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Scientific Literature, RXR
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Aarnisalo P, Kim CH, Lee JW, Perlmann T. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.
J. Biol. Chem. 277: 35118-35123 (2002).
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Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Zhang Y, Hill J, Bissonnette RP, Medina D, Brown PH, Aldaz CM. Transcriptomic signature of the chemopreventive bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models.
BMC Med. Genomics 1: 40 (2008).
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Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P, Petkovich M. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.
J. Biol. Chem. 273: 2409-2415 (1998).
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Adachi S, Okuno M, Matsushima-Nishiwaki R, Takano Y, Kojima S, Friedman SL, Moriwaki H, Okano Y. Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma.
Hepatology 35: 332-340 (2002).
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Adachi T, Nakagawa H, Hagiya Y, Yasuoka T, Ishikawa T. Transport-metabolism interplay: LXR-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Mol. Pharm. 6: 1678-1688 (2009).
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Adam-Stitah S, Penna L, Chambon P, Rochette-Egly C. Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.
J. Biol. Chem. 274: 18932-18941 (1999).
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Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response.
J. Bone Miner. Res. 22 Suppl. 2: V20-V24 (2007).
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Agassandian M, Miakotina OL, Andrews M, Mathur SN, Mallampalli RK. P. aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha/RXR.
Biochem. J. 403: 409-420 (2007).
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Aggarwal S, Kim SW, Cheon K, Tabassam FH, Yoon JH, Koo JS. Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells.
Mol. Biol. Cell. 17: 566-575 (2006).
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Ahmed RA, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T. Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes.
Endocrine 35: 233-242 (2009).
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Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, Abnet CC, Huang WY, Kibel AS, Crawford ED, Weinstein SJ, Chanock SJ, Schatzkin A, Hayes RB; for the Prostate, Lung, Colorectal, and Ovarian (PLCO) Trial Project Team. Vitamin D-related genes, serum vitamin D concentrations, and prostate cancer risk.
Carcinogenesis 30: 769-776 (2009).
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Ahuja HS, Szanto A, Nagy L, Davies PJ. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death.
J. Biol. Regul. Homeost. Agents 17: 29-45 (2003).
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Akanuma SI, Hori S, Ohtsuki S, Fujiyoshi M, Terasaki T. Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier.
Neurochem. Int. 52: 669-674 (2008).
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Akiyama TE, Baumann CT, Sakai S, Hager GL, Gonzalez FJ. Selective intranuclear redistribution of PPAR isoforms by RXR alpha.
Mol. Endocrinol. 16: 707-721 (2002).
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Albalat R, Canestro C. Identification of Aldh1a, Cyp26 and RAR orthologs in protostomes pushes back the retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor.
Chem. Biol. Interact. 178: 188-196 (2009).
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Aleksunes LM, Yeager RL, Klaassen CD. Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.
Xenobiotica 39: 514-522 (2009).
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Aleman G, Torres N, Tovar AR. Peroxisome proliferator-activated receptors (PPARs) in obesity and insulin resistance development.
Rev. Invest. Clin. 56: 351-367 (2004).
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Ali FY, Davidson SJ, Moraes LA, Traves SL, Paul-Clark M, Bishop-Bailey D, Warner TD, Mitchell JA. Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta.
FASEB J. 20: 326-328 (2006).
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Ali-Khan SE, Hales BF. Retinoid receptor antagonists alter the pattern of apoptosis in organogenesis stage mouse limbs.
Toxicol. Sci. 90: 208-220 (2006).
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Alique M, Herrero JF, Lucio-Cazana FJ. All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2.
J. Neuroinflammation 4: 1 (2007).
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Alique M, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.
Br. J. Pharmacol. 149: 65-72 (2006).
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Alique M, Lucio-Cazana FJ, Moreno V, Xu Q, Konta T, Nakayama K, Furusu A, Sepulveda JC, Kitamura M. Upregulation of cyclooxygenases by retinoic acid in rat mesangial cells.
Pharmacology 79: 57-64 (2006).
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Allegretto EA, McClurg MR, Lazarchik SB, Clemm DL, Kerner SA, Elgort MG, Boehm MF, White SK, Pike JW, Heyman RA. Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism.
J. Biol. Chem. 268: 26625-26633 (1993).
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Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, et al. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Proc. Natl. Acad. Sci. U.S.A. 90: 30-34 (1993).
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Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. Chromosomal localization of the human retinoid X receptors.
Genomics 20: 397-403 (1994).
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Alotaibi H, Yaman E, Salvatore D, Di Dato V, Telkoparan P, Di Lauro R, Tazebay UH. Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription.
Nucleic Acids Res. Jan 31 [Epub ahead of print] (2010).
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Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H. RAR and RXR modulation in cancer and metabolic disease.
Nat. Rev. Drug Discov. 6: 793-810 (2007).
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Altucci L, Rossin A, Hirsch O, Nebbioso A, Vitoux D, Wilhelm E, Guidez F, De Simone M, Schiavone EM, Grimwade D, Zelent A, de The H, Gronemeyer H. Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase a-mediated desubordination of retinoid X receptor.
Cancer Res. 65: 8754-8765 (2005).
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Alvarez R, Checa M, Brun S, Vinas O, Mampel T, Iglesias R, Giralt M, Villarroya F. Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids.
Biochem. J. 345: 91-97 (2000).
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Alvarez R, de Andres J, Yubero P, Vinas O, Mampel T, Iglesias R, Giralt M, Villarroya F. A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene.
J. Biol. Chem. 270: 5666-5673 (1995).
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Alvarez R, Vega MJ, Kammerer S, Rossin A, Germain P, Gronemeyer H, de Lera AR. 9-cis-Retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.
Bioorg. Med. Chem. Lett. 14: 6117-6122 (2004).
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Alvarez S, Alvarez R, Khanwalkar H, Germain P, Lemaire G, Rodriguez-Barrios F, Gronemeyer H, de Lera AR. Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.
Bioorg. Med. Chem. 17: 4345-4359 (2009).
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Alvarez S, Pazos-Randulfe Y, Khanwalkar H, Germain P, Alvarez R, Gronemeyer H, de Lera AR. New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Bioorg. Med. Chem. 16: 9719-9728 (2008).
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Alvaro A, Rosales R, Masana L, Vallve JC. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids.
J. Nutr. Biochem. May 13 [Epub ahead of print] (2009).
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Amantana A, Moulton HM, Cate ML, Reddy MT, Whitehead T, Hassinger JN, Youngblood DS, Iversen PL. Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.
Bioconjug. Chem. 18: 1325-1331 (2007).
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Amengual J, Ribot J, Bonet ML, Palou A. Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice.
Obesity (Silver Spring) 16: 585-591 (2008).
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Anakk S, Kalsotra A, Shen Q, Vu MT, Staudinger JL, Davies PJ, Strobel HW. Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.
FASEB J. 17: 1736-1738 (2003).
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Anand PK, Kaul D. Downregulation of TACO gene transcription restricts mycobacterial entry/survival within human macrophages.
FEMS Microbiol. Lett. 250: 137-144 (2005).
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Anand PK, Kaul D, Sharma M. Synergistic action of vitamin D and retinoic acid restricts invasion of macrophages by pathogenic mycobacteria.
J. Microbiol. Immunol. Infect. 41: 17-25 (2008).
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Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.
J. Biol. Chem. 276: 28857-28865 (2001).
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Anderson SP, Dunn C, Laughter A, Yoon L, Swanson C, Stulnig TM, Steffensen KR, Chandraratna RA, Gustafsson JA, Corton JC. Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor and liver X receptor in mouse liver.
Mol. Pharmacol. 66: 1440-1452 (2004).
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Angelo G, Lamon-Fava S, Sonna LA, Lindauer ML, Wood RJ. Heat shock protein 90beta: a novel mediator of vitamin D action.
Biochem. Biophys. Res. Commun. 367: 578-583 (2008).
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Anthonisen EH, Berven L, Holm S, Nygard M, Nebb HI, Gronning-Wang LM. The nuclear receptor LXR is O-GlcNAc modified in response to glucose.
J. Biol. Chem. Nov 20 [Epub ahead of print] (2009).
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Aoki K, Nakajima M, Hoshi Y, Saso N, Kato S, Sugiyama Y, Sato H. Effect of aminoguanidine on lipopolysaccharide-induced changes in rat liver transporters and transcription factors.
Biol. Pharm. Bull. 31: 412-420 (2008).
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Aoudjit F, Brochu N, Morin N, Poulin G, Stratowa C, Audette M. Heterodimeric retinoic acid receptor-beta and retinoid X receptor-alpha complexes stimulate expression of the intercellular adhesion molecule-1 gene.
Cell Growth Differ. 6: 515-521 (1995).
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Aquino JB, Marmigere F, Lallemend F, Lundgren TK, Villar MJ, Wegner M, Ernfors P. Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.
Gene Expr. Patterns 8: 217-226 (2008).
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Araki H, Tamada Y, Imoto S, Dunmore B, Sanders D, Humphrey S, Nagasaki M, Doi A, Nakanishi Y, Yasuda K, Tomiyasu Y, Tashiro K, Print C, Charnock-Jones DS, Kuhara S, Miyano S. Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells.
Angiogenesis 12: 221-229 (2009).
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Araki O, Ying H, Furuya F, Zhu X, Cheng SY. Thyroid hormone receptor beta mutants: dominant negative regulators of peroxisome proliferator-activated receptor gamma action.
Proc. Natl. Acad. Sci. U.S.A. 102: 16251-16256 (2005).
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Aranda A, Pascual A. Nuclear hormone receptors and gene expression.
Physiol. Rev. 81: 1269-1304 (2001).
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Arrese M, Trauner M, Ananthanarayanan M, Pizarro M, Solis N, Accatino L, Soroka C, Boyer JL, Karpen SJ, Miquel JF, Suchy FJ. Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat.
J. Hepatol. 38: 148-155 (2003).
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Arukwe A, Nordbo B. Hepatic biotransformation responses in Atlantic salmon exposed to retinoic acids and 3,3',4,4'-tetrachlorobiphenyl (PCB congener 77).
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 147: 470-482 (2008).
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Aubry EM, Odermatt A. Retinoic acid reduces glucocorticoid sensitivity in C2C12 myotubes by decreasing 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor activities.
Endocrinology 150: 2700-2708 (2009).
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Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ. CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.
Drug Metab. Dispos. 35: 428-439 (2007).
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Auerbach SS, Stoner MA, Su S, Omiecinski CJ. Retinoid X receptor-dependent transactivation by a naturally occurring structural variant of human CAR (NR1I3).
Mol. Pharmacol. 68: 1239-1253 (2005).
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Azzi A, Gysin R, Kempna P, Munteanu A, Negis Y, Villacorta L, Visarius T, Zingg JM. Vitamin E mediates cell signaling and regulation of gene expression.
Ann. N. Y. Acad. Sci. 1031: 86-95 (2004).
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Azzi A, Gysin R, Kempna P, Munteanu A, Villacorta L, Visarius T, Zingg JM. Regulation of gene expression by alpha-tocopherol.
Biol. Chem. 385: 585-591 (2004).
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Bae Y, Kemper JK, Kemper B. Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
DNA Cell Biol. 23: 81-91 (2004).
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Baes M, Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.
Mol. Cell Biol. 14: 1544-1552 (1994).
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Bai P, Houten SM, Huber A, Schreiber V, Watanabe M, Kiss B, de Murcia G, Auwerx J, Menissier-de Murcia J. PARP-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the RXR/PPARgamma heterodimer.
J. Biol. Chem. 282: 37738-37746 (2007).
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Balasubramanian S, Chandraratna RA, Eckert RL. Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid.
Carcinogenesis 25: 1377-1385 (2004).
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Balasubramaniyan N, Shahid M, Suchy FJ, Ananthanarayanan M. Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development.
Am. J. Physiol. Gastrointest. Liver Physiol. 288: G251-G260 (2005).
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Baldan A, Relat J, Marrero PF, Haro D. Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation.
Nucleic Acids Res. 32: 4742-4749 (2004).
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Barak Y, Sadovsky Y, Shalom-Barak T. PPAR signaling in placental development and function.
PPAR Res. 2008: 142082 (2008).
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Baranowski M. Biological role of liver X receptors.
J. Physiol. Pharmacol. 59 Suppl. 7: 31-55 (2008).
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Barbera MJ, Schluter A, Pedraza N, Iglesias R, Villarroya F, Giralt M. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.
J. Biol. Chem. 276: 1486-1493 (2001).
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Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.
Gastroenterology 124: 1926-1940 (2003).
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Barletta F, Freedman LP, Christakos S. Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex.
Mol. Endocrinol. 16: 301-314 (2002).
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Barra GB, Velasco LF, Pessanha RP, Campos AM, Moura FN, Dias SM, Polikarpov I, Ribeiro RC, Simeoni LA, Neves FA. Molecular mechanism of thyroid hormone action.
Arq. Bras. Endocrinol. Metabol. 48: 25-39 (2004).
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Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, Wotton D. TGIF inhibits retinoid signaling.
Mol. Cell. Biol. 26: 990-1001 (2006).
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Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Mol. Carcinog. 44: 151-161 (2005).
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Bastie JN, Balitrand N, Guidez F, Guillemot I, Larghero J, Calabresse C, Chomienne C, Delva L. 1 alpha,25-Dihydroxyvitamin D3 transrepresses retinoic acid transcriptional activity via vitamin D receptor in myeloid cells.
Mol. Endocrinol. 18: 2685-2699 (2004).
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Bastien J, Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes.
Gene 328: 1-16 (2004).
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Beaudet MJ, Desrochers M, Lachaud AA, Anderson A. The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta, and the liver X receptor.
Biochem. J. 388: 407-418 (2005).
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Beck Y, Delaporte C, Moras D, Richards G, Billas IM. The ligand-binding domains of the three USP/RXR nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila.
Dev. Biol. 330: 1-11 (2009).
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Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. The acute phase response is associated with retinoid X receptor repression in rodent liver.
J. Biol. Chem. 275: 16390-16399 (2000).
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Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.
Biochem. Biophys. Res. Commun. 293: 145-149 (2002).
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Belanger AJ, Luo Z, Vincent KA, Akita GY, Cheng SH, Gregory RJ, Jiang C. Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor.
Biochem. Biophys. Res. Commun. 364: 567-572 (2007).
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Beltowski J. Liver X receptors (LXR) as therapeutic targets in dyslipidemia.
Cardiovasc. Ther. 26: 297-316 (2008).
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Benigni A, Zoja C, Tomasoni S, Campana M, Corna D, Zanchi C, Gagliardini E, Garofano E, Rottoli D, Ito T, Remuzzi G. Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone.
J. Am. Soc. Nephrol. 17: 1624-1632 (2006).
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Bennett DJ, Carswell EL, Cooke AJ, Edwards AS, Nimz O. Design, structure activity relationships and X-ray co-crystallography of non-steroidal LXR agonists.
Curr. Med. Chem. 15: 195-209 (2008).
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Bennett DJ, Cooke AJ, Edwards AS. Non-steroidal LXR agonists; an emerging therapeutic strategy for the treatment of atherosclerosis.
Recent Patents Cardiovasc. Drug Discov. 1: 21-46 (2006).
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Bentinger M, Turunen M, Zhang XX, Wan YJ, Dallner G. Involvement of retinoid X receptor alpha in coenzyme Q metabolism.
J. Mol. Biol. 326: 795-803 (2003).
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Bergasa NV, Mason A, Floreani A, Heathcote J, Swain MG, Jones DE, Lindor KM, Bassendine MF, Worman HJ. Primary biliary cirrhosis: report of a focus study group.
Hepatology 40: 1013-1020 (2004).
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Berger J, Moller DE. The mechanisms of action of PPARs.
Annu. Rev. Med. 53: 409-435 (2002).
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Berger J, Wagner JA. Physiological and therapeutic roles of peroxisome proliferator-activated receptors.
Diabetes Technol. Ther. 4: 163-174 (2002).
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Berghofer-Hochheimer Y, Zurek C, Langer G, Munder T. Expression of the vitamin D and the retinoid X receptors in Saccharomyces cerevisiae: alternative in vivo models for ligand-induced transactivation.
J. Cell. Biochem. 66: 184-196 (1997).
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Berghofer-Hochheimer Y, Zurek C, Wolfl S, Hemmerich P, Munder T. L7 protein is a coregulator of vitamin D receptor-retinoid X receptor-mediated transactivation.
J. Cell. Biochem. 69: 1-12 (1998).
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Berrougui H, Khalil A. Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity.
Rejuvenation Res. 12: 117-126 (2009).
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Bettoun DJ, Burris TP, Houck KA, Buck DW 2nd, Stayrook KR, Khalifa B, Lu J, Chin WW, Nagpal S. Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.
Mol. Endocrinol. 17: 2320-2328 (2003).
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Bhadhprasit W, Sakuma T, Hatakeyama N, Fuwa M, Kitajima K, Nemoto N. Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone.
Drug Metab. Dispos. 35: 1880-1885 (2007).
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Bhat MK, Ashizawa K, Cheng SY. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.
Proc. Natl. Acad. Sci. U.S.A. 91: 7927-7931 (1994).
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Bianchi MG, Gazzola GC, Cagnin S, Kagechika H, Bussolati O. The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.
Biochim. Biophys. Acta 1788: 1861-1868 (2009).
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Bich C, Bovet C, Rochel N, Peluso-Iltis C, Panagiotidis A, Nazabal A, Moras D, Zenobi R. Detection of nucleic acid-nuclear hormone receptor complexes with mass spectrometry.
J. Am. Soc. Mass Spectrom. Dec 28 [Epub ahead of print] (2009).
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Bishop-Bailey D. The platelet as a model system for the acute actions of nuclear receptors.
Steroids Sep 21 [Epub ahead of print] (2009).
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Bissonnette RP, Brunner T, Lazarchik SB, Yoo NJ, Boehm MF, Green DR, Heyman RA. 9-cis Retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of Fas ligand and requires retinoic acid receptor and retinoid X receptor activation.
Mol. Cell. Biol. 15: 5576-5585 (1995).
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Bjorkholm B, Bok CM, Lundin A, Rafter J, Hibberd ML, Pettersson S. Intestinal microbiota regulate xenobiotic metabolism in the liver.
PLoS One 4: e6958 (2009).
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Blomhoff HK. Vitamin A regulates proliferation and apoptosis of human T- and B-cells.
Biochem. Soc. Trans. 32: 982-984 (2004).
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Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM. Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.
Proc. Natl. Acad. Sci. U.S.A. 89: 2321-2325 (1992).
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Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, Evans RM. SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
Genes Dev. 12: 3195-3205 (1998).
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Bock HH, Lammert F. Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense.
Hepatology 35: 232-234 (2002).
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Boehm MF, Zhang L, Badea BA, White SK, Mais DE, Berger E, Suto CM, Goldman ME, Heyman RA. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
J. Med. Chem. 37: 2930-2941 (1994).
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Bogazzi F, Bartalena L, Brogioni S, Burelli A, Grasso L, Dell'Unto E, Manetti L, Martino E. L-Thyroxine directly affects expression of thyroid hormone-sensitive genes: regulatory effect of RXRbeta.
Mol. Cell. Endocrinol. 134: 23-31 (1997).
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Bogos K, Renyi-Vamos F, Kovacs G, Tovari J, Dome B. Role of retinoic receptors in lung carcinogenesis.
J. Exp. Clin. Cancer Res. 27: 18 (2008).
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Bohme M, Nitz I, Doring F, Klapper M. Analysis of the transcriptional regulation of the FABP2 promoter haplotypes by PPARgamma/RXRalpha and Oct-1.
Biochim. Biophys. Acta 1779: 616-621 (2008).
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Bondioni S, Angioni AR, Corbetta S, Locatelli M, Ferrero S, Ferrante E, Mantovani G, Olgiati L, Beck-Peccoz P, Spada A, Lania AG. Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells.
Exp. Biol. Med. (Maywood) 233: 439-446 (2008).
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Bonet ML, Puigserver P, Serra F, Ribot J, Vazquez F, Pico C, Palou A. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes.
FEBS Lett. 406: 196-200 (1997).
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Bonilla S, Redonnet A, Noel-Suberville C, Groubet R, Pallet V, Higueret P. Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver.
J. Physiol. Biochem. 57: 1-8 (2001).
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Bonilla S, Redonnet A, Noel-Suberville C, Pallet V, Garcin H, Higueret P. High-fat diets affect the expression of nuclear retinoic acid receptor in rat liver.
Br. J. Nutr. 83: 665-671 (2000).
*
-
Bonofiglio D, Cione E, Qi H, Pingitore A, Perri M, Catalano S, Vizza D, Panno ML, Genchi G, Fuqua SA, Ando S. Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.
Am. J. Pathol. 175: 1270-1280 (2009).
*
-
Bordoni A, Di Nunzio M, Danesi F, Biagi PL. Polyunsaturated fatty acids: from diet to binding to PPARs and other nuclear receptors.
Genes Nutr. 1: 95-106 (2006).
*
-
Borel V, Marceau G, Gallot D, Blanchon L, Sapin V. Retinoids regulate human amniotic tissue-type plasminogen activator gene by a two-step mechanism.
J. Cell. Mol. Med. Jun 16 [Epub ahead of print] (2009).
*
-
Borland MG, Foreman JE, Girroir EE, Zolfaghari R, Sharma AK, Amin SM, Gonzalez FJ, Ross AC, Peters JM. Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell proliferation in human HaCaT keratinocytes.
Mol. Pharmacol. 74: 1429-1442 (2008).
*
-
Borutinskaite VV, Navakauskiene R, Magnusson KE. Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells.
Ann. N. Y. Acad. Sci. 1091: 346-355 (2006).
*
-
Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T. Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation.
J. Biol. Chem. 272: 9443-9449 (1997).
*
-
Boudjelal M, Voorhees JJ, Fisher GJ. Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells.
Exp. Cell Res. 274: 130-137 (2002).
*
-
Boudjelal M, Wang Z, Voorhees JJ, Fisher GJ. Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes.
Cancer Res. 60: 2247-2252 (2000).
*
-
Boulanger A, McLemore P, Copeland NG, Gilbert DJ, Jenkins NA, Yu SS, Gentleman S, Redmond TM. Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene.
FASEB J. 17: 1304-1306 (2003).
*
-
Bour G, Gaillard E, Bruck N, Lalevee S, Plassat JL, Busso D, Samama JP, Rochette-Egly C. Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7.
Proc. Natl. Acad. Sci. U.S.A. 102: 16608-16613 (2005).
*
-
Bourhis E, Maheux J, Paquet B, Kagechika H, Shudo K, Rompre PP, Rouillard C, Levesque D. The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.
Psychopharmacology (Berl.) 202: 635-648 (2009).
-
Bouton D, Escriva H, de Mendonca RL, Glineur C, Bertin B, Noel C, Robinson-Rechavi M, de Groot A, Cornette J, Laudet V, Pierce RJ. A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabrata transactivates transcription in the presence of retinoids.
J. Mol. Endocrinol. 34: 567-582 (2005).
*
-
Boyer JL, Denk G, Bohan A, Chen WS, Soroka C, Denson L. Adaptive regulation of bile salt transporters in cholestasis.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 46-47. June 18-19 (2004). *
-
Boylan JF, Lufkin T, Achkar CC, Taneja R, Chambon P, Gudas LJ. Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.
Mol. Cell. Biol. 15: 843-851 (1995).
*
-
Boyle LH, Gillingham AK, Munro S, Trowsdale J. Selective export of HLA-F by its cytoplasmic tail.
J. Immunol. 176: 6464-6472 (2006).
*
-
Brabender J, Metzger R, Salonga D, Danenberg KD, Danenberg PV, Holscher AH, Schneider PM. Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis.
Carcinogenesis 26: 525-530 (2005).
*
-
Braun S, Azoitei A, Spindler-Barth M. DNA-binding properties of Drosophila ecdysone receptor isoforms and their modification by the heterodimerization partner ultraspiracle.
Arch. Insect. Biochem. Physiol. 72: 172-191 (2009).
-
Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, Pascussi JM. Hepatic expression of thyroid hormone-responsive Spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
Endocrinology Feb 25 [Epub ahead of print] (2010).
-
Brewer M, Kirkpatrick ND, Wharton JT, Wang J, Hatch K, Auersperg N, Utzinger U, Gershenson D, Bast R, Zou C. 4-HPR modulates gene expression in ovarian cells.
Int. J. Cancer 119: 1005-1013 (2006).
*
-
Brinckerhoff CE, Sporn MB. Retinoids and rexinoids for the 21st century: a brave new world for arthritis.
J. Rheumatol. 30: 211-213 (2003).
-
Brown TR, Stonehouse TJ, Branch JS, Brickell PM, Katz DR. Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D.
Exp. Cell Res. 236: 94-102 (1997).
*
-
Brtko J. Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention.
Cent. Eur. J. Public Health 15: 3-6 (2007).
-
Brtko J. Retinoids, rexinoids and their cognate nuclear receptors: character and their role in chemoprevention of selected malignant diseases.
Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 151: 187-194 (2007).
*
-
Brtko J, Rock E, Nezbedova P, Krizanova O, Dvorcakova M, Minet-Quinard R, Farges MC, Ribalta J, Winklhofer-Roob BM, Vasson MP, Macejova D. Age-related change in the retinoid X receptor beta gene expression in peripheral blood mononuclear cells of healthy volunteers: effect of 13-cis retinoic acid supplementation.
Mech. Ageing Dev. 128: 594-600 (2007).
-
Brtko J, Thalhamer J. Renaissance of the biologically active vitamin A derivatives: established and novel directed therapies for cancer and chemoprevention.
Curr. Pharm. Des. 9: 2067-2077 (2003).
-
Bruck N, Bastien J, Bour G, Tarrade A, Plassat JL, Bauer A, Adam-Stitah S, Rochette-Egly C. Phosphorylation of the retinoid X receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.
Cell. Signal. 17: 1229-1239 (2005).
*
-
Bruck R, Weiss S, Aeed H, Pines M, Halpern Z, Zvibel I. Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.
Dig. Dis. Sci. 54: 292-299 (2009).
*
-
Bu P, Wan YJ. Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent.
BMC Cancer 7: 236 (2007).
*
-
Buaud B, Esterle L, Vaysse C, Alfos S, Combe N, Higueret P, Pallet V. A high-fat diet induces lower expression of retinoid receptors and their target genes GAP-43/neuromodulin and RC3/neurogranin in the rat brain.
Br. J. Nutr. Jan 27 [Epub ahead of print] (2010).
*
-
Buck J, Myc A, Garbe A, Cathomas G. Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes.
J. Cell Biol. 115: 851-859 (1991).
*
-
Budhu AS, Noy N. On the role of the carboxyl-terminal helix of RXR in the interactions of the receptor with ligand.
Biochemistry 39: 4090-4095 (2000).
*
-
Bungard CI, McGivan JD. Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers.
Arch. Biochem. Biophys. 443: 53-59 (2005).
*
-
Burk O, Arnold KA, Geick A, Tegude H, Eichelbaum M. A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.
Biol. Chem. 386: 503-513 (2005).
-
Buroker NE, Barboza J, Huang JY. The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene.
FEBS J. 276: 3247-3255 (2009).
*
-
Buroker NE, Young ME, Wei C, Serikawa K, Ge M, Ning XH, Portman MA. The dominant negative thyroid hormone receptor beta mutant Delta337T alters peroxisome proliferator-activated receptor alpha signaling in heart.
Am. J. Physiol. Endocrinol. Metab. 292: E453-E460 (2007).
*
-
Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE. Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand.
Arthritis Rheum. 56: 892-904 (2007).
*
-
Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE. Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.
Arthritis Res. Ther. 10: R139 (2008).
*
-
Cabrero A, Laguna JC, Vazquez M. Peroxisome proliferator-activated receptors and the control of inflammation.
Curr. Drug Targets Inflamm. Allergy 1: 243-248 (2002).
-
Cadoudal T, Glorian M, Massias A, Fouque F, Forest C, Benelli C. Retinoids upregulate phosphoenolpyruvate carboxykinase and glyceroneogenesis in human and rodent adipocytes.
J. Nutr. 138: 1004-1009 (2008).
*
-
Cai Y, Dai T, Ao Y, Konishi T, Chuang KH, Lue Y, Chang C, Wan YJ. Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice.
Endocrinology 144: 2311-2318 (2003).
*
-
Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ. The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
Eur. J. Pharm. Sci. 15: 89-96 (2002).
*
-
Calderon F, Kim HY. Role of RXR in neurite outgrowth induced by docosahexaenoic acid.
Prostaglandins Leukot. Essent. Fatty Acids 77: 227-232 (2007).
*
-
Calgaro MR, Neto MD, Figueira AC, Santos MA, Portugal RV, Guzzi CA, Saidemberg DM, Bleicher L, Vernal J, Fernandez P, Terenzi H, Palma MS, Polikarpov I. Orphan nuclear receptor NGFI-B forms dimers with nonclassical interface.
Protein Sci. 16: 1762-1772 (2007).
*
-
Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P. Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Genes Dev. 20: 1525-1538 (2006).
*
-
Camacho M, Rodriguez C, Salazar J, Martinez-Gonzalez J, Ribalta J, Escudero JR, Masana L, Vila L. Retinoic acid induces PGI-synthase expression in human endothelial cells.
J. Lipid Res. 49: 1707-1714 (2008).
*
-
Cao G, Beyer TP, Yang XP, Schmidt RJ, Zhang Y, Bensch WR, Kauffman RF, Gao H, Ryan TP, Liang Y, Eacho PI, Jiang XC. Phospholipid transfer protein is regulated by liver X receptors in vivo.
J. Biol. Chem. 277: 39561-39565 (2002).
*
-
Cao X, Liu W, Lin F, Li H, Kolluri SK, Lin B, Han YH, Dawson MI, Zhang XK. Retinoid X receptor regulates Nur77/TR3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting.
Mol. Cell. Biol. 24: 9705-9725 (2004).
*
-
Carfi' M, Croera C, Ferrario D, Campi V, Bowe G, Pieters R, Gribaldo L. TBTC induces adipocyte differentiation in human bone marrow long term culture.
Toxicology 249: 11-18 (2008).
*
-
Carlberg C. Lipid soluble vitamins in gene regulation.
Biofactors 10: 91-97 (1999).
-
Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker W. Two nuclear signalling pathways for vitamin D.
Nature 361: 657-660 (1993).
*
-
Carlberg C, Dunlop TW. The impact of chromatin organization of vitamin D target genes.
Anticancer Res. 26: 2637-2645 (2006).
-
Carlberg C, Mathiasen IS, Saurat JH, Binderup L. The 1,25-dihydroxyvitamin D3 (VD) analogues MC903, EB1089 and KH1060 activate the VD receptor: homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors.
J. Steroid Biochem. Mol. Biol. 51: 137-142 (1994).
-
Carlberg C, Saurat JH, Siegenthaler G. 9-cis-Retinoic acid is a natural antagonist for the retinoic acid receptor response pathway.
Biochem. J. 295: 343-346 (1993).
*
-
Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR.
Curr. Drug Metab. 6: 357-367 (2005).
-
Carta M, Stancampiano R, Tronci E, Collu M, Usiello A, Morelli M, Fadda F. Vitamin A deficiency induces motor impairments and striatal cholinergic dysfunction in rats.
Neuroscience 139: 1163-1172 (2006).
*
-
Castelein H, Declercq PE, Baes M. DNA binding preferences of PPAR alpha/RXR alpha heterodimers.
Biochem. Biophys. Res. Commun. 233: 91-95 (1997).
*
-
Castillo AI, Sanchez-Martinez R, Moreno JL, Martinez-Iglesias OA, Palacios D, Aranda A. A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.
Mol. Cell. Biol. 24: 502-513 (2004).
*
-
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
J. Biol. Chem. 278: 10443-10449 (2003).
*
-
Cavasotto CN, Liu G, James SY, Hobbs PD, Peterson VJ, Bhattacharya AA, Kolluri SK, Zhang XK, Leid M, Abagyan R, Liddington RC, Dawson MI. Determinants of retinoid X receptor transcriptional antagonism.
J. Med. Chem. 47: 4360-4372 (2004).
*
-
Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P. Valproic acid induces CYP3A4 and MDR1 genes expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Drug Metab. Dispos. 35: 1032-1041 (2007).
*
-
Cesario RM, Stone J, Yen WC, Bissonnette RP, Lamph WW. Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer.
Cancer Lett. 240: 225-233 (2006).
*
-
Chai D, Wang B, Shen L, Pu J, Zhang XK, He B. RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells.
Free Radic. Biol. Med. 44: 1334-1347 (2008).
-
Chakravarti N, El-Naggar AK, Lotan R, Anderson J, Diwan AH, Saadati HG, Diba R, Prieto VG, Esmaeli B. Expression of retinoid receptors in sebaceous cell carcinoma.
J. Cutan. Pathol. 33: 10-17 (2006).
*
-
Chakravarti N, Lotan R, Diwan AH, Warneke CL, Johnson MM, Prieto VG. Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosis.
Clin. Cancer Res. 13: 4817-4824 (2007).
*
-
Chambon P. A decade of molecular biology of retinoic acid receptors.
FASEB J. 10: 940-954 (1996).
*
-
Chambon P. The retinoid signaling pathway: molecular and genetic analyses.
Semin. Cell Biol. 5: 115-125 (1994).
-
Chan LS, Wells RA. Manipulation of reciprocal salt bridges at the heterodimerization interface alters the dimerization properties of mouse RXRalpha and PPARgamma1.
Biochem. Biophys. Res. Commun. 358: 1080-1085 (2007).
*
-
Chan LS, Wells RA. Cross-talk between PPARs and the partners of RXR: a molecular perspective.
PPAR Res. 2009: 925309 (2009).
*
-
Chan SS, Schedlich LJ, Twigg SM, Baxter RC. Inhibition of adipocyte differentiation by insulin-like growth factor binding protein-3.
Am. J. Physiol. Endocrinol. Metab. 296: E654-E663 (2009).
*
-
Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA.
Nature 456: 350-356 (2008).
*
-
Chang BE, Blader P, Fischer N, Ingham PW, Strahle U. Axial (HNF3beta) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter.
EMBO J. 16: 3955-3964 (1997).
*
-
Chang SC, Rashid A, Gao YT, Andreotti G, Shen MC, Wang BS, Han TQ, Zhang BH, Sakoda LC, Leitzmann MF, Chen BE, Rosenberg P, Chen J, Chanock S, Hsing AW. Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.
Carcinogenesis 29: 944-948 (2008).
*
-
Chao C, Youssef J, Rezaiekhaleigh M, Birnbaum LS, Badr M. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha.
Mech. Ageing Dev. 123: 1469-1476 (2002).
-
Chapellier B, Mark M, Messaddeq N, Calleja C, Warot X, Brocard J, Gerard C, Li M, Metzger D, Ghyselinck NB, Chambon P. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.
EMBO J. 21: 3402-3413 (2002).
*
-
Chavoshi TM, Moussian B, Uv A. Tissue-autonomous EcR functions are required for concurrent organ morphogenesis in the Drosophila embryo.
Mech. Dev. Jan 18 [Epub ahead of print] (2010).
-
Chen BC, Kuo KK, Chen YH, Liu CH, Tsai LY, Hsu HK, Hsu C. Retinoid X receptor alpha participation in dexamethasone induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
Shock 32: 164-171 (2009).
-
Chen C, Zhang J, Li J, Huang J, Yang C, Huang G, Shi J. Hydrodynamic-based in vivo transfection of retinoic X receptor-alpha gene can enhance vitamin A-induced attenuation of liver fibrosis in mice.
Liver Int. 24: 679-686 (2004).
*
-
Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Proc. Natl. Acad. Sci. U.S.A. 101: 11245-11250 (2004).
*
-
Chen G, Zhang Y, Lu D, Li NQ, Ross AC. Retinoids synergize with insulin to induce hepatic Gck Expression.
Biochem. J. 419: 645-653 (2009).
*
-
Chen GQ, Lin B, Dawson MI, Zhang XK. Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.
Int. J. Cancer 99: 171-178 (2002).
*
-
Chen H, Hewison M, Adams JS. Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element binding protein.
J. Biol. Chem. 281: 39114-39120 (2006).
*
-
Chen J, Raymond K. Treatment effect of rifampicin on cholestasis.
The Internet Journal of Pharmacology Vol. 4 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol4n2/colestasis.xml) (2006). *
-
Chen M, Beaven SW, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
J. Lipid Res. 46: 2570-2579 (2005).
*
-
Chen S, Wang K, Wan YJ. Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.
