• Aarvak T, Chabaud M, Miossec P, Natvig JB. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162: 1246-1251 (1999). *

• Abadja F, Videcoq C, Alamartine E, Berthoux F, Mariat C. Differential effect of cyclosporine and mycophenolic acid on the human regulatory T cells and Th-17 cells balance. Transplant. Proc. 41: 3367-3370 (2009). *

• Abdollahi-Roodsaz S, Joosten LA, Helsen MM, Walgreen B, van Lent PL, van den Bersselaar LA, Koenders MI, van den Berg WB. Shift from Toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum. 58: 3753-3764 (2008). *

• Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ, Ribeiro-Dias F, van den Berg WB. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J. Clin. Invest. 118: 205-216 (2008). *

• Abdulahad WH, Stegeman CA, Kallenberg CG. Review article: the role of CD4(+) T cells in ANCA-associated systemic vasculitis. Nephrology (Carlton) 14: 26-32 (2009). *

• Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG. Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. Arthritis Rheum. 58: 2196-2205 (2008). *

• Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, Hirose S. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB x NZB) F(1) male mice: a new mouse model. Mod. Rheumatol. 19: 316-322 (2009). *

• Abebe F, Mustafa T, Nerland AH, Bjune GA. Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. Clin. Exp. Immunol. 143: 180-192 (2006). *

• Abediankenari S, Shaker D, Abedian F, Mirabi A. The effect of beta interferon on dendritic cells and cytokine synthesis by CD4+ T cells. Iran J. Immunol. 6: 61-66 (2009).

• Abraham C, Cho J. Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm. Bowel Dis. 15: 1090-1100 (2009). *

• Abreu JR, Dontje W, Krausz S, de Launay D, van Hennik PB, van Stalborch AM, Ten Klooster JP, Sanders ME, Reedquist KA, Hordijk PL, Vervoordeldonk MJ, Tak PP. A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res. Ther. 12: R2 (2010). *

• Abromson-Leeman S, Bronson RT, Dorf ME. Encephalitogenic T cells that stably express both T-bet and RORgammat consistently produce IFNgamma but have a spectrum of IL-17 profiles. J. Neuroimmunol. 215: 10-24 (2009).

• Abromson-Leeman S, Ladell DS, Bronson RT, Dorf ME. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J. Neuroimmunol. 192: 3-12 (2007). *

• Achkar JP, Duerr R. The expanding universe of inflammatory bowel disease genetics. Curr. Opin. Gastroenterol. 24: 429-434 (2008). *

• Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8: 942-949 (2007). *

• Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, Sallusto F, Napolitani G. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8: 639-646 (2007). *

• Adamopoulos IE, Chao CC, Geissler R, Laface D, Blumenschein W, Iwakura Y, McClanahan T, Bowman EP. Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. Arthritis Res. Ther. 12: R29 (2010). *

• Adamus G, Karren LJ, Mooney J, Burrows GG. A promising therapeutic approach for treatment of posterior uveitis: recombinant T cell receptor ligand protects Lewis rats from acute and recurrent experimental autoimmune uveitis. Ophthalmic Res. 44: 24-33 (2010).

• Adler EM. IL-2 antagonizes Th17 differentiation. Sci. STKE 379: tw103 (2007).

• Afif H, Benderdour M, Mfuna-Endam L, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H. Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is down-regulated by interleukin-1beta in articular chondrocytes. Arthritis Res. Ther. 9: R31 (2007). *

• Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 148: 32-46 (2007). *

• Afzali B, Mitchell P, Lechler RI, John S, Lombardi G. Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin. Exp. Immunol. 159: 120-130 (2010). *

• Agarwal S, Misra R, Aggarwal A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J. Rheumatol. 35: 515-519 (2008). *

• Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278: 1910-1914 (2003). *

• Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71: 1-8 (2002). *

• Agger EM, Cassidy JP, Brady J, Korsholm KS, Vingsbo-Lundberg C, Andersen P. Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection. Immunology 124: 175-185 (2008). *

• Ahmad SM, Haskell MJ, Raqib R, Stephensen CB. Markers of innate immune function are associated with vitamin A stores in men. J. Nutr. 139: 377-385 (2009). *

• Ainola M, Mandelin J, Liljestrom M, Konttinen YT, Salo J. Imbalanced expression of RANKL and osteoprotegerin mRNA in pannus tissue of rheumatoid arthritis. Clin. Exp. Rheumatol. 26: 240-246 (2008).

• Ainsworth DM, Wagner B, Franchini M, Grunig G, Erb HN, Tan JY. Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction. Am. J. Vet. Res. 67: 669-677 (2006).

• Akaogi J, Nozaki T, Satoh M, Yamada H. Role of PGE2 and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy. Endocr. Metab. Immune Disord. Drug Targets 6: 383-394 (2006).

• Akilov OE, Ustyugova IV, Zhi L, Hasan T, Wu MX. Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1. J. Immunol. 183: 7994-8003 (2009).

• Akimzhanov AM, Yang XO, Dong C. Chromatin remodeling at interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282: 5969-5972 (2007). *

• Albanesi C, Cavani A, Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J. Immunol. 162: 494-502 (1999). *

• Albanesi C, Scarponi C, Cavani A, Federici M, Nasorri F, Girolomoni G. Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J. Invest. Dermatol. 115: 81-87 (2000). *

• Alber G, Al-Robaiy S, Kleinschek M, Knauer J, Krumbholz P, Richter J, Schoeneberger S, Schuetze N, Schulz S, Toepfer K, Voigtlaender R, Lehmann J, Mueller U. Induction of immunity and inflammation by interleukin-12 family members. Ernst Schering Res. Found. Workshop 56: 107-127 (2006).

• Albertsmeyer AC, Kakkassery V, Spurr-Michaud S, Beeks O, Gipson IK. Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells. Exp. Eye Res. Dec 23 [Epub ahead of print] (2009). *

• Albright CA, Sartor RB, Tonkonogy SL. Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria. Immunol. Lett. 123: 77-87 (2009).

• Alex P, Ye M, Zachos NC, Sipes J, Nguyen T, Suhodrev M, Gonzales L, Arora Z, Zhang T, Centola M, Guggino SE, Li X. Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis. J. Immunol. Feb 24 [Epub ahead of print] (2010).

• Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, Centola M, Li X. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm. Bowel Dis. 15: 341-352 (2009). *

• Alexander D, Friedrich B, Abruzzese T, Gondolph-Zink B, Wulker N, Aicher WK. The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression. Cell. Physiol. Biochem. 17: 69-78 (2006). *

• Alfano M, Crotti A, Vicenzi E, Poli G. New players in cytokine control of HIV infection. Curr. HIV/AIDS Rep. 5: 27-32 (2008).

• Algood HM, Allen SS, Washington MK, Peek RM Jr, Miller GG, Cover TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J. Immunol. 183: 5837-5846 (2009).

• Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M. TLR2-activated human Langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol. 39: 1221-1230 (2009). *

• Allegra A, Alonci A, Bellomo G, D'Angelo A, Granata A, Russo S, Quartarone E, Musolino C. Evaluation of interleukin-17 serum levels in patients with chronic myeloproliferative diseases. Tumori. 95: 404-405 (2009).

• Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HL. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS Pathog. 5: e1000586 (2009). *

• Alvarez E, Moga E, Barquinero J, Sierra J, Briones J. Dendritic and tumor cell fusions transduced with adenovirus encoding CD40L eradicate B-cell lymphoma and induce a Th17-type response. Gene Ther. Dec 14 [Epub ahead of print] (2009).

• Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE. T(H)17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13: 711-718 (2007). *

• Ambalavanan N, Carlo WA, D'Angio CT, McDonald SA, Das A, Schendel D, Thorsen P, Higgins RD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123: 1132-1141 (2009). *

• Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone 44: 1143-1150 (2009). *

• Amlong CA, Nardelli DT, Peterson SH, Warner TF, Callister SM, Schell RF. Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice. Clin. Vaccine Immunol. 13: 289-296 (2006). *

• Anderson CF, Stumhofer JS, Hunter CA, Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J. Immunol. 183: 4619-4627 (2009).

• Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 372: 1107-1119 (2008). *

• Andersson A, Isaksson M, Wefer J, Norling A, Flores-Morales A, Rorsman F, Kampe O, Harris RA, Lobell A. Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. PLoS ONE 3: e3682 (2008). *

• Andersson H, Bohn SK, Raastad T, Paulsen G, Blomhoff R, Kadi F. Differences in the inflammatory plasma cytokine response following two elite female soccer games separated by a 72-h recovery. Scand. J. Med. Sci. Sports Sep 17 [Epub ahead of print] (2009).

• Andoh A, Fujino S, Bamba S, Araki Y, Okuno T, Bamba T, Fujiyama Y. IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J. Immunol. 169: 1683-1687 (2002). *

• Andoh A, Hata K, Araki Y, Fujiyama Y, Bamba T. Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. Int. J. Mol. Med. 10: 631-634 (2002).

• Andoh A, Ogawa A, Bamba S, Fujiyama Y. Interaction between interleukin-17-producing CD4(+) T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation? J. Gastroenterol. 42 Suppl. 17: 29-33 (2007). *

• Andoh A, Shioya M, Nishida A, Bamba S, Tsujikawa T, Kim-Mitsuyama S, Fujiyama Y. Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease. J. Immunol. 183: 687-695 (2009).

• Andoh A, Takaya H, Makino J, Sato H, Bamba S, Araki Y, Hata K, Shimada M, Okuno T, Fujiyama Y, Bamba T. Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. Clin. Exp. Immunol. 125: 56-63 (2001). *

• Andoh A, Yasui H, Inatomi O, Zhang Z, Deguchi Y, Hata K, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y. Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts. J. Gastroenterol. 40: 802-810 (2005). *

• Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129: 969-984 (2005). *

• Andre S, Tough DF, Lacroix-Desmazes S, Kaveri SV, Bayry J. Surveillance of antigen-presenting cells by CD4+CD25+ regulatory T cells in autoimmunity. Immunopathogenesis and therapeutic implications. Am. J. Pathol. 174: 1575-1587 (2009). *

• Andreakos E, Rauchhaus U, Stavropoulos A, Endert G, Wendisch V, Benahmed AS, Giaglis S, Karras J, Lee S, Gaus H, Bennett CF, Williams RO, Sideras P, Panzner S. Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis. Arthritis Rheum. 60: 994-1005 (2009). *

• Andreasen C, Powell DA, Carbonetti NH. Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice. PLoS One 4: e7079 (2009). *

• Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C. Regulation of IL-9 expression by IL-25 signaling. Nat. Immunol. Feb 14 [Epub ahead of print] (2010). *

• Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J. Exp. Med. 204: 1509-1517 (2007). *

• Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Type 17 T helper cells - origins, features and possible roles in rheumatic disease. Nat. Rev. Rheumatol. 5: 325-331 (2009).

• Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Human Th17 cells: are they different from murine Th17 cells? Eur. J. Immunol. 39: 637-640 (2009). *

• Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Filì L, Ferri S, Frosali F, Giudici F, Romagnani P, Parronchi P, Tonelli F, Maggi E, Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204: 1849-1861 (2007). *

• Annunziato F, Romagnani S. Heterogeneity of human effector CD4+ T cells. Arthritis Res. Ther. 11: 257 (2009).

• Anthoni M, Fyhrquist N, Lehtimaki S, Alenius H, Wolff H, Lauerma A. Smad3 regulates dermal cytokine and chemokine expression and specific antibody production in murine responses to a respiratory chemical sensitizer. Int. Arch. Allergy Immunol. 151: 155-167 (2009).

