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Scientific Literature, PSTI or SPINK1
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Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid.
J. Immunol. 174: 5874-5883 (2005).
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Aoun E, Muddana V, Papachristou GI, Whitcomb DC. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event.
Am. J. Gastroenterol. Nov 3 [Epub ahead of print] (2009).
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Aoun E, Slivka A, Papachristou DJ, Gleeson FC, Whitcomb DC, Papachristou GI. Rapid evolution from the first episode of acute pancreatitis to chronic pancreatitis in human subjects.
JOP 8: 573-578 (2007).
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Apte MV, Pirola RC, Wilson JS. Individual susceptibility to alcoholic pancreatitis.
J. Gastroenterol. Hepatol. 23 Suppl. 1: S63-S68 (2008).
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Arduino C, Salacone P, Pasini B, Brusco A, Salmin P, Bacillo E, Robecchi A, Cestino L, Cirillo S, Regge D, Cappello N, Gaia E. Association of a new cationic trypsinogen gene mutation (V39A) with chronic pancreatitis in an Italian family.
Gut 54: 1663-1664 (2005).
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Arveiler B, Petkovich M, Mandel JL, Chambon P. A PstI RFLP for the human retinoic acid receptor in 17q21.
Nucleic Acids Res. 16: 6252 (1988).
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Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T. Analysis of humoral immune response in experimental autoimmune pancreatitis in mice.
Pancreas Oct 2 [Epub ahead of print] (2009).
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Audrezet MP, Chen JM, Le Marechal C, Ruszniewski P, Robaszkiewicz M, Raguenes O, Quere I, Scotet V, Ferec C. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis.
Eur. J. Hum. Genet. 10: 100-106 (2002).
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Bak D, Sobczynska-Tomaszewska A, Bal J. Hereditary aspects of pancreatitis.
Med. Wieku. Rozwoj. 7: 57-66 (2003).
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Balog A, Gal J, Gyulai Z, Zsilak S, Mandi Y. Tumour necrosis factor-alpha and heat-shock protein 70-2 gene polymorphisms in a family with rheumatoid arthritis.
Acta Microbiol. Immunol. Hung. 51: 263-269 (2004).
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Balog A, Gyulai Z, Boros LG, Farkas G, Takacs T, Lonovics J, Mandi Y. Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis.
Pancreas 30: e46-e50 (2005).
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Bastian HM, Alarcon GS, Roseman JM, McGwin G Jr, Vila LM, Fessler BJ, Reveille JD. Systemic lupus erythematosus in a multiethnic US cohort (LUMINA) XL II: factors predictive of new or worsening proteinuria.
Rheumatology (Oxford) 46: 683-689 (2007).
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Beranek H, Teich N, Witt H, Schulz HU, Mossner J, Keim V. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis.
Eur. J. Gastroenterol. Hepatol. 15: 1223-1227 (2003).
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Bernardino AL, Guarita DR, Mott CB, Pedroso MR, Machado MC, Laudanna AA, Tani CM, Almeida FL, Zatz M. CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients.
JOP 4: 169-177 (2003).
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Bhaskar S, Reddy DN, Mahurkar S, Rao GV, Singh L, Chandak GR. Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.
BMC Gastroenterol. 6: 42 (2006).
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Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.
Gastroenterology 123: 1020-1025 (2002).
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Borrego S, Casals T, Dapena J, Fernandez E, Gimenez J, Cabeza JC, Sanchez J, Antinolo G. Molecular and clinical analyses of cystic fibrosis in the south of Spain.
Clin. Genet. 46: 287-290 (1994).
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Bougacha-Elleuch N, Tamouza R, Bellassouad M, Jouida J, Abid M, Maalej A, Makni H, Ayadi H. Analysis of heat shock protein polymorphisms in a large family with autoimmune thyroid diseases.
Arch. Inst. Pasteur Tunis. 77: 23-24 (2000).
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Caprilli R. Why does Crohn's disease usually occur in terminal ileum?
Journal of Crohn's and Colitis 2: 352-356 (2008).
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Chandak GR, Idris MM, Reddy DN, Bhaskar S, Sriram PV, Singh L. Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis.
J. Med. Genet. 39: 347-351 (2002).
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Chandak GR, Idris MM, Reddy DN, Mani KR, Bhaskar S, Rao GV, Singh L. Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis.
Gut 53: 723-728 (2004).
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Chang YT, Chang MC, Su TC, Liang PC, Su YN, Kuo CH, Wei SC, Wong JM. Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis.
Clin. Chem. 54: 131-138 (2008).