Biochem. Pharmacol. 79: 270-276 (2010).
*
-
Chen W, Cai SY, Xu S, Denson L, Soroka C, Boyer JL. Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.
Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1221-G1227 (2007).
*
-
Chen X, Chen F, Liu S, Glaeser H, Dawson PA, Hofmann AF, Kim RB, Shneider BL, Pang KS. Transactivation of rat ASBT and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor (VDR).
Mol. Pharmacol. 69: 1913-1923 (2006).
*
-
Chen X, Esplin BL, Garrett KP, Welner RS, Webb CF, Kincade PW. Retinoids accelerate B lineage lymphoid differentiation.
J. Immunol. 180: 138-145 (2008).
*
-
Chen X, Zhang J, Baker SM, Chen G. Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).
Toxicology 231: 224-233 (2007).
*
-
Chen Y, Hu X, Wei LN. Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140.
Mol. Cell. Endocrinol. 226: 43-50 (2004).
-
Chen YH, Hong IC, Kuo KK, Hsu HK, Hsu C. Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyl transferase in liver during sepsis.
Shock 28: 65-70 (2007).
*
-
Chen ZP, Shemshedini L, Durand B, Noy N, Chambon P, Gronemeyer H. Pure and functionally homogeneous recombinant retinoid X receptor.
J. Biol. Chem. 269: 25770-25776 (1994).
*
-
Cheng C, Michaels J, Scheinfeld N. Alitretinoin: a comprehensive review.
Expert Opin. Investig. Drugs 17: 437-443 (2008).
-
Cheng YH, Yin P, Xue Q, Yilmaz B, Dawson MI, Bulun SE. Retinoic acid regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of retinoic acid receptors with SP1/SP3 for estradiol metabolism.
J. Clin. Endocrinol. Metab. 93: 1915-1923 (2008).
*
-
Cheroki C, Krepischi-Santos AC, Rosenberg C, Jehee FS, Mingroni-Netto RC, Filho IP, Filho SZ, Kim CA, Bagnoli VR, Mendonca BB, Szuhai K, Otto PA. Report of a del22q11 in a patient with Mayer-Rokitansky-Kuster-Hauser (MRKH) anomaly and exclusion of WNT-4, RAR-gamma, and RXR-alpha as major genes determining MRKH anomaly in a study of 25 affected women.
Am. J. Med. Genet. A. 140: 1339-1342 (2006).
-
Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
Drug Metab. Dispos. 31: 1315-1319 (2003).
*
-
Cheskis B, Freedman LP. Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.
Mol. Cell. Biol. 14: 3329-3338 (1994).
*
-
Cheung B, Yan J, Smith SA, Nguyen T, Lee M, Kavallaris M, Norris MD, Haber M, Marshall GM. Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter.
Int. J. Cancer 105: 856-867 (2003).
*
-
Chiang JY, Kimmel R, Stroup D. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Gene 262: 257-265 (2001).
*
-
Chiang JY, Kimmel R, Weinberger C, Stroup D. Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
J. Biol. Chem. 275: 10918-10924 (2000).
*
-
Chiaw PK, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE. Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs.
Chem. Biol. 16: 520-530 (2009).
-
Chiba H, Clifford J, Metzger D, Chambon P. Specific and redundant functions of retinoid X receptor/retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.
J. Cell Biol. 139: 735-747 (1997).
*
-
Chignard N, Mergey M, Barbu V, Finzi L, Tiret E, Paul A, Housset C. VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.
Hepatology 42: 549-557 (2005).
*
-
Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, Kato Y, Makishima M. The basic helix-loop-helix proteins DEC1 and DEC2 function as corepressors of retinoid X receptors.
Mol. Pharmacol. 76: 1360-1369 (2009).
-
Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
J. Biol. Chem. 281: 30669-30677 (2006).
*
-
Chopra B, Hinley J, Oleksiewicz MB, Southgate J. Trans-species comparison of PPAR and RXR expression by rat and human urothelial tissues.
Toxicol. Pathol. 36: 485-495 (2008).
*
-
Choudhary R, Baker KM, Pan J. All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis.
J. Cell. Physiol. 215: 172-181 (2008).
*
-
Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.
J. Exp. Med. 203: 2589-2602 (2006).
*
-
Christakos S, Dhawan P, Liu Y, Peng X, Porta A. New insights into the mechanisms of vitamin D action.
J. Cell. Biochem. 88: 695-705 (2003).
*
-
Christakos S, Raval-Pandya M, Wernyj RP, Yang W. Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3.
Biochem. J. 316: 361-371 (1996).
*
-
Christoffolete M, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco A, Gereben B. Regulation of thyroid hormone activation via the LXR/RXR pathway.
J. Endocrinol. Feb 22 [Epub ahead of print] (2010).
*
-
Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YJ, Chang C. 9-Cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor.
Mol. Endocrinol. 19: 1200-1212 (2005).
*
-
Chung C, Doll JA, Stellmach VM, Gonzales J, Surapureddi S, Cornwell M, Reddy JK, Crawford SE. Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Adv. Exp. Med. Biol. 617: 591-597 (2008).
-
Cignarella A, Engel T, Eckardstein A, Kratz M, Lorkowski S, Lueken A, Assmann G, Cullen P. Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors.
Atherosclerosis 179: 229-236 (2005).
-
Cimini A, Ceru MP. Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation.
Stem Cell Rev. 4: 293-303 (2008).
-
Cimini A, Cristiano L, Benedetti E, D'Angelo B, Ceru MP. PPARs expression in adult mouse neural stem cells: modulation of PPARs during astroglial differentiaton of NSC.
PPAR Res. 2007: 48242 (2007).
*
-
Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2.
J. Biol. Chem. 278: 5760-5767 (2003).
*
-
Clarke N, Germain P, Altucci L, Gronemeyer H. Retinoids: potential in cancer prevention and therapy.
Expert Rev. Mol. Med. 6: 1-23 (2004).
-
Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, Fruchart J, Fruchart JC, Gonzalez FJ, Staels B. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Gastroenterology 125: 544-555 (2003).
*
-
Claudel T, Leibowitz MD, Fievet C, Tailleux A, Wagner B, Repa JJ, Torpier G, Lobaccaro JM, Paterniti JR, Mangelsdorf DJ, Heyman RA, Auwerx J. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.
Proc. Natl. Acad. Sci. U.S.A. 98: 2610-2615 (2001).
*
-
Claudel T, Sturm E, Duez H, Torra IP, Sirvent A, Kosykh V, Fruchart JC, Dallongeville J, Hum DW, Kuipers F, Staels B. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
J. Clin. Invest. 109: 961-971 (2002).
*
-
Clerici C, Castellani D, Russo G, Fiorucci S, Sabatino G, Giuliano V, Gentili G, Morelli O, Raffo P, Baldoni M, Morelli A, Toma S. Treatment with all-trans retinoic acid plus tamoxifen and vitamin E in advanced hepatocellular carcinoma.
Anticancer Res. 24: 1255-1260 (2004).
-
Cobb LJ, Liu B, Lee KW, Cohen P. Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
Cancer Res. 66: 10878-10884 (2006).
*
-
Cobb LJ, Mehta H, Cohen P. Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation.
Mol. Endocrinol. 23: 1624-1633 (2009).
*
-
Coelho SM, Vaisman M, Carvalho DP. Tumour re-differentiation effect of retinoic acid: a novel therapeutic approach for advanced thyroid cancer.
Curr. Pharm. Des. 11: 2525-2531 (2005).
-
Collino M, Patel NS, Thiemermann C. PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury.
Ther. Adv. Cardiovasc. Dis. 2: 179-197 (2008).
-
Collins-Racie LA, Yang Z, Arai M, Li N, Majumdar MK, Nagpal S, Mounts WM, Dorner AJ, Morris E, Lavallie ER. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage. Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis.
Osteoarthritis Cartilage 17: 939-949 (2009).
-
Colnot S, Lambert M, Blin C, Thomasset M, Perret C. Identification of DNA sequences that bind retinoid X receptor-1,25(OH)2D3-receptor heterodimers with high affinity.
Mol. Cell. Endocrinol. 113: 89-98 (1995).
-
Conde I, Lobo MV, Zamora J, Perez J, Gonzalez FJ, Alba E, Fraile B, Paniagua R, Arenas MI. Human pregnane X receptor is expressed in human breast carcinomas, potential heterodimer formation between hPXR and RXR-alpha.
BMC Cancer 8: 174 (2008).
*
-
Conde I, Paniagua R, Fraile B, Ruiz A, Arenas MI. Expression of vitamin D3 receptor and retinoid receptors in human breast cancer: identification of potential heterodimeric receptors.
Int. J. Oncol. 25: 1183-1191 (2004).
-
Congiu M, Mashford ML, Slavin JL, Desmond PV. Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease.
J. Gastroenterol. Hepatol. 24: 1038-1044 (2009).
*
-
Cornwell PD, De Souza AT, Ulrich RG. Profiling of hepatic gene expression in rats treated with fibric acid analogs.
Mutat. Res. 549: 131-145 (2004).
-
Costet P, Lalanne F, Gerbod-Giannone MC, Molina JR, Fu X, Lund EG, Gudas LJ, Tall AR. Retinoic acid receptor-mediated induction of ABCA1 in macrophages.
Mol. Cell. Biol. 23: 7756-7766 (2003).
*
-
Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
J. Biol. Chem. 275: 28240-28245 (2000).
*
-
Coyle AT, O'keeffe MB, Kinsella BT. 15-Deoxy delta-prostaglandin J suppresses transcription by promoter 3 of the human thromboxane A receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells.
FEBS J. 272: 4754-4773 (2005).
*
-
Crabb DW, Galli A, Fischer M, You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.
Alcohol 34: 35-38 (2004).
*
-
Craig TA, Benson LM, Naylor S, Kumar R. Modulation effects of zinc on the formation of vitamin D receptor and retinoid X receptor alpha-DNA transcription complexes: analysis by microelectrospray mass spectrometry.
Rapid Commun. Mass Spectrom. 15: 1011-1016 (2001).
-
Crawford MA, Golfetto I, Ghebremeskel K, Min Y, Moodley T, Poston L, Phylactos A, Cunnane S, Schmidt W. The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants.
Lipids 38: 303-315 (2003).
-
Crestani M, Sadeghpour A, Stroup D, Galli G, Chiang JY. Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
J. Lipid Res. 39: 2192-2200 (1998).
*
-
Crisafulli C, Di Paola R, Mazzon E, Paterniti I, Galuppo M, Genovese T, Bramanti P, Cappellani Ddagger A, Cuzzocrea S. Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.
J. Leukoc. Biol. Dec 22 [Epub ahead of print] (2009).
*
-
Cristiano L, Cimini A, Moreno S, Ragnelli AM, Paola Ceru M. Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures.
Neuroscience 131: 577-587 (2005).
*
-
Crowe DL, Chandraratna RA. A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands.
Breast Cancer Res. 6: R546-R555 (2004).
*
-
Cullingford TE, Bhakoo K, Peuchen S, Dolphin CT, Patel R, Clark JB. Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system.
J. Neurochem. 70: 1366-1375 (1998).
-
Cvekl A, Wang WL. Retinoic acid signaling in mammalian eye development.
Exp. Eye Res. 89: 280-291 (2009).
*
-
Czekaj P. Phenobarbital-induced expression of cytochrome P450 genes.
Acta Biochim. Pol. 47: 1093-1105 (2000).
*
-
D'Acunto C, Gurioli C, Neri I. Plaque stage mycosis fungoides treated with bexarotene at low dosage and UVB-NB.
J. Dermatolog. Treat. Jan 1 [Epub ahead of print] (2009).
-
D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
J. Clin. Invest. 101: 252-262 (1998).
*
-
Dahlman-Wright K, Zhao C. LXR in cholesterol metabolism.
J. Endocrinol. Oct 16 [Epub ahead of print] (2009).
*
-
Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ. RXRalpha regulates the expression of glutathione S-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver.
Mol. Pharmacol. 68: 1590-1596 (2005).
*
-
Dai G, Wan YJ. Animal models of xenobiotic receptors.
Curr. Drug Metab. 6: 341-355 (2005).
-
Dai T, Wu Y, Leng AS, Ao Y, Robel RC, Lu SC, French SW, Wan YJ. RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity.
Exp. Mol. Pathol. 75: 194-200 (2003).
*
-
Darwiche N, Celli G, Tennenbaum T, Glick AB, Yuspa SH, De Luca LM. Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors.
Cancer Res. 55: 2774-2782 (1995).
*
-
Darwish HM, DeLuca HF. Recent advances in the molecular biology of vitamin D action.
Prog. Nucleic Acid Res. Mol. Biol. 53: 321-344 (1996).
-
Davis PA, Jenab M, Vanden Heuvel JP, Furlong T, Taylor S. Tree nut and peanut consumption in relation to chronic and metabolic diseases including allergy.
J. Nutr. 138: 1757S-1762S (2008).
*
-
Davis RA, Attie AD. Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool.
Proc. Natl. Acad. Sci. U.S.A. 105: 4965-4966 (2008).
*
-
Dawson MI. Synthetic retinoids and their nuclear receptors.
Curr. Med. Chem. Anticancer Agents 4: 199-230 (2004).
-
Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
ChemMedChem. 4: 1106-1119 (2009).
*
-
Dawson MI, Zhang XK. Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid.
Curr. Med. Chem. 9: 623-637 (2002).
-
de Groot A, de Rosny E, Juillan-Binard C, Ferrer JL, Laudet V, Pierce RJ, Pebay-Peyroula E, Fontecilla-Camps JC, Borel F. Crystal structure of a novel tetrameric complex of agonist-bound ligand-binding domain of Biomphalaria glabrata retinoid X receptor.
J. Mol. Biol. 354: 841-853 (2005).
*
-
de Lera AR, Bourguet W, Altucci L, Gronemeyer H. Design of selective nuclear receptor modulators: RAR and RXR as a case study.
Nat. Rev. Drug Discov. 6: 811-820 (2007).
*
-
de Urquiza AM, Liu S, Sjoberg M, Zetterstrom RH, Griffiths W, Sjovall J, Perlmann T. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.
Science 290: 2140-2144 (2000).
*
-
de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC. Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.
Endocrinology 150: 2368-2375 (2009).
*
-
Debril MB, Renaud JP, Fajas L, Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor gamma.
J. Mol. Med. 79: 30-47 (2001).
*
-
Degenhardt T, Matilainen M, Herzig KH, Dunlop TW, Carlberg C. The insulin-like growth factor binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors.
J. Biol. Chem. 281: 39607-39619 (2006).
*
-
Degenhardt T, Vaisanen S, Rakhshandehroo M, Kersten S, Carlberg C. Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.
J. Mol. Biol. 388: 225-238 (2009).
*
-
Delage B, Rullier A, Capdepont M, Rullier E, Cassand P. The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers.
Nutr. J. 6: 20 (2007).
*
-
Delmotte MH, Tahayato A, Formstecher P, Lefebvre P. Serine 157, a retinoic acid receptor alpha residue phosphorylated by protein kinase C in vitro, is involved in RXR.RARalpha heterodimerization and transcriptional activity.
J. Biol. Chem. 274: 38225-38231 (1999).
*
-
DeLuca HF, Zierold C. Mechanisms and functions of vitamin D.
Nutr. Rev. 56: S4-S10 (1998).
-
Deng T, Shan S, Li ZB, Wu ZW, Liao CZ, Ko B, Lu XP, Cheng J, Ning ZQ. A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice.
Biol. Pharm. Bull. 28: 1192-1196 (2005).
*
-
Denson LA, Auld KL, Schiek DS, McClure MH, Mangelsdorf DJ, Karpen SJ. Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.
J. Biol. Chem. 275: 8835-8843 (2000).
*
-
Denson LA, Bohan A, Held MA, Boyer JL. Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis.
Gastroenterology 123: 599-607 (2002).
*
-
Denson LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, Karpen SJ. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.
Gastroenterology 121: 140-147 (2001).
*
-
Depoix C, Delmotte MH, Formstecher P, Lefebvre P. Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. A novel mechanism of action for retinoid antagonists.
J. Biol. Chem. 276: 9452-9459 (2001).
*
-
Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.
J. Exp. Med. 193: 827-838 (2001).
*
-
Desvergne B. RXR: from partnership to leadership in metabolic regulations.
Vitam. Horm. 75: 1-32 (2007).
-
Desvergne B, IJpenberg A, Devchand PR, Wahli W. The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling.
J. Steroid Biochem. Mol. Biol. 65: 65-74 (1998).
-
Diab A, Hussain RZ, Lovett-Racke AE, Chavis JA, Drew PD, Racke MK. Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.
J. Neuroimmunol. 148: 116-126 (2004).
-
Diallo EM, Wilhelm KG Jr, Thompson DL, Koenig RJ. Variable RXR requirements for thyroid hormone responsiveness of endogenous genes.
Mol. Cell. Endocrinol. 264: 149-156 (2007).
-
Didierjean L, Sass JO, Carraux P, Grand D, Sorg O, Plum C, Nau H, Saurat JH. Topical 9-cis-retinaldehyde for delivery of 9-cis-retinoic acid in mouse skin.
Exp. Dermatol. 8: 199-203 (1999).
-
Dietrich CG, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink RP, Matern S, Gartung C. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2.
Gastroenterology 126: 1044-1053 (2004).
*
-
Dillard AC, Lane MA. Retinol increases beta-catenin-RXRalpha binding leading to the increased proteasomal degradation of beta-catenin and RXRalpha.
Nutr. Cancer 60: 97-108 (2008).
-
Dillard AC, Lane MA. Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
Mol. Carcinog. 46: 315-329 (2007).
*
-
Dilworth FJ, Fromental-Ramain C, Remboutsika E, Benecke A, Chambon P. Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo.
Proc. Natl. Acad. Sci. U.S.A. 96: 1995-2000 (1999).
*
-
Dinakarpandian D, Raheja V, Mehta S, Schuetz EG, Rogan PK. Tandem machine learning for the identification of genes regulated by transcription factors.
BMC Bioinformatics 6: 204 (2005).
*
-
Dinardo CD, Ky B, Vogl DT, Forfia P, Loren A, Luger S, Mato A, Tsai DE. Differentiation syndrome in non-M3 acute myeloid leukemia treated with the retinoid X receptor agonist bexarotene.
Med. Oncol. 25: 299-302 (2008).
*
-
DiRenzo J, Soderstrom M, Kurokawa R, Ogliastro MH, Ricote M, Ingrey S, Horlein A, Rosenfeld MG, Glass CK. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.
Mol. Cell. Biol. 17: 2166-2176 (1997).
*
-
Dolle P. Developmental expression of retinoic acid receptors (RARs).
Nucl. Recept. Signal. 7: e006 (2009).
*
-
Donato LJ, Suh JH, Noy N. Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling.
Cancer Res. 67: 609-615 (2007).
*
-
Dong A, Huo J, Zhao K, Gao Q, Wei J. 3D-pharmacophore model for RXRgamma receptor agonists.
Neurochem. Int. 54: 286-291 (2009).
-
Dong D, Noy N. Heterodimer formation by retinoid X receptor: regulation by ligands and by the receptor's self-association properties.
Biochemistry 37: 10691-10700 (1998).
*
-
Dong P, Tao Y, Yang Y, Wang W. Expression of retinoic acid receptors in intestinal mucosa and the effect of vitamin A on mucosal immunity.
Nutrition Nov 19 [Epub ahead of print] (2009).
-
Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
Blood 99: 2637-2646 (2002).
*
-
Dong YW, Wang XP, Wu K. Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition.
World J. Gastroenterol. 15: 441-448 (2009).
*
-
Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
J. Lipid Res. 48: 1781-1791 (2007).
*
-
Doukhanina EV, Apuya NR, Yoo HD, Wu CY, Davidow P, Krueger S, Flavell RB, Hamilton R, Bobzin SC. Expression of human nuclear receptors in plants for the discovery of plant-derived ligands.
J. Biomol. Screen. 12: 385-395 (2007).
-
Down MJ, Arkle S, Mills JJ. Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6J mouse liver.
Arch. Biochem. Biophys. 457: 105-110 (2007).
*
-
Downie MM, Sanders DA, Maier LM, Stock DM, Kealey T. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.
Br. J. Dermatol. 151: 766-775 (2004).
*
-
Doyle DF, Braasch DA, Jackson LK, Weiss HE, Boehm MF, Mangelsdorf DJ, Corey DR. Engineering orthogonal ligand-receptor pairs from "near drugs".
J. Am. Chem. Soc. 123: 11367-11371 (2001).
*
-
Doyon G, St-Jean S, Darsigny M, Asselin C, Boudreau F. Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal cells in culture and down-modulates the expression of pigment-epithelial-derived factor.
J. Biol. Chem. 284: 25220-25229 (2009).
*
-
Drew PD, Storer PD, Xu J, Chavis JA. Hormone regulation of microglial cell activation: relevance to multiple sclerosis.
Brain Res. Brain Res. Rev. 48: 322-327 (2005).
-
Druilhe A, Zahm JM, Benayoun L, El Mehdi D, Grandsaigne M, Dombret MC, Mosnier I, Feger B, Depondt J, Aubier M, Pretolani M. Epithelium expression and function of retinoid receptors in asthma.
Am. J. Respir. Cell. Mol. Biol. 38: 276-282 (2008).
*
-
Du X, Tabeta K, Mann N, Crozat K, Mudd S, Beutler B. An essential role for Rxr alpha in the development of Th2 responses.
Eur. J. Immunol. 35: 3414-3423 (2005).
*
-
Duane WC, Xiong W, Lofgren J. Transactivation of the human apical sodium-dependent bile acid transporter gene by human serum.
J. Steroid Biochem. Mol. Biol. 108: 137-148 (2008).
-
Duane WC, Xiong W, Wolvers J. Effects of bile acids on expression of the human apical sodium dependent bile acid transporter gene.
Biochim. Biophys. Acta 1771: 1380-1388 (2007).
*
-
Dubuquoy L, Dharancy S, Nutten S, Pettersson S, Auwerx J, Desreumaux P. Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases.
Lancet 360: 1410-1418 (2002).
*
-
Duell EA, Astrom A, Griffiths CE, Chambon P, Voorhees JJ. Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro.
J. Clin. Invest. 90: 1269-1274 (1992).
*
-
Duncan RE, Archer MC. Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes.
Lipids 43: 619-627 (2008).
-
Dunlop TW, Vaisanen S, Frank C, Molnar F, Sinkkonen L, Carlberg C. The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D(3) and its nuclear receptor.
J. Mol. Biol. 349: 248-260 (2005).
*
-
Dushkin MI, Khoshchenko OM, Chasovsky MA, Pivovarova EN. The content of PPAR, LXR, and RXR and the PPAR DNA-binding activity in macrophages over the course of inflammation in mice.
Bull. Exp. Biol. Med. 147: 345-348 (2009).
-
Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottee L, Bieche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Decleves X, Duyckaerts C, Loriot MA. Xenobiotic metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.
Drug Metab. Dispos. 37: 1528-1538 (2009).
*
-
Duttaroy AK. Transport of fatty acids across the human placenta: a review.
Prog. Lipid Res. 48: 52-61 (2009).
*
-
Dzhagalov I, Chambon P, He YW. Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma.
J. Immunol. 178: 2113-2121 (2007).
*
-
Eager NS, Brickell PM, Snell C, Wood JN. Structural and functional evidence for activation of a chick retinoid X receptor by eicosanoids.
Proc. Biol. Sci. 250: 63-69 (1992).
*
-
Ebert R, Schutze N, Adamski J, Jakob F. Vitamin D signaling is modulated on multiple levels in health and disease.
Mol. Cell. Endocrinol. 248: 149-159 (2006).
-
Echchgadda I, Song CS, Oh TS, Cho SH, Rivera OJ, Chatterjee B. Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).
Mech. Ageing Dev. 125: 733-745 (2004).
-
Echchgadda I, Song CS, Roy AK, Chatterjee B. Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.
Mol. Pharmacol. 65: 720-729 (2004).
*
-
Edwards PA, Kennedy MA, Mak PA. LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis.
Vascul. Pharmacol. 38: 249-256 (2002).
*
-
Egan JB, Thompson PA, Ashbeck EL, Conti DV, Duggan D, Hibler E, Jurutka PW, Leroy EC, Martinez ME, Mount D, Jacobs ET. Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence.
Cancer Res. 70: 1496-1504 (2010).
*
-
Egea PF, Mitschler A, Moras D. Molecular recognition of agonist ligands by RXRs.
Mol. Endocrinol. 16: 987-997 (2002).
*
-
Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.
EMBO J. 19: 2592-2601 (2000).
*
-
Egea PF, Rochel N, Birck C, Vachette P, Timmins PA, Moras D. Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR.
J. Mol. Biol. 307: 557-576 (2001).
*
-
Elizondo G, Medina-Diaz IM, Cruz R, Gonzalez FJ, Vega L. Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction.
Biochem. Pharmacol. 77: 248-257 (2009).
*
-
Ellison TI, Eckert RL, Macdonald PN. Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes.
J. Biol. Chem. 282: 10953-10962 (2007).
*
-
Eloranta JJ, Hiller C, Hausler S, Stieger B, Kullak-Ublick GA. Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter.
Mol. Pharmacol. 76: 1062-1071 (2009).
-
Emamian ES, Leon JM, Lessard CJ, Grandits M, Baechler EC, Gaffney PM, Segal B, Rhodus NL, Moser KL. Peripheral blood gene expression profiling in Sjogren's syndrome.
Genes Immun. 10: 285-296 (2009).
*
-
Endo T, Imanishi T, Gojobori T, Inoko H. Evolutionary significance of intra-genome duplications on human chromosomes.
Gene 205: 19-27 (1997).
-
Engel T, Lorkowski S, Lueken A, Rust S, Schluter B, Berger G, Cullen P, Assmann G. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages.
Biochem. Biophys. Res. Commun. 288: 483-488 (2001).
*
-
Erichsen TJ, Aehlen A, Ehmer U, Kalthoff S, Manns MP, Strassburg CP. Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids.
J. Hepatol. [In Press] (2010).
-
Ertesvag A, Engedal N, Naderi S, Blomhoff HK. Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion.
J. Immunol. 169: 5555-5563 (2002).
*
-
Faist F, Short S, Kneale G, Sharpe CR. Alternative splicing determines the interaction of SMRT isoforms with nuclear receptor-DNA complexes.
Biosci. Rep. 29: 143-149 (2009).
-
Falkner KC, Pinaire JA, Xiao GH, Geoghegan TE, Prough RA. Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors.
Mol. Pharmacol. 60: 611-619 (2001).
*
-
Fan W, Yanase T, Morinaga H, Mu YM, Nomura M, Okabe T, Goto K, Harada N, Nawata H. Activation of peroxisome proliferator activated receptor gamma and retinoid X receptor inhibits aromatase transcription via NF-kappaB.
Endocrinology 146: 85-92 (2005).
*
-
Fan X, Roy EM, Murphy TC, Nanes MS, Kim S, Pike JW, Rubin J. Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells.
J. Cell. Biochem. 93: 807-818 (2004).
*
-
Fan YY, Spencer TE, Wang N, Moyer MP, Chapkin RS. Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes.
Carcinogenesis 24: 1541-1548 (2003).
*
-
Fang C, Yoon S, Tindberg N, Jarvelainen HA, Lindros KO, Ingelman-Sundberg M. Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure.
Biochem. Pharmacol. 67: 1389-1397 (2004).
*
-
Farmer LJ, Marron KS, Canan Koch SS, Hwang CK, Kallel EA, Zhi L, Nadzan AM, Robertson DW, Bennani YL. Aza-retinoids as novel retinoid X receptor-specific agonists.
Bioorg. Med. Chem. Lett. 16: 2352-2356 (2006).
*
-
Farmer PK, He X, Schmitz ML, Rubin J, Nanes MS. Inhibitory effect of NF-kappaB on 1,25-dihydroxyvitamin D(3) and retinoid X receptor function.
Am. J. Physiol. Endocrinol. Metab. 279: E213-E220 (2000).
*
-
Feart C, Mingaud F, Enderlin V, Husson M, Alfos S, Higueret P, Pallet V. Differential effect of retinoic acid and triiodothyronine on the age-related hypo-expression of neurogranin in rat.
Neurobiol. Aging 26: 729-738 (2005).
-
Feige JN, Gelman L, Tudor C, Engelborghs Y, Wahli W, Desvergne B. Fluorescence imaging reveals the nuclear behavior of PPAR/RXR heterodimers in the absence and presence of ligand.
J. Biol. Chem. 280: 17880-17890 (2005).
*
-
Feingold K, Kim MS, Shigenaga J, Moser A, Grunfeld C. Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response.
Am. J. Physiol. Endocrinol. Metab. 286: E201-E207 (2004).
*
-
Feingold KR, Moser A, Patsek SM, Shigenaga JK, Grunfeld C. Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm.
J. Lipid Res. May 14 [Epub ahead of print] (2009).
*
-
Feng J, Chen J, Yan J, Jones IR, Craddock N, Cook EH Jr, Goldman D, Heston LL, Sommer SS. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.
Am. J. Med. Genet. B. Neuropsychiatr. Genet. 133B: 50-53 (2005).
*
-
Feng S, Lin L, Wu Q, Zhou W, Shao C. Study on the expression of RXRalpha in patients with psoriasis vulgaris.
Eur. J. Dermatol. 16: 33-38 (2006).
*
-
Feng X, Peng ZH, Di W, Li XY, Rochette-Egly C, Chambon P, Voorhees JJ, Xiao JH. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids.
Genes Dev. 11: 59-71 (1997).
*
-
Fernandez-Martin JL, Kurian S, Farmer P, Nanes MS. Tumor necrosis factor activates a nuclear inhibitor of vitamin D and retinoid-X receptors.
Mol. Cell. Endocrinol. 141: 65-72 (1998).
-
Field FJ, Born E, Mathur SN. LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells.
J. Lipid Res. 45: 905-913 (2004).
*
-
Figueira AC, Dias SM, Santos MA, Apriletti JW, Baxter JD, Webb P, Neves FA, Simeoni LA, Ribeiro RC, Polikarpov I. Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.
Cell. Biochem. Biophys. 44: 453-462 (2006).
-
Figueira AC, Neto MD, Bernardes A, Dias SM, Craievich AF, Baxter JD, Webb P, Polikarpov I. Low-resolution structures of thyroid hormone receptor dimers and tetramers in solution.
Biochemistry 46: 1273-1283 (2007).
*
-
Fiorucci S. FXR and liver fibrosis.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 67-69 (2006). *
-
Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.
J. Biol. Chem. 278: 27997-28004 (2003).
*
-
Fitzgerald ML, Moore KJ, Freeman MW. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.
J. Mol. Med. 80: 271-281 (2002).
*
-
Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S. Mapping of RXRB to human chromosome 6p21.3.
Ann. Hum. Genet. 57: 203-209 (1993).
-
Flores AM, Li L, Aneskievich BJ. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator.
J. Invest. Dermatol. 123: 1092-1101 (2004).
*
-
Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski CM, Ntambi JM, Attie AD. Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet.
Physiol. Genomics 33: 361-372 (2008).
*
-
Folkertsma S, van Noort PI, de Heer A, Carati P, Brandt R, Visser A, Vriend G, de Vlieg J. The use of in vitro peptide binding profiles and in silico ligand-receptor interaction profiles to describe ligand-induced conformations of the retinoid X receptor alpha ligand-binding domain.
Mol. Endocrinol. 21: 30-48 (2007).
*
-
Fonzo LS, Golini RS, Delgado SM, Ponce IT, Bonomi MR, Rezza IG, Gimenez MS, Anzulovich AC. Temporal patterns of lipoperoxidation and antioxidant enzymes are modified in the hippocampus of vitamin A-deficient rats.
Hippocampus 19: 869-880 (2009).
-
Fouassier L, Beaussier M, Schiffer E, Rey C, Barbu V, Mergey M, Wendum D, Callard P, Scoazec JY, Lasnier E, Stieger B, Lienhart A, Housset C. Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes.
Am. J. Physiol. Gastrointest. Liver Physiol. 293: G25-G35 (2007).
*
-
Frank C, Gonzalez MM, Oinonen C, Dunlop TW, Carlberg C. Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor.
J. Biol. Chem. 278: 43299-43310 (2003).
*
-
Frank C, Makkonen H, Dunlop TW, Matilainen M, Vaisanen S, Carlberg C. Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis.
J. Mol. Biol. 346: 505-519 (2005).
*
-
Freedman LP, Arce V, Perez Fernandez R. DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.
Mol. Endocrinol. 8: 265-273 (1994).
-
Fretz JA, Zella LA, Kim S, Shevde NK, Pike JW. 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription.
Mol. Endocrinol. 20: 2215-2230 (2006).
*
-
Friedmann PS, Cooper HL, Healy E. Peroxisome proliferator-activated receptors and their relevance to dermatology.
Acta Derm. Venereol. 85: 194-202 (2005).
*
-
Friling S, Bergsland M, Kjellander S. Activation of retinoid X receptor increases dopamine cell survival in models for Parkinson's disease.
BMC Neurosci. 10: 146 (2009).
*
-
Fu J, Ding Y, Huang D, Li H, Chen X. The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer.
Cancer Lett. 248: 153-163 (2007).
*
-
Fu L, Tomita A, Wang H, Buchholz DR, Shi YB. Transcriptional regulation of the Xenopus laevis stromelysin-3 gene by thyroid hormone is mediated by a DNA element in the first intron.
J. Biol. Chem. 281: 16870-16878 (2006).
*
-
Fujishita K, Koizumi S, Inoue K. Upregulation of P2Y2 receptors by retinoids in normal human epidermal keratinocytes.
Purinergic Signal. 2: 491-498 (2006).
*
-
Fujita A, Mitsuhashi T. Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.
Biochem. Biophys. Res. Commun. 255: 625-630 (1999).
*
-
Fukasawa H, Kagechika H, Shudo K. Retinoid therapy for autoimmune diseases.
Nihon Rinsho Meneki Gakkai Kaishi 29: 114-126 (2006).
*
-
Galdones E, Hales BF. Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.
Toxicol. Sci. 106: 223-232 (2008).
*
-
Galdones E, Lohnes D, Hales BF. Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro.
Birth Defects Res. A. Clin. Mol. Teratol. 76: 39-45 (2006).
-
Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.
J. Biol. Chem. 276: 68-75 (2001).
*
-
Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Mol. Cell 5: 545-555 (2000).
*
-
Gampe RT Jr, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Genes Dev. 14: 2229-2241 (2000).
*
-
Gani OA, Sylte I. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha.
J. Mol. Graph Model. 27: 217-224 (2008).
*
-
García J, Khanwalkar H, Pereira R, Erb C, Voegel JJ, Collette P, Mauvais P, Bourguet W, Gronemeyer H, de Lera AR. Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors.
Chembiochem. 10: 1252-1259 (2009).
*
-
Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation.
J. Immunol. 183: 6903-6912 (2009).
-
Garnock-Jones KP, Perry CM. Alitretinoin: in severe chronic hand eczema.
Drugs 69: 1625-1634 (2009).
-
Gbaguidi GF, Agellon LB. The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter.
Biochim. Biophys. Acta 1583: 229-236 (2002).
*
-
Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, Suchy FJ, Matern S, Gartung C. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver.
Am. J. Physiol. Gastrointest. Liver Physiol. 289: G831-G841 (2005).
*
-
Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Hepatology 38: 345-354 (2003).
*
-
Geier A, Kim SK, Gerloff T, Dietrich CG, Lammert F, Karpen SJ, Stieger B, Meier PJ, Matern S, Gartung C. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride.
J. Hepatol. 37: 198-205 (2002).
*
-
Geier A, Martin IV, Dietrich CG, Balasubramaniyan N, Strauch S, Suchy FJ, Gartung C, Trautwein C, Ananthanarayanan M. Hepatocyte nuclear factor 4alpha is a central transactivator of the mouse Ntcp gene.
Am. J. Physiol. Gastrointest. Liver Physiol. 295: G226-G233 (2008).
*
-
Geier A, Zollner G, Dietrich CG, Wagner M, Fickert P, Denk H, van Rooijen N, Matern S, Gartung C, Trauner M. Cytokine-independent repression of rodent Ntcp in obstructive cholestasis.
Hepatology 41: 470-477 (2005).
