez E, Leon A, Farre C, Calvo C, Bernardo D, Fernandez-Salazar L, Blanco-Quiros A. IL6, IL10 and TGFB1 gene polymorphisms in coeliac disease: differences between DQ2 positive and negative patients. Allergol. Immunopathol. (Madr.) 33: 245-249 (2005).

• Gassull MA, Cabre E. Nutrition in inflammatory bowel disease. Curr. Opin. Clin. Nutr. Metab. Care 4: 561-569 (2001).

• Gaudreault E, Gosselin J. Leukotriene B4 potentiates CpG signaling for enhanced cytokine secretion by human leukocytes. J. Immunol. 183: 2650-2658 (2009).

• Ge Z, Rogers AB, Feng Y, Lee A, Xu S, Taylor NS, Fox JG. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell. Microbiol. 9: 2070-2080 (2007). *

• Gebhardt T, Lorentz A, Detmer F, Trautwein C, Bektas H, Manns MP, Bischoff SC. Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1. Gut 54: 928-934 (2005). *

• Gendzekhadze K, Rivas-Vetencourt P, Montano RF. Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF-alpha -308 single nucleotide polymorphisms: a preliminary study. Transpl. Immunol. 16: 194-199 (2006).

• Geng ZM, Zheng JB, Zhang XX, Tao J, Wang L. Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture. World J. Gastroenterol. 14: 4949-4954 (2008). *

• Genovese T, Mazzon E, Di Paola R, Muia C, Crisafulli C, Malleo G, Esposito E, Cuzzocrea S. Role of peroxisome proliferator-activated receptor-alpha in acute pancreatitis induced by cerulein. Immunology 118: 559-570 (2006). *

• George-Chandy A, Nordstrom I, Nygren E, Jonsson IM, Postigo J, Collins LV, Eriksson K. Th17 development and autoimmune arthritis in the absence of reactive oxygen species. Eur. J. Immunol. 38: 1118-1126 (2008). *

• Georgiev P, Jochum W, Heinrich S, Jang JH, Nocito A, Dahm F, Clavien PA. Characterization of time-related changes after experimental bile duct ligation. Br. J. Surg. 95: 646-656 (2008).

• Gercek A, Yildirim O, Konya D, Bozkurt S, Ozgen S, Kilic T, Sav A, Pamir N. Effects of parenteral fish-oil emulsion (omegaven) on cutaneous wound healing in rats treated with dexamethasone. JPEN J. Parenter. Enteral Nutr. 31: 161-166 (2007). *

• Gerger A, Renner W, Langsenlehner T, Hofmann G, Knechtel G, Szkandera J, Samonigg H, Krippl P, Langsenlehner U. Association of interleukin-10 gene variation with breast cancer prognosis. Breast Cancer Res. Treat. May 13 [Epub ahead of print] (2009). *

• Gerosa F, Baldani-Guerra B, Lyakh LA, Batoni G, Esin S, Winkler-Pickett RT, Consolaro MR, De Marchi M, Giachino D, Robbiano A, Astegiano M, Sambataro A, Kastelein RA, Carra G, Trinchieri G. Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J. Exp. Med. 205: 1447-1461 (2008). *

• Ghia JE, Blennerhassett P, Collins SM. Vagus nerve integrity and experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G560-G567 (2007). *

• Ghio M, Contini P, Negrini S, Boero S, Musso A, Poggi A. Soluble HLA-I-mediated secretion of TGF-beta1 by human NK cells and consequent downregulation of anti-tumor cytolytic activity. Eur. J. Immunol. 39: 3459-3468 (2009). *

• Ghio M, Contini P, Negrini S, Proietti M, Gonella R, Ubezio G, Ottonello L, Indiveri F. sHLA-I contaminating molecules as novel mechanism of ex vivo/in vitro transcriptional and posttranscriptional modulation of transforming growth factor-beta in CD8+ T lymphocytes and neutrophils after intravenous immunoglobulin treatment. Transfusion Nov 9 [Epub ahead of print] (2009).

• Ghosh AK, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y, Varga J. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 23: 2968-2977 (2009). *

• Ghosh AK, Wei J, Wu M, Varga J. Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. Biochem. Biophys. Res. Commun. 374: 231-236 (2008). *

• Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129: 1375-1383 (2005). *

• Gidvani V, Ramkissoon S, Sloand EM, Young NS. Cytokine gene polymorphisms in acquired bone marrow failure. Am. J. Hematol. 82: 721-724 (2007). *

• Giebeler A, Boekschoten MV, Klein C, Borowiak M, Birchmeier C, Gassler N, Wasmuth HE, Muller M, Trautwein C, Streetz KL. c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice. Gastroenterology 137: 297-308.e1-e4 (2009). *

• Gilberts EC, Greenstein AJ, Katsel P, Harpaz N, Greenstein RJ. Molecular evidence for two forms of Crohn disease. Proc. Natl. Acad. Sci. U.S.A. 91: 12721-12724 (1994). *

• Gill RM, Lee TH, Utter GH, Reed WF, Wen L, Chafets D, Busch MP. The TNFalpha (-308A) polymorphism is associated with microchimerism in transfused trauma patients. Blood 111: 3880-3883 (2008). *

• Gionanlis L, Alexopoulos E, Papagianni A, Leontsini M, Memmos D. Fibrotic mechanisms in idiopathic rapidly progressive glomerulonephritis: the role of TGF-beta1 and C5b-9. Ren. Fail. 30: 239-246 (2008).

• Giraud AS. Lessons from genetically engineered animal models. X. Trefoil peptide and EGF receptor/ligand transgenic mice. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G501-G506 (2000). *

• Glinka Y, Chang Y, Prud'homme GJ. Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand. Mol. Ther. 14: 578-587 (2006).

• Glisic S, Ehlenbach S, Jailwala P, Waukau J, Jana S, Ghosh S. Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls. Cell Tissue Res. Feb 9 [Epub ahead of print] (2010). *

• Gobel F, Taschner S, Jurkin J, Konradi S, Vaculik C, Richter S, Kneidinger D, Muhlbacher C, Bieglmayer C, Elbe-Burger A, Strobl H. Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation. Blood 114: 3813-3821 (2009). *

• Godebu E, Summers-Torres D, Lin MM, Baaten BJ, Bradley LM. Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells. J. Immunol. 181: 1798-1805 (2008). *

• Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Muller A, Tuschl G, Mueller SO, Dooley S. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology 49: 2031-2043 (2009).

• Goel A, Arnold CN, Tassone P, Chang DK, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int. J. Cancer 112: 754-759 (2004). *

• Goetzl EJ. Changing paradigms in the immunological science of allergy. Curr. Allergy Asthma Rep. 7: 7-10 (2007).

• Goll V, Viollon-Abadie C, Nicod L, Richert L. Peroxisome proliferators induce apoptosis and decrease DNA synthesis in hepatoma cell lines. Hum. Exp. Toxicol. 19: 193-202 (2000).

• Gomez GD, Balcazar JL. A review on the interactions between gut microbiota and innate immunity of fish. FEMS Immunol. Med. Microbiol. 52: 145-154 (2008). *

• Gomez-Duran A, Carvajal-Gonzalez JM, Mulero-Navarro S, Santiago-Josefat B, Puga A, Fernandez-Salguero PM. Fitting a xenobiotic receptor into cell homeostasis: how the dioxin receptor interacts with TGFbeta signaling. Biochem. Pharmacol. 77: 700-712 (2009). *

• Gomez-Martin D, Diaz-Zamudio M, Alcocer-Varela J. Ubiquitination system and autoimmunity: the bridge towards the modulation of the immune response. Autoimmun. Rev. 7: 284-290 (2008).

• Gomez-Mateo J, Marin L, Lopez-Alvarez MR, Moya-Quiles MR, Miras M, Marin-Moreno I, Botella C, Parrilla P, Alvarez-Lopez MR, Muro M. TGF-beta1 gene polymorphism in liver graft recipients. Transpl. Immunol. 17: 55-57 (2006).

• Gong Z, Yan S, Zhang P, Huang Y, Wang L. Effects of S-adenosylmethionine on liver methionine metabolism and steatosis with ethanol-induced liver injury in rats. Hepatol. Int. 2: 346-352 (2008). *

• Gonullu G, Basturk B, Evrensel T, Oral B, Gozkaman A, Manavoglu O. Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med. J. 28: 1728-1733 (2007).

• Gonzalez-García I, Zhao Y, Ju S, Gu Q, Liu L, Kolls JK, Lu B. IL-17 signaling-independent central nervous system autoimmunity is negatively regulated by TGF-beta. J. Immunol. 182: 2665-2671 (2009).

• Gonzalez-Rey E, Chorny A, Del Moral RG, Varela N, Delgado M. Therapeutic effect of cortistatin on experimental arthritis by downregulating inflammatory and Th1 responses. Ann. Rheum. Dis. 66: 582-588 (2007). *

• Gonzalez-Rey E, Chorny A, Varela N, O'Valle F, Delgado M. Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells. Arthritis Rheum. 56: 531-543 (2007). *

• Gonzalez-Rey E, Fernandez-Martin A, Chorny A, Delgado M. Therapeutic action of Ghrelin in a mouse model of colitis. Gastroenterology 130: 1707-1720 (2006). *

• Goo MJ, Ki MR, Lee HR, Yang HJ, Yuan DW, Hong IH, Park JK, Hong KS, Han JY, Hwang OK, Kim DH, Do SH, Cohn RD, Jeong KS. Helicobacter pylori promotes hepatic fibrosis in the animal model. Lab. Invest. 89: 1291-1303 (2009). *

• Gorczynski RM, Alexander C, Bessler W, Brandenburg K, Fournier K, Mach JP, Mueller S, Rietschel ET, Ulmer AJ, Waelli T, Zahringer U, Khatri I. An alteration in the levels of populations of CD4(+) Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. Immunol. Lett. 109: 101-112 (2007).

• Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM, Macdonald TT. Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm. Bowel Dis. 14: 195-203 (2008). *

• Gordon JN, Sabatino AD, Macdonald TT. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr. Opin. Gastroenterol. 21: 431-437 (2005).

• Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2: 46-53 (2002). *

• Goris A, Williams-Gray CH, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Barker RA, Sawcer SJ. Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease. J. Neurol. 254: 846-848 (2007). *

• Gorjao R, Verlengia R, Lima TM, Soriano FG, Boaventura MF, Kanunfre CC, Peres CM, Sampaio SC, Otton R, Folador A, Martins EF, Curi TC, Portiolli EP, Newsholme P, Curi R. Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. Clin. Nutr. 25: 923-938 (2006).

• Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Nagahira K, Fukuda Y, Nishimura T. Murine NKT cells produce Th17 cytokine interleukin-22. Cell. Immunol. 254: 81-84 (2009). *

• Gottenberg JE, Busson M, Loiseau P, Dourche M, Cohen-Solal J, Lepage V, Charron D, Miceli C, Sibilia J, Mariette X. Association of transforming growth factor beta1 and tumor necrosis factor alpha polymorphisms with anti-SSB/La antibody secretion in patients with primary Sjogren's syndrome. Arthritis Rheum. 50: 570-580 (2004). *

• Gottlieb AB. Immunologic mechanisms in psoriasis. J. Invest. Dermatol. 95: 18S-19S (1990). *

• Goulart LR, Goulart IM. Leprosy pathogenetic background: a review and lessons from other mycobacterial diseases. Arch. Dermatol. Res. 301: 123-137 (2009). *

• Gourh P, Mayes MD, Arnett FC. CTGF polymorphism associated with systemic sclerosis. N. Engl. J. Med. 358: 308-309 (2008).

• Granel B, Argiro L, Hachulla E, Fajardy I, Weiller PJ, Durand JM, Frances Y, Dombey AM, Marquet S, Lesavre N, Disdier P, Bernard F, Hatron PY, Chevillard C. Association between a CTGF gene polymorphism and systemic sclerosis in a French population. J. Rheumatol. Dec 23 [Epub ahead of print] (2009).

• Grant C, Oh U, Yao K, Yamano Y, Jacobson S. Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease. Blood 111: 5601-5609 (2008). *

• Grassel S, Rickert M, Opolka A, Bosserhoff A, Angele P, Grifka J, Anders S. Coculture between periosteal explants and articular chondrocytes induces expression of TGF-beta1 and collagen I. Rheumatology (Oxford) 49: 218-230 (2010).

• Grassl GA, Valdez Y, Bergstrom KS, Vallance BA, Finlay BB. Chronic enteric Salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology 134: 768-780.e2 (2008). *

• Grauer O, Poschl P, Lohmeier A, Adema GJ, Bogdahn U. Toll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2. J. Neurooncol. 82: 151-161 (2007). *

• Gredler V, Ebner S, Schanda K, Forstner M, Berger T, Romani N, Reindl M. Impact of human myelin on the maturation and function of human monocyte-derived dendritic cells. Clin. Immunol. Nov 27 [Epub ahead of print] (2009). *

• Green AJ, Barcellos LF, Rimmler JB, Garcia ME, Caillier S, Lincoln RR, Bucher P, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg JR; Multiple Sclerosis Genetics Group. Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility. J. Neuroimmunol. 116: 116-124 (2001).

• Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A. 100: 10878-10883 (2003). *

• Gregori S, Battaglia M, Roncarolo MG. Re-establishing immune tolerance in type 1 diabetes via regulatory T cells. Novartis Found. Symp. 292: 174-183 (2008).

• Gressner OA. Less Smad2 is good for you! A scientific update on coffee's liver benefits. Hepatology 50: 970-978 (2009).

• Gressner OA, Gao C, Rehbein K, Lahme B, Siluschek M, Berg T, Muller T, Gressner AM. Elevated concentrations of 15-deoxy-delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. Liver Int. 29: 730-735 (2009). *

• Gressner OA, Gressner AM. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int. 28: 1065-1079 (2008). *

• Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J. Hepatol. 47: 699-710 (2007).

• Gressner OA, Lahme B, Siluschek M, Gressner AM. Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells. Liver Int. 29: 886-897 (2009). *

• Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - but without modulating bone morphogenetic protein 7 signaling. Hepatology 49: 2021-2030 (2009).

• Gressner OA, Siluschek M, Lahme B, Gressner AM. Intraperitoneal application of caffeine prevents D-galactosamine induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat. J. Hepatol. 50: 1053-1055 (2009).

• Gressner OA, Weiskirchen R, Gressner AM. Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options. Comp. Hepatol. 6: 7 (2007). *

• Griffin S, Carroll TP, Greene CM, O'Neill SJ, Taggart CC, McElvaney NG. Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor. Cell. Microbiol. 9: 670-679 (2007). *

• Grijo NN, Borra RC, Sdepanian VL. Proinflammatory and anti-inflammatory cytokines present in the acute phase of experimental colitis treated with Saccharomyces boulardii. Dig. Dis. Sci. Dec 9 [Epub ahead of print] (2009). *

• Grimbert P, Bouguermouh S, Baba N, Nakajima T, Allakhverdi Z, Braun D, Saito H, Rubio M, Delespesse G, Sarfati M. Thrombospondin/CD47 interaction: a pathway to generate regulatory T cells from human CD4+CD25- T cells in response to inflammation. J. Immunol. 177: 3534-3541 (2006). *

• Groneberg DA, Witt H, Adcock IM, Hansen G, Springer J. Smads as intracellular mediators of airway inflammation. Exp. Lung Res. 30: 223-250 (2004).

• Gronski MA, Kinchen JM, Juncadella IJ, Franc NC, Ravichandran KS. An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response. Cell Death Differ. 16: 1323-1331 (2009). *

• Grutter C, Wilkinson T, Turner R, Podichetty S, Finch D, McCourt M, Loning S, Jermutus L, Grutter MG. A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. Proc. Natl. Acad. Sci. U.S.A. 105: 20251-20256 (2008). *

• Grutters JC, du Bois RM. Genetics of fibrosing lung diseases. Eur. Respir. J. 25: 915-927 (2005). *

• Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol. 9: 77 (2009). *

• Guarner F. Prebiotics, probiotics and helminths: the 'natural' solution? Dig. Dis. 27: 412-417 (2009).

• Guarnizo-Zuccardi P, Lopez Y, Giraldo M, Garcia N, Rodriguez L, Ramirez L, Uribe O, Garcia L, Vasquez G. Cytokine gene polymorphisms in Colombian patients with systemic lupus erythematosus. Tissue Antigens 70: 376-382 (2007). *

• Guerrero A, Fries BC. Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response. Infect. Immun. 76: 4322-4331 (2008). *

• Gunnlaugsdottir B, Skaftadottir I, Ludviksson BR. Naive human T-cells become non-responsive towards anti-TNFalpha (infliximab) treatment in vitro if co-stimulated through CD28. Scand. J. Immunol. 68: 624-634 (2008). *

• Guo J, Hong F, Loke J, Yea S, Lim CL, Lee U, Mann D, Walsh M, Sninsky JJ, Friedman SL. A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells. J. Biol. Chem. Dec 17 [Epub ahead of print] (2009). *

• Guo J, Loke J, Zheng F, Hong F, Yea S, Fugita M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL. Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology 49: 960-968 (2009). *

• Guo YF, Tan JM, Li RY, Liu SZ, Li Y, Ying K, Xie Y, Mao YM. Application of oligoneucleotide array in single nucleotide polymorphism typing of cytokines and cytokine receptors. Zhonghua Yi Xue Za Zhi 85: 1757-1761 (2005).

• Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A. New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. Hum. Mol. Genet. 17: 1838-1844 (2008). *

• Guzy C, Schirbel A, Paclik D, Wiedenmann B, Dignass A, Sturm A. Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro. Eur. J. Nutr. 48: 12-21 (2009). *

• Haarmann-Stemmann T, Bothe H, Abel J. Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem. Pharmacol. 77: 508-520 (2009). *

• Hagiwara S, Otsuka T, Yamazaki Y, Kosone T, Sohara N, Ichikawa T, Sato K, Kakizaki S, Takagi H, Mori M. Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. Liver Int. 28: 126-131 (2008). *

• Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY, Green J, Kim SJ. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 49: 190-198 (2001). *

• Hajdu M, Kopper L, Sebestyen A. Notch-regulation upon Dll4-stimulation of TGFb-induced apoptosis and gene expression in human B-cell non-Hodgkin lymphomas. Scand. J. Immunol. 71: 29-37 (2010). *

• Hakansson P, Nilsson B, Andersson A, Lassen C, Gullberg U, Fioretos T. Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation. Genes Chromosomes Cancer 47: 267-275 (2008).

• Hale LP, Perera D, Gottfried MR, Maggio-Price L, Srinivasan S, Marchuk D. Neonatal co-infection with Helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. Helicobacter 12: 598-604 (2007). *

• Hall BE, Zheng C, Swaim WD, Cho A, Nagineni CN, Eckhaus MA, Flanders KC, Ambudkar IS, Baum BJ, Kulkarni AB. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab. Invest. Feb 8 [Epub ahead of print] (2010). *

• Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 47: 79-87 (2000). *

• Ham SA, Kim HJ, Kim HJ, Kang ES, Eun SY, Kim GH, Park MH, Woo IS, Kim HJ, Chang KC, Lee JH, Seo HG. PPARdelta promotes wound healing by upregulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. J. Cell. Mol. Med. Jun 16 [Epub ahead of print] (2009). *

• Hameed DA, El-Metwally TH. The effectiveness of retinoic acid treatment in bladder cancer: impact on recurrence, survival and TGFalpha and VEGF as end-point biomarkers. Cancer Biol. Ther. 7: 92-100 (2008). *

• Hammaker DR, Boyle DL, Inoue T, Firestein GS. Regulation of the JNK pathway by TGF-beta activated kinase 1 (TAK1) in rheumatoid arthritis synoviocytes. Arthritis Res. Ther. 9: R57 (2007). *

• Hamzaoui K, Hamzaoui A, Houman H. CD4+CD25+ regulatory T cells in patients with Behcet's disease. Clin. Exp. Rheumatol. 24: S071-S078 (2006).

• Han G, Wang R, Chen G, Wang J, Xu R, Wang L, Feng J, Li X, Guo R, Fu L, Shen B, Li Y. Interleukin-17-producing gammadelta(+) T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology 129: 197-206 (2010). *

• Han G, Williams CA, Salter K, Garl PJ, Li AG, Wang XJ. A role for TGFbeta signaling in the pathogenesis of psoriasis. J. Invest. Dermatol. Aug 27 [Epub ahead of print] (2009). *

• Han GR, Dohi DF, Lee HY, Rajah R, Walsh GL, Hong WK, Cohen P, Kurie JM. All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway. J. Biol. Chem. 272: 13711-13716 (1997). *

• Han HS, Jun HS, Utsugi T, Yoon JW. Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice. J. Autoimmun. 10: 299-307 (1997).

• Han JY, Kim YJ, Kim L, Choi SJ, Park IS, Kim JM, Chu YC, Cha DR. PPARgamma agonist and angiotensin II receptor antagonist ameliorate renal tubulointerstitial fibrosis. J. Korean Med. Sci. 25: 35-41 (2010). *

• Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL, Roman E, Arima K, Wang YH, Voo KS, Cao W, Liu YJ. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of forkhead box P3+ regulatory T cells in human thymus. J. Immunol. Feb 19 [Epub ahead of print] (2010).

• Hanai J. BMP in the kidney : signaling, function and pathophysiological significance. Clin. Calcium 17: 704-710 (2007).

• Hanauer SB. Update on the etiology, pathogenesis and diagnosis of ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol. 1: 26-31 (2004). *

• Hansson T, Ulfgren AK, Lindroos E, DannAEus A, Dahlbom I, Klareskog L. Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Scand. J. Immunol. 56: 530-537 (2002). *

• Hao CM, Breyer MD. Roles of lipid mediators in kidney injury. Semin. Nephrol. 27: 338-351 (2007).

• Harada K, Sato Y, Ikeda H, Isse K, Ozaki S, Enomae M, Ohama K, Katayanagi K, Kurumaya H, Matsui A, Nakanuma Y. Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J. Pathol. 217: 654-664 (2009). *

• Harbige LS. Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Lipids 38: 323-341 (2003).

• Harbige LS. Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease. Proc. Nutr. Soc. 57: 555-562 (1998). *

• Harloff S, Hartwig D, Kasper K, Wedel T, Muller M, Geerling G. Epitheliotrophic capacity of serum eye drops from healthy donors versus serum from immunosuppressed patients with rheumatoid arthritis. Klin. Monatsbl. Augenheilkd. 225: 200-206 (2008).

• Harris WT, Muhlebach MS, Oster RA, Knowles MR, Noah TL. Transforming growth factor-beta(1) in bronchoalveolar lavage fluid from children with cystic fibrosis. Pediatr. Pulmonol. 44: 1057-1064 (2009).

• Harsha WT, Kalandarova E, McNutt P, Irwin R, Noel J. Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury. J. Pediatr. Gastroenterol. Nutr. 42: 53-58 (2006). *

• Hart AL, Kamm MA, Knight SC, Stagg AJ. Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls. Clin. Exp. Immunol. 135: 137-145 (2004). *

• Hart AL, Kamm MA, Knight SC, Stagg AJ. Prospective evaluation of intestinal homing memory T cells in ulcerative colitis. Inflamm. Bowel Dis. 10: 496-503 (2004). *

• Hartman C, Berkowitz D, Weiss B, Shaoul R, Levine A, Adiv OE, Shapira R, Fradkin A, Wilschanski M, Tamir A, Shamir R. Nutritional supplementation with polymeric diet enriched with transforming growth factor-beta 2 for children with Crohn's disease. Isr. Med. Assoc. J. 10: 503-507 (2008). *

• Hasegawa M, Sato S, Takehara K. Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. Arch. Dermatol. Res. 296: 89-93 (2004). *

• Hassan M, Selimovic D, Ghozlan H, Abdel-Kader O. Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways. Hepatology 49: 1469-1482 (2009).

• Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama K, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A. Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma. Clin. Exp. Allergy 37: 1165-1174 (2007). *

• Hatta K, Morimoto A, Ishii E, Kimura H, Ueda I, Hibi S, Todo S, Sugimoto T, Imashuku S. Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases. Haematologica 92: 1470-1474 (2007). *

• Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC. Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro. Gastroenterology 131: 194-209 (2006). *

• Havasi V, Rowe SM, Kolettis PN, Dayangac D, Ahmet Sahin, Grangeia A, Carvalho F, Barros A, Sousa M, Bassas L, Casals T, Sorscher EJ. Association of cystic fibrosis genetic modifiers with congenital bilateral absence of the vas deferens. Fertil. Steril. Jan 23 [Epub ahead of print] (2010). *

• Haveri H, Ashorn M, Iltanen S, Wilson DB, Andersson LC, Heikinheimo M. Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J. Clin. Immunol. 29: 444-453 (2009). *

• Hayashi H, Beppu T, Sugita H, Masuda T, Okabe H, Takamori H, Baba H. Serum HGF and TGF-beta1 levels after right portal vein embolization. Hepatol. Res. Jan 4 [Epub ahead of print] (2010). *

• Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S. Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats. J. Pharmacol. Exp. Ther. 326: 523-531 (2008). *

• Hayes CE. Vitamin D: a natural inhibitor of multiple sclerosis. Proc. Nutr. Soc. 59: 531-535 (2000). *

• He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc. Natl. Acad. Sci. U.S.A. 40: 15817-15822 (2007). *

• He W, Liu Q, Wang L, Chen W, Li N, Cao X. TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol. Immunol. 44: 2850-2859 (2007). *

• Heino TJ, Hentunen TA, Vaananen HK. Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen. J. Cell. Biochem. 85: 185-197 (2002). *

• Heinrich S, Jochum W, Graf R, Clavien PA. Portal vein ligation and partial hepatectomy differentially influence growth of intrahepatic metastasis and liver regeneration in mice. J. Hepatol. 45: 35-42 (2006). *

• Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 113: 2301-2312 (2006).

• Hellings PW, Vandenberghe P, Kasran A, Coorevits L, Overbergh L, Mathieu C, Ceuppens JL. Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice. Eur. J. Immunol. 32: 585-594 (2002). *

• Helliwell C. Immunology primer. Immunology news: a new type of T cell is discovered (http://www.acnr.co.uk/JF07/ACNR_JF07_immunology.pdf). ACNR 6: 8-9 (2007). *

• Hennig M, Yip-Schneider MT, Wentz S, Wu H, Hekmatyar SK, Klein P, Bansal N, Schmidt CM. Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systems. Hepatology Nov 30 [Epub ahead of print] (2009). *

• Herbert DR, Orekov T, Perkins C, Finkelman FD. IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis. J. Immunol. 181: 7214-7220 (2008). *

• Hering NA, Schulzke JD. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis. 27: 450-454 (2009).

• Herrada AA, Contreras FJ, Marini NP, Amador CA, Gonzalez PA, Cortes CM, Riedel CA, Carvajal CA, Figueroa F, Michea LF, Fardella CE, Kalergis AM. Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity. J. Immunol. 184: 191-202 (2010).

• Herzer K, Ganten TM, Schulze-Bergkamen H, Grosse-Wilde A, Koschny R, Krammer PH, Walczak H. Transforming growth factor beta can mediate apoptosis via the expression of TRAIL in human hepatoma cells. Hepatology 42: 183-192 (2005). *

• Heul-Nieuwenhuijsen LV, Dits N, Van Ijcken W, de Lange D, Jenster G. The FOXF2 pathway in the human prostate stroma. Prostate 69: 1538-1547 (2009).

• Heydemann A, Ceco E, Lim JE, Hadhazy M, Ryder P, Moran JL, Beier DR, Palmer AA, McNally EM. Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice. J. Clin. Invest. 119: 3703-3712 (2009). *

• Higashimoto Y, Yamagata Y, Taya S, Iwata T, Okada M, Ishiguchi T, Sato H, Itoh H. Systemic inflammation in chronic obstructive pulmonary disease and asthma: similarities and differences. Respirology 13: 128-133 (2008).

• Hilchey SP, De A, Rimsza LM, Bankert RB, Bernstein SH. Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells. J. Immunol. 178: 4051-4061 (2007). *

• Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27: 786-800 (2007). *

• Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4(+)CD44(hi) cells. Immunity 29: 758-770 (2008). *

• Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA. A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J. Immunol. 177: 7820-7832 (2006). *

• Hillian AD, Londono D, Dunn JM, Goddard KA, Pace RG, Knowles MR, Drumm ML. Modulation of cystic fibrosis lung disease by variants in interleukin-8. Genes Immun. 9: 501-508 (2008).

• Hilliard TN, Regamey N, Shute J, Nicholson A, Alton EW, Bush A, Davies JC. Airway remodelling in children with cystic fibrosis. Thorax 62: 1074-1080 (2007).

• Hillyer L, Dao B, Niemiec P, Lee S, Doidge M, Bemben I, Neyestani T, Woodward B. Elevated bioactivity of the tolerogenic cytokines, interleukin-10 and transforming growth factor-beta, in the blood of acutely malnourished weanling mice. Exp. Biol. Med. (Maywood) 231: 1439-1447 (2006). *

• Hines IN, Kremer M, Isayama F, Perry AW, Milton RJ, Black AL, Byrd CL, Wheeler MD. Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis. Hepatology 46: 229-241 (2007). *

• Hiramatsu K, Matsumoto Y, Miyazaki M, Tsubouchi H, Yamamoto I, Gohda E. Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid. Biol. Pharm. Bull. 28: 619-624 (2005). *

• Hirohata S, Shibuya H, Tejima S. Suppressive influences of IFN-alpha on IL-17 expression in human CD4+ T cells. Clin. Immunol. Dec 14 [Epub ahead of print] (2009). *

• Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204: 2803-2812 (2007). *

• Hisamori S, Tabata C, Kadokawa Y, Okoshi K, Tabata R, Mori A, Nagayama S, Watanabe G, Kubo H, Sakai Y. All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production. Liver Int. 28: 1217-1225 (2008). *

• Ho J, Kurtz CC, Naganuma M, Ernst PB, Cominelli F, Rivera-Nieves J. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J. Immunol. 180: 2573-2580 (2008). *

• Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. 158: 1958-1962 (1998). *

• Hoberg M, Rudert M, Pap T, Klein G, Gay S, Aicher WK. Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts. Ann. Rheum. Dis. 66: 446-451 (2007). *

• Hoentjen F, Welling GW, Harmsen HJ, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm. Bowel Dis. 11: 977-985 (2005). *

• Hoff NP, Degrandi D, Hengge U, Pfeffer K, Wurthner JU. Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus. J. Clin. Immunol. 27: 568-579 (2007). *

• Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF Jr, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J. Allergy Clin. Immunol. 113: 511-518 (2004). *

• Hoffmann JC, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M, Kuhl AA. gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Int. J. Colorectal Dis. 23: 909-920 (2008). *

• Hoffmann P, Reinshagen M, Zeeh JM, Lakshmanan J, Wu VS, Goebell H, Gerken G, Eysselein VE. Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats. Scand. J. Gastroenterol. 35: 1174-1180 (2000). *

• Holm AM, Aukrust P, Damas JK, Muller F, Halvorsen B, Froland SS. Abnormal interleukin-7 function in common variable immunodeficiency. Blood 105: 2887-2890 (2005). *

• Holtta V, Klemetti P, Sipponen T, Westerholm-Ormio M, Kociubinski G, Salo H, Rasanen L, Kolho KL, Farkkila M, Savilahti E, Vaarala O. IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm. Bowel Dis. 14: 1175-1184 (2008). *

• Holzer U, Rieck M, Buckner JH. Lineage and signal strength determine the inhibitory effect of transforming growth factor beta1 (TGF-beta1) on human antigen-specific Th1 and Th2 memory cells. J. Autoimmun. 26: 241-251 (2006).

• Homann D, Eisenbarth GS. An immunologic homunculus for type 1 diabetes. J. Clin. Invest. 116: 1212-1215 (2006). *

• Hong J, Li N, Zhang X, Zheng B, Zhang JZ. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc. Natl. Acad. Sci. U.S.A. 102: 6449-6454 (2005). *

• Hong JH, Lee GT, Lee JH, Kwon SJ, Park SH, Kim SJ, Kim IY. Effect of bone morphogenetic protein-6 on macrophages. Immunology 128: e442-e450 (2009). *

• Hong KM, Belperio JB, Keane MP, Burdick MD, Strieter RM. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator activated receptor-gamma. J. Biol. Chem. 282: 22910-22920 (2007). *

• Hong S, Lim S, Li AG, Lee C, Lee YS, Lee EK, Park SH, Wang XJ, Kim SJ. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat. Immunol. 8: 504-513 (2007). *

• Hoover LL, Burton EG, O'Neill ML, Brooks BA, Sreedharan S, Dawson NA, Kubalak SW. Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. Biochim. Biophys. Acta 1783: 2279-2286 (2008). *

• Hormi K, Cadiot G, Kermorgant S, Dessirier V, Le Romancer M, Lewin MJ, Mignon M, Lehy T. Transforming growth factor-alpha and epidermal growth factor receptor in colonic mucosa in active and inactive inflammatory bowel disease. Growth Factors 18: 79-91 (2000).

• Horst OV, Tompkins KA, Coats SR, Braham PH, Darveau RP, Dale BA. TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria. J. Dent. Res. 88: 333-338 (2009).

• Horst-Sikorska W, Wawrzyniak A, Celczynska-Bajew L, Marcinkowska M, Dabrowski S, Kalak R, Slomski R. Polymorphism of VDR gene - the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland. Endokrynol. Pol. 56: 233-239 (2005).

• Horwitz DA, Zheng SG, Gray JD. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 29: 429-435 (2008). *

• Horwitz DA, Zheng SG, Wang J, Gray JD. Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3(+)CD4(+) Treg. Eur. J. Immunol. 38: 912-915 (2008). *

• Hotz B, Visekruna A, Buhr HJ, Hotz HG. Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. J. Gastrointest. Surg. Oct 24 [Epub ahead of print] (2009). *

• Hou X, Arvisais EW, Jiang C, Chen DB, Roy SK, Pate JL, Hansen TR, Rueda BR, Davis JS. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol. Endocrinol. 22: 403-414 (2008). *

• Hougardy JM, Place S, Hildebrand M, Drowart A, Debrie AS, Locht C, Mascart F. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am. J. Respir. Crit. Care Med. 176: 409-416 (2007). *

• Houot R, Perrot I, Garcia E, Durand I, Lebecque S. Human CD4+CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation. J. Immunol. 176: 5293-5398 (2006). *

• Howe HS, Zhao L, Song YW, Springer L, Edmonds J, Gu J, Yu DT. Seronegative spondyloarthropathy - studies from the Asia Pacific region. Ann. Acad. Med. Singapore 36: 135-141 (2007). *

• Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. Am. J. Pathol. 167: 1587-1597 (2005). *

• Howe KL, Wang A, Hunter MM, Stanton BA, McKay DM. TGFbeta down-regulation of the CFTR: a means to limit epithelial chloride secretion. Exp. Cell Res. 298: 473-484 (2004). *

• Hrckova G, Velebny S, Solar P. Dynamics of hepatic stellate cells, collagen types I and III synthesis and gene expression of selected cytokines during hepatic fibrogenesis following Mesocestoides vogae (Cestoda) infection in mice. Int. J. Parasitol. Jul 22 [Epub ahead of print] (2009). *

• Hrycek A, Janowska J, Cieslik P. Selected angiogenic cytokines in systemic lupus erythematosus patients. Autoimmunity 42: 459-466 (2009).

• Hrycek A, Siekiera U, Cieslik P, Szkrobka W. HLA-DRB1 and -DQB1 alleles and gene polymorphisms of selected cytokines in systemic lupus erythematosus. Rheumatol. Int. 26: 1-6 (2005). *

• Hryniewicz A, Boasso A, Edghill-Smith Y, Vaccari M, Fuchs D, Venzon D, Nacsa J, Betts MR, Tsai WP, Heraud JM, Beer B, Blanset D, Chougnet C, Lowy I, Shearer GM, Franchini G. CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood 108: 3834-3842 (2006). *

• Hsieh CS, Huang CC, Wu JJ, Chaung HC, Wu CL, Chang NK, Chang YM, Chou MH, Chuang JH. Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. J. Pediatr. Surg. 36: 1623-1628 (2001).

• Hsu TC, Tzang BS, Huang CN, Lee YJ, Liu GY, Chen MC, Tsay GJ. Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells. Clin. Exp. Immunol. 144: 152-157 (2006). *

• Hsu WT, Suen JL, Chiang BL. The role of CD4CD25 T cells in autoantibody production in murine lupus. Clin. Exp. Immunol. 145: 513-519 (2006). *

• Hu BC, Chu SL, Wang GL, Gao PJ, Zhu DL, Wang JG. Association between genetic variation in transforming growth factors beta1 and beta3 and renal dysfunction in non-diabetic Chinese. Clin. Exp. Hypertens. 30: 121-131 (2008).

• Hu YW, Wang Q, Ma X, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK. TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. J. Atheroscler. Thromb. Jan 7 [Epub ahead of print] (2010). *

• Huang L, Wei MF, Feng JX. Abnormal activation of OPN inflammation pathway in livers of children with biliary atresia and relationship to hepatic fibrosis. Eur. J. Pediatr. Surg. 18: 224-229 (2008).

• Huang MC, Liao JJ, Bonasera S, Longo DL, Goetzl EJ. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 22: 2142-2150 (2008). *

• Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ. Human CD4-8- T cells are a distinctive immunoregulatory subset. FASEB J. Feb 12 [Epub ahead of print] (2010). *

• Huang QY, Li GH, Cheung WM, Song YQ, Kung AW. Prediction of osteoporosis candidate genes by computational disease-gene identification strategy. J. Hum. Genet. 53: 644-655 (2008). *

• Huang QY, Li GH, Kung AW. The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Bone 45: 289-294 (2009). *

• Huang YH, Zozulya AL, Weidenfeller C, Schwab N, Wiendl H. T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible. J. Leukoc. Biol. 86: 273-281 (2009). *

• Huang YT, Hsu YC, Chen CJ, Liu CT, Wei YH. Oxidative-stress-related changes in the livers of bile-duct-ligated rats. J. Biomed. Sci. 10: 170-178 (2003). *

• Hubacek AJ, Weichetova M, Bohuslavova R, Skodova Jan Z, Adamkova V. Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females. Endocr. Regul. 40: 77-81 (2006). *

• Hubacek JA, Weichetova M, Bohuslavova R, Skodova Z, Stepan JJ, Adamkova V. No associations between genetic polymorphisms of TGFss, PAI-1, and COL1A1, and bone mineral density in Caucasian females. Endocr. Regul. 40: 107-112 (2006). *

• Huber M, Brustle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Low E, Lohoff M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc. Natl. Acad. Sci. U.S.A. 105: 20846-20851 (2008). *

• Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hunig T, Mittrucker HW, Brustle A, Kamradt T, Lohoff M. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur. J. Immunol. 39: 1716-1725 (2009). *

• Huber M, Steinwald V, Guralnik A, Brustle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M. IL-27 inhibits the development of regulatory T cells via STAT3. Int. Immunol. 20: 223-234 (2008). *

• Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114: 569-581 (2004). *

• Huber S, Stahl FR, Schrader J, Luth S, Presser K, Carambia A, Flavell RA, Werner S, Blessing M, Herkel J, Schramm C. Activin A promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells. J. Immunol. 182: 4633-4640 (2009).

• Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Batge B, Notbohm H, Reinhardt DP. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria. J. Biol. Chem. 280: 34946-34955 (2005). *

• Huh S, Lee K, Yun HS, Paik DJ, Kim JM, Youn J. Functions of metallothionein generating interleukin-10-producing regulatory CD4+ T cells potentiate suppression of collagen-induced arthritis. J. Microbiol. Biotechnol. 17: 348-358 (2007).

• Huibregtse IL, Marietta EV, Rashtak S, Koning F, Rottiers P, David CS, van Deventer SJ, Murray JA. Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic Abo Dq8 transgenic mice. J. Immunol. 183: 2390-2396 (2009).

• Huibregtse IL, Snoeck V, de Creus A, Braat H, De Jong EC, Van Deventer SJ, Rottiers P. Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin. Gastroenterology 133: 517-528 (2007). *

• Hultkrantz S, Ostman S, Telemo E. Induction of antigen-specific regulatory T cells in the liver-draining celiac lymph node following oral antigen administration. Immunology 116: 362-372 (2005). *

• Hume GE, Fowler EV, Lincoln D, Eri R, Templeton D, Florin TH, Cavanaugh JA, Radford-Smith GL. Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease. J. Med. Genet. 43: e51 (2006). *

• Hummelshoj L, Ryder LP, Nielsen LK, Nielsen CH, Poulsen LK. Class switch recombination in selective IgA-deficient subjects. Clin. Exp. Immunol. 144: 458-466 (2006). *

• Hummelshoj L, Ryder LP, Poulsen LK. The role of the interleukin-10 subfamily members in immunoglobulin production by human B cells. Scand. J. Immunol. 64: 40-47 (2006). *

• Huntington ND, Tomioka R, Clavarino C, Chow AM, Linares D, Mana P, Rossjohn J, Cachero TG, Qian F, Kalled SL, Bernard CC, Reid HH. A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int. Immunol. 18: 1473-1485 (2006). *

• Hunzelmann N, Brinckmann J. What are the new milestones in the pathogenesis of systemic sclerosis? Ann. Rheum. Dis. 69 Suppl. 1: i52-i56 (2010).

• Huter EN, Punkosdy GA, Glass DD, Cheng LI, Ward JM, Shevach EM. TGF-beta-induced Foxp3(+) regulatory T cells rescue scurfy mice. Eur. J. Immunol. 38: 1814-1821 (2008). *

• Huter EN, Stummvoll GH, Dipaolo RJ, Glass DD, Shevach EM. Cutting edge: antigen-specific TGFbeta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J. Immunol. 181: 8209-8213 (2008). *

• Huter EN, Stummvoll GH, Dipaolo RJ, Glass DD, Shevach EM. Pre-differentiated Th1 and Th17 effector T cells in autoimmune gastritis: Ag-specific regulatory T cells are more potent suppressors than polyclonal regulatory T cells. Int. Immunopharmacol. 9: 540-545 (2009).

• Huurre A, Laitinen K, Rautava S, Korkeamaki M, Isolauri E. Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. Clin. Exp. Allergy 38: 1342-1348 (2008). *

• Hwang SA, Actor JK. Lactoferrin modulation of BCG-infected dendritic cell functions. Int. Immunol. 21: 1185-1197 (2009).

• Hyun JG, Barrett TA. Oral tolerance therapy in inflammatory bowel disease. Am. J. Gastroenterol. 101: 569-571 (2006). *

• Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, Yamada A, Kato T, Izawa H, Murohara T, Yokota M. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J. Mol. Cell. Cardiol. 41: 318-329 (2006).

• Ichinose K, Kawasaki E, Eguchi K. Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy. Am. J. Nephrol. 27: 554-564 (2007). *

• Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Moroy T, Yoshimura A. Gfi1 negatively regulates Th17 differentiation by inhibiting RORgammat activity. Int. Immunol. 21: 881-889 (2009). *

• Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgamma t-mediated IL-17A mRNA transcription through direct interaction with RORgamma t. J. Biol. Chem. 283: 17003-17008 (2008). *

• Icre G, Wahli W, Michalik L. Functions of the peroxisome proliferator-activated receptor (PPAR) alpha and beta in skin homeostasis, epithelial repair, and morphogenesis. J. Investig. Dermatol. Symp. Proc. 11: 30-35 (2006).