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Chang YT, Wei SC, L PC, Tien YW, Jan IS, Su YN, Wong JM, Chang MC. Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects.
Gut 58: 885 (2009).
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Chen JM, Ferec C. The true culprit within the SPINK1 p.N34S-containing haplotype is still at large.
Gut 58: 478-480 (2009).
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Chen JM, Ferec C. Chronic pancreatitis: genetics and pathogenesis.
Annu. Rev. Genomics Hum. Genet. 10: 63-87 (2009).
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Chen JM, Mercier B, Audrezet MP, Ferec C. Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis.
J. Med. Genet. 37: 67-69 (2000).
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Chen JM, Mercier B, Audrezet MP, Raguenes O, Quere I, Ferec C. Mutations of the pancreatic secretory trypsin inhibitor (PSTI) gene in idiopathic chronic pancreatitis.
Gastroenterology 120: 1061-1064 (2001).
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Cohn JA. Motion - genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments against the motion.
Can. J. Gastroenterol. 17: 53-55 (2003).
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Cohn JA. Reduced CFTR function and the pathobiology of idiopathic pancreatitis.
J. Clin. Gastroenterol. 39: S70-S77 (2005).
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Cohn JA, Mitchell RM, Jowell PS. The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis.
Clin. Lab. Med. 25: 79-100 (2005).
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Cohn JA, Noone PG, Jowell PS. Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.
J. Investig. Med. 50: 247S-255S (2002).
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Cosan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoglu F, Saruhan-Direskeneli G, Ustek D, Gul A. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behcet's disease.
Clin. Rheumatol. 28: 1385-1388 (2009).
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Cox SE, Doherty C, Atkinson SH, Nweneka CV, Fulford AJ, Ghattas H, Rockett KA, Kwiatkowski DP, Prentice AM. Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection.
PLoS ONE 2: e362 (2007).
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Debler J, Schiemann U, Seybold U, Mussack T, Landauer N, Ladurner R, Gross M. Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.
Eur. J. Med. Res. 8: 120-124 (2003).
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Drenth JP, te Morsche R, Jansen JB. Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.
Gut 50: 687-692 (2002).
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Ellis I. Genetic counseling for hereditary pancreatitis - the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1.
Gastroenterol. Clin. North Am. 33: 839-854 (2004).
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Esaki M, Furuse M, Matsumoto T, Aoyagi K, Jo Y, Yamagata H, Nakano H, Fujishima M. Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease.
Scand. J. Gastroenterol. 34: 703-707 (1999).
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Felderbauer P, Hoffmann P, Einwachter H, Bulut K, Ansorge N, Schmitz F, Schmidt WE. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations.
BMC Gastroenterol. 3: 34 (2003).
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Felderbauer P, Karakas E, Fendrich V, Bulut K, Horn T, Lebert R, Holland-Letz T, Schmitz F, Bartsch D, Schmidt WE. Pancreatitis risk in primary hyperparathyroidism: relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fibrosis gene.
Am. J. Gastroenterol. 103: 368-374 (2008).
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Felderbauer P, Klein W, Bulut K, Ansorge N, Dekomien G, Werner I, Epplen JT, Schmitz F, Schmidt WE. Mutations in the calcium-sensing receptor: a new genetic risk factor for chronic pancreatitis?
Scand. J. Gastroenterol. 41: 343-348 (2006).
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Fernando MM, Isenberg DA. Conversion of discoid lupus to antiphospholipid syndrome and SLE.
Nat. Clin. Pract. Rheumatol. 4: 106-110 (2008).
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Fleming RE, Britton RS, Waheed A, Sly WS, Bacon BR. Pathogenesis of hereditary hemochromatosis.
Clin. Liver Dis. 8: 755-773, vii (2004).
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Frulloni L, Scattolini C, Graziani R, Cavestro GM, Pravadelli C, Amodio A, Manfredi R, Scarpa A, Vantini I. Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations.
Pancreas 37: 371-376 (2008).
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Gaia E, Salacone P, Gallo M, Promis GG, Brusco A, Bancone C, Carlo A. Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients.
Dig. Dis. Sci. 47: 2416-2421 (2002).
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Garg PK, Khajuria R, Kabra M, Shastri SS. Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis.
J. Clin. Gastroenterol. Jul 10 [Epub ahead of print] (2009).
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Gattas GJ, de Carvalho MB, Siraque MS, Curioni OA, Kohler P, Eluf-Neto J, Wunsch-Filho V. Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.
Head Neck 28: 819-826 (2006).