*
-
Geissmann F, Revy P, Brousse N, Lepelletier Y, Folli C, Durandy A, Chambon P, Dy M. Retinoids regulate survival and antigen presentation by immature dendritic cells.
J. Exp. Med. 198: 623-634 (2003).
*
-
Gentili C, Tutolo G, Pianezzi A, Cancedda R, Descalzi Cancedda F. Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression.
Matrix Biol. 24: 35-44 (2005).
-
George TN, Snyder JM. Regulation of surfactant protein gene expression by retinoic acid metabolites.
Pediatr. Res. 41: 692-701 (1997).
-
Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LXIII. Retinoid X receptors.
Pharmacol. Rev. 58: 760-772 (2006).
*
-
Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Integration of nuclear receptors and cell signaling pathways on bile acid physiology.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 44. June 18-19 (2004). *
-
Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid.
Arch. Biochem. Biophys. 481: 123-130 (2009).
*
-
Ghose R, Mulder J, von Furstenberg RJ, Thevananther S, Kuipers F, Karpen SJ. Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver.
J. Hepatol. 46: 115-123 (2007).
*
-
Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of TIR-domain containing adaptor protein (TIRAP).
Drug Metab. Dispos. 36: 95-101 (2008).
*
-
Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: a novel mechanism for reduced hepatic gene expression in inflammation.
Nucl. Recept. 2: 4 (2004).
*
-
Ghosh JC, Yang X, Zhang A, Lambert MH, Li H, Xu HE, Chen JD. Interactions that determine the assembly of a retinoid X receptor/corepressor complex.
Proc. Natl. Acad. Sci. U.S.A. 99: 5842-5847 (2002).
*
-
Ghyselinck NB, Chapellier B, Calleja C, Kumar Indra A, Li M, Messaddeq N, Mark M, Metzger D, Chambon P. Genetic dissection of retinoic acid function in epidermis physiology.
Ann. Dermatol. Venereol. 129: 793-799 (2002).
-
Giaginis C, Katsamangou E, Tsourouflis G, Zizi-Serbetzoglou D, Kouraklis G, Theocharis S. Peroxisome proliferator-activated receptor-gamma and retinoid X receptor-alpha expression in pancreatic ductal adenocarcinoma: association with clinicopathological parameters, tumor proliferative capacity, and patients' survival.
Med. Sci. Monit. 15: BR148-BR156 (2009).
-
Gianni M, Zanotta S, Terao M, Garattini S, Garattini E. Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells.
Biochem. Biophys. Res. Commun. 196: 252-259 (1993).
*
-
Gill RK, Atkins LM, Hollis BW, Bell NH. Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1.
Mol. Endocrinol. 12: 57-65 (1998).
*
-
Gillespie RF, Gudas LJ. Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells.
J. Mol. Biol. 372: 298-316 (2007).
*
-
Gillio-Meina C, Phang S, Mather J, Knight B, Kennedy T. Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta (PPARD) and retinoid X receptor alpha (RXRA) in rat …
Reproduction 137: 537-552 (2009).
-
Golden WM, Weber KB, Hernandez TL, Sherman SI, Woodmansee WW, Haugen BR. Single-dose rexinoid rapidly and specifically suppresses serum thyrotropin in normal subjects.
J. Clin. Endocrinol. Metab. 92: 124-130 (2007).
*
-
Goldstein JT, Dobrzyn A, Clagett-Dame M, Pike JW, DeLuca HF. Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor.
Arch. Biochem. Biophys. 420: 185-193 (2003).
*
-
Gombart AF, Luong QT, Koeffler HP. Vitamin D compounds: activity against microbes and cancer.
Anticancer Res. 26: 2531-2542 (2006).
-
Gomes-Alves P, Couto F, Pesquita C, Coelho AV, Penque D. Rescue of F508del-CFTR by RXR-motif inactivation triggers proteome modulation associated with the unfolded protein response.
Biochim. Biophys. Acta Dec 28 [Epub ahead of print] (2009).
*
-
Gong H, Xie W. Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential.
Expert Opin. Ther. Targets 8: 49-54 (2004).
-
Gongora R, Zaleska-Rutczynska Z, Takami K, Figueroa F, Klein J. Linkage of RXRB-like genes to class I and not to class II MHC genes in the zebrafish.
Immunogenetics 48: 141-143 (1998).
-
Gonzalez FJ. Recent update on the PPAR alpha-null mouse.
Biochimie 79: 139-144 (1997).
-
Gonzalez MM, Carlberg C. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
J. Biol. Chem. 277: 18501-18509 (2002).
*
-
Gorgun G, Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox.
Blood 100: 1399-1403 (2002).
*
-
Gorla-Bajszczak A, Juge-Aubry C, Pernin A, Burger AG, Meier CA. Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.
Mol. Cell. Endocrinol. 147: 37-47 (1999).
-
Gorodeski GI, Eckert RL, Pal D, Utian WH, Rorke EA. Retinoids regulate tight junctional resistance of cultured human cervical cells.
Am. J. Physiol. 273: C1707-C1713 (1997).
*
-
Gotoh S, Ohgari Y, Nakamura T, Osumi T, Taketani S. Heme-binding to the nuclear receptor retinoid X receptor alpha (RXRalpha) leads to the inhibition of the transcriptional activity.
Gene 423: 207-214 (2008).
*
-
Gouni-Berthold I, Krone W. Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis.
Curr. Drug Targets Cardiovasc. Haematol. Disord. 5: 513-523 (2005).
-
Green S. PPAR: a mediator of peroxisome proliferator action.
Mutat. Res. 333: 101-109 (1995).
-
Green S, Wahli W. Peroxisome proliferator-activated receptors: finding the orphan a home.
Mol. Cell. Endocrinol. 100: 149-153 (1994).
*
-
Greger DL, Gropp F, Morel C, Sauter S, Blum JW. Nuclear receptor and target gene mRNA abundance in duodenum and colon of dogs with chronic enteropathies.
Domest. Anim. Endocrinol. 31: 327-329 (2006).
*
-
Greger DL, Philipona C, Blum JW. Ontogeny of mRNA abundance of nuclear receptors and nuclear receptor target genes in young cattle.
Domest. Anim. Endocrinol. 31: 76-87 (2006).
*
-
Grenier E, Schwalm Maupas F, Beaulieu JF, Seidman EG, Delvin E, Sane AT, Tremblay E, Garofalo C, Levy E. Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion and apolipoprotein biogenesis.
Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1178-G1189 (2007).
*
-
Grenningloh R, Gho A, di Lucia P, Klaus M, Bollag W, Ho IC, Sinigaglia F, Panina-Bordignon P. Cutting edge: inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation.
J. Immunol. 176: 5161-5166 (2006).
*
-
Griffin MD, Dong X, Kumar R. Vitamin D receptor-mediated suppression of RelB in antigen presenting cells: a paradigm for ligand-augmented negative transcriptional regulation.
Arch. Biochem. Biophys. 460: 218-226 (2007).
*
-
Grober J, Zaghini I, Fujii H, Jones SA, Kliewer SA, Willson TM, Ono T, Besnard P. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer.
J. Biol. Chem. 274: 29749-29754 (1999).
*
-
Gropp FN, Greger DL, Morel C, Sauter S, Blum JW. Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs.
J. Anim. Sci. 84: 2684-2691 (2006).
*
-
Grun F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.
Endocrinology 147: S50-S55 (2006).
*
-
Grun F, Blumberg B. Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis.
Rev. Endocr. Metab. Disord. 8: 161-171 (2007).
*
-
Grun F, Watanabe H, Zamanian Z, Maeda L, Arima K, Chubacha R, Gardiner DM, Kanno J, Iguchi T, Blumberg B. Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates.
Mol. Endocrinol. 20: 2141-2155 (2006).
*
-
Gu X, Ke S, Liu D, Sheng T, Thomas PE, Rabson AB, Gallo MA, Xie W, Tian Y. Role of NF-kappa B in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P450 3A4 by proinflammatory agents.
J. Biol. Chem. 281: 17882-17889 (2006).
*
-
Gui Y, Cai Z, Silha JV, Murphy LJ. Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha.
Can. J. Physiol. Pharmacol. 84: 887-892 (2006).
-
Guo GL, Staudinger J, Ogura K, Klaassen CD. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Mol. Pharmacol. 61: 832-839 (2002).
*
-
Guo M, Gong L, He L, Lehman-McKeeman L, Wan YJ. Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner.
BMC Genomics 9: 403 (2008).
*
-
Gupta D, Jetton TL, Mortensen RM, Zhong Duan S, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse PDX-1 promoter.
J. Biol. Chem. 283: 32462-32470 (2008).
*
-
Gustafsson MC, Knight D, Palmer CN. Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.
PLoS One 4: e7046 (2009).
*
-
Gutierrez S, Liu J, Javed A, Montecino M, Stein GS, Lian JB, Stein JL. The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain.
J. Biol. Chem. 279: 43581-43588 (2004).
*
-
Gyamfi MA, He L, French SW, Damjanov I, Wan YJ. Hepatocyte retinoid X receptor alpha-dependent regulation of lipid homeostasis and inflammatory cytokine expression contributes to alcohol-induced liver injury.
J. Pharmacol. Exp. Ther. 324: 443-453 (2008).
*
-
Gyamfi MA, Kocsis MG, He L, Dai G, Mendy AJ, Wan YJ. The role of retinoid X receptor alpha in regulating alcohol metabolism.
J. Pharmacol. Exp. Ther. 319: 360-368 (2006).
*
-
Gyamfi MA, Wan YJ. Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
J. Biol. Chem. 284: 9321-9330 (2009).
*
-
Hallenbeck PL, Marks MS, Lippoldt RE, Ozato K, Nikodem VM. Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.
Proc. Natl. Acad. Sci. U.S.A. 89: 5572-5576 (1992).
*
-
Hamza MS, Pott S, Vega VB, Thomsen JS, Kandhadayar GS, Ng PW, Chiu KP, Pettersson S, Wei CL, Ruan Y, Liu ET. De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis.
PLoS ONE 4: e4907 (2009).
*
-
Han K, Song H, Moon I, Augustin R, Moley K, Rogers M, Lim H. Utilization of DR1 as true RARE in regulating the Ssm, a novel retinoic acid-target gene in the mouse testis.
J. Endocrinol. 192: 539-551 (2007).
*
-
Han S, Chiang JY. Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Drug Metab. Dispos. 37: 469-478 (2009).
*
-
Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, Zhang XK. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations.
J. Biol. Chem. 284: 18503-18514 (2009).
*
-
Hance KW, Rogers CJ, Hursting SD, Greiner JW. Combination of physical activity, nutrition, or other metabolic factors and vaccine response.
Front. Biosci. 12: 4997-5029 (2007).
-
Handschin C, Meyer UA. Induction of drug metabolism: the role of nuclear receptors.
Pharmacol. Rev. 55: 649-673 (2003).
*
-
Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM, Williams ML, Feingold KR. Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier.
J. Clin. Invest. 100: 705-712 (1997).
*
-
Harada H, Miki R, Masushige S, Kato S. Gene expression of retinoic acid receptors, retinoid-X receptors, and cellular retinol-binding protein I in bone and its regulation by vitamin A.
Endocrinology 136: 5329-5335 (1995).
-
Haraguchi G, Suzuki JI, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M. A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
J. Mol. Cell. Cardiol. 41: 885-892 (2006).
*
-
Harder ME, Malencik DA, Yan X, Broderick D, Leid M, Anderson SR, Deinzer ML, Schimerlik MI. Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate.
Biophys. Chem. 141: 1-10 (2009).
*
-
Harish S, Ashok MS, Khanam T, Rangarajan PN. Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function.
Biochem. Biophys. Res. Commun. 279: 853-857 (2000).
*
-
Harmon MA, Boehm MF, Heyman RA, Mangelsdorf DJ. Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.
Proc. Natl. Acad. Sci. U.S.A. 92: 6157-6160 (1995).
*
-
Haruta I, Hashimoto E, Shibata N, Kato Y, Kobayashi M, Shiratori K. Lipoteichoic acid may affect the pathogenesis of PBC-like bile duct damage and might be involved in systemic multifocal epithelial inflammations in chronic colitis-harboring TCRalpha-/-xAIM-/- mice.
Autoimmunity 40: 372-379 (2007).
*
-
Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, Mori M, Wondisford FE. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model.
J. Biol. Chem. 281: 295-302 (2006).
*
-
Hashimoto K, Matsumoto S, Yamada M, Satoh T, Mori M. Liver X receptor alpha gene expression is positively regulated by thyroid hormone.
Endocrinology 148: 4667-4675 (2007).
*
-
Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M. Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone.
Endocrinology 147: 4292-4302 (2006).
*
-
Hashimoto T, Shimizu N, Kimura T, Takahashi Y, Ide T. Polyunsaturated fats attenuate the dietary phytol-induced increase in hepatic fatty acid oxidation in mice.
J. Nutr. 136: 882-886 (2006).
*
-
Hashimoto Y, Miyachi H. Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.
Bioorg. Med. Chem. 13: 5080-5093 (2005).
*
-
Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC. Type 2 diabetes susceptibility genes on chromosome 1q21-24.
Ann. Hum. Genet. 72: 163-169 (2008).
*
-
Haugen BR, Jensen DR, Sharma V, Pulawa LK, Hays WR, Krezel W, Chambon P, Eckel RH. Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet.
Endocrinology 145: 3679-3685 (2004).
*
-
Haussler MR, Haussler CA, Bartik L, Whitfield GK, Hsieh JC, Slater S, Jurutka PW. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.
Nutr. Rev. 66: S98-S112 (2008).
*
-
Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK. The vitamin D hormone and its nuclear receptor: molecular actions and disease states.
J. Endocrinol. 154: S57-S73 (1997).
*
-
Haussler MR, Jurutka PW, Hsieh JC, Thompson PD, Selznick SH, Haussler CA, Whitfield GK. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone.
Bone 17: 33S-38S (1995).
-
He C, Wang C, Li B, Xie F, Chen Y, Zuo Z. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus.
Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 154: 221-228 (2009).
*
-
He FL, Wang L, Zhang XK, Zeng JZ. Emodin induces apoptosis of cancer cells and inhibits retinoid X receptor transcriptional activity.
Yao Xue Xue Bao 43: 350-355 (2008).
-
Heckmann M, Holle JU, Arning L, Knaup S, Hellmich B, Nothnagel M, Jagiello P, Gross WL, Epplen JT, Wieczorek S. The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterized by tagSNP genotyping.
Ann. Rheum. Dis. 67: 972-979 (2008).
-
Heery DM, Zacharewski T, Pierrat B, Gronemeyer H, Chambon P, Losson R. Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.
Proc. Natl. Acad. Sci. U.S.A. 90: 4281-4285 (1993).
*
-
Hegedus T, Aleksandrov A, Cui L, Gentzsch M, Chang XB, Riordan JR. F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.
Biochim. Biophys. Acta 1758: 565-572 (2006).
*
-
Hegele RA. Retinoid X receptor heterodimers in the metabolic syndrome.
N. Engl. J. Med. 353: 2088 (2005).
*
-
Hegele RA, Cao H. Single nucleotide polymorphisms of RXRA encoding retinoid X receptor alpha.
J. Hum. Genet. 46: 423-425 (2001).
*
-
Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P, Pipeleers D. Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.
FEBS J. 274: 6094-6105 (2007).
*
-
Hellemans K, Verbuyst P, Quartier E, Schuit F, Rombouts K, Chandraratna RA, Schuppan D, Geerts A. Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids.
Hepatology 39: 97-108 (2004).
*
-
Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C. 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor.
Cell 68: 397-406 (1992).
*
-
Higashiyama H, Kinoshita M, Asano S. Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray.
Acta Histochem. 110: 86-93 (2008).
-
Higgins LS, Depaoli AM. Selective peroxisome proliferator-activated receptor gamma (PPARgamma) modulation as a strategy for safer therapeutic PPARgamma activation.
Am. J. Clin. Nutr. 91: 267S-272S (2010).
*
-
Hirotani M, Tsukamoto T, Bourdeaux J, Sadano H, Osumi T. Stabilization of peroxisome proliferator-activated receptor alpha by the ligand.
Biochem. Biophys. Res. Commun. 288: 106-110 (2001).
*
-
Hoeke MO, Plass JR, Heegsma J, Geuken M, van Rijsbergen D, Baller JF, Kuipers F, Moshage H, Jansen PL, Faber KN. Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.
Hepatology 49: 151-159 (2009).
*
-
Hoftijzer H, Liu Y, Morreau H, Van Wezel T, Pereira A, Corssmit E, Romijn J, Smit J. Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms.
Eur. J. Endocrinol. 160: 631-638 (2009).
-
Holdsworth-Carson S, Lim R, Mitton A, Whitehead C, Rice G, Permezel M, Lappas M. Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia.
Placenta Dec 30 [Epub ahead of print] (2009).
-
Holdsworth-Carson S, Permezel M, Rice G, Lappas M. Preterm and infection-driven preterm labour: the role of peroxisome proliferator-activated receptors and retinoid X receptor.
Reproduction 137: 1007-1015 (2009).
-
Holdsworth-Carson SJ, Permezel M, Riley C, Rice GE, Lappas M. Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes.
Placenta 30: 176-186 (2009).
-
Hong JS, Kim SW, Koo JS. Sp1 upregulates cAMP response element-binding protein expression during retinoic acid-induced mucous differentiation of normal human bronchial epithelial cells.
Biochem. J. 410: 49-61 (2008).
*
-
Hong SE, Ahn IS, Jung HS, Rayner DV, Do MS. Effect of retinoic acid on leptin, glycerol, and glucose levels in mature rat adipocytes in vitro.
J. Med. Food 7: 320-326 (2004).
-
Honkakoski P, Zelko I, Sueyoshi T, Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.
Mol. Cell. Biol. 18: 5652-5658 (1998).
*
-
Hoo RL, Chan KY, Leung FK, Lee LT, Leung PC, Chow BK. Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene.
FEBS J. 274: 2695-2706 (2007).
*
-
Hoopes CW, Taketo M, Ozato K, Liu Q, Howard TA, Linney E, Seldin MF. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.
Genomics 14: 611-617 (1992).
-
Hoover LL, Burton EG, O'Neill ML, Brooks BA, Sreedharan S, Dawson NA, Kubalak SW. Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation.
Biochim. Biophys. Acta 1783: 2279-2286 (2008).
*
-
Hopkins PM, Durica D, Washington T. RXR isoforms and endogenous retinoids in the fiddler crab, Uca pugilator.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 151: 602-614 (2008).
*
-
Horiguchi T, Ohta Y, Nishikawa T, Shiraishi F, Shiraishi H, Morita M. Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell, Thais clavigera.
Cell. Biol. Toxicol. 24: 553-562 (2008).
*
-
Hou L, Lu C, Huang Y, Chen S, Hua L, Qian R. Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice.
Lipids Health Dis. 8: 60 (2009).
*
-
Hou Z, Peng H, White DE, Negorev DG, Maul GG, Feng Y, Longmore GD, Waxman S, Zelent A, Rauscher FJ 3rd. LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.
Proc. Natl. Acad. Sci. U.S.A. Jan 26 [Epub ahead of print] (2010).
*
-
Howell SR, Shirley MA, Ulm EH. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid X receptor selectivity and effects on metabolic enzymes.
Drug Metab. Dispos. 26: 234-239 (1998).
*
-
Hozoji M, Munehira Y, Ikeda Y, Makishima M, Matsuo M, Kioka N, Ueda K. Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux.
J. Biol. Chem. 283: 30057-30063 (2008).
*
-
Hsieh CH, Liang KH, Hung YJ, Huang LC, Pei D, Liao YT, Kuo SW, Bey MS, Chen JL, Chen EY. Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients.
Hum. Mol. Genet. 15: 2701-2708 (2006).
*
-
Hsieh JC, Dang HT, Galligan MA, Whitfield GK, Haussler CA, Jurutka PW, Haussler MR. Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)(2)D(3)-dependent transactivation.
Biochem. Biophys. Res. Commun. 324: 801-809 (2004).
*
-
Hsieh JC, Nakajima S, Galligan MA, Jurutka PW, Haussler CA, Whitfield GK, Haussler MR. Receptor mediated genomic action of the 1,25(OH)2D3 hormone: expression of the human vitamin D receptor in E. coli.
J. Steroid Biochem. Mol. Biol. 53: 583-594 (1995).
-
Hu T, Chouinard M, Cox AL, Sipes P, Marcelo M, Ficorilli J, Li S, Gao H, Ryan TP, Michael MD, Michael LF. Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.
J. Biol. Chem. 281: 39831-39838 (2006).
*
-
Hu X, Funder JW. The evolution of mineralocorticoid receptors.
Mol. Endocrinol. 20: 1471-1478 (2006).
*
-
Huan B, Siddiqui A. Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer.
Proc. Natl. Acad. Sci. U.S.A. 89: 9059-9063 (1992).
*
-
Huang J, Bi Y, Zhu GH, He Y, Su Y, He BC, Wang Y, Kang Q, Chen L, Zuo GW, Luo Q, Shi Q, Zhang BQ, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N. Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.
Liver Int. 29: 1569-1581 (2009).
*
-
Huang JC. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos.
PPAR Res. 2008: 732303 (2008).
*
-
Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, de Pedro N, Royo I, Blevins RA, Pelaez F, Wright SD, Cui J. Farnesoid X receptor activates transcription of the phospholipid pump MDR3.
J. Biol. Chem. 278: 51085-51090 (2003).
*
-
Huang S, Laoukili J, Epping MT, Koster J, Holzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
Cancer Cell 15: 328-340 (2009).
-
Hughes PJ, Brown G. 1alpha,25-Dihydroxyvitamin D(3)-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDR(nuc)-mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway.
J. Cell. Biochem. 98: 590-617 (2006).
*
-
Hughes PJ, Zhao Y, Chandraratna RA, Brown G. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
J. Cell. Biochem. 97: 327-350 (2006).
*
-
Humar B, D'Orazio D, Albrecht C, Bauerfeind P, Muller H, Dobbie Z, Bendik I. Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status.
Int. J. Oncol. 19: 1179-1186 (2001).
-
Hummasti S, Tontonoz P. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.
J. Lipid Res. 49: 2535-2544 (2008).
*
-
Hunt MC, Yang YZ, Eggertsen G, Carneheim CM, Gafvels M, Einarsson C, Alexson SE. The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis.
J. Biol. Chem. 275: 28947-28953 (2000).
*
-
Hunter J, Kassam A, Winrow CJ, Rachubinski RA, Capone JP. Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes.
Mol. Cell. Endocrinol. 116: 213-221 (1996).
-
Huq MD, Ha SG, Wei LN. Modulation of retinoic acid receptor alpha activity by lysine methylation in the DNA binding domain.
J. Proteome Res. 7: 4538-4545 (2008).
*
-
Huq MM, Tsai NP, Khan SA, Wei LN. Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function.
Mol. Cell. Proteomics 6: 677-688 (2007).
*
-
Huss JM, Kasper CB. Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors.
Mol. Pharmacol. 58: 48-57 (2000).
*
-
Hutchins H. Omega-3 fatty acids: recommendations for therapeutics and prevention.
MedGenMed. 7: 18 (2005).
*
-
Huuskonen J, Vishnu M, Fielding PE, Fielding CJ. Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex.
Arterioscler. Thromb. Vasc. Biol. 25: 1180-1185 (2005).
*
-
Huuskonen J, Vishnu M, Pullinger CR, Fielding PE, Fielding CJ. Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor.
Biochemistry 43: 1626-1632 (2004).
*
-
Hwang SS, Kim YU, Lee W, Lee GR. Differential expression of nuclear receptors in T helper cells.
J. Microbiol. Biotechnol. 19: 208-214 (2009).
*
-
Hwang ST, Urizar NL, Moore DD, Henning SJ. Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor.
Gastroenterology 122: 1483-1492 (2002).
*
-
Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Mol. Endocrinol. 17: 1255-1267 (2003).
*
-
Igarashi M, Yogiashi Y, Mihara M, Takada I, Kitagawa H, Kato S. Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene.
Mol. Cell. Biol. 27: 7947-7954 (2007).
*
-
Iguchi T, Watanabe H, Katsu Y. Toxicogenomics and ecotoxicogenomics for studying endocrine disruption and basic biology.
Gen. Comp. Endocrinol. 153: 25-29 (2007).
*
-
Ijpenberg A, Perez-Pomares JM, Guadix JA, Carmona R, Portillo-Sanchez V, Macias D, Hohenstein P, Miles CM, Hastie ND, Munoz-Chapuli R. Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis.
Dev. Biol. 312: 157-170 (2007).
*
-
IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B. In vivo activation of PPAR target genes by RXR homodimers.
EMBO J. 23: 2083-2091 (2004).
*
-
Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH. Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter.
Exp. Mol. Med. 37: 101-110 (2005).
*
-
Imai T. Functional genetic dissection of nuclear receptor signalling in obesity, diabetes and liver regeneration using spatiotemporally controlled somatic mutagenesis in the mouse.
Keio. J. Med. 52: 198-203 (2003).
*
-
Imai T, Jiang M, Chambon P, Metzger D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.
Proc. Natl. Acad. Sci. U.S.A. 98: 224-228 (2001).
*
-
Imai T, Jiang M, Kastner P, Chambon P, Metzger D. Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.
Proc. Natl. Acad. Sci. U.S.A. 98: 4581-4856 (2001).
*
-
Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M. Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.
Mol. Pharmacol. 71: 1298-1311 (2007).
*
-
Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P. Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
J. Invest. Dermatol. 127: 1250-1260 (2007).
*
-
Inoue I, Itoh F, Aoyagi S, Tazawa S, Kusama H, Akahane M, Mastunaga T, Hayashi K, Awata T, Komoda T, Katayama S. Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.
Biochem. Biophys. Res. Commun. 290: 131-139 (2002).
*
-
Ishaq M, Degray G, Natarajan V. Evidence for the involvement of tyrosine kinase ZAP 70 in nuclear retinoid receptor-dependent transactivation in T lymphocytes.
J. Biol. Chem. 280: 34152-34158 (2005).
*
-
Ishaq M, Fan M, Natarajan V. Accumulation of RXR alpha during activation of cycling human T lymphocytes: modulation of RXRE transactivation function by mitogen-activated protein kinase pathways.
J. Immunol. 165: 4217-4225 (2000).
*
-
Ishiguro H, Okubo Y, Ohtsuki T, Yamakawa-Kobayashi K, Arinami T. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence.
Am. J. Med. Genet. 114: 15-23 (2002).
*
-
Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
FEBS Lett. 580: 4929-4933 (2006).
*
-
Islam MR, Puri S, Rodova M, Magenheimer BS, Maser RL, Calvet JP. Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.
Am. J. Physiol. Renal Physiol. 295: F1845-F1854 (2008).
*
-
Issa LL, Leong GM, Barry JB, Sutherland RL, Eisman JA. Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk.
Endocrinology 142: 1606-1615 (2001).
*
-
Issemann I, Prince RA, Tugwood JD, Green S. The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs.
J. Mol. Endocrinol. 11: 37-47 (1993).
-
Ito M, Fukuzawa K, Ishikawa T, Mochizuki Y, Nakano T, Tanaka S. Ab initio fragment molecular orbital study of molecular interactions in liganded retinoid X receptor: specification of residues associated with ligand inducible information transmission.
J. Phys. Chem. B. 112: 12081-12094 (2008).
-
Ito M, Fukuzawa K, Mochizuki Y, Nakano T, Tanaka S. Ab initio fragment molecular orbital study of molecular interactions between liganded retinoid X receptor and its coactivator: roles of helix 12 in the coactivator binding mechanism.
J. Phys. Chem. B. 111: 3525-3533 (2007).
-
Ito M, Fukuzawa K, Mochizuki Y, Nakano T, Tanaka S. Ab initio fragment molecular orbital study of molecular interactions between liganded retinoid X receptor and its coactivator; part II: influence of mutations in transcriptional activation function 2 activating domain core on the molecular interactions.
J. Phys. Chem. A. 112: 1986-1998 (2008).
*
-
Itoh K, Hiromori Y, Kato N, Yoshida I, Itoh N, Ike M, Nagase H, Tanaka K, Nakanishi T. Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids.
Gen. Comp. Endocrinol. 163: 285-291 (2009).
-
Itoh M, Nakajima M, Higashi E, Yoshida R, Nagata K, Yamazoe Y, Yokoi T. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
J. Pharmacol. Exp. Ther. 319: 693-702 (2006).
*
-
Iwahori T, Matsuura T, Maehashi H, Sugo K, Saito M, Hosokawa M, Chiba K, Masaki T, Aizaki H, Ohkawa K, Suzuki T. CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.
Hepatology 37: 665-673 (2003).
*
-
Iwano S, Shibahara N, Saito T, Kamataki T. Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons.
FEBS Lett. 580: 890-893 (2006).
*
-
Iwata M, Eshima Y, Kagechika H. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.
Int. Immunol. 15: 1017-1025 (2003).
*
-
Jaaskelainen T, Itkonen A, Maenpaa PH. Retinoid-X-receptor-alpha-independent binding of vitamin D receptor to its response element from human osteocalcin gene.
Eur. J. Biochem. 228: 222-228 (1995).
-
Jaaskelainen T, Ryhanen S, Maenpaa PH. 9-cis Retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells.
J. Cell. Biochem. 89: 1164-1176 (2003).
*
-
Jacobs CM, Paulsen RE. Crosstalk between ERK2 and RXR regulates nuclear import of transcription factor NGFI-B.
Biochem. Biophys. Res. Commun. 336: 646-652 (2005).
*
-
Jagiello P, Gencik M, Arning L, Wieczorek S, Kunstmann E, Csernok E, Gross WL, Epplen JT. New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes.
Hum. Genet. 114: 468-477 (2004).
*
-
Jahnel J, Fickert P, Langner C, Hogenauer C, Silbert D, Gumhold J, Fuchsbichler A, Trauner M. Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice.
Liver Int. 29: 1316-1325 (2009).
*
-
Jakel H, Nowak M, Moitrot E, Dehondt H, Hum D, Penacchio LA, Fruchart-Najib J, Fruchart JC. The LXR ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c.
J. Biol. Chem. 279: 45462-45469 (2004).
*
-
James SY, Lin F, Kolluri SK, Dawson MI, Zhang XK. Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.
Cancer Res. 63: 3531-3538 (2003).
*
-
Janosek J, Hilscherova K, Blaha L, Holoubek I. Environmental xenobiotics and nuclear receptors - interactions, effects and in vitro assessment.
Toxicol. In Vitro 20: 18-37 (2006).
-
Jeninga EH, Bugge A, Nielsen R, Kersten S, Hamers N, Dani C, Wabitsch M, Berger R, Stunnenberg HG, Mandrup S, Kalkhoven E. Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).
J. Biol. Chem. 284: 26385-26393 (2009).
*
-
Jeninga EH, Gurnell M, Kalkhoven E. Functional implications of genetic variation in human PPARgamma.
Trends Endocrinol. Metab. 20: 380-387 (2009).
*
-
Jeninga EH, van Beekum O, van Dijk AD, Hamers N, Hendriks-Stegeman BI, Bonvin AM, Berger R, Kalkhoven E. Impaired PPARgamma function through mutation of a conserved salt bridge (R425C) in familial partial lipodystrophy.
Mol. Endocrinol. 21: 1049-1065 (2007).
*
-
Jeyakumar M, Katzenellenbogen JA. A dual-acceptor time-resolved Foster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: mimicking the cellular context of thyroid hormone…
Anal. Biochem. 386: 73-78 (2009).
*
-
Jeyakumar M, Webb P, Baxter JD, Scanlan TS, Katzenellenbogen JA. Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.
Biochemistry 47: 7465-7476 (2008).
*
-
Jiang W, Deng W, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert JM, Lobo-Ruppert SM. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.
Cancer Biol. Ther. 8: 289-298 (2009).
*
-
Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR. Regulation of ABCA1 expression in human keratinocytes and murine epidermis.
J. Lipid Res. 47: 2248-2258 (2006).
*
-
Jiang YJ, Lu B, Kim P, Paragh G, Schmitz G, Elias PM, Feingold KR. PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
J. Invest. Dermatol. 128: 104-109 (2008).
*
-
Jin CH, Pike JW. Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor.
Mol. Endocrinol. 10: 196-205 (1996).
*
-
Johnson EF, Hsu MH, Savas U, Griffin KJ. Regulation of P450 4A expression by peroxisome proliferator activated receptors.
Toxicology 181-182: 203-206 (2002).
*
-
Johnson EF, Palmer CN, Griffin KJ, Hsu MH. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation.
FASEB J. 10: 1241-1248 (1996).
*
-
Jokic N, Ling YY, Ward RE, Michael-Titus AT, Priestley JV, Malaspina A. Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis.
J. Neurochem. 103: 1821-1833 (2007).
-
Jones BB, Ohno CK, Allenby G, Boffa MB, Levin AA, Grippo JF, Petkovich M. New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid.
Mol. Cell. Biol. 15: 5226-5234 (1995).
*
-
Jones G, Jones D, Teal P, Sapa A, Wozniak M. The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand.
FEBS J. 273: 4983-4996 (2006).
*
-
Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D.
Physiol. Rev. 78: 1193-1231 (1998).
*
-
Jones KA, Fitzgibbon J, Woodward KJ, Goudie D, Ferguson-Smith MA, Povey S, Wolfe J, Solomon E. Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34.
Ann. Hum. Genet. 57: 195-201 (1993).
-
Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.
J. Biol. Chem. 277: 11019-11025 (2002).
*
-
Joshi S, Guleria R, Pan J, Dipette D, Singh US. Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.
Oncogene 25: 240-247 (2006).
*
-
Juge-Aubry CE, Gorla-Bajszczak A, Pernin A, Lemberger T, Wahli W, Burger AG, Meier CA. Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat.
J. Biol. Chem. 270: 18117-18122 (1995).
*
-
Jump DB. Dietary polyunsaturated fatty acid regulation of hepatic gene transcription.
Scand. J. Nutr. 46: 59-67 (2002). *
-
Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O. Fatty acid regulation of hepatic gene transcription.
J. Nutr. 135: 2503-2506 (2005).
*
-
Jump DB, Clarke SD, Thelen A, Liimatta M, Ren B, Badin MV. Dietary fat, genes, and human health.
Adv. Exp. Med. Biol. 422: 167-176 (1997).
-
Jung D, Hagenbuch B, Fried M, Meier PJ, Kullak-Ublick GA. Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse and rat NTCP gene.
Am. J. Physiol. Gastrointest. Liver Physiol. 286: G752-G761 (2004).
*
-
Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
Gastroenterology 122: 1954-1966 (2002).
*
-
Jung HY, Park SH, Yoo YD, Kim JS, Kim YH. CDK2/4 regulate retinoic acid-induced G1 arrest in hepatocellular carcinoma cells.
Hepatol. Res. 31: 143-152 (2005).
-
Juntunen K, Rochel N, Moras D, Vihko P. Large-scale expression and purification of the human vitamin D receptor and its ligand-binding domain for structural studies.
Biochem. J. 344: 297-303 (1999).
*
-
Jurutka PW, Bartik L, Whitfield GK, Mathern DR, Barthel TK, Gurevich M, Hsieh JC, Kaczmarska M, Haussler CA, Haussler MR. Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands.
J. Bone Miner. Res. 22 Suppl. 2: V2-V10 (2007).
*
-
Jurutka PW, Remus LS, Whitfield GK, Galligan MA, Haussler CA, Haussler MR. Biochemical evidence for a 170-kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts.
Biochem. Biophys. Res. Commun. 267: 813-819 (2000).
*
-
Jurutka PW, Thompson PD, Whitfield GK, Eichhorst KR, Hall N, Dominguez CE, Hsieh JC, Haussler CA, Haussler MR. Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.
J. Cell. Biochem. 94: 917-943 (2005).
*
-
Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R. Molecular mechanism of insulin resistance and obesity.
Exp. Biol. Med. (Maywood) 228: 1111-1117 (2003).
*
-
Kagechika H, Miyachi H. PPARs as molecular targets for drug discovery.
Nippon Rinsho 63: 549-555 (2005).
-
Kahlen JP, Carlberg C. Allosteric interaction of the 1alpha,25-dihydroxyvitamin D3 receptor and the retinoid X receptor on DNA.
Nucleic Acids Res. 25: 4307-4313 (1997).
*
-
Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori J, Kumagai M, Hashizume K. Functional interaction between Oct-1 and retinoid X receptor.