• Anthoni M, Fyhrquist-Vanni N, Wolff H, Alenius H, Lauerma A. Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity. Br. J. Dermatol. 159: 546-554 (2008). *

• Antonysamy MA, Fanslow WC, Fu F, Li W, Qian S, Troutt AB, Thomson AW. Evidence for a role of IL-17 in alloimmunity: a novel IL-17 antagonist promotes heart graft survival. Transplant. Proc. 31: 93 (1999).

• Antonysamy MA, Fanslow WC, Fu F, Li W, Qian S, Troutt AB, Thomson AW. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. J. Immunol. 162: 577-584 (1999). *

• Arababadi MK, Nosratabadi R, Hassanshahi G, Yaghini N, Pooladvand V, Shamsizadeh A, Hakimi H, Derakhshan R. Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases? Diabetes Res. Clin. Pract. Oct 27 [Epub ahead of print] (2009).

• Aranami T, Yamamura T. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 57: 115-120 (2008). *

• Arican O, Aral M, Sasmaz S, Ciragil P. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm. 2005: 273-279 (2005). *

• Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, Hirashima M. Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation. Eur. J. Immunol. Nov 9 [Epub ahead of print] (2009). *

• Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Nakamura M, Yoshioka D, Arima Y, Okubo M, Hirata I, Nakano H. The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J. Clin. Immunol. 28: 44-49 (2008). *

• Armstrong-James DP, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TR, Bignell E, Haynes K. Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J. Infect. Dis. 200: 1341-1351 (2009). *

• Asarch A, Barak O, Loo DS, Gottlieb AB. Th17 cells: a new therapeutic target in inflammatory dermatoses. J. Dermatolog. Treat. 19: 318-326 (2008). *

• Ashkar AA, Reid S, Verdu EF, Zhang K, Coombes BK. Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues. Infect. Immun. 77: 214-222 (2009). *

• Asquith DL, McInnes IB. Emerging cytokine targets in rheumatoid arthritis. Curr. Opin. Rheumatol. 19: 246-251 (2007). *

• Atalar K, Afzali B, Lord G, Lombardi G. Relative roles of Th1 and Th17 effector cells in allograft rejection. Curr. Opin. Organ Transplant. 14: 23-29 (2009).

• Atzeni F, Sarzi-Puttini P. Anti-cytokine antibodies for rheumatic diseases. Curr. Opin. Investig. Drugs 10: 1204-1211 (2009).

• Auci D, Kaler L, Subramanian S, Huang Y, Frincke J, Reading C, Offner H. A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory T cells. Ann. N. Y. Acad. Sci. 1110: 630-640 (2007). *

• Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14: 275-281 (2008). *

• Aujla SJ, Dubin PJ, Kolls JK. Th17 cells and mucosal host defense. Semin. Immunol. 19: 377-382 (2007). *

• Aujla SJ, Dubin PJ, Kolls JK. Interleukin-17 in pulmonary host defense. Exp. Lung Res. 33: 507-518 (2007).

• Awane M, Andres PG, Li DJ, Reinecker HC. NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J. Immunol. 162: 5337-5344 (1999). *

• Awasthi A, Kuchroo VK. Th17 cells: from precursors to players in inflammation and infection. Int. Immunol. 21: 489-498 (2009).

• Awasthi A, Kuchroo VK. IL-17A directly inhibits T(H)1 cells and thereby suppresses development of intestinal inflammation. Nat. Immunol. 10: 568-570 (2009). *

• Awasthi A, Murugaiyan G, Kuchroo VK. Interplay between effector Th17 and regulatory T cells. J. Clin. Immunol. 28: 660-670 (2008). *

• Awasthi A, Riol-Blanco L, Jager A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J. Immunol. 182: 5904-5908 (2009).

• Axtell RC, Xu L, Barnum SR, Raman C. CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J. Immunol. 177: 8542-8549 (2006). *

• Ayyoub M, Deknuydt F, Raimbaud I, Dousset C, Leveque L, Bioley G, Valmori D. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORgammat. Proc. Natl. Acad. Sci. U.S.A. 106: 8635-8640 (2009). *

• Baba N, Rubio M, Sarfati M. Interplay between CD45RA+ regulatory T cells and TNF-alpha in the regulation of human Th17 differentiation. Int. Immunol. Feb 24 [Epub ahead of print] (2010).

• Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M. Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J. Leukoc. Biol. 84: 468-476 (2008). *

• Baban B, Chandler PR, Sharma MD, Pihkala J, Koni PA, Munn DH, Mellor AL. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J. Immunol. 183: 2475-2483 (2009).

• Babu S, Bhat SQ, Kumar NP, Jayantasri S, Rukmani S, Kumaran P, Gopi PG, Kolappan C, Kumaraswami V, Nutman TB. Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1. J. Infect. Dis. 200: 288-298 (2009). *

• Babu S, Bhat SQ, Kumar NP, Kumaraswami V, Nutman TB. Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results. J. Infect. Dis. 201: 20-31 (2010). *

• Babu S, Bhat SQ, Pavan Kumar N, Lipira AB, Kumar S, Karthik C, Kumaraswami V, Nutman TB. Filarial lymphedema is characterized by antigen-specific Th1 and Th17 proinflammatory responses and a lack of regulatory T cells. PLoS Negl. Trop. Dis. 3: e420 (2009). *

• Bacellar O, Faria D, Nascimento M, Cardoso TM, Gollob KJ, Dutra WO, Scott P, Carvalho EM. Interleukin 17 production among patients with American cutaneous leishmaniasis. J. Infect. Dis. 200: 75-78 (2009). *

• Backdahl L, Guo JP, Jagodic M, Becanovic K, Ding B, Olsson T, Lorentzen JC. Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case control association data. Ann. Rheum. Dis. 68: 1925-1932 (2009). *

• Badot V, Galant C, Nzeusseu Toukap A, Theate I, Maudoux AL, Van den Eynde BJ, Durez P, Houssiau FA, Lauwerys BR. Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis. Arthritis Res. Ther. 11: R57 (2009). *

• Badoual C, Bouchaud G, Agueznay Nel H, Mortier E, Hans S, Gey A, Fernani F, Peyrard S, Puig PL, Bruneval P, Sastre X, Plet A, Garrigue-Antar L, Quintin-Colonna F, Fridman WH, Brasnu D, Jacques Y, Tartour E. The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer. Cancer Res. 68: 3907-3914 (2008). *

• Baggi F, Ubiali F, Nava S, Nessi V, Andreetta F, Rigamonti A, Maggi L, Mantegazza R, Antozzi C. Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients. J. Neuroimmunol. 201-202: 104-110 (2008).

• Bai A, Lu N, Guo Y, Liu Z, Chen J, Peng Z. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J. Leukoc. Biol. 86: 959-969 (2009). *

• Bai B, Yamamoto K, Sato H, Sugiura H, Tanaka T. Complex regulation of S100A8 by IL-17, dexamethasone, IL-4 and IL-13 in HaCat cells (human keratinocyte cell line). J. Dermatol. Sci. 47: 259-262 (2007).

• Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J. Immunol. 183: 5886-5895 (2009). *

• Bai L, Lennon DP, Eaton V, Maier K, Caplan AI, Miller SD, Miller RH. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 57: 1192-1203 (2009).

• Bai Y, Liu R, Huang D, La Cava A, Tang YY, Iwakura Y, Campagnolo DI, Vollmer TL, Ransohoff RM, Shi FD. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur. J. Immunol. 38: 1877-1888 (2008). *

• Bailey SL, Schreiner B, McMahon EJ, Miller SD. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4(+) T(H)-17 cells in relapsing EAE. Nat. Immunol. 8: 172-180 (2007). *

• Bailey-Bucktrout SL, Caulkins SC, Goings G, Fischer JA, Dzionek A, Miller SD. Cutting edge: central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. J. Immunol. 180: 6457-6461 (2008). *

• Ballantyne SJ, Barlow JL, Jolin HE, Nath P, Williams AS, Chung KF, Sturton G, Wong SH, McKenzie AN. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol. 120: 1324-1331 (2007). *

• Banerjee S, Savant V, Scott RA, Curnow SJ, Wallace GR, Murray PI. Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders. Invest. Ophthalmol. Vis. Sci. 48: 2203-2207 (2007). *

• Banus S, Stenger RM, Gremmer ER, Dormans JA, Mooi FR, Kimman TG, Vandebriel RJ. The role of Toll-like receptor-4 in pertussis vaccine-induced immunity. BMC Immunol. 9: 21 (2008). *

• Baquir B, Lin L, Ibrahim AS, Fu Y, Avanesian V, Tu A, Edwards Jr J, Spellberg B. Immunological reactivity of blood from healthy humans to the rAls3p-N vaccine protein. J. Infect. Dis. Dec 29 [Epub ahead of print] (2009). *

• Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40: 955-962 (2008). *

• Bas S, Neff L, Viatte S, Vuillet M, Spenato U, Guerne PA, Michel M, Tiercy JM, Butrimiene I, Gabay C. Relationship between gamma-interferon and interleukin-17 in Chlamydia trachomatis reactive arthritis. Clin. Exp. Rheumatol. 27: 885-886 (2009).

• Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB. The role of helper and regulatory T cells in the pathogenesis of vitiligo. J. Am. Acad. Dermatol. 60: 256-260 (2009).

• Basso AS, Cheroutre H, Mucida D. More stories on Th17 cells. Cell Res. 19: 399-411 (2009).

• Bastian D, Tamburstuen MV, Lyngstadaas SP, Reikeras O. Systemic and local cytokine kinetics after total hip replacement surgery. Eur. Surg. Res. 41: 334-340 (2008).

• Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7: 929-936 (2006). *

• Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and T(H)-17 cells. Nat. Immunol. 10: 167-175 (2009). *

• Bazzone LE, Smith PM, Rutitzky LI, Shainheit MG, Urban JF, Setiawan T, Blum AM, Weinstock JV, Stadecker MJ. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis. Infect. Immun. 76: 5164-5172 (2008). *

• Beaumier CM, Harris LD, Goldstein S, Klatt NR, Whitted S, McGinty J, Apetrei C, Pandrea I, Hirsch VM, Brenchley JM. CD4 downregulation by memory CD4(+) T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. Nat. Med. 15: 879-885 (2009). *

• Becker H, Pavenstaedt H, Willeke P. Emerging treatment strategies and potential therapeutic targets in primary Sjogren's syndrome. Inflamm. Allergy Drug Targets Sep 1 [Epub ahead of print] (2009).

• Begum-Haque S, Sharma A, Kasper IR, Foureau DM, Mielcarz DW, Haque A, Kasper LH. Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 204: 58-65 (2008).

• Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV. TGF-beta regulates T-cell neurokinin-1 receptor internalization and function. Proc. Natl. Acad. Sci. U.S.A. Feb 16 [Epub ahead of print] (2010). *

• Beklen A, Ainola M, Hukkanen M, Gurgan C, Sorsa T, Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J. Dent. Res. 86: 347-351 (2007).

• Beklen A, Sorsa T, Konttinen YT. Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17. Oral Microbiol. Immunol. 24: 38-42 (2009).

• Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. U.S.A. 106: 7119-7124 (2009). *

• Benatar T, Cao MY, Lee Y, Lightfoot J, Feng N, Gu X, Lee V, Jin H, Wang M, Wright JA, Young AH. IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo. Cancer Immunol. Immunother. Dec 14 [Epub ahead of print] (2009).

• Benderdour M, Tardif G, Pelletier JP, Di Battista JA, Reboul P, Ranger P, Martel-Pelletier J. Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta. J. Rheumatol. 29: 1262-1272 (2002). *

• Bending D, De La Pena H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B, Cooke A. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J. Clin. Invest. 119: 565-572 (2009). *

• Benghiat FS, Charbonnier LM, Vokaer B, Wilde VD, Moine AL. Interleukin 17-producing T helper cells in alloimmunity. Transplant. Rev. (Orlando) 23: 11-18 (2009).