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Gomez-Lira M, Bonamini D, Castellani C, Unis L, Cavallini G, Assael BM, Pignatti PF. Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients.
Eur. J. Hum. Genet. 11: 543-546 (2003).
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Gonzalez A, Ramirez V, Cuenca P, Sierra R. Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility.
Rev. Biol. Trop. 52: 591-600 (2004).
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Grocock CJ, Rebours V, Delhaye M, Andren-Sandberg A, Weiss FU, Mountford R, Harcus M, Niemczyck E, Vitone L, Dodd S, Joergensen MT, Ammann RW, Schaffalitzky de Muckadell O, Butler JV, Burgess P, Kerr B, Charnley R, Sutton R, Raraty M, Deviere J, et al. The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families.
Gut Dec 1 [Epub ahead of print] (2009).
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Gundling F, Reitmeier F, Tannapfel A, Schutz A, Weber A, Ussmuller J, Keim V, Mossner J, Teich N. Chronic parotitis: not another SPINKosis.
Dig. Dis. 22: 292-295 (2004).
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Hanck C, Schneider A, Whitcomb DC. Genetic polymorphisms in alcoholic pancreatitis.
Best Pract. Res. Clin. Gastroenterol. 17: 613-623 (2003).
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Hassan Z, Mohan V, Ali L, Allotey R, Barakat K, Faruque MO, Deepa R, McDermott MF, Jackson AE, Cassell P, Curtis D, Gelding SV, Vijayaravaghan S, Gyr N, Whitcomb DC, Khan AK, Hitman GA. SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent.
Am. J. Hum. Genet. 71: 964-968 (2002).
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Hirota M, Kuwata K, Ohmuraya M, Ogawa M. From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene.
JOP 4: 83-88 (2003).
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Howes N, Greenhalf W, Stocken DD, Neoptolemos JP. Cationic trypsinogen mutations and pancreatitis.
Gastroenterol. Clin. North Am. 33: 767-787 (2004).
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Hubacek JA, Pitha J, Skodova Z, Adamková V, Podrapska I, Schmitz G, Poledne R. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction.
Clin. Chem. Lab. Med. 40: 1097-1100 (2002).
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Hubacek JA, Stuber F, Frohlich D, Book M, Wetegrove S, Ritter M, Rothe G, Schmitz G. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis.
Crit. Care Med. 29: 557-561 (2001).
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Ishii T, Onda H, Tanigawa A, Ohshima S, Fujiwara H, Mima T, Katada Y, Deguchi H, Suemura M, Miyake T, Miyatake K, Kawase I, Zhao H, Tomiyama Y, Saeki Y, Nojima H. Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
DNA Res. 12: 429-439 (2005).
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Jhavar S, Brewer D, Edwards S, Kote-Jarai Z, Attard G, Clark J, Flohr P, Christmas T, Thompson A, Parker M, Shepherd C, Stenman UH, Marchbank T, Playford RJ, Woodhouse C, Ogden C, Fisher C, Kovacs G, Corbishley C, Jameson C, Norman A, De-Bono J, et al. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer.
BJU Int. 103: 1256-1269 (2009).
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Joergensen M, Brusgaard K, Cruger DG, Gerdes AM, de Muckadell OB. Incidence, prevalence, etiology, and prognosis of first-time chronic pancreatitis in young patients: a nationwide cohort study.
Dig. Dis. Sci. Jan 28 [Epub ahead of print] (2010).
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Kalinin VN, Kaifi JT, Schwarzenbach H, Sergeyev AS, Link BC, Bogoevski D, Vashist Y, Izbicki JR, Yekebas EF. Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients.
World J. Gastroenterol. 12: 5352-5356 (2006).
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Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A. Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.
J. Hum. Genet. 46: 293-297 (2001).
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Keiles S, Kammesheidt A. Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis.
Pancreas 33: 221-227 (2006).
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Keim V. Chronic pancreatitis - pancreas cancer: influence of genetic factors.
Schweiz. Rundsch. Med. Prax. 94: 811-817 (2005).
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Keim V. Role of genetic disorders in acute recurrent pancreatitis.
World J. Gastroenterol. 14: 1011-1015 (2008).
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Keim V. Genetics of pancreatitis.
Scand. J. Surg. 94: 103-107 (2005).
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Keim V. Identification of patients with genetic risk factors of pancreatitis: impact on treatment and cancer prevention.
Dig. Dis. 21: 346-350 (2003).
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Keim V, Witt H, Bauer N, Bodeker H, Rosendahl J, Teich N, Mossner J. The course of genetically determined chronic pancreatitis.