J. Biol. Chem. 274: 19103-19108 (1999).
*
-
Kakizawa T, Miyamoto T, Kaneko A, Yajima H, Ichikawa K, Hashizume K. Ligand-dependent heterodimerization of thyroid hormone receptor and retinoid X receptor.
J. Biol. Chem. 272: 23799-23804 (1997).
*
-
Kalsch AI, Peters A, Buhl B, Breedijk A, Prem K, Schmitt WH, Weiss C, Heeringa P, Kallenberg C, Birck R, Yard BA. Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in antineutrophil cytoplasmic antibody associated vasculitis patients.
Autoimmunity 42: 467-474 (2009).
-
Kalsotra A, Du L, Wang Y, Ladd PA, Kikuta Y, Duvic M, Boyd AS, Keeney DS, Strobel HW. Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways.
FASEB J. 22: 538-547 (2008).
*
-
Kamei Y, Miura S, Suganami T, Akaike F, Kanai S, Sugita S, Katsumata A, Aburatani H, Unterman TG, Ezaki O, Ogawa Y. Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.
Endocrinology 149: 2293-2305 (2008).
*
-
Kameue C, Tsukahara T, Ushida K. Alteration of gene expression in the colon of colorectal cancer model rat by dietary sodium gluconate.
Biosci. Biotechnol. Biochem. 70: 606-614 (2006).
*
-
Kanamori T, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Kojima S, Moriwaki H. Synergistic growth inhibition by acyclic retinoid and vitamin K(2) in human hepatocellular carcinoma cells.
Cancer Sci. 98: 431-437 (2007).
*
-
Kanaya E, Jingami H. The region of CQQQKPQRRP of PGC-1alpha interacts with the DNA-binding complex of FXR/RXRalpha.
Biochem. Biophys. Res. Commun. 342: 734-743 (2006).
*
-
Kanaya E, Shiraki T, Jingami H. The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.
Biochem. J. 382: 913-921 (2004).
*
-
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa JI. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor (PPAR) gamma / retinoid X receptor (RXR) pathway.
Mol. Pharmacol. 67: 766-774 (2005).
*
-
Kane KF, Langman MJ, Williams GR. 1,25-Dihydroxyvitamin D3 and retinoid X receptor expression in human colorectal neoplasms.
Gut 36: 255-258 (1995).
*
-
Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H. Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.
Leuk. Res. 32: 884-892 (2008).
-
Kang KW, Lee SJ, Kim SG. Molecular mechanism of Nrf2 activation by oxidative stress.
Antioxid. Redox Signal. 7: 1664-1673 (2005).
-
Kang S. The mechanism of action of topical retinoids.
Cutis 75 (2 Suppl.): 10-13 (2005).
-
Kang S, Li XY, Duell EA, Voorhees JJ. The retinoid X receptor agonist 9-cis-retinoic acid and the 24-hydroxylase inhibitor ketoconazole increase activity of 1,25-dihydroxyvitamin D3 in human skin in vivo.
J. Invest. Dermatol. 108: 513-518 (1997).
*
-
Kanzleiter T, Schneider T, Walter I, Bolze F, Eickhorst C, Heldmaier G, Klaus S, Klingenspor M. Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis.
Physiol. Genomics 24: 37-44 (2005).
*
-
Karam SM, Hassan WM, John R. Expression of retinoid receptors in multiple cell lineages in the gastric mucosae of mice and humans.
J. Gastroenterol. Hepatol. 20: 1892-1899 (2005).
*
-
Karami S, Brennan P, Navratilova M, Mates D, Zaridze D, Janout V, Kollarova H, Bencko V, Matveev V, Szesznia-Dabrowska N, Holcatova I, Yeager M, Chanock S, Rothman N, Boffetta P, Chow WH, Moore LE. Vitamin D pathway genes, diet, and risk of renal cell carcinoma.
Int. J. Endocrinol. 2010: 879362 (2010).
*
-
Karami S, Brennan P, Rosenberg PS, Navratilova M, Mates D, Zaridze D, Janout V, Kollarova H, Bencko V, Matveev V, Szeszenia-Dabrowska N, Holcatova I, Yeager M, Chanock S, Menashe I, Rothman N, Chow WH, Boffetta P, Moore LE. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.
PLoS One 4: e7013 (2009).
*
-
Karlsson T, Vahlquist A, Torma H. Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways.
J. Dermatol. Sci. Jan 15 [Epub ahead of print] (2010).
-
Karpen SJ, Trauner M. The new therapeutic frontier - nuclear receptors and the liver.
J. Hepatol. Dec 24 [Epub ahead of print] (2009).
*
-
Karzenowski D, Potter DW, Padidam M. Inducible control of transgene expression with ecdysone receptor: gene switches with high sensitivity, robust expression, and reduced size.
Biotechniques 39: 191-192, 194, 196 (2005).
-
Kassam A, Hunter J, Rachubinski RA, Capone JP. Subtype- and response element-dependent differences in transactivation by peroxisome proliferator-activated receptors alpha and gamma.
Mol. Cell. Endocrinol. 141: 153-162 (1998).
-
Kassam A, Miao B, Young PR, Mukherjee R. Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding.
J. Biol. Chem. 278: 10028-10032 (2003).
*
-
Kassam A, Winrow CJ, Fernandez-Rachubinski F, Capone JP, Rachubinski RA. The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated …
J. Biol. Chem. 275: 4345-4350 (2000).
*
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
J. Biol. Chem. 277: 2908-2915 (2002).
*
-
Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.
Mol. Endocrinol. 15: 1720-1728 (2001).
*
-
Katagiri Y, Takeda K, Yu ZX, Ferrans VJ, Ozato K, Guroff G. Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B.
Nat. Cell Biol. 2: 435-440 (2000).
*
-
Kato S. Molecular mechanism of transcriptional control by nuclear vitamin receptors.
Br. J. Nutr. 84 Suppl. 2: S229-S233 (2000).
-
Katsuki H, Kurimoto E, Takemori S, Kurauchi Y, Hisatsune A, Isohama Y, Izumi Y, Kume T, Shudo K, Akaike A. Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling.
J. Neurochem. 110: 707-718 (2009).
-
Kawada T, Kamei Y, Fujita A, Hida Y, Takahashi N, Sugimoto E, Fushiki T. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors.
Biofactors 13: 103-109 (2000).
-
Kawata K, Kobayashi Y, Souda K, Kawamura K, Sumiyoshi S, Takahashi Y, Noritake H, Watanabe S, Suehiro T, Nakamura H. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis.
Antioxid. Redox Signal. Jan 8 [Epub ahead of print] (2010).
-
Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol. Int. 59: 152-160 (2009).
*
-
Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
Proc. Natl. Acad. Sci. U.S.A. 90: 2160-2164 (1993).
*
-
Keller H, Mahfoudi A, Dreyer C, Hihi AK, Medin J, Ozato K, Wahli W. Peroxisome proliferator-activated receptors and lipid metabolism.
Ann. N. Y. Acad. Sci. 684: 157-173 (1993).
*
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.
Cell. Metab. 10: 392-404 (2009).
-
Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein.
J. Biol. Chem. 276: 39438-39447 (2001).
*
-
Kersten S, Dawson MI, Lewis BA, Noy N. Individual subunits of heterodimers comprised of retinoic acid and retinoid X receptors interact with their ligands independently.
Biochemistry 35: 3816-3824 (1996).
*
-
Kersten S, Dong D, Lee W, Reczek PR, Noy N. Auto-silencing by the retinoid X receptor.
J. Mol. Biol. 284: 21-32 (1998).
*
-
Kersten S, Gronemeyer H, Noy N. The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state.
J. Biol. Chem. 272: 12771-12777 (1997).
*
-
Kersten S, Kelleher D, Chambon P, Gronemeyer H, Noy N. Retinoid X receptor alpha forms tetramers in solution.
Proc. Natl. Acad. Sci. U.S.A. 92: 8645-8649 (1995).
*
-
Kersten S, Pan L, Chambon P, Gronemeyer H, Noy N. Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor.
Biochemistry 34: 13717-13721 (1995).
-
Kersten S, Pan L, Noy N. On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor.
Biochemistry 34: 14263-14269 (1995).
-
Kersten S, Reczek PR, Noy N. The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor.
J. Biol. Chem. 272: 29759-29768 (1997).
*
-
Khalil H, Brunet A, Thibodeau J. A three-amino-acid-long HLA-DRbeta cytoplasmic tail is sufficient to overcome ER retention of invariant-chain p35.
J. Cell. Sci. 118: 4679-4687 (2005).
*
-
Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review).
J. Nutr. Biochem. 14: 554-667 (2003).
*
-
Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
J. Lipid Res. 45: 1169-1196 (2004).
*
-
Kikuchi H. Regulation of cytochrome P-450 (CYP) genes by nuclear receptors.
Nippon Eiseigaku Zasshi 56: 622-628 (2002).
-
Kikuchi R, Sobue S, Murakami M, Ito H, Kimura A, Iwasaki T, Shibayama S, Takagi A, Kojima T, Suzuki M, Banno Y, Nozawa Y, Murate T. Mechanism of vitamin D(3)-induced transcription of phospholipase D1 in HaCat human keratinocytes.
FEBS Lett. 581: 1800-1804 (2007).
*
-
Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J. Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.
J. Hepatol. 49: 787-798 (2008).
*
-
Kim HI, Koh YK, Kim TH, Kwon SK, Im SS, Choi HS, Kim KS, Ahn YH. Transcriptional activation of SHP by PPAR-gamma in liver.
Biochem. Biophys. Res. Commun. 360: 301-306 (2007).
*
-
Kim HT, Kong G, Denardo D, Li Y, Uray I, Pal S, Mohsin S, Hilsenbeck SG, Bissonnette R, Lamph WW, Johnson K, Brown PH. Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays.
Cancer Res. 66: 12009-12018 (2006).
*
-
Kim J, Min G, Kemper B. Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation …
J. Biol. Chem. 276: 7559-7567 (2001).
*
-
Kim MJ, Deplewski D, Ciletti N, Michel S, Reichert U, Rosenfield RL. Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Mol. Genet. Metab. 74: 362-369 (2001).
*
-
Kim MS, Fujiki R, Murayama A, Kitagawa H, Yamaoka K, Yamamoto Y, Mihara M, Takeyama KI, Kato S. 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter.
Mol. Endocrinol. 21: 334-342 (2007).
*
-
Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C. Repression of farnesoid X receptor during the acute phase response.
J. Biol. Chem. 278: 8988-8995 (2003).
*
-
Kim MS, Sweeney 1 TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, Feingold KR. Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
Metabolism 56: 267-279 (2007).
*
-
Kim S, Shevde NK, Pike JW. 1,25-Dihydroxyvitamin D(3) stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts.
J. Bone Miner. Res. 20: 305-317 (2005).
*
-
Kim S, Yamazaki M, Zella LA, Shevde NK, Pike JW. Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers.
Mol. Cell. Biol. 26: 6469-6486 (2006).
*
-
Kim SH, Nam GW, Lee HK, Moon SJ, Chang IS. The effects of Musk T on peroxisome proliferator-activated receptor [PPAR]-alpha activation, epidermal skin homeostasis and dermal hyaluronic acid synthesis.
Arch. Dermatol. Res. 298: 273-282 (2006).
*
-
Kim TH, Kim H, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH. Interrelationship between LXRalpha, SREBP-1c, PPARgamma and SHP in the transcriptional regulation of glucokinase gene expression in liver.
J. Biol. Chem. 284: 15071-15083 (2009).
*
-
Kimmel-Jehan C, Darwish HM, Strugnell SA, Jehan F, Wiefling B, DeLuca HF. DNA bending is induced by binding of vitamin D receptor-retinoid X receptor heterodimers to vitamin D response elements.
J. Cell. Biochem. 74: 220-228 (1999).
*
-
Kintscher U, Goetze S, Wakino S, Kim S, Nagpal S, Chandraratna RA, Graf K, Fleck E, Hsueh WA, Law RE. Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.
Eur. J. Pharmacol. 401: 259-270 (2000).
*
-
Kirchmeyer M, Deffaud J, Sebillaud S, Moulin D, Koufany M, Netter P, Bianchi A, Jouzeau JY. Evidence for species differences in the regulation of MMPs by all-trans retinoic acid in cytokine-stimulated chondrocytes.
Biorheology 45: 415-432 (2008).
-
Kirchmeyer M, Koufany M, Sebillaud S, Netter P, Jouzeau JY, Bianchi A. All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation.
Arthritis Res. Ther. 10: R141 (2008).
*
-
Kirchner S, Kieu T, Chow C, Casey S, Blumberg B. Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.
Mol. Endocrinol. Feb 16 [Epub ahead of print] (2010).
-
Kitareewan S, Burka LT, Tomer KB, Parker CE, Deterding LJ, Stevens RD, Forman BM, Mais DE, Heyman RA, McMorris T, Weinberger C. Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.
Mol. Biol. Cell 7: 1153-1166 (1996).
*
-
Kizaki M, Ikeda Y, Tanosaki R, Nakajima H, Morikawa M, Sakashita A, Koeffler HP. Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.
Blood 82: 3592-3599 (1993).
*
-
Kleemann R, Verschuren L, van Erk MJ, Nikolsky Y, Cnubben NH, Verheij ER, Smilde AK, Hendriks HF, Zadelaar S, Smith GJ, Kaznacheev V, Nikolskaya T, Melnikov A, Hurt-Camejo E, van der Greef J, van Ommen B, Kooistra T. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis.
Genome Biol. 8: R200 (2007).
*
-
Klemann C, Je Raveney B, Oki S, Yamamura T. Retinoid signals and Th17-mediated pathology.
Nihon Rinsho Meneki Gakkai Kaishi 32: 20-28 (2009).
*
-
Kliewer SA. The nuclear pregnane X receptor regulates xenobiotic detoxification.
J. Nutr. 133: 2444S-2447S (2003).
*
-
Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Proc. Natl. Acad. Sci. U.S.A. 89: 1448-1452 (1992).
*
-
Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
Nature 355: 446-449 (1992).
*
-
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
Nature 358: 771-774 (1992).
*
-
Kliewer SA, Xu HE, Lambert MH, Willson TM. Peroxisome proliferator-activated receptors: from genes to physiology.
Recent Prog. Horm. Res. 56: 239-263 (2001).
*
-
Klopper JP, Sharma V, Berenz A, Hays WR, Loi M, Pugazhenthi U, Said S, Haugen BR. Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression.
Mol. Cancer 8: 16 (2009).
*
-
Klopper JP, Sharma V, Bissonnette R, Haugen BR. Combination PPARgamma and RXR agonist treatment in melanoma cells: functional importance of S100A2.
PPAR Res. 2010: 729876 (2010).
*
-
Knapp P, Jarzabek K, Blachnio A, Zbroch T. The role of peroxisome proliferator-activated receptors (PPAR) in carcinogenesis.
Ginekol. Pol. 77: 643-651 (2006).
-
Knol AC, Quereux G, Brocard A, Ballanger F, Khammari A, Nguyen JM, Dreno B. Absence of modulation of CD4+CD25(high) regulatory T cells in CTCL patients treated with bexarotene.
Exp. Dermatol. Oct 21 [Epub ahead of print] (2009).
-
Knutson DC, Clagett-Dame M. atRA regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesion.
Arch. Biochem. Biophys. 477: 163-174 (2008).
*
-
Kocdor H, Kocdor M, Canda T, Gurel D, Cehreli R, Yilmaz O, Alakavuklar M, Guner G. Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis.
Clin.Transl. Oncol. 11: 243-249 (2009).
-
Kochhar DM, Jiang H, Penner JD, Heyman RA. Placental transfer and developmental effects of 9-cis retinoic acid in mice.
Teratology 51: 257-265 (1995).
-
Koda T, Imai H, Morita M. Antiestrogenic activity of vitamin A in in vivo uterotrophic assay.
Life Sci. 80: 945-949 (2007).
*
-
Kohlstedt K, Gershome C, Trouvain C, Hofmann WK, Fichtlscherer S, Fleming I. Angiotensin converting enzyme (ACE) inhibitors modulate CRBP1 and adiponectin expression in adipocytes via the ACE-dependent signaling cascade.
Mol. Pharmacol. 75: 685-692 (2009).
*
-
Koike K. Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
J. Gastroenterol. 44 Suppl. 19: 82-88 (2009).
*
-
Kojima S, Okuno M, Matsushima-Nishiwaki R, Friedman SL, Moriwaki H. Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).
Int. J. Oncol. 24: 797-805 (2004).
-
Kolsch H, Lutjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Friedrichs S, Maier W, Heun R. RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism.
J. Cell. Mol. Med. Jun 9 [Epub ahead of print] (2008).
*
-
Komuves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ, Moser AH, Lobaccaro JM, Williams ML, Mangelsdorf DJ, Feingold KR. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.
J. Invest. Dermatol. 118: 25-34 (2002).
*
-
Konopleva M, Elstner E, McQueen TJ, Tsao T, Sudarikov A, Hu W, Schober WD, Wang RY, Chism D, Kornblau SM, Younes A, Collins SJ, Koeffler HP, Andreeff M. Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.
Mol. Cancer Ther. 3: 1249-1262 (2004).
-
Koo JS, Jetten AM, Belloni P, Yoon JH, Kim YD, Nettesheim P. Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells.
Biochem. J. 338: 351-357 (1999).
*
-
Kopf E, Plassat JL, Vivat V, de The H, Chambon P, Rochette-Egly C. Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.
J. Biol. Chem. 275: 33280-33288 (2000).
*
-
Kopij M, Rapak A. The role of nuclear receptors in cell death.
Postepy. Hig. Med. Dosw. (Online) 62: 571-581 (2008).
-
Koren R. Vitamin D receptor defects: the story of hereditary resistance to vitamin D.
Pediatr. Endocrinol. Rev. 3 Suppl. 3: 470-475 (2006).
-
Kosters A, White DD, Sun H, Thevananther S, Karpen SJ. Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha.
J. Hepatol. 51: 898-908 (2009).
-
Koszewski NJ, Reinhardt TA, Horst RL. Differential effects of 20-epi vitamin D analogs on the vitamin D receptor homodimer.
J. Bone Miner. Res. 14: 509-517 (1999).
-
Koszewski NJ, Reinhardt TA, Horst RL. Vitamin D receptor interactions with the murine osteopontin response element.
J. Steroid Biochem. Mol. Biol. 59: 377-388 (1996).
-
Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied AB, Demeneix B, Clerget-Froidevaux MS. Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo.
Mol. Cell. Endocrinol. Nov 6 [Epub ahead of print] (2009).
-
Kourelis K, Vandoros G, Kourelis T, Goumas P, Sotiropoulou-Bonikou G. Retinoid X receptor overexpression desensitizes laryngeal epithelium to carcinogenic effects associated with epidermal growth factor receptor upregulation.
J. Otolaryngol. Head Neck Surg. 38: 233-239 (2009).
-
Kraft JC, Schuh T, Juchau M, Kimelman D. The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development.
Proc. Natl. Acad. Sci. U.S.A. 91: 3067-3071 (1994).
*
-
Kraichely DM, Collins JJ 3rd, DeLisle RK, MacDonald PN. The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction.
J. Biol. Chem. 274: 14352-14358 (1999).
*
-
Kraichely DM, MacDonald PN. Transcriptional activation through the vitamin D receptor in osteoblasts.
Front. Biosci. 3: d821-d833 (1998).
-
Kratzner R, Frohlich F, Lepler K, Schroder M, Roher K, Dickel C, Tzvetkov MV, Quentin T, Oetjen E, Knepel W. A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription.
Mol. Pharmacol. 73: 509-517 (2008).
*
-
Krezel W, Dupe V, Mark M, Dierich A, Kastner P, Chambon P. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Proc. Natl. Acad. Sci. U.S.A. 93: 9010-9014 (1996).
*
-
Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN. Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Proc. Natl. Acad. Sci. U.S.A. Jan 4 [Epub ahead of print] (2010).
*
-
Krskova-Tybitanclova K, Macejova D, Brtko J, Baculikova M, Krizanova O, Zorad S. Short term 13-cis-retinoic acid treatment at therapeutic doses elevates expression of leptin, GLUT4, PPARgamma and aP2 in rat adipose tissue.
J. Physiol. Pharmacol. 59: 731-743 (2008).
*
-
Krucken J, Delic D, Pauen H, Woytalla A, El-Khadragy M, Dkhil MA, Mossmann H, Wunderlich F. Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria.
Malar. J. 8: 54 (2009).
-
Kruger KA, Blum JW, Greger DL. Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A.
J. Dairy Sci. 88: 3971-3981 (2005).
*
-
Kubota H, Chiba H, Takakuwa Y, Osanai M, Tobioka H, Kohama G, Mori M, Sawada N. Retinoid X receptor alpha and retinoic acid receptor gamma mediate expression of genes encoding tight-junction proteins and barrier function in F9 cells during visceral endodermal differentiation.
Exp. Cell Res. 263: 163-172 (2001).
*
-
Kullak-Ublick GA. Regulation of hepatic and intestinal bile acid transport by FXR controlled signaling pathways.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 51-52 (2006). *
-
Kullak-Ublick GA. Regulation of bile salt transporter genes by nuclear receptors.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 43. June 18-19 (2004). *
-
Kuno H, Kurian SM, Hendy GN, White J, deLuca HF, Evans CO, Nanes MS. Inhibition of 1,25-dihydroxyvitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-alpha: structural determinants within the vitamin D response element.
Endocrinology 134: 2524-2531 (1994).
-
Kuperstein F, Yakubov E, Dinerman P, Gil S, Eylam R, Salem N Jr, Yavin E. Overexpression of dopamine receptor genes and their products in the postnatal rat brain following maternal n-3 fatty acid dietary deficiency.
J. Neurochem. 95: 1550-1562 (2005).
*
-
Kurlandsky SB, Xiao JH, Duell EA, Voorhees JJ, Fisher GJ. Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes.
J. Biol. Chem. 269: 32821-32827 (1994).
*
-
Kurokawa R, DiRenzo J, Boehm M, Sugarman J, Gloss B, Rosenfeld MG, Heyman RA, Glass CK. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding.
Nature 371: 528-351 (1994).
*
-
Kurose K, Saeki M, Tohkin M, Hasegawa R. Thyroid hormone receptor mediates human MDR1 gene expression: identification of the response region essential for gene expression.
Arch. Biochem. Biophys. 474: 82-90 (2008).
*
-
Kushida A, Tamura H. Retinoic acids induce neurosteroid biosynthesis in human glial GI-1 cells via the induction of steroidogenic genes.
J. Biochem. 146: 917-923 (2009).
*
-
Labrecque J, Dumas F, Lacroix A, Bhat PV. A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.
Biochem. J. 305: 681-684 (1995).
*
-
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proc. Natl. Acad. Sci. U.S.A. 100: 5419-5424 (2003).
*
-
Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Mol. Cell. Biol. 23: 2182-2191 (2003).
*
-
Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.
J. Biol. Chem. 275: 10638-10647 (2000).
*
-
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proc. Natl. Acad. Sci. U.S.A. 98: 507-512 (2001).
*
-
Laflamme L, Hamann G, Messier N, Maltais S, M-F Langlois. RXR acts as a coregulator in the regulation of genes of the hypothalamo-pituitary axis by thyroid hormone receptors.
J. Mol. Endocrinol. 29: 61-72 (2002).
*
-
Lagu B, Lebedev R, Pio B, Yang M, Pelton PD. Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.
Bioorg. Med. Chem. Lett. 17: 3491-3496 (2007).
*
-
Lagu B, Pio B, Lebedev R, Yang M, Pelton PD. RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.
Bioorg. Med. Chem. Lett. 17: 3497-3503 (2007).
*
-
Lalloyer F, Pedersen TA, Gross B, Lestavel S, Yous S, Vallez E, Gustafsson JA, Mandrup S, Fievet C, Staels B, Tailleux A. Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.
Arterioscler. Thromb. Vasc. Biol. 29: 1488-1495 (2009).
-
Lalloyerc F, Fievet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A. The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
Arterioscler. Thromb. Vasc. Biol. 26: 2731-2737 (2006).
-
Lamba JK, Lin YS, Schuetz EG, Thummel KE. Genetic contribution to variable human CYP3A-mediated metabolism.
Adv. Drug Deliv. Rev. 54: 1271-1294 (2002).
*
-
Lamkin TJ, Chin V, Varvayanis S, Smith JL, Sramkoski RM, Jacobberger JW, Yen A. Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels.
J. Cell. Biochem. 97: 1328-1338 (2006).
*
-
Lammi J, Perlmann T, Aarnisalo P. Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers.
Arch. Biochem. Biophys. 472: 105-114 (2008).
*
-
Lampen A, Meyer S, Arnhold T, Nau H. Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes.
J. Pharmacol. Exp. Ther. 295: 979-985 (2000).
*
-
Lampen A, Meyer S, Nau H. Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.
Biochim. Biophys. Acta 1521: 97-106 (2001).
*
-
Lamprecht P, Wieczorek S, Epplen JT, Ambrosch P, Kallenberg CG. Granuloma formation in ANCA-associated vasculitides.
APMIS Suppl. 127: 32-36 (2009).
-
Landis MS, Patel HV, Capone JP. Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes.
J. Biol. Chem. 277: 4713-4721 (2002).
*
-
Landrier JF, Grober J, Demydchuk J, Besnard P. FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene.
FEBS Lett. 553: 299-303 (2003).
*
-
Landrier JF, Thomas C, Grober J, Zaghini I, Petit V, Poirier H, Niot I, Besnard P. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors.
Biochim. Biophys. Acta 1735: 41-49 (2005).
*
-
Latruffe N, Cherkaoui Malki M, Nicolas-Frances V, Clemencet MC, Jannin B, Berlot JP. Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases.
Biochem. Pharmacol. 60: 1027-1032 (2000).
*
-
Latruffe N, Cherkaoui Malki M, Nicolas-Frances V, Jannin B, Clemencet MC, Hansmannel F, Passilly-Degrace P, Berlot JP. Peroxisome-proliferator-activated receptors as physiological sensors of fatty acid metabolism: molecular regulation in peroxisomes.
Biochem. Soc. Trans. 29: 305-309 (2001).
*
-
Lattuada D, Vigano' P, Mangioni S, Sassone J, DI Francesco S, Vignali M, DI Blasio AM. Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity.
Mol. Endocrinol. 21: 602-612 (2007).
*
-
le Maire A, Grimaldi M, Roecklin D, Dagnino S, Vivat-Hannah V, Balaguer P, Bourguet W. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
EMBO Rep. 10: 367-373 (2009).
*
-
Lee CH, Kim HD, Shin SM, Kim SG. A novel mechanism of PPARgamma regulation of TGFbeta1: implication in cancer biology.
PPAR Res. 2008: 762398 (2008).
*
-
Lee GY, Kim NH, Zhao ZS, Cha BS, Kim YS. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
Biochem. J. 378: 983-990 (2004).
*
-
Lee HK, Park UH, Kim EJ, Um SJ. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.
EMBO J. 26: 3545-3557 (2007).
*
-
Lee HY, Suh YA, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ, Kurie JM. Stress pathway activation induces phosphorylation of retinoid X receptor.
J. Biol. Chem. 275: 32193-32199 (2000).
*
-
Lee J, Choi HS. Reverse cholesterol transport in cultured gallbladder epithelial cells.
Korean J. Gastroenterol. 43: 145-152 (2004).
-
Lee J, Shirk A, Oram JF, Lee SP, Kuver R. Polarized cholesterol and phospholipid efflux in cultured gall-bladder epithelial cells: evidence for an ABCA1-mediated pathway.
Biochem. J. 364: 475-484 (2002).
*
-
Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
Carcinogenesis 28: 1653-1658 (2007).
*
-
Lee MO, Liu Y, Zhang XK. A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene.
Mol. Cell. Biol. 15: 4194-4207 (1995).
*
-
Lee MS, Kliewer SA, Provencal J, Wright PE, Evans RM. Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.
Science 260: 1117-1121 (1993).
*
-
Lee MS, Sem DS, Kliewer SA, Provencal J, Evans RM, Wright PE. NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.
Eur. J. Biochem. 224: 639-650 (1994).
*
-
Lee S, Privalsky ML. Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties.
Mol. Endocrinol. 19: 863-878 (2005).
*
-
Lee SJ, Yang EK, Kim SG. Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated S6K1 inhibition: role for Zf9 dephosphorylation.
Mol. Pharmacol. 70: 415-425 (2006).
*
-
Lee SK, Lee B, Lee JW. Mutations in retinoid X receptor that impair heterodimerization with specific nuclear hormone receptor.
J. Biol. Chem. 275: 33522-33526 (2000).
*
-
Lee SM, Lee JY, Choi JE, Lee SY, Park JY, Kim DS. Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features.
Cancer Genet. Cytogenet. 197: 39-45 (2010).
-
Lee SW, Cho YS, Na JM, Park UH, Kang M, Kim EJ, Um SJ. Additional sex comb-like 1 represses RAR-mediated transcription through associating with heterochromatin protein 1 and lysine-specific demethylase 1.
J. Biol. Chem. 285: 18-29 (2010).
*
-
Lee TS, Lin CY, Tsai JY, Wu YL, Su KH, Lu KY, Hsiao SH, Pan CC, Kou YR, Hsu YP, Ho LT. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages.
Life Sci. 84: 97-104 (2009).
*
-
Lee Y, Thompson JT, de Lera AR, Vanden Heuvel JP. Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7.
J. Nutr. Biochem. 20: 848-859.e1-e5 (2009).
*
-
Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M, Moore DD. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression.
Mol. Cell Biol. 20: 187-195 (2000).
*
-
Lefebvre P. Molecular basis for designing selective modulators of retinoic acid receptor transcriptional activities.
Curr. Drug Targets Immune Endocr. Metabol. Disord. 1: 153-164 (2001).
-
Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ Jr, Liu XS, Lazar MA. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Genes Dev. 22: 2941-2952 (2008).
*
-
Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mager I, Viola JR, Simonsson O, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir El Andaloussi, Langel U. Delivery of nucleic acids with a stearylated (RxR)(4) peptide using a non-covalent co-incubation strategy.
J. Control Release 141: 42-51 (2010).
-
Leibowitz MD, Ardecky RJ, Boehm MF, Broderick CL, Carfagna MA, Crombie DL, D'Arrigo J, Etgen GJ, Faul MM, Grese TA, Havel H, Hein NI, Heyman RA, Jolley D, Klausing K, Liu S, Mais DE, Mapes CM, Marschke KB, Michellys PY, Montrose-Rafizadeh C, et al. Biological characterization of a heterodimer selective RXR modulator: potential benefits for the treatment of type 2 diabetes.
Endocrinology 147: 1044-1053 (2006).
*
-
Leid M. Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.
J. Biol. Chem. 269: 14175-14181 (1994).
*
-
Lemaire G, Balaguer P, Michel S, Rahmani R. Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides.
Toxicol. Appl. Pharmacol. 202: 38-49 (2005).
*
-
Lemon BD, Freedman LP. Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
Mol. Cell Biol. 16: 1006-1016 (1996).
*
-
Lemotte PK, Keidel S, Apfel CM. Phytanic acid is a retinoid X receptor ligand.
Eur. J. Biochem. 236: 328-333 (1996).
*
-
Lengqvist J, Mata De Urquiza A, Bergman AC, Willson TM, Sjovall J, Perlmann T, Griffiths WJ. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.
Mol. Cell. Proteomics 3: 692-703 (2004).
*
-
Lengqvist J, Mata de Urquiza A, Perlmann T, Sjovall J, Griffiths WJ. Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha.
J. Mass Spectrom. 40: 1448-1461 (2005).
*
-
Lenhard JM. PPAR gamma/RXR as a molecular target for diabetes.
Receptors Channels 7: 249-258 (2001).
-
Levesque D, Rouillard C. Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation.
Trends Neurosci. 30: 22-30 (2007).
*
-
Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Rosenberger M, Lovey A, et al. 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.
Nature 355: 359-361 (1992).
*
-
Levy E, Spahis S, Sinnett D, Peretti N, Maupas-Schwalm F, Delvin E, Lambert M, Lavoie MA. Intestinal cholesterol transport proteins: an update and beyond.
Curr. Opin. Lipidol. 18: 310-318 (2007).
-
Li A, Zhu X, Brown B, Craft CM. Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cells.
Invest. Ophthalmol. Vis. Sci. 44: 996-1007 (2003).
*
-
Li CC, Lii CK, Liu KL, Yang JJ, Chen HW. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation.
Toxicol. Appl. Pharmacol. 225: 329-336 (2007).
*
-
Li CC, Lii CK, Liu KL, Yang JJ, Chen HW. n-6 and n-3 Polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes.
J. Nutr. Biochem. 17: 707-715 (2006).
*
-
Li D, Li T, Wang F, Tian H, Samuels HH. Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.
Mol. Cell. Biol. 22: 5782-5792 (2002).
*
-
Li D, Yamada T, Wang F, Vulin AI, Samuels HH. Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer.
J. Biol. Chem. 279: 7427-7437 (2004).
*
-
Li D, Zimmerman TL, Thevananther S, Lee HY, Kurie JM, Karpen SJ. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent.
J. Biol. Chem. 277: 31416-31422 (2002).
*
-
Li G, Yin W, Chamberlain R, Hewett-Emmett D, Roberts JN, Yang X, Lippman SM, Clifford JL. Identification and characterization of the human retinoid X receptor alpha gene promoter.
Gene 372: 118-127 (2006).
*
-
Li H, Zhan T, Li C, Liu M, Wang QK. Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration.
Biochem. Biophys. Res. Commun. 388: 383-388 (2009).
*
-
Li J, Ma M, Wang Z. A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression.
Toxicol. Lett. 176: 198-206 (2008).
-
Li M, Chiba H, Warot X, Messaddeq N, Gerard C, Chambon P, Metzger D. RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.
Development 128: 675-688 (2001).
*
-
Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
Proc. Natl. Acad. Sci. U.S.A. 103: 11736-11741 (2006).
*
-
Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P. Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.
Nature 407: 633-636 (2000).
*
-
Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, Chambon P. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.
Proc. Natl. Acad. Sci. U.S.A. 102: 14795-14800 (2005).
*
-
Li N, Klaassen CD. Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide.
Mol. Pharmacol. 66: 694-701 (2004).
*
-
Li R, Saito T, Tanaka R, Satohisa S, Adachi K, Horie M, Akashi Y, Kudo R. Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium.
Cancer Lett. 219: 33-40 (2005).
*
-
Li RW, Gasbarre LC. A temporal shift in regulatory networks and pathways in the bovine small intestine during Cooperia oncophora infection.
Int. J. Parasitol. 39: 813-824 (2009).
*
-
Li X, Hansen PA, Xi L, Chandraratna RA, Burant CF. Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor-gamma (PPARgamma) and retinoic acid X receptors (RXR).
J. Biol. Chem. 280: 38317-38327 (2005).
*
-
Li XY, Xiao JH, Feng X, Qin L, Voorhees JJ. Retinoid X receptor-specific ligands synergistically upregulate 1, 25-dihydroxyvitamin D3-dependent transcription in epidermal keratinocytes in vitro and in vivo.
J. Invest. Dermatol. 108: 506-512 (1997).
*
-
Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, Xia C, Lala DS. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.
Mol. Endocrinol. 16: 506-514 (2002).
*
-
Li Y, Zhang Y, Hill J, Kim HT, Shen Q, Bissonnette RP, Lamph WW, Brown PH. The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice.
Br. J. Cancer 98: 1380-1388 (2008).
*
-
Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SD, Jiang XC, Eacho PI, Cao G, Paul SM. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
J. Neurochem. 88: 623-634 (2004).
*
-
Liao H, Langmann T, Schmitz G, Zhu Y. Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 22: 127-132 (2002).
*
-
Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Nat. Rev. Cancer 7: 357-369 (2007).
*
-
Lichti-Kaiser K, Brobst D, Xu C, Staudinger JL. A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.
J. Pharmacol. Exp. Ther. 331: 65-76 (2009).
*
-
Lin JH, Kim EJ, Bansal A, Seykora J, Richardson SK, Cha XY, Zafar S, Nasta S, Wysocka M, Benoit B, Rook AH, Fakharzadeh SS. Clinical and in vitro resistance to bexarotene in adult T cell leukemia: loss of RXR-alpha receptor.
Blood 112: 2484-2488 (2008).
*
-
Lin XF, Zhao BX, Chen HZ, Ye XF, Yang CY, Zhou HY, Zhang MQ, Lin SC, Wu Q. RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells.
