• Bowlus CL, Karlsen TH, Broome U, Thorsby E, Vatn M; the IBSEN study group; Schrumpf E, Lie BA, Boberg KM. Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. J. Hepatol. 45: 704-710 (2006). *

• Eike MC, Nordang GB, Karlsen TH, Boberg KM, Vatn MH; IBSEN study group, Dahl-Jorgensen K, Ronningen KS, Joner G, Flato B, Bergquist A, Thorsby E, Forre O, Kvien TK, Undlien DE, Lie BA. The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases. Ann. Rheum. Dis. 67: 1287-1291 (2008).

• Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjoras M, Boberg KM, Alseth I. Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. Carcinogenesis 30: 1147-1154 (2009). *

• Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat. Genet. 40: 713-715 (2008). *

• Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 40: 1319-1323 (2008). *

• Franke A, Rosenstiel P, Balschun T, Von Kampen O, Schreiber S, Sina C, Hampe J, Karlsen TH, Vatn MH; The IBSEN Study Group; Solberg C. No association between the TUCAN (CARD8) Cys10 stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample. Gastroenterology 132: 2080-2081 (2007). *

• Franke A, Ruether A, Wedemeyer N, Karlsen TH, Nebel A, Schreiber S. No association between the functional CARD4 insertion/deletion polymorphism and inflammatory bowel diseases in the German population. Gut 55: 1679-1680 (2006). *

• Hov JR, Boberg KM, Karlsen TH. Autoantibodies in primary sclerosing cholangitis. World J. Gastroenterol. 14: 3781-3791 (2008). *

• Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P. Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. J. Hepatol. [In Press] (2010).

• Karlsen TH. Genome-wide association studies reach hepatology. J. Hepatol. 50: 1278-1280 (2009).

• Karlsen TH, Boberg KM, Olsson M, Sun JY, Senitzer D, Bergquist A, Schrumpf E, Thorsby E, Lie BA. Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis. J. Hepatol. 46: 899-906 (2007). *

• Karlsen TH, Boberg KM, Schrumpf E. Role of polymorphisms in genes involved in bile acid detoxification pathways in primary sclerosing cholangitis. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 87 (2006). *

• Karlsen TH, Boberg KM, Vatn M, Bergquist A, Hampe J, Schrumpf E, Thorsby E, Schreiber S, Lie BA. Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis. Genes Immun. 8: 275-278 (2007). *

• Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismuller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma R, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 138: 1102-1111 (2010). *

• Karlsen TH, Hampe J, Wiencke K, Schrumpf E, Thorsby E, Lie BA, Broome U, Schreiber S, Boberg KM. Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis. Am. J. Gastroenterol. 102: 115-121 (2007). *

• Karlsen TH, Hov JR. Genetics of cholestatic liver disease in 2010. Curr. Opin. Gastroenterol. Dec 29 [Epub ahead of print] (2009). *

• Karlsen TH, Lie BA, Frey Froslie K, Thorsby E, Broome U, Schrumpf E, Boberg KM. Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis. Gastroenterology 131: 781-787 (2006). *

• Karlsen TH, Melum E, Franke A. The utility of genome-wide association studies in hepatology. Hepatology [In Press] (2010). *

• Karlsen TH, Schrumpf E, Boberg KM. Genetic epidemiology of primary sclerosing cholangitis. World J. Gastroenterol. 13: 5421-5431 (2007). *

• Karlsen TH, Schrumpf E, Boberg KM. Gallbladder polyps in primary sclerosing cholangitis: not so benign. Curr. Opin. Gastroenterol. 24: 395-399 (2008).

• Karlsen TH, Schrumpf E, Boberg KM. Update on primary sclerosing cholangitis. Dig. Liver Dis. Feb 19 [Epub ahead of print] (2010). *

• Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. Ann. Neurol. 65: 658-666 (2009).

• Melum E, Franke A, Karlsen TH. Genome-wide association studies - a summary for the clinical gastroenterologist. World J. Gastroenterol. 15: 5377-5396 (2009). *

• Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM. An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis. Am. J. Gastroenterol. 103: 1045 (2008). *

• Melum E, Karlsen TH, Broome U, Thorsby E, Schrumpf E, Boberg KM, Lie BA. The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. Tissue Antigens 68: 78-81 (2006). *

• Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA. Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms. Hepatology 47: 90-96 (2008). *

• Scholz T, Karlsen TH, Sanengen T, Schrumpf E, Foss A, Line PD, Boberg KM, Jorgensen PF, Fosby B, Bentdal O, Ostensen AB, Osnes S, Riddervold F, Haugaa H, Hausken J, Bergmann JB, Foss S, Bjoro K. Liver transplantation in Norway through 25 years. Tidsskr. Nor. Laegeforen. 129: 2587-2592 (2009).

• Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A. Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. Tissue Antigens 69: 161-169 (2007). *

• Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcon-Riquelme ME, Schreiber S, Ibrahim SM. Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases. Genes Immun. 10: 601-605 (2009).

Number of references = 29

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