JOP 4: 146-154 (2003).
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Kereszturi E, Kiraly O, Sahin-Toth M. Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis.
Gut 58: 545-549 (2009).
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Kim CD. Pancreatitis - etiology and pathogenesis.
Korean J. Gastroenterol. 46: 321-332 (2005).
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Kim YT. Hereditary pancreatitis.
Korean J. Gastroenterol. 45: 143-147 (2005).
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Kiraly O, Boulling A, Witt H, Le Marechal C, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Toth M, Ferec C. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis.
Hum. Mutat. 28: 469-476 (2007).
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Kitahara K, Kawa S, Katsuyama Y, Umemura T, Ozaki Y, Takayama M, Arakura N, Ota M. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
Dis. Markers 25: 175-180 (2008).
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Kobayashi K, Atoh M, Yagita A, Konoeda Y, Inoko H, Ando A, Sekiguchi S. Crohn's disease in the Japanese is associated with the HLA-DRw53.
Exp. Clin. Immunogenet. 7: 101-108 (1990).
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Komatsu M, Yazaki M, Tanaka N, Sano K, Hashimoto E, Takei YI, Song YZ, Tanaka E, Kiyosawa K, Saheki T, Aoyama T, Kobayashi K. Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease.
J. Hepatol. 49: 810-820 (2008).
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Kume K, Masamune A, Kikuta K, Shimosegawa T. [-215G>A; IVS3+2T>C] mutation in the SPINK1 gene causes exon 3 skipping and loss of the trypsin binding site.
Gut 55: 1214 (2006).
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Kume K, Masamune A, Mizutamari H, Kaneko K, Kikuta K, Satoh M, Satoh K, Kimura K, Suzuki N, Nagasaki Y, Horii A, Shimosegawa T. Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis.
Pancreatology 5: 354-360 (2005).
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Kuwata K, Hirota M, Nishimori I, Otsuki M, Ogawa M. Mutational analysis of the pancreatic secretory trypsin inhibitor gene in familial and juvenile pancreatitis in Japan.
J. Gastroenterol. 38: 365-370 (2003).
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Kuwata K, Hirota M, Shimizu H, Nakae M, Nishihara S, Takimoto A, Mitsushima K, Kikuchi N, Endo K, Inoue M, Ogawa M. Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution.
J. Gastroenterol. 37: 928-934 (2002).
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Kuwata K, Hirota M, Sugita H, Kai M, Hayashi N, Nakamura M, Matsuura T, Adachi N, Nishimori I, Ogawa M. Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis.
J. Gastroenterol. 36: 612-618 (2001).
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Lamprecht G, Mau UA, Kortum C, Raible A, Stern M, Riebeta O, Gregor M. Relapsing pancreatitis due to a novel compound heterozygosity in the CFTR gene involving the second most common mutation in Central and Eastern Europe [CFTRdele2,3(21 kb)].
Pancreatology 5: 92-96 (2005).
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Lara LF, Levy MJ. Idiopathic recurrent acute pancreatitis.
MedGenMed. 6: 10 (2004).
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Le Marechal C, Chen JM, Le Gall C, Plessis G, Chipponi J, Chuzhanova NA, Raguenes O, Ferec C. Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis.
Hum. Mutat. 23: 205 (2004).
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Lee KH, Ryu JK, Yoon WJ, Lee JK, Kim YT, Yoon YB. Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis.
Dig. Dis. Sci. 50: 1852-1856 (2005).
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Lee KH, Yoon WJ, Ryu JK, Kim YT, Yoon YB, Kim CY. Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis.
Korean J. Gastroenterol. 44: 93-98 (2004).
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Lempinen M, Paju A, Kemppainen E, Smura T, Kylanpaa ML, Nevanlinna H, Stenman J, Stenman UH. Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.
Scand. J. Gastroenterol. 40: 225-230 (2005).
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Lerch MM, Halangk W. Human pancreatitis and the role of cathepsin B.
Gut 55: 1228-1230 (2006).
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Liddle RA. Susceptibility to pancreatitis related to PSTI/SPINK1 expression.
Gastroenterol. Clin. North Am. 33: 807-816 (2004).
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Lindley KJ. Chronic pancreatitis.
Indian J. Pediatr. 73: 907-912 (2006).
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Lohr JM. What are the useful biological and functional markers of early-stage chronic pancreatitis?
J. Gastroenterol. 42 Suppl. 17: 66-71 (2007).
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Lucrezio L, Bassi M, Migliori M, Bastagli L, Gullo L. Alcoholic pancreatitis: new pathogenetic insights.