J. Cell Sci. 117: 5609-5621 (2004).
*
-
Lin YW, Lien LM, Yeh TS, Wu HM, Liu YL, Hsieh RH. 9-cis Retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription.
Biochem. Biophys. Res. Commun. 377: 351-354 (2008).
*
-
Linard C, Gremy O, Benderitter M. Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-ASA agonist.
J. Pharmacol. Exp. Ther. 324: 911-920 (2008).
*
-
Linville A, Radtke K, Waxman JS, Yelon D, Schilling TF. Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches.
Dev. Biol. 325: 60-70 (2009).
*
-
Lippert WP, Burschka C, Gotz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R. Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.
ChemMedChem. 4: 1143-1152 (2009).
-
Lippman SM, Lotan R. Advances in the development of retinoids as chemopreventive agents.
J. Nutr. 130: 479S-482S (2000).
*
-
Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.
Anal. Chem. 79: 9398-9402 (2007).
*
-
Liu G, Moon TW, Metcalfe CD, Lee LE, Trudeau VL. A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.
Environ. Toxicol. Chem. 24: 2260-2266 (2005).
-
Liu H, Shaw CK, Reineke EL, Liu Y, Kao HY. RXRa helix 12 plays an inhibitory role in the recruitment of the p160 co-activators by unliganded RXRa/RARa heterodimers.
J. Biol. Chem. 279: 45208-45218 (2004).
*
-
Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W. The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors PXR and CAR.
Mol. Pharmacol. 76: 604-611 (2009).
*
-
Liu S, Ogilvie KM, Klausing K, Lawson MA, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat.
Endocrinology 143: 2880-2885 (2002).
*
-
Liu W, Hellman P, Li Q, Yu WR, Juhlin C, Nordlinder H, Rollman O, Akerstrom G, Torma H, Melhus H. Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.
Biochem. Biophys. Res. Commun. 229: 922-929 (1996).
*
-
Liu W, Nakamura H, Tsujimura T, Cheng J, Yamamoto T, Iwamoto Y, Imanishi H, Shimomura S, Yamamoto T, Hirasawa T, Inagaki S, Nishiguchi S, Hada T. Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor.
Cancer Sci. 97: 768-773 (2006).
*
-
Liu X, Lu L, Tao BB, Zhu YC. All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta1 and Ang II in rat mesangial cells.
Acta Pharmacol. Sin. 29: 1035-1041 (2008).
-
Liu XH, Tang CK. The research progress of ATP binding cassette transporter G1.
Sheng Li Ke Xue Jin Zhan 40: 229-233 (2009).
-
Liu Y, Kagechika H, Ishikawa J, Hirano H, Matsukuma S, Tanaka K, Nakamura S. Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.
J. Neurochem. 106: 1104-1116 (2008).
-
Liu YL, Sennitt MV, Hislop DC, Crombie DL, Heyman RA, Cawthorne MA. Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.
Int. J. Obes. Relat. Metab. Disord. 24: 997-1004 (2000).
-
Liu YY, Brent GA. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation.
Trends Endocrinol. Metab. Dec 14 [Epub ahead of print] (2009).
*
-
Liu YY, Nguyen C, Peleg S. Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor.
Mol. Endocrinol. 14: 1776-1787 (2000).
*
-
Lobaccaro JM, Repa JJ, Lu TT, Caira F, Henry-Berger J, Volle DH, Mangelsdorf DJ. Regulation of lipid metabolism by the orphan nuclear receptors.
Ann. Endocrinol. (Paris) 62: 239-247 (2001).
-
Lopez D, McLean MP. Activation of the rat scavenger receptor class B type I gene by PPARalpha.
Mol. Cell. Endocrinol. 251: 67-77 (2006).
-
Lorkowski S, Rust S, Engel T, Jung E, Tegelkamp K, Galinski EA, Assmann G, Cullen P. Genomic sequence and structure of the human ABCG1 (ABC8) gene.
Biochem. Biophys. Res. Commun. 280: 121-131 (2001).
*
-
Lotan R. Retinoids and chemoprevention of aerodigestive tract cancers.
Cancer Metastasis Rev. 16: 349-356 (1997).
-
Lotan R. Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.
Environ. Health Perspect. 105 Suppl. 4: 985-988 (1997).
-
Lou YR, Miettinen S, Kagechika H, Gronemeyer H, Tuohimaa P. Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Biochem. Biophys. Res. Commun. 338: 1973-1981 (2005).
*
-
Loudig O, Babichuk C, White J, Abu-Abed S, Mueller C, Petkovich M. Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism.
Mol. Endocrinol. 14: 1483-1497 (2000).
*
-
Loudig O, Maclean GA, Dore NL, Luu L, Petkovich M. Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility.
Biochem. J. 392: 241-248 (2005).
*
-
Love JD, Gooch JT, Benko S, Li C, Nagy L, Chatterjee VK, Evans RM, Schwabe JW. The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
J. Biol. Chem. 277: 11385-11391 (2002).
*
-
Lu B, Moser AH, Shigenaga JK, Feingold KR, Grunfeld C. Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.
J. Lipid Res. 47: 2179-2190 (2006).
*
-
Lu HC, Eichele G, Thaller C. Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis.
Development 124: 195-203 (1997).
*
-
Lu J, Chen M, Stanley SE, Li E. Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution.
Biochem. Biophys. Res. Commun. 365: 42-46 (2008).
*
-
Lu J, Cistola DP, Li E. Analysis of ligand binding and protein dynamics of human retinoid X receptor alpha ligand-binding domain by nuclear magnetic resonance.
Biochemistry 45: 1629-1639 (2006).
*
-
Lu J, Dawson MI, Hu QY, Xia Z, Dambacher JD, Ye M, Zhang XK, Li E. The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain.
Magn. Reson. Chem. 47: 1071-1080 (2009).
*
-
Lu Y, Heydel JM, Li X, Bratton S, Lindblom T, Radominska-Pandya A. Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element.
Drug Metab. Dispos. 33: 937-946 (2005).
*
-
Luke NS, Devito MJ, Shah I, El-Masri HA. Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction.
Bull. Math. Biol. Feb 12 [Epub ahead of print] (2010).
*
-
Luo P, Lin M, Lin M, Chen Y, Yang B, He Q. Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis.
Leuk. Lymphoma 50: 1183-1189 (2009).
-
Luo XM, Ross AC. Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.
Exp. Biol. Med. (Maywood) 231: 619-631 (2006).
*
-
Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT. Inhibition of Na/H(+) exchanger activity by parvovirus B19 protein NS1.
Cell. Physiol. Biochem. 23: 211-220 (2009).
-
Luria A, Furlow JD. Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos.
Proc. Natl. Acad. Sci. U.S.A. 101: 8987-8992 (2004).
*
-
Macchiarulo A, Rizzo G, Costantino G, Fiorucci S, Pellicciari R. Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP).
J. Mol. Graph Model. 24: 362-372 (2006).
*
-
Macdonald N, Holden PR, Roberts RA. Addition of peroxisome proliferator-activated receptor alpha to guinea pig hepatocytes confers increased responsiveness to peroxisome proliferators.
Cancer Res. 59: 4776-4780 (1999).
*
-
MacDonald PN, Baudino TA, Tokumaru H, Dowd DR, Zhang C. Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription.
Steroids 66: 171-176 (2001).
-
Macejova D, Dvorak Z, Vrzal R, Ulrichova J, Ondkova S, Brtko J. The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes.
Gen. Physiol. Biophys. 26: 240-242 (2007).
-
Macejova D, Krizanova O, Brtko J. Different mRNA expression profiling of nuclear retinoid, thyroid, estrogen and PPARgamma receptors, their coregulators and selected genes in rat liver and spleen in response to short-term in vivo administration of 13-cis retinoic acid.
Toxicol. Lett. 184: 114-120 (2009).
*
-
Macoritto M, Nguyen-Yamamoto L, Huang DC, Samuels S, Yang XF, Wang TT, White J, Kremer R. Phosphorylation of the human retinoid X receptor-alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands.
J. Biol. Chem. 283: 4943-4956 (2008).
*
-
Maden M. Retinoids have differing efficacies on alveolar regeneration in a dexamethasone treated mouse.
Am. J. Respir. Cell. Mol. Biol. 35: 260-267 (2006).
*
-
Maeda T, Kiguchi N, Fukazawa Y, Yamamoto A, Ozaki M, Kishioka S. Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.
Neuropsychopharmacology 32: 1133-1140 (2007).
-
Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors.
J. Lipid Res. 43: 2037-2041 (2002).
*
-
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
J. Biol. Chem. 277: 31900-31908 (2002).
*
-
Makita T, Hernandez-Hoyos G, Chen TH, Wu H, Rothenberg EV, Sucov HM. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4.
Genes Dev. 15: 889-901 (2001).
*
-
Malerod L, Sporstol M, Juvet LK, Mousavi SA, Gjoen T, Berg T, Roos N, Eskild W. Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1.
Biochem. Biophys. Res. Commun. 336: 1096-1105 (2005).
*
-
Malloy PJ, Peng L, Wang J, Feldman D. Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells.
Endocrinology 150: 1580-1587 (2009).
*
-
Malloy PJ, Wang J, Peng L, Nayak S, Sisk JM, Thompson CC, Feldman D. A unique insertion/duplication in the VDR gene that truncates the VDR causing hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
Arch. Biochem. Biophys. 460: 285-292 (2007).
*
-
Malloy PJ, Wang J, Srivastava T, Feldman D. Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor.
Mol. Genet. Metab. 99: 72-79 (2010).
*
-
Malloy PJ, Xu R, Peng L, Clark PA, Feldman D. A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
Mol. Endocrinol. 16: 2538-2546 (2002).
*
-
Malloy PJ, Xu R, Peng L, Peleg S, Al-Ashwal A, Feldman D. Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor function.
Endocrinology 145: 5106-5114 (2004).
*
-
Malloy PJ, Zhu W, Zhao XY, Pehling GB, Feldman D. A novel inborn error in the ligand-binding domain of the vitamin D receptor causes hereditary vitamin D-resistant rickets.
Mol. Genet. Metab. 73: 138-148 (2001).
*
-
Malo MS, Zhang W, Alkhoury F, Pushpakaran P, Abedrapo MA, Mozumder M, Fleming E, Siddique A, Henderson JW, Hodin RA. Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.
Mol. Endocrinol. 18: 1941-1962 (2004).
*
-
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
Genes Dev. 6: 329-344 (1992).
*
-
Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors.
Cell 83: 841-850 (1995).
*
-
Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Cell 66: 555-561 (1991).
*
-
Manninen T, Purmonen S, Ylikomi T. Interaction of nuclear receptors with hsp90 in living cells.
J. Steroid Biochem. Mol. Biol. 96: 13-18 (2005).
-
Mano H, Mori R, Ozawa T, Takeyama K, Yoshizawa Y, Kojima R, Arao Y, Masushige S, Kato S. Positive and negative regulation of retinoid X receptor gene expression by thyroid hormone in the rat. Transcriptional and post-transcriptional controls by thyroid hormone.
J. Biol. Chem. 269: 1591-1594 (1994).
*
-
Mao CT, Li TY, Qu P, Zhao Y, Wang R, Liu YX. Effects of early intervention on learning and memory in young rats of marginal vitamin A deficiency and it's mechanism.
Zhonghua Er Ke Za Zhi 44: 15-20 (2006).
-
Maraninchi M, Bourcigaux N, Dace A, El-Yazidi C, Malezet-Desmoulins C, Krempf M, Torresani J, Margotat A. A novel mutation (E333D) in the thyroid hormone beta receptor causing resistance to thyroid hormone syndrome.
Exp. Clin. Endocrinol. Diabetes 114: 569-576 (2006).
-
Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages.
J. Biol. Chem. 281: 32197-32206 (2006).
*
-
Marcus SL, Miyata KS, Rachubinski RA, Capone JP. Transactivation by PPAR/RXR heterodimers in yeast is potentiated by exogenous fatty acid via a pathway requiring intact peroxisomes.
Gene Expr. 4: 227-239 (1995).
-
Mark M, Ghyselinck NB, Chambon P. Function of retinoic acid receptors during embryonic development.
Nucl. Recept. Signal. 7:e002 (2009).
*
-
Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis.
Annu. Rev. Pharmacol. Toxicol. 46: 451-480 (2006).
*
-
Mark M, Ghyselinck NB, Wendling O, Dupe V, Mascrez B, Kastner P, Chambon P. A genetic dissection of the retinoid signalling pathway in the mouse.
Proc. Nutr. Soc. 58: 609-613 (1999).
*
-
Mark M, Kastner P, Ghyselinck NB, Krezel W, Dupe V, Chambon P. Genetic control of the development by retinoic acid.
C. R. Seances Soc. Biol. Fil. 191: 77-90 (1997).
-
Marrapodi M, Chiang JY. Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
J. Lipid Res. 41: 514-520 (2000).
*
-
Marschall HU, Wagner M, Zollner G, Fickert P, Gumhold J, Silbert D, Diczfalusy U, Benthin L, Grundstrom R, Gustafsson U, Sahlin S, Einarsson C, Trauner M. Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 47. June 18-19 (2004). *
-
Martens JH, Brinkman AB, Simmer F, Francoijs KJ, Nebbioso A, Ferrara F, Altucci L, Stunnenberg HG. PML-RARalpha/RXR alters the epigenetic landscape in acute promyelocytic leukemia.
Cancer Cell 17: 173-185 (2010).
-
Martin G, Poirier H, Hennuyer N, Crombie D, Fruchart JC, Heyman RA, Besnard P, Auwerx J. Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target.
J. Biol. Chem. 275: 12612-12618 (2000).
*
-
Martin PG, Lasserre F, Calleja C, Van Es A, Roulet A, Concordet D, Cantiello M, Barnouin R, Gauthier B, Pineau T. Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks.
Gene Expr. 12: 177-192 (2005).
-
Mascrez B, Ghyselinck NB, Chambon P, Mark M. A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.
Proc. Natl. Acad. Sci. U.S.A. 106: 4272-4277 (2009).
*
-
Mascrez B, Ghyselinck NB, Watanabe M, Annicotte JS, Chambon P, Auwerx J, Mark M. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.
EMBO Rep. 5: 285-290 (2004).
*
-
Mascrez B, Mark M, Krezel W, Dupe V, LeMeur M, Ghyselinck NB, Chambon P. Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.
Development 128: 2049-2062 (2001).
*
-
Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Bonkowski MS, Panici JA, Przybylski GK, Bartke A. Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice.
J. Gerontol. A. Biol. Sci. Med. Sci. 60: 1238-1245 (2005).
-
Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Bartke A. Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice.
J. Gerontol. A. Biol. Sci. Med. Sci. 60: 1394-1398 (2005).
-
Masuyama H, Suwaki N, Tateishi Y, Nakatsukasa H, Segawa T, Hiramatsu Y. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.
Mol. Endocrinol. 19: 1170-1180 (2005).
*
-
Matic M, Corradin AP, Tsoli M, Clarke SJ, Polly P, Robertson GR. The alternatively spliced murine pregnane X receptor isoform, mPXR(delta171-211) exhibits a repressive action.
Int. J. Biochem. Cell. Biol. Jan 7 [Epub ahead of print] (2010).
*
-
Matkovits T, Christakos S. Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation.
Mol. Endocrinol. 9: 232-242 (1995).
*
-
Matsui I, Hamano T, Tomida K, Inoue K, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Kawachi H, Rakugi H, Imai E, Isaka Y. Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.
Nephrol. Dial. Transplant. 24: 2354-2361 (2009).
-
Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXR dependent regulation of fatty acid synthase.
J. Lipid Res. 47: 2754-2761 (2006).
*
-
Matsumoto A, Mizukami H, Mizuno S, Umegaki K, Nishikawa JI, Shudo K, Kagechika H, Inoue M. beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages.
Biochem. Pharmacol. 74: 256-264 (2007).
*
-
Matsumoto S, Hashimoto K, Yamada M, Satoh T, Hirato J, Mori M. Liver X receptor-alpha positively regulates proopiomelanocortin (POMC) gene expression at the transcriptional level in the pituitary.
Mol. Endocrinol. 23: 47-60 (2009).
*
-
Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M. The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.
Toxicol. Sci. 109: 50-58 (2009).
*
-
Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Moriwaki H, Friedman SL, Kojima S. Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma.
Cancer Res. 61: 7675-7682 (2001).
*
-
Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H. Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.
Carcinogenesis 24: 1353-1359 (2003).
*
-
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Aberrant metabolism of retinoid X receptor proteins in human hepatocellular carcinoma.
Mol. Cell. Endocrinol. 121: 179-190 (1996).
-
Matsuzaka Y, Makino S, Nakajima K, Tomizawa M, Oka A, Kimura M, Bahram S, Tamiya G, Inoko H. New polymorphic microsatellite markers in the human MHC class II region.
Tissue Antigens 56: 492-500 (2000).
*
-
McCarthy TC, Li X, Sinal CJ. Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein-3 gene expression by bile acids.
J. Biol. Chem. 280: 23232-23242 (2005).
*
-
Medin JA, Minucci S, Driggers PH, Lee IJ, Ozato K. Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptor beta homodimer.
Mol. Cell. Endocrinol. 105: 27-35 (1994).
-
Medina-Diaz IM, Estrada-Muniz E, Reyes-Hernandez OD, Ramirez P, Vega L, Elizondo G. Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.
Toxicol. Appl. Pharmacol. 239: 162-168 (2009).
*
-
Meester-Smoor MA, Janssen MJ, Grosveld GC, de Klein A, van Ijcken WF, Douben H, Zwarthoff EC. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR induced gene expression.
Carcinogenesis 29: 2025-2034 (2008).
*
-
Mello T, Polvani S, Galli A. Peroxisome proliferator-activated receptor and retinoic X receptor in alcoholic liver disease.
PPAR Res. 2009: 748174 (2009).
*
-
Mengeling BJ, Lee S, Privalsky ML. Coactivator recruitment is enhanced by thyroid hormone receptor trimers.
Mol. Cell. Endocrinol. 280: 47-62 (2008).
-
Mertz JR, Shang E, Piantedosi R, Wei S, Wolgemuth DJ, Blaner WS. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation.
J. Biol. Chem. 272: 11744-11749 (1997).
*
-
Metzger D, Chambon P. Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.
Handb. Exp. Pharmacol. 178: 511-524 (2007).
-
Mey J, Schrage K, Wessels I, Vollpracht-Crijns I. Effects of inflammatory cytokines IL-1beta, IL-6, and TNFalpha on the intracellular localization of retinoid receptors in Schwann cells.
Glia 55: 152-164 (2007).
-
Meyer MB, Goetsch PD, Pike JW. Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone.
J. Steroid Biochem. Mol. Biol. Feb 17 [Epub ahead of print] (2010).
-
Meyer MB, Watanuki M, Kim S, Shevde NK, Pike JW. The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal calls.
Mol. Endocrinol. 20: 1447-1461 (2006).
*
-
Meyer MB, Zella LA, Nerenz RD, Pike JW. Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo.
J. Biol. Chem. 282: 22344-22352 (2007).
*
-
Mic FA, Molotkov A, Benbrook DM, Duester G. Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis.
Proc. Natl. Acad. Sci. U.S.A. 100: 7135-7140 (2003).
*
-
Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacol. Rev. 58: 726-741 (2006).
*
-
Miller A, Crumbley C, Prufer K. The N-terminal nuclear localization sequences of liver X receptors alpha and beta bind to importin alpha and are essential for both nuclear import and transactivating functions.
Int. J. Biochem. Cell. Biol. 41: 834-843 (2009).
*
-
Miller VA, Rigas JR, Benedetti FM, Verret AL, Tong WP, Kris MG, Gill GM, Loewen GR, Truglia JA, Ulm EH, Warrell RP Jr. Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.
Clin. Cancer Res. 2: 471-475 (1996).
*
-
Minucci S, Pelicci PG. Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force.
Cancer Cell 12: 1-3 (2007).
-
Mistry NF, Cresci S. PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure.
Heart Fail. Rev. Nov 8 [Epub ahead of print] (2008).
-
Miyata KS, McCaw SE, Meertens LM, Patel HV, Rachubinski RA, Capone JP. Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha.
Mol. Cell. Endocrinol. 146: 69-76 (1998).
-
Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP. The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling.
J. Biol. Chem. 271: 9189-9192 (1996).
*
-
Mochizuki K, Sakaguchi N, Takabe S, Goda T. De-phosphorylation of TRalpha-1 by p44/42 MAPK inhibition enhances T(3)-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells.
Biochem. Biophys. Res. Commun. 359: 979-984 (2007).
*
-
Mochizuki K, Suruga K, Fukami H, Kiso Y, Takase S, Goda T. Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells.
Life Sci. 80: 140-145 (2006).
*
-
Mochizuki K, Suruga K, Kitagawa M, Takase S, Goda T. Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine.
Arch. Biochem. Biophys. 389: 41-48 (2001).
*
-
Mochizuki K, Suruga K, Yagi E, Takase S, Goda T. The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine.
Biochim. Biophys. Acta 1531: 68-76 (2001).
*
-
Mohler DL, Shen G. The synthesis of tethered ligand dimers for PPARgamma-RXR protein heterodimers.
Org. Biomol. Chem. 4: 2082-2087 (2006).
*
-
Moise AR, Kuksa V, Blaner W, Baehr W, Palczewski K. Metabolism and transactivation activity of 13,14-dihydroretinoic acid.
J. Biol. Chem. 280: 27815-27825 (2005).
*
-
Molin S, Ruzicka T. Alitretinoin: a new treatment option for chronic refractory hand eczema.
Hautarzt. 59: 703-709 (2008).
*
-
Moll UM, Marchenko N, Zhang XK. p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction.
Oncogene 25: 4725-4743 (2006).
*
-
Monden T, Hosoya T, Nakajima Y, Kishi M, Satoh T, Hashimoto K, Kasai K, Yamada M, Mori M. Herbal medicine, Hachimi-jio-gan, and its component Cinnamomi cortex activate the peroxisome proliferator-activated receptor alpha in renal cells.
Endocr. J. 55: 529-533 (2008).
*
-
Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M. p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
Mol. Endocrinol. 13: 1695-1703 (1999).
*
-
Moniaux N, Junker WM, Singh AP, Jones AM, Batra SK. Characterization of human mucin MUC17: complete coding sequence and organization.
J. Biol. Chem. 281: 23676-23685 (2006).
*
-
Montanaro MA, Gonzalez MS, Bernasconi AM, Brenner RR. Role of liver X receptor, insulin and peroxisome proliferator activated receptor alpha on in vivo desaturase modulation of unsaturated fatty acid biosynthesis.
Lipids 42: 197-210 (2007).
-
Montesinos MM, Pellizas CG, Velez ML, Susperreguy S, Masini-Repiso AM, Coleoni AH. Thyroid hormone receptor beta(1) gene expression is increased by dexamethasone at transcriptional level in rat liver.
Life Sci. 78: 2584-2594 (2006).
*
-
Montessuit C, Papageorgiou I, Lerch R. Nuclear receptors agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.
Endocrinology 149: 1064-1074 (2008).
*
-
Montrone M, Martorelli D, Rosato A, Dolcetti R. Retinoids as critical modulators of immune functions: new therapeutic perspectives for old compounds.
Endocr. Metab. Immune Disord. Drug Targets 9: 113-131 (2009).
-
Moore JT, Kliewer SA. Use of the nuclear receptor PXR to predict drug interactions.
Toxicology 153: 1-10 (2000).
*
-
Moraes LA, Piqueras L, Bishop-Bailey D. Peroxisome proliferator-activated receptors and inflammation.
Pharmacol. Ther. 110: 371-385 (2006).
*
-
Moraes LA, Swales KE, Wray JA, Damazo A, Gibbins JM, Warner TD, Bishop-Bailey D. Non-genomic signalling of the retinoid X receptor through binding and inhibiting Gq in human platelets.
Blood 109: 3741-3744 (2007).
*
-
Moras D. Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?
Cell Metab. 9: 8-10 (2009).
*
-
Moreau A, Maurel P, Vilarem MJ, Pascussi JM. Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.
Biochem. Biophys. Res. Commun. 360: 76-82 (2007).
*
-
Mori M, Metzger D, Picaud S, Hindelang C, Simonutti M, Sahel J, Chambon P, Mark M. Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.
Am. J. Pathol. 164: 701-710 (2004).
*
-
Moriishi K, Mochizuki R, Moriya K, Miyamoto H, Mori Y, Abe T, Murata S, Tanaka K, Miyamura T, Suzuki T, Koike K, Matsuura Y. Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis.
Proc. Natl. Acad. Sci. U.S.A. 104: 1661-1666 (2007).
*
-
Morishita KI, Yakushiji N, Ohsawa F, Takamatsu K, Matsuura N, Makishima M, Kawahata M, Yamaguchi K, Tai A, Sasaki K, Kakuta H. Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.
Bioorg. Med. Chem. Lett. 19: 1001-1003 (2009).
-
Morita K, Kawana K, Sodeyama M, Shimomura I, Kagechika H, Makishima M. Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1.
Biochem. Pharmacol. 71: 98-107 (2006).
*
-
Moriwaki H, Shimizu M, Okuno M, Nishiwaki-Matsushima R. Chemoprevention of liver carcinogenesis with retinoids: basic and clinical aspects.
Hepatol. Res. 37 Suppl. 2: S299-S302 (2007).
*
-
Morrison LJ, McLellan S, Sweeney L, Chan C, Macleod A, Tait A, Turner CM. Differential host responses to Trypanosoma brucei infection: a role for parasite genetic diversity.
Infect. Immun. Jan 19 [Epub ahead of print] (2010).
*
-
Motojima K. Peroxisome proliferator-activated receptor (PPAR)-dependent and -independent transcriptional modulation of several non-peroxisomal genes by peroxisome proliferators.
Biochimie 79: 101-106 (1997).
-
Motojima K. PPAR-mediated diverse responses in various tissues of mouse.
Cell. Biochem. Biophys. 32: 205-211 (2000).
-
Motojima K, Peters JM, Gonzalez FJ. PPAR alpha mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse.
Biochem. Biophys. Res. Commun. 230: 155-158 (1997).
*
-
Motomura K, Ohata M, Satre M, Tsukamoto H. Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.
Am. J. Physiol. Endocrinol. Metab. 281: E420-E429 (2001).
*
-
Motomura K, Sakai H, Isobe H, Nawata H. Effects of retinoids on the production of tumour necrosis factor-alpha and nitric oxide by lipopolysaccharide-stimulated rat Kupffer cells in vitro: evidence for participation of retinoid X receptor signalling pathway.
Cell. Biochem. Funct. 15: 95-101 (1997).
*
-
Mottino AD, Catania VA. Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents.
World J. Gastroenterol. 14: 7068-7074 (2008).
*
-
Mou L, Lankford-Turner P, Leander MV, Bissonnette RP, Donahoe RM, Royal W. RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.
J. Neuroimmunol. 147: 99-105 (2004).
-
Moyes KM, Drackley JK, Morin DE, Bionaz M, Rodriguez-Zas SL, Everts RE, Lewin HA, Loor JJ. Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPAR-gamma signaling as potential mechanism for the negative relationships between immune response ..
BMC Genomics 10: 542 (2009).
*
-
Mozaffarian D. Trans fatty acids - effects on systemic inflammation and endothelial function.
Atheroscler. Suppl. 7: 29-32 (2006).
-
Muangmoonchai R, Smirlis D, Wong SC, Edwards M, Phillips IR, Shephard EA. Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1.
Biochem. J. 355: 71-78 (2001).
*
-
Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with Wnt/beta-catenin/Tcf signalling: Wnt you like to know?
Endocr. Rev. 26: 898-915 (2005).
*
-
Munetsuna E, Hojo Y, Hattori M, Ishii H, Kawato S, Ishida A, Kominami SA, Yamazaki T. Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures.
Endocrinology 150: 4260-4269 (2009).
*
-
Murad H, Collet P, Brunner E, Schohn H, Becuwe P, Devignes MD, Dauca M, Domenjoud L. Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes.
Biochimie 89: 329-336 (2007).
-
Murad H, Collet P, Huin-Schohn C, Al-Makdissy N, Kerjan G, Chedotal A, Donner M, Devignes MD, Becuwe P, Schohn H, Domenjoud L, Dauca M. Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Int. J. Oncol. 28: 977-984 (2006).
*
-
Murai J, Ikegami D, Okamoto M, Yoshikawa H, Tsumaki N. Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2.
J. Biol. Chem. 283: 27677-27687 (2008).
*
-
Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, Ichihara M, Takagi A, Kojima T, Tanaka K, Koizumi-T K, Kyogashima M, Suzuki M, Banno Y, Nozawa Y, Murate T. ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI.
J. Neurochem. Nov 7 [Epub ahead of print] (2009).
-
Murakami T, Walczak R, Caron S, Duhem C, Vidal V, Darteil R, Staels B. The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes.
Biochem. J. 407: 461-469 (2007).
*
-
Murthy S, Born E, Mathur SN, Field FJ. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
J. Lipid Res. 43: 1054-1064 (2002).
*
-
Myers KA, Lambe KG, Aldridge TC, Macdonald N, Tugwood JD. Amino acid residues in both the DNA-binding and ligand-binding domains influence transcriptional activity of the human peroxisome proliferator-activated receptor alpha.
Biochem. Biophys. Res. Commun. 239: 522-526 (1997).
*
-
Na SY, Choi HS, Kim JW, Na DS, Lee JW. Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor.
J. Biol. Chem. 273: 30933-30938 (1999).
*
-
Na SY, Kang BY, Chung SW, Han SJ, Ma X, Trinchieri G, Im SY, Lee JW, Kim TS. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB.
J. Biol. Chem. 274: 7674-7680 (1999).
*
-
Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO, Chung M, Moore DD, Lee JW. IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells.
J. Biol. Chem. 273: 3212-3215 (1998).
*
-
Nachimuthu S, Raggi P. Novel agents to manage dyslipidemias and impact atherosclerosis.
Cardiovasc. Hematol. Disord. Drug Targets 6: 209-217 (2006).
-
Nagao A, Olson JA. Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of beta-carotene.
FASEB J. 8: 968-973 (1994).
*
-
Nagao K, Yanagita T. Bioactive lipids in metabolic syndrome.
Prog. Lipid Res. 47: 127-146 (2008).
*
-
Nagao Y, French BA, Cai Y, French SW, Wan YJ. Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.
J. Cell. Biochem. 69: 189-200 (1998).
*
-
Nagasawa M, Hara T, Kashino A, Akasaka Y, Ide T, Murakami K. Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene.
Biochem. Pharmacol. 78: 523-530 (2009).
*
-
Nagata T, Kanno Y, Ozato K, Taketo M. The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters.
Gene 142: 183-189 (1994).
-
Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M. Physical mapping of the retinoid X receptor B gene in mouse and human.
Immunogenetics 41: 83-90 (1995).
-
Nagpal S, Chandraratna RA. Recent developments in receptor-selective retinoids.
Curr. Pharm. Des. 6: 919-931 (2000).
-
Nagy L, Saydak M, Shipley N, Lu S, Basilion JP, Yan ZH, Syka P, Chandraratna RA, Stein JP, Heyman RA, Davies PJ. Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter.
J. Biol. Chem. 271: 4355-4365 (1996).
*
-
Nahoum V, Perez E, Germain P, Rodriguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Proc. Natl. Acad. Sci. U.S.A. 104: 17323-17328 (2007).
*
-
Nakamura K, Inoue I, Takahashi S, Komoda T, Katayama S. Cryptochrome and period proteins are regulated by the CLOCK/BMAL1 gene: crosstalk between the PPARs/RXRalpha-regulated and CLOCK/BMAL1-regulated systems.
PPAR Res. 2008: 348610 (2008).
*
-
Nakanishi T. Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor.
J. Toxicol. Sci. 33: 269-276 (2008).
*
-
Nakatani T, Katsumata A, Miura S, Kamei Y, Ezaki O. Effects of fish oil feeding and fasting on LXRalpha/RXRalpha binding to LXRE in the SREBP-1c promoter in mouse liver.
Biochim. Biophys. Acta 1736: 77-86 (2005).
*
-
Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D. A novel function of differentiation revealed by cDNA microarray profiling of p75-regulated gene expression.
Differentiation 73: 385-396 (2005).
*
-
Napoli JL. Biochemical pathways of retinoid transport, metabolism, and signal transduction.
Clin. Immunol. Immunopathol. 80: S52-S62 (1996).
-
Narayanan NK, Narayanan BA, Reddy BS. A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors.
Int. J. Oncol. 26: 785-792 (2005).
-
Nasrollahzadeh J, Siassi F, Doosti M, Eshraghian MR, Shokri F, Modarressi MH, Mohammadi-Asl J, Abdi K, Nikmanesh A, Karimian SM. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression.
Lipids Health Dis. 7: 45 (2008).
*
-
Nau H. Chemical structure - teratogenicity relationships, toxicokinetics and metabolism in risk assessment of retinoids.
Toxicol. Lett. 82-83: 975-979 (1995).
-
Nawata H, Yanase T, Okabe T, Nomura M. Steroid receptor superfamily and its mechanism of action.
Nippon Rinsho 66: 9-15 (2008).
-
Necela BM, Su W, Thompson EA. Peroxisome proliferator activated receptor gamma downregulates follistatin in intestinal epithelial cells through Sp1.
J. Biol. Chem. 283: 29784-29794 (2008).
*
-
Neimark E, Chen F, Li X, Shneider BL. Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.
Hepatology 40: 149-156 (2004).
*
-
Neugebauer P, Goldbergova-Pavkova M, Kala P, Bocek O, Jerabek P, Poloczek M, Vytiska M, Parenica J, Mikulik R, Jarkovsky J, Semrad B, Spinar J, Vasku A. Nuclear receptors gene polymorphisms and risk of restenosis and clinical events following coronary stenting.
Vnitr. Lek. 55: 1135-1140 (2009).
-
Neumeier M, Weigert J, Schaffler A, Weiss T, Kirchner S, Laberer S, Scholmerich J, Buechler C. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.
Biochem. Biophys. Res. Commun. 334: 924-929 (2005).
*
-
Nezbedova P, Brtko J. 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action.
Endocr. Regul. 38: 29-38 (2004).
*
-
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V. Molecular and metabolic retinoid pathways in the human ocular surface.
Mol. Vis. 13: 1641-1650 (2007).
*
-
Ng KW, Zhou H, Manji S, Martin TJ. Regulation and regulatory role of the retinoids.
Crit. Rev. Eukaryot. Gene Expr. 5: 219-253 (1995).
-
Nguyen M, d'Alesio A, Pascussi JM, Kumar R, Griffin MD, Dong X, Guillozo H, Rizk-Rabin M, Sinding C, Bougneres P, Jehan F, Garabedian M. Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3.
J. Bone Miner. Res. 21: 886-894 (2006).
*
-
Nicodeme E, Nicaud M, Issandou M. Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.
Arterioscler. Thromb. Vasc. Biol. 15: 1660-1667 (1995).
-
Nielsen R, Grontved L, Stunnenberg HG, Mandrup S. Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery.
Mol. Cell. Biol. 26: 5698-5714 (2006).
*
-
Nielsen R, Pedersen TA, Hagenbeek D, Moulos P, Siersbaek R, Megens E, Denissov S, Borgesen M, Francoijs KJ, Mandrup S, Stunnenberg HG. Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.
Genes Dev. 22: 2953-2967 (2008).
*
-
Nikawa T, Ikemoto M, Tokuoka K, Teshima S, Alpers DH, Masui Y, Kishi K, Rokutan K. Interleukin-1beta enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 280: G510-G517 (2001).
*
-
Nikawa T, Rokutan K, Nanba K, Tokuoka K, Teshima S, Engle MJ, Alpers DH, Kishi K. Vitamin A up-regulates expression of bone-type alkaline phosphatase in rat small intestinal crypt cell line and fetal rat small intestine.
J. Nutr. 128: 1869-1877 (1998).
*
-
Nikcevic G, Savic T, Kovacevic-Grujicic N, Stevanovic M. Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved.
J. Neurochem. 107: 1206-1215 (2008).
-
Nishikawa J, Kitaura M, Matsumoto M, Imagawa M, Nishihara T. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer.
Nucleic Acids Res. 22: 2902-2907 (1994).
*
-
Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira KI, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, Sawada JI. The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.
Biochem. Pharmacol. 76: 1006-1013 (2008).
*
-
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, Lecluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer.