• Benghiat FS, Craciun L, De Wilde V, Dernies T, Kubjak C, Lhomme F, Goldman M, Le Moine A. IL-17 production elicited by allo-major histocompatibility complex class II recognition depends on CD25posCD4pos T cells. Transplantation 85: 943-949 (2008).

• Beran O, Lawrence DA, Andersen N, Dzupova O, Kalmusova J, Musilek M, Holub M. Sequential analysis of biomarkers in cerebrospinal fluid and serum during invasive meningococcal disease. Eur. J. Clin. Microbiol. Infect. Dis. 28: 793-799 (2009).

• Berg LJ. Strength of T cell receptor signaling strikes again. Immunity 31: 529-531 (2009). *

• Berg WB. Lessons from animal models of arthritis over the past decade. Arthritis Res. Ther. 11: 250 (2009).

• Bergman R, Ramon M, Wildbaum G, Avitan-Hersh E, Mayer E, Shemer A, Karin N. Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha. J. Dermatol. Sci. 56: 163-167 (2009).

• Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17 producing human peripheral regulatory T cells retain suppressive function. Blood 113: 4240-4249 (2009). *

• Bermejo-Martin JF, Ortiz de Lejarazu R, Pumarola T, Rello J, Almansa R, Ramirez P, Martin-Loeches I, Varillas D, Gallegos MC, Seron C, Micheloud D, Gomez JM, Tenorio-Abreu A, Ramos MJ, Molina ML, Huidobro S, Sanchez E, Gordon M, Fernandez V, et al. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit. Care 13: R201 (2009). *

• Bertolino P. Interleukin-22, interleukin-17, and other cytokines: a wall is coming down. Hepatology 47: 345-348 (2008). *

• Bessis N, Boissier MC. Novel pro-inflammatory interleukins: potential therapeutic targets in rheumatoid arthritis. Joint Bone Spine 68: 477-481 (2001).

• Bettelli E, Kuchroo VK. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J. Exp. Med. 201: 169-171 (2005). *

• Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8: 345-350 (2007). *

• Bezerra MC, Carvalho JF, Prokopowitsch AS, Pereira RM. RANK, RANKL and osteoprotegerin in arthritic bone loss. Braz. J. Med. Biol. Res. 38: 161-170 (2005). *

• Bi Y, Liu G, Yang R. Th17 cell induction and immune regulatory effects. J. Cell. Physiol. 211: 273-278 (2007). *

• Bikker A, van Woerkom J, Kruize A, Wenting-van Wijk M, de Jager W, Bijlsma J, Lafeber F, van Roon J. Increased expression of Interleukin-7 in labial salivary glands of patients with primary Sjogren's syndrome correlates with increased inflammation. Arthritis Rheum. Jan 13 [Epub ahead of print] (2010). *

• Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, Oo YH, Kollnberger S, Bowness P, Drognitz O, Adams DH, et al. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc. Natl. Acad. Sci. U.S.A. Jan 28 [Epub ahead of print] (2010). *

• Bin C, Zhirong Z, Xiaoqin W, Minhu C, Mei L, Xiang G, Baili C, Pinjin H. Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population. J. Genet. 88: 191-196 (2009). *

• Bird L. Human TH17 cells take centre stage. Nat. Rev. Immunol. 7: 413 (2007). *

• Blaho VA, Buczynski MW, Dennis EA, Brown CR. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. J. Immunol. 183: 5644-5653 (2009).

• Blaschitz C, Raffatellu M. Th17 cytokines and the gut mucosal barrier. J. Clin. Immunol. Feb 2 [Epub ahead of print] (2010). *

• Blasko E, Haskell CA, Leung S, Gualtieri G, Halks-Miller M, Mahmoudi M, Dennis MK, Prossnitz ER, Karpus WJ, Horuk R. Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J. Neuroimmunol. 214: 67-77 (2009).

• Blauvelt A. New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-B1. Exp. Rev. Dermatol. 2: 69-78 (2007). *

• Blewis ME, Lao BJ, Schumacher BL, Bugbee WD, Sah RL, Firestein GS. Interactive cytokine regulation of synoviocyte lubricant secretion. Tissue Eng. Part A. Nov 12 [Epub ahead of print] (2009).

• Bluestone JA. A balanced attack. The Scientist May, 2007 (http://www.the-scientist.com/2007/05/01/s32/1/ ) (2007).

• Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, Haynes LD, Braun RK, Hayney MS, Munoz Del Rio A, Meyer K, Greenspan DS, Torrealba J, Heidler KM, Cummings OW, Iwata T, Brand D, Presson R, Burlingham WJ, Wilkes DS. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am. J. Respir. Crit. Care Med. 177: 660-668 (2008). *

• Bodhankar S, Woolard MD, Sun X, Simecka JW. NK cells interfere with the generation of resistance against Mycoplasma respiratory infection following nasal-pulmonary immunization. J. Immunol. 183: 2622-2631 (2009).

• Boehm BO, Rosinger S, Sauer G, Manfras BJ, Palesch D, Schiekofer S, Kalbacher H, Burster T. Protease-resistant human GAD-derived altered peptide ligands decrease TNF-alpha and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus. Mol. Immunol. 46: 2576-2584 (2009). *

• Bogaert D, Weinberger D, Thompson C, Lipsitch M, Malley R. Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. Infect. Immun. 77: 1613-1622 (2009). *

• Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int. Immunol. 21: 511-522 (2009).

• Bommireddy R, Doetschman T. TGFbeta1 and T(reg) cells: alliance for tolerance. Trends Mol. Med. 13: 492-501 (2007). *

• Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med. 206: 535-548 (2009). *

• Boniface K, Blom B, Liu YJ, de Waal Malefyt R. From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol. Rev. 226: 132-146 (2008). *

• Boniface K, Diveu C, Morel F, Pedretti N, Froger J, Ravon E, Garcia M, Venereau E, Preisser L, Guignouard E, Guillet G, Dagregorio G, Pene J, Moles JP, Yssel H, Chevalier S, Bernard FX, Gascan H, Lecron JC. Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J. Immunol. 178: 4615-4622 (2007). *

• Bonneville M. gammadelta T cell selection: is anyone useless? Immunity 29: 3-5 (2008). *

• Bonville CA, Bennett NJ, Percopo CM, Branigan PJ, Del Vecchio AM, Rosenberg HF, Domachowske JB. Diminished inflammatory responses to natural pneumovirus infection among older mice. Virology 368: 182-190 (2007). *

• Boomsma CM, Kavelaars A, Eijkemans MJ, Amarouchi K, Teklenburg G, Gutknecht D, Fauser BJ, Heijnen CJ, Macklon NS. Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity. Reprod. Biomed. Online 18: 85-94 (2009).

• Boomsma CM, Kavelaars A, Eijkemans MJ, Lentjes EG, Fauser BC, Heijnen CJ, Macklon NS. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum. Reprod. 24: 1427-1435 (2009).

• Bordon Y, Hansell CA, Sester DP, Clarke M, Mowat AM, Nibbs RJ. The atypical chemokine receptor d6 contributes to the development of experimental colitis. J. Immunol. 182: 5032-5040 (2009).

• Botero JE, Contreras A, Parra B. Profiling of inflammatory cytokines produced by gingival fibroblasts after human cytomegalovirus infection. Oral Microbiol. Immunol. 23: 291-298 (2008).

• Botoi G, Andercou A. Interleukin 17 - prognostic marker of severe acute pancreatitis. Chirurgia (Bucur.) 104: 431-438 (2009).

• Boudousquie C, Pellaton C, Barbier N, Spertini F. CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma. Clin. Exp. Allergy 39: 1415-1426 (2009). *

• Bouguermouh S, Fortin G, Baba N, Rubio M, Sarfati M. CD28 co-stimulation down regulates Th17 development. PLoS ONE 4: e5087 (2009). *

• Bowen JL, Olson JK. Innate immune CD11b+Gr-1+ cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating disease. J. Immunol. 183: 6971-6980 (2009).

• Bowman EP, Chackerian AA, Cua DJ. Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr. Opin. Infect. Dis. 19: 245-252 (2006).

• Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC, Bozza PT. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit. Care 11: R49 (2007). *

• Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J. Immunol. 183: 4432-4439 (2009).

• Brand S. Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease. Gut 58: 1152-1167 (2009).

• Braun RK, Ferrick C, Neubauer P, Sjoding M, Sterner-Kock A, Kock M, Putney L, Ferrick DA, Hyde DM, Love RB. IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Inflammation 31: 167-179 (2008). *

• Braun RK, Molitor-Dart M, Wigfield C, Xiang Z, Fain SB, Jankowska-Gan E, Seroogy CM, Burlingham WJ, Wilkes DS, Brand DD, Torrealba J, Love RB. Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection. Transplantation 88: 1341-1348 (2009).

• Brekke OL, Christiansen D, Fure H, Pharo A, Fung M, Riesenfeld J, Mollnes TE. Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood. Mol. Immunol. 45: 3804-3813 (2008). *

• Brennan F, Beech J. Update on cytokines in rheumatoid arthritis. Curr. Opin. Rheumatol. 19: 296-301 (2007).

• Brentano F, Ospelt C, Stanczyk J, Gay RE, Gay S, Kyburz D. Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis. Ann. Rheum. Dis. 68: 143-150 (2009).

• Brereton CF, Sutton CE, Lalor SJ, Lavelle EC, Mills KH. Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. J. Immunol. 183: 1715-1723 (2009).

• Brewster JA, Orsi NM, Gopichandran N, Ekbote UV, Cadogan E, Walker JJ. Host inflammatory response profiling in preeclampsia using an in vitro whole blood stimulation model. Hypertens. Pregnancy 27: 1-16 (2008).

• Brinster C, Shevach EM. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J. Leukoc. Biol. 84: 480-487 (2008). *

• Brodsky M, Hirsh S, Albeck M, Sredni B. Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury. J. Hepatol. 51: 491-503 (2009).

• Brown KD, Claudio E, Siebenlist U. The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res. Ther. 10: 212 (2008). *

• Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J. Immunol. 183: 5494-5501 (2009).

• Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 132: 3329-3341 (2009).

• Brunn A, Utermohlen O, Carstov M, Sanchez Ruiz M, Miletic H, Schluter D, Deckert M. CD4 T cells mediate axonal damage and spinal cord motor neuron apoptosis in murine P0106-125-induced experimental autoimmune neuritis. Am. J. Pathol. 173: 93-105 (2008). *

• Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8: 958-966 (2007). *

• Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse HC 3rd, Leonard WJ, Roopenian DC. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc. Natl. Acad. Sci. U.S.A. 106: 1518-1523 (2009). *

• Bucher C, Jasperson L, Vogtenhuber C, Goren E, Munger M, Panoskaltsis-Mortari A, Sivakumar P, Blazar BR. IL-21 blockade reduces graft-versus-host-disease mortality by supporting inducible T regulatory cell generation. Blood 114: 5375-5384 (2009). *

• Bugeon L, Gardner LM, Rose A, Gentle M, Dallman MJ. Cutting edge: Notch signaling induces a distinct cytokine profile in dendritic cells that supports T cell-mediated regulation and IL-2-dependent IL-17 production. J. Immunol. 181: 8189-8193 (2008). *

• Bullard DC, Hu X, Adams JE, Schoeb TR, Barnum SR. p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis. Am. J. Pathol. 170: 2001-2008 (2007). *

• Bullens DM. Measuring T cell cytokines in allergic upper and lower airway inflammation: can we move to the clinic? Inflamm. Allergy Drug Targets 6: 81-90 (2007).