• Ido A, Numata M, Kodama M, Tsubouchi H. Mucosal repair and growth factors: recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease. J. Gastroenterol. 40: 925-931 (2005). *

• Ifergan I, Kebir H, Bernard M, Wosik K, Dodelet-Devillers A, Cayrol R, Arbour N, Prat A. The blood brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 131: 785-799 (2008).

• Ihm CG, Jeong KW, Lee SH, Lee TW, Park JK. Effects of therapeutic agents on the inflammatory and fibrogenic factors in IgA nephropathy. Nephrology (Carlton) 12 Suppl. 3: S25-S26 (2007).

• Ihm SH, Chang K, Kim HY, Baek SH, Youn HJ, Seung KB, Kim JH. Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor. Basic Res. Cardiol. Oct 23 [Epub ahead of print] (2009).

• Ikeda H, Inao M, Fujiwara K. Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells. Biochem. Biophys. Res. Commun. 227: 322-327 (1996). *

• Ikeda M, Takeshima F, Ohba K, Ohnita K, Isomoto H, Yamakawa M, Omagari K, Mizuta Y, Kohno S. Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4+ CD25+ T cells of patients with inflammatory bowel disease. Dig. Dis. Sci. 51: 178-184 (2006). *

• Ikegami T. Transforming growth factor-beta signaling and liver cancer stem cell. Hepatol. Res. 39: 847-849 (2009). *

• Ilan Y, Weksler-Zangen S, Ben-Horin S, Diment J, Sauter B, Rabbani E, Engelhardt D, Chowdhury NR, Chowdhury JR, Goldin E. Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes. Am. J. Gastroenterol. 95: 966-973 (2000). *

• Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent Immunologic effect in T cells and dendritic cells. J. Clin. Immunol. Sep 16 [Epub ahead of print] (2009). *

• Iliev ID, Mileti E, Matteoli G, Chieppa M, Rescigno M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2: 340-350 (2009). *

• Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, Foschi D, Caprioli F, Viale G, Rescigno M. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58: 1481-1489 (2009).

• Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H. Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology 128: 138-146 (2005). *

• Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J. TAK1 binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J. Biol. Chem. 283: 33080-33086 (2008). *

• Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J. Immunol. 173: 1390-1398 (2004). *

• Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Suppressor of cytokine signalling-1 in lymphocytes regulates the development of intestinal inflammation in mice. Gut 55: 212-219 (2006). *

• Ince MN, Elliott DE, Setiawan T, Blum A, Metwali A, Wang Y, Urban JF Jr, Weinstock JV. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation. J. Immunol. 176: 726-729 (2006). *

• Ince MN, Elliott DE, Setiawan T, Metwali A, Blum A, Chen HL, Urban JF, Flavell RA, Weinstock JV. Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. Eur. J. Immunol. 39: 1870-1878 (2009). *

• Incorvaia C, Frati F, Puccinelli P, Marcucci F, Di Cara G, Sensi L, Scurati S, Yacoub MR, Moingeon P. Effects of sublingual immunotherapy on allergic inflammation. Inflamm. Allergy Drug Targets 7: 167-172 (2008).

• Inoue S, Imamura M, Umezawa A, Tabata Y. Attachment, proliferation and adipogenic differentiation of adipo-stromal cells on self-assembled monolayers of different chemical compositions. J. Biomater. Sci. Polym. Ed. 19: 893-914 (2008).

• Invernizzi P, Gershwin ME. The genetic basis of primary biliary cirrhosis: premises, not promises. Gastroenterology 135: 1044-1047 (2008). *

• Iosub R, Klug J, Fijak M, Schneider E, Frohlich S, Blumbach K, Wennemuth G, Sommerhoff C, Steinhoff M, Meinhardt A. Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2. J. Pathol. 208: 686-698 (2006). *

• Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF, Yan C, Li JD. Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation. Biochem. J. 417: 583-591 (2009). *

• Ishizuka K, Sugimura K, Homma T, Matsuzawa J, Mochizuki T, Kobayashi M, Suzuki K, Otsuka K, Tashiro K, Yamaguchi O, Asakura H. Influence of interleukin-10 on the interleukin-1 receptor antagonist/interleukin-1 beta ratio in the colonic mucosa of ulcerative colitis. Digestion 63 Suppl. 1: 22-27 (2001).

• Ito H. IL-6 and Crohn's disease. Curr. Drug Targets Inflamm. Allergy 2: 125-30 (2003).

• Ito H. Anti-interleukin-6 therapy for Crohn's disease. Curr. Pharm. Des. 9: 295-305 (2003).

• Ito T, Hanabuchi S, Wang YH, Park WR, Arima K, Bover L, Qin FX, Gilliet M, Liu YJ. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity 28: 870-880 (2008). *

• Ito Y, Miyazono K. RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr. Opin. Genet. Dev. 13: 43-47 (2003). *

• Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4: 337-349 (2008). *

• Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17(+) T helper cells. Cell 126: 1121-1133 (2006). *

• Ivanov II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 19: 409-417 (2007). *

• Ivars F. Superantigen-induced regulatory T cells in vivo. Chem. Immunol. Allergy 93: 137-160 (2007).

• Ivory CP, Wallace LE, McCafferty DM, Sigalet DL. Interleukin-10 independent anti-inflammatory actions of glucagon-like peptide 2. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G1202-G1210 (2008). *

• Iwata Y, Yoshizaki A, Komura K, Shimizu K, Ogawa F, Hara T, Muroi E, Bae S, Takenaka M, Yukami T, Hasegawa M, Fujimoto M, Tomita Y, Tedder TF, Sato S. CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. Am. J. Pathol. 175: 649-660 (2009). *

• Izcue A, Coombes JL, Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212: 256-271 (2006). *

• Jaakkola E, Crane AM, Laiho K, Herzberg I, Sims AM, Bradbury L, Calin A, Brophy S, Kauppi M, Kaarela K, Wordsworth BP, Tuomilehto J, Brown MA. The effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis. Rheumatology (Oxford) 43: 32-38 (2004). *

• Jackson M, Ahmad Y, Bruce IN, Coupes B, Brenchley PE. Activation of transforming growth factor-beta1 and early atherosclerosis in systemic lupus erythematosus. Arthritis Res. Ther. 8: R81 (2006). *

• Jaen O, Rulle S, Bessis N, Zago A, Boissier MC, Falgarone G. Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo. Immunology 126: 35-44 (2009). *

• Jager M, Bachmann R, Scharfstadt A, Krauspe R. Ovine cord blood accommodates multipotent mesenchymal progenitor cells. In Vivo 20: 205-214 (2006).

• Jahromi MM, Millward BA, Demaine AG. Significant correlation between association of polymorphism in codon 10 of the transforming growth factor-beta1 T (29) C with type 1 diabetes and patients with nephropathy disorder. J. Interferon Cytokine Res. Dec 29 [Epub ahead of print] (2009).

• Jain N, Nguyen H, Friedline RH, Malhotra N, Brehm M, Koyanagi M, Bix M, Cooper JA, Chambers CA, Kang J. Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. J. Immunol. 183: 4192-4196 (2009).

• Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S. The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. Eur. J. Immunol. 39: 2571-2583 (2009). *

• Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310: 1646-1653 (2005). *

• Janke M, Peine M, Nass A, Morawietz L, Hamann A, Scheffold A. In vitro-induced Th17 cells fail to induce inflammation in vivo and show an impaired migration into inflamed sites. Eur. J. Immunol. Jan 25 [Epub ahead of print] (2010). *

• Janson PC, Winerdal ME, Marits P, Thorn M, Ohlsson R, Winqvist O. FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS ONE 3: e1612 (2008). *

• Jarnicki AG, Lysaght J, Todryk S, Mills KH. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J. Immunol. 177: 896-904 (2006). *

• Jarrar MH, Baranova A. PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling. J. Cell. Mol. Med. 11: 71-87 (2007). *

• Jarry A, Bossard C, Bou-Hanna C, Masson D, Espaze E, Denis MG, Laboisse CL. Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants. J. Clin. Invest. 118: 1132-1142 (2008). *

• Jaskiewicz K, Voigt H, Blakolmer K. Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy. J. Toxicol. Clin. Toxicol. 34: 301-305 (1996).

• Javed A, Afzal F, Bae JS, Gutierrez S, Zaidi K, Pratap J, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs 189: 133-137 (2009). *

• Javor J, Bucova M, Ferencik S, Grosse-Wilde H, Buc M. Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population. Int. J. Immunogenet. 34: 273-280 (2007). *

• Javor J, Chmurova N, Parnicka Z, Ferencik S, Grosse-Wilde H, Buc M, Svecova D. TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population. J. Eur. Acad. Dermatol. Venereol. 24: 65-68 (2010). *

• Jeevan A, Bonilla DL, McMurray DN. Expression of interferon-gamma and tumour necrosis factor-alpha messenger RNA does not correlate with protection in guinea pigs challenged with virulent Mycobacterium tuberculosis by the respiratory route. Immunology 128: e296-e305 (2009).

• Jelaska A, Korn JH. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum. 43: 2230-2239 (2000). *

• Jeong WI, Park O, Radaeva S, Gao B. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology 44: 1441-1451 (2006). *

• Jergens AE, Sonea IM, O'Connor AM, Kauffman LK, Grozdanic SD, Ackermann MR, Evans RB. Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal. Comp. Med. 59: 153-162 (2009).

• Jeronimo SM, Holst AK, Jamieson SE, Francis R, Martins DR, Bezerra FL, Ettinger NA, Nascimento ET, Monteiro GR, Lacerda HG, Miller EN, Cordell HJ, Duggal P, Beaty TH, Blackwell JM, Wilson ME. Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection. Genes Immun. 8: 539-551 (2007). *

• Jia JD, Bauer M, Cho JJ, Ruehl M, Milani S, Boigk G, Riecken EO, Schuppan D. Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1. J. Hepatol. 35: 392-398 (2001). *

• Jiang T, Wang XX, Scherzer P, Wilson P, Tallman J, Takahashi H, Li J, Iwahashi M, Sutherland E, Arend L, Levi M. Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy. Diabetes 56: 2485-2493 (2007). *

• Jiao ZM, Fu YH, Fu J, Zhang F, Wang WZ. 1,25-Dihydroxyvitamin D3 promotes the apoptosis of inflammatory cells in acute experimental autoimmune encephalomyelitis:experiment with rats. Zhonghua Yi Xue Za Zhi 88: 2350-2354 (2008).

• Jin Y, Fuller L, Esquenazi V, Blomberg BB, Burke GW 3rd, Ciancio G, Tzakis AG, Ricordi C, Miller J. Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells. Immunol. Invest. 36: 213-232 (2007). *

• Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J. Biol. Chem. 279: 29409-29417 (2004). *

• Jinawath N, Chamgramol Y, Furukawa Y, Obama K, Tsunoda T, Sripa B, Pairojkul C, Nakamura Y. Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma. Hepatology 44: 1025-1038 (2006). *

• Jinnin M, Ihn H, Tamaki K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol. Pharmacol. 69: 597-607 (2006). *

• Jinushi M, Takehara T, Tatsumi T, Yamaguchi S, Sakamori R, Hiramatsu N, Kanto T, Ohkawa K, Hayashi N. Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology 120: 73-82 (2007). *

• Jirillo E, Amati L, Suppressa P, Cirimele D, Guastamacchia E, Covelli V, Tafaro E, Sabba C. Involvement of the transforming growth factor beta in the pathogenesis of hereditary hemorrhagic telangiectasia. Curr. Pharm. Des. 12: 1195-1200 (2006).

• Joetham A, Takeda K, Okamoto M, Taube C, Matsuda H, Dakhama A, Gelfand EW. Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells. J. Immunol. 183: 1821-1827 (2009).

• Jones KL, Mansell A, Patella S, Scott BJ, Hedger MP, de Kretser DM, Phillips DJ. Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc. Natl. Acad. Sci. U.S.A. 104: 16239-16244 (2007). *

• Jones LK, O'Sullivan KM, Semple T, Kuligowski MP, Fukami K, Ma FY, Nikolic-Paterson DJ, Holdsworth SR, Kitching AR. IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis. Nephrol. Dial. Transplant. 24: 3024-3032 (2009).

• Jonth AC, Silveira L, Fingerlin TE, Sato H, Luby JC, Welsh KI, Rose CS, Newman LS, du Bois RM, Maier LA; ACCESS Group. TGF-beta 1 variants in chronic beryllium disease and sarcoidosis. J. Immunol. 179: 4255-4262 (2007). *

• Jonuleit H, Adema G, Schmitt E. Immune regulation by regulatory T cells: implications for transplantation. Transpl. Immunol. 11: 267-276 (2003).

• Josefowicz SZ, Wilson CB, Rudensky AY. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J. Immunol. 182: 6648-6652 (2009).

• Joung CI, Park YW, Kim SK, Uhm WS, Kim TH, Yoo DH. Angiotensin-converting enzyme gene insertion/deletion polymorphism in Korean patients with systemic sclerosis. J. Korean Med. Sci. 21: 329-332 (2006). *

• Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J. Immunol. 160: 3513-3521 (1998). *

• Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology 126: 654-659 (2004). *

• Jung BH, Beck SE, Cabral J, Chau E, Cabrera BL, Fiorino A, Smith EJ, Bocanegra M, Carethers JM. Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. Gastroenterology 132: 633-644 (2007). *

• Jung S, Park YK, Lee H, Shin JH, Lee GR, Park SH. TGF-beta-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses. Exp. Mol. Med. Feb 11 [Epub ahead of print] (2010).

• Jung SA, Chung YH, Park NH, Lee SS, Kim JA, Yang SH, Song IH, Lee YS, Suh DJ, Moon IH. Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcohol. Scand. J. Gastroenterol. 35: 969-975 (2000). *

• Juszczak M, Glabinski A. Th17 cells in the pathogenesis of multiple sclerosis. Postepy. Hig. Med. Dosw. (Online) 63: 492-501 (2009).

• Kabelitz D, Wesch D, Oberg HH. Regulation of regulatory T cells: role of dendritic cells and Toll-like receptors. Crit. Rev. Immunol. 26: 291-306 (2006).

• Kader HA, Tchernev VT, Satyaraj E, Lejnine S, Kotler G, Kingsmore SF, Patel DD. Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease. Am. J. Gastroenterol. 100: 414-423 (2005). *

• Kader M, Bixler S, Piatak M, Lifson J, Mattapallil JJ. Anti-retroviral therapy fails to restore the severe Th-17:Tc-17 imbalance observed in peripheral blood during simian immunodeficiency virus infection. J. Med. Primatol. 38 Suppl. 1: 32-38 (2009).

• Kader M, Bixler S, Roederer M, Veazey R, Mattapallil JJ. CD4 T cell subsets in the mucosa are CD28Ki-67HLA-DRCD69 but show differential infection based on alpha4beta7 receptor expression during acute SIV infection. J. Med. Primatol. 38 Suppl. 1: 24-31 (2009).

• Kadunce DP, Krueger GG. Pathogenesis of psoriasis. Dermatol. Clin. 13: 723-737 (1995).

• Kagami SI, Owada T, Kanari H, Saito Y, Suto A, Ikeda K, Hirose K, Watanabe N, Iwamoto I, Nakajima H. Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. Int. Immunol. 21: 679-689 (2009).

• Kagnoff MF. Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1. Gastroenterology 132: 1174-1176 (2007). *

• Kaieda S, Tomi C, Oki S, Yamamura T, Miyake S. Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum. 56: 1836-1845 (2007). *

• Kajikawa S, Harada T, Kawashima A, Imada K, Mizuguchi K. Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of D-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet. Biochim. Biophys. Acta 1791: 281-288 (2009). *

• Kajikawa S, Harada T, Kawashima A, Imada K, Mizuguchi K. Highly purified eicosapentaenoic acid ethyl ester prevents development of steatosis and hepatic fibrosis in rats. Dig. Dis. Sci. Oct 24 [Epub ahead of print] (2009). *

• Kaklamani VG, Sadim M, Koumantaki Y, Kaklamanis P, Pasche B. Role of polymorphisms in Adamantiades-Behcet's disease. J. Rheumatol. 35: 2376-2378 (2008).

• Kalantari F, Miao D, Emadali A, Tzimas GN, Goltzman D, Vali H, Chevet E, Auguste P. Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation. Mod. Pathol. 20: 357-366 (2007). *

• Kalkan T, Iwasaki Y, Park CY, Thomsen GH. TRAF4 is a positive regulator of TGFbeta signaling that affects neural crest formation. Mol. Biol. Cell 20: 3436-3450 (2009). *

• Kallimanis PG, Xenos K, Markantonis SL, Stavropoulos P, Margaroni G, Katsambas A, Avgerinou G. Serum levels of transforming growth factor-beta1 in patients with mild psoriasis vulgaris and effect of treatment with biological drugs. Clin. Exp. Dermatol. 34: 582-586 (2009). *

• Kamradt T, Goggel R, Erb KJ. Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection. Trends Immunol. 26: 260-267 (2005). *

• Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T. Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr. Opin. Gastroenterol. 25: 306-313 (2009). *

• Kanauchi O, Oshima T, Andoh A, Shioya M, Mitsuyama K. Germinated barley foodstuff ameliorates inflammation in mice with colitis through modulation of mucosal immune system. Scand. J. Gastroenterol. 43: 1346-1352 (2008). *

• Kanazawa Y, Shimada A, Oikawa Y, Okubo Y, Tada A, Imai T, Miyazaki J, Itoh H. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. J. Autoimmun. 32: 104-109 (2009).

• Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L. Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J. Biol. Chem. 281: 4326-4333 (2006). *

• Kaneko M, Akiyama Y, Takimoto H, Kumazawa Y. Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide. Immunology 116: 64-70 (2005). *

• Kang HK, Datta SK. Regulatory T cells in lupus. Int. Rev. Immunol. 25: 5-25 (2006).

• Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J. Immunol. 178: 7849-7858 (2007). *

• Kang JH, Cho HJ, Lee IS, Kim M, Lee IK, Chang YC. Comparative proteome analysis of TGF-beta1-induced fibrosis processes in normal rat kidney interstitial fibroblast cells in response to ascofuranone. Proteomics 9: 4445-4456 (2009). *

• Kang S, Lee ES, Choi B, Lim HC, Chun M, Lee S, Sohn S. Effects of irradiation on cytokine production in a mouse model of Behcet's disease. Clin. Exp. Rheumatol. 27: 54-63 (2009).

• Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol. 179: 3724-3733 (2007). *

• Kang SS, Bloom SM, Norian LA, Geske MJ, Flavell RA, Stappenbeck TS, Allen PM. An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med. 5: e41 (2008). *

• Kania G, Blyszczuk P, Stein S, Valaperti A, Germano D, Dirnhofer S, Hunziker L, Matter CM, Eriksson U. Heart-infiltrating prominin-1+/CD133+ progenitor cells represent the cellular source of transforming growth factor beta-mediated cardiac fibrosis in experimental autoimmune myocarditis. Circ. Res. 105: 462-470 (2009).

• Kanjanabuch T, Ma LJ, Chen J, Pozzi A, Guan Y, Mundel P, Fogo AB. PPAR-gamma agonist protects podocytes from injury. Kidney Int. 71: 1232-1239 (2007). *

• Kanto T. Virus associated innate immunity in liver. Front. Biosci. 13: 6183-6192 (2008).

• Kanto T, Hayashi N. Innate immunity in hepatitis C virus infection: interplay among dendritic cells, natural killer cells and natural killer T cells. Hepatol. Res. 37 Suppl. 3: S319-S326 (2007).

• Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology Nov 17 [Epub ahead of print] (2009). *

• Kao YH, Chen CL, Jawan B, Chung YH, Sun CK, Kuo SM, Hu TH, Lin YC, Chan HH, Cheng KH, Wu DC, Goto S, Cheng YF, Chao D, Tai MH. Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis. J. Hepatol. 52: 96-105 (2010).

• Kapil P, Atkinson R, Ramakrishna C, Cua DJ, Bergmann CC, Stohlman SA. IL-12, but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control. J. Virol. 83: 5978-5986 (2009). *

• Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J. Exp. Med. 204: 2545-2552 (2007). *

• Kapoor M, McCann M, Liu S, Huh K, Denton CP, Abraham DJ, Leask A. Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum. 60: 2822-2829 (2009). *

• Karaa A, Thompson KJ, McKillop IH, Clemens MG, Schrum LW. S-Adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock 30: 197-205 (2008). *

• Karagiannidis C, Akdis M, Holopainen P, Woolley NJ, Hense G, Ruckert B, Mantel PY, Menz G, Akdis CA, Blaser K, Schmidt-Weber CB. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J. Allergy Clin. Immunol. 114: 1425-1433 (2004). *

• Karaoglan I, Pehlivan S, Namiduru M, Pehlivan M, Kilincarslan C, Balkan Y, Baydar I. TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis. New Microbiol. 32: 173-178 (2009).

• Karasu Z, Ulukaya S, Ayanoglu HO, Basturk B, Ulukaya E, Akyildiz M, Tokat Y. Cytokine gene polymorphism and early graft rejection in liver transplant recipients. Transplant. Proc. 36: 2791-2795 (2004).

• Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, Weber C, Merad M, Luedde T, Trautwein C, Tacke F. Hepatic recruitment of the inflammatory Gr1(+) monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50: 261-274 (2009).

• Karrar A, Broome U, Sodergren T, Jaksch M, Bergquist A, Bjornstedt M, Sumitran-Holgersson S. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 132: 1504-1514 (2007). *

• Karsdal MA, Larsen L, Engsig MT, Lou H, Ferreras M, Lochter A, Delaisse JM, Foged NT. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J. Biol. Chem. 277: 44061-44067 (2002). *

• Karumuthil-Melethil S, Perez N, Li R, Vasu C. Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes. J. Immunol. 181: 8323-8334 (2008). *

• Kasahara Y, Kaneko H, Fukao T, Terada T, Asano T, Kasahara K, Kondo N. Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminase. J. Allergy Clin. Immunol. 112: 755-760 (2003). *

• Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone Miner. 13: 235-250 (1991).

• Katagiri T, Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis. 8: 147-159 (2002). *

• Kato J, Ido A, Hasuike S, Uto H, Hori T, Hayashi K, Murakami S, Terano A, Tsubouchi H. Transforming growth factor-beta-induced stimulation of formation of collagen fiber network and anti-fibrotic effect of taurine in an in vitro model of hepatic fibrosis. Hepatol. Res. 30: 34-41 (2004).

• Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am. J. Pathol. 175: 1167-1177 (2009). *

• Kattah MG, Wong MT, Yocum MD, Utz PJ. Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells. Arthritis Rheum. 58: 1619-1629 (2008). *

• Kawada N. The hepatic perisinusoidal stellate cell. Histol. Histopathol. 12: 1069-1080 (1997).

• Kawaguchi Y, Ota Y, Kawamoto M, Ito I, Tsuchiya N, Sugiura T, Katsumata Y, Soejima M, Sato S, Hasegawa M, Fujimoto M, Takehara K, Kuwana M, Yamanaka H, Hara M. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. Ann. Rheum. Dis. 68: 1921-1924 (2009).

• Kawaguchi Y, Takagi K, Hara M, Fukasawa C, Sugiura T, Nishimagi E, Harigai M, Kamatani N. Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. Arthritis Rheum. 50: 216-226 (2004). *

• Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, Yorioka N. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab. Invest. 89: 47-58 (2009). *

• Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S. IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. Neoplasia 9: 1091-1098 (2007).

• Kayed H, Jiang X, Keleg S, Jesnowski R, Giese T, Berger MR, Esposito I, Lohr M, Friess H, Kleeff J. Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer. Br. J. Cancer 97: 1106-1115 (2007). *

• Keelan JA, Khan S, Yosaatmadja F, Mitchell MD. Prevention of inflammatory activation of human gestational membranes in an ex vivo model using a pharmacological NF-kappaB inhibitor. J. Immunol. 183: 5270-5278 (2009).

• Keino H, Watanabe T, Sato Y, Okada AA Dr. Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis. Br. J. Ophthalmol. Dec 3 [Epub ahead of print] (2009).

• Kekow J, Csernok E, Szymkowiak C, Gross WL. Interaction of transforming growth factor beta (TGF beta) with proteinase 3. Adv. Exp. Med. Biol. 421: 307-313 (1997).

• Keller CD, Rivera Gil P, Tolle M, van der Giet M, Chun J, Radeke HH, Schafer-Korting M, Kleuser B. Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am. J. Pathol. 170: 281-292 (2007). *

• Kelley TJ, Elmer HL, Corey DA. Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells. Am. J. Respir. Cell. Mol. Biol. 25: 732-738 (2001). *

• Kelsall BL. A focus on dendritic cells and macrophages as key regulators of mucosal immunity. Mucosal Immunol. 1: 423-424 (2008). *

• Kelsall BL, Leon F. Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease. Immunol. Rev. 206: 132-148 (2005). *

• Kempuraj D, Tagen M, Iliopoulou BP, Clemons A, Vasiadi M, Boucher W, House M, Wolfberg A, Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells. Br. J. Pharmacol. 155: 1076-1084 (2008). *

• Kershenobich Stalnikowitz D, Weissbrod AB. Liver fibrosis and inflammation. A review. Ann. Hepatol. 2: 159-163 (2003). *

• Kessel A, Ammuri H, Peri R, Pavlotzky ER, Blank M, Shoenfeld Y, Toubi E. Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function. J. Immunol. 179: 5571-5575 (2007). *

• Khalafi A, Schmid TM, Neu C, Reddi AH. Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors. J. Orthop. Res. 25: 293-303 (2007). *

• Khanna AK. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis. J. Biomed. Sci. 16: 66 (2009). *

• Khattar M, Chen W, Stepkowski SM. Expanding and converting regulatory T cells: a horizon for immunotherapy. Arch. Immunol. Ther. Exp. (Warsz.) 57: 199-204 (2009).

• Khil LY, Jun HS, Kwon H, Yoo JK, Kim S, Notkins AL, Yoon JW. Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice. Diabetologia 50: 2147-2155 (2007). *

• Khoo UY, Proctor IE, Macpherson AJ. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J. Immunol. 158: 3626-3634 (1997).

• Kikly K, Liu L, Na S, Sedgwick JD. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr. Opin. Immunol. 18: 670-675 (2006). *

• Kikuchi H, Katsuramaki T, Kukita K, Taketani S, Meguro M, Nagayama M, Isobe M, Mizuguchi T, Hirata K. New strategy for the antifibrotic therapy with oral administration of FR260330 (a selective inducible nitric oxide synthase inhibitor) in rat experimental liver cirrhosis. Wound Repair Regen. 15: 881-888 (2007). *

• Kikuchi K, Tanaka A, Matsushita M, Kitazawa E, Hosoya N, Kawashima Y, Selmi C, Gershwin ME, Miyakawa H. Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients. Ann. N. Y. Acad. Sci. 1110: 15-22 (2007). *

• Kilic ZM, Ayaz S, Ozin Y, Nadir I, Cakal B, Ulker A. Plasma transforming growth factor-beta1 level in inflammatory bowel disease. Turk. J. Gastroenterol. 20: 165-170 (2009). *

• Kim EY, Chi HH, Bouziane M, Gaur A, Moudgil KD. Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma. Clin. Immunol. 127: 98-106 (2008). *

• Kim EY, Moudgil KD. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol. Lett. 120: 1-5 (2008).

• Kim HA, Jeon SH, Seo GY, Park JB, Kim PH. TGF-beta1 and IFN-gamma stimulate mouse macrophages to express BAFF via different signaling pathways. J. Leukoc. Biol. 83: 1431-1439 (2008). *

• Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH. Photoprotective and anti-skin aging effects of eicosapentaenoic acid in human skin in vivo. J. Lipid Res. 47: 921-930 (2006). *

• Kim HJ, Andersson LC, Bouton D, Warner M, Gustafsson JA. Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 106: 558-563 (2009). *

• Kim HJ, Ham SA, Kim SU, Hwang JY, Kim JH, Chang KC, Yabe-Nishimura C, Kim JH, Seo HG. Transforming growth factor-beta1 is a molecular target for the peroxisome proliferator-activated receptor delta. Circ. Res. 102: 193-200 (2008). *

• Kim HJ, Hwang SJ, Kim BK, Jung KC, Chung DH. NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells. Immunology 118: 101-111 (2006). *

• Kim HJ, Kim MY, Jin H, Kim HJ, Kang SS, Kim HJ, Lee JH, Chang KC, Hwang JY, Yabe-Nishimura C, Kim JH, Seo HG. Peroxisome proliferator-activated receptor delta regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-beta1/Smad3. Circ. Res. 105: 16-24 (2009).

• Kim HY, Kim HJ, Min HS, Kim S, Park WS, Park SH, Chung DH. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. J. Exp. Med. 201: 41-47 (2005). *

• Kim HY, Kim S, Chung DH. FcgammaRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation. J. Clin. Invest. 116: 2484-2492 (2006). *

• Kim JJ, Choi YM, Choung SH, Yoon SH, Lee KS, Ku SY, Kim JG, Moon SY. Analysis of the transforming growth factor beta1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis. Fertil. Steril. Feb 25 [Epub ahead of print] (2009).

• Kim KK, Ji C, Chang W, Wells RG, Gundberg CM, McCarthy TL, Centrella M. Repetitive exposure to TGF-beta suppresses TGF-beta type I receptor expression by differentiated osteoblasts. Gene 379: 175- 84 (2006). *

• Kim KW, Cho ML, Park MK, Yoon CH, Park SH, Lee SH, Kim HY. Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis. Arthritis Res. Ther. 7: R139-R148 (2005). *

• Kim N, Yoo W, Lee J, Kim H, Lee H, Kim YS, Kim DU, Oh J. Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin. Gut 58: 1382-1390 (2009).

• Kim PH, Kagnoff MF. Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J. Immunol. 145: 3773-3778 (1990).

• Kim R, Emi M, Tanabe K. Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunity. Immunology 119: 254-264 (2006). *

• Kim S, Nadel JA. Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L174-L183 (2009). *

• Kim SG, Jeon CH, Suh HS, Choe JY, Shin IH. P-glycoprotein expression in extracellular matrix formation of chondrogenic differentiation of human adult stem cells. Cell Biol. Int. 31: 1042-1048 (2007). *

• Kim SH, Cheon HJ, Yun N, Oh ST, Shin E, Shim KS, Lee SM. Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis. J. Pharmacol. Sci. 109: 119-127 (2009). *

• Kim SH, Kim YK, Park HW, Jee YK, Kim SH, Bahn JW, Chang YS, Kim SH, Ye YM, Shin ES, Lee JE, Park HS, Min KU. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet. Genomics 17: 295-304 (2007).

• Kim SH, Park HS, Holloway JW, Shin HD, Park CS. Association between a TGFbeta1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patients. Respir. Med. 101: 490-495 (2007).

• Kim SH, Yang EM, Lee HN, Cho BY, Ye YM, Park HS. Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Allergy 64: 1221-1225 (2009). *

• Kim SM, Park KC, Kim HG, Han SJ. Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. Hepatol. Res. 38: 800-809 (2008). *

• Kim SY, Han SW, Kim GW, Lee JM, Kang YM. TGF-beta1 polymorphism determines the progression of joint damage in rheumatoid arthritis. Scand. J. Rheumatol. 33: 389-394 (2004).

• Kim WK, Lee CY, Kang MS, Kim MH, Ryu YH, Bae KH, Shin SJ, Lee SC, Ko Y. Effects of leptin on lipid metabolism and gene expression of differentiation-associated growth factors and transcription factors during differentiation and maturation of 3T3-L1 preadipocytes. Endocr. J. 55: 827-837 (2008). *

• Kim WU, Min SY, Cho ML, Hong KH, Shin YJ, Park SH, Cho CS. Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. Arthritis Res. Ther. 7: R71-R79 (2005). *

• Kim YG, Lee CK, Nah SS, Mun SH, Yoo B, Moon HB. Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 357: 1046-1052 (2007). *

• Kim YK, Na KS, Shin KH, Jung HY, Choi SH, Kim JB. Cytokine imbalance in the pathophysiology of major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 31: 1044-1053 (2007).

• Kim YS, Xu ZG, Reddy MA, Li SL, Lanting L, Sharma K, Adler SG, Natarajan R. Novel interactions between TGF-beta1 actions and the 12/15-lipoxygenase pathway in mesangial cells. J. Am. Soc. Nephrol. 16: 352-362 (2005). *

• Kimura A, Naka T, Kishimoto T. IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc. Natl. Acad. Sci. U.S.A. 104: 12099-12104 (2007). *

• Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J. Exp. Med. 206: 2027-2035 (2009). *

• Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc. Natl. Acad. Sci. U.S.A. 105: 9721-9726 (2008). *

• Kindlund B, Sjoling A, Hansson M, Edebo A, Hansson LE, Sjovall H, Svennerholm AM, Lundin BS. FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. Helicobacter 14: 192-201 (2009). *

• King LE, Gates RE, Stoscheck CM, Nanney LB. Epidermal growth factor/transforming growth factor alpha receptors and psoriasis. J. Invest. Dermatol. 95: 10S-12S (1990). *

• Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J. Exp. Med. 203: 1021-1031 (2006). *

• Kinnman N, Housset C. Peribiliary myofibroblasts in biliary type liver fibrosis. Front. Biosci. 7: d496-d503 (2002).

• Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol. 123: 179-186 (2009). *

• Kinoshita K, Iimuro Y, Otogawa K, Saika S, Inagaki Y, Nakajima Y, Kawada N, Fujimoto J, Friedman S, Ikeda K. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut 56: 706-714 (2007). *

• Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J. Gastroenterol. Hepatol. 22 Suppl. 1: S73-S78 (2007). *

• Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner DA. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J. Hepatol. 45: 429-438 (2006). *

• Kitani A, Xu L. Regulatory T cells and the induction of IL-17. Mucosal Immunol. 1 Suppl. 1: S43-S46 (2008).

• Kitisin K, Shetty K, Mishra L, Johnson LB. Hepatocellular stem cells. Cancer Biomark. 3: 251-262 (2007).

• Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Novak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. The nuclear receptor PPARgamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J. Exp. Med. 206: 2079-2089 (2009). *

• Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J. Exp. Med. 206: 2701-2715 (2009). *

• Kluwe J, Pradere JP, Gwak GY, Mencin A, De Minicis S, Osterreicher CH, Colmenero J, Bataller R, Schwabe RF. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 138: 347-359 (2010). *

• Kmiec Z. Cooperation of liver cells in health and disease. Adv. Anat. Embryol. Cell. Biol. 161: III-XIII, 1-151 (2001).

• Kmiec Z, Sokolowska I. Role of tumor necrosis factor family ligands in the pathogenesis of rheumatoid arthritis - new therapeutical opportunities. Pol. Merkur. Lekarski. 22: 300-304 (2007).

• Knowles MR. Gene modifiers of lung disease. Curr. Opin. Pulm. Med. 12: 416-421 (2006).

• Ko GJ, Kang YS, Han SY, Lee MH, Song HK, Han KH, Kim HK, Han JY, Cha DR. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrol. Dial. Transplant. 23: 2750-2760 (2008).

• Koca SS, Bahcecioglu IH, Poyrazoglu OK, Ozercan IH, Sahin K, Ustundag B. The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. Inflammation 31: 91-98 (2008). *

• Koca SS, Isik A, Ozercan IH, Ustundag B, Evren B, Metin K. Effectiveness of etanercept in bleomycin-induced experimental scleroderma. Rheumatology (Oxford) 47: 172-175 (2008). *

• Kochetkova I, Trunkle T, Callis G, Pascual DW. Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells. J. Immunol. 181: 2741-2752 (2008). *

• Koenen HJ, Smeets RL, Vink PM, Rijssen EV, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T-cells differentiate into IL-17 producing cells. Blood 112: 2340-2352 (2008). *

• Kofler S, Nickel T, Weis M. Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin. Sci. (Lond.) 108: 205-213 (2005). *

• Koga H, Yang H, Adler J, Zimmermann EM, Teitelbaum DH. Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment. Surgery 144: 259-268 (2008).

• Kohyama M, Hachimura S, Nanno M, Ishikawa H, Kaminogawa S. Analysis of cytokine producing activity of intestinal intraepithelial T cells from TCR beta-chain and delta-chain mutant mice. Microbiol. Immunol. 41: 353-359 (1997).

• Koivisto H, Hietala J, Niemela O. An inverse relationship between markers of fibrogenesis and collagen degradation in patients with or without alcoholic liver disease. Am. J. Gastroenterol. 102: 773-779 (2007). *

• Kojima T, Takano K, Yamamoto T, Murata M, Son S, Imamura M, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N. Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes. Liver Int. 28: 534-545 (2008). *

• Kokot A, Luger TA, Fiebich B, Bohm M. Antagonism of the serotonin pathway - a novel antifibrotic approach? Exp. Dermatol. 17: 625-626 (2008).

• Kolios G, Valatas V, Kouroumalis E. Role of Kupffer cells in the pathogenesis of liver disease. World J. Gastroenterol. 12: 7413-7420 (2006). *

• Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. U.S.A. 106: 1903-1908 (2009). *

• Kondoh K, Usui Y, Ohtani Y, Inase N, Miyake S, Yoshizawa Y. Proinflammatory and anti-inflammatory cytokine gene polymorphisms in hypersensitivity pneumonitis. J. Med. Dent. Sci. 53: 75-83 (2006).

• Kong B, Luyendyk JP, Tawfik O, Guo GL. Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J. Pharmacol. Exp. Ther. 328: 116-122 (2009). *

• Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE Jr, Sampson JH, Priebe W, Heimberger AB. A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin. Cancer Res. 14: 5759-5768 (2008). *

• Kong QF, Sun B, Bai SS, Zhai DX, Wang GY, Liu YM, Zhang SJ, Li R, Zhao W, Sun YY, Li N, Wang Q, Peng HS, Jin LH, Li HL. Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta. J. Neuroimmunol. 207: 83-91 (2009).

• Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J. TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. PLoS ONE 4: e5674 (2009). *

• Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C. Metalloproteinases and transforming growth factor-alpha mediate substance-P induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J. Biol. Chem. 279: 45519-45527 (2004). *

• Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J. Exp. Med. 203: 119-129 (2006). *

• Kopf H, de la Rosa GM, Howard OM, Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int. Immunopharmacol. 7: 1819-1824 (2007).

• Korc M, Friess H, Yamanaka Y, Kobrin MS, Buchler M, Beger HG. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Gut 35: 1468-1473 (1994). *

• Korn T, Anderson AC, Bettelli E, Oukka M. The dynamics of effector T cells and Foxp3(+) regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J. Neuroimmunol. 191: 51-60 (2007).

• Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448: 484-488 (2007). *

• Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu. Rev. Immunol. 27: 485-517 (2009). *

• Korn T, Oukka M, Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 19: 362-371 (2007). *

• Kornbluth RS, Stone GW. Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J. Leukoc. Biol. 80: 1084-1102 (2006). *

• Kosa JP, Balla B, Kiss J, Podani J, Takacs I, Lazary A, Nagy Z, Bacsi K, Karsai A, Speer G, Lakatos P. Postmenopausal expression changes of immune system-related genes in human bone tissue. J. Clin. Immunol. 29: 761-768 (2009). *

• Koshy PJ, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann. Rheum. Dis. 61: 704-713 (2002). *

• Kou T, Marusawa H, Kinoshita K, Endo Y, Okazaki IM, Ueda Y, Kodama Y, Haga H, Ikai I, Chiba T. Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis. Int. J. Cancer 120: 469-476 (2007). *

• Koutoulaki A, Langley M, Sloan AJ, Aeschlimann D, Wei XQ. TNFalpha and TGF-beta1 influence IL-18-induced IFNgamma production through regulation of IL-18 receptor and T-bet expression. Cytokine Oct 29 [Epub ahead of print] (2009).

• Kramer G, Mitteregger D, Marberger M. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur. Urol. 51: 1202-1216 (2007).

• Krasowska-Zoladek A, Banaszewska M, Kraszpulski M, Konat GW. Kinetics of inflammatory response of astrocytes induced by TLR 3 and TLR4 ligation. J. Neurosci. Res. 85: 205-212 (2007).

• Krauss-Etschmann S, Hartl D, Rzehak P, Heinrich J, Shadid R, Ramírez-Tortosa MD, Campoy C, Pardillo S, Schendel DJ, Decsi T, Demmelmair H, Koletzko BV; Nutraceuticals for Healthier Life Study Group. Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J. Allergy Clin. Immunol. 121: 464-470.e6 (2008). *

• Kremer M, Perry AW, Milton RJ, Rippe RA, Wheeler MD, Hines IN. Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis. Hepatology 47: 113-126 (2008). *

• Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6: 1219-1227 (2005). *

• Kretschmer K, Apostolou I, Jaeckel E, Khazaie K, von Boehmer H. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol. Rev. 212: 163-169 (2006). *

• Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA. Transforming growth factor-beta: recent advances on its role in immune tolerance. Curr. Rheumatol. Rep. 8: 138-144 (2006).

• Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 114: 357-359 (2009). *

• Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W. Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression. J. Immunol. 179: 1423-1426 (2007). *

• Kubo T, Ichimiya S, Tonooka A, Nagashima T, Kikuchi T, Sato N. p63 induces CD4(+) T-cell chemoattractant TARC/CCL17 in human epithelial cells. J. Interferon Cytokine Res. 28: 725-732 (2008).

• Kuczma M, Podolsky R, Garge N, Daniely D, Pacholczyk R, Ignatowicz L, Kraj P. Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset. J. Immunol. 183: 3731-3741 (2009).

• Kudo H, Yata Y, Takahara T, Kawai K, Nakayama Y, Kanayama M, Oya T, Morita S, Sasahara M, Mann DA, Sugiyama T. Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue. Liver Int. 29: 988-996 (2009). *

• Kuhad A, Chopra K. Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway. Life Sci. 84: 296-301 (2009). *

• Kuhl AA, Pawlowski NN, Grollich K, Blessenohl M, Westermann J, Zeitz M, Loddenkemper C, Hoffmann JC. Human peripheral gammadelta T cells possess regulatory potential. Immunology 128: 580-588 (2009). *

• Kullberg MC. Immunology: soothing intestinal sugars. Nature 453: 602-604 (2008). *

• Kullberg MC, Hay V, Cheever AW, Mamura M, Sher A, Letterio JJ, Shevach EM, Piccirillo CA. TGF-beta1 production by CD4(+)CD25(+) regulatory T cells is not essential for suppression of intestinal inflammation. Eur. J. Immunol. 35: 2886-2895 (2005). *

• Kullberg MC, Jankovic D, Gorelick PL, Caspar P, Letterio JJ, Cheever AW, Sher A. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196: 505-515 (2002). *

• Kumar A, Gupta V, Changotra H, Sarin BC, Sehajpal PK. Tumor necrosis factor - alpha and transforming growth factor - beta1 polymorphisms in bronchial asthma. Indian J. Med. Sci. 62: 323-330 (2008). *

• Kumar R, Goswami R, Agarwal S, Israni N, Singh SK, Rani R. Association and interaction of the TNF-alpha gene with other pro- and anti-inflammatory cytokine genes and HLA genes in patients with type 1 diabetes from North India. Tissue Antigens 69: 557-567 (2007). *

• Kuno Y, Ina K, Nishiwaki T, Tsuzuki T, Shimada M, Imada A, Nishio Y, Nobata K, Suzuki T, Ando T, Hibi K, Nakao A, Yokoyama T, Yokoyama Y, Kusugami K. Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis. J. Gastroenterol. 37 Suppl. 14: 22-32 (2002).