Biochemistry 45: 8579-8589 (2006).
*
-
Nofer JR, Remaley AT, Feuerborn R, Wolinska I, Engel T, von Eckardstein A, Assmann G. Apolipoprotein A-I (APO A-I) activates CDC42 signaling through ABCA1 transporter.
J. Lipid Res. 47: 794-803 (2006).
*
-
Nohara A, Kawashiri MA, Claudel T, Mizuno M, Tsuchida M, Takata M, Katsuda S, Miwa K, Inazu A, Kuipers F, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Arterioscler. Thromb. Vasc. Biol. 27: 923-928 (2007).
-
Nohara A, Kobayashi J, Mabuchi H. Retinoid X receptor heterodimer variants and cardiovascular risk factors.
J. Atheroscler. Thromb. 16: 303-318 (2009).
*
-
Nomura Y, Nagaya T, Hayashi Y, Kambe F, Seo H. 9-cis-Retinoic acid decreases the level of its cognate receptor, retinoid X receptor, through acceleration of the turnover.
Biochem. Biophys. Res. Commun. 260: 729-733 (1999).
*
-
Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, Zhu S, Hedderley D, Barnett MP, Roy NC. The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases.
Br. J. Nutr. 101: 169-181 (2009).
*
-
Norata GD, Catapano AL. Lipid lowering activity of drugs affecting cholesterol absorption.
Nutr. Metab. Cardiovasc. Dis. 14: 42-51 (2004).
-
Norata GD, Ongari M, Uboldi P, Pellegatta F, Catapano AL. Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.
Int. J. Mol. Med. 16: 717-722 (2005).
-
Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF. Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.
Drug Metab. Dispos. 33: 993-1003 (2005).
*
-
Norman AW. Identification of a unique nuclear receptor for 9-cis retinoic acid.
Nutr. Rev. 50: 230-231 (1992).
-
Novak K, Birmingham K, Pulverer B. Research news. At last, a ligand for RXR.
Nat. Med. 7: 31 (2001).
*
-
Nowickyj SM, Chithalen JV, Cameron D, Tyshenko MG, Petkovich M, Wyatt GR, Jones G, Walker VK. Locust retinoid X receptors: 9-cis-retinoic acid in embryos from a primitive insect.
Proc. Natl. Acad. Sci. U.S.A. 105: 9540-9545 (2008).
*
-
Numasawa T, Koga H, Ueyama K, Maeda S, Sakou T, Harata S, Leppert M, Inoue I. Human retinoic X receptor beta: complete genomic sequence and mutation search for ossification of posterior longitudinal ligament of the spine.
J. Bone Miner. Res. 14: 500-508 (1999).
-
Nunez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH. Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor.
Mol. Cell. Endocrinol. 127: 27-40 (1997).
-
Oberkofler H, Schraml E, Krempler F, Patsch W. Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha.
Biochem. J. 381: 357-363 (2004).
*
-
Ocadiz-Delgado R, Castaneda-Saucedo E, Indra AK, Hernandez-Pando R, Gariglio P. Impaired cervical homeostasis upon selective ablation of RXRalpha in epithelial cells.
Genesis 46: 19-28 (2008).
-
Ogino M, Nagata K, Yamazoe Y. Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells.
Drug Metab. Pharmacokinet. 17: 42-46 (2002).
*
-
Oh SY, Lee MY, Kim JM, Yoon S, Shin S, Park YN, Ahn YH, Kim KS. Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues.
J. Biol. Chem. 280: 5909-5916 (2005).
*
-
Ohama T, Hirano K, Zhang Z, Aoki R, Tsujii K, Nakagawa-Toyama Y, Tsukamoto K, Ikegami C, Matsuyama A, Ishigami M, Sakai N, Hiraoka H, Ueda K, Yamashita S, Matsuzawa Y. Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.
Biochem. Biophys. Res. Commun. 296: 625-630 (2002).
*
-
Ohashi E, Kogai T, Kagechika H, Brent GA. Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.
Cancer Res. 69: 3443-3450 (2009).
*
-
Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis.
Am. J. Physiol. 272: G589-G969 (1997).
*
-
Ohata M, Suzuki H, Sakamoto K, Hashimoto K, Nakajima H, Yamauchi M, Hokkyo K, Yamada H, Toda G. Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-alpha.
Alcohol Clin. Exp. Res. 28: 139S-144S (2004).
-
Ohata M, Yamauchi M, Takeda K, Toda G, Kamimura S, Motomura K, Xiong S, Tsukamoto H. RAR and RXR expression by Kupffer cells.
Exp. Mol. Pathol. 68: 13-20 (2000).
*
-
Ohnesorg T, Keller B, de Angelis MH, Adamski J. Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.
J. Mol. Endocrinol. 37: 185-197 (2006).
*
-
Ohta K, Chiba Y, Ogawa T, Endo Y. Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton.
Bioorg. Med. Chem. Lett. 18: 5050-5053 (2008).
*
-
Ohyama Y, Ozono K, Uchida M, Shinki T, Kato S, Suda T, Yamamoto O, Noshiro M, Kato Y. Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.
J. Biol. Chem. 269: 10545-10550 (1994).
*
-
Okamura M, Takano Y, Saito Y, Yao J, Kitamura M. Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor.
Nephrol. Dial. Transplant. 24: 3006-3012 (2009).
-
Okuno M, Kojima S, Matsushima-Nishiwaki R, Tsurumi H, Muto Y, Friedman SL, Moriwaki H. Retinoids in cancer chemoprevention.
Curr. Cancer Drug Targets 4: 285-298 (2004).
-
Okuwaki M, Takada T, Iwayanagi Y, Koh S, Kariya Y, Fujii H, Suzuki H. LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.
Pharm. Res. 24: 390-398 (2007).
*
-
Ollero M, Junaidi O, Zaman MM, Tzameli I, Ferrando AA, Andersson C, Blanco PG, Bialecki E, Freedman SD. Decreased expression of peroxisome proliferator activated receptor gamma in CFTR-/- mice.
J. Cell Physiol. 200: 235-244 (2004).
*
-
Omata Y, Folan M, Shaw M, Messer RL, Lockwood PE, Hobbs D, Bouillaguet S, Sano H, Lewis JB, Wataha JC. Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1).
Toxicol. In Vitro 20: 882-890 (2006).
-
Ondracek CR, Reese VC, Rushing CN, Oropeza CE, McLachlan A. Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines.
J. Virol. 83: 12545-12551 (2009).
-
Ondracek CR, Rushing CN, Reese VC, Oropeza CE, McLachlan A. Peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis.
J. Virol. 83: 12535-12544 (2009).
-
Ondrey F. Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: implications for chemoprevention.
Clin. Cancer Res. 15: 2-8 (2009).
*
-
Orfanos CE, Zouboulis CC, Almond-Roesler B, Geilen CC. Current use and future potential role of retinoids in dermatology.
Drugs 53: 358-388 (1997).
-
Ortiz MA, Piedrafita FJ, Pfahl M, Maki R. TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals.
Mol. Endocrinol. 9: 1679-1691 (1995).
*
-
Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N. Cellular retinoic acid bioavailability determines epithelial integrity: role of retinoic acid receptor alpha agonists in colitis.
Mol. Pharmacol. 71: 250-258 (2007).
*
-
Ostlund RE. Cholesterol absorption.
Curr. Opin. Gastroenterol. 18: 254-258 (2002).
-
Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Paabo S, Mous J, Kremoser C, Deuschle U. Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
Mol. Cell Biol. 23: 864-872 (2003).
*
-
Otto T, Fandrey J. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid X receptor alpha-dependent activation of hepatic leukemia factor.
Endocrinology 149: 2241-2250 (2008).
*
-
Ouamrane L, Larrieu G, Gauthier B, Pineau T. RXR activators molecular signalling: involvement of a PPAR alpha-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart.
Br. J. Pharmacol. 138: 845-854 (2003).
*
-
Ovsyannikova IG, Dhiman N, Haralambieva IH, Vierkant RA, O'Byrne MM, Jacobson RM, Poland GA. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.
Hum. Genet. Nov 10 [Epub ahead of print] (2009).
-
Paik J, Blaner WS, Swisshelm K. cis-Retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells.
Exp. Cell Res. 303: 183-196 (2005).
*
-
Paik J, Vogel S, Piantedosi R, Sykes A, Blaner WS, Swisshelm K. 9-cis-Retinoids: biosynthesis of 9-cis-retinoic acid.
Biochemistry 39: 8073-8084 (2000).
*
-
Palli SR, Kapitskaya MZ, Potter DW. The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor.
FEBS J. 272: 5979-5990 (2005).
*
-
Palmer CN, Hsu MH, Griffin HJ, Johnson EF. Novel sequence determinants in peroxisome proliferator signaling.
J. Biol. Chem. 270: 16114-16121 (1995).
*
-
Palmer CN, Hsu MH, Muerhoff AS, Griffin KJ, Johnson EF. Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.
J. Biol. Chem. 269: 18083-18089 (1994).
*
-
Pan DA, Mater MK, Thelen AP, Peters JM, Gonzalez FJ, Jump DB. Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.
J. Lipid Res. 41: 742-751 (2000).
*
-
Pan DH, Chen F, Neimark E, Li X, Shneider BL. FTF and LRH-1, two related but different transcription factors in human Caco-2 cells: their different roles in the regulation of bile acid transport.
Biochim. Biophys. Acta 1732: 31-37 (2005).
*
-
Pan L, Eckhoff C, Brinckerhoff CE. Suppression of collagenase gene expression by all-trans and 9-cis retinoic acid is ligand dependent and requires both RARs and RXRs.
J. Cell. Biochem. 57: 575-589 (1995).
-
Panguluri SK, Kumar P, Palli SR. Functional characterization of ecdysone receptor gene switches in mammalian cells.
FEBS J. 273: 5550-5563 (2006).
*
-
Papi A, Rocchi P, Ferreri AM, Guerra F, Orlandi M. Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.
Oncol. Rep. 21: 1083-1089 (2009).
-
Pare JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Belanger L. The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis, and regulated by a DR4 element.
J. Biol. Chem. 279: 21206-21216 (2004).
*
-
Parent R, Kolippakkam D, Booth G, Beretta L. Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth.
Cancer Res. 67: 4337-4345 (2007).
*
-
Park EY, Cho IJ, Kim SG. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.
Cancer Res. 64: 3701-3713 (2004).
*
-
Park JY, Kawada T, Han IS, Kim BS, Goto T, Takahashi N, Fushiki T, Kurata T, Yu R. Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
FEBS Lett. 572: 266-270 (2004).
*
-
Parrado A, Despouy G, Kraiba R, Le Pogam C, Dupas S, Choquette M, Robledo M, Larghero J, Bui H, Le Gall I, Rochette-Egly C, Chomienne C, Padua RA. Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms.
Nucleic Acids Res. 29: 4901-4908 (2001).
*
-
Pascussi JM, Drocourt L, Fabre JM, Maurel P, Vilarem MJ. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Mol. Pharmacol. 58: 361-372 (2000).
*
-
Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.
Biochim. Biophys. Acta 1619: 243-253 (2003).
*
-
Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.
Mol. Pharmacol. 58: 1441-1450 (2000).
*
-
Pascussi JM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, Vilarem MJ. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene.
Biochem. Biophys. Res. Commun. 260: 377-381 (1999).
*
-
Pascussi JM, Vilarem MJ. Molecular mechanisms linking xenobiotic metabolism and inflammation.
Med. Sci. (Paris) 24: 301-305 (2008).
-
Patel DD, Knight BL, Soutar AK, Gibbons GF, Wade DP. The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene.
Biochem. J. 351: 747-753 (2000).
*
-
Patel H, Truant R, Rachubinski RA, Capone JP. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.
J. Cell. Sci. 118: 175-186 (2005).
*
-
Pathrose P, Barmina O, Chang CY, McDonnell DP, Shevde NK, Pike JW. Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.
J. Bone Miner. Res. 17: 2196-2205 (2002).
-
Pavan B, Biondi C, Dalpiaz A. Nuclear retinoic acid receptor beta as a tool in chemoprevention trials.
Curr. Med. Chem. 13: 3553-3563 (2006).
-
Pavek P, Pospechova K, Svecova L, Syrova Z, Stejskalova L, Blazkova J, Dvorak Z, Blahos J. Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene.
Biochem. Pharmacol. 79: 277-287 (2010).
*
-
Pawlowska K, Sechman A, Suchanek I, Grzegorzewska A, Rzasa J. Effect of 9-cis retinoic acid (RA) on progesterone and estradiol secretion and RA receptor expression in the chicken ovarian follicles.
Folia Biol. (Krakow) 56: 65-72 (2008).
-
Peet DJ, Doyle DF, Corey DR, Mangelsdorf DJ. Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
Chem. Biol. 5: 13-21 (1998).
-
Pegorier JP. PPAR receptors and insulin sensitivity: new agonists in development.
Ann. Endocrinol. (Paris) 66: 10-17 (2005).
-
Peleg S, Sastry M, Collins ED, Bishop JE, Norman AW. Distinct conformational changes induced by 20-epi analogues of 1 alpha,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor.
J. Biol. Chem. 270: 10551-10558 (1995).
*
-
Pelton PD, Patel M, Demarest KT. Nuclear receptors as potential targets for modulating reverse cholesterol transport.
Curr. Top. Med. Chem. 5: 265-282 (2005).
-
Pemrick SM, Lucas DA, Grippo JF. The retinoid receptors.
Leukemia 8 Suppl. 3: S1-S10 (1994).
-
Pemrick SM, Lucas DA, Grippo JF. The retinoid receptors.
Leukemia 8: 1797-1806 (1994).
-
Peng X, Maruo T, Cao Y, Punj V, Mehta R, Das Gupta TK, Christov K. A novel RARbeta isoform directed by a distinct promoter P3 and mediated by retinoic acid in breast cancer cells.
Cancer Res. 64: 8911-8918 (2004).
*
-
Peng X, Mehta R, Wang S, Chellappan S, Mehta RG. Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells.
Cancer Res. 66: 7361-7369 (2006).
*
-
Perakyla M, Malinen M, Herzig KH, Carlberg C. Gene regulatory potential of non-steroidal vitamin D receptor ligands.
Mol. Endocrinol. 19: 2060-2073 (2005).
*
-
Perez-Rodriguez S, Ortiz MA, Pereira R, Rodríguez-Barrios F, de Lera AR, Piedrafita FJ. Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.
Eur. J. Med. Chem. 44: 2434-2446 (2009).
-
Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.
Genes Dev. 9: 769-782 (1995).
*
-
Perlmann T, Wallen-Mackenzie A. Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells.
Cell Tissue Res. 318: 45-52 (2004).
*
-
Petersen B, Jemec GB. Alitretinoin - its use in intractable hand eczema and other potential indications.
Drug Des. Devel. Ther. 3: 51-57 (2009).
-
Petkovich M. Regulation of gene expression by vitamin A: the role of nuclear retinoic acid receptors.
Annu. Rev. Nutr. 12: 443-471 (1992).
*
-
Pettersson F, Hanna N, Lagodich M, Dupere-Richer D, Couture MC, Choi C, Miller WH Jr. Rexinoids modulate steroid and xenobiotic receptor activity by increasing its protein turnover in a calpain-dependent manner.
J. Biol. Chem. 283: 21945-21952 (2008).
*
-
Pfahl M. Signal transduction by retinoid receptors.
Skin Pharmacol. 6 Suppl. 1: 8-16 (1993).
-
Phartiyal P, Sale H, Jones EM, Robertson GA. ER retention and rescue by heteromeric assembly regulates hERG 1a/1b surface channel composition.
J. Biol. Chem. 283: 3702-3707 (2008).
*
-
Phelps C, Gburcik V, Suslova E, Dudek P, Forafonov F, Bot N, MacLean M, Fagan RJ, Picard D. Fungi and animals may share a common ancestor to nuclear receptors.
Proc. Natl. Acad. Sci. U.S.A. 103: 7077-7081 (2006).
*
-
Pinaire J, Smith JR, Cho WK, Crabb DW. Effects of vitamin A deficiency on rat liver alcohol dehydrogenase expression and alcohol elimination rate in rats.
Alcohol Clin. Exp. Res. 24: 1759-1764 (2000).
*
-
Pinaire JA, Reifel-Miller A. Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome.
PPAR Res. 2007: 94156 (2007).
*
-
Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Mol. Endocrinol. 17: 259-272 (2003).
*
-
Pineda Torra I, Freedman LP, Garabedian MJ. Identification of DRIP205 as a coactivator for the farnesoid X receptor.
J. Biol. Chem. 279: 36184-36191 (2004).
*
-
Pircher PC, Kitto JL, Petrowski ML, Tangirala RK, Bischoff ED, Schulman IG, Westin SK. Farnesoid X receptor regulates bile acid-amino acid conjugation.
J. Biol. Chem. 278: 27703-27711 (2003).
*
-
Piu F, Gauthier NK, Wang F. beta-Arrestin 2 modulates the activity of nuclear receptor RAR beta2 through activation of ERK2 kinase.
Oncogene 25: 218-229 (2006).
*
-
Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, Muller M. Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.
Hepatology 35: 589-596 (2002).
*
-
Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Perez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
J. Biol. Chem. 280: 1625-1633 (2005).
*
-
Poirier H, Braissant O, Niot I, Wahli W, Besnard P. 9-cis-Retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene.
FEBS Lett. 412: 480-484 (1997).
*
-
Posokhova EN, Khoshchenko OM, Chasovskikh MI, Pivovarova EN, Dushkin MI. Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors alpha and gamma and of retinoid X receptors.
Biochemistry (Mosc.) 73: 296-304 (2008).
-
Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, May K, Siegmund W, Dvorak Z, Nachtigal P, Semecky V, Pavek P. Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines.
Mol. Cell. Endocrinol. 299: 178-187 (2009).
-
Poulain S, Lacomme S, Battaglia-Hsu SF, du Manoir S, Brochin L, Vignaud JM, Martinet N. Signalling with retinoids in the human lung: validation of new tools for the expression study of retinoid receptors.
BMC Cancer 9: 423 (2009).
*
-
Prufer K, Barsony J. Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor.
Mol. Endocrinol. 16: 1738-1751 (2002).
*
-
Prufer K, Racz A, Lin GC, Barsony J. Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors.
J. Biol. Chem. 275: 41114-41123 (2000).
*
-
Putcha BD, Fernandez EJ. Direct interdomain interactions can mediate allosterism in the thyroid receptor.
J. Biol. Chem. 284: 22517-22524 (2009).
*
-
Qi C, Zhu Y, Reddy JK. Peroxisome proliferator-activated receptors, coactivators, and downstream targets.
Cell. Biochem. Biophys. 32: 187-204 (2000).
-
Qian L, Zolfaghari R, Ross AC. Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver.
J. Lipid Res. Feb 10 [Epub ahead of print] (2010).
*
-
Qin P, Borges-Marcucci LA, Evans MJ, Harnish DC. Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes.
Am. J. Physiol. Gastrointest. Liver Physiol. 289: G267-G273 (2005).
*
-
Qin S, Okawa Y, Atangan LI, Brown G, Chandraratna RA, Zhao Y. Integrities of A/B and C domains of RXR are required for rexinoid-induced caspase activations and apoptosis.
J. Steroid Biochem. Mol. Biol. 112: 25-31 (2008).
-
Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RARalpha critically depends on recruitment of RXRalpha.
Blood Nov 17 [Epub ahead of print] (2009).
*
-
Qu L, Tang X. Bexarotene: a promising anticancer agent.
Cancer Chemother. Pharmacol. Sep 24 [Epub ahead of print] (2009).
*
-
Qu W, Zhou Y, Shao C, Sun Y, Zhang Q, Chen C, Jia J. Helicobacter pylori proteins response to nitric oxide stress.
J. Microbiol. 47: 486-493 (2009).
-
Quack M, Carlberg C. Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements.
J. Mol. Biol. 296: 743-756 (2000).
*
-
Quack M, Carlberg C. The impact of functional vitamin D(3) receptor conformations on DNA-dependent vitamin D(3) signaling.
Mol. Pharmacol. 57: 375-384 (2000).
*
-
Quack M, Carlberg C. Selective recognition of vitamin D receptor conformations mediates promoter selectivity of vitamin D analogs.
Mol. Pharmacol. 55: 1077-1087 (1999).
*
-
Quinn CM, Jessup W, Wong J, Kritharides L, Brown AJ. Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPAR-gamma ligands.
Biochem. J. 385: 823-830 (2005).
*
-
Rabelo R, Reyes C, Schifman A, Silva JE. A complex retinoic acid response element in the uncoupling protein gene defines a novel role for retinoids in thermogenesis.
Endocrinology 137: 3488-3496 (1996).
*
-
Racine R, Grandcolas L, Blanchardon E, Gourmelon P, Veyssiere G, Souidi M. Hepatic cholesterol metabolism following a chronic ingestion of cesium-137 starting at fetal stage in rats.
J. Radiat. Res. (Tokyo) 51: 37-45 (2010).
*
-
Radenne A, Akpa M, Martel C, Sawadogo S, Mauvoisin D, Mounier C. Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and non-genomic actions.
Am. J. Physiol. Endocrinol. Metab. 295: E884-E894 (2008).
*
-
Radominska-Pandya A, Chen G. Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta.
Biochemistry 41: 4883-4890 (2002).
*
-
Rajsbaum R, Fici D, Boggs DA, Fraser PA, Flores-Villanueva PO, Awdeh ZL. Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes.
Hum. Immunol. 63: 771-778 (2002).
-
Rajsbaum R, Fici D, Fraser PA, Flores-Villanueva PO, Awdeh ZL. Polymorphism of the human retinoid X receptor beta and linkage disequilibrium with HLA-DPB1.
Tissue Antigens 58: 24-29 (2001).
*
-
Ramagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, Dyment DA, Deluca GC, Herrera BM, Chao MJ, Sadovnick AD, Ebers GC, Knight JC. Expression of the multiple sclerosis-associated MHC class II allele HLA-DRB1*1501 is regulated by vitamin D.
PLoS Genet. 5: e1000369 (2009).
*
-
Ramiere C, Scholtes C, Diaz O, Icard V, Perrin-Cocon L, Trabaud MA, Lotteau V, Andre P. Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha.
J. Virol. 82: 10832-10840 (2008).
*
-
Rasooly R, Schuster GU, Gregg JP, Xiao JH, Chandraratna RA, Stephensen CB. Retinoid X receptor agonists increase Bcl2a1 expression and decrease apoptosis of naive T lymphocytes.
J. Immunol. 175: 7916-7929 (2005).
*
-
Ratajewski M, Bartosz G, Pulaski L. Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor.
Biochem. Biophys. Res. Commun. 350: 1082-1087 (2006).
*
-
Raval-Pandya M, Freedman LP, Li H, Christakos S. Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation.
Mol. Endocrinol. 12: 1367-1379 (1998).
*
-
Ravaux L, Denoyelle C, Monne C, Limon I, Raymondjean M, Hadri KE. Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6.
Mol. Cell. Biol. 27: 8374-8387 (2007).
*
-
Ravnskjaer K, Borgesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S. Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates glucose-stimulated insulin secretion in pancreatic beta-cells.
Endocrinology 146: 3266-3276 (2005).
*
-
Ravnskjaer K, Frigerio F, Boergesen M, Nielsen T, Maechler P, Mandrup S. PPARdelta is a fatty acid sensor, which enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid induced dysfunction.
J. Lipid Res. Nov 30 [Epub ahead of print] (2009).
*
-
Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.
Thromb. Haemost. 99: 86-95 (2008).
-
Razny U, Wator L, Polus A, Wan YJ, Dyduch G, Tomaszewska R, Dembinska-Kiec A. Hepatocyte RXR alpha deletion in mice leads to inhibition of angiogenesis.
Genes Nutr. 4: 69-72 (2009).
*
-
Read WL, Baggstrom MQ, Fracasso PM, Govindan R. A phase I study of bexarotene and rosiglitazone in patients with refractory cancers.
Chemotherapy 54: 236-241 (2008).
-
Redfern CP. Enhancing enhancers: new complexities in the retinoid regulation of gene expression.
Biochem. J. 383: e1-e2 (2004).
*
-
Redinger RN. The coming of age of our understanding of the enterohepatic circulation of bile salts.
Am. J. Surg. 185: 168-172 (2003).
*
-
Redinger RN. The role of the enterohepatic circulation of bile salts and nuclear hormone receptors in the regulation of cholesterol homeostasis: bile salts as ligands for nuclear hormone receptors.
Can. J. Gastroenterol. 17: 265-271 (2003).
*
-
Redonnet A, Ferrand C, Bairras C, Higueret P, Noel-Suberville C, Cassand P, Atgie C. Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats.
Br. J. Nutr. 100: 722-730 (2008).
*
-
Redonnet A, Groubet R, Noel-Suberville C, Bonilla S, Martinez A, Higueret P. Exposure to an obesity-inducing diet early affects the pattern of expression of peroxisome proliferator, retinoic acid, and triiodothyronine nuclear receptors in the rat.
Metabolism 50: 1161-1167 (2001).
*
-
Rees WD, McNeil CJ, Maloney CA. The roles of PPARs in the fetal origins of metabolic health and disease.
PPAR Res. 2008: 459030 (2008).
*
-
Reese V, Ondracek C, Rushing C, Li L, Oropeza CE, McLachlan A. Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development.
Int. J. Biochem. Cell Biol. Nov 23 [Epub ahead of print] (2009).
*
-
Reichrath J, Mittmann M, Kamradt J, Muller SM. Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation.
Histochem. J. 29: 127-133 (1997).
-
Ren B, Thelen A, Jump DB. Peroxisome proliferator-activated receptor alpha inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated receptor alpha as the mediator of polyunsaturated fatty acid regulation of S14 gene transcription.
J. Biol. Chem. 271: 17167-17173 (1996).
*
-
Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.
J. Biol. Chem. 277: 18793-18800 (2002).
*
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes Dev. 14: 2819-2830 (2000).
*
-
Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Science 289: 1524-1529 (2000).
*
-
Reynolds WF, Kumar AP, Piedrafita FJ. The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
Biochem. Biophys. Res. Commun. 349: 846-854 (2006).
*
-
Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD. Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.
J. Biol. Chem. 276: 14987-14995 (2001).
*
-
Ribot J, Felipe F, Bonet ML, Palou A. Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue.
Mol. Cell. Biochem. 266: 25-30 (2004).
*
-
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD. Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Blood 114: 5499-5511 (2009).
*
-
Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.
J. Leukoc. Biol. 80: 850-861 (2006).
*
-
Rieck M, Wedeken L, Muller-Brusselbach S, Meissner W, Muller R. Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor beta.
FEBS J. 274: 5068-5076 (2007).
*
-
Rigas JR, Dragnev KH. Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene.
Oncologist 10: 22-33 (2005).
*
-
Rizzo G, Fiorucci S. PPARs and other nuclear receptors in inflammation.
Curr. Opin. Pharmacol. 6: 421-427 (2006).
-
Rizzo G, Renga B, Antonelli E, Passeri D, Pellicciari R, Fiorucci S. The methyl transferase PRMT1 functions as co-activator of farnesoid X feceptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes.
Mol. Pharmacol. 68: 551-558 (2005).
*
-
Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S. Role of FXR in regulating bile acid homeostasis and relevance for human diseases.
Curr. Drug Targets Immune Endocr. Metabol. Disord. 5: 289-303 (2005).
-
Robinson CE, Wu X, Nawaz Z, Onate SA, Gimble JM. A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter.
Endocrinology 140: 1586-1593 (1999).
*
-
Roder K, Zhang L, Schweizer M. SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2.
FEBS Lett. 581: 2715-2720 (2007).
*
-
Rodriguez-Perez A, Palos-Paz F, Kaptein E, Visser TJ, Dominguez-Gerpe L, Alvarez-Escudero J, Lado-Abeal J. Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock.
Clin. Endocrinol. (Oxf.) 68: 821-827 (2008).
*
-
Romand R, Dolle P, Hashino E. Retinoid signaling in inner ear development.
J. Neurobiol. 66: 687-704 (2006).
*
-
Romert A, Tuvendal P, Simon A, Dencker L, Eriksson U. The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid.
Proc. Natl. Acad. Sci. U.S.A. 95: 4404-4409 (1998).
*
-
Rosner M, Hanneder M, Siegel N, Valli A, Hengstschlager M. The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.
Mutat. Res. 658: 234-246 (2008).
-
Roth D, Lynes E, Riemer J, Hansen HG, Althaus N, Simmen T, Ellgaard L. A di-arginine motif contributes to the ER-localization of the type I transmembrane ER oxidoreductase TMX4.
Biochem. J. 425: 195-205 (2010).
*
-
Rowe A. Retinoid X receptors.
Int. J. Biochem. Cell Biol. 29: 275-278 (1997).
*
-
Roy B, Taneja R, Chambon P. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a RXR-specific ligand.
Mol. Cell. Biol. 15: 6481-6487 (1995).
*
-
Royal W 3rd, Gartner S, Gajewski CD. Retinol measurements and retinoid receptor gene expression in patients with multiple sclerosis.
Mult. Scler. 8: 452-458 (2002).
*
-
Royal W 3rd, Leander M, Chen YE, Major EO, Bissonnette RP. Nuclear receptor activation and interaction with morphine.
J. Neuroimmunol. 157: 61-65 (2004).
-
Rubic T, Lorenz RL. Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10.
Cardiovasc. Res. 69: 527-535 (2006).
*
-
Rudolph MC, Neville MC, Anderson SM. Lipid synthesis in lactation: diet and the fatty acid switch.
J. Mammary Gland Biol. Neoplasia 12: 269-281 (2007).
*
-
Ruhl R, Plum C, Elmazar MM, Nau H. Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization.
Toxicol. Sci. 63: 82-89 (2001).
*
-
Rui E, Moura PR, Goncalves KA, Rooney RJ, Kobarg J. Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro.
Virus Res. 115: 31-42 (2006).
*
-
Rushmore TH, Kong AN. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
Curr. Drug Metab. 3: 481-490 (2002).
-
Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kacew S, Kim HS. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate.
J. Toxicol. Environ. Health A. 71: 1542-1549 (2008).
-
Ryu JY, Whang J, Park H, Im JY, Kim J, Ahn MY, Lee J, Kim HS, Lee BM, Yoo SD, Kwack SJ, Oh JH, Park KL, Han SY, Kim SH. Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats.
J. Toxicol. Environ. Health A. 70: 1296-1303 (2007).
*
-
Saban MR, Nguyen NB, Hammond TG, Saban R. Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation.
Am. J. Pathol. 160: 2095-2110 (2002).
*
-
Saban MR, O'Donnell MA, Hurst RE, Wu XR, Simpson C, Dozmorov I, Davis CA, Saban R. Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha.
BMC Immunol. 9: 4 (2008).
*
-
Sabol SL, Brewer HB Jr, Santamarina-Fojo S. The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.
J. Lipid Res. 46: 2151-2167 (2005).
*
-
Saeki M, Kurose K, Tohkin M, Hasegawa R. Identification of the functional vitamin D response elements in the human MDR1 gene.
Biochem. Pharmacol. 76: 531-542 (2008).
*
-
Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, Clyne CD. Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen …
Cancer Res. 65: 11762-11770 (2005).
*
-
Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
Mol. Endocrinol. 23: 188-201 (2009).
*
-
Sakaki J, Kishida M, Konishi K, Gunji H, Toyao A, Matsumoto Y, Kanazawa T, Uchiyama H, Fukaya H, Mitani H, Arai Y, Kimura M. Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.
Bioorg. Med. Chem. Lett. 17: 4804-4807 (2007).
*
-
Sakaki J, Konishi K, Kishida M, Gunji H, Kanazawa T, Uchiyama H, Fukaya H, Mitani H, Kimura M. Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure.
Bioorg. Med. Chem. Lett. 17: 4808-4811 (2007).
*
-
Sakuma T, Bhadhprasit W, Hashita T, Nemoto N. Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression.
Drug Metab. Dispos. 36: 878-884 (2008).
*
-
Sakuta T, Kanayama T. Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARgamma-specific retinoid, but not by ER35794, an RXR-selective agonist.
Int. J. Dermatol. 45: 1288-1295 (2006).
*
-
Salazar J, Guardiola M, Ferre R, Coll B, Alonso-Villaverde C, Winklhofer-Roob BM, Rock E, Fernandez-Ballart JD, Civeira F, Pocovi M, Masana L, Ribalta J. Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol.
Clin. Chem. Lab. Med. 45: 615-620 (2007).
*
-
Salbert G, Fanjul A, Piedrafita FJ, Lu XP, Kim SJ, Tran P, Pfahl M. Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.
Mol. Endocrinol. 7: 1347-1356 (1993).
*
-
Samad TA, Krezel W, Chambon P, Borrelli E. Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
Proc. Natl. Acad. Sci. U.S.A. 94: 14349-14354 (1997).
*
-
Sanchez-Martinez R, Castillo AI, Steinmeyer A, Aranda A. The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.
EMBO Rep. 7: 1030-1034 (2006).
*
-
Sanchez-Martinez R, Zambrano A, Castillo AI, Aranda A. Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.
Mol. Cell. Biol. 28: 3817-3829 (2008).
*
-
Sanderson LM, de Groot PJ, Hooiveld GJ, Koppen A, Kalkhoven E, Muller M, Kersten S. Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.
PLoS ONE 3: e1681 (2008).
*
-
Santín EP, Germain P, Quillard F, Khanwalkar H, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W. Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
J. Med. Chem. 52: 3150-3158 (2009).
*
-
Sasaki H, Harada H, Handa Y, Morino H, Suzawa M, Shimpo E, Katsumata T, Masuhiro Y, Matsuda K, Ebihara K, et al. Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression.
Biochemistry 34: 370-377 (1995).
-
Satih S, Savinel H, Rabiau N, Fontana L, Bignon YJ, Bernard-Gallon DJ. Expression analyses of nuclear receptor genes in breast cancer cell lines exposed to soy phytoestrogens after BRCA2 knockdown by TaqMan low-density array (TLDA).
J. Mol. Signal. 4: 3 (2009).
*
-
Savkur RS, Wu Y, Bramlett KS, Wang M, Yao S, Perkins D, Totten M, Searfoss G 3rd, Ryan TP, Su EW, Burris TP. Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.
Mol. Genet. Metab. 80: 216-226 (2003).
*
-
Schachtrup C, Emmler T, Bleck B, Sandqvist A, Spener F. Functional analysis of peroxisome proliferator response element motifs in genes of fatty acid binding proteins.
Biochem. J. 382: 239-245 (2004).
*
-
Schaiff WT, Bildirici I, Cheong M, Chern PL, Nelson DM, Sadovsky Y. PPARgamma and RXR signaling regulate fatty acid uptake by primary human placental trophoblasts.
J. Clin. Endocrinol. Metab. 90: 4267-4275 (2005).
*
-
Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM, Baxter RC. Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.
Arch. Biochem. Biophys. 465: 359-369 (2007).
*
-
Schedlich LJ, Muthukaruppan A, O'Han MK, Baxter RC. Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.
Mol. Endocrinol. 21: 2378-2390 (2007).
*
-
Schiffrin EL. Peroxisome proliferator-activated receptors and cardiovascular remodeling.
Am. J. Physiol. Heart Circ. Physiol. 288: H1037-H1043 (2005).
*
-
Schiffrin EL, Amiri F, Benkirane K, Iglarz M, Diep QN. Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension.
Hypertension 42: 664-668 (2003).
*
-
Schimerlik MI, Peterson VJ, Hobbs PD, Dawson MI, Leid M. Kinetic and thermodynamic analysis of 9-cis-retinoic acid binding to retinoid X receptor alpha.
Biochemistry 38: 6732-6740 (1999).
*
-
Schloss JV. New targets for the treatment of vascular diseases and diabetes.
IDrugs 1: 752-753 (1998).
-
Schluter A, Barbera MJ, Iglesias R, Giralt M, Villarroya F. Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation.
Biochem. J. 362: 61-69 (2002).
*
-
Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Watkins PB. Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor.
Drug Metab. Dispos. 29: 1446-1453 (2001).
*
-
Schmitz G, Langmann T. Metabolic learning in the intestine: adaptation to nutrition and luminal factors.
Horm. Metab. Res. 38: 452-454 (2006).
-
Schmitz G, Langmann T. Transcriptional regulatory networks in lipid metabolism control ABCA1 expression.
Biochim. Biophys. Acta 1735: 1-19 (2005).