• Bullens DM, Truyen E, Coteur L, Dilissen E, Hellings PW, Dupont LJ, Ceuppens JL. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir. Res. 7: 135 (2006). *

• Buning C, Schmidt HH, Molnar T, DE Jong DJ, Fiedler T, Buhner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Drenth JP, Landt O, Nickel R, Buttner J, Lochs H, Witt H. Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. Aliment. Pharmacol. Ther. 26: 1025-1033 (2007). *

• Buning J, von Smolinski D, Tafazzoli K, Zimmer KP, Strobel S, Apostolaki M, Kollias G, Heath JK, Ludwig D, Gebert A. Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II-restricted antigen processing and origin of exosomes. Immunology 125: 510-521 (2008). *

• Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect. Immun. 71: 3437-3442 (2003). *

• Burgler S, Ouaked N, Bassin C, Basinski TM, Mantel PY, Siegmund K, Meyer N, Akdis CA, Schmidt-Weber CB. Differentiation and functional analysis of human T(H)17 cells. J. Allergy Clin. Immunol. 123: 588-595, 595.e1-e7 (2009).

• Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J. Clin. Invest. 117: 3498-3506 (2007). *

• Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J. Immunol. 181: 3906-3914 (2008). *

• Bush KA, Farmer KM, Walker JS, Kirkham BW. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 46: 802-805 (2002). *

• Cagnin S, Biscuola M, Patuzzo C, Trabetti E, Pasquali A, Laveder P, Faggian G, Iafrancesco M, Mazzucco A, Pignatti PF, Lanfranchi G. Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries. BMC Genomics 10: 13 (2009). *

• Cai L, Yin JP, Starovasnik MA, Hogue DA, Hillan KJ, Mort JS, Filvaroff EH. Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 16: 10-21 (2001).

• Caldwell CC, Okaya T, Martignoni A, Husted T, Schuster R, Lentsch AB. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G969-G976 (2005). *

• Camelo S, Lajavardi L, Bochot A, Goldenberg B, Naud MC, Brunel N, Lescure B, Klein C, Fattal E, Behar-Cohen F, de Kozak Y. Protective effect of intravitreal injection of vasoactive intestinal peptide (VIP)-loaded liposomes on experimental autoimmune uveoretinitis. J. Ocul. Pharmacol. Ther. 25: 9-21 (2009).

• Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J. AIDS progression is associated with the emergence of IL-17-producing cells early after Simian immunodeficiency virus infection. J. Immunol. 184: 984-992 (2010).

• Canonigo-Balancio AJ, Fos C, Prod'homme T, Becart S, Altman A. SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. J. Immunol. 183: 7259-7267 (2009).

• Cao Y, Doodes PD, Glant TT, Finnegan A. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 180: 922-930 (2008). *

• Capocasale RJ, Makropoulos DA, Achuthanandam R, Stowell N, Quinn J, Rafferty PA, O'Brien J, Emmell E, Bugelski PJ. Myelodysplasia and anemia of chronic disease in human tumor necrosis factor-alpha transgenic mice. Cytometry A. 73: 148-159 (2008).

• Caprioli F, Pallone F, Monteleone G. Th17 immune response in IBD: a new pathogenic mechanism. Journal of Crohn's and Colitis 2: 291-295 (2008).

• Caproni M, Antiga E, Melani L, Volpi W, Del Bianco E, Fabbri P. Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial. J. Clin. Immunol. 29: 210-214 (2009). *

• Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Junior WM, Rossi MA, Silva JS. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol. Immunol. 24: 1-6 (2009). *

• Carter J, Zhang J, Dang TL, Hasegawa H, Cheng JD, Gianan I, O'Neill JW, Wolfson M, Siu S, Qu S, Meininger D, Budelsky AL, Kim H, Delaney J, Mehlin C. Fusion partners can increase the expression of recombinant interleukins via transient transfection in 2936E cells. Protein Sci. Dec 14 [Epub ahead of print] (2009). *

• Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, Benoit S, Ireland G, Luxenberg D, Askew GR, Milarski KL, Groves C, Brown T, Carito BA, Percival K, Carreno BM, Collins M, Marusic S. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 182: 124-134 (2007).

• Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M, Andrei F, Fantini MC, Macdonald TT, Pallone F, Monteleone G. IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur. J. Immunol. 38: 470-478 (2008). *

• Caruso R, Pallone F, Monteleone G. Emerging role of IL-23/IL-17 axis in H. pylori-associated pathology. World J. Gastroenterol. 13: 5547-5551 (2007). *

• Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, Macdonald TT, Monteleone G. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via a p38 Map kinase-dependent induction of SOCS-3. Blood 113: 3512-3519 (2009). *

• Carvalho A, Cunha C, Di Ianni M, Pitzurra L, Aloisi T, Falzetti F, Carotti A, Bistoni F, Aversa F, Romani L. Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation. Bone Marrow Transplant. Feb 22 [Epub ahead of print] (2010).

• Carvalho B, Clark DJ, Angst MS. Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery. J. Pain 9: 650-657 (2008).

• Carvalho B, Clark DJ, Yeomans D, Angst MS. Collecting and measuring nociceptive and inflammatory mediators in surgical wounds. J. Vis. Exp. 20: pii: 962 (2008). *

• Caspi R. Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells. Immunol. Res. 42: 41-50 (2008). *

• Castellanos-Rubio A, Santin I, Irastorza I, Castano L, Carlos Vitoria J, Ramon Bilbao J. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 42: 69-73 (2009).

• Cencioni MT, Chiurchiu V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, Maccarrone M. Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB(2) receptors. PLoS One 5: e8688 (2010). *

• Chabane N, Zayed N, Afif H, Mfuna-Endam L, Benderdour M, Boileau C, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H. Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E(2) production in human chondrocytes. Osteoarthritis Cartilage 16: 1267-1274 (2008).

• Chabaud M, Lubberts E, Joosten L, van Den Berg W, Miossec P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res. 3: 168-177 (2001). *

• Chabaud M, Miossec P. The combination of tumor necrosis factor alpha blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model. Arthritis Rheum. 44: 1293-1303 (2001). *

• Chabaud M, Page G, Miossec P. Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines. J. Immunol. 167: 6015-6020 (2001). *

• Chackerian AA, Chen SJ, Brodie SJ, Mattson JD, McClanahan TK, Kastelein RA, Bowman EP. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect. Immun. 74: 6092-6099 (2006). *

• Chai LY, van de Veerdonk F, Marijnissen RJ, Cheng SC, Khoo AL, Hectors M, Lagrou K, Vonk AG, Maertens J, Joosten LA, Kullberg BJ, Netea MG. Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity. Immunology Dec 14 [Epub ahead of print] (2009). *

• Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 20: 334-345 (2009).

• Chan J, Ban EJ, Chun KH, Wang S, Backstrom BT, Bernard CC, Toh BH, Alderuccio F. Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease. J. Immunol. 181: 7571-7580 (2008). *

• Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J. Exp. Med. 203: 2577-2587 (2006). *

• Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, Mak TW, Clifton MC, Strong RK, Ray P, Kolls JK. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J. Immunol. 182: 4947-4956 (2009).

• Chandran SS, Verhoeven D, Teijaro JR, Fenton MJ, Farber DL. TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses. J. Immunol. 183: 7832-7841 (2009).

• Chang BY, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan DG, Grossbard EB, Pine PR, Bullard DC. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J. Immunol. 183: 2183-2192 (2009).

• Chang H, Hanawa H, Yoshida T, Hayashi M, Liu H, Ding L, Otaki K, Hao K, Yoshida K, Kato K, Toba K, Kodama M, Maruyama H, Miyazaki J, Aizawa Y. Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer. Circ. J. 72: 813-819 (2008). *

• Chang SH, Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 17: 435-440 (2007). *

• Chang SH, Park H, Dong C. Act1 adaptor protein is an immediate and essential signaling component of IL-17 receptor. J. Biol. Chem. 281: 35603-35607 (2006). *

• Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson RG, Kollias G, Smyth JF, Balkwill FR, Hagemann T. The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J. Clin. Invest. 119: 3011-3023 (2009). *

• Chaudhary N, Staab JF, Marr KA. Healthy human T-cell responses to Aspergillus fumigatus antigens. PLoS One 5: e9036 (2010). *

• Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J. Immunol. 182: 1247-1252 (2009).

• Chen B, Hu J, Liao L, Sun Z, Han Q, Song Z, Zhao RC. Flk-1(+) mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6. Clin. Exp. Immunol. Dec 14 [Epub ahead of print] (2009). *

• Chen B, Zeng Z, Hou J, Chen M, Gao X, Hu P. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand. J. Gastroenterol. 44: 720-726 (2009). *

• Chen H, Qin J, Wei P, Zhang J, Li Q, Fu L, Li S, Ma C, Cong B. Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells. Prostaglandins Leukot. Essent. Fatty Acids 80: 195-200 (2009). *

• Chen H, Wang W, Xie H, Xu X, Wu J, Jiang Z, Zhang M, Zhou L, Zheng S. A pathogenic role of IL-17 at the early stage of corneal allograft rejection. Transpl. Immunol. 21: 155-161 (2009).

• Chen K, Wei Y, Sharp GC, Braley-Mullen H. Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. J. Leukoc. Biol. 81: 306-314 (2007). *

• Chen L, Ahmed E, Wang T, Wang Y, Ochando J, Chong AS, Alegre ML. TLR signals promote IL-6/IL-17-dependent transplant rejection. J. Immunol. 182: 6217-6225 (2009).

• Chen L, Yang P, Zhou H, He H, Ren X, Chi W, Wang L, Kijlstra A. Decreased frequency and diminished function of CD4+CD25high regulatory T cells are associated with active uveitis in patients with Vogt-Koyanagi-Harada syndrome. Invest. Ophthalmol. Vis. Sci. 49: 3475-3482 (2008). *

• Chen M, Chen G, Nie H, Zhang X, Niu X, Zang YC, Skinner SM, Zhang JZ, Killian JM, Hong J. Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T cells in MS. Eur. J. Immunol. 39: 2525-2536 (2009). *

• Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J. Immunol. 180: 7327-7337 (2008). *

• Chen Q, Yang W, Gupta S, Biswas P, Smith P, Bhagat G, Pernis AB. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 29: 899-911 (2008). *

• Chen SJ, Wang YL, Kao JH, Wu SF, Lo WT, Wu CC, Tao PL, Wang CC, Chang DM, Sytwu HK. Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells. Mol. Immunol. 47: 567-574 (2009). *

• Chen X, Das R, Komorowski R, van Snick J, Uyttenhove C, Drobyski WR. Interleukin 17 is not required for autoimmune-mediated pathological damage during chronic graft versus host disease. Biol. Blood Marrow Transplant. Sep 16 [Epub ahead of print] (2009).

• Chen X, Howard OM, Oppenheim JJ. Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells. J. Immunol. 178: 6123-6129 (2007). *

• Chen X, Wan J, Liu J, Xie W, Diao X, Xu J, Zhu B, Chen Z. Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. Lung Cancer Dec 16 [Epub ahead of print] (2009).

• Chen X, Zhang G, Li Y, Feng X, Wan F, Zhang L, Wang J, Zhang X. Circulating B7-H3(CD276) elevations in cerebrospinal fluid and plasma of children with bacterial meningitis. J. Mol. Neurosci. 37: 86-94 (2009).