• Kunz D, Walker G, Bedoucha M, Certa U, Maerz-Weiss P, Dimitriades-Schmutz B, Otten U. Expression profiling and ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells. BMC Genomics 10: 90 (2009). *

• Kunz M. Current treatment of psoriasis with biologics. Curr. Drug Discov. Technol. 6: 231-240 (2009).

• Kushwah R, Oliver JR, Zhang J, Siminovitch KA, Hu J. Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells. J. Immunol. 183: 7104-7118 (2009).

• Kushwah R, Wu J, Oliver JR, Jiang G, Zhang J, Siminovitch KA, Hu J. Uptake of apoptotic DC converts immature DC into tolerogenic DC, which induce differentiation of Foxp3+ regulatory T cells. Eur. J. Immunol. Jan 25 [Epub ahead of print] (2010). *

• Kuwabara T, Ishikawa F, Yasuda T, Aritomi K, Nakano H, Tanaka Y, Okada Y, Lipp M, Kakiuchi T. CCR 7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells. J. Immunol. 183: 2513-2521 (2009).

• Kwak JH, Kim SI, Kim JK, Choi ME. BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells. J. Biol. Chem. 283: 19816-19825 (2008). *

• Kwiatkowska-Patzer B, Michalkiewicz J, Kubiszewska I, Zielinska J, Kasarello K, Kurzepa K, Lipkowski AW. Spinal cord hydrolysate ameliorate immunological reaction in experimental allergic encephalomyelitis. Acta Neurobiol. Exp. (Wars.) 69: 73-78 (2009).

• Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, Im SH. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc. Natl. Acad. Sci. U.S.A. 107: 2159-2164 (2010). *

• Kwon SJ, Lee GT, Lee JH, Kim WJ, Kim IY. Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages. Immunology 128: e758-e765 (2009).

• Kyte JA, Trachsel S, Risberg B, Thor Straten P, Lislerud K, Gaudernack G. Unconventional cytokine profiles and development of T cell memory in long-term survivors after cancer vaccination. Cancer Immunol. Immunother. 58: 1609-1626 (2009). *

• La Cava A, Fang CJ, Singh RP, Ebling F, Hahn BH. Manipulation of immune regulation in systemic lupus erythematosus. Autoimmun. Rev. 4: 515-519 (2005).

• Lafyatis R. Targeting fibrosis in systemic sclerosis. Endocr. Metab. Immune Disord. Drug Targets 6: 395-400 (2006).

• Lafyatis R, York M. Innate immunity and inflammation in systemic sclerosis. Curr. Opin. Rheumatol. 21: 617-622 (2009).

• Lagoa CE, Vodovotz Y, Stolz DB, Lhuillier F, McCloskey C, Gallo D, Yang R, Ustinova E, Fink MP, Billiar TR, Mars WM. The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Hepatology 42: 390-399 (2005). *

• Lahat N, Shapiro S, Karban A, Gerstein R, Kinarty A, Lerner A. Cytokine profile in coeliac disease. Scand. J. Immunol. 49: 441-446 (1999). *

• Lai CF, Cheng SL. Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells. J. Biol. Chem. 277: 15514-15522 (2002). *

• Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. The role of PPARs in lung fibrosis. PPAR Res. 2007: 71323 (2007). *

• Lambiase A, Micera A, Mantelli F, Moretti C, Di Zazzo A, Perrella E, Bonini S, Bonini S. T-helper 17 lymphocytes in ocular cicatricial pemphigoid. Mol. Vis. 15: 1449-1455 (2009). *

• Lamerz R. Role of tumour markers, cytogenetics. Ann. Oncol. 10 Suppl. 4: 145-149 (1999).

• Lammers KM, Vergopoulos A, Babel N, Gionchetti P, Rizzello F, Morselli C, Caramelli E, Fiorentino M, D'errico A, Volk HD, Campieri M. Probiotic therapy in the prevention of pouchitis onset: decreased interleukin-1beta, interleukin-8, and interferon-gamma gene expression. Inflamm. Bowel Dis. 11: 447-454 (2005). *

• Lampinen M, Ronnblom A, Amin K, Kristjansson G, Rorsman F, Sangfelt P, Safsten B, Wagner M, Wanders A, Winqvist O, Carlson M. Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut 54: 1714-1720 (2005). *

• Lan HY. Smad7 as a therapeutic agent for chronic kidney diseases. Front. Biosci. 13: 4984-4992 (2008).

• Lan RY, Selmi C, Gershwin ME. The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2). J. Autoimmun. 31: 7-12 (2008).

• Lang F, Gorlach A. Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448. Expert Opin. Ther. Pat. 20: 129-135 (2010).

• Langdahl BL, Carstens M, Stenkjaer L, Eriksen EF. Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis. Bone 32: 297-310 (2003). *

• Lange C, Doster H, Steinbach K, Kalbacher H, Scholl M, Melms A, Bischof F. Differential modulation of CNS-specific effector and regulatory T cells during tolerance induction by recombinant invariant chains in vivo. Brain Behav. Immun. 23: 861-867 (2009).

• Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 105: 10865-10870 (2008). *

• Larche M. Regulatory T cells in allergy and asthma. Chest 132: 1007-1014 (2007). *

• Latella G, Sferra R, Vetuschi A, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Gaudio E. Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid. Eur. J. Clin. Invest. 38: 410-420 (2008).

• Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G, Flanders KC, Gaudio E. Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int. 29: 997-1009 (2009). *

• Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Flanders KC, Gaudio E. Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis. Eur. J. Clin. Invest. 39: 145-156 (2009).

• Latinne D, Fiasse R. New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases. Acta Gastroenterol. Belg. 69: 393-405 (2006).

• Lau HH, Ng MY, Cheung WM, Paterson AD, Sham PC, Luk KD, Chan V, Kung AW. Assessment of linkage and association of 13 genetic loci with bone mineral density. J. Bone Miner. Metab. 24: 226-234 (2006). *

• Lavasani S, Dzhambazov B, Nouri M, Fak F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Westrom B. A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One 5: e9009 (2010). *

• Lavrnja I, Stojkov D, Bjelobaba I, Pekovic S, Dacic S, Nedeljkovic N, Mostarica-Stojkovic M, Stosic-Grujicic S, Rakic L, Stojiljkovic M. Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. Int. Immunopharmacol. 8: 1282-1290 (2008).

• Lawrance IC, Maxwell L, Doe W. Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflamm. Bowel Dis. 7: 226-236 (2001). *

• Lawrance IC, Maxwell L, Doe W. Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine. Inflamm. Bowel Dis. 7: 16-26 (2001). *

• Lawrance IC, Wu F, Leite AZ, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology 125: 1750-1761 (2003). *

• Layh-Schmitt G, Colbert RA. The interleukin-23/interleukin-17 axis in spondyloarthritis. Curr. Opin. Rheumatol. 20: 392-397 (2008).

• Le Gouvello S, Bastuji-Garin S, Aloulou N, Mansour H, Chaumette MT, Berrehar F, Seikour A, Charachon A, Karoui M, Leroy K, Farcet JP, Sobhani I. High prevalence of Foxp3 and IL-17 in MMR-proficient colorectal carcinomas. Gut 57: 772-779 (2008). *

• Le Pabic H, L'Helgoualc'h A, Coutant A, Wewer UM, Baffet G, Clement B, Theret N. Involvement of the serine/threonine p70(S6) kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J. Hepatol. 43: 1038-1044 (2005). *

• Leandro AC, Rocha MA, Cardoso CS, Bonecini-Almeida MG. Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-gamma genes and its association with susceptibility to tuberculosis. Braz. J. Med. Biol. Res. 42: 312-322 (2009). *

• Leask A. Scar wars: is TGFbeta the phantom menace in scleroderma? Arthritis Res. Ther. 8: 213 (2006). *

• Leask A. Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. Cell. Signal. 20: 1409-1414 (2008). *

• Lechler R, Chai JG, Marelli-Berg F, Lombardi G. T-cell anergy and peripheral T-cell tolerance. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 356: 625-637 (2001). *

• Lee CH, Kim HD, Shin SM, Kim SG. A novel mechanism of PPARgamma regulation of TGFbeta1: implication in cancer biology. PPAR Res. 2008: 762398 (2008). *

• Lee EB, Kim JY, Lee YJ, Abdallah A, Lympany P, Song YW. Transforming growth factor-beta1 polymorphisms in Korean patients with systemic sclerosis. Tissue Antigens 63: 491-495 (2004). *

• Lee HC, Vinodhkumar R, Yoon JW, Park SK, Lee CW, Kim HY. Enhanced inhibitory effect of ultra-fine granules of red ginseng on LPS-induced cytokine expression in the monocyte-derived macrophage THP-1 cells. Int. J. Mol. Sci. 9: 1379-1392 (2008). *

• Lee IY, Cho W, Kim J, Park CS, Choe J. Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases. J. Immunol. 180: 1390-1397 (2008). *

• Lee J, Ahnn J, Bae SC. Homologs of RUNX and CBF beta/PEBP2 beta in C. elegans. Oncogene 23: 4346-4352 (2004). *

• Lee JC, Krochak R, Blouin A, Kanterakis S, Chatterjee S, Arguiri E, Vachani A, Solomides CC, Cengel KA, Christofidou-Solomidou M. Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol. Ther. 8: 47-53 (2009).

• Lee JE, Lee JS, Hwang SH. Microarray for genes associated with signal transduction in diabetic OLETF keratocytes. Korean J. Ophthalmol. 21: 111-119 (2007).

• Lee KS. Hepatic fibrogenesis. Korean J. Gastroenterol. 48: 297-305 (2006).

• Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-Myb expression. J. Clin. Invest. 96: 2461-2468 (1995). *

• Lee M, Kovacs-Nolan J, Yang C, Archbold T, Fan MZ, Mine Y. Hen egg lysozyme attenuates inflammation and modulates local gene expression in a porcine model of dextran sodium sulfate (DSS)-induced colitis. J. Agric. Food Chem. 57: 2233-2240 (2009). *

• Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J. Cell. Biochem. 73: 114-125 (1999). *

• Lee MS, Kim YJ. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 76: 447-480 (2007). *

• Lee SJ, Yang EK, Kim SG. Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated S6K1 inhibition: role for Zf9 dephosphorylation. Mol. Pharmacol. 70: 415-425 (2006). *

• Lee TY, Chang HH, Chen JH, Hsueh ML, Kuo JJ. Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats. J. Ethnopharmacol. 109: 318-324 (2007). *

• Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood Nov 12 [Epub ahead of print] (2009). *

• Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental plasticity of Th17 and Treg cells. Curr. Opin. Immunol. 21: 274-280 (2009).

• Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity 30: 92-107 (2009). *

• Lefkowitch JH. Hepatobiliary pathology. Curr. Opin. Gastroenterol. 23: 221-231 (2007).

• Lehner T. Special regulatory T cell review: the resurgence of the concept of contrasuppression in immunoregulation. Immunology 123: 40-44 (2008). *

• Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Whitfield ML, Lafyatis R. Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J. Invest. Dermatol. Feb 25 [Epub ahead of print] (2010).

• Lemke LB, Ge Z, Whary MT, Feng Y, Rogers AB, Muthupalani S, Fox JG. Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology. Infect. Immun. 77: 2147-2158 (2009). *

• Leng Q, Bentwich Z, Borkow G. Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation. Int. Immunol. 18: 637-644 (2006). *

• Leon AJ, Garrote JA, Arranz E. Cytokines in the pathogeny of celiac disease. Med. Clin. (Barc.) 125: 508-516 (2005).

• Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma expressing Th17 cells drive chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136: 257-267 (2009). *

• Leung WK, Chan MC, To KF, Man EP, Ng EK, Chu ES, Lau JY, Lin SR, Sung JJ. H. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population. Am. J. Gastroenterol. 101: 714-720 (2006). *

• Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, Ayyoub M, Valmori D. Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells. J. Immunother. 32: 101-108 (2009).

• Levings MK, Sangregorio R, Roncarolo MG. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193: 1295-1302 (2001). *

• Levy C, Lindor KD. Management of primary biliary cirrhosis. Curr. Treat. Options Gastroenterol. 6: 493-498 (2003).

• Lewindon PJ, Pereira TN, Hoskins AC, Bridle KR, Williamson RM, Shepherd RW, Ramm GA. The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease. Am. J. Pathol. 160: 1705-1715 (2002). *

• Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc. Natl. Acad. Sci. U.S.A. 105: 16236-16241 (2008). *

• Lexberg MH, Taubner A, Forster A, Albrecht I, Richter A, Kamradt T, Radbruch A, Chang HD. Th memory for interleukin-17 expression is stable in vivo. Eur. J. Immunol. 38: 2654-2664 (2008). *

• Li F, Bronson S, Niyibizi C. Derivation of murine induced pluripotent stem cells (iPS) and assessment of their differentiation toward osteogenic lineage. J. Cell. Biochem. Dec 28 [Epub ahead of print] (2009).

• Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 208: 54-60 (2009).

• Li H, Yu JP, Cao S, Wei F, Zhang P, An XM, Huang ZT, Ren XB. CD(4)(+)CD(25)(+) regulatory T cells decreased the antitumor activity of cytokine-induced killer (CIK) cells of lung cancer patients. J. Clin. Immunol. 27: 317-326 (2007). *

• Li H, Zhang GX, Chen Y, Xu H, Fitzgerald DC, Zhao Z, Rostami A. CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. J. Immunol. 181: 2483-2493 (2008). *

• Li J, Kleeff J, Guweidhi A, Esposito I, Berberat PO, Giese T, Buchler MW, Friess H. RUNX3 expression in primary and metastatic pancreatic cancer. J. Clin. Pathol. 57: 294-299 (2004). *

• Li J, Lai MD, Huang Q. Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer. Zhejiang Da Xue Xue Bao Yi Xue Ban 33: 108-114 (2004).

• Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 28: 468-476 (2008). *

• Li MO, Sanjabi S, Flavell RA. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25: 455-471 (2006). *

• Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26: 579-591 (2007). *

• Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 24: 99-146 (2006). *

• Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-124 (2002). *

• Li R, Perez N, Karumuthil-Melethil S, Prabhakar BS, Holterman MJ, Vasu C. Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25 TGF-beta1+ adaptive regulatory T cells. J. Immunol. 179: 5191-5203 (2007). *

• Li RW, Gasbarre LC. A temporal shift in regulatory networks and pathways in the bovine small intestine during Cooperia oncophora infection. Int. J. Parasitol. 39: 813-824 (2009). *

• Li T, Chiang JY. A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. Gastroenterology 133: 1660-1669 (2007). *

• Li T, Ma H, Chiang JY. TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J. Lipid Res. 49: 1981-1989 (2008). *

• Li W, Carper K, Zheng XX, Kuhr CS, Reyes JD, Liang Y, Perkins DL, Thomson AW, Perkins JD. The role of Foxp3+ regulatory T cells in liver transplant tolerance. Transplant. Proc. 38: 3205-3206 (2006). *

• Li X, Ye F, Chen H, Lu W, Wan X, Xie X. Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Lett. 253: 144-153 (2007).

• Li X, Yue ZC, Zhang YY, Bai J, Meng XN, Geng JS, Fu SB. Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer. J. Clin. Lab. Anal. 22: 164-171 (2008).

• Li Y, Wen X, Spataro BC, Hu K, Dai C, Liu Y. Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. J. Am. Soc. Nephrol. 17: 54-65 (2006). *

• Li YL, Wu J, Wei D, Zhang DW, Feng H, Chen ZN, Bian H. Newcastle disease virus represses the activation of human hepatic stellate cells and reverses the development of hepatic fibrosis in mice. Liver Int. 29: 593-602 (2009). *

• Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, Montecino M, Hassan MQ, Gaur T, Lengner CJ, Young DW. Networks and hubs for the transcriptional control of osteoblastogenesis. Rev. Endocr. Metab. Disord. 7: 1-16 (2006). *

• Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203: 2271-2279 (2006). *

• Liang TJ, Yuan JH, Tan YR, Ren WH, Han GQ, Zhang J, Wang LC, Qin CY. Effect of ursodeoxycholic acid on TGF beta1/Smad signaling pathway in rat hepatic stellate cells. Chin. Med. J. (Engl.) 122: 1209-1213 (2009).

• Liangpunsakul S, Chalasani N. Treatment of nonalcoholic fatty liver disease. Curr. Treat. Options Gastroenterol. 6: 455-463 (2003).

• Liao JJ, Huang MC, Goetzl EJ. Cutting edge: alternative signaling of Th17 cell development by sphingosine 1-phosphate. J. Immunol. 178: 5425-5428 (2007). *

• Liberek A, Jakobkiewicz-Banecka J, Kloska A, Swiderska J, Marek A, Luczak G, Wierzbicki PM, Kmiec Z, Szlagatys-Sidorkiewicz A, Marek K, Sznurkowska K, Gora-Gebka M, Liberek T, Zagierski M, Kaminska B, Wegrzyn G. Gene polymorphism of transforming growth factor beta1 (TGF-beta1) in the pathogenesis and clinical course of chronic hepatitis in children. Med. Wieku. Rozwoj. XIII: 171-179 (2009).

• Libertin CR, Ling-Indeck L, Padilla M, Woloschak GE. Cytokine and T-cell subset abnormalities in immunodeficient wasted mice. Mol. Immunol. 31: 753-759 (1994).

• Liebhart J, Polak M, Dabrowski A, Dobek R, Liebhart E, Dor-Wojnarowska A, Barg W, Kulczak A, Medrala W, Gladysz U, Lange A. The G/G genotype of transforming growth factor beta 1 (TGF-beta1) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics. Int. J. Immunogenet. 35: 417-422 (2008). *

• Lim CP, Phan TT, Lim IJ, Cao X. Cytokine profiling and Stat3 phosphorylation in epithelial-mesenchymal interactions between keloid keratinocytes and fibroblasts. J. Invest. Dermatol. 129: 851-861 (2009). *

• Lim DS, Kang MS, Jeong JA, Bae YS. Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice. Eur. J. Immunol. 39: 1334-1343 (2009). *

• Limaye PB, Bowen WC, Orr AV, Luo J, Tseng GC, Michalopoulos GK. Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology 47: 1702-1713 (2008). *

• Limer KL, Tosh K, Bujac SR, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir KR, Maciewicz RA. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Osteoarthritis Cartilage 17: 782-789 (2009).

• Lin BR, Chang CC, Che TF, Chen ST, Chen RJ, Yang CY, Jeng YM, Liang JT, Lee PH, Chang KJ, Chau YP, Kuo ML. Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer. Gastroenterology 128: 9-23 (2005). *

• Lin CC, Yin MC, Liu WH. Alleviative effects of S-allyl cysteine and S-ethyl cysteine on MCD diet-induced hepatotoxicity in mice. Food Chem. Toxicol. 46: 3401-3406 (2008). *

• Lin JT, Kitzmiller TJ, Cates JM, Gorham JD. MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury. Lab. Invest. 85: 550-561 (2005). *

• Lin X, Chen Y, Meng A, Feng X. Termination of TGF-beta superfamily signaling through SMAD dephosphorylation - a functional genomic view. J. Genet. Genomics 34: 1-9 (2007).

• Link J. Interferon-gamma, interleukin-4 and transforming growth factor-beta mRNA expression in multiple sclerosis and myasthenia gravis. Acta Neurol. Scand. Suppl. 158: 1-58 (1994).

• Lires-Dean M, Carames B, Cillero-Pastor B, Galdo F, Lopez-Armada MJ, Blanco FJ. Anti-apoptotic effect of transforming growth factor-beta1 on human articular chondrocytes: role of protein phosphatase 2A. Osteoarthritis Cartilage 16: 1370-1378 (2008).

• Liu C, Wang Q, Liu F, Li H, Zhu F, Wang X, Guo C, Ma C, Zhang L. The allogeneic but not syngeneic dendritic cells effectively generated regulatory T cells from total CD4(+) population without exogenous cytokines. Scand. J. Immunol. 71: 12-19 (2010). *

• Liu H, Leung BP. CD4+CD25+ regulatory T cells in health and disease. Clin. Exp. Pharmacol. Physiol. 33: 519-524 (2006). *

• Liu J, Lin F, Strainic MG, An F, Miller RH, Altuntas CZ, Heeger PS, Tuohy VK, Medof ME. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J. Immunol. 180: 5882-5889 (2008). *

• Liu L, Xu Y, Wang J, Li H. Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU). Mol. Vis. 15: 2938-2944 (2009). *

• Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J. Leukoc. Biol. 82: 354-360 (2007). *

• Liu SP, Dong WG, Wu DF, Luo HS, Yu JP. Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats. World J. Gastroenterol. 9: 2786-2790 (2003). *

• Liu VC, Wong LY, Jang T, Shah AH, Park I, Yang X, Zhang Q, Lonning S, Teicher BA, Lee C. Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta. J. Immunol. 178: 2883-2892 (2007). *

• Liu W, Levi G, Shanske A, Frenz DA. Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling. Birth Defects Res. B. Dev. Reprod. Toxicol. 83: 134-144 (2008).

• Liu X. Inflammatory cytokines augments TGF-beta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I. Cell Motil. Cytoskeleton 65: 935-944 (2008).

• Liu X, Kelm RJ Jr, Strauch AR. TGFbeta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by TNFalpha via MEK1-dependent induction of the Egr-1 transcriptional repressor. Mol. Biol. Cell 20: 2174-2185 (2009). *

• Liu X, Lu L, Tao BB, Zhu YC. All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta1 and Ang II in rat mesangial cells. Acta Pharmacol. Sin. 29: 1035-1041 (2008).

• Liu X, Zhang Y, Yu Y, Yang X, Cao X. SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling. Mol. Immunol. 45: 1405-1413 (2008). *

• Liu XJ, Zhang JF, Sun B, Peng HS, Kong QF, Bai SS, Liu YM, Wang GY, Wang JH, Li HL. Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6. Clin. Exp. Immunol. 158: 37-44 (2009). *

• Liu Y, Teige I, Birnir B, Issazadeh-Navikas S. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 12: 518-525 (2006). *

• Liu Y, Teige I, Ericsson I, Navikas V, Issazadeh-Navikas S. Suppression of EAE by oral tolerance is independent of endogenous IFN-beta whereas treatment with recombinant IFN-beta ameliorates EAE. Immunol. Cell Biol. Jan 12 [Epub ahead of print] (2010). *

• Liu Y, van Goor H, Havinga R, Baller JF, Bloks VW, van der Leij FR, Sauer PJ, Kuipers F, Navis G, de Borst MH. Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response. Am. J. Physiol. Renal Physiol. 294: F768-F776 (2008). *

• Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W. A critical function for TGF-beta signaling in the development of natural CD4(+)CD25(+)Foxp3(+) regulatory T cells. Nat. Immunol. 9: 632-640 (2008). *

• Llopis M, Antolin M, Carol M, Borruel N, Casellas F, Martinez C, Espin-Basany E, Guarner F, Malagelada JR. Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa. Inflamm. Bowel Dis. 15: 275-283 (2009). *

• Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity 31: 438-449 (2009). *

• Lluis JM, Nachbur U, Cook WD, Gentle IE, Moujalled D, Moulin M, Wong WW, Khan N, Chau D, Callus BA, Vince JE, Silke J, Vaux DL. TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. PLoS One 5: e8620 (2010). *

• Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, Riethmacher D, Si-Tahar M, Di Santo JP, Eberl G. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J. Exp. Med. 205: 1381-1393 (2008). *

• Locke NR, Patterson SJ, Hamilton MJ, Sly LM, Krystal G, Levings MK. SHIP regulates the reciprocal development of T regulatory and Th17 cells. J. Immunol. 183: 975-983 (2009).

• Lohmann CH, Schwartz Z, Liu Y, Li Z, Simon BJ, Sylvia VL, Dean DD, Bonewald LF, Donahue HJ, Boyan BD. Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells. J. Orthop. Res. 21: 326-334 (2003). *

• Lohr J, Knoechel B, Abbas AK. Regulatory T cells in the periphery. Immunol. Rev. 212: 149-162 (2006). *

• Long C, Yin B, Lu Q, Zhou X, Hu J, Yang Y, Yu F, Yuan Y. Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma. Cancer Invest. 25: 685-690 (2007).

• Longhi MS, Hussain MJ, Mitry RR, Arora SK, Mieli-Vergani G, Vergani D, Ma Y. Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis. J. Immunol. 176: 4484-4491 (2006). *

• Loser K, Beissert S. Dendritic cells and T cells in the regulation of cutaneous immunity. Adv. Dermatol. 23: 307-333 (2007).

• Lotz M, Konig T, Menard S, Gutle D, Bogdan C, Hornef MW. Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells. Immunology 122: 306-315 (2007). *

• Loughlin J. Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr. Opin. Rheumatol. 17: 629-633 (2005).

• Loures FV, Pina A, Felonato M, Calich VL. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J. Immunol. 183: 1279-1290 (2009).

• Lowder T, Dugger K, Deshane J, Estell K, Schwiebert LM. Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model. Brain Behav. Immun. 24: 153-159 (2010).

• Lowe EL, Doherty TM, Karahashi H, Arditi M. Ubiquitination and de-ubiquitination: role in regulation of signaling by Toll-like receptors. J. Endotoxin Res. 12: 337-345 (2006). *

• Lu LY, Cheng HH, Sung PK, Tai MH, Yeh JJ, Chen A. Tumor necrosis factor-beta +252a polymorphism is associated with systemic lupus erythematosus in Taiwan. J. Formos. Med. Assoc. 104: 563-570 (2005).

• Lu LY, Cheng HH, Sung PK, Yeh JJ, Shiue YL, Chen A. Single-nucleotide polymorphisms of transforming growth factor-beta1 gene in Taiwanese patients with systemic lupus erythematosus. J. Microbiol. Immunol. Infect. 37: 145-152 (2004). *

• Lu LY, Chu JJ, Lu PJ, Sung PK, Hsu CM, Tseng JC. Expression of intracellular transforming growth factor-beta1 in CD4(+)CD25(+) cells in patients with systemic lupus erythematosus. J. Microbiol. Immunol. Infect. 41: 165-173 (2008). *

• Lu T, Tian L, Han Y, Vogelbaum M, Stark GR. Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 104: 4365-4370 (2007). *

• Luangsay S, Kasper LH, Rachinel N, Minns LA, Mennechet FJ, Vandewalle A, Buzoni-Gatel D. CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells. Gastroenterology 125: 491-500 (2003). *

• Luczynski W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A, Urban R, Ilendo E, Urban M, Hryszko M, Kretowski A, Gorska M. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. Acta Biochim. Pol. 56: 361-370 (2009). *

• Luedde T, Trautwein C. A molecular link between inflammation and fibrogenesis: the bacterial microflora influences hepatic fibrosis via Toll-like receptor 4-dependent modification of transforming growth factor-beta signaling in hepatic stellate cells. Hepatology 47: 1089-1091 (2008). *

• Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T. Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J. Clin. Invest. 117: 3306-3315 (2007). *

• Luo JH, Ren B, Keryanov S, Tseng GC, Rao UN, Monga SP, Strom S, Demetris AJ, Nalesnik M, Yu YP, Ranganathan S, Michalopoulos GK. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 44: 1012-1024 (2006). *

• Luo X, Tarbell KV, Yang H, Pothoven K, Bailey SL, Ding R, Steinman RM, Suthanthiran M. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 104: 2821-2826 (2007). *

• Luth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Bruck W, Wraith DC, Herkel J, Lohse AW. Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J. Clin. Invest. 118: 3403-3410 (2008). *

• Lv J, Liu Q, Hua L, Dong X, Bao Y. Association of five single nucleotide polymorphism loci with asthma in children of Chinese Han nationality. J. Asthma 46: 582-585 (2009).

• Lv P, Luo HS, Zhou XP, Chireyath Paul S, Xiao YJ, Si XM, Liu SQ. Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress. Pathol. Res. Pract. 202: 777-788 (2006).

• Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F. Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol. Rev. 226: 112-131 (2008). *

• Lyakhovich A, Gasche C. Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine. Aliment. Pharmacol. Ther. 31: 202-209 (2010). *

• Lykouras D, Sampsonas F, Kaparianos A, Karkoulias K, Tsoukalas G, Spiropoulos K. Human genes in TB infection: their role in immune response. Monaldi Arch. Chest Dis. 69: 24-31 (2008).

• Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J. Clin. Invest. 116: 1274-1283 (2006). *

• Ma D, Zhu X, Zhao P, Zhao C, Li X, Zhu Y, Li L, Sun J, Peng J, Ji C, Hou M. Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann. Hematol. 87: 899-904 (2008). *

• Ma Y, Guan Q, Bai A, Weiss CR, Hillman CL, Ma A, Zhou G, Qing G, Peng Z. Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflamm. Bowel Dis. Nov 18 [Epub ahead of print] (2009). *

• Ma Y, Ren S, Pandak WM, Li X, Ning Y, Lu C, Zhao F, Yin L. The effects of inflammatory cytokines on steroidogenic acute regulatory protein expression in macrophages. Inflamm. Res. 56: 495-501 (2007). *

• Mabalirajan U, Dinda AK, Sharma SK, Ghosh B. Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model. J. Immunol. 183: 2059-2067 (2009).

• Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol. Biomarkers Prev. 14: 1613-1618 (2005). *

• MacDermott RP. Alterations of the mucosal immune system in inflammatory bowel disease. J. Gastroenterol. 31: 907-916 (1996).

• MacDonald TT. Effector and regulatory lymphoid cells and cytokines in mucosal sites. Curr. Top. Microbiol. Immunol. 236: 113-135 (1999).

• MacDonald TT. The cytokine network in IBD. Falk Symposium 154: INFLAMMATORY BOWEL DISEASE - DIAGNOSTIC AND THERAPEUTIC STRATEGIES, Moscow (Russia), June 9 - 10, 2006, p. 24 (2006). *

• MacDonald TT, Disabatino A, Gordon JN. Immunopathogenesis of Crohn's disease. JPEN J. Parenter. Enteral Nutr. 29: S118-S125 (2005). *

• Mackay IR. Foreword. Contemporary liver immunology and immunopathology: obstacles and opportunities. In "Liver Immunology: Principles and Practice" (eds. Gershwin ME, Vierling JM, Manns MP), Humana Press Inc., Totowa, NJ, p. 1-14 (2007). *

• Macpherson AJ, Slack E. The functional interactions of commensal bacteria with intestinal secretory IgA. Curr. Opin. Gastroenterol. 23: 673-678 (2007). *

• Madala SK, Pesce JT, Ramalingam TR, Wilson MS, Minnicozzi S, Cheever AW, Thompson RW, Mentink-Kane MM, Wynn TA. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J. Immunol. Feb 24 [Epub ahead of print] (2010).

• Magen E, Feldman A, Cohen Z, Alon DB, Minz E, Chernyavsky A, Linov L, Mishal J, Schlezinger M, Sthoeger Z. Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension. Am. J. Med. Sci. 339: 117-122 (2010).

• Maggi E, Cosmi L, Liotta F, Romagnani P, Romagnani S, Annunziato F. Thymic regulatory T cells. Autoimmun. Rev. 4: 579-586 (2005).

• Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamons A, Drivdahl R, Zeng W, Lai L, Huycke M, Phelps S, Brabb T, Iritani BM. Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. Am. J. Pathol. 174: 317-329 (2009). *

• Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H, Iritani BM. Helicobacter infection is required for inflammation and colon cancer in smad3-deficient mice. Cancer Res. 66: 828-838 (2006). *

• Magro CM, Dyrsen M, Kerns MJ. Cutaneous lesions of dermatomyositis with supervening fibrosis. J. Cutan. Pathol. 35: 31-39 (2008). *

• Mahendra A, Misra R, Aggarwal A. Th1 and Th17 predominance in the enthesitis-related srthritis form of juvenile idiopathic arthritis. J. Rheumatol. 36: 1730-1736 (2009).

• Maitra U, Davis S, Reilly CM, Li L. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J. Immunol. 182: 5763-5769 (2009).

• Makar TK, Trisler D, Bever CT, Goolsby JE, Sura KT, Balasubramanian S, Sultana S, Patel N, Ford D, Singh IS, Gupta A, Valenzuela RM, Dhib-Jalbut S. Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 196: 67-81 (2008).

• Makino H, Shimizu H, Ito H, Kimura F, Ambiru S, Togawa A, Ohtsuka M, Yoshidome H, Kato A, Yoshitomi H, Sawada S, Miyazaki M. Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy. World J. Gastroenterol. 12: 2053-2059 (2006). *

• Makwana M, Jones LL, Cuthill D, Heuer H, Bohatschek M, Hristova M, Friedrichsen S, Ormsby I, Bueringer D, Koppius A, Bauer K, Doetschman T, Raivich G. Endogenous transforming growth factor beta1 suppresses inflammation and promotes survival in adult CNS. J. Neurosci. 27: 11201-11213 (2007).

• Malemud CJ. Cytokines as therapeutic targets for osteoarthritis. BioDrugs 18: 23-35 (2004).

• Malemud CJ. Anticytokine therapy for osteoarthritis: evidence to date. Drugs Aging 27: 95-115 (2010).

• Malik M, Webb J, Catherino WH. Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells. Clin. Endocrinol. (Oxf.) 69: 462-470 (2008). *

• Malleo G, Mazzon E, Genovese T, Paola RD, Muia C, Caminiti R, Esposito E, Bella PD, Cuzzocrea S. Etanercept reduces acute tissue injury and mortality associated to zymosan-induced multiple organ dysfunction syndrome. Shock 29: 560-571 (2008). *

• Mamata Y, Hakki A, Yamamoto Y, Newton C, Klein TW, Pross S, Friedman H. Nicotine modulates cytokine production by Chlamydia pneumoniae infected human peripheral blood cells. Int. Immunopharmacol. 5: 749-756 (2005).

• Mamessier E, Botturi K, Vervloet D, Magnan A. T regulatory lymphocytes, atopy and asthma: a new concept in three dimensions. Rev. Mal. Respir. 22: 305-311 (2005).

• Manchanda PK, Kumar A, Sharma RK, Goel H, Mittal RD. Association of pro/anti-inflammatory cytokine gene variants in renal transplant patients with allograft outcome and cyclosporine immunosuppressant levels. Biologics 2: 875-884 (2008). *

• Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9: 641-649 (2008). *

• Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441: 231-234 (2006). *

• Manukyan GP, Ghazaryan KA, Ktsoyan ZA, Tatyan MV, Khachatryan ZA, Hakobyan GS, Mkrtchyan VA, Kelly D, Coutts A, Aminov RI. Cytokine profile of Armenian patients with familial Mediterranean fever. Clin. Biochem. 41: 920-922 (2008). *

• Marangoni F, Trifari S, Scaramuzza S, Panaroni C, Martino S, Notarangelo LD, Baz Z, Metin A, Cattaneo F, Villa A, Aiuti A, Battaglia M, Roncarolo MG, Dupre L. WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells. J. Exp. Med. 204: 369-380 (2007). *

• Marazuela M, Garcia-Lopez MA, Figueroa-Vega N, de la Fuente H, Alvarado-Sanchez B, Monsivais-Urenda A, Sanchez-Madrid F, Gonzalez-Amaro R. Regulatory T cells in human autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 91: 3639-3646 (2006). *

• Marchildon F, St-Louis C, Akter R, Roodman V, Wiper-Bergeron NL. Transcription factor SMAD3 is required for the inhibition of adipogenesis by retinoic acid. J. Biol. Chem. Feb 23 [Epub ahead of print] (2010). *

• Margalit M, Israeli E, Shibolet O, Zigmond E, Klein A, Hemed N, Donegan JJ, Rabbani E, Goldin, E, Ilan Y. A double-blind clinical trial for treatment of Crohn's disease by oral administration of Alequel™, a mixture of autologous colon-extracted proteins: a patient-tailored approach. Am. J. Gastroenterol. 101: 561-568 (2006). *

• Marguti I, Yamamoto GL, da Costa TB, Rizzo LV, de Moraes LV. Expansion of CD4+ CD25+ Foxp3+ T cells by bone marrow-derived dendritic cells. Immunology 127: 50-61 (2009). *

• Marinic I, Gagro A, Rabatic S. Regulatory T cells. Acta Med. Croatica 60: 447-456 (2006).

• Marinova-Mutafchieva L, Gabay C, Funa K, Williams RO. Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint. Clin. Exp. Immunol. 146: 287-293 (2006). *

• Markovic M, Miljkovic D, Momcilovic M, Popadic D, Miljkovic Z, Savic E, Ramic Z, Mostarica Stojkovic M. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Mol. Immunol. 47: 141-146 (2009). *

• Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat. Immunol. 10: 1125-1132 (2009). *

• Marks MA, Gravitt PE, Burk RR, Studentsov Y, Farzadegan H, Klein SL. Progesterone and 17beta-estradiol enhance regulatory responses to HPV 16 VLP in peripheral blood mononuclear cells from healthy women. Clin. Vaccine Immunol. Feb 3 [Epub ahead of print] (2010). *

• Marrache F, Tu SP, Bhagat G, Pendyala S, Osterreicher CH, Gordon S, Ramanathan V, Penz-Osterreicher M, Betz KS, Song Z, Wang TC. Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology 135: 1277-1287 (2008). *

• Marshall NB, Vorachek WR, Steppan LB, Mourich DV, Kerkvliet NI. Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 181: 2382-2391 (2008). *

• Marsland BJ, Nembrini C, Grun K, Reissmann R, Kurrer M, Leipner C, Kopf M. TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-{theta} signaling and promote autoimmune myocarditis. J. Immunol. 178: 3466-3473 (2007). *

• Martinez GJ, Zhang Z, Chung Y, Reynolds JM, Lin X, Jetten AM, Feng XH, Dong C. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J. Biol. Chem. 284: 35283-35286 (2009). *

• Martinez OM, Villanueva JC, Gershwin ME, Krams SM. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 21: 113-119 (1995).

• Martinez-Rizo A, Bueno-Topete M, Gonzalez-Cuevas J, Armendariz-Borunda J. Plasmin plays a key role in the regulation of profibrogenic molecules in hepatic stellate cells. Liver Int. 30: 298-310 (2010). *

• Mas E, Danjoux M, Garcia V, Carpentier S, Segui B, Levade T. IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One 4: e7929 (2009). *

• Masli S, Turpie B. Anti-inflammatory effects of tumour necrosis factor (TNF)-alpha are mediated via TNF-R2 (p75) in tolerogenic transforming growth factor-beta-treated antigen-presenting cells. Immunology 127: 62-72 (2009). *

• Mason CM, Porretta E, Zhang P, Nelson S. CD4(+) CD25(+) transforming growth factor-beta-producing T cells are present in the lung in murine tuberculosis and may regulate the host inflammatory response. Clin. Exp. Immunol. 148: 537-545 (2007). *

• Massacand JC, Kaiser P, Ernst B, Tardivel A, Burki K, Schneider P, Harris NL. Intestinal bacteria condition dendritic cells to promote IgA production. PLoS ONE 3: e2588 (2008). *

• Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J. Immunol. 178: 4901-4907 (2007). *

• Matos-Souza JR, Pithon KR, Ozahata TM, Oliveira RT, Téo FH, Blotta MH, Cliquet A Jr, Nadruz W Jr. Subclinical atherosclerosis is related to injury level but not to inflammatory parameters in spinal cord injury subjects. Spinal Cord. Feb 16 [Epub ahead of print] (2010).

• Matsubar Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Delineation of immunoregulatory properties of adult T-cell leukemia cells. Int. J. Hematol. 84: 63-69 (2006).

• Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N. Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation. J. Hepatol. 40: 917-925 (2004). *

• Matsumoto S, Nagaoka M, Hara T, Kimura-Takagi I, Mistuyama K, Ueyama S. Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells. Clin. Exp. Immunol. 136: 432-439 (2004). *

• Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, Yoshimura A. Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J. Immunol. 179: 2170-2179 (2007). *

• Matsunaga K. The utility of exhaled breath condensate analysis for asthma management. Rinsho Byori 55: 375-380 (2007).

• Matsunaga K, Ichikawa T, Yanagisawa S, Akamatsu K, Koarai A, Hirano T, Sugiura H, Minakata Y, Ichinose M. Clinical application of exhaled breath condensate analysis in asthma: prediction of FEV(1) improvement by steroid therapy. Respiration 78: 393-398 (2009).

• Matsushita T, Hasegawa M, Hamaguchi Y, Takehara K, Sato S. Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis. J. Rheumatol. 33: 275-284 (2006).

• Matsuura M, Okazaki K, Nishio A, Nakase H, Tamaki H, Uchida K, Nishi T, Asada M, Kawasaki K, Fukui T, Yoshizawa H, Ohashi S, Inoue S, Kawanami C, Hiai H, Tabata Y, Chiba T. Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis. Gastroenterology 128: 975-986 (2005). *

• Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M, Fujisawa J, Okazaki K, Seki T. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology 46: 48-57 (2007). *

• Matta B, Jha P, Bora PS, Bora NS. Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells. Am. J. Pathol. 173: 1440-1454 (2008). *

• Matta B, Jha P, Bora PS, Bora NS. Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4(+)CD25(+) T-regulatory cells. Immunol. Cell Biol. Nov 3 [Epub ahead of print] (2009). *

• Mattey DL, Kerr JR, Nixon NB, Dawes PT. Association of polymorphism in the transforming growth factor beta1 gene with disease outcome and mortality in rheumatoid arthritis. Ann. Rheum. Dis. 64: 1190-1194 (2005). *

• Mauri C, Ehrenstein MR. The 'short' history of regulatory B cells. Trends Immunol. 29: 34-40 (2008). *

• Maxmen A. Revising the Th17 recipe. J. Exp. Med. 206: 2304 (2009).

• Mayer AK, Bartz H, Fey F, Schmidt LM, Dalpke AH. Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment. Eur. J. Immunol. 38: 1689-1699 (2008). *

• Mayer AM, Guzman M, Peksa R, Hall M, Fay MJ, Jacobson PB, Romanic AM, Gunasekera SP. Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis. Mar. Drugs 5: 113-135 (2007).

• Mayer L. Review article: local and systemic regulation of mucosal immunity. Aliment. Pharmacol. Ther. 11 Suppl. 3: 81-85 (1997).

• Maynard CL, Hatton RD, Helms WS, Oliver JR, Stephensen CB, Weaver CT. Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and IL10 genes in developing regulatory T cells. J. Exp. Med. 206: 343-357 (2009). *

• Mayoral R, Valverde AM, Llorente Izquierdo C, Gonzalez-Rodríguez A, Bosca L, Martin-Sanz P. Impairment of TGF-beta signaling in caveolin-1 deficient hepatocytes: role in liver regeneration. J. Biol. Chem. Dec 5 [Epub ahead of print] (2009). *

• Mazzocca A, Fransvea E, Dituri F, Lupo L, Antonaci S, Giannelli G. Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma. Hepatology 51: 523-534 (2010).

• Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G. Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology 50: 1140-1151 (2009).

• McCarthy TL, Centrella M. Novel links among Wnt and TGF-beta signaling and Runx2. Mol. Endocrinol. Jan 21 [Epub ahead of print] (2010). *

• McClain CJ, Song Z, Barve SS, Hill DB, Deaciuc I. Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G497-G502 (2004). *

• McCole DF, Rogler G, Varki N, Barrett KE. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology 129: 591-608 (2005). *

• McDole J, Suidan G, Boespflug E, Cheng J, Chen Y, Pirko I, Johnson A. A translatable molecular approach to determining CD8 T-cell epitopes in TMEV infection. Hum. Immunol. 69: 805-810 (2008).