*
-
Schmuth M, Elias PM, Feingold KR. Beyond glucocorticoids, retinoids and vitamin D - the evolution of nuclear hormone type transcription factor targeting in the skin.
J. Dtsch. Dermatol. Ges. 1: 352-362 (2003).
-
Schmuth M, Watson RE, Deplewski D, Dubrac S, Zouboulis CC, Griffiths CE. Nuclear hormone receptors in human skin.
Horm. Metab. Res. 39: 96-105 (2007).
-
Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation.
Biochim. Biophys. Acta 1302: 93-109 (1996).
-
Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression.
J. Lipid Res. 37: 907-925 (1996).
*
-
Schrader M, Bendik I, Becker-Andre M, Carlberg C. Interaction between retinoic acid and vitamin D signaling pathways.
J. Biol. Chem. 268: 17830-17836 (1993).
*
-
Schrader M, Muller KM, Carlberg C. Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone.
J. Biol. Chem. 269: 5501-5504 (1994).
*
-
Schuchardt JP, Wahlstrom D, Ruegg J, Giese N, Stefan M, Hopf H, Pongratz I, Hakansson H, Eichele G, Pettersson K, Nau H. The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo.
FEBS J. 276: 3043-3059 (2009).
*
-
Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
J. Biol. Chem. 276: 39411-39418 (2001).
*
-
Schwimmer LJ, Rohatgi P, Azizi B, Seley KL, Doyle DF. Creation and discovery of ligand-receptor pairs for transcriptional control with small molecules.
Proc. Natl. Acad. Sci. U.S.A. 101: 14707-14712 (2004).
*
-
Scribner KB, Odom DP, McGrane MM. Nuclear receptor binding to the retinoic acid response elements of the phosphoenolpyruvate carboxykinase gene in vivo: effects of vitamin A deficiency.
J. Nutr. Biochem. 18: 206-214 (2007).
*
-
Seguin-Devaux C, Devaux Y, Latger-Cannard V, Grosjean S, Rochette-Egly C, Zannad F, Meistelman C, Mertes PM, Longrois D. Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARalpha agonist in vivo.
Am. J. Physiol. Endocrinol. Metab. 283: E525-E535 (2002).
*
-
Seguin-Devaux C, Hanriot D, Dailloux M, Latger-Cannard V, Zannad F, Mertes PM, Longrois D, Devaux Y. Retinoic acid amplifies the host immune response to LPS through increased T lymphocytes number and LPS binding protein expression.
Mol. Cell. Endocrinol. 245: 67-76 (2005).
-
Seleiro EA, Darling D, Brickell PM. The chicken retinoid-X-receptor-gamma gene gives rise to two distinct species of mRNA with different patterns of expression.
Biochem. J. 301: 283-288 (1994).
*
-
Selva DM, Hirsch-Reinshagen V, Burgess B, Zhou S, Chan J, McIsaac S, Hayden MR, Hammond GL, Vogl AW, Wellington CL. The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.
J. Lipid Res. 45: 1040-1050 (2004).
*
-
Selvaraj RK, Klasing KC. Lutein and eicosapentaenoic acid interact to modify iNOS mRNA levels through the PPARgamma/RXR pathway in chickens and HD11 cell lines.
J. Nutr. 136: 1610-1616 (2006).
*
-
Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Yueh MF, Bonzo JA, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier OK, Tukey RH. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.
Drug Metab. Dispos. 35: 419-427 (2007).
*
-
Seo YK, Chung YT, Kim S, Echchgadda I, Song CS, Chatterjee B. Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin.
Gene 386: 218-223 (2007).
*
-
Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS. FOR, a novel orphan nuclear receptor related to farnesoid X receptor.
J. Biol. Chem. 277: 17836-17844 (2002).
*
-
Seoane S, Perez-Fernandez R. The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
Mol. Endocrinol. 20: 735-748 (2006).
*
-
Seol W, Choi HS, Moore DD. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.
Mol. Endocrinol. 9: 72-85 (1995).
*
-
Seree E, Villard PH, Pascussi JM, Pineau T, Maurel P, Nguyen QB, Fallone F, Martin PM, Champion S, Lacarelle B, Savouret JF, Barra Y. Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Gastroenterology 127: 1436-1445 (2004).
*
-
Serra F, Bonet ML, Puigserver P, Oliver J, Palou A. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids.
Int. J. Obes. Relat. Metab. Disord. 23: 650-655 (1999).
-
Seuter S, Vaisanen S, Radmark O, Carlberg C, Steinhilber D. Functional characterization of vitamin D responding regions in the human 5-lipoxygenase gene.
Biochim. Biophys. Acta 1771: 864-872 (2007).
*
-
Shaffer PL, Gewirth DT. Vitamin D receptor-DNA interactions.
Vitam. Horm. 68: 257-273 (2004).
-
Shaffer PL, Gewirth DT. Structural analysis of RXR-VDR interactions on DR3 DNA.
J. Steroid Biochem. Mol. Biol. 89-90: 215-219 (2004).
-
Shaffer PL, McDonnell DP, Gewirth DT. Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.
Biochemistry 44: 2678-2685 (2005).
*
-
Shan P, Yuan A, Shen L, Shen L, Chai D, Pu J, He B. RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.
Biochem. Biophys. Res. Commun. 375: 628-633 (2008).
*
-
Shang Q, Pan L, Saumoy M, Chiang JY, Tint GS, Salen G, Xu G. The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a functional LXRalpha binding site in the rabbit CYP7A1 promoter.
J. Lipid Res. 47: 997-1004 (2006).
*
-
Shankaranarayanan P, Rossin A, Khanwalkar H, Alvarez S, Alvarez R, Jacobson A, Nebbioso A, de Lera AR, Altucci L, Gronemeyer H. Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.
Cancer Cell 16: 220-231 (2009).
*
-
Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR. Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.
Endocrinology 147: 1438-1451 (2006).
*
-
Shea C, Richer J, Tzertzinis G, Maina CV. An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation.
Mol. Biochem. Parasitol. Feb 16 [Epub ahead of print] (2010).
-
Shearer KD, Goodman TH, Ross AW, Reilly L, Morgan PJ, McCaffery PJ. Photoperiodic regulation of retinoic acid signalling in the hypothalamus.
J. Neurochem. Oct 26 [Epub ahead of print] (2009).
-
Shen H, Zhang Y, Ding H, Wang X, Chen L, Jiang H, Shen X. Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter.
Cell. Physiol. Biochem. 22: 1-14 (2008).
*
-
Shen LH, He B, Wang BY, Zeng JZ, Zhou L, Hu LH, Bu J, Wang L. Effect of retinoid X receptor activation on oxidized low-density lipoprotein induced cell differentiation of murine macrophage cell line into dendritic like cells.
Zhonghua Xin Xue Guan Bing Za Zhi 35: 833-837 (2007).
-
Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J, Fluhr JW, Man MQ, Elias PM, Feingold KR. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
J. Invest. Dermatol. 118: 94-101 (2002).
*
-
Shibata S, Furuta K, Maeda M, Suzuki M, Oh-Hashi K, Kiuchi K, Hirata Y. (Arylthio)cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARgamma-dependent pathway.
Brain Res. 1296: 196-202 (2009).
-
Shimada T, Ross AC, Muccio DD, Brouillette WJ, Shealy YF. Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids.
Arch. Biochem. Biophys. 344: 220-227 (1997).
*
-
Shimizu M, Moriwaki H. Synergistic effects of PPARgamma ligands and retinoids in cancer treatment.
PPAR Res. 2008: 181047 (2008).
*
-
Shimizu M, Takai K, Moriwaki H. Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention.
Cancer Sci. 100: 369-374 (2009).
*
-
Shin DJ, Odom DP, Scribner KB, Ghoshal S, McGrane MM. Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver.
Mol. Cell. Endocrinol. 195: 39-54 (2002).
-
Shinozaki Y, Sato Y, Koizumi S, Ohno Y, Nagao T, Inoue K. Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase.
Neuroscience 147: 153-163 (2007).
-
Shiota G, Tsuchiya H, Hoshikawa Y. The liver as a target organ of retinoids.
Hepatol. Res. 36: 248-254 (2006).
-
Shiraki T, Sakai N, Kanaya E, Jingami H. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.
J. Biol. Chem. 278: 11344-11350 (2003).
*
-
Shneider BL. Regulation of intestinal bile acid transport in health and disease.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 44 (2006). *
-
Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB. HIV-1 Vpr suppresses transcriptional activity of PPARgamma and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy.
Mol. Endocrinol. 22: 234-247 (2008).
*
-
Shulman AI, Larson C, Mangelsdorf DJ, Ranganathan R. Structural determinants of allosteric ligand activation in RXR heterodimers.
Cell 116: 417-429 (2004).
*
-
Shulman AI, Mangelsdorf DJ. Retinoid X receptor heterodimers in the metabolic syndrome.
N. Engl. J. Med. 353: 604-615 (2005).
*
-
Sicinska W, Rotkiewicz P. Structural changes of vitamin D receptor induced by 20-epi-1alpha,25-(OH)(2)D(3): an insight from a computational analysis.
J. Steroid Biochem. Mol. Biol. 113: 253-258 (2009).
-
Singh RR, Gururaj AE, Vadlamudi RK, Kumar R. 9-cis-Retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.
J. Biol. Chem. 281: 15394-15404 (2006).
*
-
Sinha J, Chen F, Miloh T, Burns RC, Yu Z, Shneider BL. beta-Klotho and FGF 15/19 inhibit the apical sodium dependent bile acid transporter in enterocytes and cholangiocytes.
Am. J. Physiol. Gastrointest. Liver Physiol. 295: G996-G1003 (2008).
*
-
Smit JV, de Jong EM, van Hooijdonk CA, Otero ME, Boezeman JB, van de Kerkhof PC. Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation, and improves differentiation in lesional skin.
J. Am. Acad. Dermatol. 51: 257-264 (2004).
-
Smit JV, Franssen ME, de Jong EM, Lambert J, Roseeuw DI, De Weert J, Yocum RC, Stevens VJ, van De Kerkhof PC. A phase II multicenter clinical trial of systemic bexarotene in psoriasis.
J. Am. Acad. Dermatol. 51: 249-256 (2004).
-
Smit JW, Stokkel MP, Pereira AM, Romijn JA, Visser TJ. Bexarotene induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones.
J. Clin. Endocrinol. Metab. 92: 2496-2499 (2007).
*
-
Smith J, Bunaciu RP, Reiterer G, Coder D, George T, Asaly M, Yen A. Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.
Exp. Cell Res. 315: 2241-2248 (2009).
*
-
Smith SA. Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism.
Biochem. Soc. Trans. 30: 1086-1090 (2002).
*
-
Solomon C, Kremer R, White JH, Rhim JS. Vitamin D resistance in RAS-transformed keratinocytes: mechanism and reversal strategies.
Radiat. Res. 155: 156-162 (2001).
-
Solomon C, Macoritto M, Gao XL, White JH, Kremer R. The unique tryptophan residue of the vitamin D receptor is critical for ligand binding and transcriptional activation.
J. Bone Miner. Res. 16: 39-45 (2001).
-
Solomon C, Sebag M, White JH, Rhim J, Kremer R. Disruption of vitamin D receptor-retinoid X receptor heterodimer formation following ras transformation of human keratinocytes.
J. Biol. Chem. 273: 17573-17578 (1998).
*
-
Solomon C, White JH, Kremer R. Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha.
J. Clin. Invest. 103: 1729-1735 (1999).
*
-
Son YL, Lee YC. Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220.
Biochem. Biophys. Res. Commun. 384: 389-393 (2009).
*
-
Son YL, Park OG, Kim GS, Lee JW, Lee YC. RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal cointegrator-2.
Biochem. J. 410: 319-330 (2008).
*
-
Song C, Kokontis JM, Hiipakka RA, Liao S. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.
Proc. Natl. Acad. Sci. U.S.A. 91: 10809-10813 (1994).
*
-
Song CS, Echchgadda I, Baek BS, Ahn SC, Oh T, Roy AK, Chatterjee B. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor.
J. Biol. Chem. 276: 42549-42556 (2001).
*
-
Song CS, Echchgadda I, Seo YK, Oh T, Kim S, Kim SA, Cho S, Shi L, Chatterjee B. An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1).
Mol. Endocrinol. 20: 795-808 (2006).
*
-
Soprano DR, Soprano KJ. Pharmacological doses of some synthetic retinoids can modulate both the aryl hydrocarbon receptor and retinoid receptor pathways.
J. Nutr. 133: 277S-281S (2003).
*
-
Soprano KJ, Soprano DR. Retinoic acid receptors and cancer.
J. Nutr. 132: 3809S-3813S (2002).
*
-
Sorensen S, Solvsten H, Politi Y, Kragballe K. Effects of vitamin D3 on keratinocyte proliferation and differentiation in vitro: modulation by ligands for retinoic acid and retinoid X receptors.
Skin Pharmacol. 10: 144-152 (1997).
-
Sorg BL, Klan N, Seuter S, Dishart D, Radmark O, Habenicht A, Carlberg C, Werz O, Steinhilber D. Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.
Biochim. Biophys. Acta 1761: 686-697 (2006).
*
-
Souidi M, Gueguen Y, Linard C, Dudoignon N, Grison S, Baudelin C, Marquette C, Gourmelon P, Aigueperse J, Dublineau I. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat.
Toxicology 214: 113-122 (2005).
*
-
Spilianakis CG, Lee GR, Flavell RA. Twisting the Th1/Th2 immune response via the retinoid X receptor: lessons from a genetic approach.
Eur. J. Immunol. 35: 3400-3404 (2005).
*
-
Sporn MB, Suh N. Chemoprevention of cancer.
Carcinogenesis 21: 525-530 (2000).
*
-
Sprecher DL. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
Am. J. Cardiol. 100: S20-S24 (2007).
*
-
Staal A, van Wijnen AJ, Birkenhager JC, Pols HA, Prahl J, DeLuca H, Gaub MP, Lian JB, Stein GS, van Leeuwen JP, Stein JL. Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.
Mol. Endocrinol. 10: 1444-1456 (1996).
-
Staal A, Van Wijnen AJ, Desai RK, Pols HA, Birkenhager JC, Deluca HF, Denhardt DT, Stein JL, Van Leeuwen JP, Stein GS, Lian JB. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements.
Endocrinology 137: 2001-2011 (1996).
-
Stafslien DK, Vedvik KL, De Rosier T, Ozers MS. Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay.
Mol. Cell. Endocrinol. 264: 82-89 (2007).
-
Stebbins J, Jung D, Leone M, Zhang XK, Pellecchia M. A structure based approach to retinoid X receptor-alpha inhibition.
J. Biol. Chem. 281: 16643-16648 (2006).
*
-
Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schule R. All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.
Nat. Struct. Biol. 10: 820-825 (2003).
*
-
Steineger HH, Arntsen BM, Spydevold O, Sorensen HN. Gene transcription of the retinoid X receptor alpha (RXRalpha) is regulated by fatty acids and hormones in rat hepatic cells.
J. Lipid Res. 39: 744-754 (1998).
*
-
Steinmetz M, Quentin T, Poppe A, Paul T, Jux C. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac…
Basic Res. Cardiol. 100: 263-269 (2005).
*
-
Stephensen CB, Borowsky AD, Lloyd KC. Disruption of RXRa gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance.
Immunology 121: 484-498 (2007).
*
-
Stephensen CB, Rasooly R, Jiang X, Ceddia MA, Weaver CT, Chandraratna RA, Bucy RP. Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.
J. Immunol. 168: 4495-4503 (2002).
*
-
Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C, Morgan ET, Lichtenauer-Kaligis E, Kersten S, Muller M. The interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.
J. Hepatol. 46: 869-877 (2007).
*
-
Stoll BA. Linkage between retinoid and fatty acid receptors: implications for breast cancer prevention.
Eur. J. Cancer Prev. 11: 319-325 (2002).
-
Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.
Nucleic Acids Res. 35: 2177-2190 (2007).
*
-
Sturm E, Havinga R, Baller JF, Wolters H, van Rooijen N, Kamps JA, Verkade HJ, Karpen SJ, Kuipers F. Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats.
J. Hepatol. 42: 102-109 (2005).
*
-
Su D, Gudas LJ. Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.
Biochem. Pharmacol. 75: 1129-1160 (2008).
*
-
Su EJ, Cheng YH, Chatterton RT, Lin ZH, Yin P, Reierstad S, Innes J, Bulun SE. Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells.
Biol. Reprod. 77: 517-525 (2007).
*
-
Suchy FJ, Ananthanarayanan M. Bile salt excretory pump: biology and pathobiology.
J. Pediatr. Gastroenterol. Nutr. 43 Suppl. 1: S10-S16 (2006).
*
-
Sueyoshi T, Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors.
Annu. Rev. Pharmacol. Toxicol. 41: 123-143 (2001).
*
-
Sugatani J, Wada T, Osabe M, Yamakawa K, Yoshinari K, Miwa M. Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and HNF4alpha expression.
Drug Metab. Dispos. 34: 1677-1687 (2006).
*
-
Sugawara A, Uruno A, Nagata T, Taketo MM, Takeuchi K, Ito S. Characterization of mouse retinoid X receptor (RXR)-beta gene promoter: negative regulation by tumor necrosis factor (TNF)-alpha.
Endocrinology 139: 3030-3033 (1998).
*
-
Sugden MC, Holness MJ. Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.
Biochem. Soc. Trans. 36: 891-900 (2008).
*
-
Suhara W, Koide H, Okuzawa T, Hayashi D, Hashimoto T, Kojo H. Cow's milk increases the activities of human nuclear receptors peroxisome proliferator-activated receptors alpha and delta and retinoid X receptor alpha involved in the regulation of energy homeostasis, obesity, and inflammation.
J. Dairy Sci. 92: 4180-4187 (2009).
-
Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, Xu HE. The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.
Mol. Cell 16: 893-905 (2004).
*
-
Sukhai MA, Thomas M, Xuan Y, Chan LS, Hamadanizadeh SA, Zhang T, Bharadwaj RR, Schuh AC, Wells RA, Kamel-Reid S. Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia.
Oncogene 27: 4666-4677 (2008).
*
-
Sun D, Yang YM, Jiang H, Wu H, Ojaimi C, Kaley G, Huang A. Roles of CYP2C29 and RXRgamma in vascular EET synthesis of female mice.
Am. J. Physiol. Regul. Integr. Comp. Physiol. Feb 3 [Epub ahead of print] (2010).
*
-
Sun SY, Lotan R. Retinoids and their receptors in cancer development and chemoprevention.
Crit. Rev. Oncol. Hematol. 41: 41-55 (2002).
-
Sundar PD, Feingold E, Minster RL, Dekosky ST, Kamboh MI. Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease.
Neurobiol. Aging 28: 856-862 (2007).
-
Surapureddi S, Viswakarma N, Yu S, Guo D, Rao MS, Reddy JK. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.
Biochem. Biophys. Res. Commun. 343: 535-543 (2006).
*
-
Suruga K, Mochizuki K, Suzuki R, Goda T, Takase S. Regulation of cellular retinol-binding protein type II gene expression by arachidonic acid analogue and 9-cis retinoic acid in Caco-2 cells.
Eur. J. Biochem. 262: 70-78 (1999).
*
-
Sussman F, de Lera AR. Ligand recognition by RAR and RXR receptors: binding and selectivity.
J. Med. Chem. 48: 6212-6219 (2005).
*
-
Suzuki K, Takahashi K, Nishimaki-Mogami T, Kagechika H, Yamamoto M, Itabe H. Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.
Biol. Pharm. Bull. 32: 1177-1182 (2009).
*
-
Suzuki T, Nishimaki-Mogami T, Kawai H, Kobayashi T, Shinozaki Y, Sato Y, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Hayakawa T, Kawanishi T. Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
Phytomedicine 13: 401-411 (2006).
*
-
Svacina S. Metabolic PPAR receptors and skin.
Vnitr. Lek. 52: 451-453 (2006).
-
Svensson S, Ostberg T, Jacobsson M, Norstrom C, Stefansson K, Hallen D, Johansson IC, Zachrisson K, Ogg D, Jendeberg L. Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
EMBO J. 22: 4625-4633 (2003).
*
-
Sweeney TR, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy.
Am. J. Physiol. Endocrinol. Metab. 290: E1313-E1320 (2006).
*
-
Swift CB, Hays JL, Petty WJ. Distinct functions of retinoic acid receptor beta isoforms: implications for targeted therapy.
Endocr. Metab. Immune Disord. Drug Targets 8: 47-50 (2008).
-
Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions.
Cell Death Differ. 11 Suppl. 2: S126-S143 (2004).
*
-
Szatmari I, Vamosi G, Brazda P, Balint BL, Benko S, Szeles L, Jeney V, Ozvegy-Laczka C, Szanto A, Barta E, Balla J, Sarkadi B, Nagy L. Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells.
J. Biol. Chem. 281: 23812-23823 (2006).
*
-
Szondy Z, Reichert U, Bernardon JM, Michel S, Toth R, Karaszi E, Fesus L. Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha.
Biochem. J. 331: 767-774 (1998).
*
-
Szondy Z, Reichert U, Fesus L. Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors.
Cell Death Differ. 5: 4-10 (1998).
*
-
Szyld P, Jagiello P, Csernok E, Gross WL, Epplen JT. On the Wegener granulomatosis associated region on chromosome 6p21.3.
BMC Med. Genet. 7: 21 (2006).
*
-
Tabe Y. Molecular diagnosis of and molecular targeting therapy for leukemia.
Rinsho Byori 57: 137-145 (2009).
-
Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M. PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Cancer Biol. Ther. 6: 1967-1977 (2007).
-
Tachibana S, Yoshinari K, Chikada T, Toriyabe T, Nagata K, Yamazoe Y. Involvement of vitamin D receptor in the intestinal induction of human ABCB1.
Drug Metab. Dispos. 37: 1604-1610 (2009).
*
-
Tagami T, Lutz WH, Kumar R, Jameson JL. The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.
Biochem. Biophys. Res. Commun. 253: 358-363 (1998).
*
-
Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, Naruse M. The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.
J. Mol. Endocrinol. 42: 415-428 (2009).
*
-
Takada I, Kato S. PPARs target genes.
Nippon Rinsho 63: 573-577 (2005).
-
Takahashi N, Kawada T. Physiological and pharmacological function of PPARs.
Nippon Yakurigaku Zasshi 117: 319-327 (2001).
-
Takahashi Y, Inoue J, Kagechika H, Sato R. ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists.
FEBS Lett. 583: 493-497 (2009).
*
-
Takamatsu K, Takano A, Yakushiji N, Morishita KI, Matsuura N, Makishima M, Ali HI, Akaho E, Tai A, Sasaki K, Kakuta H. Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype-preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.
ChemMedChem. 3: 454-460 (2008).
*
-
Takamatsu K, Takano A, Yakushiji N, Morohashi K, Morishita KI, Matsuura N, Makishima M, Tai A, Sasaki K, Kakuta H. The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).
ChemMedChem. 3: 780-787 (2008).
*
-
Takano H, Hasegawa H, Zou Y, Komuro I. Pleiotropic actions of PPARgamma activators thiazolidinediones in cardiovascular diseases.
Curr. Pharm. Des. 10: 2779-2786 (2004).
-
Takano H, Komuro I. Peroxisome proliferator-activated receptor gamma and cardiovascular diseases.
Circ. J. 73: 214-220 (2009).
*
-
Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y. The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.
J. Biol. Chem. 279: 18926-18934 (2004).
*
-
Takase S, Suruga K, Goda T. Regulation of vitamin A metabolism-related gene expression.
Br. J. Nutr. 84 Suppl. 2: S217-S221 (2000).
-
Takeshita A, Ozawa Y, Chin WW. Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements.
Endocrinology 141: 1281-1284 (2000).
*
-
Takeyama K, Kodera Y, Suzawa M, Kato S. Peroxisome proliferator-activated receptor (PPAR) - structure, function, tissue distribution, gene expression.
Nippon Rinsho 58: 357-363 (2000).
-
Takiyama Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, Kobayashi H, Kimura S, Tateno M. Decreased expression of retinoid X receptor isoforms in human thyroid carcinomas.
J. Clin. Endocrinol. Metab. 89: 5851-5861 (2004).
*
-
Tallafuss A, Hale LA, Yan YL, Dudley L, Eisen JS, Postlethwait JH. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development.
Gene Expr. Patterns 6: 556-565 (2006).
*
-
Talukdar S, Hillgartner FB. The mechanism mediating the activation of acetyl-CoA carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
J. Lipid Res. 47: 2451-2461 (2006).
*
-
Tan KP, Kosuge K, Yang M, Ito S. NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity.
Free Radic. Biol. Med. 45: 1663-1673 (2008).
-
Tan NS, Michalik L, Desvergne B, Wahli W. Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes.
J. Steroid Biochem. Mol. Biol. 93: 99-105 (2005).
-
Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T. In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha.
FEBS Lett. 543: 120-124 (2003).
*
-
Tanaka T, De Luca LM. Therapeutic potential of "rexinoids" in cancer prevention and treatment.
Cancer Res. 69: 4945-4947 (2009).
*
-
Tanaka T, Suh KS, Lo AM, De Luca LM. p21WAF1/CIP1 is a common transcriptional target of retinoid receptors:pleiotropic regulatory mechanism through RAR/RXR heterodimer and RXR/RXR homodimer.
J. Biol. Chem. 282: 29987-29997 (2007).
*
-
Tanaka Y, Chen C, Maher JM, Klaassen CD. Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion.
Transplantation 82: 258-266 (2006).
-
Tang CK, Yi GH, Yang JH, Liu LS, Wang Z, Ruan CG, Yang YZ. Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages.
Acta Pharmacol. Sin. 25: 581-586 (2004).
*
-
Tang H, McLachlan A. Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3beta.
J. Virol. 76: 8572-8581 (2002).
*
-
Tang XH, Suh MJ, Li R, Gudas LJ. Cell proliferation inhibition and alterations in retinol esterification induced by phytanic acid and docosahexaenoic acid.
J. Lipid Res. 48: 165-176 (2007).
*
-
Tarrade A, Bastien J, Bruck N, Bauer A, Gianni M, Rochette-Egly C. Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha.
Oncogene 24: 2277-2288 (2005).
*
-
Taschner S, Koesters C, Platzer B, Jorgl A, Ellmeier W, Benesch T, Strobl H. Downregulation of RXRalpha expression is essential for neutrophil development from granulocyte/monocyte progenitors.
Blood 109: 971-979 (2007).
*
-
Tate BF, Levin AA, Grippo JF. The discovery of 9-cis retinoic acid: a hormone that binds the retinoid-X receptor.
Trends Endocrinol. Metab. 5: 189-194 (1994).
-
Tauscher A, Kuver R. ABCG5 and ABCG8 are expressed in gallbladder epithelial cells.
Biochem. Biophys. Res. Commun. 307: 1021-1028 (2003).
*
-
Tavva VS, Dinkins RD, Palli SR, Collins GB. Development of a tightly regulated and highly inducible ecdysone receptor gene switch for plants through the use of retinoid X receptor chimeras.
Transgenic Res. 16: 599-612 (2007).
*
-
Tazoe F, Yagyu H, Okazaki H, Igarashi M, Eto K, Nagashima SI, Inaba T, Shimano H, Osuga JI, Ishibashi S. Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.
Biochem. Biophys. Res. Commun. 376: 111-115 (2008).
*
-
Tchapyjnikov D, Li Y, Pisitkun T, Hoffert JD, Yu MJ, Knepper MA. Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS.
Physiol. Genomics Dec 8 [Epub ahead of print] (2009).
*
-
Tejerina S, De Pauw A, Vankoningsloo S, Houbion A, Renard P, De Longueville F, Raes M, Arnould T. Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma-dependent.
J. Cell Sci. 122: 145-155 (2009).
*
-
Tenno T, Botling J, Oberg F, Jossan S, Nilsson K, Siegbahn A. The role of RAR and RXR activation in retinoid-induced tissue factor suppression.
Leukemia 14: 1105-1111 (2000).
*
-
Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR. Active nuclear receptors exhibit highly correlated AF-2 domain motions.
PLoS Comput. Biol. 4: e1000111 (2008).
*
-
Terauchi Y. PPARgamma and metabolic syndrome.
Rinsho Byori 55: 447-451 (2007).
-
Teruel T, Hernandez R, Benito M, Lorenzo M. Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
J. Biol. Chem. 278: 263-269 (2003).
*
-
Thacher SM, Vasudevan J, Chandraratna RA. Therapeutic applications for ligands of retinoid receptors.
Curr. Pharm. Des. 6: 25-58 (2000).
-
Thompson PD, Hsieh JC, Whitfield GK, Haussler CA, Jurutka PW, Galligan MA, Tillman JB, Spindler SR, Haussler MR. Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor.
J. Cell. Biochem. 75: 462-480 (1999).
*
-
Thompson PD, Jurutka PW, Haussler CA, Whitfield GK, Haussler MR. Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions.
J. Biol. Chem. 273: 8483-8491 (1998).
*
-
Thompson PD, Remus LS, Hsieh JC, Jurutka PW, Whitfield GK, Galligan MA, Encinas Dominguez C, Haussler CA, Haussler MR. Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts.
J. Mol. Endocrinol. 27: 211-227 (2001).
*
-
Thompson RJ. The consequence of not being able to transport bile acids.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 60 (2006). *
-
Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz E. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
Mol. Pharmacol. 60: 1399-1406 (2001).
*
-
Thymiakou E, Zannis VI, Kardassis D. Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.
Biochemistry 46: 11473-11483 (2007).
*
-
Tippmann F, Hundt J, Schneider A, Endres K, Fahrenholz F. Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin.
FASEB J. 23: 1643-1654 (2009).
*
-
Tissandie E, Gueguen Y, Lobaccaro JM, Grandcolas L, Aigueperse J, Gourmelon P, Souidi M. Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney.
J. Steroid Biochem. Mol. Biol. 110: 263-268 (2008).
-
Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V. Structural and functional insights into the ligand binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus.
J. Biol. Chem. 284: 1938-1948 (2009).
*
-
Todorov VT, Desch M, Schmitt-Nilson N, Todorova A, Kurtz A. Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.
Hypertension 50: 939-944 (2007).
-
Toell A, Kroncke KD, Kleinert H, Carlberg C. Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands.
J. Cell. Biochem. 85: 72-82 (2002).
*
-
Tokar EJ, Ancrile BB, Ablin RJ, Webber MM. Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer.
J. Exp. Ther. Oncol. 5: 323-333 (2006).
-
Tokar EJ, Webber MM. Cholecalciferol (vitamin D(3)) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells.
Clin. Exp. Metastasis 22: 275-284 (2005).
*
-
Tokar EJ, Webber MM. Chemoprevention of prostate cancer by cholecalciferol (vitamin D(3)): 25-hydroxylase (CYP27A1) in human prostate epithelial cells.
Clin. Exp. Metastasis 22: 265-273 (2005).
*
-
Tokumoto M, Taniguchi M. The mechanisms of parathyroid hyperplasia and its regression.
Clin. Calcium 17: 665-676 (2007).
-
Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer binding proteins.
J. Biol. Chem. 284: 6116-6125 (2009).
*
-
Tomaru Y, Nakanishi M, Miura H, Kimura Y, Ohkawa H, Ohta Y, Hayashizaki Y, Suzuki M. Identification of an inter-transcription factor regulatory network in human hepatoma cells by matrix RNAi.
Nucleic Acids Res. 37: 1049-1060 (2009).
*
-
Tooker P, Yen WC, Ng SC, Negro-Vilar A, Hermann TW. Bexarotene (LGD1069, targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.
Cancer Res. 67: 4425-4433 (2007).
*
-
Toriyabe T, Nagata K, Takada T, Aratsu Y, Matsubara T, Yoshinari K, Yamazoe Y. Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics.
Mol. Pharmacol. 75: 677-684 (2009).
*
-
Torma H, Karlsson T, Michaelsson G, Rollman O, Vahlquist A. Decreased mRNA levels of retinoic acid receptor alpha, retinoid X receptor alpha and thyroid hormone receptor alpha in lesional psoriatic skin.
Acta Derm. Venereol. 80: 4-9 (2000).
-
Torra IP, Ismaili N, Feig JE, Xu CF, Cavasotto C, Pancratov R, Rogatsky I, Neubert TA, Fisher EA, Garabedian MJ. Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages.
Mol. Cell. Biol. 28: 2626-2636 (2008).
*
-
Toth B, Bastug M, Scholz C, Arck P, Schulze S, Kunze S, Friese K, Jeschke U. Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy.
Histol. Histopathol. 23: 1465-1475 (2008).
*
-
Touyz RM, Schiffrin EL. Peroxisome proliferator-activated receptors in vascular biology - molecular mechanisms and clinical implications.
Vascul. Pharmacol. 45: 19-28 (2006).
*
-
Tovar Sepulveda VA, Weigel NL, Falzon M. Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE.
Steroids 71: 102-115 (2006).
-
Traber MG. Vitamin E, nuclear receptors and xenobiotic metabolism.
Arch. Biochem. Biophys. 423: 6-11 (2004).
*
-
Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA. A regulatory role for RIP140 in nuclear receptor activation.
Mol. Endocrinol. 12: 864-881 (1998).
*
-
Tryggvason K, Romert A, Eriksson U. Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases.
J. Biol. Chem. 276: 19253-19258 (2001).
*
-
Tsao WC, Wu HM, Chi KH, Chang YH, Lin WW. Proteasome inhibitors induce peroxisome proliferator-activated receptor transactivation through RXR accumulation and a protein kinase C-dependent pathway.
Exp. Cell Res. 304: 234-243 (2005).
*
-
Tsujie M, Nakamori S, Okami J, Hayashi N, Hiraoka N, Nagano H, Dono K, Umeshita K, Sakon M, Monden M. Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.
Exp. Cell Res. 289: 143-151 (2003).
*
-
Tsujie M, Nakamori S, Okami J, Takahashi Y, Hayashi N, Nagano H, Dono K, Umeshita K, Sakon M, Monden M. Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.
Int. J. Oncol. 23: 325-331 (2003).
-
Tsukada M, Schroder M, Roos TC, Chandraratna RA, Reichert U, Merk HF, Orfanos CE, Zouboulis CC. 13-cis Retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors.
J. Invest. Dermatol. 115: 321-327 (2000).
*
-
Tsukamoto H, Hishinuma T, Tayama R, Narahara K, Suzuki N, Tomioka Y, Goto J. The induction of prostaglandin E synthase and upregulation of cyclooxygenase-2 by 9-cis retinoic acid.
Prostaglandins Other Lipid Mediat. 74: 61-74 (2004).
-
Tudor C, Feige JN, Pingali H, Bhushan Lohray V, Wahli W, Desvergne B, Engelborghs Y, Gelman L. Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells.
J. Biol. Chem. 282: 4417-4426 (2007).
*
-
Tummler B. Rescue of F508del CFTR: commentary on "F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive" [Biochim. Biohys. Acta Biomembranes ...].
Biochim. Biophys. Acta 1758: 563-564 (2006).
*
-
Turunen MM, Dunlop TW, Carlberg C, Vaisanen S. Selective use of multiple vitamin D response elements underlies the 1alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.
Nucleic Acids Res. 35: 2734-2747 (2007).
*
-
Tzameli I, Chua SS, Cheskis B, Moore DD. Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR.
Nucl. Recept. 1: 2 (2003).
*
-
Uchimura K, Nakamuta M, Enjoji M, Irie T, Sugimoto R, Muta T, Iwamoto H, Nawata H. Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells.
Hepatology 33: 91-99 (2001).
*
-
Uehara Y, Engel T, Li Z, Goepfert C, Rust S, Zhou X, Langer C, Schachtrup C, Wiekowski J, Lorkowski S, Assmann G, von Eckardstein A. Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.
Diabetes 51: 2922-2928 (2002).
*
-
Uehara Y, Miura SI, von Eckardstein A, Abe S, Fujii A, Matsuo Y, Rust S, Lorkowski S, Assmann G, Yamada T, Saku K. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.
Atherosclerosis 191: 11-21 (2007).
-
Ueki S, Mahemuti G, Oyamada H, Kato H, Kihara J, Tanabe M, Ito W, Chiba T, Takeda M, Kayaba H, Chihara J. Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis.
J. Immunol. 181: 7689-7698 (2008).
*
-
Ulven SM, Gundersen TE, Sakhi AK, Glover JC, Blomhoff R. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally.
Dev. Dyn. 222: 341-353 (2001).