• Chen X, Zhang M, Liao M, Graner MW, Wu C, Yang Q, Liu H, Zhou B. Reduced Th17 response in patients with tuberculosis correlate with IL-6R expression on CD4+ T cells. Am. J. Respir. Crit. Care Med. Dec 17 [Epub ahead of print] (2009). *

• Chen X, Zhang M, Zhu X, Deng Q, Liu H, Larmonier N, Graner MW, Zhou B. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. J. Infect. Dis. 200: 399-408 (2009). *

• Chen XQ, Yu YC, Deng HH, Sun JZ, Dai Z, Wu YW, Yang M. Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity. J. Clin. Immunol. Jan 28 [Epub ahead of print] (2010). *

• Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 116: 1317-1326 (2006). *

• Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, Tato C, Yoshimura A, Hennighausen L, O'Shea JJ. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. U.S.A. 103: 8137-8142 (2006). *

• Chen Z, Laurence A, O'Shea JJ. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 19: 400-408 (2007). *

• Chen Z, O'Shea JJ. Th17 cells: a new fate for differentiating helper T cells. Immunol. Res. 41: 87-102 (2008). *

• Chen Z, O'Shea JJ. Regulation of IL-17 production in human lymphocytes. Cytokine 41: 71-78 (2008).

• Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56: 2936-2946 (2007). *

• Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, Yao R, Chen Y, Liao YH. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin. Immunol. 127: 89-97 (2008). *

• Cheung PF, Wong CK, Ip WK, Lam CW. IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation. Allergy 61: 878-885 (2006). *

• Cheung PF, Wong CK, Lam CW. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation. J. Immunol. 180: 5625-5635 (2008). *

• Chi W, Yang P, Li B, Wu C, Jin H, Zhu X, Chen L, Zhou H, Huang X, Kijlstra A. IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J. Allergy Clin. Immunol. 119: 1218-1224 (2007). *

• Chi W, Zhu X, Yang P, Liu X, Lin X, Zhou H, Huang X, Kijlstra A. Upregulated IL-23 and IL-17 in Behcet patients with active uveitis. Invest. Ophthalmol. Vis. Sci. 49: 3058-3064 (2008). *

• Chiang EY, Kolumam GA, Yu X, Francesco M, Ivelja S, Peng I, Gribling P, Shu J, Lee WP, Refino CJ, Balazs M, Paler-Martinez A, Nguyen A, Young J, Barck KH, Carano RA, Ferrando R, Diehl L, Chatterjea D, Grogan JL. Targeted depletion of lymphotoxin-alpha-expressing T(H)1 and T(H)17 cells inhibits autoimmune disease. Nat. Med. 15: 766-773 (2009). *

• Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi 30: 375-382 (2007).

• Chizzolini C, Chicheportiche R, Alvarez M, de Rham C, Roux-Lombard P, Ferrari-Lacraz S, Dayer JM. Prostaglandin E2 (PGE2) synergistically with interleukin-23 (IL-23) favors human Th17 expansion. Blood 112: 3696-3703 (2008). *

• Cho ML, Heo YJ, Park MK, Oh HJ, Park JS, Woo YJ, Ju JH, Park SH, Kim HY, Min JK. Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunol. Lett. 124: 102-110 (2009).

• Cho ML, Ju JH, Kim HR, Oh HJ, Kang CM, Jhun JY, Lee SY, Park MK, Min JK, Park SH, Lee SH, Kim HY. Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol. Lett. 108: 121-128 (2007).

• Cho ML, Ju JH, Kim KW, Moon YM, Lee SY, Min SY, Cho YG, Kim HS, Park KS, Yoon CH, Lee SH, Park SH, Kim HY. Cyclosporine A inhibits IL-15-induced IL-17 production in CD4(+) T cells via down-regulation of PI3K/Akt and NF-kappaB. Immunol. Lett. 108: 88-96 (2007).

• Cho ML, Jung YO, Kim KW, Park MK, Oh HJ, Ju JH, Cho YG, Min JK, Kim SI, Park SH, Kim HY. IL-17 induces the production of IL-16 in rheumatoid arthritis. Exp. Mol. Med. 40: 237-245 (2008). *

• Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, Jin HT, Min SY, Ju JH, Park KS, Cho YG, Yoon CH, Park SH, Sung YC, Kim HY. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J. Immunol. 176: 5652-5661 (2006). *

• Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol. Lett. 105: 159-166 (2006).

• Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY. Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts. Arthritis Rheum. 50: 776-784 (2004). *

• Cho SG, Min SY, Park MJ, Lee KW, Cho YG, Cho ML, Chang HS, Park SH, Lee JW, Min WS, Kim CC, Kim HY. Immunoregulatory effects of allogeneic mixed chimerism induced by nonmyeloablative bone marrow transplantation on chronic inflammatory arthritis and autoimmunity in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 54: 1878-1887 (2006). *

• Choi HM, Oh DH, Bang JS, Yang HI, Yoo MC, Kim KS. Differential effect of IL-1beta and TNF-alpha on the production of IL-6, IL-8 and PGE(2) in fibroblast-like synoviocytes and THP-1 macrophages. Rheumatol. Int. Aug 21 [Epub ahead of print] (2009). *

• Choi J, Ha KH, Byun MS, Min SY, Park MJ, Park HS, Oh HJ, Ju JH, Kim HY, Jue DM. Treatment with N-tosyl-L-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation. Eur. J. Pharmacol. 595: 108-113 (2008).

• Choi JM, Kim SH, Shin JH, Gibson T, Yoon BS, Lee DH, Lee SK, Bothwell AL, Lim JS, Lee SK. Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A. 105: 19875-19880 (2008). *

• Chong BF, Wilson AJ, Gibson HM, Hafner MS, Luo Y, Hedgcock CJ, Wong HK. Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides. Clin. Cancer Res. 14: 646-653 (2008). *

• Chow WL, Lee YK. Free fucose is a danger signal to human intestinal epithelial cells. Br. J. Nutr. 99: 449-454 (2008). *

• Christopher MJ, Link DC. Regulation of neutrophil homeostasis. Curr. Opin. Hematol. 14: 3-8 (2007).

• Chu CQ, Swart D, Alcorn D, Tocker J, Elkon KB. Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum. 56: 1145-1151 (2007). *

• Chung Y, Dong C. Don’t leave home without it: the IL-23 visa to TH-17 cells. Nat. Immunol. 10: 236-238 (2009). *

• Chung Y, Yang X, Chang SH, Ma L, Tian Q, Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16: 902-907 (2006). *

• Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V, Giardina E, Craxi A, Pitzalis C, Triolo G. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum. 60: 955-965 (2009). *

• Cihakova D, Rose NR. Chapter 4. Pathogenesis of myocarditis and dilated cardiomyopathy. Adv. Immunol. 99C: 95-114 (2008).

• Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, Marseglia G, Tosca M. Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy 64: 1375-1378 (2009). *

• Ciprandi G, De Amici M, Negrini S, Marseglia G, Tosca MA. TGF-beta and IL-17 serum levels and specific immunotherapy. Int. Immunopharmacol. 9: 1247-1249 (2009).

• Ciprandi G, Fenoglio D, De Amici M, Quaglini S, Negrini S, Filaci G. Serum IL-17 levels in patients with allergic rhinitis. J. Allergy Clin. Immunol. 122: 650-651.e2 (2008). *

• Ciprandi G, Filaci G, Battaglia F, Fenoglio D. Peripheral Th17 cells in allergic rhinitis: new evidence. Int. Immunopharmacol. Nov 16 [Epub ahead of print] (2009).

• Ciric B, El-Behi M, Cabrera R, Zhang GX, Rostami A. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J. Immunol. 182: 5296-5305 (2009).

• Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J. Immunol. 182: 1617-1630 (2009).

• Cludts I, Meager A, Thorpe R, Wadhwa M. Detection of neutralizing interleukin-17 antibodies in autoimmune polyendocrinopathy syndrome-1 (APS-1) patients using a novel non-cell based electrochemiluminescence assay. Cytokine Jan 27 [Epub ahead of print] (2010).

• Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, Benagiano M, Paccani SR, Sambri V, Del Prete G, Baldari CT, Zanotti G, Montecucco C, D'Elios MM, de Bernard M. Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum. 58: 3609-3617 (2008). *

• Colbert RA, Deodhar AA, Khan MA, Lories RJ, Maksymowych WP, Reveille JD, Ritchlin CT, Rosenbaum JT, Targan SR, Weisman M, Clegg DO. 2007 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). J. Rheumatol. 35: 1398-1402 (2008).

• Cole P. Insights into inflammatory mechanisms and new therapeutic strategies. Drug News Perspect. 21: 573-579 (2008).

• Colic M, Gazivoda D, Vucevic D, Vasilijic S, Rudolf R, Lukic A. Proinflammatory and immunoregulatory mechanisms in periapical lesions. Mol. Immunol. 47: 101-113 (2009). *

• Colic M, Vasilijic S, Gazivoda D, Vucevic D, Marjanovic M, Lukic A. Interleukin-17 plays a role in exacerbation of inflammation within chronic periapical lesions. Eur. J. Oral Sci. 115: 315-320 (2007). *

• Colin EM, Asmawidjaja PS, van Hamburg JP, Mus AM, van Driel M, Hazes JM, van Leeuwen JP, Lubberts E. 1,25-Dihydroxyvitamin D(3) modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum. 62: 132-142 (2009). *

• Colonna M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity 31: 15-23 (2009). *

• Commodaro A, Bombardieri C, Peron J, Saito K, Guedes P, Hamassaki DE, Belfort RN, Rizzo L, Belfort R, Camargo M. p38alpha MAP kinase controls IL-17 synthesis in Vogt-Koyanagi-Harada syndrome and experimental autoimmune uveitis (EAU). Invest. Ophthalmol. Vis. Sci. Feb 17 [Epub ahead of print] (2010).

• Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206: 299-311 (2009). *

• Conti P, Youinou P, Theoharides TC. Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32). Autoimmun. Rev. 6: 131-137 (2007). *

• Cooke A. Th17 cells in inflammatory conditions. Rev. Diabet. Stud. 3: 72-75 (2006). *

• Cooper AM. IL-17 and anti-bacterial immunity: protection versus tissue damage. Eur. J. Immunol. 39: 649-652 (2009). *

• Cooper AM. IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection. Eur. J. Immunol. 37: 2680-2682 (2007). *

• Cooper AM, Khader SA. The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol. Rev. 226: 191-204 (2008). *

• Coquet JM, Chakravarti S, Kyparissoudis K, McNab FW, Pitt LA, McKenzie BS, Berzins SP, Smyth MJ, Godfrey DI. Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc. Natl. Acad. Sci. U.S.A. 105: 11287-11292 (2008). *

• Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180: 7097-7101 (2008). *

• Cornelissen F, Mus AM, Asmawidjaja PS, van Hamburg JP, Tocker J, Lubberts E. Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cells. Arthritis Res. Ther. 11: R194 (2009). *

• Cornelissen F, van Hamburg JP, Lubberts E. The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis. Curr. Opin. Investig. Drugs 10: 452-462 (2009).

• Correale J, Farez M. Monocyte-derived dendritic cells in multiple sclerosis: the effect of bacterial infection. J. Neuroimmunol. 190: 177-189 (2007).

• Correale J, Ysrraelit MC, Gaitan MI. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain 132: 1146-1160 (2009).

• Cortes LM, Avichezer D, Silver PB, Luger D, Mattapallil MJ, Chan CC, Caspi RR. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells. J. Leukoc. Biol. 84: 577-585 (2008). *

• Cortez DM, Feldman MD, Srinivas M, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. Interleukin-17 stimulates MMP1 expression in primary human cardiac fibroblasts via p38 MAPK and ERK1/2-dependent C/EBPbeta, NF-kappaB, and AP-1 activation. Am. J. Physiol. Heart Circ. Physiol. 293: H3356-H3365 (2007). *

• Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 205: 1903-1916 (2008). *

• Costello P, FitzGerald O. Disease mechanisms in psoriasis and psoriatic arthritis. Curr. Rheumatol. Rep. 3: 419-427 (2001).

• Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter JI, Arico M, Delprat C. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat. Med. 14: 81-87 (2008). *

• Cowden JM, Zhang M, Dunford PJ, Thurmond RL. The histamine H(4) receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. J. Invest. Dermatol. Nov 12 [Epub ahead of print] (2009). *

• Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol. 180: 7414-7422 (2008). *

• Crabe S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J. Immunol. 183: 7692-7702 (2009).

• Creed TJ, Lee RW, Newcomb PV, di Mambro AJ, Raju M, Dayan CM. The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone. J. Immunol. 183: 164-171 (2009).

• Crispim JC, Grespan R, Martelli-Palomino G, Rassi DM, Costa RS, Saber LT, Cunha FQ, Donadi EA. Interleukin-17 and kidney allograft outcome. Transplant. Proc. 41: 1562-1564 (2009). *

• Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 181: 8761-8766 (2008). *

• Crispín JC, Tsokos GC. Human TCR-alphabeta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J. Immunol. 183: 4675-4681 (2009).

• Crome SQ, Wang AY, Kang CY, Levings MK. The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4(+) T cells. Eur. J. Immunol. 39: 1480-1493 (2009). *

• Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK. Critical role of IL-17RA in immunopathology of influenza infection. J. Immunol. 183: 5301-5310 (2009).

• Croxford AL, Kurschus FC, Waisman A. Cutting edge: an IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. J. Immunol. 182: 1237-1241 (2009).

• Cruz A, Khader SA, Torrado E, Fraga A, Pearl JE, Pedrosa J, Cooper AM, Castro AG. Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J. Immunol. 177: 1416-1420 (2006). *

• Csernok E, Lamprecht P, Gross WL. Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis. Curr. Opin. Rheumatol. 22: 43-48 (2010).

• Csiszar A, Ungvari Z. Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease. Med. Hypotheses 63: 696-698 (2004).

• Cui Y, Shao H, Lan C, Nian H, O'Brien RL, Born WK, Kaplan HJ, Sun D. Major role of gammadelta T cells in the generation of IL-17+ uveitogenic T cells. J. Immunol. 183: 560-567 (2009).

• Cui Y, Shao H, Sun D, Kaplan HJ. Regulation of interphotoreceptor retinoid-binding protein (IRBP)-specific Th1 and Th17 cells in anterior chamber-associated immune deviation (ACAID). Invest. Ophthalmol. Vis. Sci. 50: 5811-5817 (2009). *

• Cupedo T, Crellin NK, Papazian N, Rombouts EJ, Weijer K, Grogan JL, Fibbe WE, Cornelissen JJ, Spits H. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC(+) CD127(+) natural killer-like cells. Nat. Immunol. 10: 66-74 (2009). *

• Curtis MM, Way SS. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185 (2009). *

• Curtis MM, Way SS, Wilson CB. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J. Immunol. 183: 381-387 (2009).

• Cvjeticanin T, Miljkovic D, Stojanovic I, Dekanski D, Stosic-Grujicic S. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br. J. Nutr. Dec 22 [Epub ahead of print] (2009). *

• Cvjeticanin T, Stojanovic I, Timotijevic G, Stosic-Grujicic S, Miljkovic D. T cells cooperate with palmitic acid in induction of beta cell apoptosis. BMC Immunol. 10: 29 (2009). *

• D'Angelo C, De Luca A, Zelante T, Bonifazi P, Moretti S, Giovannini G, Iannitti RG, Zagarella S, Bozza S, Campo S, Salvatori G, Romani L. Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J. Immunol. 183: 4609-4618 (2009).

• da Matta Guedes PM, Gutierrez FR, Maia FL, Milanezi CM, Silva GK, Pavanelli WR, Silva JS. IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis. PLoS Negl. Trop. Dis. 4: e604 (2010). *

• Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J. Immunol. 181: 4279-4286 (2008). *

• Dai XG, Yao YM, Ai YH. Effect of apoptosis of CD4(+)CD25(+) regulatory T lymphocytes on polarization of helper T lymphocytes and potential interventional influence of Xuebijing injection in septic rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21: 135-138 (2009).

• Dai XG, Yao YM, Ai YH, Yu Y. The enhancing effect of "xuebijing injection" on lipopolysaccharide-induced apoptosis of regulatory T cells and mediation of polarization of helper T cells. Zhonghua Shao Shang Za Zhi 25: 106-110 (2009).

• Damsker JM, Hansen AM, Caspi RR. Th1 and Th17 cells. Ann. N. Y. Acad. Sci. 1183: 211-221 (2010). *

• Dander E, Balduzzi A, Zappa G, Lucchini G, Perseghin P, Andre V, Todisco E, Rahal D, Migliavacca M, Longoni D, Solinas G, Villa A, Berti E, Mina PD, Parma M, Allavena P, Biagi E, Rovelli A, Biondi A, D'Amico G. Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation. Transplantation 88: 1261-1272 (2009).

• Danesi F, Philpott M, Huebner C, Bordoni A, Ferguson LR. Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases. Mutat. Res. Jan 9 [Epub ahead of print] (2010).

• Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM. Immune modulatory treatment of TNBS colitis with calcitriol is associated with a change of a Th1/Th17 to a Th2 and regulatory T cell profile. J. Pharmacol. Exp. Ther. 324: 23-33 (2008). *

• Daniels MD, Hyland KV, Wang K, Engman DM. Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity. Autoimmunity 41: 490-499 (2008).

• Daoussis D, Andonopoulos AP, Liossis SN. Wnt pathway and IL-17: novel regulators of joint remodeling in rheumatic diseases. Looking beyond the RANK-RANKL-OPG Axis. Semin. Arthritis Rheum. Dec 16 [Epub ahead of print] (2008). *

• Dardalhon V, Korn T, Kuchroo VK, Anderson AC. Role of Th1 and Th17 cells in organ-specific autoimmunity. J. Autoimmun. 31: 252-256 (2008).

• Darrasse-Jeze G, Deroubaix S, Mouquet H, Victora GD, Eisenreich T, Yao KH, Masilamani RF, Dustin ML, Rudensky A, Liu K, Nussenzweig MC. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 206: 1853-1862 (2009). *

• Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med. 206: 2407-2416 (2009). *

• Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR. Interleukin 23 secretion by donor antigen presenting cells is critical for organ-specific pathology in graft versus host disease. Blood 113: 2352-2362 (2009). *

• Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso ML, Shafagh J, Fitzgerald DC, Shindler KS, Rostami AM. Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J. Neuroinflammation 6: 14 (2009).

• Datta S, Novotny M, Pavicic PG Jr, Zhao C, Herjan T, Hartupee J, Hamilton T. IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence. J. Immunol. Dec 30 [Epub ahead of print] (2009).

• Dave SH, Tilstra JS, Matsuoka K, Li F, Karrasch T, Uno JK, Sepulveda AR, Jobin C, Baldwin AS, Robbins PD, Plevy SE. Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J. Immunol. 179: 7852-7859 (2007). *

• Davoodi-Semiromi A, Schreiber M, Nalapalli S, Verma D, Singh ND, Banks RK, Chakrabarti D, Daniell H. Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery. Plant Biotechnol. J. Dec 28 [Epub ahead of print] (2009).

• de Beaucoudrey L, Puel A, Filipe-Santos O, Cobat A, Ghandil P, Chrabieh M, Feinberg J, von Bernuth H, Samarina A, Janniere L, Fieschi C, Stephan JL, Boileau C, Lyonnet S, Jondeau G, Cormier-Daire V, Le Merrer M, Hoarau C, Lebranchu Y, Lortholary O, et al. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J. Exp. Med. 205: 1543-1550 (2008). *

• de Boer OJ, van der Meer JJ, Teeling P, van der Loos CM, Idu MM, van Maldegem F, Aten J, van der Wal AC. Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J. Pathol. Nov 30 [Epub ahead of print] (2009). *

• de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin. Diagn. Lab. Immunol. 10: 133-139 (2003). *

• de Jong E, Suddason T, Lord GM. Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. Clin. Exp. Immunol. 159: 148-158 (2010). *

• De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2: 243-253 (2009).

• De Paiva CS, Hwang CS, Pitcher JD 3rd, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford) 49: 246-258 (2010).

• de Roock S, van Elk M, van Dijk ME, Timmerman HM, Rijkers GT, Prakken BJ, Hoekstra MO, de Kleer IM. Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans. Clin. Exp. Allergy Oct 7 [Epub ahead of print] (2009). *

• De Sanctis JB, Garmendia JV, Moreno D, Larocca N, Mijares M, Di Giulio C, Salazar-Bookaman M, Wojewodka G, Radzioch D. Pharmacological modulation of Th17. Recent Pat. Inflamm. Allergy Drug Discov. 3: 149-156 (2009).

• De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 181: 338-345 (2008). *

• De Vooght V, Vanoirbeek JA, Haenen S, Verbeken E, Nemery B, Hoet PH. Oropharyngeal aspiration: an alternative route for challenging in a mouse model of chemical-induced asthma. Toxicology 259: 84-89 (2009). *

• de Vries HS, Plantinga TS, van Krieken JH, Stienstra R, van Bodegraven AA, Festen EA, Weersma RK, Crusius JB, Linskens RK, Joosten LA, Netea MG, de Jong DJ. Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease. PLoS One 4: e7818 (2009). *

• de Waal Malefyt R. Interleukin-17 kick-starts T helper 1 cell differentiation. Immunity 31: 700-702 (2009). *

• Debes GF, Reiner SL. Helping and harming have something in common. Nat. Immunol. 10: 138-140 (2009). *

• Deepe Jr GS, Gibbons RS. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. J. Infect. Dis. 200: 142-151 (2009). *

• Deknuydt F, Bioley G, Valmori D, Ayyoub M. IL-1beta and IL-2 convert human Treg into T(H)17 cells. Clin. Immunol. 131: 298-307 (2009). *

• Deknuydt F, Scotet E, Bonneville M. Modulation of inflammation through IL-17 production by gammadelta T cells: mandatory in the mouse, dispensable in humans? Immunol. Lett. 127: 8-12 (2009).

• Delavallee L, Assier E, Denys A, Falgarone G, Zagury JF, Muller S, Bessis N, Boissier MC. Vaccination with cytokines in autoimmune diseases. Ann. Med. 40: 343-351 (2008).

• Delay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum. 60: 2633-2643 (2009). *

• Deleuran B, Abraham DJ. Possible implication of the effector CD4(+) T-cell subpopulation T(H)17 in the pathogenesis of systemic scleroderma. Nat. Clin. Pract. Rheumatol. 3: 682-683 (2007). *

• Delyria ES, Redline RW, Blanchard TG. Vaccination of mice against H. pylori induces a strong Th-17 response and immunity that is neutrophil dependent. Gastroenterology 136: 247-256 (2009). *

• Deng A, Yao D, Chen S, Liu C, Kang J, Zhou Y, Yu H, Qian C, Wu C, Jiang T, Zhong R, Pei G. beta-Arrestin 1 contributes to primary biliary cirrhosis. Clin. Sci. (Lond.) Dec 21 [Epub ahead of print] (2009). *

• Deng J, Younge BR, Olshen RA, Goronzy JJ, Weyand CM. Th17 and Th1 T-cell responses in giant cell arteritis. Circulation Feb 8 [Epub ahead of print] (2010).

• Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8: 1086-1094 (2007). *

• Derhovanessian E, Adams V, Hahnel K, Groeger A, Pandha H, Ward S, Pawelec G. Pretreatment frequency of circulating IL-17(+)CD4(+) T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int. J. Cancer 125: 1372-1379 (2009). *

• Desvignes L, Ernst JD. Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Immunity 31: 974-985 (2009). *

• Dharmani P, Chadee K. Biologic therapies against inflammatory bowel disease: a dysregulated immune system and the cross talk with gastrointestinal mucosa hold the key. Curr. Mol. Pharmacol. 1: 195-212 (2008).

• Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, Vesole D, Jagannath S, Dhodapkar MV. Dendritic cells mediate the induction of polyfunctional human IL17 producing cells (Th17-1 cells) enriched in the bone marrow of myeloma patients. Blood 112: 2878-2885 (2008). *

• Di Biaso I, Di Maio L, Bugarin C, Gaipa G, Dander E, Balduzzi A, Parma M, D'Amico G, Perseghin P, Biondi A, Biagi E. Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells. Transplantation 87: 1422-1425 (2009).

• Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J. Invest. Dermatol. 129: 1339-1350 (2009). *

• Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA, Corazza GR, Monteleone G, Macdonald TT. Blockade of transforming growth factor beta up-regulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 57: 605-612 (2008).

• Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NA, Wilde JI, Scott L, Corazza GR, Lee K, Sengupta N, Knowles CH, Gunthorpe MJ, McLean PG, Macdonald TT, Kruidenier L. Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J. Immunol. 183: 3454-3462 (2009).

• Di Stefano A, Caramori G, Gnemmi I, Contoli M, Vicari C, Capelli A, Magno F, D'Anna SE, Zanini A, Brun P, Casolari P, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin. Exp. Immunol. 157: 316-324 (2009). *

• Ding H, Nedrud JG, Wershil B, Redline RW, Blanchard TG, Czinn SJ. Partial protection against Helicobacter pylori in the absence of mast cells in mice. Infect. Immun. 77: 5543-5550 (2009). *

• Dioszeghy V, Rosas M, Maskrey BH, Colmont C, Topley N, Chaitidis P, Kuhn H, Jones SA, Taylor PR, O'Donnell VB. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. J. Immunol. 181: 6514-6524 (2008). *

• Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 182: 5748-5756 (2009).

• Dixit VD, Yang H, Cooper-Jenkins A, Giri BB, Patel K, Taub DD. Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation. Blood 113: 5202-5205 (2009). *

• Djoba Siawaya JF, Beyers N, van Helden P, Walzl G. Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis. Clin. Exp. Immunol. 156: 69-77 (2009). *

• Do JS, Fink PJ, Li L, Spolski R, Robinson J, Leonard WJ, Letterio JJ, Min B. Cutting edge: spontaneous development of IL-17-producing gammadelta T cells in the thymus occurs via a TGF-beta1-dependent mechanism. J. Immunol. Jan 8 [Epub ahead of print] (2010).

• Dodon MD, Li Z, Hamaia S, Gazzolo L. Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J. Gen. Virol. 85: 1921-1932 (2004). *

• Dogi CA, Galdeano CM, Perdigon G. Gut immune stimulation by non pathogenic Gram(+) and Gram(-) bacteria. Comparison with a probiotic strain. Cytokine 41: 223-231 (2008).

• Doherty SD, Ni X, Doherty CB, Jones D, Zhao X, Owen LB, Duvic M. Abnormal expression of interleukin-23 in mycosis fungoides/Sezary syndrome lesions. Arch. Dermatol. Res. 298: 353-356 (2006). *

• Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T. Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc. Natl. Acad. Sci. U.S.A. 105: 8381-8386 (2008). *

• Doisne JM, Becourt C, Amniai L, Duarte N, Le Luduec JB, Eberl G, Benlagha K. Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor gammat+ and respond preferentially under inflammatory conditions. J. Immunol. 183: 2142-2149 (2009).

• Dolgachev V, Petersen BC, Budelsky AL, Berlin AA, Lukacs NW. Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. J. Immunol. 183: 5705-5715 (2009).

• Dong C. IL-23/IL-17 biology and therapeutic considerations. J. Immunotoxicol. 5: 43-46 (2008).

• Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 6: 329-333 (2006). *

• Dong C. Differentiation and function of pro-inflammatory Th17 cells. Microbes Infect. 11: 584-588 (2009). *

• Dong C. Regulation and pro-inflammatory function of interleukin-17 family cytokines. Immunol. Rev. 226: 80-86 (2008). *

• Dong C. Mouse Th17 cells: current understanding of their generation and regulation. Eur. J. Immunol. 39: 640-644 (2009). *

• Dong X, Bachman LA, Miller MN, Nath KA, Griffin MD. Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. Kidney Int. 74: 1294-309 (2008). *

• Doodes PD, Cao Y, Hamel KM, Wang Y, Farkas B, Iwakura Y, Finnegan A. Development of proteoglycan-induced arthritis is independent of IL-17. J. Immunol. 181: 329-337 (2008). *

• Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Mikecz K, Glant TT, Iwakura Y, Finnegan A. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J. Immunol. Dec 18 [Epub ahead of print] (2009).

• Dooley JL, Abdel Latif D, St Laurent CD, Puttagunta L, Befus D, Lacy P. Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L1091-L1102 (2009). *

• Doreau A, Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, Fabien N, Cochat P, Pouteil-Noble C, Trolliet P, Durieu I, Tebib J, Kassai B, Ansieau S, Puisieux A, Eliaou JF, Bonnefoy-Berard N. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 10: 778-785 (2009). *

• Dos Santos JC, Azor MH, Nojima VA, Lourenco FD, Prearo E, Maruta CW, Rivitti EA, da Silva Duarte AJ, Sato MN. Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria. Int. Immunopharmacol. 8: 1433-1440 (2008).

• Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM. Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Infect. Immun. Nov 16 [Epub ahead of print] (2009). *

• Dragon S, Rahman MS, Yang J, Unruh H, Halayko AJ, Soussi-Gounni A. IL-17 enhances IL-1beta-mediated CXCL-8 release from human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L1023-L1029 (2007). *

• Drulovic J, Savic E, Pekmezovic T, Mesaros S, Stojsavljevic N, Dujmovic-Basuroski I, Kostic J, Vasic V, Stojkovic MM, Popadic D. Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment? J. Neuroimmunol. 215: 90-95 (2009).

• Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G. MicroRNA miR-326 regulates T(H)-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10: 1252-1259 (2009). *

• Du F, Lv L, Fu Q, Dai M, Fan W, Teng J, Chen S, Ye P, Shen N, Huang X, Qian J, Bao C. T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Res. Ther. 10: R136 (2008). *

• Du S, Sandoval F, Trinh P, Voskuhl RR. Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis. J. Neuroimmunol. Dec 14 [Epub ahead of print] (2009).

• Duan J, Chung H, Troy E, Kasper DL. Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells. Cell Host Microbe 7: 140-150 (2010).

• Dubin PJ, Kolls JK. IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L519-L528 (2007). *

• Dubin PJ, Kolls JK. Interleukin-17A and interleukin-17F: a tale of two cytokines. Immunity 30: 9-11 (2009). *

• Dubin PJ, Kolls JK. Th17 cytokines and mucosal immunity. Immunol. Rev. 226: 160-171 (2008). *

• Dubin PJ, McAllister F, Kolls JK. Is cystic fibrosis a TH(17) disease? Inflamm. Res. 56: 221-227 (2007). *

• Duerr RH. Genome-wide association studies herald a new era of rapid discoveries in inflammatory bowel disease research. Gastroenterology 132: 2045-2049 (2007). *

• Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol. 10: 857-863 (2009). *

• Dulos J, Kaptein A, Kavelaars A, Heijnen C, Boots A. Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b. Arthritis Res. Ther. 7: R1271-R1280 (2005). *

• Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 52: 770-778 (2005). *

• Dunford PJ, O'Donnell N, Riley JP, Williams KN, Karlsson L, Thurmond RL. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J. Immunol. 176: 7062-7070 (2006). *

• Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L. Peroxisome proliferator-activated receptor (PPAR) alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J. Exp. Med. 204: 321-330 (2007). *

• Duraisingham SS, Hornig J, Gotch F, Patterson S. TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol. 183: 2242-2251 (2009).

• Durelli L, Conti L, Clerico M, Boselli D, Contessa G, Ripellino P, Ferrero B, Eid P, Novelli F. T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta. Ann. Neurol. 65: 499-509 (2009).

• Durrant DM, Gaffen SL, Riesenfeld EP, Irvin CG, Metzger DW. Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17. J. Immunol. 183: 5293-5300 (2009).

• Dutzan N, Gamonal J, Silva A, Sanz M, Vernal R. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J. Clin. Periodontol. 36: 396-403 (2009).

• Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S. Foxp3(+) regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J. Clin. Immunol. Nov 20 [Epub ahead of print] (2009). *

• Ebbens FA, Georgalas C, Luiten S, van Drunen CM, Badia L, Scadding GK, Hellings PW, Jorissen M, Mullol J, Cardesin A, Bachert C, van Zele TP, Lund VJ, Fokkens WJ. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope 119: 401-408 (2009).

• Eberl M, Roberts GW, Meuter S, Williams JD, Topley N, Moser B. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog. 5: e1000308 (2009). *

• Edgerton C, Crispín JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC. IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin. Immunol. 130: 313-321 (2009). *

• Edwards LJ, Constantinescu CS. Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. Inflamm. Allergy Drug Targets 8: 182-190 (2009).

• Edwards LJ, Constantinescu CS. Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. Inflamm. Allergy Drug Targets 8: 182-190 (2009).

• Edwards LJ, Robins RA, Constantinescu CS. Th17/Th1 phenotype in demyelinating disease. Cytokine Dec 31 [Epub ahead of print] (2009).

• Ehirchiou D, Xiong Y, Xu G, Chen W, Shi Y, Zhang L. CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J. Exp. Med. 204: 1519-1524 (2007). *

• Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation 119: 1424-1432 (2009).

• Eklund CM. Proinflammatory cytokines in CRP baseline regulation. Adv. Clin. Chem. 48: 111-136 (2009).

• El-Behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J. Immunol. 183: 4957-4967 (2009). *

• El-Behi M, Rostami A, Ciric B. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. Jan 27 [Epub ahead of print] (2010).

• Elder JT. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes Immun. 10: 201-209 (2009). *

• Elder JT. IL-15 and psoriasis: another genetic link to Th17? J. Invest. Dermatol. 127: 2495-2497 (2007). *

• Elhofy A, Depaolo RW, Lira SA, Lukacs NW, Karpus WJ. Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis. J. Neuroimmunol. 213: 91-99 (2009).

• Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111: 1013-1020 (2008). *

• Elliott DE, Metwali A, Leung J, Setiawan T, Blum AM, Ince MN, Bazzone LE, Stadecker MJ, Urban JF Jr, Weinstock JV. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. J. Immunol. 181: 2414-2419 (2008). *

• Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132: 2359-2370 (2007). *

• Ely LK, Fischer S, Garcia KC. Structural basis of receptor sharing by interleukin 17 cytokines. Nat. Immunol. 10: 1245-1251 (2009). *

• Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisakk P, Chiba S, Yagita H, Khoury SJ. Jagged1 and Delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179: 5990-5998 (2007). *

• Elyaman W, Kivisakk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am. J. Pathol. 173: 411-422 (2008). *

• Emamaullee JA, Davis J, Merani S, Toso C, Elliott JF, Thiesen A, Shapiro AM. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes 58: 1302-1311 (2009). *

• Emanuele E, Bertona M. Interleukin-17-targeted treatment of alcoholic liver disease. Hepatology 50: 329-330 (2009). *

• Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. Neuronal IkappaB kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J. Immunol. 183: 7877-7889 (2009).