• McFadden JP, Baker BS, Powles AV, Fry L. Psoriasis and streptococci: the natural selection of psoriasis revisited. Br. J. Dermatol. 160: 929-937 (2009). *

• McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8: 1390-1397 (2007). *

• McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin. Immunol. 19: 372-376 (2007). *

• McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity 28: 445-453 (2008). *

• McGee HS, Stallworth AL, Agrawal T, Shao Z, Lorence L, Agrawal DK. Flt3-ligand decreases Th17 cells and SOCS proteins in the lung of house dust mite-sensitized and challenged mice. Am. J. Respir. Cell. Mol. Biol. Nov 20 [Epub ahead of print] (2009). *

• McGovern D, Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut 56: 1333-1336 (2007). *

• Mchenga SS, Wang D, Li C, Shan F, Lu C. Inhibitory effect of recombinant IL-25 on the development of dextran sulfate sodium-induced experimental colitis in mice. Cell. Mol. Immunol. 5: 425-431 (2008). *

• McHugh RS. Autoimmune gastritis is a well-defined autoimmune disease model for the study of CD4+CD25+ T cell-mediated suppression. Curr. Top. Microbiol. Immunol. 293: 153-177 (2005).

• Mega J, Fujihashi K, Kiyono H. Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. Reg. Immunol. 4: 70-78 (1992).

• Meijssen MA, Brandwein SL, Reinecker HC, Bhan AK, Podolsky DK. Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice. Am. J. Physiol. 274: G472-G479 (1998). *

• Melgar S, Yeung MM, Bas A, Forsberg G, Suhr O, Oberg A, Hammarstrom S, Danielsson A, Hammarstrom ML. Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. Clin. Exp. Immunol. 134: 127-137 (2003). *

• Mello LM, Bechara MI, Sole D, Rodrigues V Jr. TH1/TH2 balance in concomitant immediate and delayed-type hypersensitivity diseases. Immunol. Lett. 124: 88-94 (2009).

• Menager-Marcq I, Pomie C, Romagnoli P, van Meerwijk JP. CD8(+)CD28(-) regulatory T-lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology 131: 1775-1785 (2006). *

• Menard O, Butel MJ, Gaboriau-Routhiau V, Waligora-Dupriet AJ. Gnotobiotic mouse immune response induced by Bifidobacterium sp. strains isolated from infants. Appl. Environ. Microbiol. 74: 660-666 (2008).

• Menegatti E, Davit A, Francica S, Berardi D, Rossi D, Baldovino S, Tovo PA, Sena LM, Roccatello D. Genetic factors associated with rheumatoid arthritis and systemic vasculitis: evaluation of a panel of polymorphisms. Dis. Markers 27: 217-223 (2009).

• Menger MD, Vollmar B. Surgical trauma: hyperinflammation versus immunosuppression? Langenbecks Arch. Surg. 389: 475-484 (2004). *

• Mercer F, Kozhaya L, Unutmaz D. Expression and function of TNF and IL-1 receptors on human regulatory T cells. PLoS One 5: e8639 (2010). *

• Merlo CA, Boyle MP. Modifier genes in cystic fibrosis lung disease. J. Lab. Clin. Med. 141: 237-241 (2003). *

• Mesa MC, Gutierrez L, Duarte-Rey C, Angel J, Franco MA. A TGF-beta mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children. Virology Jan 21 [Epub ahead of print] (2010). *

• Mesturini R, Nicola S, Chiocchetti A, Bernardone IS, Castelli L, Bensi T, Ferretti M, Comi C, Dong C, Rojo JM, Yagi J, Dianzani U. ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naive CD4+ T cells. Eur. J. Immunol. 36: 2601-2612 (2006). *

• Metenou S, Dembele B, Konate S, Dolo H, Coulibaly SY, Coulibaly YI, Diallo AA, Soumaoro L, Coulibaly ME, Sanogo D, Doumbia SS, Wagner M, Traore SF, Klion A, Mahanty S, Nutman TB. Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population. J. Immunol. 183: 916-924 (2009).

• Metwali A, Setiawan T, Blum AM, Urban J, Elliott DE, Hang L, Weinstock JV. Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G253-G259 (2006). *

• Meunier L, Bohjanen K, Voorhees JJ, Cooper KD. Retinoic acid upregulates human Langerhans cell antigen presentation and surface expression of HLA-DR and CD11c, a beta 2 integrin critically involved in T-cell activation. J. Invest. Dermatol. 103: 775-779 (1994). *

• Meurens F, Berri M, Siggers RH, Willing BP, Salmon H, Van Kessel AG, Gerdts V. Commensal bacteria and expression of two major intestinal chemokines, TECK/CCL25 and MEC/CCL28, and their receptors. PLoS ONE 2: e677 (2007). *

• Meyer A, Dork T, Bogdanova N, Brinkhaus MJ, Wiese B, Hagemann J, Serth J, Bremer M, Baumann R, Karstens JH, Machtens S. TGFB1 gene polymorphism Leu10Pro (c.29T>C), prostate cancer incidence and quality of life in patients treated with brachytherapy. World J. Urol. 27: 371-377 (2009). *

• Mi Q, Riviere B, Clermont G, Steed DL, Vodovotz Y. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen. 15: 671-682 (2007). *

• Miao F, Smith DD, Zhang L, Min A, Feng W, Natarajan R. Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes. Diabetes 57: 3189-3198 (2008). *

• Michaelis K, Wallbrecht K, Kerstan A, Beyersdorf N, Williams C, Kerkau T, Wang XJ, Hunig T, Schon MP. Modulating T cell functions does not alleviate chronic inflammatory skin lesions in K5.TGFbeta1 transgenic mice. Exp. Dermatol. Jan 19 [Epub ahead of print] (2010).

• Michel K, Roth S, Trautwein C, Gong W, Flemming P, Gressner AM. Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region. Hepatology 27: 1592-1599 (1998). *

• Mieliauskaite D, Venalis P, Dumalakiene I, Venalis A, Distler J. Relationship between serum levels of TGF-beta1 and clinical parameters in patients with rheumatoid arthritis and Sjogren's syndrome secondary to rheumatoid arthritis. Autoimmunity 42: 356-358 (2009).

• Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD. TGF-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual-mechanism involving functional cooperation with NF-kbeta and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK. J. Biol. Chem. 281: 22397-22408 (2006). *

• Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield ML, Gorham JD. The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis. Liver Int. 29: 1307-1315 (2009). *

• Miller SD, McMahon EJ, Schreiner B, Bailey SL. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 1103: 179-191 (2007). *

• Mills KH. Induction, function and regulation of IL-17-producing T cells. Eur. J. Immunol. 38: 2636-2649 (2008). *

• Min KM, Kim PH. Macrophage-derived TGF-beta1 induces IgA isotype expression. Mol. Cells 16: 245-250 (2003). *

• Minns LA, Buzoni-Gatel D, Ely KH, Rachinel N, Luangsay S, Kasper LH. A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis. Gastroenterology 127: 119-126 (2004). *

• Minuk GY. Hepatic regeneration: if it ain't broke, don't fix it. Can. J. Gastroenterol. 17: 418-424 (2003). *

• Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361: 888-898 (2009). *

• Mirshafiey A, Mohsenzadegan M. TGF-beta as promising option in treatment of multiple sclerosis. Neuropharmacology 56: 929-936 (2009).

• Mishra B, Tang Y, Katuri V, Fleury T, Said AH, Rashid A, Jogunoori W, Mishra L. Loss of cooperative function of transforming growth factor-signaling proteins, smad3 with embryonic liver fodrin, a-spectrin, in primary biliary cirrhosis. Liver Int. 24: 637-645 (2004). *

• Mishra L, Banker T, Murray J, Byers S, Thenappan A, He AR, Shetty K, Johnson L, Reddy EP. Liver stem cells and hepatocellular carcinoma. Hepatology 49: 318-329 (2009). *

• Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 310: 68-71 (2005). *

• Mitchell P, Afzali B, Lombardi G, Lechler RI. The T helper 17-regulatory T cell axis in transplant rejection and tolerance. Curr. Opin. Organ Transplant. 14: 326-331 (2009).

• Mittal R, Bulgheresi S, Emami C, Prasadarao NV. Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs. J. Immunol. 183: 6588-6599 (2009).

• Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. Rheumatology (Oxford) 47: 158-164 (2008). *

• Miyahara Y, Odunsi K, Chen W, Peng G, Matsuzaki J, Wang RF. Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc. Natl. Acad. Sci. U.S.A. 105: 15505-15510 (2008). *

• Miyazono K, Maeda S, Imamura T. Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. Oncogene 23: 4232-4237 (2004). *

• Miyazono K, Suzuki H, Imamura T. Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci. 94: 230-234 (2003). *

• Mizoguchi A, Bhan AK. A case for regulatory B cells. J. Immunol. 176: 705-710 (2006). *

• Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Kanda T, Yoshida H, Takizawa T, Tajiri T. Short hairpin RNA modulates transforming growth factor beta signaling in life-threatening liver failure in mice. Gastroenterology 129: 1654-1662 (2005). *

• Mizuno M, Blanchin S, Gasque P, Nishikawa K, Matsuo S. High levels of complement C3a receptor in the glomeruli in lupus nephritis. Am. J. Kidney Dis. 49: 598-606 (2007).

• Mochizuki M. Regional immunity of the eye. Acta Ophthalmol. Nov 7 [Epub ahead of print] (2009).

• Moehle C, Ackermann N, Langmann T, Aslanidis C, Kel A, Kel-Margoulis O, Schmitz-Madry A, Zahn A, Stremmel W, Schmitz G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Mol. Med. 84: 1055-1066 (2006). *

• Moles A, Tarrats N, Fernandez-Checa JC, Mari M. Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology 49: 1297-1307 (2009). *

• Monari C, Bevilacqua S, Piccioni M, Pericolini E, Perito S, Calvitti M, Bistoni F, Kozel TR, Vecchiarelli A. A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production. J. Immunol. 183: 191-200 (2009).

• Mondello S, Mazzon E, Di Paola R, Crisafulli C, Mondello P, Buemi M, Aloisi C, Cuzzocrea S. Thalidomide suppresses sclerosing encapsulating peritonitis in a rat experimental model. Shock 32: 332-339 (2009).

• Mondello S, Mazzon E, Paola RD, Crisafulli C, Mondello P, Buemi M, Aloisi C, Cuzzocrea S. Thalidomide suppresses sclerosing encapsulating peritonitis in rats experimental model. Shock Dec 22 [Epub ahead of print] (2008).

• Montagnoli C, Bozza S, Gaziano R, Zelante T, Bonifazi P, Moretti S, Bellocchio S, Pitzurra L, Romani L. Immunity and tolerance to Aspergillus fumigatus. Novartis Found. Symp. 279: 66-77 (2006).

• Montagnoli C, Fallarino F, Gaziano R, Bozza S, Bellocchio S, Zelante T, Kurup WP, Pitzurra L, Puccetti P, Romani L. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J. Immunol. 176: 1712-1723 (2006). *

• Montalvao F, Almeida GM, Silva EM, Borges VM, Vasconcellos R, Takiya CM, Lopes MF, Nunes MP, Dosreis GA. Apoptotic lymphocytes treated with IgG from Trypanosoma cruzi infection increase TNF-alpha secretion and reduce parasite replication in macrophages. Eur. J. Immunol. Nov 30 [Epub ahead of print] (2009). *

• Monteleone G, Boirivant M, Pallone F, MacDonald TT. TGF-beta1 and Smad7 in the regulation of IBD. Mucosal Immunol. 1 Suppl. 1: S50-S53 (2008).

• Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G, Bernardini S, Pallone F, Macdonald TT. Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Gastroenterology 129: 1420-1429 (2005). *

• Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J. Clin. Invest. 108: 601-609 (2001). *

• Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R, Alessandroni L, Mann D, Pallone F, MacDonald TT. A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J. Biol. Chem. 279: 3925-3932 (2004). *

• Monteleone G, Pallone F, Macdonald TT. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol. 29: 290-294 (2008). *

• Moore B, Murphy RF, Agrawal DK. Interaction of TGF-beta with immune cells in airway disease. Curr. Mol. Med. 8: 427-436 (2008).

• Moore C, Sauma D, Morales J, Bono MR, Rosemblatt M, Fierro JA. Transforming browth factor-beta and all-trans retinoic acid generate ex vivo transgenic regulatory T cells with intestinal homing receptors. Transplant. Proc. 41: 2670-2672 (2009). *

• Moore C, Sauma D, Reyes PA, Morales J, Rosemblatt M, Bono MR, Fierro JA. Dendritic cells and B cells cooperate in the generation of CD4(+)CD25(+)FOXP3(+) allogeneic T cells. Transplant. Proc. 42: 371-375 (2010).

• Moreira RK. Hepatic stellate cells and liver fibrosis. Arch. Pathol. Lab. Med. 131: 1728-1734 (2007). *

• Moreno M, Bataller R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin. Liver Dis. 12: 825-852, ix (2008).

• Moreno Sanchez D. Pathogenesis of primary nonalcoholic fatty liver disease. Med. Clin. (Barc.) 124: 668-677 (2005).

• Moretta L, Bottino C, Pende D, Vitale M, Mingari MC, Moretta A. Human natural killer cells: molecular mechanisms controlling NK cell activation and tumor cell lysis. Immunol. Lett. 100: 7-13 (2005).

• Mori S. Genomic approaches to bone and joint diseases. An order made medical system for management of osteoporosis : an attempt using genetic information. Clin. Calcium 18: 233-238 (2008).

• Mori S, Fuku N, Chiba Y, Tokimura F, Hosoi T, Kimbara Y, Tamura Y, Araki A, Tanaka M, Ito H. Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis. J. Bone Miner. Metab. Jan 7 [Epub ahead of print] (2010). *

• Mori T, Nomoto S, Koshikawa K, Fujii T, Sakai M, Nishikawa Y, Inoue S, Takeda S, Kaneko T, Nakao A. Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma. Liver Int. 25: 380-388 (2005). *

• Moriguchi H. A novel method in order to evaluate the efficacies and the safeties of new drugs for hepatocellular carcinoma with loss of transforming growth factor-beta signaling. Hepatology 50: 2050-2051 (2009).

• Morimoto Y, Gai Z, Tanishima H, Kawakatsu M, Itoh S, Nishioka K, Hatamura I, Muragaki Y. TNF-alpha deficiency accelerates renal tubular interstitial fibrosis in the late stage of ureteral obstruction. Exp. Mol. Pathol. 85: 207-213 (2008).

• Morin CI, Huot J. Recent advances in stress signaling in cancer. Cancer Res. 64: 1893-1898 (2004). *

• Morishima N, Mizoguchi I, Takeda K, Mizuguchi J, Yoshimoto T. TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem. Biophys. Res. Commun. 386: 105-110 (2009). *

• Morita H, Hayashi D, Nagai R. CTGF polymorphism associated with systemic sclerosis. N. Engl. J. Med. 358: 308 (2008).

• Moritoki Y, Lian ZX, Lindor K, Tuscano J, Tsuneyama K, Zhang W, Ueno Y, Dunn R, Kehry M, Coppel RL, Mackay IR, Gershwin ME. B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice. Hepatology 50: 1893-1903 (2009). *

• Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian ZX. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 136: 1037-1047 (2009). *

• Moseley RH. Progress in understanding the pathogenesis of nonalcoholic fatty liver disease. Hepatology 41: 204 (2005). *

• Moser M, Matthiesen S, Kirfel J, Schorle H, Bergmann C, Senderek J, Rudnik-Schoneborn S, Zerres K, Buettner R. A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD). Hepatology 41: 1113-1121 (2005). *

• Moss ML, White JM, Lambert MH, Andrews RC. TACE and other ADAM proteases as targets for drug discovery. Drug Discov. Today. 6: 417-426 (2001).

• Mossner R, Beckmann I, Hallermann C, Neumann C, Reich K. Granulocyte colony-stimulating-factor-induced psoriasiform dermatitis resembles psoriasis with regard to abnormal cytokine expression and epidermal activation. Exp. Dermatol. 13: 340-346 (2004). *

• Motomura K, Ohata M, Satre M, Tsukamoto H. Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease. Am. J. Physiol. Endocrinol. Metab. 281: E420-E429 (2001). *

• Motomura Y, Khan WI, El-Sharkawy RT, Verma-Gandhu M, Verdu EF, Gauldie J, Collins SM. Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein-1. Gut 55: 662-670 (2006). *

• Motomura Y, Wang H, Deng Y, El-Sharkawy RT, Verdu EF, Khan WI. Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis. Clin. Exp. Immunol. 155: 88-95 (2009). *

• Motoyama S, Miura M, Hinai Y, Maruyama K, Murata K, Ogawa JI. C-reactive protein -717C>T genetic polymorphism associates with esophagectomy-induced stress hyperglycemia. World J. Surg. Feb 10 [Epub ahead of print] (2010). *

• Mou HB, Lin MF, Cen H, Yu J, Meng XJ. TGF-beta1 treated murine dendritic cells are maturation resistant and down-regulate Toll-like receptor 4 expression. J. Zhejiang Univ. Sci. 5: 1239-1244 (2004). *

• Mouler Rechtman M, Nakaryakov A, Shapira KE, Ehrlich M, Henis YI. Different domains regulate homomeric and heteromeric complex formation among type I and type II TGF-beta receptors. J. Biol. Chem. 284: 7843-7852 (2009). *

• Mowat AM, Parker LA, Beacock-Sharp H, Millington OR, Chirdo F. Oral tolerance: overview and historical perspectives. Ann. N. Y. Acad. Sci. 1029: 1-8 (2004). *

• Mucida D, Cheroutre H. TGFbeta and retinoic acid intersect in immune-regulation. Cell. Adh. Migr. 1: 142-144 (2007). *

• Mucida D, Park Y, Cheroutre H. From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine. Semin. Immunol. 21: 14-21 (2009). *

• Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal Th-17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260 (2007). *

• Mucida D, Pino-Lagos K, Kim G, Nowak E, Benson MJ, Kronenberg M, Noelle RJ, Cheroutre H. Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity 30: 471-472 (2009). *

• Mucida D, Salek-Ardakani S. Regulation of TH17 cells in the mucosal surfaces. J. Allergy Clin. Immunol. 123: 997-1003 (2009). *

• Mudter J, Neurath MF. Mucosal T cells: mediators or guardians of inflammatory bowel disease? Curr. Opin. Gastroenterol. 19: 343-349 (2003).

• Mukherjee S, Schaller MA, Neupane R, Kunkel SL, Lukacs NW. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J. Immunol. 182: 7381-7388 (2009).

• Mullan RJ, Bergstralh EJ, Farmer SA, Jacobson DJ, Hebbring SJ, Cunningham JM, Thibodeau SN, Lieber MM, Jacobsen SJ, Roberts RO. Growth factor, cytokine, and vitamin D receptor polymorphisms and risk of benign prostatic hyperplasia in a community-based cohort of men. Urology 67: 300-305 (2006).

• Mulsow JJ, Watson RW, Fitzpatrick JM, O'Connell PR. Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling. Ann. Surg. 242: 880-889 (2005). *

• Munshi HG, Wu YI, Mukhopadhyay S, Ottaviano AJ, Sassano A, Koblinski JE, Platanias LC, Stack MS. Differential regulation of membrane-type 1 matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls TGF-beta1-induced pericellular collagenolysis. J. Biol. Chem. 279: 39042-39050 (2004). *

• Murakozy G, Gaede KI, Ruprecht B, Gutzeit O, Schurmann M, Schnabel A, Schlaak M, Gross WL, Muller-Quernheim J. Gene polymorphisms of immunoregulatory cytokines and angiotensin-converting enzyme in Wegener's granulomatosis. J. Mol. Med. 79: 665-670 (2001). *

• Murray NR, Weems C, Chen L, Leon J, Yu W, Davidson LA, Jamieson L, Chapkin RS, Thompson EA, Fields AP. Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. J. Cell. Biol. 157: 915-920 (2002). *

• Murthy AK, Sharma J, Coalson JJ, Zhong G, Arulanandam BP. Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice. Cell. Immunol. 230: 56-64 (2004). *

• Mus AM, Cornelissen F, Asmawidjaja PS, van Hamburg JP, Boon L, Hendriks RW, Lubberts E. IL-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for IL-22 but not IL-21 in autoimmune experimental arthritis. Arthritis Rheum. Jan 21 [Epub ahead of print] (2010). *

• Musso T, Scutera S, Vermi W, Daniele R, Fornaro M, Castagnoli C, Alotto D, Ravanini M, Cambieri I, Salogni L, Elia AR, Giovarelli M, Facchetti F, Girolomoni G, Sozzani S. Activin A induces Langerhans cell differentiation in vitro and in human skin explants. PLoS ONE 3: e3271 (2008). *

• Myung SJ, Yoon JH, Gwak GY, Kim W, Yang JI, Lee SH, Jang JJ, Lee HS. Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation. Biochem. Biophys. Res. Commun. 353: 1091-1096 (2007). *

• Na X, Zhao D, Koon HW, Kim H, Husmark J, Moyer MP, Pothoulakis C, Lamont JT. Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology 128: 1002-1011 (2005). *

• Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J. Exp. Med. 204: 33-39 (2007). *

• Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB. Cutting edge: critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J. Immunol. 177: 2765-2769 (2006). *

• Nagasawa T, Inada Y, Nakano S, Tamura T, Takahashi T, Maruyama K, Yamazaki Y, Kuroda J, Shibata N. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. Eur. J. Pharmacol. 536: 182-191 (2006). *

• Nagata H, Hatano E, Tada M, Murata M, Kitamura K, Asechi H, Narita M, Yanagida A, Tamaki N, Yagi S, Ikai I, Matsuzaki K, Uemoto S. Inhibition of c-Jun NH(2)-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma. Hepatology 49: 1944-1953 (2009). *

• Nagata S, McKenzie C, Pender SL, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, Monteleone G, MacDonald TT. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J. Immunol. 165: 5315-5321 (2000). *

• Nagata Y, Inoue H, Yamada K, Higashiyama H, Mishima K, Kizu Y, Takeda I, Mizuno F, Hayashi Y, Saito I. Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients. Immunology 111: 223-229 (2004). *

• Nakamura T, Ueno T, Sakamoto M, Sakata R, Torimura T, Hashimoto O, Ueno H, Sata M. Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury. J. Hepatol. 41: 974-982 (2004). *

• Nakamuta M, Morizono S, Tsuruta S, Kohjima M, Kotoh K, Enjoji M. Remote delivery and expression of soluble type II TGF-beta receptor in muscle prevents hepatic fibrosis in rats. Int. J. Mol. Med. 16: 59-64 (2005).

• Nakano N, Hosokawa H, Kohyama M, Hozumi N. NF-AT-mediated expression of TGF-beta1 in tolerant T cells. J. Immunol. 178: 3067-3075 (2007). *

• Nakano S, Nagasawa T, Ijiro T, Inada Y, Tamura T, Maruyama K, Kuroda J, Yamazaki Y, Kusama H, Shibata N. Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-beta1 in a cultured stellate cell line. Hepatol. Res. 38: 1026-1039 (2008). *

• Nakanuma Y, Sato Y, Kiktao A. Pathology and pathogenesis of portal venopathy in idiopathic portal hypertension: hints from systemic sclerosis. Hepatol. Res. 39: 1023-1031 (2009). *

• Nakashima S, Katano Y, Nakano I, Hirooka Y, Ito A, Ishigami M, Hayashi K, Honda T, Goto H. Changes in circulating cytokine levels and lymphocyte subsets in healthy liver donors after partial hepatectomy. Hepatol. Res. 37: 878-884 (2007). *

• Nakatsuji Y, Nakano M, Moriya M, Kishigami H, Tatsumi C, Tada S, Sadahiro S, Naka T, Mitani K, Funauchi M, Azuma T, Watanabe S, Kinoshita M, Kajiyama K, Yuasa Y, Kaido M, Takahashi M, Naba I, Hazama T, Sakoda S; Osaka Neurological Research Consortium. Beneficial effect of interferon-beta treatment in patients with multiple sclerosis is associated with transient increase in serum IL-6 level in response to interferon-beta injection. Cytokine 36: 69-74 (2006).

• Nakken KE, Nygard S, Haaland T, Berge KE, Arnkvaern K, Odegaard A, Labori KJ, Raeder MG. Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis. Scand. J. Gastroenterol. 42: 1245-1255 (2007). *

• Nakken KE, Nygard S, Haaland TK, Berge KE, Odegaard A, Labori KJ, Raeder MG. Gene expression profiles reflect sclerosing cholangitis activity in abcb4 (-/-) mice. Scand. J. Gastroenterol. 44: 211-218 (2009). *

• Nalbandian A, Crispín JC, Tsokos BC. IL-17 and systemic lupus erythematosus: current concepts. Clin. Exp. Immunol. 157: 209-215 (2009). *

• Nam JS, Terabe M, Kang MJ, Chae H, Voong N, Yang YA, Laurence A, Michalowska A, Mamura M, Lonning S, Berzofsky JA, Wakefield LM. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 68: 3915-3923 (2008). *

• Nam JS, Terabe M, Mamura M, Kang MJ, Chae H, Stuelten C, Kohn E, Tang B, Sabzevari H, Anver MR, Lawrence S, Danielpour D, Lonning S, Berzofsky JA, Wakefield LM. An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68: 3835-3843 (2008). *

• Nanakin A, Fukui H, Fujii S, Sekikawa A, Kanda N, Hisatsune H, Seno H, Konda Y, Fujimori T, Chiba T. Expression of the REG IV gene in ulcerative colitis. Lab. Invest. 87: 304-314 (2007). *

• Nanda Kumar NS, Balamurugan R, Jayakanthan K, Pulimood A, Pugazhendhi S, Ramakrishna BS. Probiotic administration alters the gut flora and attenuates colitis in mice administered dextran sodium sulfate. J. Gastroenterol. Hepatol. 23: 1834-1839 (2008). *

• Nandula SR, Amarnath S, Molinolo A, Bandyopadhyay BC, Hall B, Goldsmith CM, Zheng C, Larsson J, Sreenath T, Chen W, Ambudkar IS, Karlsson S, Baum BJ, Kulkarni AB. Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum. 56: 1798-1805 (2007). *

• Napoli J, Bishop GA, McCaughan GW. Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis. Gastroenterology 107: 789-798 (1994).

• Narayanan BA. Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. Curr. Cancer Drug Targets 6: 711-727 (2006).

• Nardelli DT, Kevin Luk KH, Kotloski NJ, Warner TF, Torrealba JR, Callister SM, Schell RF. Role of IL-17, transforming growth factor-beta, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice. FEMS Immunol. Med. Microbiol. 53: 265-274 (2008). *

• Nataraja S, Kagan D, Clark A, Palmer S. Cytokines and growth factors inhibit tumor necrosis factor alpha-induced up-regulation of fibronectin binding on bovine endometrial cells. Fertil. Steril. 89: S1422-S1429 (2008). *

• Nathens AB, Rotstein OD, Dackiw AP, Marshall JC. Intestinal epithelial cells down-regulate macrophage tumor necrosis factor-alpha secretion: a mechanism for immune homeostasis in the gut-associated lymphoid tissue. Surgery 118: 343-350 (1995).

• Nearman ZP, Wlodarski M, Jankowska AM, Howe E, Narvaez Y, Ball E, Maciejewski JP. Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias. Br. J. Haematol. 136: 237-248 (2007). *

• Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, Benmohamed L. Functional Foxp3+ CD4+CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. J. Virol. 81: 7647-7661 (2007). *

• Neth P, Ries C, Karow M, Egea V, Ilmer M, Jochum M. The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion. Stem Cell Rev. 3: 18-29 (2007).

• Neubauer K, Lindhorst A, Tron K, Ramadori G, Saile B. Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and TNF-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes. BMC Physiol. 8: 9 (2008). *

• Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 37: 1809-1816 (2007). *

• Neuman M, Angulo P, Malkiewicz I, Jorgensen R, Shear N, Dickson ER, Haber J, Katz G, Lindor K. Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis. J. Gastroenterol. Hepatol. 17: 196-202 (2002). *

• Neuman MG. Cytokines - central factors in alcoholic liver disease. Alcohol Res. Health 27: 307-316 (2003). *

• Neunlist M, Aubert P, Bonnaud S, Van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP. Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G231-G241 (2007). *

• Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J. Exp. Med. 183: 2605-2616 (1996). *

• Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, Iijima H, Mizoguchi A, Mizoguchi E, Mudter J, Galle PR, Bhan A, Autschbach F, Sullivan BM, Szabo SJ, Glimcher LH, Blumberg RS. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195: 1129-1143 (2002). *

• Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 182: 5317-5321 (2009).

• Nguyen CQ, Sharma A, She JX, McIndoe RA, Peck AB. Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjogren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Exp. Eye Res. 88: 398-409 (2009).

• Nguyen DD, Snapper SB. Targeting Smads to restore transforming growth factor-beta signaling and regulatory T-cell function in inflammatory bowel disease. Gastroenterology 136: 1161-1164 (2009). *

• Nguyen LN, Furuya MH, Wolfraim LA, Nguyen AP, Holdren MS, Campbell JS, Knight B, Yeoh GC, Fausto N, Parks WT. Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology 45: 31-41 (2007). *

• Nguyen S, Morel V, Le Garff-Tavernier M, Bolgert F, Leblond V, Debre P, Vieillard V. Persistence of CD16+/CD56-/2B4+ natural killer cells: a highly dysfunctional NK subset expanded in ocular myasthenia gravis. J. Neuroimmunol. 179: 117-125 (2006).

• Nguyen Van N, Taglinger K, Helps CR, Tasker S, Gruffydd-Jones TJ, Day MJ. Measurement of cytokine mRNA expression in intestinal biopsies of cats with inflammatory enteropathy using quantitative real-time RT-PCR. Vet. Immunol. Immunopathol. 113: 404-414 (2006). *

• Nicholas SB, Liu J, Kim J, Ren Y, Collins AR, Nguyen L, Hsueh WA. Critical role for osteopontin in diabetic nephropathy. Kidney Int. Feb 3 [Epub ahead of print] (2010). *

• Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clin. Rev. Allergy Immunol. 34: 146-162 (2008). *

• Nickoloff BJ, Ben-Neriah Y, Pikarsky E. Inflammation and cancer: is the link as simple as we think? J. Invest. Dermatol. 124: x-xiv (2005). *

• Nickoloff BJ, Naidu Y. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J. Am. Acad. Dermatol. 30: 535-546 (1994).

• Nicodeme F, Geffroy S, Conti M, Delobel B, Soenen V, Grardel N, Porte H, Copin MC, Lai JL, Andrieux J. Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3). Genes Chromosomes Cancer 44: 154-160 (2005). *

• Niedbala W, Cai B, Liu H, Pitman N, Chang L, Liew FY. Nitric oxide induces CD4+CD25+ Foxp3- regulatory T cells from CD4+CD25- T cells via p53, IL-2, and OX40. Proc. Natl. Acad. Sci. U.S.A. 104: 15478-15483 (2007). *

• Niederkorn JY. Emerging concepts in CD8(+) T regulatory cells. Curr. Opin. Immunol. 20: 327-331 (2008).

• Niederkorn JY. Mechanisms of immune privilege in the eye and hair follicle. J. Investig. Dermatol. Symp. Proc. 8: 168-172 (2003). *

• Nieminen K, Valovirta E, Savolainen J. Clinical outcome and IL-17, IL-23, IL-27 and FOXP3 expression in peripheral blood mononuclear cells of pollen-allergic children during sublingual immunotherapy. Pediatr. Allergy Immunol. Jun 29 [Epub ahead of print] (2009). *

• Nieto N, Cederbaum AI. S-Adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J. Biol. Chem. 280: 30963-30974 (2005). *

• Nikolova PN, Ivanova MI, Mihailova SM, Myhailova AP, Baltadjieva DN, Simeonov PL, Paskalev EK, Naumova EJ. Cytokine gene polymorphism in kidney transplantation - impact of TGF-beta1, TNF-alpha and IL-6 on graft outcome. Transpl. Immunol. 18: 344-348 (2008).

• Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 37: 766-776 (1995). *

• Nilsson J, Boasso A, Velilla PA, Zhang R, Vaccari M, Franchini G, Shearer GM, Andersson J, Chougnet C. HIV-1 driven regulatory T cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 108: 3808-3817 (2006). *

• Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702 (2007). *

• Nishimura T, Azuma T, Yokoyama A, Ochiai H, Saito H, Hibi T. New mechanism of transforming growth factor-beta signaling in hepatoma: dramatic up-regulation of tumor initiating cells and epidermal growth factor receptor expression. Hepatol. Res. 39: 501-509 (2009).

• Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima K, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Azuma S, Sekine-Osajima Y, Kakinuma S, Tsuchiya K, Enomoto N, Tanaka H, et al. Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells. J. Gastroenterol. Dec 17 [Epub ahead of print] (2009). *

• Nissinen R, Leirisalo-Repo M, Nieminen AM, Halme L, Farkkila M, Palosuo T, Vaarala O. Immune activation in the small intestine in patients with rheumatoid arthritis. Ann. Rheum. Dis. 63: 1327-1330 (2004). *

• No authors listed. In this issue. Eur. J. Immunol. 39: 628-629 (2009). *

• No authors listed. In this issue. Eur. J. Immunol. 39: 919-920 (2009).

• No authors listed. In this issue. Eur. J. Immunol. 39: 2308-2309 (2009). *

• No authors listed. In this issue. Eur. J. Immunol. 39: 3274-3275 (2009). *

• No authors listed. Genetic predisposition to multiple sclerosis as a polygenic autoimmune disease. Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 109: S16-S22 (2009).

• Noda M, Rodan GA. Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone. J. Cell Biol. 108: 713-718 (1989).

• Noda M, Vogel RL, Craig AM, Prahl J, DeLuca HF, Denhardt DT. Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. U.S.A. 87: 9995-9999 (1990). *

• Noda M, Yoon K, Prince CW, Butler WT, Rodan GA. Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor. J. Biol. Chem. 263: 13916-13921 (1988). *

• Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J. Exp. Med. 206: 2131-2139 (2009). *

• Nomoto S, Kinoshita T, Mori T, Kato K, Sugimoto H, Kanazumi N, Takeda S, Nakao A. Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer. Br. J. Cancer 98: 1690-1695 (2008). *

• Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. Gastroenterology 128: 1292-1305 (2005). *

• Noori-Daloii MR, Rashidi-Nezhad A, Izadi P, Hossein-Nezhad A, Sobhani M, Derakhshandeh-Peykar P, Alimoghaddam K, Ghavamzadeh A. Transforming growth factor-beta1 codon 10 polymorphism is associated with acute GVHD after allogenic BMT in Iranian population. Ann. Transplant. 12: 5-10 (2007).

• Noto T, Yamada H, Inui T, Okuyama K, Watanable A, Kimura I, Nagasaki M. Therapeutic effects of ecabet sodium, an antiulcer drug, on dextran sodium sulfate-induced ulcerative colitis in rats. Dig. Dis. Sci. 50: 922-927 (2005). *

• Nouri-Aria KT, Durham SR. Regulatory T cells and allergic disease. Inflamm. Allergy Drug Targets 7: 237-252 (2008).

• Novitskiy G, Potter JJ, Wang L, Mezey E. Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis. Liver Int. 26: 1248-1257 (2006). *

• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-1831 (2008). *

• Novoselov SV, Calvisi DV, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN. Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene 24: 8003-8011 (2005). *

• Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, Schreiner B, Coyle AJ, Kasper LH, Noelle RJ. IL-9 as a mediator of Th17-driven inflammatory disease. J. Exp. Med. 206: 1653-1660 (2009). *

• Nowak J, Weylandt KH, Habbel P, Wang J, Dignass A, Glickman JN, Kang JX. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 28: 1991-1995 (2007). *

• Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res. Ther. 11: R174 (2009). *

• Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-484 (2007). *

• Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149 (2008). *

• Nuzzo D, Cataldo F, Forte GI, Scola L, Crivello A, Giacalone A, Accomando S, Barbieri R, Candore G, Caruso C, Lio D. Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genes? Rejuvenation Res. 9: 153-156 (2006).

• O'Connell MA, Rushworth SA. Curcumin: potential for hepatic fibrosis therapy? Br. J. Pharmacol. 153: 403-405 (2008). *

• O'Garra A, Murphy K. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5: 880-886 (1993).

• O'Garra A, Steinman L, Gijbels K. CD4+ T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9: 872-883 (1997).

• O'Garra A, Stockinger B, Veldhoen M. Differentiation of human T(H)-17 cells does require TGF-beta! Nat. Immunol. 9: 588-590 (2008). *

• O'Mahony L, O'Callaghan L, McCarthy J, Shilling D, Scully P, Sibartie S, Kavanagh E, Kirwan WO, Redmond HP, Collins JK, Shanahan F. Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G839-G845 (2006). *

• O'Malley JT, Sehra S, Thieu VT, Yu Q, Chang HC, Stritesky GL, Nguyen ET, Mathur AN, Levy DE, Kaplan MH. Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology 127: 587-595 (2009). *

• Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 53: 438-445 (2004). *

• Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso A, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. J. Neurol. Sci. 274: 9-12 (2008).

• Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4(+)CD25(-)LAP(+) T cells. Nat. Med. 12: 627-635 (2006). *

• Ochoa-Reparaz J, Riccardi C, Rynda A, Jun S, Callis G, Pascual DW. Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis. J. Immunol. 178: 1791-1799 (2007). *

• Ochoa-Reparaz J, Rynda A, Ascon MA, Yang X, Kochetkova I, Riccardi C, Callis G, Trunkle T, Pascual DW. IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen. J. Immunol. 181: 954-968 (2008). *

• Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J. Allergy Clin. Immunol. 123: 977-983 (2009). *

• Oe S, Lemmer ER, Conner EA, Factor VM, Leveen P, Larsson J, Karlsson S, Thorgeirsson SS. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 40: 1098-1105 (2004). *

• Oen K, Malleson PN, Cabral DA, Rosenberg AM, Petty RE, Nickerson P, Reed M. Cytokine genotypes correlate with pain and radiologically defined joint damage in patients with juvenile rheumatoid arthritis. Rheumatology (Oxford) 44: 1115-1121 (2005). *

• Oertelt S, Lian ZX, Cheng CM, Chuang YH, Padgett KA, He XS, Ridgway WM, Ansari AA, Coppel RL, Li MO, Flavell RA, Kronenberg M, Mackay IR, Gershwin ME. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J. Immunol. 177: 1655-1660 (2006). *

• Oertelt S, Ridgway WM, Ansari AA, Coppel RL, Gershwin ME. Murine models of primary biliary cirrhosis: comparisons and contrasts. Hepatol. Res. 37 Suppl. 3: S365-S369 (2007). *

• Oertelt-Prigione S, Mao TK, Selmi C, Tsuneyama K, Ansari AA, Coppel RL, Invernizzi P, Podda M, Gershwin ME. Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis. Autoimmunity 41: 92-99 (2008).

• Offenberg H, Brunner N, Mansilla F, Orntoft Torben F, Birkenkamp-Demtroder K. TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles. Mol. Oncol. 2: 233-240 (2008).

• Ogawa N, Shimoyama K, Kawanami T. Molecular mechanisms of salivary gland destruction in patients with Sjogren's syndrome. Nihon Rinsho Meneki Gakkai Kaishi 28: 10-20 (2005).

• Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, Matsumoto Y, Kawakita T, Okamoto S, Tsubota K. Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. Bone Marrow Transplant. Jul 27 [Epub ahead of print] (2009).

• Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am. J. Physiol. 272: G589-G969 (1997). *

• Ohga S, Shikata K, Yozai K, Okada S, Ogawa D, Usui H, Wada J, Shikata Y, Makino H. Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. Am. J. Physiol. Renal Physiol. 292: F1141-F1150 (2007). *

• Ohsugi Y. Recent advances in IL-6 related to autoimmunity. The Scientist May, 2007 (http://www.the-scientist.com/2007/05/01/s37/1/) (2007).

• Ohtani K, Ohstuka Y, Ikuse T, Baba Y, Yamakawa Y, Aoyagi Y, Fujii T, Kudo T, Nagata S, Shimizu T. Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. Pediatr. Int. Dec 17 [Epub ahead of print] (2009).

• Ohtani T, Mizuashi M, Nakagawa S, Sasaki Y, Fujimura T, Okuyama R, Aiba S. TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology 126: 485-499 (2009). *

• Ohtsuka T, Yamakage A, Yamazaki S. The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis. Br. J. Dermatol. 147: 458-463 (2002). *

• Oi M, Yamamoto T, Nishioka K. Increased expression of TGF-beta1 in the sclerotic skin in bleomycin-'susceptible' mouse strains. J. Med. Dent. Sci. 51: 7-17 (2004).

• Oida T, Xu L, Weiner HL, Kitani A, Strober W. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J. Immunol. 177: 2331-2339 (2006). *

• Okamoto H, Kimura M, Watanabe N, Ogihara M. Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-alpha. Eur. J. Pharmacol. 604: 12-19 (2009).

• Okamoto T, Yamada T, Kuno A, Ogawa K, Tang M, Sano H, Ohara H, Nakao H, Kataoka H, Shirai T, Itoh M. FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. Pancreas 30: e64-e70 (2005).

• Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez FJ, Aoyama T. Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. J. Hepatol. 50: 1236-1246 (2009).

• Oko L, Aduddell-Swope B, Willis D, Hamor R, Coons TA, Hjelle B, Schountz T. Profiling helper T cell subset gene expression in deer mice. BMC Immunol. 7: 18 (2006). *

• Okoshi K, Kubo H, Nagayama S, Tabata C, Kadokawa Y, Hisamori S, Yonenaga Y, Fujimoto A, Mori A, Onodera H, Watanabe G, Sakai Y. All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice. J. Surg. Res. 150: 53-59 (2008).

• Oksanen AM, Haimila KE, Rautelin HI, Partanen JA. Immunogenetic characteristics of patients with autoimmune gastritis. World J. Gastroenterol. 16: 354-358 (2010). *

• Okumura A, Ishikawa T, Sato S, Yamauchi T, Oshima H, Ohashi T, Sato K, Ayada M, Hotta N, Kakumu S. Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4CD25 T cells in patients with autoimmune hepatitis. Hepatol. Res. 38: 896-903 (2008). *

• Okuno M, Sato T, Kitamoto T, Imai S, Kawada N, Suzuki Y, Yoshimura H, Moriwaki H, Onuki K, Masushige S, Muto Y, Friedman SL, Kato S, Kojima S. Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo. J. Hepatol. 30: 1073-1080 (1999). *

• Olas K, Butterweck H, Teschner W, Schwarz HP, Reipert B. Immunomodulatory properties of human serum immunoglobulin A: anti-inflammatory and pro-inflammatory activities in human monocytes and peripheral blood mononuclear cells. Clin. Exp. Immunol. 140: 478-490 (2005). *

• Omrani MD, Taghipour-Bazargani S, Salari-Lak S, Bagheri M. Association of codon 10 polymorphism of the transforming growth factor beta 1 gene with prostate cancer and hyperplasia in an Iranian population. Urol. Int. 83: 329-332 (2009).

• Orgun NN, Mathis MA, Wilson CB, Way SS. Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells. J. Immunol. 180: 4109-4115 (2008). *

• Ornatowski W, Poschet JF, Perkett E, Taylor-Cousar JL, Deretic V. Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity. J. Clin. Invest. 117: 3489-3497 (2007). *

• Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 26: 1138-1147 (2006). *

• Oshitani N, Watanabe K, Nakamura S, Fujiwara Y, Higuchi K, Arakawa T. Dislocation of tight junction proteins without F-actin disruption in inactive Crohn's disease. Int. J. Mol. Med. 15: 407-410 (2005).

• Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B. Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterol. 6: 31 (2006). *

• Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis. Cytokine 31: 142-148 (2005).

• Osterreicher CH, Halangk J, Berg T, Patsenker E, Homann N, Hellerbrand C, Seitz HK, Eurich D, Stickel F. Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease. Cytokine 42: 18-23 (2008).

• Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A. Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J. Clin. Invest. 116: 996-1004 (2006). *

• Ostroukhova M, Ray A. CD25+ T cells and regulation of allergen-induced responses. Curr. Allergy Asthma Rep. 5: 35-41 (2005).

• Ota T, Takamura T, Kurita S, Matsuzawa N, Kita Y, Uno M, Akahori H, Misu H, Sakurai M, Zen Y, Nakanuma Y, Kaneko S. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology 132: 282-293 (2007). *

• Ou-Yang HF, Hu XB, Ti XY, Shi JR, Li SJ, Qi HW, Wu CG. Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG. Immunology 128: e343-e352 (2009). *

• Ouaked N, Mantel PY, Bassin C, Burgler S, Siegmund K, Akdis CA, Schmidt-Weber CB. Regulation of the Foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. J. Immunol. 182: 1041-1049 (2009).

• Oukka M. Interplay between pathogenic Th17 and regulatory T cells. Ann. Rheum. Dis. 66 Suppl. 3: iii87-iii90 (2007).

• Oukka M. Th17 cells in immunity and autoimmunity. Ann. Rheum. Dis. 67 Suppl. 3: iii26-iii29 (2008).

• Ouwehand AC, Bergsma N, Parhiala R, Lahtinen S, Gueimonde M, Finne-Soveri H, Strandberg T, Pitkala K, Salminen S. Bifidobacterium microbiota and parameters of immune function in elderly subjects. FEMS Immunol. Med. Microbiol. 53: 18-25 (2008). *

• Owen CR, Yuan L, Basson MD. Smad3 knockout mice exhibit impaired intestinal mucosal healing. Lab. Invest. 88: 1101-1109 (2008). *

• Oz HS, Im HJ, Chen TS, de Villiers WJ, McClain CJ. Glutathione-enhancing agents protect against steatohepatitis in a dietary model. J. Biochem. Mol. Toxicol. 20: 39-47 (2006). *

• Oz HS, Ray M, Chen TS, McClain CJ. Efficacy of a transforming growth factor beta2 containing nutritional support formula in a murine model of inflammatory bowel disease. J. Am. Coll. Nutr. 23: 220-226 (2004). *

• Paajanen L, Kokkonen J, Karttunen TJ, Tuure T, Korpela R, Vaarala O. Intestinal cytokine mRNA expression in delayed-type cow's milk allergy. J. Pediatr. Gastroenterol. Nutr. 43: 470-476 (2006). *

• Paajanen L, Korpela R, Tuure T, Honkanen J, Jarvela I, Ilonen J, Knip M, Vaarala O, Kokkonen J. Cow milk is not responsible for most gastrointestinal immune-like syndromes - evidence from a population-based study. Am. J. Clin. Nutr. 82: 1327-1335 (2005). *

• Packer A. Cancer genetics. Second-generation models. Nat. Rev. Genet. 5: 888 (2004). *

• Paclik D, Lohse K, Wiedenmann B, Dignass AU, Sturm A. Galectin-2 and -4, but not Galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism. Inflamm. Bowel Dis. 14: 1366-1372 (2008). *

• Paduch R, Niedziela P. TGF-beta1 influence on TNF-alpha production and sTNF-Rs shedding in a coculture of colon carcinoma cell spheroids with normal cells. In Vitro Cell. Dev. Biol. Anim. 45: 371-377 (2009). *

• Paidipally P, Periasamy S, Barnes PF, Dhiman R, Indramohan M, Griffith DE, Cosman D, Vankayalapati R. NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen. J. Immunol. 183: 1940-1945 (2009).

• Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, Ahn SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS, Brenner D. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut 58: 1517-1527 (2009).

• Paladino N, Flores AC, Fainboim H, Schroder T, Cuarterolo M, Lezama C, Ballerga EG, Levi D, Tanno H, Costanzo G, Arruvito L, Fainboim L. The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-beta1. Clin. Immunol. Dec 3 [Epub ahead of print] (2009). *

• Pallone F, Del Vecchio Blanco G, Vavassori P, Monteleone I, Fina D, Monteleone G. Genetic and pathogenetic insights into inflammatory bowel disease. Curr. Gastroenterol. Rep. 5: 487-492 (2003).

• Pan PH, Lin SY, Ou YC, Chen WY, Chuang YH, Yen YJ, Liao SL, Raung SL, Chen CJ. Stearic acid attenuates cholestasis-induced liver injury. Biochem. Biophys. Res. Commun. Dec 24 [Epub ahead of print] (2009). *

• Pan X, Wang X, Lei W, Min L, Yang Y, Wang X, Song J. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 50: 1577-1587 (2009).

• Pandey JP, LeRoy EC. A profibrotic polymorphism (of TGFbeta1) in systemic sclerosis. Ann. Rheum. Dis. 61: 671-672 (2002). *

• Panja A, Siden E, Mayer L. Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells. Clin. Exp. Immunol. 100: 298-305 (1995). *

• Panoulas VF, Douglas KM, Smith JP, Stavropoulos-Kalinoglou A, Metsios GS, Nightingale P, Kitas GD. Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis. Rheumatology (Oxford) 48: 113-118 (2009). *

• Papacleovoulou G, Edmondson RJ, Critchley HO, Hillier SG, Mason JI. 3beta-Hydroxysteroid dehydrogenases and pre-receptor steroid metabolism in the human ovarian surface epithelium. Mol. Cell. Endocrinol. 301: 65-73 (2009).

• Paradis V, Bieche I, Dargere D, Cazals-Hatem D, Laurendeau I, Saada V, Belghiti J, Bezeaud A, Vidaud M, Bedossa P, Valla DC. Quantitative gene expression in Budd-Chiari syndrome: a molecular approach to the pathogenesis of the disease. Gut 54: 1776-1781 (2005). *

• Paradowska A, Masliniski W, Grzybowska-Kowalczyk A, Lacki J. The function of interleukin 17 in the pathogenesis of rheumatoid arthritis. Arch. Immunol. Ther. Exp. (Warsz.) 55: 329-334 (2007). *

• Parent R, Kolippakkam D, Booth G, Beretta L. Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth. Cancer Res. 67: 4337-4345 (2007). *

• Park CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y, Breyer MD. Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. Diabetes 55: 885-893 (2006). *

• Park HB, Paik DJ, Jang E, Hong S, Youn J. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells. Int. Immunol. 16: 1203-1213 (2004). *

• Park HJ, Ye YM, Hur GY, Kim SH, Park HS. Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population. J. Clin. Pharm. Ther. 33: 691-697 (2008). *

• Park IK, Shultz LD, Letterio JJ, Gorham JD. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J. Immunol. 175: 5666-5674 (2005). *

• Park JK, Ki MR, Lee HR, Hong IH, Ji AR, Ishigami A, Park SI, Kim JM, Chung HY, Yoo SE, Jeong KS. Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology Dec 9 [Epub ahead of print] (2009). *

• Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY. Type II collagen oral tolerance: mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod. Rheumatol. 19: 581-589 (2009). *

• Park L, Lee E, Lee S, Lim M, Hong H, Shin G, Park Y. TGFbeta plasmid construction and delivery for the prevention of type 1 diabetes. Ann. N. Y. Acad. Sci. 1150: 177-182 (2008). *

• Park SR, Kim HA, Chun SK, Park JB, Kim PH. Mechanisms underlying the effects of LPS and activation-induced cytidine deaminase on IgA isotype expression. Mol. Cells 19: 445-451 (2005). *

• Park SS, Lillehoj HS, Allen PC, Park DW, FitzCoy S, Bautista DA, Lillehoje EP. Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis. Avian Dis. 52: 14-22 (2008).

• Park SY, Jung MY, Kim HJ, Lee SJ, Kim SY, Lee BH, Kwon TH, Park RW, Kim IS. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ. 15: 192-201 (2008). *

• Park SY, Kang KB, Thapa N, Kim SY, Lee SJ, Kim IS. Requirement of adapter protein GULP during stabilin-2-mediated cell corpse engulfment. J. Biol. Chem. 283: 10593-10600 (2008). *

• Partridge CR, He Q, Brun M, Ramos KS. Genetic networks of cooperative redox regulation of osteopontin. Matrix Biol. 27: 462-474 (2008).

• Pascual DW, Ochoa-Reparaz J, Rynda A, Yang X. Tolerance in the absence of autoantigen. Endocr. Metab. Immune Disord. Drug Targets 7: 203-210 (2007).

• Passos ST, Silver JS, O'Hara AC, Sehy D, Stumhofer JS, Hunter CA. IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Pasztoi M, Nagy G, Geher P, Lakatos T, Toth K, Wellinger K, Pocza P, Gyorgy B, Holub MC, Kittel A, Paloczy K, Mazan M, Nyirkos P, Falus A, Buzas EI. Gene expression and activity of cartilage-degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts. Arthritis Res. Ther. 11: R68 (2009). *

• Patou J, Gevaert P, Van Zele T, Holtappels G, van Cauwenberge P, Bachert C. Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J. Allergy Clin. Immunol. 121: 110-115 (2008). *

• Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology 135: 660-670 (2008). *

• Patton DT, Garden OA, Pearce WP, Clough LE, Monk CR, Leung E, Rowan WC, Sancho S, Walker LS, Vanhaesebroeck B, Okkenhaug K. Cutting edge: the phosphoinositide 3-kinase p110delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J. Immunol. 177: 6598-6602 (2006). *

• Paus R, Ito N, Takigawa M, Ito T. The hair follicle and immune privilege. J. Investig. Dermatol. Symp. Proc. 8: 188-194 (2003). *

• Paus R, Nickoloff BJ, Ito T. A 'hairy' privilege. Trends Immunol. 26: 32-40 (2005). *

• Pearson AL, Colville-Nash P, Kwan JT, Dockrell ME. Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells. J. Nephrol. 21: 887-893 (2008).

• Pedroja BS, Kang LE, Imas AO, Carmeliet P, Bernstein AM. Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. J. Biol. Chem. 284: 20708-20717 (2009). *

• Pena AS, Crusius JB. Food allergy, coeliac disease and chronic inflammatory bowel disease in man. Vet. Q. 20 Suppl. 3: S49-S52 (1998).

• Peng J, Dicker B, Du W, Tang F, Nguyen P, Geiger T, Wong FS, Wen L. Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J. Autoimmun. 28: 188-200 (2007).

• Peng XD, Dai LL, Huang CQ, He CM, Chen LJ. Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J. Gastroenterol. 15: 4720-4725 (2009). *

• Peng Y, Han G, Shao H, Wang Y, Kaplan HJ, Sun D. Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 48: 4153-4161 (2007). *

• Penton-Rol G, Cervantes-Llanos M, Cabrera-Gomez JA, Alonso-Ramirez R, Valenzuela-Silva C, Rodriguez-Lara R, Montero-Casimiro E, Bello-Rivero I, Lopez-Saura P. Treatment with type I interferons induces a regulatory T cell subset in peripheral blood mononuclear cells from multiple sclerosis patients. Int. Immunopharmacol. 8: 881-886 (2008).

• Pereira FA, da Silva NN, Rodart IF, Carmo TM, Lemaire DC, Reis MG. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. J. Med. Virol. 80: 58-64 (2007). *

• Pereira RM, Dos Santos RA, Teixeira MM, Leite VH, Costa LP, da Costa Dias FL, Barcelos LS, Collares GB, Simoes E Silva AC. The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of angiotensin-(1-7). J. Hepatol. 46: 674-681 (2007). *

• Perez de Lema G, Lucio-Cazana FJ, Molina A, Luckow B, Schmid H, de Wit C, Moreno-Manzano V, Banas B, Mampaso F, Schlondorff D. Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease. Kidney Int. 66: 1018-1028 (2004). *

• Perez DS, Handa RJ, Yang RS, Campain JA. Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J. Appl. Toxicol. 28: 491-508 (2008). *

• Perez-Cano FJ, Ramirez-Santana C, Molero-Luis M, Castell M, Rivero M, Castellote C, Franch A. Mucosal IgA increase in rats by continuous CLA feeding during suckling and early infancy. J. Lipid Res. 50: 467-476 (2009). *

• Perez-Rojas JM, Bobadilla NA. Novel action of aldosterone in CsA nephrotoxicity. Rev. Invest. Clin. 57: 147-155 (2005).

• Perkett EA, Ornatowski W, Poschet JF, Deretic V. Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells. Pediatr. Pulmonol. 41: 771-778 (2006).

• Perrier S, Coussediere C, Dubost JJ, Albuisson E, Sauvezie B. IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjogren's syndrome and rheumatoid arthritis. Clin. Immunol. Immunopathol. 87: 309-313 (1998). *

• Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat. Med. 14: 528-535 (2008). *

• Pesce JT, Liu Z, Hamed H, Alem F, Whitmire J, Lin H, Liu Q, Urban JF Jr, Gause WC. Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. J. Immunol. 180: 464-474 (2008). *

• Peters IR, Helps CR, Calvert EL, Hall EJ, Day MJ. Cytokine mRNA quantification in histologically normal canine duodenal mucosa by real-time RT-PCR. Vet. Immunol. Immunopathol. 103: 101-111 (2005).

• Peters T, Sindrilaru A, Wang H, Oreshkova T, Renkl AC, Kess D, Scharffetter-Kochanek K. CD18 in monogenic and polygenic inflammatory processes of the skin. J. Investig. Dermatol. Symp. Proc. 11: 7-15 (2006).

• Peterson-Carmichael SL, Harris WT, Goel R, Noah TL, Johnson R, Leigh MW, Davis SD. Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis. Pediatr. Pulmonol. 44: 503-511 (2009).

• Petrausch U, Jensen SM, Twitty C, Poehlein CH, Haley DP, Walker EB, Fox BA. Disruption of TGF-beta signaling prevents the generation of tumor-sensitized regulatory T cells and facilitates therapeutic antitumor immunity. J. Immunol. 183: 3682-3689 (2009).

• Pi L, Oh SH, Shupe T, Petersen BE. Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats. Gastroenterology 128: 2077-2088 (2005). *

• Picard C, Casanova JL. Inherited disorders of cytokines. Curr. Opin. Pediatr. 16: 648-658 (2004).

• Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH. Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J. Immunol. 183: 6124-6134 (2009).

• Pieri L, Domenici L, Romagnoli P. A role for transforming growth factor-beta1 in maintaining the differentiated state of Langerhans cells in human epidermis. Ital. J. Anat. Embryol. 111: 133-149 (2006).

• Pillemer BB, Qi Z, Melgert B, Oriss TB, Ray P, Ray A. STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells. J. Immunol. 183: 155-163 (2009).

• Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC. The epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology Dec 17 [Epub ahead of print] (2009). *

• Pinzani M, Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin. Liver Dis. 21: 397-416 (2001).

• Piquet MA, Gloro R, Justum AM, Reimund JM. Nutritional therapy in inflammatory bowel disease. Gastroenterol. Clin. Biol. 30: 262-271 (2006).

• Pistoia V, Cocco C. IL-21: a new player in the control of isotype switch in Peyer's patches. J. Leukoc. Biol. 85: 739-743 (2009).

• Pittman AM, Naranjo S, Webb E, Broderick P, Lips EH, van Wezel T, Morreau H, Sullivan K, Fielding S, Twiss P, Vijayakrishnan J, Casares F, Qureshi M, Gomez-Skarmeta JL, Houlston RS. The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. Genome Res. 19: 987-993 (2009). *

• Pluchino S, Zanotti L, Brambilla E, Rovere-Querini P, Capobianco A, Alfaro-Cervello C, Salani G, Cossetti C, Borsellino G, Battistini L, Ponzoni M, Doglioni C, Garcia-Verdugo JM, Comi G, Manfredi AA, Martino G. Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One 4: e5959 (2009). *

• Plumb-Rudewiez N, Clotman F, Strick-Marchand H, Pierreux CE, Weiss MC, Rousseau GG, Lemaigre FP. Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology 40: 1266-1274 (2004). *

• Pockros PJ. Antifibrotics for chronic hepatitis C. Clin. Liver Dis. 13: 365-373 (2009).

• Podolsky DK. Lessons from genetic models of inflammatory bowel disease. Acta Gastroenterol. Belg. 60: 163-165 (1997).

• Pohlers D, Beyer A, Koczan D, Wilhelm T, Thiesen HJ, Kinne RW. Constitutive upregulation of the TGF-b pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res. Ther. 9: R59 (2007). *

• Pohlers D, Brenmoehl J, Loffler I, Muller CK, Leipner C, Schultze-Mosgau S, Stallmach A, Kinne RW, Wolf G. TGF-beta and fibrosis in different organs - molecular pathway imprints. Biochim. Biophys. Acta 1792: 746-756 (2009). *

• Polonikov AV, Ivanov VP, Belugin DA, Khoroshaya IV, Kolchanova IO, Solodilova MA, Tutochkina MP, Stepchenko AA. Analysis of common transforming growth factor beta-1 gene polymorphisms in gastric and duodenal ulcer disease: pilot study. J. Gastroenterol. Hepatol. 22: 555-564 (2007). *

• Poncin S, Lengele B, Colin IM, Gerard AC. Differential interactions between Th1/Th2, Th1/Th3, and Th2/Th3 cytokines in the regulation of TPO and DUOX expression, and of thyroglobulin secretion in thyrocytes in vitro. Endocrinology 149: 1534-1542 (2008). *

• Ponnampalam EN, Mann NJ, Sinclair AJ. Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health. Asia Pac. J. Clin. Nutr. 15: 21-29 (2006).

• Pop SM, Wong CP, Culton DA, Clarke SH, Tisch R. Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J. Exp. Med. 201: 1333-1346 (2005). *

• Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R. The type and frequency of immunoregulatory CD4+ T cells govern the efficacy of antigen-specific immunotherapy in diabetic NOD mice. Diabetes 56: 1395-1402 (2007). *

• Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J. Hepatol. 43: 1045-1054 (2005). *

• Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J. Hepatol. 48: 453-464 (2008). *

• Porowski D, Niemczyk M, Ziolkowski J, Mucha K, Foroncewicz B, Nowak M, Pacholczyk M, Chmura A, Paczek L. Intestine as source of cytokines and growth factors. Transplant. Proc. 41: 2989-2991 (2009). *

• Porporatto C, Bianco ID, Correa SG. Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. J. Leukoc. Biol. 78: 62-69 (2005). *

• Potten CS, Owen G, Hewitt D, Chadwick CA, Hendry H, Lord BI, Woolford LB. Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut 36: 864-873 (1995). *

• Powers MP, Nishino H, Luo Y, Raza A, Vanguri A, Rice L, Zu Y, Chang CC. Polymorphisms in TGFbeta and TNFalpha are associated with the myelodysplastic syndrome phenotype. Arch. Pathol. Lab. Med. 131: 1789-1793 (2007).

• Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development 137: 249-259 (2010). *

• Powrie F. Immune regulation in the intestine: a balancing act between effector and regulatory T cell responses. Ann. N. Y. Acad. Sci. 1029: 132-141 (2004). *

• Powrie F, Leach MW. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther. Immunol. 2: 115-123 (1995).

• Powrie F, Read S, Mottet C, Uhlig H, Maloy K. Control of immune pathology by regulatory T cells. Novartis Found. Symp. 252: 92-98 (2003).

• Prandota J. Possible pathomechanism of autoimmune hepatitis. Am. J. Ther. 10: 51-57 (2003).

• Prasad P, Tiwari AK, Prasanna Kumar KM, Ammini AC, Gupta A, Gupta R, Thelma BK. Association of TGFB1, TNFa, CCR2 and CCR5 gene polymorphisms in chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Med. Genet. 8: 20 (2007). *

• Pratap J, Lian JB, Javed A, Barnes GL, van Wijnen AJ, Stein JL, Stein GS. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev. 25: 589-600 (2006). *

• Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, Lendeckel U, Rocken C, Faust J, Neubert K, Schraven B, Martin R, Ansorge S, Brocke S, Reinhold D. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J. Immunol. 178: 4632-4640 (2007). *

• Prelog M, Scheidegger P, Peter S, Gershwin ME, Wick G, Sgonc R. Diminished transforming growth factor 2 production leads to increased expression of a profibrotic procollagen 2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis. Arthritis Rheum. 52: 1804-1811 (2005). *

• Priante G, Musacchio E, Valvason C, Baggio B. EPA and DHA suppress AngII- and arachidonic acid-induced expression of profibrotic genes in human mesangial cells. J. Nephrol. 22: 137-143 (2009).

• Prigione I, Benvenuto F, Bocca P, Battistini L, Uccelli A, Pistoia V. Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T (INKT) cells. Stem Cells 27: 693-702 (2009).

• Prochazkova J, Fric J, Pokorna K, Neuwirth A, Krulova M, Zajicova A, Holan V. Distinct regulatory roles of TGF-beta and IL-4 in development and maintenance of natural and induced CD4+CD25+Foxp3+ regulatory T cells. Immunology 128: e670-e678 (2009).

• Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, Vitolo D, Boirivant M. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm. Bowel Dis. 14: 662-668 (2008). *

• Proux A, Tapiero S, Girszyn N, Levesque H, Marie I. Liver involvement in hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease). Report of one case and review of the literature. Rev. Med. Interne. 28: 775-779 (2007).

• Prud'homme GJ. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 87: 1077-1091 (2007). *

• Prud'homme GJ, Draghia-Akli R, Wang Q. Plasmid-based gene therapy of diabetes mellitus. Gene Ther. 14: 553-564 (2007). *

• Prud'homme GJ, Piccirillo CA. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. J. Autoimmun. 14: 23-42 (2000).

• Pruliere-Escabasse V, Fanen P, Dazy AC, Lechapt-Zalcman E, Rideau D, Edelman A, Escudier E, Coste A. TGFbeta1 downregulates CFTR expression and function in nasal polyps of non-CF patients. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L77-L83 (2005). *

• Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, Cobat A, Ouachee-Chardin M, Toulon A, Bustamante J, Al-Muhsen S, Al-Owain M, Arkwright PD, Costigan C, McConnell V, Cant AJ, Abinun M, Polak M, Bougneres PF, Kumararatne D, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. Feb 1 [Epub ahead of print] (2010). *

• Puig-Kroger A, Corbi A. RUNX3: a new player in myeloid gene expression and immune response. J. Cell. Biochem. 98: 744-756 (2006). *

• Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology 75: 9-21 (2008).

• Pyzik M, Piccirillo CA. The TGF-beta1/Foxp3 regulatory axis in immune self-tolerance: implications for health and disease. Inflamm. Allergy Drug Targets 5: 167-177 (2006).

• Pyzik M, Piccirillo CA. TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets. J. Leukoc. Biol. 82: 335-346 (2007). *

• Qi P, Chen YM, Wang H, Fang M, Ji Q, Zhao YP, Sun XJ, Liu Y, Gao CF. -509C>T polymorphism in the TGF-beta1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection. Cancer Immunol. Immunother. 58: 1433-1440 (2009). *

• Qi P, Ruan CP, Wang H, Zhou FG, Zhao YP, Gu X, Gao CF. -509C>T polymorphism in the TGF-beta1 gene promoter is not associated with susceptibility to and progression of colorectal cancer in Chinese. Colorectal Dis. Oct 22 [Epub ahead of print] (2009). *

• Qian BF, Tonkonogy SL, Sartor RB. Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production. Inflamm. Bowel Dis. 14: 921-930 (2008). *

• Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y. TGF-beta promotes Th17 cell development through inhibition of SOCS3. J. Immunol. 183: 97-105 (2009).

• Queiroz DM, Saraiva IE, Rocha GA, Rocha AM, Gomes LI, Melo FF, Bittencourt PF. IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Microbes Infect. 11: 980-987 (2009). *

• Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS ONE 3: e4026 (2008). *

• Qureshi HY, Ricci G, Zafarullah M. Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes. Biochim. Biophys. Acta 1783: 1605-1612 (2008). *

• Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J. Immunol. 180: 5167-5171 (2008). *

• Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130: 435-452 (2006). *

• Radhakrishnan S, Cabrera R, Schenk EL, Nava-Parada P, Bell MP, Van Keulen VP, Marler RJ, Felts SJ, Pease LR. Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J. Immunol. 181: 3137-3147 (2008). *

• Radom-Aizik S, Leu SY, Cooper DM, Zaldivar F Jr. Serum from exercising humans suppresses T-cell cytokine production. Cytokine 40: 75-81 (2007).

• Radstake TR, van Bon L, Broen J, Hussiani A, Hesselstrand R, Wuttge DM, Deng Y, Simms R, Lubberts E, Lafyatis R. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 4: e5903 (2009). *

• Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, Deng Y, Hussaini A, Simms R, Cruikshank WW, Lafyatis R. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One 4: e5981 (2009). *

• Raetsch C, Jia JD, Boigk G, Bauer M, Hahn EG, Riecken EO, Schuppan D. Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut 50: 241-247 (2002). *

• Rahman S, Gudetta B, Fink J, Granath A, Ashenafi S, Aseffa A, Derbew M, Svensson M, Andersson J, Brighenti SG. Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions. Am. J. Pathol. 174: 2211-2224 (2009). *

• Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J. Steroid Biochem. Mol. Biol. Nov 17 [Epub ahead of print] (2009).

• Ramos-Avila A, Ventura-Gallegos JL, Zentella-Dehesa A, Machuca-Rodriguez C, Moreno-Altamirano MM, Narvaez V, Legorreta-Herrera M. Immunomodulatory role of chloroquine and pyrimethamine in Plasmodium yoelii 17XL infected mice. Scand. J. Immunol. 65: 54-62 (2007). *

• Raqib R, Lindberg AA, Wretlind B, Bardhan PK, Andersson U, Andersson J. Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect. Immun. 63: 289-296 (1995). *

• Raveh E, Cohen S, Levanon D, Groner Y, Gat U. Runx3 is involved in hair shape determination. Dev. Dyn. 233: 1478-1487 (2005). *

• Reding TV, Bimmler DR, Perren A, Sun LK, Fortunato F, Storni F, Graf R. A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model (WBN/Kob rats): significant reduction of macrophage infiltration and fibrosis. Gut 55: 1165-1173 (2006). *

• Redondo S, Hristov M, Gumbel D, Tejerina T, Weber C. Biphasic effect of pioglitazone on isolated human endothelial progenitor cells: involvement of peroxisome proliferator-activated receptor-gamma and transforming growth factor-beta1. Thromb. Haemost. 97: 979-987 (2007).

• Reeves HL, Friedman SL. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front. Biosci. 7: d808-d826 (2002).

• Rehman H, Ramshesh VK, Theruvath TP, Kim I, Currin RT, Giri S, Lemasters JJ, Zhong Z. NIM811, a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J. Pharmacol. Exp. Ther. 327: 699-706 (2008). *

• Reiberger T, Angermayr B, Schwabl P, Rohr-Udilova N, Mitterhauser M, Gangl A, Peck-Radosavljevic M. Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats. J. Hepatol. 51: 865-873 (2009).

• Reibke R, Garbi N, Ganss R, Hammerling GJ, Arnold B, Oelert T. CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen. Proc. Natl. Acad. Sci. U.S.A. 103: 15142-15147 (2006). *

• Reinhold D, Bank U, Tager M, Ansorge S, Wrenger S, Thielitz A, Lendeckel U, Faust J, Neubert K, Brocke S. DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis. Front. Biosci. 13: 2356-2363 (2008).

• Reinhold D, Biton A, Goihl A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Tager M, Ansorge S, Brocke S. Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses. Ann. N. Y. Acad. Sci. 1110: 402-409 (2007). *

• Reinhold D, Biton A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Tager M, Ansorge S, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Int. Immunopharmacol. 6: 1935-1942 (2006).

• Ren Y, Xie Y, Jiang G, Fan J, Yeung J, Li W, Tam PK, Savill J. Apoptotic cells protect mice against lipopolysaccharide-induced shock. J. Immunol. 180: 4978-4985 (2008). *

• Resendiz-Albor AA, Reina-Garfias H, Rojas-Hernandez S, Jarillo-Luna A, Rivera-Aguilar V, Miliar-García A, Campos-Rodríguez R. Regionalization of pIgR expression in the mucosa of mouse small intestine. Immunol. Lett. Nov 16 [Epub ahead of print] (2009).

• Rezaei N, Aghamohammadi A, Shakiba Y, Mahmoudi M, Jalali A, Moradi B, Amirzargar AA. Cytokine gene polymorphisms in common variable immunodeficiency. Int. Arch. Allergy Immunol. 150: 1-7 (2009).

• Rezaie A, Ghorbani F, Eshghtork A, Zamani MJ, Dehghan G, Taghavi B, Nikfar S, Mohammadirad A, Daryani NE, Abdollahi M. Alterations in salivary antioxidants, nitric oxide, and transforming growth factor-beta1 in relation to disease activity in Crohn's disease patients. Ann. N. Y. Acad. Sci. 1091: 110-122 (2006). *

• Rezaie A, Khalaj S, Shabihkhani M, Nikfar S, Zamani MJ, Mohammadirad A, Daryani NE, Abdollahi M. Study on the correlations among disease activity index and salivary transforming growth factor-beta1 and nitric oxide in ulcerative colitis patients. Ann. N. Y. Acad. Sci. 1095: 305-314 (2007). *

• Rhee CK, Lee SY, Kang JY, Kim SJ, Kwon SS, Kim YK, Park SH. Effect of peroxisome proliferator-sctivated receptor-gamma on airway smooth muscle thickening in a murine model of chronic asthma. Int. Arch. Allergy Immunol. 148: 289-296 (2009).

• Ribeiro CS, Visentainer JE, Moliterno RA. Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients. Mem. Inst. Oswaldo Cruz. 102: 435-440 (2007). *

• RiBmann A, Pieper S, Adams I, Brune T, Wiemann D, Reinhold D. Increased blood plasma concentrations of TGF-beta1 and TGF-beta2 after treatment with intravenous immunoglobulins in childhood autoimmune diseases. Pediatr. Allergy Immunol. 20: 261-265 (2009).

• Richer MJ, Fang D, Shanina I, Horwitz MS. Toll-like receptor 4-induced cytokine production circumvents protection conferred by TGF-beta in coxsackievirus-mediated autoimmune myocarditis. Clin. Immunol. 121: 339-349 (2006). *

• Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr. Opin. Gastroenterol. 24: 462-468 (2008). *

• Rifas L. T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization. J. Cell. Biochem. 98: 706-714 (2006). *

• Rifas L, Arackal S. T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism. Arthritis Rheum. 48: 993-1001 (2003). *

• Risques RA, Rabinovitch PS, Brentnall TA. Cancer surveillance in inflammatory bowel disease: new molecular approaches. Curr. Opin. Gastroenterol. 22: 382-390 (2006).

• Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 47: 571-579 (2007). *

• Rivera TL, Izmirly PM, Birnbaum BK, Byrne P, Brauth JB, Katholi M, Kim MY, Fischer J, Clancy RM, Buyon JP. Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus. Ann. Rheum. Dis. 68: 828-835 (2009).

• Robert K, Nehme J, Bourdon E, Pivert G, Friguet B, Delcayre C, Delabar JM, Janel N. Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 128: 1405-1415 (2005). *

• Roberts AB, Piek E, Bottinger EP, Ashcroft G, Mitchell JB, Flanders KC. Is Smad3 a major player in signal transduction pathways leading to fibrogenesis? Chest 120: 43S-47S (2001). *

• Roberts AB, Russo A, Felici A, Flanders KC. Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann. N. Y. Acad. Sci. 995: 1-10 (2003). *

• Roberts T, Beyers N, Aguirre A, Walzl G. Immunosuppression during active tuberculosis is characterized by decreased interferon-gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels. J. Infect. Dis. 195: 870-878 (2007). *

• Robertson H, Kirby JA, Yip WW, Jones DE, Burt AD. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology 45: 977-981 (2007). *

• Robinson RT, Gorham JD. TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the periphery. J. Immunol. 179: 71-79 (2007). *

• Robinson RT, Wang J, Cripps JG, Milks MW, English KA, Pearson TA, Gorham JD. End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas. J. Immunol. 182: 3278-3284 (2009).

• Rodan GA, Noda M. Gene expression in osteoblastic cells. Crit. Rev. Eukaryot. Gene Expr. 1: 85-98 (1991).

• Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J. Clin. Invest. 101: 2790-2799 (1998). *

• Rogler CE, Levoci L, Ader T, Massimi A, Tchaikovskaya T, Norel R, Rogler LE. MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology 50: 575-584 (2009).

• Rogler G, Andus T. Cytokines in inflammatory bowel disease. World J. Surg. 22: 382-389 (1998). *

• Romagnani S. Human Th17 cells. Arthritis Res. Ther. 10: 206 (2008). *

• Romagnani S. Regulation of the T cell response. Clin. Exp. Allergy 36: 1357-1366 (2006). *

• Romagnani S, Maggi E, Liotta F, Cosmi L, Annunziato F. Properties and origin of human Th17 cells. Mol. Immunol. 47: 3-7 (2009). *

• Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. Osteoarthritis Cartilage 15: 1367-1377 (2007).

• Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212: 28-50 (2006). *

• Rondelli FM, Mahuad CV, Gentiletti A, Goni M, Pons-Estel B, Bottasso O, Stanford JL, Bay ML. Altered production of IFN-gamma and other inflammation-related cytokines by mycobacteria-stimulated peripheral blood mononuclear cells from rheumatoid arthritis patients. Cell. Mol. Biol. (Noisy-le-grand) 52: 59-64 (2006).

• Ronger-Savle S, Valladeau J, Claudy A, Schmitt D, Peguet-Navarro J, Dezutter-Dambuyant C, Thomas L, Jullien D. TGFbeta inhibits CD1d expression on dendritic cells. J. Invest. Dermatol. 124: 116-118 (2005). *

• Rook GAW. Microecology, hygiene and mucosal immunology. Falk Symposium 140. Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice. Dubrovnik (Croatia). p. 33. May 7-8 (2004). *

• Rosa JS, Oliver SR, Flores RL, Graf SC, Pontello AM, Lbardolaza M, Zaldivar FP, Galassetti PR. Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. J. Pediatr. Endocrinol. Metab. 20: 1293-1305 (2007).

• Rosignoli F, Torroba M, Juarranz Y, Garcia-Gomez M, Martinez C, Gomariz RP, Perez-Leiros C, Leceta J. VIP and tolerance induction in autoimmunity. Ann. N. Y. Acad. Sci. 1070: 525-530 (2006). *

• Rossi G, Nigro G, Tattoli I, Vincenzetti S, Mariani P, Magi GE, Renzoni G, Taccini E, Bernardini ML. Adhesion molecules and cytokine profile in ileal tissue of sheep infected with Mycobacterium avium subsp. paratuberculosis. Microbes Infect. 11: 698-706 (2009). *

• Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. TGF-beta1 inhibits CFTR-dependent cAMP-stimulated alveolar epithelial fluid transport via a PI3K-dependent mechanism. J. Biol. Chem. Dec 8 [Epub ahead of print] (2009). *

• Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles C, Rampton DS, Corazza GR, Monteleone G, Di Sabatino A, MacDonald TT. Differential regulation of interleukin-17 and interferon-gamma production in inflammatory bowel disease. Gut 58: 1629-1636 (2009). *

• Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. J. Immunol. 181: 4485-4494 (2008). *

• Rubtsov YP, Rudensky AY. TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat. Rev. Immunol. 7: 443-453 (2007). *

• Ruby CE, Yates MA, Hirschhorn-Cymerman D, Chlebeck P, Wolchok JD, Houghton AN, Offner H, Weinberg AD. Cutting edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J. Immunol. 183: 4853-4857 (2009).

• Ruddell RG, Knight B, Tirnitz-Parker JE, Akhurst B, Summerville L, Subramaniam VN, Olynyk JK, Ramm GA. Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology 49: 227-239 (2009). *

• Rueda B, Simeon C, Hesselstrand R, Herrick A, Worthington J, Ortego-Centeno N, Riemekasten G, Fonollosa V, Vonk MC, van den Hoogen FH, Sanchez-Román J, Aguirre-Zamorano MA, García-Portales R, Pros A, Camps MT, Gonzalez-Gay MA, Coenen MJ, Lambert N, et al. A large multicenter analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype. Ann. Rheum. Dis. 68: 1618-1620 (2009).

• Ruffolo C, Scarpa M, Faggian D, Basso D, D'Inca R, Plebani M, Sturniolo GC, Bassi N, Angriman I. Subclinical intestinal inflammation in patients with Crohn's disease following bowel resection: a smoldering fire. J. Gastrointest. Surg. Nov 10 [Epub ahead of print] (2009). *

• Ruffolo C, Scarpa M, Faggian D, Pozza A, Navaglia F, D'Inca R, Hoxha P, Romanato G, Polese L, Sturniolo GC, Plebani M, D'Amico DF, Angriman I. Cytokine network in rectal mucosa in perianal Crohn's disease: relations with inflammatory parameters and need for surgery. Inflamm. Bowel Dis. 14: 1406-1412 (2008). *

• Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation. Ann. N. Y. Acad. Sci. 1072: 389-394 (2006). *

• Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J. Immunol. 174: 2990-2999 (2005). *

• Ruster C, Wolf G. Renin-angiotensin-aldosterone system and progression of renal disease. J. Am. Soc. Nephrol. 17: 2985-2991 (2006). *

• Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108: 1435-1440 (2006). *

• Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG. Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice. Inflamm. Bowel Dis. 15: 491-500 (2009).

• Ryan JJ, Kashyap M, Bailey D, Kennedy S, Speiran K, Brenzovich J, Barnstein B, Oskeritzian C, Gomez G. Mast cell homeostasis: a fundamental aspect of allergic disease. Crit. Rev. Immunol. 27: 15-32 (2007).

• Ryan KR, Hong M, Arkwright PD, Gennery AR, Costigan C, Dominguez M, Denning D, McConnell V, Cant AJ, Abinun M, Spickett GP, Lilic D. Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. Clin. Exp. Immunol. 154: 406-414 (2008). *

• Ryden A, Stechova K, Durilova M, Faresjo M. Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes. Diabetes Metab. Res. Rev. 25: 335-343 (2009).

• Rynda A, Maddaloni M, Mierzejewska D, Ochoa-Reparaz J, Maslanka T, Crist K, Riccardi C, Barszczewska B, Fujihashi K, McGhee JR, Pascual DW. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein {sigma}1. J. Immunol. 180: 5187-5200 (2008). *

• Rynda A, Maddaloni M, Ochoa-Reparaz J, Callis G, Pascual DW. IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE). PLoS One 5: e8720 (2010). *

• Ryu SH, Chung YH, Lee JK, Kim JA, Shin JW, Jang MK, Park NH, Lee HC, Lee YS, Suh DJ. Antifibrogenic effects of tamoxifen in a rat model of periportal hepatic fibrosis. Liver Int. 29: 308-314 (2009). *

• Sa EH, Jin UH, Kim DS, Kang BS, Ha KT, Kim JK, Park WH, Kim CH. Herbal medicine Gamgungtang down-regulates autoimmunity through induction of TH2 cytokine production by lymphocytes in experimental thyroiditis model. J. Ethnopharmacol. 109: 472-479 (2007). *

• Sa-nguanmoo P, Vejchapipat P, Chongsrisawat V, Chirathaworn C, Honsawek S, Theamboonlers A, Poovorawan Y. Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. J. Med. Assoc. Thai. 90: 251-257 (2007).

• Sacks S. Complement fragments C3a and C5a: the salt and pepper of the immune response. Eur. J. Immunol. Feb 22 [Epub ahead of print] (2010).

• Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G. Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation 88: 1109-1116 (2009).

• Saeki C, Nakano M, Takahashi H, Saito S, Homma S, Tajiri H, Zeniya M. Accumulation of functional regulatory T cells in actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation. Clin. Immunol. Jan 14 [Epub ahead of print] (2010). *

• Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, Friedman SL. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 127: 870-882 (2004). *

• Saika S, Yamanaka O, Okada Y, Miyamoto T, Kitano A, Flanders KC, Ohnishi Y, Nakajima Y, Kao WW, Ikeda K. Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Am. J. Physiol. Cell Physiol. 293: C75-C86 (2007). *

• Saito H, Tsurikisawa N, Tsuburai T, Akiyama K. Involvement of regulatory T cells in the pathogenesis of Churg-Strauss syndrome. Int. Arch. Allergy Immunol. 146 Suppl. 1: 73-76 (2008).

• Saito H, Tsurikisawa N, Tsuburai T, Oshikata C, Akiyama K. Cytokine production profile of CD4+ T cells from patients with active Churg-Strauss syndrome tends toward Th17. Int. Arch. Allergy Immunol. 149 Suppl. 1: 61-65 (2009).

• Sakaguchi K, Kitano M, Nishimura M, Senoh T, Ohta T, Terao M, Shinji N, Koide N, Tsuji T. Serum level of transforming growth factor-beta1 (TGF-beta1) and the expression of TGF-beta receptor type II in peripheral blood mononuclear cells in patients with autoimmune hepatitis. Hepatogastroenterology 51: 1780-1783 (2004).

• Sakata M, Yasuda H, Moriyama H, Yamada K, Kotani R, Kurohara M, Okumachi Y, Kishi M, Arai T, Hara K, Hamada H, Yokono K, Nagata M. Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules. Diabetes Res. Clin. Pract. 80: 352-359 (2008).

• Sakimura K, Matsumoto T, Miyamoto C, Osaki M, Shindo H. Effects of insulin-like growth factor I on transforming growth factor beta(1) induced chondrogenesis of synovium-derived mesenchymal stem cells cultured in a polyglycolic acid scaffold. Cells Tissues Organs 183: 55-61 (2006).

• Sakkas LI, Chikanza IC, Platsoucas CD. Mechanisms of disease: the role of immune cells in the pathogenesis of systemic sclerosis. Nat. Clin. Pract. Rheumatol. 2: 679-685 (2006). *

• Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A. TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int. Immunol. 19: 117-126 (2007). *

• Salam MT, Gauderman WJ, McConnell R, Lin PC, Gilliland FD. Transforming growth factor-beta1 C-509T polymorphism, oxidant stress, and early onset childhood asthma. Am. J. Respir. Crit. Care Med. 176: 1192-1199 (2007). *

• Salbert G, Fanjul A, Piedrafita FJ, Lu XP, Kim SJ, Tran P, Pfahl M. Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity. Mol. Endocrinol. 7: 1347-1356 (1993). *

• Salguero Palacios R, Roderfeld M, Hemmann S, Rath T, Atanasova S, Tschuschner A, Gressner OA, Weiskirchen R, Graf J, Roeb E. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab. Invest. 88: 1192-1203 (2008). *

• Salib RJ. Transforming growth factor-beta gene expression studies in nasal mucosal biopsies in naturally occurring allergic rhinitis. Ann. R. Coll. Surg. Engl. 89: 563-573 (2007).

• Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 112: 1813-1821 (2008). *

• Sampsonas F, Karkoulias K, Kaparianos A, Spiropoulos K. Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency. Curr. Med. Chem. 13: 2857-2873 (2006).

• Samuel G, Maier LA. Immunology of chronic beryllium disease. Curr. Opin. Allergy Clin. Immunol. 8: 126-134 (2008).