Minerva Med. 99: 391-398 (2008).
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Mahurkar S, Bhaskar S, Reddy DN, Prakash S, Rao GV, Singh SP, Thomas V, Chandak GR. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.
BMC Med. Genet. 9: 80 (2008).
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Mahurkar S, Bhaskar S, Reddy DN, Rao GV, Chandak GR. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.
World J. Gastroenterol. 13: 5938-5943 (2007).
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Mahurkar S, Idris MM, Reddy ND, Bhaskar S, Rao VG, Thomas V, Singh L, Chandak GR. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.
Gut 55: 1270-1275 (2006).
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Maire F, Levy P, Rebours V, Hammel P, Ruszniewski P. From the chronic pancreatitis to chronic pancreatites.
Gastroenterol. Clin. Biol. 33: 725-736 (2009).
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Maruyama K, Harada S, Yokoyama A, Mizukami S, Naruse S, Hirota M, Nishimori I, Otsuki M. Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan.
Alcohol. Clin. Exp. Res. 34 Suppl. 1: S34-S38 (2010).
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Masamune A, Mizutamari H, Kume K, Asakura T, Satoh K, Shimosegawa T. Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S.
Pancreas 28: 305-310 (2004).
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Masson E, Le Marechal C, Chen JM, Frebourg T, Lerebours E, Ferec C. Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene.
Eur. J. Hum. Genet. 14: 1204-1208 (2006).
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Masson E, Marechal CL, Levy P, Chuzhanova N, Ruszniewski P, Cooper DN, Chen JM, Ferec C. Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) in a family with chronic pancreatitis.
Mol. Genet. Metab. 92: 168-175 (2007).
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Matsubayashi H, Fukushima N, Sato N, Brune K, Canto M, Yeo CJ, Hruban RH, Kern SE, Goggins M. Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.
Cancer Biol. Ther. 2: 652-655 (2003).
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Mobius P, Luyven G, Hotzel H, Kohler H. High genetic diversity among Mycobacterium avium subsp. paratuberculosis strains of German cattle herds shown by combination of IS900 RFLP analysis and MIRU-VNTR typing.
J. Clin. Microbiol. 46: 972-981 (2008).
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Muddana V, Lamb J, Greer JB, Elinoff B, Hawes RH, Cotton PB, Anderson MA, Brand RE, Slivka A, Whitcomb DC. Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol.
World J. Gastroenterol. 14: 4486-4491 (2008).
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Murugaian EE, Premkumar RM, Radhakrishnan L, Vallath B. Novel mutations in the calcium sensing receptor gene in tropical chronic pancreatitis in India.
Scand. J. Gastroenterol. 43: 117-121 (2008).
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Mwantembe O, Gaillard MC, Barkhuizen M, Pillay V, Berry SD, Dewar JB, Song E. Ethnic differences in allelic associations of the interleukin-1 gene cluster in South African patients with inflammatory bowel disease (IBD) and in control individuals.
Immunogenetics 52: 249-254 (2001).
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Nakano I, Funakoshi A, Sumii T, Miyazaki K, Oogami Y, Kimura T, Ibayashi H. Appearance mechanism and molecular heterogeneity of serum pancreatic secretory trypsin inhibitor (PSTI).
Gastroenterol. Jpn. 20: 354-360 (1985).
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Nam SY, Kim N, Kim JS, Lim SH, Jung HC, Song IS. Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease.
J. Gastroenterol. Hepatol. 22: 1032-1038 (2007).
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Naruse S, Fujiki K, Ishiguro H. Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage?
J. Gastroenterol. 42 Suppl. 17: 60-65 (2007).
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Nathan JD, Romac J, Peng RY, Peyton M, Macdonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
Gastroenterology 128: 717-727 (2005).
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Noone PG, Zhou Z, Silverman LM, Jowell PS, Knowles MR, Cohn JA. Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations.
Gastroenterology 121: 1310-1319 (2001).
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O'Reilly DA, Witt H, Rahman SH, Schulz HU, Sargen K, Kage A, Cartmell MT, Landt O, Larvin M, Demaine AG, McMahon MJ, Becker M, Kingsnorth AN. The SPINK1 N34S variant is associated with acute pancreatitis.
Eur. J. Gastroenterol. Hepatol. 20: 726-731 (2008).
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Ockenga J, Dork T, Stuhrmann M. Low prevalence of SPINK1 gene mutations in adult patients with chronic idiopathic pancreatitis.
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David and Judy Rhodes
Last Update: 2/28/2010
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