*
-
Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A, Chihara K, Roeder RG, Matsui T. The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.
Genes Cells 10: 1127-1137 (2005).
*
-
Uray IP, Shen Q, Seo HS, Kim H, Lamph WW, Bissonnette RP, Brown PH. Rexinoid-induced expression of IGF binding protein-6 requires RARbeta -dependent permissive co-operation of retinoid receptors and AP-1.
J. Biol. Chem. 284: 345-353 (2009).
*
-
Urizar NL, Dowhan DH, Moore DD. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.
J. Biol. Chem. 275: 39313-39317 (2000).
*
-
Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.
Proc. Natl. Acad. Sci. U.S.A. 101: 17813-17818 (2004).
*
-
van de Kerkhof PC. Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology.
Dermatol. Ther. 19: 252-263 (2006).
*
-
van den Bemd GJ, Jhamai M, Staal A, van Wijnen AJ, Lian JB, Stein GS, Pols HA, van Leeuwen JP. A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands.
J. Biol. Chem. 277: 14539-14546 (2002).
*
-
van der Slik AR, van den Eng I, Eerligh P, Doxiadis II, Koeleman BP, Roep BO, Giphart MJ. Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.
Tissue Antigens 69: 348-353 (2007).
*
-
van Neerven S, Kampmann E, Mey J. RAR/RXR and PPAR/RXR signaling in neurological and psychiatric diseases.
Prog. Neurobiol. 85: 433-451 (2008).
-
van Neerven S, Mey J. RAR/RXR and PPAR/RXR signaling in spinal cord injury.
PPAR Res. 2007: 29275 (2007).
*
-
van Wageningen S, Breems-de Ridder MC, Nigten J, Nikoloski G, Erpelinck-Verschueren CA, Lowenberg B, de Witte T, Tenen DG, van der Reijden BA, Jansen JH. Gene transactivation without direct DNA-binding defines a novel gain-of-function for PML-RARalpha.
Blood 111: 1634-1643 (2008).
*
-
Vanden Heuvel JP. Cardiovascular disease-related genes and regulation by diet.
Curr. Atheroscler. Rep. 11: 448-455 (2009).
-
Vanden Heuvel JP, Thompson JT, Frame SR, Gillies PJ. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse and rat PPARalpha, beta, gamma, LXRbeta and RXRalpha.
Toxicol. Sci. 92: 476-489 (2006).
*
-
Varga G, Su C. Classification and predictive modeling of liver X receptor response elements.
BioDrugs 21: 117-124 (2007).
-
Vasku V, Bienertova Vasku J, Pavkova Goldbergova M, Vasku A. Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata.
Dermatology 214: 118-124 (2007).
-
Vatsyayan J, Lee SJ, Chang HY. Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
J. Biochem. Mol. Toxicol. 19: 279-288 (2005).
*
-
Vega VA, Anzulovich AC, Varas SM, Bonomi MR, Gimenez MS, Oliveros LB. Effect of nutritional vitamin A deficiency on lipid metabolism in the rat heart: its relation to PPAR gene expression.
Nutrition 25: 828-838 (2009).
*
-
Velasco LF, Togashi M, Walfish PG, de Paula Pessanha R, Moura FN, Barra GB, Nguyen P, Rebong R, Yuan C, Simeoni LA, Ribeiro RC, Baxter JD, Webb P, Neves FA. Thyroid hormone response element organization dictates the composition of active receptor.
J. Biol. Chem. 282: 12458-12466 (2007).
*
-
Venalainen T, Molnar F, Oostenbrink C, Carlberg C, Perakyla M. Molecular mechanism of allosteric communication in the human PPARalpha-RXRalpha heterodimer.
Proteins Sep 17 [Epub ahead of print] (2009).
*
-
Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
J. Biol. Chem. 275: 14700-14707 (2000).
*
-
Verlinden L, Verstuyf A, Quack M, Van Camp M, Van Etten E, De Clercq P, Vandewalle M, Carlberg C, Bouillon R. Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements.
J. Bone Miner. Res. 16: 625-638 (2001).
-
Verma AK. Retinoids in chemoprevention of cancer.
J. Biol. Regul. Homeost. Agents 17: 92-97 (2003).
-
Vernet N, Dennefeld C, Kloppfenstein M, Ruiz A, Bok D, Ghyselinck N, Mark M. Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation.
Reproduction 136: 619-626 (2008).
*
-
Vernet N, Dennefeld C, Rochette-Egly C, Oulad-Abdelghani M, Chambon P, Ghyselinck NB, Mark M. Retinoic acid metabolism and signalling pathways in the adult and developing mouse testis.
Endocrinology 147: 96-110 (2006).
*
-
Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: a pleiotropic hormone.
Kidney Int. Feb 24 [Epub ahead of print] (2010).
*
-
Vidal H. PPAR receptors: recent data.
Ann. Endocrinol. (Paris) 66: 5-9 (2005).
-
Vidal M, Ramana CV, Dusso AS. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Mol. Cell. Biol. 22: 2777-2787 (2002).
*
-
Villarroya F, Iglesias R, Giralt M. Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes.
Curr. Med. Chem. 11: 795-805 (2004).
-
Villeneuve LA, Gisbert E, Moriceau J, Cahu CL, Infante JL. Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax).
Br. J. Nutr. 95: 677-687 (2006).
*
-
Vivat-Hannah V, Bourguet W, Gottardis M, Gronemeyer H. Separation of retinoid X receptor homo- and heterodimerization functions.
Mol. Cell. Biol. 23: 7678-7688 (2003).
*
-
Vogel S, Piantedosi R, Frank J, Lalazar A, Rockey DC, Friedman SL, Blaner WS. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.
J. Lipid Res. 41: 882-893 (2000).
*
-
Volakakis N, Joodmardi E, Perlmann T. NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.
Biochem. Biophys. Res. Commun. 390: 1186-1191 (2009).
*
-
Volate SR, Muga SJ, Issa AY, Nitcheva D, Smith T, Wargovich MJ. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc(Min/+) mouse model of intestinal cancer.
Mol. Carcinog. 48: 920-933 (2009).
*
-
Vu-Dac N, Gervois P, Torra IP, Fruchart JC, Kosykh V, Kooistra T, Princen HM, Dallongeville J, Staels B. Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.
J. Clin. Invest. 102: 625-632 (1998).
*
-
Vu-Dac N, Schoonjans K, Kosykh V, Dallongeville J, Heyman RA, Staels B, Auwerx J. Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor.
Mol. Cell Biol. 16: 3350-3360 (1996).
*
-
Vucetic Z, Zhang Z, Zhao J, Wang F, Soprano KJ, Soprano DR. Acinus-S' represses RAR-regulated gene expression through interaction with the B-domain of RARs.
Mol. Cell. Biol. 28: 2549-2558 (2008).
*
-
Vyhlidal CA, Gaedigk R, Leeder JS. Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Drug Metab. Dispos. 34: 131-137 (2006).
*
-
Vyhlidal CA, Rogan PK, Leeder JS. Development and refinement of pregnane X receptor DNA binding site model using information theory: insights into PXR mediated gene regulation.
J. Biol. Chem. 279: 46779-46786 (2004).
*
-
Wagner CE, Jurutka PW, Marshall PA, Groy TL, van der Vaart A, Ziller JW, Furmick JK, Graeber ME, Matro E, Miguel BV, Tran IT, Kwon J, Tedeschi JN, Moosavi S, Danishyar A, Philp JS, Khamees RO, Jackson JN, Grupe DK, Badshah SL, Hart JW. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).
J. Med. Chem. 52: 5950-5966 (2009).
*
-
Wagner M, Zollner G, Trauner M. New molecular insights into the mechanisms of cholestasis.
J. Hepatol. 51: 565-580 (2009).
*
-
Wakabayashi KI, Okamura M, Tsutsumi S, Nishikawa N, Tanaka T, Sakakibara I, Kitakami JI, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets gene of histone modification enzyme PR-Set7/Setd8 and regulates adipogenesis through a positive feedback loop.
Mol. Cell. Biol. 29: 3544-3555 (2009).
*
-
Wallen-Mackenzie A, Mata de Urquiza A, Petersson S, Rodriguez FJ, Friling S, Wagner J, Ordentlich P, Lengqvist J, Heyman RA, Arenas E, Perlmann T. Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.
Genes Dev. 17: 3036-3047 (2003).
*
-
Walling HW, Swick BL, Gerami P, Scupham RK. Folliculotropic mycosis fungoides responding to bexarotene gel.
J. Drugs Dermatol. 7: 169-171 (2008).
-
Walter L, Fischer K, Gunther E. Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex.
Immunogenetics 44: 218-221 (1996).
-
Wan H, Dawson MI, Hong WK, Lotan R. Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells.
J. Biol. Chem. 273: 26915-26922 (1998).
*
-
Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
Mol. Cell. Biol. 20: 4436-4444 (2000).
*
-
Wan YJ, Badr MZ. Inhibition of carrageenan-induced cutaneous inflammation by PPAR agonists is dependent on hepatocyte-specific retinoid X receptor alpha.
PPAR Res. 2006: 96341 (2006).
*
-
Wan YJ, Cai Y, Lungo W, Fu P, Locker J, French S, Sucov HM. Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice.
J. Biol. Chem. 275: 28285-28290 (2000).
*
-
Wan YJ, Han G, Cai Y, Dai T, Konishi T, Leng AS. Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance.
Endocrinology 144: 605-611 (2003).
*
-
Wan YJ, Morimoto M, Thurman RG, Bojes HK, French SW. Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease.
Life Sci. 56: 307-317 (1995).
-
Wan YJ, Pan T, Wang L, Locker J, Wu TC. 9-cis-Retinoic acid is more effective than all-trans-retinoic acid in upregulating expression of the alpha-fetoprotein gene.
J. Mol. Endocrinol. 14: 101-108 (1995).
-
Wan YY, Cai Y, Li J, Yuan Q, French B, Gonzalez FJ, French S. Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice.
Hepatol. Res. 19: 117-130 (2001).
-
Wang FW, Wen L, Zhu SW, Yao Q, Cai YM, Ma G. Mechanism of wnt signaling pathway regulation by a truncated mutant of axin2 in colorectal cancer.
Ai Zheng 26: 1041-1046 (2007).
-
Wang H, Chu W, Hemphill C, Hasstedt SJ, Elbein SC. Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes.
Mol. Genet. Metab. 76: 14-22 (2002).
*
-
Wang JL, Swartz-Basile DA, Rubin DC, Levin MS. Retinoic acid stimulates early cellular proliferation in the adapting remnant rat small intestine after partial resection.
J. Nutr. 127: 1297-1303 (1997).
*
-
Wang K, Chen S, Xie W, Wan YJ. Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway.
Biochem. Pharmacol. 75: 2204-2213 (2008).
*
-
Wang K, Mendy AJ, Dai G, Luo HR, Lin H, Wan YJ. Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.
Toxicol. Sci. 92: 51-60 (2006).
*
-
Wang K, Wan YJ. Nuclear receptors and inflammatory diseases.
Exp. Biol. Med. (Maywood) 233: 496-506 (2008).
*
-
Wang L, Potter JJ, Rennie-Tankersley L, Novitskiy G, Sipes J, Mezey E. Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice.
Biochim. Biophys. Acta 1772: 66-71 (2006).
*
-
Wang Q, Herrera-Ruiz D, Mathis AS, Cook TJ, Bhardwaj RK, Knipp GT. Expression of PPAR, RXR isoforms and fatty acid transporting proteins in the rat and human gastrointestinal tracts.
J. Pharm. Sci. 94: 363-372 (2005).
*
-
Wang T, Xu J, Yu X, Yang R, Han ZC. Peroxisome proliferator-activated receptor gamma in malignant diseases.
Crit. Rev. Oncol. Hematol. 58: 1-14 (2006).
-
Wang X, Wang TT, White JH, Studzinski GP. Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamn D(3) and is required for optimal cell differentiation.
Exp. Cell Res. 313: 3034-3045 (2007).
*
-
Wang Y, Bell JC, Keeney DS, Strobel HW. Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.
Drug Metab. Dispos. 38: 100-107 (2010).
*
-
Wang Y, Kurdi-Haidar B, Oram JF. LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.
J. Lipid Res. 45: 972-980 (2004).
*
-
Wang Y, Liu YB, Jiang ZY, Cai Q, Jiang ZH, Han TQ, Zhang SD. Expression and regulation of megalin in gallbladder mucosa associated with cholesterol gallstone disease.
Zhonghua Yi Xue Za Zhi 89: 1110-1113 (2009).
-
Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Down-regulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.
J. Lipid Res. 46: 2377-2387 (2005).
*
-
Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M. Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide.
Mol. Cancer Ther. 5: 1060-1072 (2006).
*
-
Wang YH, Leblanc GA. Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor.
Mol. Cell. Endocrinol. 309: 109-116 (2009).
-
Wang YH, Wang G, Leblanc GA. Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna.
Gen. Comp. Endocrinol. 150: 309-318 (2007).
*
-
Watanabe Y, Tanaka T, Uchiyama Y, Takeno T, Izumi A, Yamashita H, Kumakura J, Iwanari H, Shu-Ying J, Naito M, Mangelsdorf DJ, Hamakubo T, Kodama T. Establishment of a monoclonal antibody for human LXRalpha: detection of LXRalpha protein expression in human macrophages.
Nucl. Recept. 1: 1 (2003).
*
-
Waxman DJ. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.
Arch. Biochem. Biophys. 369: 11-23 (1999).
*
-
Waxman DJ. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.
J. Endocrinol. 150: S129-S147 (1996).
-
Waxman JS, Yelon D. Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.
Dev. Dyn. 236: 587-595 (2007).
*
-
Wei LN. Retinoids and receptor interacting protein 140 (RIP140) in gene regulation.
Curr. Med. Chem. 11: 1527-1532 (2004).
-
Weinhofer I, Kunze M, Rampler H, Bookout AL, Forss-Petter S, Berger J. Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression: novel cross-talk in gene regulation.
J. Biol. Chem. 280: 41243-41251 (2005).
*
-
Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM. Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin secreting cells.
Endocrinology 148: 1843-1849 (2007).
*
-
Westin S, Kurokawa R, Nolte RT, Wisely GB, McInerney EM, Rose DW, Milburn MV, Rosenfeld MG, Glass CK. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators.
Nature 395: 199-202 (1998).
*
-
White JA, Boffa MB, Jones B, Petkovich M. A zebrafish retinoic acid receptor expressed in the regenerating caudal fin.
Development 120: 1861-1872 (1994).
*
-
White JA, Guo YD, Baetz K, Beckett-Jones B, Bonasoro J, Hsu KE, Dilworth FJ, Jones G, Petkovich M. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.
J. Biol. Chem. 271: 29922-29927 (1996).
*
-
Whitfield GK, Hsieh JC, Jurutka PW, Selznick SH, Haussler CA, MacDonald PN, Haussler MR. Genomic actions of 1,25-dihydroxyvitamin D3.
J. Nutr. 125: 1690S-1694S (1995).
*
-
Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.
J. Biol. Chem. 276: 43509-43515 (2001).
*
-
Wieczorek S, Knaup S, Gross WL, Epplen JT. Genetic variability of RXRB, PPARA, and PPARG in Wegener's granulomatosis.
PPAR Res. 2009: 786781 (2009).
*
-
Williams SJ, Cvetkovic D, Hamilton TC. Vitamin A metabolism is impaired in human ovarian cancer.
Gynecol. Oncol. 112: 637-645 (2009).
-
Willy PJ, Mangelsdorf DJ. Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.
Genes Dev. 11: 289-298 (1997).
*
-
Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Genes Dev. 9: 1033-1045 (1995).
*
-
Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.
EMBO J. 25: 3089-3099 (2006).
*
-
Wistuba W, Gnewuch C, Liebisch G, Schmitz G, Langmann T. Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR.
World J. Gastroenterol. 13: 4230-4235 (2007).
*
-
Wohlfahrt G, Sipila J, Pietila LO. Field-based comparison of ligand and co-activator binding sites of nuclear receptors.
Biopolymers 91: 884-894 (2009).
-
Wojcicka G, Jamroz-Wisniewska A, Horoszewicz K, Beltowski J. Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism.
Postepy. Hig. Med. Dosw. (Online) 61: 736-759 (2007).
*
-
Wolf G. Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?
Nutr. Rev. 64: 532-538 (2006).
*
-
Wolf G. Cellular retinoic acid-binding protein II: a coactivator of the transactivation by the retinoic acid receptor complex RAR.RXR.
Nutr. Rev. 58: 151-53 (2000).
-
Wolfrum C, Borrmann CM, Borchers T, Spener F. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.
Proc. Natl. Acad. Sci. U.S.A. 98: 2323-2328 (2001).
*
-
Wood RJ. Vitamin D and adipogenesis: new molecular insights.
Nutr. Rev. 66: 40-46 (2008).
*
-
Woods CG, Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity.
Toxicol. Pathol. 35: 474-494 (2007).
*
-
Wright E, Vincent J, Fernandez EJ. Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry.
Biochemistry 46: 862-870 (2007).
*
-
Wrutniak-Cabello C, Carazo A, Casas F, Cabello G. Triiodothyronine mitochondrial receptors: import and molecular mechanisms.
J. Soc. Biol. 202: 83-92 (2008).
-
Wu CW, Yu J, Sung JJ. Peroxisome proliferator-activated receptor delta and gastric cancer (review).
Oncol. Rep. 22: 451-457 (2009).
-
Wu JB, Chen K, Ou XM, Shih JC. Retinoic acid activates monoamine oxidase B promoter in human neuronal cells.
J. Biol. Chem. 284: 16723-16735 (2009).
*
-
Wu K, Dupre E, Kim H, Tin-U CK, Bissonnette RP, Lamph WW, Brown PH. Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade.
Breast Cancer Res. Treat. 96: 147-157 (2006).
*
-
Wu Q, Dawson MI, Zheng Y, Hobbs PD, Agadir A, Jong L, Li Y, Liu R, Lin B, Zhang XK. Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids.
Mol. Cell. Biol. 17: 6598-6608 (1997).
*
-
Wu Y, Guo SW. Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells.
Fertil. Steril. 91: S2142-S2147 (2009).
-
Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver.
Mol. Pharmacol. 65: 550-557 (2004).
*
-
Xiao JH, Durand B, Chambon P, Voorhees JJ. Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers …
J. Biol. Chem. 270: 3001-3011 (1995).
*
-
Xu C, Li CY, Kong AN. Induction of phase I, II and III drug metabolism/transport by xenobiotics.
Arch. Pharm. Res. 28: 249-268 (2005).
-
Xu DX, Wang JP, Sun MF, Chen YH, Wei W. Lipopolysaccharide downregulates the expressions of intestinal pregnane X receptor and cytochrome P450 3a11.
Eur. J. Pharmacol. 536: 162-170 (2006).
*
-
Xu J, Chavis JA, Racke MK, Drew PD. Peroxisome proliferator-activated receptor-alpha and retinoid X receptor agonists inhibit inflammatory responses of astrocytes.
J. Neuroimmunol. 176: 95-105 (2006).
-
Xu J, Storer PD, Chavis JA, Racke MK, Drew PD. Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
J. Neurosci. Res. 81: 403-411 (2005).
*
-
Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.
Mol. Cell. 16: 919-928 (2004).
*
-
Xu XC. Tumor-suppressive activity of retinoic acid receptor-beta in cancer.
Cancer Lett. 253: 14-24 (2007).
*
-
Xu XC, Wong WY, Goldberg L, Baer SC, Wolf JE, Ramsdell WM, Alberts DS, Lippman SM, Lotan R. Progressive decreases in nuclear retinoid receptors during skin squamous carcinogenesis.
Cancer Res. 61: 4306-4310 (2001).
*
-
Xu ZK, Chen NG, Ma CY, Meng ZX, Sun YJ, Han X. Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion.
Acta Biochim. Biophys. Sin. (Shanghai) 38: 1-7 (2006).
-
Xue Y, Fleet JC. Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice.
Gastroenterology 136: 1317-1327.e2 (2009).
*
-
Yagishita N, Yamamoto Y, Yoshizawa T, Sekine K, Uematsu Y, Murayama H, Nagai Y, Krezel W, Chambon P, Matsumoto T, Kato S. Aberrant growth plate development in VDR/RXR gamma double null mutant mice.
Endocrinology 142: 5332-5341 (2001).
*
-
Yajima H, Kobayashi Y, Kanaya T, Horino Y. Identification of peroxisome-proliferator responsive element in the mouse HSL gene.
Biochem. Biophys. Res. Commun. 352: 526-531 (2007).
*
-
Yamada PM, Lee KW. Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.
Am. J. Physiol. Cell. Physiol. 296: C954-C976 (2009).
*
-
Yamaguchi S, Murata Y, Nagaya T, Hayashi Y, Ohmori S, Nimura Y, Seo H. Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes.
J. Mol. Endocrinol. 22: 81-90 (1999).
*
-
Yamamoto Y, Zolfaghari R, Ross AC. Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats.
FASEB J. 14: 2119-2127 (2000).
*
-
Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K, Miki H, Kubota N, Terauchi Y, Tsuchida A, Tsuboyama-Kasaoka N, Yamauchi N, Ide T, Hori W, Kato S, Fukayama M, Akanuma Y, Ezaki O, Itai A, Nagai R, Kimura S, Tobe K, Kagechika H, Shudo K, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
J. Clin. Invest. 108: 1001-1013 (2001).
*
-
Yamazaki K, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Kanemura N, Araki H, Tsurumi H, Kojima S, Weinstein IB, Moriwaki H. Synergistic effects of RXRalpha and PPARgamma ligands to inhibit growth in human colon cancer cells - phosphorylated RXRalpha is a critical target for colon cancer management.
Gut 56: 1557-1563 (2007).
*
-
Yamazaki Y, Kawano Y, Uebayasi M. Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid.
Life Sci. 82: 290-300 (2008).
*
-
Yan DS, Zhou XT, Chen XY, Lu F, Wang J, Hu DN, Qu J. Expression of retinoid acid receptors in human scleral fibroblasts and regulation of growth of fibroblasts by retinoic acid.
Zhonghua Yan Ke Za Zhi 43: 750-753 (2007).
-
Yan X, Perez E, Leid M, Schimerlik MI, de Lera AR, Deinzer ML. Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD.
Protein Sci. 16: 2491-2501 (2007).
*
-
Yan ZH, Karam WG, Staudinger JL, Medvedev A, Ghanayem BI, Jetten AM. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.
J. Biol. Chem. 273: 10948-10957 (1998).
*
-
Yanase T, Mu YM, Nishi Y, Goto K, Nomura M, Okabe T, Takayanagi R, Nawata H. Regulation of aromatase by nuclear receptors.
J. Steroid Biochem. Mol. Biol. 79: 187-192 (2001).
-
Yang T, Michele DE, Park J, Smart AM, Lin Z, Brosius FC 3rd, Schnermann JB, Briggs JP. Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney.
Am. J. Physiol. 277: F966-F973 (1999).
*
-
Yang W, Rachez C, Freedman LP. Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.
Mol. Cell. Biol. 20: 8008-8017 (2000).
*
-
Yang WL, Frucht H. Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.
Carcinogenesis 22: 1379-1383 (2001).
*
-
Yang X, Guo M, Wan YJ. Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers.
Am. J. Pathol. Dec 24 [Epub ahead of print] (2009).
*
-
Yang Y, Minucci S, Ozato K, Heyman RA, Ashwell JD. Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors.
J. Biol. Chem. 270: 18672-18677 (1995).
*
-
Yang Y, Vacchio MS, Ashwell JD. 9-cis-Retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.
Proc. Natl. Acad. Sci. U.S.A. 90: 6170-6174 (1993).
*
-
Yang YZ, Subauste JS, Koenig RJ. Retinoid X receptor alpha binds with the highest affinity to an imperfect direct repeat response element.
Endocrinology 136: 2896-2903 (1995).
*
-
Yasmin R, Williams RM, Xu M, Noy N. Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer.
J. Biol. Chem. 280: 40152-40160 (2005).
*
-
Ye X, Tao Q, Wang Y, Cheng Y, Lotan R. Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.
Cancer Biol. Ther. 8: 951-962 (2009).
-
Yen PM, Liu Y, Sugawara A, Chin WW. Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity.
J. Biol. Chem. 271: 10910-10916 (1996).
*
-
Yin HQ, Kim YS, Choi YJ, Kim YC, Sohn DH, Ryu SY, Lee BH. Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease.
Arch. Pharm. Res. 31: 659-665 (2008).
-
Ying H, Araki O, Furuya F, Kato Y, Cheng SY. Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.
Mol. Cell. Biol. 27: 2359-2371 (2007).
*
-
Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR…
Mol. Endocrinol. 17: 1240-1254 (2003).
*
-
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Mol. Cell. Biol. 21: 2991-3000 (2001).
*
-
Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
J. Biol. Chem. 277: 1705-1711 (2002).
*
-
Yoshimura K, Muto Y, Shimizu M, Matsushima-Nishiwaki R, Okuno M, Takano Y, Tsurumi H, Kojima S, Okano Y, Moriwaki H. Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta.
Cancer Sci. 98: 1868-1874 (2007).
*
-
Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA. Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.
Proc. Natl. Acad. Sci. U.S.A. 106: 2441-2446 (2009).
*
-
Yu S, Cao WQ, Kashireddy P, Meyer K, Jia Y, Hughes DE, Tan Y, Feng J, Yeldandi AV, Rao MS, Costa RH, Gonzalez FJ, Reddy JK. Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.
J. Biol. Chem. 276: 42485-42491 (2001).
*
-
Yu S, Kong AN. Targeting carcinogen metabolism by dietary cancer preventive compounds.
Curr. Cancer Drug Targets 7: 416-424 (2007).
-
Yu S, Reddy JK. Transcription coactivators for peroxisome proliferator-activated receptors.
Biochim. Biophys. Acta 1771: 936-951 (2007).
*
-
Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.
Cell 67: 1251-1266 (1991).
-
Yue L, Ye F, Gui C, Luo H, Cai J, Shen J, Chen K, Shen X, Jiang H. Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation.
Protein Sci. 14: 812-822 (2005).
*
-
Yumuk VD. Targeting components of the stress system as potential therapies for the metabolic syndrome: the peroxisome-proliferator-activated receptors.
Ann. N. Y. Acad. Sci. 1083: 306-318 (2006).
*
-
Zamule SM, Strom SC, Omiecinski CJ. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes.
Chem. Biol. Interact. 173: 179-186 (2008).
*
-
Zanotto-Filho A, Cammarota M, Gelain DP, Oliveira RB, Delgado-Canedo A, Dalmolin RJ, Pasquali MA, Moreira JC. Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation.
Toxicol. In Vitro 22: 1205-1212 (2008).
-
Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, de Madariaga A, Domingo JC. 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities …
J. Immunol. 178: 6130-6139 (2007).
*
-
Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J, de Madariaga MA, Domingo JC. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARgamma:RXR heterodimers - comparison with other polyunsaturated fatty acids.
J. Leukoc. Biol. 84: 1172-1182 (2008).
*
-
Zappala G, Elbi C, Edwards J, Gorenstein J, Rechler MM, Bhattacharyya N. Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha.
Endocrinology 149: 1802-1812 (2008).
*
-
Zappala G, Rechler MM. IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription.
Biochem. Biophys. Res. Commun. 382: 785-789 (2009).
*
-
Zavacki AM, Lehmann JM, Seol W, Willson TM, Kliewer SA, Moore DD. Activation of the orphan receptor RIP14 by retinoids.
Proc. Natl. Acad. Sci. U.S.A. 94: 7909-7914 (1997).
*
-
Zeisig BB, Kwok C, Zelent A, Shankaranarayanan P, Gronemeyer H, Dong S, So CW. Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.
Cancer Cell 12: 36-51 (2007).
-
Zella LA, Kim S, Shevde NK, Pike JW. Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D(3).
J. Steroid Biochem. Mol. Biol. 103: 435-439 (2007).
-
Zella LA, Kim S, Shevde NK, Pike JW. Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3.
Mol. Endocrinol. 20: 1231-1247 (2006).
*
-
Zella LA, Meyer MB, Nerenz RD, Lee SM, Martowicz ML, Pike JW. Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.
Mol. Endocrinol. 24: 128-147 (2010).
*
-
Zeng M, Zhang Y, Bhat I, Wazer DE, Band H, Band V. The human kallikrein 10 promoter contains a functional retinoid response element.
Biol. Chem. 387: 741-747 (2006).
-
Zhang DE, Hetherington CJ, Gonzalez DA, Chen HM, Tenen DG. Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.
J. Immunol. 153: 3276-3284 (1994).
-
Zhang J, Hu X, Lazar MA. A novel role for helix 12 of retinoid X receptor in regulating repression.
Mol. Cell. Biol. 19: 6448-6457 (1999).
*
-
Zhang Q, Bae Y, Kemper JK, Kemper B. Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.
Arch. Biochem. Biophys. 451: 119-127 (2006).
*
-
Zhang QY. Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.
Biochem. Biophys. Res. Commun. 256: 346-351 (1999).
*
-
Zhang W, Purchio A, Chen K, Burns SM, Contag CH, Contag PR. In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors.
Biochem. Pharmacol. 65: 1889-1896 (2003).
*
-
Zhang X, Zhu Z, Luo G, Zheng L, Nilsson-Ehle P, Xu N. Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro.
Biochem. Biophys. Res. Commun. 371: 114-117 (2008).
*
-
Zhang XK. Targeting Nur77 translocation.
Expert Opin. Ther. Targets 11: 69-79 (2007).
-
Zhang XK, Lehmann J, Hoffmann B, Dawson MI, Cameron J, Graupner G, Hermann T, Tran P, Pfahl M. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
Nature 358: 587-591 (1992).
*
-
Zhang XK, Salbert G, Lee MO, Pfahl M. Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.
Mol. Cell. Biol. 14: 4311-4323 (1994).
*
-
Zhang Y, Beyer TP, Bramlett KS, Yao S, Burris TP, Schmidt RJ, Eacho PI, Cao G. Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.
Mol. Genet. Metab. 77: 150-158 (2002).
*
-
Zhang Y, Repa JJ, Gauthier K, Mangelsdorf DJ. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.
J. Biol. Chem. 276: 43018-43024 (2001).
*
-
Zhang Y, Yin L, Hillgartner FB. Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element.
J. Biol. Chem. 276: 974-983 (2001).
*
-
Zhang-Gandhi CX, Drew PD. Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes.
J. Neuroimmunol. 183: 50-59 (2007).
-
Zhao A, Lew JL, Huang L, Yu J, Zhang T, Hrywna Y, Thompson JR, de Pedro N, Blevins RA, Pelaez F, Wright SD, Cui J. Human kininogen gene is transactivated by the farnesoid X receptor.
J. Biol. Chem. 278: 28765-28770 (2003).
*
-
Zhao J, Zhang Z, Vucetic Z, Soprano KJ, Soprano DR. HACE1: a novel repressor of RAR transcriptional activity.
J. Cell. Biochem. 107: 482-493 (2009).
*
-
Zhao Q, Chasse SA, Devarakonda S, Sierk ML, Ahvazi B, Rastinejad F. Structural basis of RXR-DNA interactions.
J. Mol. Biol. 296: 509-520 (2000).
*
-
Zhelyaznik N, Mey J. Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury.
Neuroscience 141: 1761-1774 (2006).
*
-
Zhong C, Yang S, Huang J, Cohen MB, Roy-Burman P. Aberration in the expression of the retinoid receptor, RXRalpha, in prostate cancer.
Cancer Biol. Ther. 2: 179-184 (2003).
*
-
Zhou D, Ghebremeskel K, Crawford MA, Reifen R. Vitamin A deficiency enhances docosahexaenoic and osbond acids in liver of rats fed an alpha linolenic acid-adequate diet.
Lipids 41: 213-219 (2006).
-
Zhou D, Zaiger G, Ghebremeskel K, Crawford MA, Reifen R. Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet.
Prostaglandins Leukot. Essent. Fatty Acids 71: 383-389 (2004).
*
-
Zhou L, Choi HY, Li WP, Xu F, Herz J. LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export.
PLoS One 4: e6853 (2009).
*
-
Zhou L, Shen LH, Hu LH, Ge H, Pu J, Chai DJ, Shao Q, Wang L, Zeng JZ, He B. Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.
Mol. Cell. Biochem. Sep 27 [Epub ahead of print] (2009).
*
-
Zhou Y, Wang J, Malloy PJ, Dolezel Z, Feldman D. Compound heterozygous mutations in the vitamin D receptor in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia.
J. Bone Miner. Res. 24: 643-651 (2009).
*
-
Zhu GH, Huang J, Bi Y, Su Y, Tang Y, He BC, He Y, Luo J, Wang Y, Chen L, Zuo GW, Jiang W, Luo Q, Shen J, Liu B, Zhang WL, Shi Q, Zhang BQ, Kang Q, Zhu J, Tian J, Luu HH, Haydon RC, Chen Y, He TC. Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells.
Differentiation 78: 195-204 (2009).
*
-
Zhu J, Nasr R, Peres L, Riaucoux-Lormiere F, Honore N, Berthier C, Kamashev D, Zhou J, Vitoux D, Lavau C, de The H. RXR is an essential component of the oncogenic PML/RARA complex in vivo.
Cancer Cell 12: 23-35 (2007).
-
Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR).
Cardiovasc. Res. 68: 425-432 (2005).
*
-
Zhuang R, Lin M, Napoli JL. cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells.
Biochemistry 41: 3477-3483 (2002).
*
-
Zierold C, DeLuca HF. Additional protein factors play a role in the formation of VDR/RXR complexes on vitamin D response elements.
J. Cell. Biochem. 71: 515-523 (1998).
*
-
Zimber A, Gespach C. Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential.
Anticancer Agents Med. Chem. 8: 540-563 (2008).
-
Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.
J. Biol. Chem. 281: 15434-15440 (2006).
*
-
Zingarelli B, Cook JA. Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation.
Shock 23: 393-399 (2005).
*
-
Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J. Retinaldehyde represses adipogenesis and diet-induced obesity.
Nat. Med. 13: 695-702 (2007).
*
-
Ziouzenkova O, Orashanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky J. Asymmetric cleavage of beta-carotene yields a transcriptional repressor of RXR and PPAR responses.
Mol. Endocrinol. 21: 77-88 (2007).
*
-
Ziouzenkova O, Plutzky J. Retinoid metabolism and nuclear receptor responses: new insights into coordinated regulation of the PPAR-RXR complex.
FEBS Lett. 582: 32-38 (2008).
*
-
Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA. Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.
J. Immunol. 152: 1419-1427 (1994).
-
Zoete V, Grosdidier A, Michielin O. Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.
Biochim. Biophys. Acta 1771: 915-925 (2007).
*
-
Zolfaghari R, Ross AC. An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.
Arch. Biochem. Biophys. 489: 1-9 (2009).
*
-
Zollner G, Wagner M, Fickert P, Geier A, Fuchsbichler A, Silbert D, Gumhold J, Zatloukal K, Kaser A, Tilg H, Denk H, Trauner M. Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
Am. J. Physiol. Gastrointest. Liver Physiol. 289: G798-G805 (2005).
*
-
Zollner G, Wagner M, Fickert P, Silbert D, Gumhold J, Zatloukal K, Denk H, Trauner M. Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.
Liver Int. 27: 920-929 (2007).
*
-
Zordoky BN, El-Kadi AO. Role of NF-kappaB in the regulation of cytochrome p450 enzymes.
Curr. Drug Metab. 10: 164-178 (2009).
-
Zorrilla S, Garzon B, Perez-Sala D. Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to PPARgamma allows ligand identification and characterization.
Anal. Biochem. Dec 15 [Epub ahead of print] (2009).
*
-
Zou A, Elgort MG, Allegretto EA. Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.
J. Biol. Chem. 272: 19027-19034 (1997).
*
-
Zouboulis CC. Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy.
J. Eur. Acad. Dermatol. Venereol. 15 Suppl. 3: 63-67 (2001).
-
Zouboulis CC. Retinoids - which dermatological indications will benefit in the near future?
Skin Pharmacol. Appl. Skin Physiol. 14: 303-315 (2001).
-
Zuzarte M, Heusser K, Renigunta V, Schlichthorl G, Rinne S, Wischmeyer E, Daut J, Schwappach B, Preisig-Muller R. Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins.
J. Physiol. 587: 929-952 (2009).
*
Number of references = 1576
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David and Judy Rhodes
Last Update: 3/1/2010
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