• Sanchez AP, Sharma K. Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev. Mol. Med. 11: e13 (2009).

• Sanjabi S, Mosaheb MM, Flavell RA. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity 31: 131-144 (2009). *

• Santarlasci V, Maggi L, Capone M, Frosali F, Querci V, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F. TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur. J. Immunol. 39: 207-215 (2009). *

• Santiago B, Gutierrez-Canas I, Dotor J, Palao G, Lasarte JJ, Ruiz J, Prieto J, Borras-Cuesta F, Pablos JL. Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis. J. Invest. Dermatol. 125: 450-455 (2005). *

• Santiago OI, Rivera E, Ferder L, Appleyard CB. An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis. Regul. Pept. 146: 250-259 (2008).

• Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, Nanan R. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J. Immunol. 183: 7023-7030 (2009). *

• Santodomingo-Garzon T, Han J, Le T, Yang Y, Swain MG. Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology 49: 1267-1276 (2009).

• Santucci L, Wallace J, Mencarelli A, Farneti S, Morelli A, Fiorucci S. Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis. Gastroenterology 128: 1243-1257 (2005). *

• Sartor RB. Immunomodulatory properties of the gut microflora. Falk Symposium 146: GUT-LIVER INTERACTIONS: BASIC AND CLINICAL CONCEPTS, Innsbruck (Austria), March 11-12, 2005, p. 44 (2005). *

• Saruta M, Yu QT, Fleshner PR, Mantel PY, Schmidt-Weber CB, Banham AH, Papadakis KA. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin. Immunol. 125: 281-290 (2007). *

• Sasaki K, Iizuka M, Konno S, Shindo K, Sato A, Horie Y, Watanabe S. Ecabet sodium prevents the delay of wound repair in intestinal epithelial cells induced by hydrogen peroxide. J. Gastroenterol. 40: 474-482 (2005). *

• Sasaki M, Ikeda H, Sawada S, Sato Y, Nakanuma Y. Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis. J. Clin. Pathol. 60: 1102-1107 (2007).

• Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6: 1087-1095 (2005). *

• Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int. Immunol. 18: 1405-1411 (2006). *

• Satoguina JS, Adjobimey T, Arndts K, Hoch J, Oldenburg J, Layland LE, Hoerauf A. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. Eur. J. Immunol. 38: 3101-3113 (2008). *

• Satoh Y, Ishiguro Y, Sakuraba H, Kawaguchi S, Hiraga H, Fukuda S, Nakane A. Cyclosporine regulates intestinal epithelial apoptosis via TGF-beta related signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G514-G519 (2009). *

• Satsangi J, Campbell H, Dunlop MG, Porteous ME. Molecular genetics in gastroenterology: from research success to clinical application? Nat. Clin. Pract. Gastroenterol. Hepatol. 2: 118-119 (2005). *

• Saurer L, McCullough KC, Summerfield A. In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid. J. Immunol. 179: 3504-3514 (2007). *

• Sauter SN, Benyacoub J, Allenspach K, Gaschen F, Ontsouka E, Reuteler G, Cavadini C, Knorr R, Blum JW. Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet. J. Anim. Physiol. Anim. Nutr. (Berl.) 90: 269-277 (2006). *

• Savage ND, de Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH. Human anti-inflammatory macrophages induce Foxp3+GITR+CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J. Immunol. 181: 2220-2226 (2008). *

• Saxena V, Lienesch DW, Zhou M, Bommireddy R, Azhar M, Doetschman T, Singh RR. Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. J. Immunol. 180: 1903-1912 (2008). *

• Scarpa M, Bortolami M, Morgan SL, Kotsafti A, Ruffolo C, D'Inca R, Bertin E, Polese L, D'Amico DF, Sturniolo GC, Angriman I. TGF-beta1 and IGF-1 and anastomotic recurrence of Crohn's disease after ileo-colonic resection. J. Gastrointest. Surg. 12: 1981-1990 (2008). *

• Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B. A skin-selective homing mechanism for human immune surveillance T cells. J. Exp. Med. 199: 1265-1275 (2004). *

• Schambach F, Schupp M, Lazar MA, Reiner SL. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur. J. Immunol. 37: 2396-2399 (2007). *

• Schauber J, Buchau AS, Gallo RL. 1,25-Dihydroxy vitamin D3 regulates cutaneous innate immune function. Exp. Dermatol. 17: 629-630 (2008).

• Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zugel U, Bikle DD, Modlin RL, Gallo RL. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J. Clin. Invest. 117: 803-811 (2007). *

• Schena FP, Cerullo G, Torres DD, Scolari F, Foramitti M, Amoroso A, Pirulli D, Floege J, Mertens PR, Zerres K, Alexopoulos E, Kirmizis D, Zelante L, Bisceglia L. Role of interferon-gamma gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study. Eur. J. Hum. Genet. 14: 488-496 (2006). *

• Schiffrin EJ, Yousfi ME, Faure M, Combaret L, Donnet A, Blum S, Obled C, Breuille D. Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model. JPEN J. Parenter. Enteral Nutr. 29: S141-S150 (2005). *

• Schmitt E, Hoehn P, Huels C, Goedert S, Palm N, Rude E, Germann T. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta. Eur. J. Immunol. 24: 793-798 (1994).

• Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis. Pancreatology 4: 490-494 (2004).

• Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M. Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. PLoS. Pathog. 5: e1000543 (2009). *

• Schotte H, Willeke P, Rust S, Assmann G, Domschke W, Gaubitz M, Schluter B. The transforming growth factor-beta1 gene polymorphism (G915C) is not associated with systemic lupus erythematosus. Lupus 12: 86-92 (2003).

• Schramm C, Huber S, Protschka M, Czochra P, Burg J, Schmitt E, Lohse AW, Galle PR, Blessing M. TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int. Immunol. 16: 1241-1249 (2004). *

• Schreiber TH, Deyev VV, Rosenblatt JD, Podack ER. Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination. Cancer Res. 69: 2026-2033 (2009). *

• Schrijver HM, Crusius JB, Garcia-Gonzalez MA, Polman CH, Pena AS, Barkhof F, Uitdehaag BM. Gender-related association between the TGFB1+869 polymorphism and multiple sclerosis. J. Interferon Cytokine Res. 24: 536-542 (2004).

• Schulmann K, Mori Y, Croog V, Yin J, Olaru A, Sterian A, Sato F, Wang S, Xu Y, Deacu E, Berki AT, Hamilton JP, Kan T, Abraham JM, Schmiegel W, Harpaz N, Meltzer SJ. Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability. Gastroenterology 129: 74-85 (2005). *

• Schulte CM, Goebell H, Roher HD, Schulte KM. C-509T polymorphism in the TGFB1 gene promoter: impact on Crohn's disease susceptibility and clinical course? Immunogenetics 53: 178-182 (2001).

• Schumacher JA, Crockett DK, Elenitoba-Johnson KS, Lim MS. Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells. Proteomics 7: 2603-2616 (2007). *

• Schuppan D. How should and how does antifibrotic therapy act in biliary liver diseases? Falk Symposium 136. XII FALK LIVER WEEK 2003 (Part I) In Honour of Hans Popper’s 100th Birthday. Cholestatic Liver Diseases: Therapeutical Options and Perspectives. Freiburg (Germany). p. 85. October 15-16 (2003). *

• Schuppan D, Jia JD, Brinkhaus B, Hahn EG. Herbal products for liver diseases: a therapeutic challenge for the new millennium. Hepatology 30: 1099-1104 (1999). *

• Schurks M, Kurth T, Buring JE, Zee RY. A candidate gene association study of 77 polymorphisms in migraine. J. Pain 10: 759-766 (2009).

• Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J. Exp. Med. 206: 169-181 (2009). *

• Schwarz KB, Rosensweig J, Sharma S, Jones L, Durant M, Potter C, Narkewicz MR. Plasma markers of platelet activation in cystic fibrosis liver and lung disease. J. Pediatr. Gastroenterol. Nutr. 37: 187-191 (2003). *

• Scola L, Vaglica M, Crivello A, Palmeri L, Forte GI, Macaluso MC, Giacalone A, Noto LD, Bongiovanni A, Raimondi C, Accardo A, Verna R, Candore G, Caruso C, Lio D, Palmeri S. Cytokine gene polymorphisms and breast cancer susceptibility. Ann. N. Y. Acad. Sci. 1089: 104-109 (2006). *

• Scott FW, Rowsell P, Wang GS, Burghardt K, Kolb H, Flohe S. Oral exposure to diabetes-promoting food or immunomodulators in neonates alters gut cytokines and diabetes. Diabetes 51: 73-78 (2002). *

• Scutera S, Riboldi E, Daniele R, Elia AR, Fraone T, Castagnoli C, Giovarelli M, Musso T, Sozzani S. Production and function of activin A in human dendritic cells. Eur. Cytokine Netw. 19: 67-75 (2008).

• Seddon B, Mason D. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes. J. Exp. Med. 189: 279-288 (1999). *

• Sedlaczek N, Jia JD, Bauer M, Herbst H, Ruehl M, Hahn EG, Schuppan D. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am. J. Pathol. 158: 1239-1244 (2001). *

• Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol. Biol. Cell 19: 1261-1270 (2008). *

• Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat. Med. 13: 1324-1332 (2007). *

• Seki N, Hashimoto N, Suzuki Y, Yagui K, Saito Y. Differential effects of RAS inhibitors associated with ACE gene polymorphisms in type 2 diabetic nephropathy. Diabetes Res. Clin. Pract. 72: 135-141 (2006).

• Sela M. Immunomodulatory vaccines against autoimmune diseases. Rejuvenation Res. 9: 126-133 (2006).

• Sela M, Mozes E. Therapeutic vaccines in autoimmunity. Proc. Natl. Acad. Sci. U.S.A. 101: 14586-14592 (2004). *

• Sela U, Dayan M, Hershkoviz R, Cahalon L, Lider O, Mozes E. The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur. J. Immunol. 36: 2971-2980 (2006). *

• Sela U, Sharabi A, Dayan M, Hershkoviz R, Mozes E. The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models. Immunology 128: e395-e405 (2009). *

• Sellebjerg F, Bornsen L, Khademi M, Krakauer M, Olsson T, Frederiksen JL, Sorensen PS. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 73: 2003-2010 (2009).

• Selmi C, Zuin M, Gershwin ME. The unfinished business of primary biliary cirrhosis. J. Hepatol. 49: 451-460 (2008). *

• Selvam R, Maheswari P, Kavitha P, Ravichandran M, Sas B, Ramchand CN. Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease. Indian J. Biochem. Biophys. 46: 79-85 (2009).

• Selvaraj RK, Geiger TL. Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J. Immunol. 180: 2830-2838 (2008). *

• Semitekolou M, Alissafi T, Aggelakopoulou M, Kourepini E, Kariyawasam HH, Kay AB, Robinson DS, Lloyd CM, Panoutsakopoulou V, Xanthou G. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J. Exp. Med. 206: 1769-1785 (2009). *

• Sengupta U, Ukil S, Dimitrova N, Agrawal S. Expression-based network biology identifies alteration in key regulatory pathways of type 2 diabetes and associated risk/complications. PLoS One 4: e8100 (2009). *

• Seo GY, Youn J, Kim PH. IL-21 ensures TGF-beta 1-induced IgA isotype expression in mouse Peyer's patches. J. Leukoc. Biol. 85: 744-750 (2009).

• Sepulveda-Flores RN, Vera-Cabrera L, Flores-Gutierrez JP, Maldonado-Garza H, Salinas-Garza R, Zorrilla-Blanco P, Bosques-Padilla FJ. Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. Ann. Hepatol. 1: 36-39 (2002). *

• Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6: 1191-1197 (2005). *

• Serlin DM, Kuang PP, Subramanian M, O'Regan A, Li X, Berman JS, Goldstein RH. Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts. J. Cell. Biochem. 97: 519-529 (2006). *

• Seyhan H, Hamzavi J, Wiercinska E, Gressner AM, Mertens PR, Kopp J, Horch RE, Breitkopf K, Dooley S. Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling. J. Cell. Mol. Med. 10: 922-932 (2006). *

• Sfikakis PP, Souliotis VL, Fragiadaki KG, Moutsopoulos HM, Boletis JN, Theofilopoulos AN. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin. Immunol. 123: 66-73 (2007). *

• Shackel NA, McCaughan GW, Warner FJ. Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling. Hepatology 47: 2134-2136 (2008). *

• Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut 49: 565-576 (2001). *

• Shafer-Weaver KA, Anderson MJ, Stagliano K, Malyguine A, Greenberg NM, Hurwitz AA. Cutting edge: tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells. J. Immunol. 183: 4848-4852 (2009).

• Shah S, Qiao L. Resting B cells expand a CD4(+)CD25(+)Foxp3(+) Treg population via TGF-beta3. Eur. J. Immunol. 38: 2488-2498 (2008). *

• Shainheit MG, Smith PM, Bazzone LE, Wang AC, Rutitzky LI, Stadecker MJ. Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology. J. Immunol. 181: 8559-8567 (2008). *

• Shale M, Kaplan GG, Panaccione R, Ghosh S. Isotretinoin and intestinal inflammation: what gastroenterologists need to know. Gut 58: 737-741 (2009). *

• Shao XS, Yang XQ, Zhao XD, Li Q, Xie YY, Wang XG, Wang M, Zhang W. The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome. Pediatr. Nephrol. 24: 1683-1690 (2009).

• Sharabi A, Azulai H, Sthoeger ZM, Mozes E. Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action. Immunology 121: 248-257 (2007). *

• Sharabi A, Lapter S, Mozes E. Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide. J. Autoimmun. Jul 11 [Epub ahead of print] (2009).

• Sharabi A, Mozes E. The suppression of murine lupus by a tolerogenic peptide involves Foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J. Immunol. 181: 3243-3251 (2008). *

• Sharabi A, Zinger H, Zborowsky M, Sthoeger ZM, Mozes E. A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta. Proc. Natl. Acad. Sci. U.S.A. 103: 8810-8815 (2006). *

• Sharma A, Belna J, Espat J, Rodriguez G, Cannon VT, Hurteau JA. Effects of omega-3 fatty acids on components of the transforming growth factor beta-1 pathway: implication for dietary modification and prevention in ovarian cancer. Am. J. Obstet. Gynecol. 200: 516.e1-e6 (2009).

• Sharp R, Babyatsky MW, Takagi H, Tagerud S, Wang TC, Bockman DE, Brand SJ, Merlino G. Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice. Development 121: 149-161 (1995). *

• She D, Li Y, Zhang H, Graubard BI, Li Z. Trend tests for genetic association using population-based cross-sectional complex survey data. Biostatistics 11: 48-56 (2010).

• She D, Zhang H, Li Z. Testing Hardy-Weinberg equilibrium using family data from complex surveys. Ann. Hum. Genet. 73: 449-455 (2009). *

• Sheil B, MacSharry J, O'Callaghan L, O'Riordan A, Waters A, Morgan J, Collins JK, O'Mahony L, Shanahan F. Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice. Clin. Exp. Immunol. 144: 273-280 (2006). *

• Sheil B, McCarthy J, O'Mahony L, Bennett MW, Ryan P, Fitzgibbon JJ, Kiely B, Collins JK, Shanahan F. Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut 53: 694-700 (2004). *

• Shek FW, Benyon RC. How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur. J. Gastroenterol. Hepatol. 16: 123-126 (2004).

• Shen L, Smith JM, Shen Z, Eriksson M, Sentman C, Wira CR. Inhibition of human neutrophil degranulation by transforming growth factor-beta1. Clin. Exp. Immunol. 149: 155-161 (2007). *

• Shen Z, Chen L, Hao F, Wu J. Transcriptional regulation of Foxp3 gene: multiple signal pathways on the road. Med. Res. Rev. 29: 742-766 (2009).

• Shen Z, Chen L, Liu YF, Gao TW, Wang G, Fan XL, Fan JY, Fan PS, Li CY, Liu B, Dang YP, Li CX. Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. J. Am. Acad. Dermatol. 54: 992-1002 (2006).

• Sherer Y, Zinger H, Shoenfeld Y. Atherosclerosis in systemic lupus erythematosus. Autoimmunity Dec 17 [Epub ahead of print] (2009).

• Shevach EM, Davidson TS, Huter EN, Dipaolo RA, Andersson J. Role of TGF-beta in the Induction of Foxp3 expression and T regulatory cell function. J. Clin. Immunol. 28: 640-646 (2008). *

• Shi J, Fan Y, Xu R, Zuo K, Cheng L, Xu G, Li H. Characterizing T-cell phenotypes in nasal polyposis in Chinese patients. J. Investig. Allergol. Clin. Immunol. 19: 276-282 (2009). *

• Shi W, Bellusci S, Warburton D. Lung development and adult lung diseases. Chest 132: 651-656 (2007). *

• Shi X, Bai S, Li L, Cao X. Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. J. Biol. Chem. 276: 850-855 (2001). *

• Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc. Natl. Acad. Sci. U.S.A. 107: 2189-2194 (2010). *

• Shimamura M, Huang YY, Kobayashi M, Goji H. Altered production of immunoregulatory cytokines by invariant Valpha19 TCR-bearing cells dependent on the duration and intensity of TCR engagement. Int. Immunol. 21: 179-185 (2009).

• Shimizu K. Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis. J. Gastroenterol. 43: 823-832 (2008). *

• Shimizu K, Kobayashi M, Tahara J, Shiratori K. Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology 128: 2105-2118 (2005). *

• Shimojo N, Jesmin S, Zaedi S, Maeda S, Soma M, Aonuma K, Yamaguchi I, Miyauchi T. Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-beta1 and phosphorylated JNK. Am. J. Physiol. Heart Circ. Physiol. 291: H835-H845 (2006). *

• Shin S, Moon S, Park Y, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim K. Role of cordycepin and adenosine on the phenotypic switch of macrophages via induced anti-inflammatory cytokines. Immune Netw. 9: 255-264 (2009).

• Shindo K, Iizuka M, Sasaki K, Konno S, Itou H, Horie Y, Watanabe S. Sucralfate prevents the delay of wound repair in intestinal epithelial cells by hydrogen peroxide through NF-kappaB pathway. J. Gastroenterol. 41: 450-461 (2006). *

• Shirahige A, Mizushima T, Matsushita K, Sawa K, Ochi K, Ichimura M, Tanioka H, Shinji T, Koide N, Tanimoto M. Oral administration of taurine improves experimental pancreatic fibrosis. J. Gastroenterol. Hepatol. 23: 321-327 (2008). *

• Shu JC, Wang HL, Ye GR, He YJ, Lu X, Fang L. The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine. Zhong Yao Cai 30: 1421-1425 (2007).

• Siddiqui KR, Powrie F. CD103+ GALT DCs promote Foxp3+ regulatory T cells. Mucosal Immunol. 1 Suppl. 1: S34-S38 (2008).

• Sidell N, Feng Y, Hao L, Wu J, Yu J, Kane MA, Napoli JL, Taylor RN. Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells. Mol. Endocrinol. 24: 148-160 (2010). *

• Sie MP, Uitterlinden AG, Bos MJ, Arp PP, Breteler MM, Koudstaal PJ, Pols HA, Hofman A, van Duijn CM, Witteman JC. TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke. The Rotterdam study. Stroke 37: 2667-2671 (2006).

• Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol. 21: 555-565 (2009).

• Sigal LH. Basic science for the clinician 48: tyrosine kinases in disease: the potential for inhibitors in the treatment of immunologic diseases. J. Clin. Rheumatol. 14: 45-48 (2008).

• Siglienti I, Chan A, Kleinschnitz C, Jander S, Toyka KV, Gold R, Stoll G. Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions. J. Neuropathol. Exp. Neurol. 66: 47-56 (2007).

• Siller-Lopez F, Sandoval A, Salgado S, Salazar A, Bueno M, Garcia J, Vera J, Galvez J, Hernandez I, Ramos M, Aguilar-Cordova E, Armendariz-Borunda J. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology 126: 1122-1133 (2004). *

• Silva HM, Vieira PM, Costa PL, Pimentel BM, Moro AM, Kalil J, Maranhao AQ, Coelho V, Brigido MM. Novel humanized anti-CD3 antibodies induce a predominantly immunoregulatory profile in human peripheral blood mononuclear cells. Immunol. Lett. 125: 129-136 (2009).

• Silver PB, Agarwal RK, Su SB, Suffia I, Grajewski RS, Luger D, Chan CC, Mahdi RM, Nickerson JM, Caspi RR. Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J. Immunol. 179: 5146-5158 (2007). *

• Sime PJ. The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis. J. Investig. Med. 56: 534-538 (2008).

• Simka M. Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis. Curr. Neurovasc. Res. 6: 132-139 (2009).

• Singh B, Murphy RF, Ding XZ, Roginsky AB, Bell RH Jr, Adrian TE. On the role of transforming growth factor-beta in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells. Mol. Cancer 6: 82 (2007). *

• Singh H, Jain M, Mittal B. Role of TGF-beta1 (-509C>T) promoter polymorphism in susceptibility to cervical cancer. Oncol. Res. 18: 41-45 (2009).

• Singh R, Aggarwal A, Misra R. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J. Rheumatol. 34: 2285-2290 (2007). *

• Singh RP, La Cava A, Wong M, Ebling F, Hahn BH. CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J. Immunol. 178: 7649-7657 (2007). *

• Sinha S, Kaler LJ, Proctor TM, Teuscher C, Vandenbark AA, Offner H. IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis. J. Immunol. 180: 2679-2685 (2008). *

• Sirica AE. Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology 41: 5-15 (2005). *

• Sivalingam SP, Thumboo J, Vasoo S, Thio ST, Tse C, Fong KY. In vivo pro- and anti-inflammatory cytokines in normal and patients with rheumatoid arthritis. Ann. Acad. Med. Singapore 36: 96-964 (2007). *

• Skapenko A, Kalden JR, Lipsky PE, Schulze-Koops H. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. J. Immunol. 175: 6107-6116 (2005). *

• Skoglund J, Song B, Dalen J, Dedorson S, Edler D, Hjern F, Holm J, Lenander C, Lindforss U, Lundqvist N, Olivecrona H, Olsson L, Pahlman L, Rutegard J, Smedh K, Tornqvist A, Houlston RS, Lindblom A. Lack of an association between the TGFBR1*6A variant and colorectal cancer risk. Clin. Cancer Res. 13: 3748-3752 (2007). *

• Skov L, Chan LS, Fox DA, Larsen JK, Voorhees JJ, Cooper KD, Baadsgaard O. Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes. Am. J. Pathol. 150: 675-683 (1997). *

• Smeltz RB, Chen J, Shevach EM. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114: 484-492 (2005). *

• Smith AJ, Humphries SE. Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev. 20: 43-59 (2009).

• Smith CE, Miller SD. Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities. J. Autoimmun. 27: 218-231 (2006).

• Smith P, Mangan NE, Walsh CM, Fallon RE, McKenzie AN, van Rooijen N, Fallon PG. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J. Immunol. 178: 4557-4566 (2007). *

• Smits HH, Gloudemans AK, van Nimwegen M, Willart MA, Soullie T, Muskens F, de Jong EC, Boon L, Pilette C, Johansen FE, Hoogsteden HC, Hammad H, Lambrecht BN. Cholera toxin B suppresses allergic inflammation through induction of secretory IgA. Mucosal Immunol. 2: 331-339 (2009). *

• Smolonska J, Wijmenga C, Postma DS, Boezen HM. Meta-analyses on suspected COPD genes - a summary of 20 years' research. Am. J. Respir. Crit. Care Med. 180: 618-631 (2009). *

• Smyth LJ, Kirby JA, Cunningham AC. Role of the mucosal integrin alpha(E)(CD103)beta(7) in tissue-restricted cytotoxicity. Clin. Exp. Immunol. 149: 162-170 (2007). *

• So JS, Lee CG, Kwon HK, Yi HJ, Chae CS, Park JA, Hwang KC, Im SH. Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis. Mol. Immunol. 46: 172-180 (2008). *

• Sofi MH, Liu Z, Zhu L, Yu Q, Kaplan MH, Chang CH. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol. Immunol. Jan 15 [Epub ahead of print] (2010). *

• Sohn BH, Park IY, Lee JJ, Yang SJ, Jang YJ, Park KC, Kim DJ, Lee DC, Sohn HA, Kim TW, Yoo HS, Choi JY, Bae YS, Yeom YI. Functional switching of TGFbeta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter. Gastroenterology Dec 25 [Epub ahead of print] (2009). *

• Sola S, Amaral JD, Castro RE, Ramalho RM, Borralho PM, Kren BT, Tanaka H, Steer CJ, Rodrigues CM. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Hepatology 42: 925-934 (2005). *

• Sola S, Castro RE, Kren BT, Steer CJ, Rodrigues CM. Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. Biochemistry 43: 8429-8438 (2004). *

• Sola S, Ma X, Castro RE, Kren BT, Steer CJ, Rodrigues CM. Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in TGF-beta 1-induced apoptosis of rat hepatocytes. J. Biol. Chem. 278: 48831-48838 (2003). *

• Solini A, Santini E, Madec S, Nannipieri M, Bonotti A, Cuccato S, Ferrannini E. Rosiglitazone increases matrix production and quenches inflammation: studies in human cells. Diabetes Metab. Res. Rev. 24: 197-204 (2007).

• Solomon SS, Odunusi O, Carrigan D, Majumdar G, Kakoola D, Lenchik NI, Gerling IC. TNF-alpha inhibits insulin action in liver and adipose tissue: a model of metabolic syndrome. Horm. Metab. Res. Dec 3 [Epub ahead of print] (2009).

• Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA. Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology 50: 1512-1523 (2009).

• Son G, Iimuro Y, Seki E, Hirano T, Kaneda Y, Fujimoto J. Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G631-G639 (2007). *

• Sonderegger I, Kisielow J, Meier R, King C, Kopf M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 38: 1833-1838 (2008). *

• Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH. Anti-siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J. Immunol. 183: 5333-5341 (2009).

• Song DJ, Min MG, Miller M, Cho JY, Yum HY, Broide DH. Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int. Arch. Allergy Immunol. 151: 285-296 (2009).

• Song L, Wang J, Wang R, Yu M, Sun Y, Han G, Li Y, Qian J, Scott DW, Kang Y, Soukhareva N, Shen B. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4(+) regulatory T cells and TGF-beta? Gene Ther. 11: 1487-1496 (2004).

• Song M, Deaciuc I, Song Z, Barve S, Zhang J, Chen T, Liu M, Arteel G, Brewer G, McClain C. Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis. J. Pharmacol. Exp. Ther. 325: 409-416 (2008). *

• Song SH, Kwak IS, Yang BY, Lee DW, Lee SB, Lee MY. Role of rosiglitazone in lipopolysaccharide-induced peritonitis: a rat peritoneal dialysis model. Nephrology (Carlton) 14: 155-163 (2009). *

• Sonoda E, Matsumoto R, Hitoshi Y, Ishii T, Sugimoto M, Araki S, Tominaga A, Yamaguchi N, Takatsu K. Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production. J. Exp. Med. 1989. 170: 1415-1420. J. Immunol. 182: 14-19 (2009). *

• Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, Hougaard D, Shankaran S, Carlo W; On behalf of the NICHD Neonatal Research Network. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatr. Res. Dec 21 [Epub ahead of print] (2009).

• Sorg BL, Klan N, Seuter S, Dishart D, Radmark O, Habenicht A, Carlberg C, Werz O, Steinhilber D. Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim. Biophys. Acta 1761: 686-697 (2006). *

• Sorice GP, Folli F. A combination of PPAR-gamma agonists and HMG CoA reductase inhibitors (statins) as a new therapy for the conservative treatment of AAS (aortic aneurysm syndromes). Med. Hypotheses 73: 614-618 (2009).

• Soroosh P, Doherty TA. Th9 and allergic disease. Immunology 127: 450-458 (2009). *

• Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landstrom M. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat. Cell Biol. 10: 1199-1207 (2008). *

• Soucek K, Pachernik J, Kubala L, Vondracek J, Hofmanova J, Kozubik A. Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis. Leuk. Res. 30: 607-623 (2006).

• Spatz M, Eibl N, Hink S, Wolf HM, Fischer GF, Mayr WR, Schernthaner G, Eibl MM. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell. Immunol. 221: 5-26 (2003). *

• Spee B, Arends B, van den Ingh TS, Brinkhof B, Nederbragt H, Ijzer J, Roskams T, Penning LC, Rothuizen J. Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies. Liver Int. 26: 716-725 (2006). *

• Spriewald BM, Witzke O, Wassmuth R, Wenzel RR, Arnold ML, Philipp T, Kalden JR. Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. Ann. Rheum. Dis. 64: 457-461 (2005). *

• Srinivasan P, Libbus B. Mining MEDLINE for implicit links between dietary substances and diseases. Bioinformatics 20 Suppl. 1: i290-i296 (2004). *

• Staal A, Birkenhager JC, Pols HA, Buurman CJ, Vink-van Wijngaarden T, Kleinekoort WM, van den Bemd GJ, van Leeuwen JP. Transforming growth factor beta-induced dissociation between vitamin D receptor level and 1,25-dihydroxyvitamin D3 action in osteoblast-like cells. Bone Miner. 26: 27-42 (1994).

• Staal A, van den Bemd GJ, Birkenhager JC, Pols HA, van Leeuwen JP. Consequences of vitamin D receptor regulation for the 1,25-dihydroxyvitamin D3-induced 24-hydroxylase activity in osteoblast-like cells: initiation of the C24-oxidation pathway. Bone 20: 237-243 (1997). *

• Staal A, Van Wijnen AJ, Desai RK, Pols HA, Birkenhager JC, Deluca HF, Denhardt DT, Stein JL, Van Leeuwen JP, Stein GS, Lian JB. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. Endocrinology 137: 2001-2011 (1996).

• Stadnicki A, Machnik G, Klimacka-Nawrot E, Wolanska-Karut A, Labuzek K. Transforming growth factor-beta1 and its receptors in patients with ulcerative colitis. Int. Immunopharmacol. 9: 761-766 (2009).

• Stahle-Backdahl M, Maim J, Veress B, Benoni C, Bruce K, Egesten A. Increased presence of eosinophilic granulocytes expressing transforming growth factor-beta1 in collagenous colitis. Scand. J. Gastroenterol. 35: 742-746 (2000). *

• Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA. Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules. Arthritis Rheum. 58: 1601-1608 (2008). *

• Stanke F, Becker T, Hedtfeld S, Tamm S, Wienker TF, Tummler B. Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. Hum. Genet. Jan 3 [Epub ahead of print] (2010). *

• Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, Hromas R. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167: 4137-4140 (2001). *

• Staroslawska E, Czarnocki KJ, Koziol-Montewka M, Donica H, Magrys A. Effect of infliximab on the levels of TNF-alpha and TGF-beta in the whole blood cultures of irradiated patients. Folia Histochem. Cytobiol. 46: 291-297 (2008).

• Stasikowska O, Danilewicz M, Wagrowska-Danilewicz M. The significant role of RANTES and CCR5 in progressive tubulointerstitial lesions in lupus nephropathy. Pol. J. Pathol. 58: 35-40 (2007).

• Stassen M, Schmitt E, Jonuleit H. Human CD(4+)CD(25+) regulatory T cells and infectious tolerance. Transplantation 77: S23-S25 (2004).

• Stavnezer J, Kang J. The surprising discovery that TGF beta specifically induces the IgA class switch. J. Immunol. 182: 5-7 (2009). *

• Stechova K, Pomahacova R, Hrabak J, Durilova M, Sykora J, Chudoba D, Stavikova V, Flajsmanova K, Varvarovska J. Reactivity to Helicobacter pylori antigens in patients suffering from thyroid gland autoimmunity. Exp. Clin. Endocrinol. Diabetes 117: 423-431 (2009).

• Stefanovic B, Lindquist J, Rippe RA, Schnabl B, Schwabe R, Bataller R, Brenner DA. Prevention and treatment of hepatic fibrosis at the cellular level. J. Gastroenterol. Hepatol. 19: S246-S252 (2004). *

• Stephanie Gu Y, Kong J, Cheema GS, Keen CL, Wick G, Gershwin ME. The immunobiology of systemic sclerosis. Semin. Arthritis Rheum. 38: 132-160 (2008). *

• Steptoe RJ, Ritchie JM, Jones LK, Harrison LC. Autoimmune diabetes is suppressed by transfer of proinsulin-encoding gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells. Diabetes 54: 434-442 (2005). *

• Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL. Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc. Natl. Acad. Sci. U.S.A. 105: 5172-5176 (2008). *

• Sthoeger ZM, Sharabi A, Molad Y, Asher I, Zinger H, Dayan M, Mozes E. Treatment of lupus patients with a tolerogenic peptide, hCDR1 (edratide): immunomodulation of gene expression. J. Autoimmun. 33: 77-82 (2009).

• Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and adaptive immunity. Semin. Immunol. 19: 353-361 (2007). *

• Stockis J, Colau D, Coulie PG, Lucas S. Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur. J. Immunol. 39: 3315-3322 (2009). *

• Stoffers KL, Sorg BL, Seuter S, Rau O, Radmark O, Steinhilber D. Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene. J. Mol. Biol. Oct 15 [Epub ahead of print] (2009). *

• Stojanovic I, Cvjeticanin T, Lazaroski S, Stosic-Grujicic S, Miljkovic D. Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells. Immunology 126: 74-83 (2009). *

• Stolina M, Bolon B, Middleton S, Dwyer D, Brown H, Duryea D, Zhu L, Rohner A, Pretorius J, Kostenuik P, Feige U, Zack D. The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis. J. Clin. Immunol. 29: 158-174 (2009). *

• Stoop JN, Woltman AM, Biesta PJ, Kusters JG, Kuipers EJ, Janssen HL, van der Molen RG. Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response. Hepatology 46: 699-705 (2007). *

• Stosic-Grujicic S, Stojanovic I, Maksimovic-Ivanic D, Momcilovic M, Popadic D, Harhaji L, Miljkovic D, Metz C, Mangano K, Papaccio G, Al-Abed Y, Nicoletti F. Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus. J. Cell Physiol. 215: 665-675 (2008). *

• Strauch UG, Obermeier F, Grunwald N, Gurster S, Dunger N, Schultz M, Griese DP, Mahler M, Scholmerich J, Rath HC. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 54: 1546-1552 (2005). *

• Straumann A, Conus S, Grzonka P, Kita H, Kephart G, Bussmann C, Beglinger C, Smith D, Patel J, Byrne M, Simon HU. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomized, placebo-controlled, double-blind trial. Gut 59: 21-30 (2010).

• Strauss-Ayali D, Baneth G, Jaffe CL. Splenic immune responses during canine visceral leishmaniasis. Vet. Res. 38: 547-564 (2007). *

• Strober W. Vitamin A rewrites the ABCs of oral tolerance. Mucosal Immunol. 1: 92-95 (2008).

• Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, Neurath M. Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol. Today 18: 61-64 (1997).

• Strober W, Ludviksson BR, Fuss IJ. The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease. Ann. Intern. Med. 128: 848-856 (1998). *

• Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7: 937-945 (2006). *

• Sturm A, Dignass AU. Epithelial restitution and wound healing in inflammatory bowel disease. World J. Gastroenterol. 14: 348-353 (2008). *

• Sturm A, Schulte C, Schatton R, Becker A, Cario E, Goebell H, Dignass AU. Transforming growth factor-beta and hepatocyte growth factor plasma levels in patients with inflammatory bowel disease. Eur. J. Gastroenterol. Hepatol. 12: 445-450 (2000).

• Su H, Ye DQ, Wang BL, Fang XH, Chen J, Wang Q, Li WX, Zhang N. Transforming growth factor-beta1-induced CD4+CD25+ regulatory T cells in vitro reverse and prevent a murine lupus-like syndrome of chronic graft-versus-host disease. Br. J. Dermatol. 158: 1197-1209 (2008). *

• Su Y, Huang X, Raskovalova T, Zacharia L, Lokshin A, Jackson E, Gorelik E. Cooperation of adenosine and prostaglandin E(2) (PGE (2)) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol. Immunother. 57: 1611-1623 (2008).

• Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes 57: 3281-3288 (2008). *

• Subramaniam MM, Chan JY, Yeoh KG, Quek T, Ito K, Salto-Tellez M. Molecular pathology of RUNX3 in human carcinogenesis. Biochim. Biophys. Acta 1796: 315-331 (2009). *

• Suenaert P, Maerten P, Van Assche G, Van Driessche W, Geboes K, Bulteel V, Simaels J, Augustijns P, Ceuppens JL, Rutgeerts P, Perrier C. Effects of T cell-induced colonic inflammation on epithelial barrier function. Inflamm. Bowel Dis. Feb 12 [Epub ahead of print] (2010). *

• Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M. The pathogenesis of oral lichen planus. Crit. Rev. Oral Biol. Med. 13: 350-365 (2002). *

• Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J. Immunol. 183: 5013-5022 (2009).

• Sugita S, Ng TF, Lucas PJ, Gress RE, Streilein JW. B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells. J. Immunol. 176: 118-127 (2006). *

• Sugiura Y, Banno S, Matsumoto Y, Niimi T, Yoshinouchi T, Hayami Y, Naniwa T, Ueda R. Transforming growth factor beta1 gene polymorphism in patients with systemic sclerosis. J. Rheumatol. 30: 1520-1523 (2003).

• Suk FM, Chen CH, Lin SY, Cheng CJ, Yen SJ, Hung LF, Liu DZ, Liang YC. 15-Deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. Toxicol. Lett. 187: 22-27 (2009).

• Suk LY, Beak CH, In Kyu L, Gyu KT, Teak OS. Association between IL-4R and TGF-beta1 gene polymorphisms and the risk of colorectal cancer in a Korean population. Colorectal Dis. Oct 22 [Epub ahead of print] (2009). *

• Sumida Y, Nakamura K, Kanayama K, Akiho H, Teshima T, Takayanagi R. Preparation of functionally preserved CD4+ CD25high regulatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell transfer therapy. Cytotherapy 10: 698-710 (2008).

• Sumitran-Holgersson S, Ge X, Karrar A, Xu B, Nava S, Broome U, Nowak G, Ericzon BG. A novel mechanism of liver allograft rejection facilitated by antibodies to liver sinusoidal endothelial cells. Hepatology 40: 1211-1221 (2004). *

• Sumnik Z, Cinek O, Bratanic N, Kordonouri O, Kulich M, Roszai B, Arato A, Lebl J, Soltesz G, Danne T, Battelino T, Schober E. Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 andTNF -308A. Diabetes Care 29: 858-863 (2006). *

• Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204: 1775-1785 (2007). *

• Sun JB, Czerkinsky C, Holmgren J. Mucosally induced immunological tolerance, regulatory T cells and the adjuvant effect by cholera toxin B subunit. Scand. J. Immunol. 71: 1-11 (2010). *

• Sun JB, Raghavan S, Sjoling A, Lundin S, Holmgren J. Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells. J. Immunol. 177: 7634-7644 (2006). *

• Sun K, Wang Q, Huang XH. PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. Acta Pharmacol. Sin. 27: 715-723 (2006). *

• Sun Y, Wu XX, Yin Y, Gong FY, Shen Y, Cai TT, Zhou XB, Wu XF, Xu Q. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem. Pharmacol. 79: 229-238 (2010). *

• Sundrud MS, Rao A. New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT. Curr. Opin. Immunol. 19: 287-293 (2007).

• Suri-Payer E, Fritzsching B. Regulatory T cells in experimental autoimmune disease. Springer Semin. Immunopathol. 28: 3-16 (2006). *

• Sutcigil L, Oktenli C, Musabak U, Bozkurt A, Cansever A, Uzun O, Sanisoglu SY, Yesilova Z, Ozmenler N, Ozsahin A, Sengul A. Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy. Clin. Dev. Immunol. 2007: 76396 (2007). *

• Suto A, Kashiwakuma D, Kagami SI, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205: 1369-1379 (2008). *

• Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341 (2009). *

• Suzuki M, Konya C, Goronzy JJ, Weyand CM. Inhibitory CD8(+) T cells in autoimmune disease. Hum. Immunol. 69: 781-789 (2008).

• Suzuki R, Miyamoto S, Yasui Y, Sugie S, Tanaka T. Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. BMC Cancer 7: 84 (2007). *

• Svegliati-Baroni G, Inagaki Y, Rincon-Sanchez AR, Else C, Saccomanno S, Benedetti A, Ramirez F, Rojkind M. Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent. Hepatology 42: 343-352 (2005). *

• Syn WK, Yang L, Chiang D, Qian Y, Jung Y, Karaca G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 29: 1262-1272 (2009). *

• Szalay G, Sauter M, Haberland M, Zuegel U, Steinmeyer A, Kandolf R, Klingel K. Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Circ. Res. 104: 851-859 (2009). *

• Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M. Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Biochem. Pharmacol. 78: 301-314 (2009). *

• Tabata C, Tabata R, Hirayama N, Yasumitsu A, Yamada S, Murakami A, Iida S, Tamura K, Terada T, Kuribayashi K, Fukuoka K, Nakano T. All-trans-retinoic acid inhibits tumour growth of malignant pleural mesothelioma in mice. Eur. Respir. J. 34: 1159-1167 (2009).

• Tabata C, Tabata R, Kadokawa Y, Hisamori S, Takahashi M, Mishima M, Nakano T, Kubo H. Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice. J. Immunol. 179: 708-714 (2007). *

• Tabe Y. Molecular diagnosis of and molecular targeting therapy for leukemia. Rinsho Byori 57: 137-145 (2009).

• Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig. Dis. Sci. 52: 3404-3415 (2007). *

• Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn IA. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. J. Autoimmun. 23: 103-115 (2004).

• Taherkhani H, Hajilooi M, Fallah M, Khyabanchi O, Haidari M. Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to giardiasis. Int. J. Immunogenet. 36: 345-349 (2009). *

• Taimr P. Fibrogenesis, hepatic stellate cells and immune system. Falk Symposium 135. Immmunological diseases of liver and gut. Prague (Czech Republic). p. 26. September 12 - 13 (2003). *

• Tajik N, Kazemi T, Delbandi A, Ghods A, Salek Moghaddam A. The predictive value of HLA-DR matching and cytokine gene polymorphisms in renal allograft acute rejection: a living-unrelated donor (LURD) study. Iran. J. Immunol. 3: 150-156 (2006).

• Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H. TNF-alpha regulates TGF-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J. Biol. Chem. Dec 4 [Epub ahead of print] (2009). *

• Takahashi T, Ono H, Ono Y, Ishimitsu T, Matsuoka H. Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). Int. Heart J. 48: 637-647 (2007).

• Takahata Y, Nomura A, Takada H, Ohga S, Furuno K, Hikino S, Nakayama H, Sakaguchi S, Hara T. CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp. Hematol. 32: 622-629 (2004). *

• Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T. STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J. Biol. Chem. 283: 14955-14962 (2008). *

• Takatori H, Kanno Y, Chen Z, O'Shea JJ. New complexities in helper T cell fate determination and the implications for autoimmune diseases. Mod. Rheumatol. 18: 533-541 (2008). *

• Takebayashi K, Hokari R, Kurihara C, Okada Y, Okudaira K, Matsunaga H, Komoto S, Watanabe C, Kawaguchi A, Nagao S, Tsuzuki Y, Miura S. Oral tolerance induced by enterobacteria altered the process of lymphocyte recruitment to intestinal microvessels: roles of endothelial cell adhesion molecules, TGF-beta and negative regulators of TLR signaling. Microcirculation 16: 251-264 (2009). *

• Takeda M, Yamada H, Iwabuchi K, Shimada S, Naito M, Sakuragi N, Minakami H, Onoe K. Administration of high-dose intact immunoglobulin has an anti-resorption effect in a mouse model of reproductive failure. Mol. Hum. Reprod. 13: 807-814 (2007).

• Takehara T, Tatsumi T, Suzuki T, Rucker EB, Hennighausen L, Jinushi M, Miyagi T, Kanazawa Y, Hayashi N. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 127: 1189-1197 (2004). *

• Takeshita A, Imai K, Kato S, Kitano S, Hanazawa S. 1alpha,25-dehydroxyvitamin D3 synergism toward transforming growth factor-beta1-induced AP-1 transcriptional activity in mouse osteoblastic cells via its nuclear receptor. J. Biol. Chem. 273: 14738-14744 (1998). *

• Tallima H, Salah M, Guirguis FR, El Ridi R. Transforming growth factor-beta and Th17 responses in resistance to primary murine Schistosomiasis mansoni. Cytokine 48: 239-245 (2009).

• Talukdar R, Saikia N, Singal DK, Tandon R. Chronic pancreatitis: evolving paradigms. Pancreatology 6: 440-449 (2006).

• Talukdar R, Tandon RK. Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. J. Gastroenterol. Hepatol. 23: 34-41 (2008). *

• Tamaki N, Hatano E, Taura K, Tada M, Kodama Y, Nitta T, Iwaisako K, Seo S, Nakajima A, Ikai I, Uemoto S. CHOP-deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G498-G505 (2008). *

• Tamizifar B, Bagheri-Lankarani K, Naeemi S, Rismankar-Zadeh M, Taghavi A, Ghaderi A. Polymorphism of the promoter region of C-509T of transforming growth factor-beta1 gene and ulcerative colitis. Arch. Iran. Med. 10: 171-175 (2007).

• Tamizifar B, Lankarani KB, Naeimi S, Rismankar Zadeh M, Taghavi A, Ghaderi A. Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis. World J. Gastroenterol. 14: 243-247 (2008). *

• Tan NS, Michalik L, Desvergne B, Wahli W. Genetic- or TGF-beta 1-induced changes in epidermal PPARbeta/delta expression dictate wound repair kinetics. J. Biol. Chem. 280: 18163-18170 (2005). *

• Tan PH, Sagoo P, Chan C, Yates JB, Campbell J, Beutelspacher SC, Foxwell BM, Lombardi G, George AJ. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J. Immunol. 174: 7633-7644 (2005). *

• Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J. Am. Soc. Nephrol. 17: 3382-3393 (2006). *

• Tan YV, Abad C, Lopez R, Dong H, Liu S, Lee A, Gomariz RP, Leceta J, Waschek JA. Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 106: 2012-2017 (2009). *

• Tanabe S, Kinuta Y, Saito Y. Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation. Int. J. Mol. Med. 22: 181-185 (2008). *

• Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J. Immunol. 180: 3746-3756 (2008). *

• Tanaka T, Oh-Hashi K, Shitara H, Hirata Y, Kiuchi K. NF-kappaB independent signaling pathway is responsible for LPS-induced GDNF gene expression in primary rat glial cultures. Neurosci. Lett. 431: 262-267 (2008).

• Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34: 2996-3005 (2004). *

• Tang Y, Desierto MJ, Chen J, Young NS. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure. Blood Nov 10 [Epub ahead of print] (2009). *

• Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc. Natl. Acad. Sci. U.S.A. 105: 2445-2450 (2008). *

• Tangkijvanich P, Yee HF Jr. Cirrhosis - can we reverse hepatic fibrosis? Eur. J. Surg. Suppl. 587: 100-112 (2002).

• Taniguchi E, Kin M, Torimura T, Nakamura T, Kumemura H, Hanada S, Hisamoto T, Yoshida T, Kawaguchi T, Baba S, Maeyama M, Koga H, Harada M, Kumashiro R, Ueno T, Mizuno S, Ikeda H, Imaizumi T, Murohara T, Sata M. Endothelial progenitor cell transplantation improves the survival following liver injury in mice. Gastroenterology 130: 521-531 (2006). *

• Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 13: 1096-1101 (2007). *

• Tansini A, de Medeiros BM. Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation. Scand. J. Immunol. 69: 310-318 (2009). *

• Tardif G, Reboul P, Pelletier JP, Martel-Pelletier J. Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3). Mod. Rheumatol. 14: 197-204 (2004).

• Tartar DM, Vanmorlan AM, Wan X, Guloglu FB, Jain R, Haymaker CL, Ellis JS, Hoeman CM, Cascio JA, Dhakal M, Oukka M, Zaghouani H. FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J. Immunol. Feb 24 [Epub ahead of print] (2010).

• Tato CM, Cua DJ. Reconciling id, ego, and superego within interleukin-23. Immunol. Rev. 226: 103-111 (2008). *

• Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology Oct 13 [Epub ahead of print] (2009). *

• Taylor A, Verhagen J, Akdis CA, Akdis M. T regulatory cells in allergy and health: a question of allergen specificity and balance. Int. Arch. Allergy Immunol. 135: 73-82 (2004).

• Taylor AW, Kitaichi N. The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy. Brain Behav. Immun. 22: 639-646 (2008).

• Taylor KR, Yamasaki K, Radek KA, Di Nardo A, Goodarzi H, Golenbock D, Beutler B, Gallo RL. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44 and MD-2. J. Biol. Chem. 282: 18265-18275 (2007). *

• Taylor MD, Harris A, Nair MG, Maizels RM, Allen JE. F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. J. Immunol. 176: 6918-6927 (2006). *

• Teixeira-Clerc F, Julien B, Grenard P, Van Nhieu JT, Deveaux V, Li L, Serriere-Lanneau V, Ledent C, Mallat A, Lotersztajn S. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat. Med. 12: 671-676 (2006). *

• Teixeira-Salum TB, Rodrigues DB, Gervasio AM, Souza CJ, Rodrigues Jr V, Loyola AM. Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. J. Oral Pathol. Med. Jan 21 [Epub ahead of print] (2010).

• Tenesa A, Dunlop MG. New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat. Rev. Genet. 10: 353-358 (2009). *

• Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ. Runx2 regulates G-protein coupled signaling pathways to control growth of osteoblast progenitors. J. Biol. Chem. 283: 27585-27597 (2008). *

• Terabe M, Ambrosino E, Takaku S, O'Konek JJ, Venzon D, Lonning S, McPherson JM, Berzofsky JA. Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody. Clin. Cancer Res. 15: 6560-6569 (2009).

• Terao M, Murota H, Kitaba S, Katayama I. Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma. Exp. Dermatol. Sep 16 [Epub ahead of print] (2009).

• Teufel A, Staib F, Kanzler S, Weinmann A, Schulze-Bergkamen H, Galle PR. Genetics of hepatocellular carcinoma. World J. Gastroenterol. 13: 2271-2282 (2007). *

• Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki T. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448: 929-933 (2007). *

• Thebault P, Lhermite N, Tilly G, Le Texier L, Quillard T, Heslan M, Anegon I, Soulillou JP, Brouard S, Charreau B, Cuturi MC, Chiffoleau E. The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J. Immunol. 183: 3099-3108 (2009).

• Thenappan A, Li Y, Kitisin K, Rashid A, Shetty K, Johnson L, Mishra L. Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver. Hepatology Nov 30 [Epub ahead of print] (2009). *

• Thiebaud D, Guenther HL, Porret A, Burckhardt P, Fleisch H, Hofstetter W. Regulation of collagen type I and biglycan mRNA levels by hormones and growth factors in normal and immortalized osteoblastic cell lines. J. Bone Miner. Res. 9: 1347-1354 (1994).

• Thielitz A, Ansorge S, Bank U, Tager M, Wrenger S, Gollnick H, Reinhold D. The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases. Front. Biosci. 13: 2364-2375 (2008).

• Thielitz A, Reinhold D, Vetter R, Bank U, Helmuth M, Hartig R, Wrenger S, Wiswedel I, Lendeckel U, Kahne T, Neubert K, Faust J, Zouboulis CC, Ansorge S, Gollnick H. Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation. J. Invest. Dermatol. 127: 1042-1051 (2007). *

• Thielitz A, Vetter RW, Schultze B, Wrenger S, Simeoni L, Ansorge S, Neubert K, Faust J, Lindenlaub P, Gollnick HP, Reinhold D. Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts. J. Invest. Dermatol. 128: 855-866 (2008). *

• Thienprasert A, Samuhaseneetoo S, Popplestone K, West AL, Miles EA, Calder PC. Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: a randomized, double-blind, placebo-controlled intervention trial. J. Pediatr. 154: 391-395 (2009). *

• Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SA, Fung J, Gandhi CR. Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. Gut 53: 1010-1019 (2004). *

• Thompson C, Powrie F. Regulatory T cells. Curr. Opin. Pharmacol. 4: 408-414 (2004).

• Thompson JS, Chu Y, Glass JF, Brown SA. Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD. Bone Marrow Transplant. Aug 31 [Epub ahead of print] (2009).

• Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. Feb 24 [Epub ahead of print] (2010).

• Thornton CA, Morgan G. Innate and adaptive immune pathways to tolerance. Nestle Nutr. Workshop Ser. Pediatr. Program 64: 45-61 (2009).

• Thorvaldson L, Sandler S. Factors influencing the regulation of cytokine balance during islet transplantation in mice. Transpl. Immunol. 20: 186-194 (2009).

• Tian L, Lappalainen J, Autero M, Hanninen S, Rauvala H, Gahmberg CG. Shedded neuronal ICAM-5 suppresses T cell activation. Blood 111: 3615-3625 (2008). *

• Tiao MM, Lu L, Huang LT, Liang CD, Chen CL, Tao R, Fung JJ, Qian S. Cross-tolerance of recipient-derived transforming growth factor-beta dendritic cells. Transplant. Proc. 39: 281-282 (2007). *

• Tiegs G, Lohse AW. Immune tolerance: what is unique about the liver. J. Autoimmun. Aug 28 [Epub ahead of print] (2009).

• Tien YW, Wu YM, Lin WC, Lee HS, Lee PH. Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells. J. Hepatol. 51: 307-314 (2009).

• Tiittanen M, Huupponen JT, Knip M, Vaarala O. Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro. Diabetes 55: 3446-3454 (2006). *

• Tiittanen M, Westerholm-Ormio M, Verkasalo M, Savilahti E, Vaarala O. Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes. Clin. Exp. Immunol. 152: 498-507 (2008). *

• Tilg H, Moschen A, Kaser A. Mode of function of biological anti-TNF agents in the treatment of inflammatory bowel diseases. Expert Opin. Biol. Ther. 7: 1051-1059 (2007).

• Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 31: 145-157 (2009). *

• Toblli JE, Munoz MC, Cao G, Mella J, Pereyra L, Mastai R. ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats. Obesity (Silver Spring) 16: 770-776 (2008). *

• Toda A, Piccirillo CA. Development and function of naturally occurring CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 80: 458-470 (2006). *

• Toh ML, Miossec P. The role of T cells in rheumatoid arthritis: new subsets and new targets. Curr. Opin. Rheumatol. 19: 284-288 (2007).

• Tokuyama H, Tokuyama Y. The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching. Cell. Immunol. 192: 41-47 (1999). *

• Tokuyama H, Tokuyama Y. Endogenous cytokine expression profiles in retinoic acid-induced IgA production by LPS-stimulated murine splenocytes. Cell. Immunol. 166: 247-253 (1995). *

• Tokuyama H, Tokuyama Y. Retinoids enhance IgA production by lipopolysaccharide-stimulated murine spleen cells. Cell. Immunol. 150: 353-363 (1993). *

• Tokuyama H, Tokuyama Y. Retinoic acid induces the expression of germ-line C alpha transcript mainly by a TGF-beta-independent mechanism. Cell. Immunol. 176: 14-21 (1997). *

• Tokuyama H, Tokuyama Y, Nakanishi K. Retinoids inhibit IL-4-dependent IgE and IgG1 production by LPS-stimulated murine splenic B cells. Cell. Immunol. 162: 153-158 (1995). *

• Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H, Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T, Hibi T. Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Hepatology 48: 458-473 (2008). *

• Tomiya T, Omata M, Imamura H, Fujiwara K. Impaired liver regeneration in acute liver failure: the significance of cross-communication of growth associated factors in liver regeneration. Hepatol. Res. 38 (s1: The 6 Japan Society of Hepatology Single Topic Conference: Liver Failure: Recent Progress and Pathogenesis to Management. 28-29 September 2007, Iwate, Japan): S29-S33 (2008). *

• Tomlinson JW, Durrani OM, Bujalska IJ, Gathercole LL, Tomlins PJ, Reuser TT, Rose GE, Curnow SJ, Stewart PM, Walker EA, Rauz S. The role of 11ss-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy. J. Clin. Endocrinol. Metab. Oct 30 [Epub ahead of print] (2009).

• Tomoda A, Joudoi T, Rabab el-M, Matsumoto T, Park TH, Miike T. Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls. Psychiatry Res. 134: 101-104 (2005).

• Toms C, Jessup H, Thompson C, Baban D, Davies K, Powrie F. Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Immunology 125: 302-312 (2008). *

• Tong T, Zhao W, Wu YQ, Chang Y, Wang QT, Zhang LL, Wei W. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis. Inflamm. Res. Oct 28 [Epub ahead of print] (2009). *

• Tong Z, Chen R, Alt DS, Kemper S, Perbal B, Brigstock DR. Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology 50: 939-947 (2009).

• Tonkin DR, He J, Barbour G, Haskins K. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181: 4516-4522 (2008). *

• Torchinsky MB, Blander JM. T helper 17 cells: discovery, function, and physiological trigger. Cell. Mol. Life Sci. Jan 7 [Epub ahead of print] (2010). *

• Torchinsky MB, Garaude J, Martin AP, Blander JM. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature 458: 78-82 (2009). *

• Torer N, Ozenirler S, Yucel A, Bukan N, Erdem O. Importance of cytokines, oxidative stress and expression of BCL-2 in the pathogenesis of non-alcoholic steatohepatitis. Scand. J. Gastroenterol. 42: 1095-1101 (2007). *

• Torres MI, Lopez-Casado MA, Lorite P, Rios A. Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease. Clin. Exp. Immunol. 148: 419-424 (2007). *

• Torres-Aguilar H, Aguilar-Ruiz SR, Gonzalez-Perez G, Munguia R, Bajana S, Meraz-Rios MA, Sanchez-Torres C. Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Toubia N, Schubert ML. Menetrier's disease. Curr. Treat. Options Gastroenterol. 11: 103-108 (2008).

• Toukap AN, Galant C, Theate I, Maudoux AL, Lories RJ, Houssiau FA, Lauwerys BR. Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus. Arthritis Rheum. 56: 1579-1588 (2007). *

• Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat. Med. 14: 681-687 (2008). *

• Towsend K, Trevino V, Falciani F, Stewart PM, Hewison M, Campbell MJ. Identification of VDR-responsive gene signatures in breast cancer cells. Oncology 71: 111-123 (2007).

• Trajkov D, Arsov T, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Gogusev J, Spiroski M. Distribution of the 22 cytokine gene polymorphisms in healthy Macedonian population. Bratisl. Lek. Listy. 110: 7-17 (2009).

• Trappoliere M, Caligiuri A, Schmid M, Bertolani C, Failli P, Vizzutti F, Novo E, di Manzano C, Marra F, Loguercio C, Pinzani M. Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. J. Hepatol. 50: 1102-1111 (2009).

• Trauner M, Fickert P, Moustafa T, Guelly C, Fuchsbichler A, Denk H, Wagner M, Zollner G. Side chain-shortened bile acids for the treatment of cholestasis: lessons from nor-ursodeoxycholic acid. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 77-78 (2006). *

• Traves SL, Donnelly LE. Th17 cells in airway diseases. Curr. Mol. Med. 8: 416-426 (2008).

• Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta(8) on dendritic cells causes autoimmunity and colitis in mice. Nature 449: 361-366 (2007). *

• Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin independent pathway. Gastroenterology 136: 1680-1688.e7 (2009). *

• Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R. Silencing of the TGFbeta receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. J. Biol. Chem. 284: 6291-6300 (2009). *

• Tsai YG, Chiou YL, Chien JW, Wu HP, Lin CY. Induction of IL-10+ CD4+ CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy. Pediatr. Allergy Immunol. Aug 13 [Epub ahead of print] (2009). *

• Tsantikos E, Quilici C, Harder KW, Wang B, Zhu HJ, Anderson GP, Tarlinton DM, Hibbs ML. Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice. J. Immunol. 183: 2484-2494 (2009).

• Tsiavou A, Hatziagelaki E, Chaidaroglou A, Manginas A, Koniavitou K, Degiannis D, Raptis SA. TNF-alpha, TGF-beta1, IL-10, IL-6, gene polymorphisms in latent autoimmune diabetes of adults (LADA) and type 2 diabetes mellitus. J. Clin. Immunol. 24: 591-599 (2004). *

• Tsikrikoni A, Kyriakou DS, Rigopoulou EI, Alexandrakis MG, Zachou K, Passam F, Dalekos GN. Markers of cell activation and apoptosis in bone marrow mononuclear cells of patients with autoimmune hepatitis type 1 and primary biliary cirrhosis. J. Hepatol. 42: 393-399 (2005). *

• Tsuji NM. Antigen-specific CD4(+) regulatory T cells in the intestine. Inflamm. Allergy Drug Targets 5: 191-201 (2006).

• Tsukamoto H. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin. Exp. Res. 23: 911-916 (1999). *

• Tsuzaka K, Nozaki K, Kumazawa C, Shiraishi K, Setoyama Y, Yoshimoto K, Abe T, Takeuchi T. TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients. Springer Semin. Immunopathol. 28: 185-193 (2006). *

• Turpie B, Yoshimura T, Gulati A, Rios JD, Dartt DA, Masli S. Sjogren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am. J. Pathol. 175: 1136-1147 (2009). *

• Tutau F, Rodríguez-Ortigosa C, Puche JE, Juanarena N, Monreal I, García Fernandez M, Clavijo E, Castilla A, Castilla-Cortazar I. Enhanced actions of insulin-like growth factor-I and interferon-alpha co-administration in experimental cirrhosis. Liver Int. 29: 37-46 (2009). *

• Tzachanis D, Li L, Lafuente EM, Berezovskaya A, Freeman GJ, Boussiotis VA. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood 109: 2944-2952 (2007). *

• Uchida H, Kuroki M, Shitama T, Hayashi H, Kuroki M. Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells. Curr. Eye Res. 33: 199-203 (2008).

• Uchinami H, Seki E, Brenner DA, D'Armiento J. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology 44: 420-429 (2006). *

• Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M. TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. J. Allergy Clin. Immunol. 121: 659-664 (2008). *

• Ueki M, Koda M, Yamamoto S, Matsunaga Y, Murawaki Y. Preventive and therapeutic effects of angiotensin II type 1 receptor blocker on hepatic fibrosis induced by bile duct ligation in rats. J. Gastroenterol. 41: 996-1004 (2006). *

• Ulukaya S, Basturk B, Kilic M, Ulukaya E. Cytokine gene polymorphism and postreperfusion syndrome during orthotopic liver transplantation. Transplant. Proc. 40: 1290-1293 (2008).

• Umeda M, Kushida T, Sasai K, Asada T, Oe K, Sakai D, Mochida J, Ikehara S, Iida H. Activation of rat nucleus pulposus cells by coculture with whole bone marrow cells collected by the perfusion method. J. Orthop. Res. 27: 222-228 (2008).

• Umemura M, Kawabe T, Shudo K, Kidoya H, Fukui M, Asano M, Iwakura Y, Matsuzaki G, Imamura R, Suda T. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol. 16: 1099-1108 (2004). *

• Unitt E, Rushbrook SM, Marshall A, Davies S, Gibbs P, Morris LS, Coleman N, Alexander GJ. Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41: 722-730 (2005). *

• Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T. Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Hepatology 48: 109-118 (2008). *

• Uran PA, Goncalves AA, Taverne-Thiele JJ, Schrama JW, Verreth JA, Rombout JH. Soybean meal induces intestinal inflammation in common carp (Cyprinus carpio L.). Fish Shellfish Immunol. 25: 751-760 (2008).

• Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M. Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J. Immunol. 171: 708-716 (2003). *

• Urtasun R, Cubero FJ, Vera M, Nieto N. Reactive nitrogen species up-regulate TNFalpha and matrix metalloproteinases and protect against liver fibrogenesis. Gastroenterology 136: 1410-1422.e4 (2009). *

• Urtasun R, de la Rosa LC, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin. Liver Dis. 12: 769-790, viii (2008).

• Usui T. Transcription factors that regulate helper T cell differentiation. Nihon Rinsho Meneki Gakkai Kaishi 30: 419-427 (2007). *

• Usui Y, Takeuchi M, Hattori T, Okunuki Y, Nagasawa K, Kezuka T, Okumura K, Yagita H, Akiba H, Goto H. Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice. Arch. Ophthalmol. 127: 514-519 (2009). *

• Uto H, Nakanishi C, Ido A, Hasuike S, Kusumoto K, Abe H, Numata M, Nagata K, Hayashi K, Tsubouchi H. The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, L-amino acid-defined diet. Hepatol. Res. 32: 235-242 (2005).

• Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 108: 253-261 (2006). *

• Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM. TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G116-G128 (2005). *

• Valle L, Serena-Acedo T, Liyanarachchi S, Hampel H, Comeras I, Li Z, Zeng Q, Zhang HT, Pennison MJ, Sadim M, Pasche B, Tanner SM, de la Chapelle A. Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. Science 321: 1361-1365 (2008). *

• Van Assche G, Geboes K, Rutgeerts P. Medical therapy for Crohn's disease strictures. Inflamm. Bowel Dis. 10: 55-60 (2004). *

• van Beelen AJ, Teunissen MB, Kapsenberg ML, de Jong EC. Interleukin-17 in inflammatory skin disorders. Curr. Opin. Allergy Clin. Immunol. 7: 374-381 (2007). *

• Van Bruaene N, Perez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, Schmidt-Weber C, Akdis C, Van Cauwenberge P, Bachert C, Gevaert P. T-cell regulation in chronic paranasal sinus disease. J. Allergy Clin. Immunol. 121: 1435-1441, e1-e3 (2008). *

• van der Paardt M, Crusius JB, Garcia-Gonzalez MA, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE. Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta1 (TGFB1) gene polymorphisms. Ann. Rheum. Dis. 64: 616-619 (2005). *

• van Deventer SJ. Immunology in medical practice. IV. Inflammatory bowel diseases: pathogenic starting points for specific therapy. Ned. Tijdschr. Geneeskd. 141: 1956-1959 (1997).

• van Hamburg JP, de Bruijn MJ, de Almeida CR, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38: 2573-2586 (2008). *

• van Oosterhout AJ, Bloksma N. Regulatory T-lymphocytes in asthma. Eur. Respir. J. 26: 918-932 (2005). *

• van Puijvelde GH, Hauer AD, de Vos P, van den Heuvel R, van Herwijnen MJ, van der Zee R, van Eden W, van Berkel TJ, Kuiper J. Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114: 1968-1976 (2006). *

• van Roon JA, Bijlsma JW, Lafeber FP. Diversity of regulatory T cells to control arthritis. Best Pract. Res. Clin. Rheumatol. 20: 897-913 (2006).

• Van Seuningen I, Pigny P, Perrais M, Porchet N, Aubert JP. Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front. Biosci. 6: D1216-D1234 (2001).

• van Strien ME, Mercier D, Drukarch B, Breve JJ, Poole S, Binnekade R, Bol JG, Blits B, Verhaagen J, van Dam AM. Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages. Gene Ther. Feb 25 [Epub ahead of print] (2010).

• Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P, Bachert C. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61: 1280-1289 (2006). *

• Varga J, Pasche B. Antitransforming growth factor-beta therapy in fibrosis: recent progress and implications for systemic sclerosis. Curr. Opin. Rheumatol. 20: 720-728 (2008).

• Varga J, Pasche B. Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat. Rev. Rheumatol. 5: 200-206 (2009). *

• Vasu C, Gorla SR, Prabhakar BS, Holterman MJ. Targeted engagement of CTLA-4 prevents autoimmune thyroiditis. Int. Immunol. 15: 641-654 (2003). *

• Vasu C, Prabhakar BS, Holterman MJ. Targeted CTLA-4 engagement induces CD4(+)CD25(+)CTLA-4(high) T regulatory cells with target (allo)antigen specificity. J. Immunol. 173: 2866-2876 (2004). *

• Veaute C, Andreoli MF, Racca A, Bailat A, Scalerandi MV, Bernal C, Malan Borel I. Effects of isomeric fatty acids on reproductive parameters in mice. Am. J. Reprod. Immunol. 58: 487-496 (2007). *

• Veber D, Mutti E, Galmozzi E, Cedrola S, Galbiati S, Morabito A, Tredici G, La Porta CA, Scalabrino G. Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy. J. Neuroimmunol. 176: 24-33 (2006).

• Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G. Autonomic renal denervation ameliorates experimental glomerulonephritis. J. Am. Soc. Nephrol. 19: 1371-1478 (2008). *

• Veeraveedu PT, Watanabe K, Ma M, Palaniyandi SS, Yamaguchi K, Suzuki K, Kodama M, Aizawa Y. Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. Eur. J. Pharmacol. 581: 121-131 (2008).

• Velasquez-Lopera MM, Eaton VL, Lerret NM, Correa LA, Decresce RP, García LF, Jaramillo A. Induction of transplantation tolerance by allogeneic donor-derived CD4(+)CD25(+)Foxp3(+) regulatory T cells. Transpl. Immunol. 19: 127-135 (2008).

• Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, Mandrekar P, Szabo G. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology 49: 989-997 (2009). *

• Veldhoen M, Hirota K, Christensen J, O'Garra A, Stockinger B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J. Exp. Med. 206: 43-49 (2009). *

• Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189 (2006). *

• Veldhoen M, Hocking RJ, Flavell RA, Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7: 1151-1156 (2006). *

• Veldhoen M, Stockinger B. TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. Trends Immunol. 27: 358-361 (2006). *

• Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9: 1341-1346 (2008). *

• Veldman C, Nagel A, Hertl M. Type I regulatory T cells in autoimmunity and inflammatory diseases. Int. Arch. Allergy Immunol. 140: 174-183 (2006).

• Veldman C, Pahl A, Beissert S, Hansen W, Buer J, Dieckmann D, Schuler G, Hertl M. Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cells. J. Immunol. 176: 3215-3222 (2006). *

• Veldman C, Pahl A, Hertl M. Desmoglein 3-specific T regulatory 1 cells consist of two subpopulations with differential expression of the transcription factor Foxp3. Immunology 127: 40-49 (2009). *

• Veltkamp C, Sartor RB, Giese T, Autschbach F, Kaden I, Veltkamp R, Rost D, Kallinowski B, Stremmel W. Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TG{varepsilon}26 mice leading to the prevention of colitis. Gut 54: 207-214 (2005). *

• Vendetti S, Patrizio M, Riccomi A, De Magistris MT. Human CD4+ T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP. J. Leukoc. Biol. 80: 880-888 (2006). *

• Venkatraman JT, Chu WC. Effects of dietary omega3 and omega6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice. J. Nutr. Biochem. 10: 582-597 (1999). *

• Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC. The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat. Immunol. 9: 245-253 (2008). *

• Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J. Immunol. 179: 682-690 (2007). *

• Verdonk RC, Haagsma EB, Jonker MR, Bok LI, Zandvoort JH, Kleibeuker JH, Faber KN, Dijkstra G. Effects of different immunosuppressive regimens on regulatory T-cells in noninflamed colon of liver transplant recipients. Inflamm. Bowel Dis. 13: 703-709 (2007). *

• Vergani D, Mieli-Vergani G. Aetiopathogenesis of autoimmune hepatitis. World J. Gastroenterol. 14: 3306-3312 (2008). *

• Verhasselt V, Vosters O, Beuneu C, Nicaise C, Stordeur P, Goldman M. Induction of FOXP3-expressing regulatory CD4+ T cells by human mature autologous dendritic cells. Eur. J. Immunol. 34: 762-772 (2001). *

• Verrecchia F, Mauviel A, Farge D. Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmun. Rev. 5: 563-569 (2006).

• Verrecchia F, Wagner EF, Mauviel A. Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the repression of the human COL1A2 gene by TNF-alpha. EMBO Rep. 3: 1069-1074 (2002). *

• Vetrone SA, Montecino-Rodriguez E, Kudryashova E, Kramerova I, Hoffman EP, Liu SD, Miceli MC, Spencer MJ. Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta. J. Clin. Invest. 119: 1583-1594 (2009). *

• Vial P, Riquelme A, Pizarro M, Solis N, Madariaga JA, Aguayo G, Duarte I, Soza A, Accatino L, Arrese M. Pentoxifylline does not prevent neither liver damage nor early profibrogenic events in a rat model of non-alcoholic steatohepatitis. Ann. Hepatol. 5: 25-29 (2006). *

• Vieitez P, Gomez O, Uceda ER, Vera ME, Molina-Holgado E. Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy. J. Renin Angiotensin Aldosterone Syst. 9: 96-102 (2008).

• Vila J, Isaacs JD, Anderson AE. Regulatory T cells and autoimmunity. Curr. Opin. Hematol. 16: 274-279 (2009).

• Visentainer JE, Sell AM, da Silva GC, Cavichioli AD, Franceschi DS, Lieber SR, de Souza CA. TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil. Int. J. Immunogenet. 35: 287-293 (2008). *

• Vishnoi M, Pandey SN, Modi DR, Kumar A, Mittal B. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Hum. Immunol. 69: 360-367 (2008).

• Vogiatzi P, De Falco G, Claudio PP, Giordano A. How does the human RUNX3 gene induce apoptosis in gastric cancer?: latest data, reflections and reactions. Cancer Biol. Ther. 5: 371-374 (2006).

• Vojdani A, Lambert J. The role of Th17 in neuroimmune disorders: target for CAM therapy. Part I. Evid. Based Complement. Alternat. Med. Jul 21 [Epub ahead of print] (2009). *

• Vollmer S, Menssen A, Trommler P, Schendel D, Prinz JC. T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24: 2377-2382 (1994).

• Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 9: 650-657 (2008). *

• Volpe E, Touzot M, Servant N, Marloie-Provost MA, Hupe P, Barillot E, Soumelis V. Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production. Blood 114: 3610-3614 (2009). *

• von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338-344 (2005). *

• von Boehmer H. Oral tolerance: is it all retinoic acid? J. Exp. Med. 204: 1737-1739 (2007). *

• von Boyen G, Steinkamp M. The enteric glia and neurotrophic factors. Z. Gastroenterol. 44: 985-990 (2006).

• von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology 137: 361-371.e1-e5 (2009). *

• von Vietinghoff S, Ley K. IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. J. Immunol. 183: 865-873 (2009).

• Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc. Natl. Acad. Sci. U.S.A. 106: 4793-4798 (2009). *

• Vosters JL, Yin H, Roescher N, Kok MR, Tak PP, Chiorini JA. Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjogren's syndrome. Arthritis Res. Ther. 11: R189 (2009). *

• Vroling AB, Jonker MJ, Breit TM, Fokkens WJ, van Drunen CM. Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway. Allergy 63: 461-467 (2008). *

• Vural P, Degirmencioglu S, Erden S, Gelincik A. The relationship between transforming growth factor-beta1, vascular endothelial growth factor, nitric oxide and Hashimoto's thyroiditis. Int. Immunopharmacol. 9: 212-215 (2009).

• Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene 23: 2401-2407 (2004). *

• Wada Y, Hisamatsu T, Kamada N, Okamoto S, Hibi T. Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells. Inflamm. Bowel Dis. 15: 1548-1556 (2009). *

• Wagner A, Forster-Waldl E, Garner-Spitzer E, Schabussova I, Kundi M, Pollak A, Scheiner O, Joachim A, Wiedermann U. Immunoregulation by Toxoplasma gondii infection prevents allergic immune responses in mice. Int. J. Parasitol. 39: 465-472 (2009). *

• Wagner CA, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild KN, Broer S, Moschen I, Albers A, Waldegger S, Tummler B, Egan ME, Geibel JP, Kandolf R, Lang F. Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell. Physiol. Biochem. 11: 209-218 (2001).

• Wagner RD. Effects of microbiota on GI health: gnotobiotic research. Adv. Exp. Med. Biol. 635: 41-56 (2008). *

• Wahl SM. Transforming growth factor-beta: innately bipolar. Curr. Opin. Immunol. 19: 55-62 (2007).

• Wahl SM, Chen W. Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases. Arthritis Res. Ther. 7: 62-68 (2005). *

• Wahl SM, Wen J, Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol. Rev. 213: 213-227 (2006). *

• Wahl SM, Wen J, Moutsopoulos NM. The kiss of death: interrupted by NK-cell close encounters of another kind. Trends Immunol. 27: 161-164 (2006). *

• Wai PY, Kuo PC. Osteopontin: regulation in tumor metastasis. Cancer Metastasis Rev. 27: 103-118 (2008). *

• Waldmann H, Adams E, Fairchild P, Cobbold S. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol. Rev. 212: 301-313 (2006). *

• Waldmann TA. Effective cancer therapy through immunomodulation. Annu. Rev. Med. 57: 65-81 (2006). *

• Waldner MJ, Neurath MF. Cytokines in colitis associated cancer: potential drug targets? Inflamm. Allergy Drug Targets 7: 187-194 (2008).

• Walsh KP, Brady MT, Finlay CM, Boon L, Kingston HG. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J. Immunol. 183: 1577-1586 (2009).

• Walters JR. Recent findings in the cell and molecular biology of the small intestine. Curr. Opin. Gastroenterol. 21: 135-140 (2005).

• Walton KL, Makanji Y, Wilce MC, Chan KL, Robertson DM, Harrison CA. A common biosynthetic pathway governs the dimerisation and secretion of inhibin and related TGFbeta ligands. J. Biol. Chem. 284: 9311-9320 (2009). *

• Wan YY, Flavell RA. 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol. Rev. 220: 199-213 (2007). *

• Wan YY, Flavell RA. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. U.S.A. 102: 5126-5131 (2005). *

• Wang B, Morinobu A, Kanagawa S, Nakamura T, Kawano S, Koshiba M, Hashimoto H, Kumagai S. Transforming growth factor beta 1 gene polymorphism in Japanese patients with systemic lupus erythematosus. Kobe J. Med. Sci. 53: 15-23 (2007).

• Wang C, Kang SG, Lee J, Sun Z, Kim CH. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2: 173-183 (2009). *

• Wang CH, Lee WJ, Ghanta VK, Wang WT, Cheng SY, Hsueh CM. Molecules involve in the self-protection of neurons against glucose-oxygen-serum deprivation (GOSD)-induced cell damage. Brain Res. Bull. 79: 169-176 (2009).

• Wang D, Long J, Dai F, Liang M, Feng XH, Lin X. BCL6 represses Smad signaling in transforming growth factor-beta resistance. Cancer Res. 68: 783-789 (2008). *

• Wang G, Matsuura I, He D, Liu F. Transforming growth factor-beta-inducible phosphorylation of Smad3. J. Biol. Chem. 284: 9663-9673 (2009). *

• Wang GH, Tang XH, Ma YL, Gao YC. Effects of all-trans retinoic acid on the expression of TGF-beta 1 and COL-I in rat model of peritoneal dialysis. Sichuan Da Xue Xue Bao Yi Xue Ban 39: 575-578 (2008).

• Wang H, Dan Z, Jiang H. Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats. J. Huazhong Univ. Sci. Technolog. Med. Sci. 28: 553-557 (2008).

• Wang H, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, Rohrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K. TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis. J. Clin. Invest. 118: 2629-2639 (2008). *

• Wang J, Huizinga TW, Toes RE. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J. Immunol. 183: 4119-4126 (2009).

• Wang J, Leclercq I, Brymora JM, Xu N, Ramezani-Moghadam M, London RM, Brigstock D, George J. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 137: 713-723 (2009). *

• Wang J, Zhang H, Ma H, Lu B, Wang J, Li Y, Li J. Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta- intestinal intraepithelial lymphocytes. J. Nutr. Biochem. 19: 475-481 (2008). *

• Wang JY, Chuang HN, Chiu JH, Fu SL, Tsai TH, Tsou AP, Hu CP, Chi CW, Yeh SF, Lui WY, Wu CW, Chou CK. Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes. Exp. Biol. Med. (Maywood) 231: 444-455 (2006). *

• Wang L, Pino-Lagos K, de Vries VC, Guleria I, Sayegh MH, Noelle RJ. Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 105: 9331-9336 (2008). *

• Wang LY, Zeng Y, Pan ZZ, Zhu ZH. Detection of intracellular and extracellular cytokines of CD(4+)CD(25+) regulatory T cells in gastric cancer patients. Ai Zheng 26: 270-273 (2007).

• Wang M, Chen M, Zheng G, Dillard Iii B, Tallarico M, Ortiz Z, Holterman AX. Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G357-G366 (2008). *

• Wang P, Liu T, Cong M, Wu X, Bai Y, Yin C, An W, Wang B, Jia J, You H. Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta? Liver Int. 29: 575-584 (2009). *

• Wang Q, Li H, Zhang Z, Yao Y, Zhou J. Prolonged ovalbumin challenge facilitates Th17 polarization in sensitized mice. Inflamm. Res. Feb 14 [Epub ahead of print] (2010). *

• Wang Q, Liu C, Zhu F, Liu F, Zhang P, Guo C, Wang X, Li H, Ma C, Sun W, Zhang Y, Chen W, Zhang L. Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation. Mol. Immunol. Nov 10 [Epub ahead of print] (2009). *

• Wang R, Han G, Wang J, Chen G, Xu R, Wang L, Li X, Shen B, Li Y. The pathogenic role of interleukin-27 in autoimmune diabetes. Cell. Mol. Life Sci. 65: 3851-3860 (2008). *

• Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13439-13444 (2009). *

• Wang S, Jiang J, Guan Q, Lan Z, Wang H, Nguan CY, Jevnikar AM, Du C. Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model. Transpl. Immunol. 19: 93-102 (2008).

• Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J. Biol. Chem. 273: 302-308 (1998). *

• Wang SH, Chen GH, Fan Y, Van Antwerp M, Baker JR Jr. TRAIL inhibits experimental autoimmune thyroiditis by the expansion of CD4+CD25+ regulatory T cells. Endocrinology 150: 2000-2007 (2009). *

• Wang WJ, Liao B, Zeng M, Zhu C, Fan XM. The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis. Cell. Mol. Immunol. 6: 51-59 (2009). *

• Wang WM, Zhang HD, Jin YM, Zhu BB, Chen N. PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. Acta Pharmacol. Sin. 30: 107-112 (2009).

• Wang X, Allen C, Ballow M. Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-alpha from LPS-stimulated monocytes/macrophages. J. Clin. Immunol. 27: 193-200 (2007). *

• Wang X, Mosmann T. In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-gamma, and can subsequently differentiate into IL-4- or IFN-gamma-secreting cells. J. Exp. Med. 194: 1069-1080 (2001). *

• Wang XM, Chen DF. Effects of rosiglitazone on Kruppul-like factor 6(KLF6) signaling in the livers of rats with nonalcoholic fatty liver fibrosis. Zhonghua Gan Zang Bing Za Zhi 15: 649-653 (2007).

• Wang XS, Chen YY, Shang XF, Zhu ZG, Chen GQ, Han Z, Shao B, Yang HM, Xu HQ, Chen JF, Zheng RY. Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis. Brain Res. 1253: 198-209 (2009).

• Wang YF, Wei B, Ouyang Q. Expression with TGFbeta1 in the patients with ulcerative colitis. Sichuan Da Xue Xue Bao Yi Xue Ban 36: 204-206 (2005).

• Warle MC, Metselaar HJ, Hop WC, Tilanus HW. Cytokine gene polymorphisms and acute liver graft rejection: a meta-analysis. Liver Transpl. 11: 19-26 (2005). *

• Watanabe K, Sugai M, Nambu Y, Osato M, Hayashi T, Kawaguchi M, Komori T, Ito Y, Shimizu A. Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta1 and retinoic acid signaling. J. Immunol. Feb 8 [Epub ahead of print] (2010).

• Watanabe T, Wu TT, Catalano PJ, Ueki T, Satriano R, Haller DG, Benson AB 3rd, Hamilton SR. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344: 1196-1206 (2001). *

• Watanabe T, Yamori M, Kita T, Chiba T, Wakatsuki Y. CD4+CD25+ T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen. Inflamm. Bowel Dis. 11: 541-550 (2005). *

• Waters B, Qadura M, Burnett E, Chegeni R, Labelle A, Thompson P, Hough C, Lillicrap D. Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favour a Th1 response. Blood 113: 193-203 (2009). *

• Watson AJ. Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. Histol. Histopathol. 13: 591-597 (1998).

• Watt JK, Hawkins K, Zhang M, Lipschitz J, Sandha G, Gong Y, Uhanova J, Minuk GY. Transforming growth factor-beta (TGF-beta) protein levels are not elevated in the blood or bile of patients with primary sclerosing cholangitis: a pilot study. Dig. Dis. Sci. 49: 5-8 (2004). *

• Watt V, Ronchese F, Ritchie D. Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism. J. Immunother. 30: 323-332 (2007).

• Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688 (2006). *

• Weaver DJ Jr, Reis ES, Pandey MK, Kohl G, Harris N, Gerard C, Kohl J. C5a receptor-deficient dendritic cells promote induction of Treg and Th17. Eur. J. Immunol. Dec 16 [Epub ahead of print] (2009). *

• Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit. Rev. Toxicol. 33: 105-136 (2003).

• Weber MS, Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stuve O, Sobel RA, Steinman L, Zamvil SS. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 13: 935-943 (2007). *

• Weersma RK, Zhou L, Nolte IM, van der Steege G, van Dullemen HM, Oosterom E, Bok L, Peppelenbosch MP, Faber KN, Kleibeuker JH, Dijkstra G. Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5. Inflamm. Bowel Dis. 14: 1615-1622 (2008). *

• Wei BB, Xi B, Wang R, Bai JM, Chang JK, Zhang YY, Yoneda R, Su JT, Hua LX. TGFbeta1 T29C polymorphism and cancer risk: a meta-analysis based on 40 case-control studies. Cancer Genet. Cytogenet. 196: 68-75 (2010).

• Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX, Tian Z. CD4+CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J. Immunol. 181: 7221-7229 (2008). *

• Wei J, Duramad O, Perng OA, Reiner SL, Liu YJ, Qin FX. Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 104: 18169-18174 (2007). *

• Wei L, Wei-Min L, Cheng G, Bao-Guo Z. Upregulation of CD4+CD25+ T lymphocyte by adenovirus-mediated gene transfer of CTLA4Ig fusion protein in experimental autoimmune myocarditis. Autoimmunity 39: 289-298 (2006).

• Weiner HL. Immunosuppressive treatment in multiple sclerosis. J. Neurol. Sci. 223: 1-11 (2004). *

• Weinstock JV. Helminths and mucosal immune modulation. Ann. N. Y. Acad. Sci. 1072: 356-364 (2006). *

• Weinstock JV, Summers RW, Elliott DE. Role of helminths in regulating mucosal inflammation. Springer Semin. Immunopathol. 27: 249-271 (2005). *

• Weinstock-Guttman B, Bhasi K, Badgett D, Tamano-Blanco M, Minhas M, Feichter J, Patrick K, Munschauer F, Bakshi R, Ramanathan M. Genomic effects of once-weekly, intramuscular interferon-beta1a treatment after the first dose and on chronic dosing: relationships to 5-year clinical outcomes in multiple sclerosis patients. J. Neuroimmunol. 205: 113-125 (2008).

• Weiskirchen R, Meurer SK. Bone morphogenetic protein-7 in focus: a member of the transforming growth factor-beta superfamily is implicated in the maintenance of liver health. Hepatology 45: 1324-1325 (2007). *

• Welham NV, Lim X, Tateya I, Bless DM. Inflammatory factor profiles one hour following vocal fold injury. Ann. Otol. Rhinol. Laryngol. 117: 145-152 (2008).

• Wells RG. BMP-7: a new TGF-beta family member takes the stage in colitis treatment. Inflamm. Bowel Dis. 10: 169 (2004). *

• Wells RG, Kruglov E, Dranoff JA. Autocrine release of TGF-beta by portal fibroblasts regulates cell growth. FEBS Lett. 559: 107-110 (2004). *

• Weng H, Mertens PR, Gressner AM, Dooley S. IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads. J. Hepatol. 46: 295-303 (2007). *

• Weng HL, Liu Y, Chen JL, Huang T, Xu LJ, Godoy P, Hu JH, Zhou C, Stickel F, Marx A, Bohle RM, Zimmer V, Lammert F, Mueller S, Gigou M, Samuel D, Mertens PR, Singer MV, Seitz HK, Dooley S. The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis. Hepatology 50: 230-243 (2009).

• Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT. Inhibitory effects of armepavine against hepatic fibrosis in rats. J. Biomed. Sci. 16: 78 (2009). *

• Wengrower D, Zannineli G, Pappo O, Latella G, Sestieri M, Villanova A, Faitelson Y, Pines M, Goldin E. Prevention of fibrosis in experimental colitis by captopril: the role of TGF-beta1. Inflamm. Bowel Dis. 10: 536-545 (2004). *

• Werner T, Haller D. Intestinal epithelial cell signalling and chronic inflammation: from the proteome to specific molecular mechanisms. Mutat. Res. 622: 42-57 (2007).

• Westendorf AM, Fleissner D, Groebe L, Jung S, Gruber AD, Hansen W, Buer J. CD4+ Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. Gut 58: 211-219 (2009). *

• Westendorf AM, Templin M, Geffers R, Deppenmeier S, Gruber AD, Probst-Kepper M, Hansen W, Liblau RS, Gunzer F, Bruder D, Buer J. CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune regulation. Gut 54: 60-69 (2005). *

• Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, Rudnick DA. p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology 50: 207-215 (2009).

• Whiteman HJ, Farrell PJ. RUNX expression and function in human B cells. Crit. Rev. Eukaryot. Gene Expr. 16: 31-44 (2006).

• Wiedermann U, Hanson LA, Bremell T, Kahu H, Dahlgren UI. Increased translocation of Escherichia coli and development of arthritis in vitamin A-deficient rats. Infect. Immun. 63: 3062-3068 (1995). *

• Wiendl H, Hohlfeld R. Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs 16: 183-200 (2002).

• Wiendl H, Neuhaus O, Kappos L, Hohlfeld R. Multiple sclerosis. Current review of failed and discontinued clinical trials of drug treatment. Nervenarzt. 71: 597-610 (2000).

• Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, Thorikay M, ten Dijke P, Mertens PR, Breitkopf K, Dooley S. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Hepatology 43: 1032-1041 (2006). *

• Wiercinska-Drapalo A, Jaroszewicz J, Tarasow E, Flisiak R, Prokopowicz D. Transforming growth factor beta(1) and prostaglandin E2 concentrations are associated with bone formation markers in ulcerative colitis patients. Prostaglandins Other Lipid Mediat. 78: 160-168 (2005).

• Wilczynski JR. Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism? Hum. Immunol. 67: 492-511 (2006).

• Wilczynski JR, Radwan M, Kalinka J. The characterization and role of regulatory T cells in immune reactions. Front. Biosci. 13: 2266-2274 (2008).

• Wildey GM, Howe PH. Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. J. Biol. Chem. 284: 20227-20239 (2009). *

• Wildi S, Kleeff J, Maruyama H, Maurer CA, Buchler MW, Korc M. Overexpression of activin A in stage IV colorectal cancer. Gut 49: 409-417 (2001). *

• Wilfred de Alwis NM, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin. Liver Dis. 27: 44-54 (2007). *

• Will O, Carvajal-Carmona LG, Gorman P, Howarth KM, Jones AM, Polanco-Echeverry GM, Chinaleong JA, Gunther T, Silver A, Clark SK, Tomlinson I. Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. Gastroenterology 132: 527-530 (2007). *

• Williams E, Iredale J. Hepatic regeneration and TGF-beta: growing to a prosperous perfection. Gut 46: 593-594 (2000). *

• Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, Unemori EN, Iredale JP. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49: 577-583 (2001). *

• Williams JA. Receptor biology and intracellular regulatory mechanisms in pancreatic acinar cells. Curr. Opin. Gastroenterol. 18: 529-535 (2002).

• Williams RO. Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha. Methods Mol. Biol. 361: 265-284 (2006).

• Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8: 950-957 (2007). *

• Winau F, Quack C, Darmoise A, Kaufmann SH. Starring stellate cells in liver immunology. Curr. Opin. Immunol. 20: 68-74 (2008). *

• Windish HP, Lin PL, Mattila JT, Green AM, Onuoha EO, Kane LP, Flynn JL. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. J. Leukoc. Biol. 86: 713-725 (2009). *

• Winer S, Paltser G, Chan Y, Tsui H, Engleman E, Winer D, Dosch HM. Obesity predisposes to Th17 bias. Eur. J. Immunol. 39: 2629-2635 (2009). *

• Wipff PJ, Hinz B. Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. Eur. J. Cell Biol. 87: 601-615 (2008).

• Wirths O, Breyhan H, Marcello A, Cotel MC, Bruck W, Bayer TA. Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol. Aging Jul 25 [Epub ahead of print] (2008).

• Wisniewski A, Obojski A, Pawlik A, Jasek M, Luszczek W, Majorczyk E, Nowak I, Kusnierczyk P. Polymorphism of the TGFB1 gene is not associated with bronchial allergic asthma in a Polish population. Hum. Immunol. 70: 134-138 (2009).

• Wissinger E, Goulding J, Hussell T. Immune homeostasis in the respiratory tract and its impact on heterologous infection. Semin. Immunol. 21: 147-155 (2009). *

• Wohlleben G, Erb KJ. Immune stimulatory strategies for the prevention and treatment of asthma. Curr. Pharm. Des. 12: 3281-3292 (2006).

• Wolak T, Kim H, Ren Y, Kim J, Vaziri ND, Nicholas SB. Osteopontin modulates angiotensin II-induced inflammation, oxidative stress, and fibrosis of the kidney. Kidney Int. 76: 32-43 (2009). *

• Wolke C, Tadje J, Bukowska A, Tager M, Bank U, Ittenson A, Ansorge S, Lendeckel U. Assigning the phenotype of a natural regulatory T-cell to the human T-cell line, KARPAS-299. Int. J. Mol. Med. 17: 275-278 (2006). *

• Wollbold J, Huber R, Pohlers D, Koczan D, Guthke R, Kinne RW, Gausmann U. Adapted Boolean network models for extracellular matrix formation. BMC Syst. Biol. 3: 77 (2009). *

• Wood AM, Needham M, Simmonds MJ, Newby PR, Gough SC, Stockley RA. Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation. COPD 5: 353-359 (2008).

• Wood VH, O'Neil JD, Wei W, Stewart SE, Dawson CW, Young LS. Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFbeta signaling pathways. Oncogene 26: 4135-4147 (2007). *

• Woolf E, Brenner O, Goldenberg D, Levanon D, Groner Y. Runx3 regulates dendritic epidermal T cell development. Dev. Biol. 303: 703-714 (2007). *

• Woolley N, Mustalahti K, Maki M, Partanen J. Cytokine gene polymorphisms and genetic association with coeliac disease in the Finnish population. Scand. J. Immunol. 61: 51-56 (2005). *

• Wrana JL, Kubota T, Zhang Q, Overall CM, Aubin JE, Butler WT, Sodek J. Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein). Biochem. J. 273: 523-531 (1991). *

• Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-beta superfamily signaling. Cell Res. 19: 8-20 (2009). *

• Wrzesinski SH, Wan YY, Flavell RA. Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin. Cancer Res. 13: 5262-5270 (2007). *

• Wu C, Wang S, Wang F, Chen Q, Peng S, Zhang Y, Qian J, Jin J, Xu H. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin. Exp. Immunol. 158: 199-204 (2009). *

• Wu F, Qu Y, Tang Y, Cao D, Sun P, Xia Z. Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. J. Occup. Health 50: 445-454 (2008). *

• Wu GY, Hasenberg T, Magdeburg R, Bonninghoff R, Sturm JW, Keese M. Association between EGF, TGF-beta1, VEGF gene polymorphism and colorectal cancer. World J. Surg. 33: 124-129 (2009). *

• Wu HY, Center EM, Tsokos GC, Weiner HL. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus 18: 586-596 (2009). *

• Wu J, Crimmins JT, Monk KR, Williams JP, Fitzgerald ME, Tedesco S, Ratner N. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am. J. Pathol. 168: 1686-1696 (2006). *

• Wu J, Liu J, Waalkes MP, Cheng ML, Li L, Li CX, Yang Q. High dietary fat exacerbates arsenic-induced liver fibrosis in mice. Exp. Biol. Med. (Maywood) 233: 377-384 (2008). *

• Wu J, Zern MA. Hepatic stellate cells: a target for the treatment of liver fibrosis. J. Gastroenterol. 35: 665-672 (2000). *

• Wu M, Melichian DS, Chang E, Warner-Blankenship M, Ghosh AK, Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am. J. Pathol. 174: 519-533 (2009). *

• Wu PC, Fang JW, Lau VK, Lai CL, Lo CK, Lau JY. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am. J. Pathol. 149: 1167-1175 (1996).

• Wu S, Liang S, Yan Y, Wang Y, Li F, Deng Y, Huang W, Yuan W, Luo N, Zhu C, Wang Y, Li Y, Liu M, Wu X. A novel mutation of TGFbeta1 in a Chinese family with Camurati-Engelmann disease. Bone 40: 1630-1634 (2007).

• Wu T. Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. Biochim. Biophys. Acta 1755: 135-150 (2005). *

• Wu Z, Ma HM, Kukita T, Nakanishi Y, Nakanishi H. Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss. J. Immunol. Feb 22 [Epub ahead of print] (2010).

• Wynn T. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214: 199-210 (2008). *

• Wynn TA. IL-13 effector functions. Annu. Rev. Immunol. 21: 425-456 (2003). *

• Xia ZW, Zhong WW, Xu LQ, Sun JL, Shen QX, Wang JG, Shao J, Li YZ, Yu SC. Heme oxygenase-1-mediated CD4+CD25high regulatory T cells suppress allergic airway inflammation. J. Immunol. 177: 5936-5945 (2006). *

• Xian CJ, Xu X, Mardell CE, Howarth GS, Byard RW, Moore DJ, Miettinen P, Read LC. Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease. Scand. J. Gastroenterol. 34: 591-600 (1999). *

• Xiang M, Zou X, Zhang C, Zhao Z, Xu J. Insulin administration confers diabetes-preventive properties to NOD mice derived dendritic cells. Immunopharmacol. Immunotoxicol. 29: 451-464 (2007).

• Xiang Y, Matsui T, Matsuo K, Shimada K, Tohma S, Nakamura H, Masuko K, Yudoh K, Nishioka K, Kato T. Comprehensive investigation of disease-specific short peptides in sera from patients with systemic sclerosis: complement C3f-des-arginine, detected predominantly in systemic sclerosis sera, enhances proliferation of vascular endothelial cells. Arthritis Rheum. 56: 2018-2030 (2007). *

• Xiao BG, Zhu WH, Lu CZ. The presence of GM-CSF and IL-4 interferes with effect of TGF-beta1 on antigen presenting cells in patients with multiple sclerosis and in rats with experimental autoimmune encephalomyelitis. Cell. Immunol. 249: 30-36 (2007). *

• Xiao L, Cheng J, Guo H, Hong Y, Zhang LY, Zhang YX, Zhang JL, Li Y. A study on differentially expressed genes in hepatic stellate cells treated with transforming growth factor beta 1 using cDNA microarray technique. Zhonghua Gan Zang Bing Za Zhi 16: 752-756 (2008).

• Xiao M, Wang C, Zhang J, Li Z, Zhao X, Qin Z. IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res. 69: 2010-2017 (2009). *

• Xiao R, Kanekura T, Yoshida N, Higashi Y, Yan KL, Fukushige T, Kanzaki T. 9-cis-Retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E(2) production in scleroderma fibroblasts. Clin. Exp. Dermatol. 33: 484-490 (2008). *

• Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, Kuchroo VK. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J. Immunol. 181: 2277-2284 (2008). *

• Xie HY, Wang WL, Yao MY, Yu SF, Feng XN, Jin J, Jiang ZJ, Wu LM, Zheng SS. Polymorphisms in cytokine genes and their association with acute rejection and recurrence of hepatitis B in Chinese liver transplant recipients. Arch. Med. Res. 39: 420-428 (2008).

• Xie JJ, Wang J, Tang TT, Chen J, Gao XL, Yuan J, Zhou ZH, Liao MY, Yao R, Yu X, Wang D, Cheng Y, Liao YH, Cheng X. The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice Th17/Treg imbalance in atherogenesis. Cytokine Oct 14 [Epub ahead of print] (2009).

• Xie L, Li XK, Funeshima-Fuji N, Kimura H, Matsumoto Y, Isaka Y, Takahara S. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int. Immunopharmacol. 9: 575-581 (2009).

• Xiong DH, Liu XG, Guo YF, Tan LJ, Wang L, Sha BY, Tang ZH, Pan F, Yang TL, Chen XD, Lei SF, Yerges LM, Zhu XZ, Wheeler VW, Patrick AL, Bunker CH, Guo Y, Yan H, Pei YF, Zhang YP, Levy S, Papasian CJ, Xiao P, Lundberg YW, Recker RR, Liu YZ, Liu YJ, et al. Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am. J. Hum. Genet. 84: 388-398 (2009). *

• Xiong M, Arnett FC, Guo X, Xiong H, Zhou X. Differential dynamic properties of scleroderma fibroblasts in response to perturbation of environmental stimuli. PLoS ONE 3: e1693 (2008). *

• Xiong XZ, Jin Y, Zhou Q, Zhang XJ, Du W, Liu W, Huang SA. Correlation between FoxP3(+) regulatory T cells and chronic obstructive pulmonary disease. Zhonghua Yi Xue Za Zhi 88: 471-474 (2008).

• Xu J, Yang Y, Qiu G, Lal G, Wu Z, Levy DE, Ochando JC, Bromberg JS, Ding Y. c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 182: 6226-6236 (2009).

• Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4(+)CD25(-)Foxp3(-) T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178: 6725-6729 (2007). *

• Xu Q, Hendry BM, Maden M, Lu H, Wong YF, Rankin AC, Noor M, Kopp JB. Kidneys of Alb/TGF-beta(1) transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity. Nephron. Exp. Nephrol. 114: e127-e132 (2010).

• Xu R, Wang R, Han G, Wang J, Chen G, Wang L, Li X, Guo R, Shen B, Li Y. Complement C5a regulates interleukin-17 by affecting the crosstalk between DCs and gammadelta T cells in CLP-induced sepsis. Eur. J. Immunol. Feb 5 [Epub ahead of print] (2010). *

• Xu Y, Pasche B. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum. Mol. Genet. 16 Spec. No. 1: R14-R20 (2007). *

• Xu ZJ, Fan JG, Ding XD, Qiao L, Wang GL. Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats. Dig. Dis. Sci. May 21 [Epub ahead of print] (2009). *

• Xue Q, Luan X, Gu Y, Wu H, Zhang G, Yu G, Zhu H, Wang M, Dong W, Geng YJ, Zhang X. The negative co-signaling molecule B7-H4 is expressed by human BMSC and mediates its T cell modulatory activity. Stem Cells Dev. Sep 29 [Epub ahead of print] (2009).

• Yadav M, Rosenbaum J, Goetzl EJ. Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. J. Immunol. 180: 2772-2776 (2008). *

• Yagi Y, Andoh A, Ogawa A, Bamba S, Tsujikawa T, Sasaki M, Mitsuyama K, Fujiyama Y. Microarray analysis of leukocytapheresis-induced changes in gene expression patterns of peripheral blood mononuclear cells in patients with ulcerative colitis. Ther. Apher. Dial. 11: 331-336 (2007).

• Yalniz M, Bahcecioglu IH, Kuzu N, Poyrazoglu OK, Bulmus O, Celebi S, Ustundag B, Ozercan IH, Sahin K. Preventive role of genistein in an experimental non-alcoholic steatohepatitis model. J. Gastroenterol. Hepatol. 22: 2009-2014 (2007). *

• Yamada H, Watanabe M, Nanba T, Akamizu T, Iwatani Y. The +869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. Clin. Exp. Immunol. 151: 379-382 (2008). *

• Yamaguchi T, Miyashita C, Koyano S, Kanda H, Yoshioka K, Shiba T, Takamatsu N, Ito M. JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1. Cell Biol. Int. 33: 364-368 (2009).

• Yamamoto H, Ito K, Kawai M, Murakami Y, Bessho K, Ito Y. Runx3 expression during mouse tongue and palate development. Anat. Rec. A. Discov. Mol. Cell. Evol. Biol. 288: 695-699 (2006).

• Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J. Immunol. 160: 2188-2196 (1998). *

• Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S. Cutting edge: pivotal function of Ubc13 in thymocyte TCR signaling. J. Immunol. 177: 7520-7524 (2006). *

• Yamamoto M, Yamauchi T, Okano K, Takahashi M, Watabe S, Yamamoto Y. Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. Tohoku J. Exp. Med. 217: 193-201 (2009). *

• Yamasaki S, Kurita N, Hata J, Moritani M, Itakura M, Shimada M. The effect of transgenic expression of TGF-beta1 on transplanted islet graft survival. Hepatogastroenterology 54: 1617-1621 (2007).

• Yamazaki S, Dudziak D, Heidkamp GF, Fiorese C, Bonito AJ, Inaba K, Nussenzweig MC, Steinman RM. CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J. Immunol. 181: 6923-6933 (2008). *

• Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C. CCR6 regulates the migration of inflammatory and regulatory T cells. J. Immunol. 181: 8391-8401 (2008). *

• Yan B, Chen G, Saigal K, Yang X, Jensen ST, Van Waes C, Stoeckert CJ, Chen Z. Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancers differing in p53 status. Genome Biol. 9: R53 (2008). *

• Yan C, Boyd DD. Regulation of matrix metalloproteinase gene expression. J. Cell. Physiol. 211: 19-26 (2007). *

• Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc. Natl. Acad. Sci. U.S.A. 101: 17468-17473 (2004). *

• Yan X, Liu Z, Chen Y. Regulation of TGF-beta signaling by Smad7. Acta Biochim. Biophys. Sin. (Shanghai) 41: 263-272 (2009).

• Yang FC, Chen S, Clegg T, Li X, Morgan T, Estwick SA, Yuan J, Khalaf W, Burgin S, Travers J, Parada LF, Ingram DA, Clapp DW. Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Hum. Mol. Genet. 15: 2421-2437 (2006). *

• Yang GX, Lian ZX, Chuang YH, Moritoki Y, Lan RY, Wakabayashi K, Ansari AA, Flavell RA, Ridgway WM, Coppel RL, Tsuneyama K, Mackay IR, Gershwin ME. Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology 47: 1974-1982 (2008). *

• Yang J, Jia L, Li L, Wu CY. The differentiation and regulation of antigen-specific Th17 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 213-216 (2008).

• Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J. Autoimmun. 32: 94-103 (2009).

• Yang KL, Chang WT, Chuang CC, Hung KC, Li EI. Antagonizing TGF-beta induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx. Biochem. Biophys. Res. Commun. 365: 484-489 (2008). *

• Yang KL, Chang WT, Hung KC, Li EI, Chuang CC. Inhibition of transforming growth factor-beta-induced liver fibrosis by a retinoic acid derivative via the suppression of Col 1A2 promoter activity. Biochem. Biophys. Res. Commun. 373: 219-223 (2008). *

• Yang KL, Hung KC, Chang WT, Li EI. Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene. Comp. Hepatol. 6: 9 (2007). *

• Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454: 350-352 (2008). *

• Yang L, Bataller R, Dulyx J, Coffman TM, Gines P, Rippe RA, Brenner DA. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J. Hepatol. 43: 317-323 (2005). *

• Yang S, Mu HQ, Zhang L, Chen YH. Efficacy of interleukin-10 for experimental autoimmune prostatitis. Zhonghua Nan Ke Xue 15: 1085-1089 (2009).

• Yang SH, Jin JZ, Lee SH, Park H, Kim CH, Lee DS, Kim S, Chung NH, Kim YS. Role of NKT cells in allogeneic islet graft survival. Clin. Immunol. 124: 258-266 (2007). *

• Yang X, Guo M, Wan YJ. Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers. Am. J. Pathol. Dec 24 [Epub ahead of print] (2009). *

• Yang X, Yip J, Anastassiades T, Harrison M, Brockhausen I. The action of TNFalpha and TGFbeta include specific alterations of the glycosylation of bovine and human chondrocytes. Biochim. Biophys. Acta 1773: 264-272 (2007). *

• Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29: 44-56 (2008). *

• Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORalpha and RORgamma. Immunity 28: 29-39 (2008). *

• Yang Y, Weiner J, Liu Y, Smith AJ, Huss DJ, Winger R, Peng H, Cravens PD, Racke MK, Lovett-Racke AE. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 206: 1549-1564 (2009). *

• Yang Y, Xu J, Niu Y, Bromberg JS, Ding Y. T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J. Immunol. 181: 8700-8710 (2008). *

• Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Bottinger EP. Hierarchical model of gene regulation by transforming growth factor beta. Proc. Natl. Acad. Sci. U.S.A. 100: 10269-10274 (2003). *

• Yang YY, Huang YT, Lee KC, Lee FY, Lee TY, Hou MC, Lin HC, Lee SD. Chronic administration of ursodeoxycholic acid decreases portal pressure in rats with biliary cirrhosis. Clin. Sci. (Lond.) 116: 71-79 (2009). *

• Yano T, Ito K, Fukamachi H, Chi XZ, Wee HJ, Inoue K, Ida H, Bouillet P, Strasser A, Bae SC, Ito Y. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol. Cell. Biol. 26: 4474-4488 (2006). *

• Yao Q, Pawlaczyk K, Ayala ER, Kuzlan M, Styszynski A, Breborowicz A, Heimburger O, Qian J, Stenvinkel P, Axelsson J, Lindholm B. Peroxisome proliferator-activated receptor-gamma agonists diminish peritoneal functional and morphological changes induced by bioincompatible peritoneal dialysis solution. Blood Purif. 24: 575-582 (2006).

• Yao Y, Zou R, Liu X, Jiang J, Huang Q, He Y, Li M, Wang S, Zhou J, Ma D, Xu G. Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma. J. Huazhong Univ. Sci. Technolog. Med. Sci. 28: 543-548 (2008).

• Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF. Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J. Biol. Chem. 283: 9917-9924 (2008). *

• Yasuda M, Ito T, Oono T, Kawabe K, Kaku T, Igarashi H, Nakamura T, Takayanagi R. Fractalkine and TGF-beta1 levels reflect the severity of chronic pancreatitis in humans. World J. Gastroenterol. 14: 6488-6495 (2008). *

• Yayi H, Danqing W, Shuyun L, Jicheng L. Immunologic abnormality of intrahepatic cholestasis of pregnancy. Am. J. Reprod. Immunol. Jan 10 [Epub ahead of print] (2010). *

• Yeh TS, Ho YP, Huang SF, Yeh JN, Jan YY, Chen MF. Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats. J. Hepatol. 41: 606-612 (2004). *

• Yessoufou A, Ple A, Moutairou K, Hichami A, Khan NA. Docosahexaenoic acid reduces suppressive and migratory functions of CD4CD25 regulatory T-cells. J. Lipid Res. 50: 2377-2388 (2009). *

• Yi HF, Zhen Y, Jiang LL, Zheng JL, Zhao Y. The phenotypic characterization of naturally occurring regulatory CD4(+)CD25(+) T cells. Cell. Mol. Immunol. 3: 189-195 (2006). *

• Yi HJ, Chae CS, So JS, Tzartos SJ, Souroujon MC, Fuchs S, Im SH. Suppression of experimental myasthenia gravis by a B-cell epitope-free recombinant acetylcholine receptor. Mol. Immunol. 46: 192-201 (2009). *

• Yip YL, Tsao SW. Regulation of p63 expression in primary and immortalized nasopharyngeal epithelial cells. Int. J. Oncol. 33: 713-724 (2008). *

• Yiu WH, Pan CJ, Ruef RA, Peng WT, Starost MF, Mansfield BC, Chou JY. Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia. Kidney Int. 73: 716-723 (2008). *

• Yogesha SD, Khapli SM, Srivastava RK, Mangashetti LS, Pote ST, Mishra GC, Wani MR. IL-3 Inhibits TNF-alpha-induced bone resorption and prevents inflammatory arthritis. J. Immunol. 182: 361-370 (2009). *

• Yokohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K, Hasegawa T, Tokusashi Y, Miyokawa N, Nakamura K. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology 40: 1222-1225 (2004). *

• Yong Z, Chang L, Mei YX, Yi L. Role and mechanisms of CD4(+)CD25(+) regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl. Immunol. 17: 120-129 (2007).

• Yoo BM, Yeo M, Oh TY, Choi JH, Kim WW, Kim JH, Cho SW, Kim SJ, Hahm KB. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 30: e71-e79 (2005).

• Yoo KH, Kim YN, Lee MJ, Seong JK, Park JH. Identification of apolipoproteinA1 reduction in the polycystic kidney by proteomics analysis of the Mxi1-deficient mouse. Proteomics 9: 3824-3832 (2009). *

• Yoon JS, Kim JY, Park HK, Kim ES, Ahn KS, Yoon SS, Cho CG, Kim BK, Lee YY. Antileukemic effect of a synthetic vitamin D3 analog, HY-11, with low potential to cause hypercalcemia. Int. J. Oncol. 32: 387-396 (2008). *

• Yoshida K, Yang GX, Zhang W, Tsuda M, Tsuneyama K, Moritoki Y, Ansari AA, Okazaki K, Lian ZX, Coppel RL, Mackay IR, Gershwin ME. Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology 50: 1494-1500 (2009). *

• Yoshida S. What can we learn from molecular genetic analyses of inherited eye diseases? Nippon Ganka Gakkai Zasshi 110: 898-913 (2006).

• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y. Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors. Int. J. Mol. Med. 23: 785-792 (2009).

• Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S. CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. Am. J. Pathol. 172: 1650-1663 (2008). *

• Yoshizaki K. A new therapeutic strategy for autoimmune and chronic inflammatory disease based on clinical results using IL-6 blocking therapy with a humanized anti-IL-6 receptor antibody. Yakugaku Zasshi 129: 667-674 (2009).

• You S, Alyanakian MA, Segovia B, Damotte D, Bluestone J, Bach JF, Chatenoud L. Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Ann. N. Y. Acad. Sci. 1150: 300-310 (2008). *

• You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc. Natl. Acad. Sci. U.S.A. 104: 6335-6340 (2007). *

• You S, Thieblemont N, Alyanakian MA, Bach JF, Chatenoud L. Transforming growth factor-beta and T-cell-mediated immunoregulation in the control of autoimmune diabetes. Immunol. Rev. 212: 185-202 (2006). *

• Young NT, Waller EC, Patel R, Roghanian A, Austyn JM, Trowsdale J. The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells. Blood 111: 3090-3096 (2008). *

• Yovchev MI, Zhang J, Neufeld DS, Grozdanov PN, Dabeva MD. Thymus cell antigen-1-expressing cells in the oval cell compartment. Hepatology 50: 601-611 (2009).

• Yu C, Azuma A, Li Y, Wang C, Abe S, Usuki J, Matsuda K, Kudoh S, Sunazuka T, Omura S. EM703, a new derivative of erythromycin, inhibits transforming growth factor-beta signaling in human lung fibroblasts. Exp. Lung Res. 34: 343-354 (2008).

• Yu F, Chou CW, Chen CC. TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65. Cell. Signal. 21: 867-872 (2009).

• Yu H, Mrowietz U, Seifert O. Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin. Acta Derm. Venereol. 89: 351-356 (2009).

• Yu JH, Kim KH, Kim H. SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. Int. J. Biochem. Cell Biol. 40: 677-688 (2008). *

• Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J. Phosphorylation of Thr178 and Thr184 inTAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappa B and AP-1 activation as well as IL-6 gene expression. J. Biol. Chem. 283: 24497-24505 (2008). *

• Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 106: 7985-7990 (2009). *

• Yuan W, Collado-Hidalgo A, Yufit T, Taylor M, Varga J. Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-beta: selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression. J. Cell. Physiol. 177: 174-186 (1998).

• Yue HY, Yin C, Hou JL, Zeng X, Chen YX, Zhong W, Hu PF, Deng X, Zhang JP, Ning BF, Shi J, Zhang X, Lin Y, Xie WF. Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats. Gut 59: 236-246 (2010). *

• Yuhua Z, Wanhua R, Chenggang S, Jun S, Yanjun W, Chunqing Z. Disruption of connective tissue growth factor by short hairpin RNA inhibits collagen synthesis and extracellular matrix secretion in hepatic stellate cells. Liver Int. 28: 632-639 (2008). *

• Zachou K, Rigopoulou EI, Tsikrikoni A, Alexandrakis MG, Passam F, Kyriakou DS, Stathakis NE, Dalekos GN. Autoimmune hepatitis type 1 and primary biliary cirrhosis have distinct bone marrow cytokine production. J. Autoimmun. 25: 283-288 (2005).

• Zager RA, Johnson AC, Lund S. Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury. Am. J. Physiol. Renal Physiol. 297: F961-F970 (2009). *

• Zaher H, Shaker OG, El-Komy MH, El-Tawdi A, Fawzi M, Kadry D. Serum and tissue expression of transforming growth factor beta 1 in psoriasis. J. Eur. Acad. Dermatol. Venereol. 23: 406-409 (2009).

• Zak S, Treven J, Nash N, Gutierrez LS. Lack of thrombospondin-1 increases angiogenesis in a model of chronic inflammatory bowel disease. Int. J. Colorectal Dis. 23: 297-304 (2008). *

• Zang W, Lin M, Kalache S, Zhang N, Kruger B, Waaga-Gasser AM, Grimm M, Hancock W, Heeger P, Schroppel B, Murphy B. Inhibition of the alloimmune response through the generation of regulatory T cells by a MHC class II-derived peptide. J. Immunol. 181: 7499-7506 (2008).

• Zarate-Blades CR, Bonato VL, da Silveira EL, E Paula MO, Junta CM, Sandrin-Garcia P, Fachin AL, Mello SS, Cardoso RS, de Sa Galetti FC, Coelho-Castelo AA, Ramos SG, Donadi EA, Sakamoto-Hojo ET, da Silva Passos GA, Silva CL. Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy. J. Gene Med. 11: 66-78 (2009).

• Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, Drake CG, Powell JD. A2A receptor signaling promotes peripheral tolerance by inducing T cell anergy and the generation of adaptive regulatory T cells. Blood 111: 251-259 (2008). *

• Zauberman A, Lapter S, Zipori D. Smad proteins suppress CCAAT/enhancer-binding protein (C/EBP) beta- and STAT3-mediated transcriptional activation of the haptoglobin promoter. J. Biol. Chem. 276: 24719-24725 (2001).

• Zemtsov A, Montalvo-Lugo V. Topically applied growth factors change skin cytoplasmic creatine kinase activity and distribution and produce abnormal keratinocyte differentiation in murine skin. Skin Res. Technol. 14: 370-375 (2008).

• Zen Y, Fujii T, Harada K, Kawano M, Yamada K, Takahira M, Nakanuma Y. Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology 45: 1538-1546 (2007). *

• Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK. Anti-metastatic role of Smad4 signaling in colorectal cancer. Gastroenterology Nov 9 [Epub ahead of print] (2009). *

• Zhang CH, Wen ZQ, Li JF, Li CZ, Shi M, Yang GW, Lan SM, Zhu Y, Wang F, Zhang YJ, Wang YY, Zhang H. Inhibition of proliferation and transforming growth factor beta3 protein expression by peroxisome proliferators-activated receptor gamma ligands in human uterine leiomyoma cells. Chin. Med. J. (Engl.) 121: 166-171 (2008). *

• Zhang GY, Cheng T, Zheng MH, Yi CG, Pan H, Li ZJ, Chen XL, Yu Q, Jiang LF, Zhou FY, Li XY, Yang JQ, Chu TG, Gao WY. Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. Arch. Dermatol. Res. 301: 515-522 (2009). *

• Zhang GY, Cheng T, Zheng MH, Yi CG, Pan H, Li ZJ, Chen XL, Yu Q, Jiang LF, Zhou FY, Li XY, Yang JQ, Chu TG, Gao WY. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts. J. Plast. Reconstr. Aesthet. Surg. Jul 17 [Epub ahead of print] (2009).

• Zhang GY, Yi CG, Li X, Ma B, Li ZJ, Chen XL, Guo SZ, Gao WY. Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts. Br. J. Dermatol. 160: 762-770 (2009). *

• Zhang H, Li N, Tang Y, Wu W, Zhang Q, Yu Z. Negative functional interaction of retinoic acid and TGF-beta signaling mediated by TG-interacting factor during chondrogenesis. Cell. Physiol. Biochem. 23: 157-164 (2009).

• Zhang L, Bertucci AM, Ramsey-Goldman R, Burt RK, Datta SK. Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus. J. Immunol. 183: 6346-6358 (2009).

• Zhang L, Yi H, Xia XP, Zhao Y. Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune tolerance. Autoimmunity 39: 269-276 (2006).

• Zhang L, Zhao Y. The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road. J. Cell. Physiol. 211: 590-597 (2007). *

• Zhang M, Hagiwara S, Matsumoto M, Gu L, Tanimoto M, Nakamura S, Kaneko S, Gohda T, Qian J, Horikoshi S, Tomino Y. Effects of eicosapentaenoic acid on the early stage of type 2 diabetic nephropathy in KKA(y)/Ta mice: involvement of anti-inflammation and antioxidative stress. Metabolism 55: 1590-1598 (2006). *

• Zhang N, Kruger B, Lal G, Luan Y, Yadav A, Zang W, Grimm M, Waaga-Gasser AM, Murphy B, Bromberg JS, Schroppel B. Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival. Immunol. Lett. Oct 28 [Epub ahead of print] (2009).

• Zhang N, Schroppel B, Lal G, Jakubzick C, Mao X, Chen D, Yin N, Jessberger R, Ochando JC, Ding Y, Bromberg JS. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30: 458-469 (2009). *

• Zhang RW, Supowit SC, Xu X, Li H, Christensen MD, Lozano R, Simmons DJ. Expression of selected osteogenic markers in the fibroblast-like cells of rat marrow stroma. Calcif. Tissue Int. 56: 283-291 (1995).

• Zhang W, Jin H, Hu Y, Yu Y, Li X, Ding Z, Kang Y, Wang B. Protective response against type 1 diabetes in NOD mice after co-immunization of insulin and DNA encoding pro-insulin. Hum Gene Ther. Sep 29 [Epub ahead of print] (2009).

• Zhang W, Luo FJ, Zhou JJ, Zhang WL. Research progress on Th17 cells. Zhejiang Da Xue Xue Bao Yi Xue Ban 36: 620-625 (2007).

• Zhang W, Moritoki Y, Tsuneyama K, Yang GX, Ilan Y, Lian ZX, Gershwin ME. Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis. Clin. Exp. Immunol. 157: 359-364 (2009). *

• Zhang XL, Peng J, Sun JZ, Liu JJ, Guo CS, Wang ZG, Yu Y, Shi Y, Qin P, Li SG, Zhang LN, Hou M. De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25- cells in patients with idiopathic thrombocytopenic purpura. Blood 113: 2568-2577 (2009). *

• Zhang Y, Ikegami T, Miyazaki T, Honda A, Rojkind M, Bouscarel B, Matsuzaki Y. Bile acids enhance cellular motility of the hepatic myofibroblast-like cell through the regulation of p38/JNK signaling. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 73 (2006). *

• Zhang Y, McCormick LL, Desai SR, Wu C, Gilliam AC. Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. J. Immunol. 168: 3088-3098 (2002). *

• Zhang Y, McCormick LL, Gilliam AC. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J. Invest. Dermatol. 121: 713-719 (2003). *

• Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J. Neurosci. 26: 12174-12185 (2006). *

• Zhang Z, Sun L, Wang Y, Ning G, Minto AW, Kong J, Quigg RJ, Li YC. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 73: 163-171 (2008). *

• Zhao CB, Coons SW, Cui M, Shi FD, Vollmer TL, Ma CY, Kuniyoshi SM, Shi J. A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin. Biochem. Biophys. Res. Commun. 370: 16-21 (2008). *

• Zhao HF, Ito T, Gibo J, Kawabe K, Oono T, Kaku T, Arita Y, Zhao QW, Usui M, Egashira K, Nawata H. Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats. Gut 54: 1759-1767 (2005). *

• Zhao L, Jiang S, Hantash BM. TGF-beta1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng. Part A. Sep 21. [Epub ahead of print] (2009).

• Zhao W, Wang Y, Wang D, Sun B, Wang G, Wang J, Kong Q, Wang Q, Peng H, Jin L, Li H. TGF-beta expression by allogeneic bone marrow stromal cells ameliorates diabetes in NOD mice through modulating the distribution of CD4+ T cell subsets. Cell. Immunol. 253: 23-30 (2008). *

• Zhao Z, Yu S, Fitzgerald DC, Elbehi M, Ciric B, Rostami AM, Zhang GX. IL-12Rbeta2 promotes the development of CD4+CD25+ regulatory T cells. J. Immunol. 181: 3870-3876 (2008). *

• Zheng S, Chen A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G113-G123 (2007). *

• Zheng SG. The critical role of TGF-beta1 in the development of induced Foxp3+ regulatory T cells. Int. J. Clin. Exp. Med. 1: 192-202 (2008). *

• Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 180: 7112-7116 (2008). *

• Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 178: 2018-2027 (2007). *

• Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol. 172: 5213-5221 (2004). *

• Zheng SG, Wang JH, Stohl W, Kim KS, Gray JD, Horwitz DA. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 176: 3321-3329 (2006). *

• Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J. Cell Physiol. 222: 95-102 (2010).

• Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotes Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest. Ophthalmol. Vis. Sci. Feb 3 [Epub ahead of print] (2010).

• Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J, Ouyang W. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651 (2007). *

• Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature Jan 13 [Epub ahead of print] (2010). *

• Zhong W, Shen WF, Ning BF, Hu PF, Lin Y, Yue HY, Yin C, Hou JL, Chen YX, Zhang JP, Zhang X, Xie WF. Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats. Hepatology 50: 1524-1536 (2009).

• Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB, Rothstein TL. Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur. J. Immunol. 37: 2400-2404 (2007). *

• Zhou H, Hammonds RG Jr, Findlay DM, Martin TJ, Ng KW. Differential effects of transforming growth factor-beta 1 and bone morphogenetic protein 4 on gene expression and differentiated function of preosteoblasts. J. Cell. Physiol. 155: 112-119 (1993).

• Zhou H, Manji SS, Findlay DM, Martin TJ, Heath JK, Ng KW. Novel action of retinoic acid. Stabilization of newly synthesized alkaline phosphatase transcripts. J. Biol. Chem. 269: 22433-22439 (1994). *

• Zhou K, Zhang H, Jin O, Feng X, Yao G, Hou Y, Sun L. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cell. Mol. Immunol. 5: 417-424 (2008). *

• Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974 (2007). *

• Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453: 236-240 (2008). *

• Zhou P, Borojevic R, Streutker C, Snider D, Liang H, Croitoru K. Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J. Immunol. 172: 1515-1523 (2004). *

• Zhou X, Chen W, Swartz MD, Lu Y, Yu R, Amos CI, Wu CC, Shete S. Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data. BMC Proc. 1 Suppl. 1: S53 (2007). *

• Zhou X, Johnston TP, Johansson D, Parini P, Funa K, Svensson J, Hansson GK. Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice. Atherosclerosis 204: 381-387 (2009).

• Zhou X, Tan FK, Guo X, Wallis D, Milewicz DM, Xue S, Arnett FC. Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts. Arthritis Rheum. 52: 257-261 (2005). *

• Zhou X, Tan FK, Stivers DN, Arnett FC. Microsatellites and intragenic polymorphisms of transforming growth factor beta and platelet-derived growth factor and their receptor genes in Native Americans with systemic sclerosis (scleroderma): a preliminary analysis showing no genetic association. Arthritis Rheum. 43: 1068-1073 (2000). *

• Zhou Y, Tang ZL, Wei GL, Wang H, Ye SC, Chen KQ, Chen YH, Liu RH. Effects of nuclear factor-kappa B p65 ASODN on transforming growth beta-1 and intercellular adhesion molecule-1 of rat hepatic stellate cells. Zhonghua Gan Zang Bing Za Zhi 16: 762-766 (2008).

• Zhu BQ, Song-Wen J, Yong-Qian S. CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses. Biomed. Pharmacother. 63: 509-516 (2009).

• Zhu H, Bona C, McGaha TL. Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice. Autoimmunity 37: 51-55 (2004).

• Zhu J, Davidson TS, Wei G, Jankovic D, Cui K, Schones DE, Guo L, Zhao K, Shevach EM, Paul WE. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J. Exp. Med. 206: 329-341 (2009). *

• Ziegler SF, Buckner JH. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 11: 594-598 (2009). *

• Zimmerli SC, Hauser C. Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1. J. Invest. Dermatol. 127: 2381-2390 (2007). *

• Zimmermann A. Regulation of liver regeneration. Nephrol. Dial. Transplant. 19 Suppl. 4: IV6-IV10 (2004). *

• Zimmermann RP, Feil G, Bock C, Hoeltl L, Stenzl A. Significant alterations of serum cytokine levels in patients with Peyronie's disease. Int. Braz. J. Urol. 34: 457-466 (2008). *

• Zindy PJ, L'helgoualc'h A, Bonnier D, Le Bechec A, Bourd-Boitin K, Zhang CX, Musso O, Glaise D, Berangere Troadec M, Loreal O, Turlin B, Leger J, Clement B, Theret N. Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis. Hepatology 44: 1296-1307 (2006). *

• Zoja C, Corna D, Rottoli D, Zanchi C, Abbate M, Remuzzi G. Imatinib ameliorates renal disease and survival in murine lupus autoimmune disease. Kidney Int. 70: 97-103 (2006). *

• Zuberi RI, Ge XN, Jiang S, Bahaie NS, Kang BN, Hosseinkhani RM, Frenzel EM, Fuster MM, Esko JD, Rao SP, Sriramarao P. Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation. J. Immunol. 183: 3971-3979 (2009).

• Zwirner NW, Fuertes MB, Girart MV, Domaica CI, Rossi LE. Cytokine-driven regulation of NK cell functions in tumor immunity: role of the MICA-NKG2D system. Cytokine Growth Factor Rev. 18: 159-170 (2007).

Number of references = 2587

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