• Emoto M, Emoto Y, Yoshizawa I, Kita E, Shimizu T, Hurwitz R, Brinkmann V, Kaufmann SH. alpha-Galactosylceramide ameliorates murine listeriosis by accelerating infiltration of Gr-1(+) cells and gamma/deltaT cells into the liver. Eur. J. Immunol. Feb 16 [Epub ahead of print] (2010). *

• Erbel C, Chen L, Bea F, Wangler S, Celik S, Lasitschka F, Wang Y, Bockler D, Katus HA, Dengler TJ. Inhibition of IL-17A attenuates atherosclerotic lesion development in ApoE-deficient mice. J. Immunol. 183: 8167-8175 (2009).

• Erdman SE, Rao VP, Olipitz W, Taylor CL, Jackson EA, Levkovich T, Lee CW, Horwitz BH, Fox JG, Ge Z, Poutahidis T. Unifying roles for regulatory T cells and inflammation in cancer. Int. J. Cancer Sep 30 [Epub ahead of print] (2009). *

• Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjostrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J. Exp. Med. 206: 1661-1671 (2009). *

• Esposito M, Ruffini F, Bellone M, Gagliani N, Battaglia M, Martino G, Furlan R. Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J. Neuroimmunol. Feb 9 [Epub ahead of print] (2010).

• Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc. Natl. Acad. Sci. U.S.A. 106: 6232-6237 (2009). *

• Evans HG, Suddason T, Jackson I, Taams LS, Lord GM. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl. Acad. Sci. U.S.A. 104: 17034-17039 (2007). *

• Eyerich K, Foerster S, Rombold S, Seidl HP, Behrendt H, Hofmann H, Ring J, Traidl-Hoffmann C. Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. J. Invest. Dermatol. 128: 2640-2645 (2008). *

• Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol. 123: 59-66.e4 (2009). *

• Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, Cianfarani F, Odorisio T, Traidl-Hoffmann C, Behrendt H, Durham SR, Schmidt-Weber CB, Cavani A. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J. Clin. Invest. 119: 3573-3585 (2009). *

• Fabis MJ, Phares TW, Kean RB, Koprowski H, Hooper DC. Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity. Proc. Natl. Acad. Sci. U.S.A. 105: 15511-15516 (2008). *

• Fabrega E, Lopez-Hoyos M, San Segundo D, Casafont F, Benito MJ, Pons-Romero F. Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and -23 in stable liver transplant recipients. Transplant. Proc. 41: 1025-1027 (2009). *

• Fabrega E, Lopez-Hoyos M, San Segundo D, Casafont F, Pons-Romero F. Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation. Liver Transpl. 15: 629-633 (2009).

• Fan HC, Ren XR, Yu JZ, Guo MF, Ji N, Sun YS, Liang LY, Ma CG. Suppression of murine EAE by Triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25: 222-225 (2009).

• Fan YY, Wu CY. The role of cytokines in the production of IL-17 and IFN-gamma via the induction of normal human peripheral blood mononuclear cells and CD4(+) T cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 914-916 (2007).

• Fang J, Fang D, Silver PB, Wen F, Li B, Ren X, Lin Q, Caspi RR, Su SB. The role of TLR2, TLR3, TLR4 and TLR9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model. Invest. Ophthalmol. Vis. Sci. Jan 27 [Epub ahead of print] (2010).

• Fang W, Yang P. Vogt-Koyanagi-Harada syndrome. Curr. Eye Res. 33: 517-523 (2008).

• Fang Y, Yu S, Ellis JS, Sharav T, Braley-Mullen H. Comparison of sensitivity of Th1, Th2, and Th17 cells with Fas-mediated apoptosis. J. Leukoc. Biol. Feb 23 [Epub ahead of print] (2010). *

• Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur. J. Immunol. 37: 3155-3163 (2007). *

• Faour WH, Alaaeddine N, Mancini A, He QW, Jovanovic D, Di Battista JA. Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts. J. Biol. Chem. 280: 9536-9546 (2005). *

• Farago B, Magyari L, Safrany E, Csongei V, Jaromi L, Horvatovich K, Sipeky C, Maasz A, Radics J, Gyetvai A, Szekanecz Z, Czirjak L, Melegh B. Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis. Ann. Rheum. Dis. 67: 248-250 (2008).

• Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK. Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J. Immunol. 183: 7297-7306 (2009). *

• Faustini F, Zoli A, Ferraccioli GF. Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases. Eur. Rev. Med. Pharmacol. Sci. 13 Suppl. 1: 1-9 (2009).

• Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 5: e1000295 (2009). *

• Feinen B, Jerse AE, Gaffen SL, Russell MW. Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal Immunol. Jan 27 [Epub ahead of print] (2010).

• Feng W, Li W. The study of ISO induced heart failure rat model. Exp. Mol. Pathol. Nov 10 [Epub ahead of print] (2009).

• Feng W, Li W, Liu W, Wang F, Li Y, Yan W. IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. Exp. Mol. Pathol. 87: 212-218 (2009). *

• Fennelly NK, Sisti F, Higgins SC, Ross PJ, van der Heide H, Mooi FR, Boyd A, Mills KH. Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses. Infect. Immun. 76: 1257-1266 (2008). *

• Fenoglio D, Poggi A, Catellani S, Battaglia F, Ferrera A, Setti M, Murdaca G, Zocchi MR. Vdelta1 T lymphocytes producing IFNgamma and IL-17 are expanded in HIV-1 infected patients and respond to Candida albicans. Blood 113: 6611-6618 (2009). *

• Fernandes BF, Rezende AB, Alves CC, Teixeira FM, Farias RE, Ferreira AP, Teixeira HC. Splenic autotransplantation restores IL-17 production and antibody response to Streptococcus pneumoniae in splenectomized mice. Transpl. Immunol. Dec 23 [Epub ahead of print] (2009).

• Fernandez P, Guillen MI, Gomar F, Alcaraz MJ. Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes. Biochem. Pharmacol. 66: 2049-2052 (2003). *

• Ferrari-Lacraz S, Zanelli E, Neuberg M, Donskoy E, Kim YS, Zheng XX, Hancock WW, Maslinski W, Li XC, Strom TB, Moll T. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J. Immunol. 173: 5818-5826 (2004). *

• Ferreira DM, Darrieux M, Silva DA, Leite LC, Ferreira JM Jr, Ho PL, Miyaji EN, Oliveira ML. Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface proteins PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice. Clin. Vaccine Immunol. 16: 636-645 (2009). *

• Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, Jacobs L, Jansen T, Verheijen K, Masthoff L, Morre SA, Vriend G, Williams DL, Perfect JR, Joosten LA, Wijmenga C, et al. Human dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 361: 1760-1767 (2009). *

• Fichtner-Feigl S, Fuss IJ, Preiss JC, Strober W, Kitani A. Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappaB decoy oligonucleotides. J. Clin. Invest. 115: 3057-3071 (2005). *

• Fichtner-Feigl S, Fuss IJ, Young CA, Watanabe T, Geissler EK, Schlitt HJ, Kitani A, Strober W. Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J. Immunol. 178: 5859-5870 (2007). *

• Fichtner-Feigl S, Strober W, Geissler EK, Schlitt HJ. Cytokines mediating the induction of chronic colitis and colitis-associated fibrosis. Mucosal Immunol. 1 Suppl. 1: S24-S27 (2008).

• Fietta P, Delsante G. The effector T helper cell triade. Riv. Biol. 102: 61-74 (2009).

• Figueroa-Vega N, Alfonso-Perez M, Benedicto I, Sanchez-Madrid F, Gonzalez-Amaro R, Marazuela M. Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. Dec 16 [Epub ahead of print] (2009). *

• Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG. Transforming growth factor-beta suppresses the activation of CD8+ T cells when naive but promotes their survival and function once antigen-experienced: a two-faced impact on autoimmunity. Diabetes 57: 2684-2692 (2008). *

• Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I, Dottori M, Boirivant M, Pallone F, Macdonald TT, Monteleone G. Regulation of gut inflammation and Th17 cell response by interleukin-21. Gastroenterology 134: 1038-1048 (2008). *

• Finkelman FD, Hogan SP, Hershey GK, Rothenberg ME, Wills-Karp M. Importance of cytokines in murine allergic airway disease and human asthma. J. Immunol. 184: 1663-1674 (2010).

• Finnerty CC, Przkora R, Herndon DN, Jeschke MG. Cytokine expression profile over time in burned mice. Cytokine 45: 20-25 (2009).

• Fisman EZ, Adler Y, Tenenbaum A. Biomarkers in cardiovascular diabetology: interleukins and matrixins. Adv. Cardiol. 45: 44-64 (2008).

• Fitch E, Harper E, Skorcheva I, Kurtz SE, Blauvelt A. Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr. Rheumatol. Rep. 9: 461-467 (2007).

• Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, Sarma JD, Gran B, Zhang GX, Rostami A. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179: 3268-3275 (2007). *

• Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8: 1372-1379 (2007). *

• Fitzpatrick LR, Meirelles K, Small JS, Puleo FJ, Koltun WA, Cooney RN. A new model of chronic hapten-induced colitis in young rats. J. Pediatr. Gastroenterol. Nutr. Jan 27 [Epub ahead of print] (2010).

• Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH. CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J. Immunol. 183: 7602-7610 (2009). *

• Fletcher MA, Zeng XR, Barnes Z, Levis S, Klimas NG. Plasma cytokines in women with chronic fatigue syndrome. J. Transl. Med. 7: 96 (2009). *

• Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA. Adverse functions of IL-17A in experimental sepsis. FASEB J. 22: 2198-2205 (2008). *

• Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A. 105: 19396-19401 (2008). *

• Foerster A, Assenmacher M, Niemoeller M, Rankin E, Mohaupt M, Richter A. Detection and isolation of viable mouse IL-17-secreting T cells. J. Vis. Exp. 22: pii: 1037 (2008). *

• Foley JF. STAT3 regulates the generation of Th17 cells. Sci. STKE 380: tw113 (2007).

• Fong DJ, Hogaboam CM, Matsuno Y, Akira S, Uematsu S, Joshi AD. Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis. Immunology Jan 11 [Epub ahead of print] (2010). *

• Fonseca DM, Silva CL, Wowk PF, Paula MO, Ramos SG, Horn C, Marchal G, Bonato VL. Mycobacterium tuberculosis culture filtrate proteins plus CpG-ODN confer protection to BCG primed mice by inhibiting IL-4 secretion. Infect. Immun. 77: 5311-5321 (2009). *

• Fossiez F, Banchereau J, Murray R, Van Kooten C, Garrone P, Lebecque S. Interleukin-17. Int. Rev. Immunol. 16: 541-551 (1998).

• Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S, Blanchard D, Gaillard C, Das Mahapatra B, Rouvier E, Golstein P, Banchereau J, Lebecque S. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183: 2593-2603 (1996). *

• Fouser LA, Wright JF, Dunussi-Joannopoulos K, Collins M. Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol. Rev. 226: 87-102 (2008). *

• Frangen TM, Bogdanski D, Schinkel C, Roetman B, Kalicke T, Muhr G, Koller M. Systemic IL-17 after severe injuries. Shock 29: 462-467 (2008). *

• Fransen JH, Hilbrands LB, Ruben J, Stoffels M, Adema GJ, van der Vlag J, Berden JH. Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum. 60: 2304-2313 (2009). *

• Fransson ME, Liljenfeldt LS, Fagius J, Totterman TH, Loskog AS. The T-cell pool is anergized in patients with multiple sclerosis in remission. Immunology 126: 92-101 (2009). *

• Freitag T, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- effector/memory T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice. Gut 58: 1597-1605 (2009).

• Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B. IL-17 receptor signaling is required to control polymicrobial sepsis. J. Immunol. 182: 7846-7854 (2009).

• Fu Y, Tong JJ, Pan Q, Wang WF, Zou KF, Qian W, Hou XH. Phenotypic analysis of Th cells in colon and peripheral blood in patients with irritable bowel syndrome. Zhonghua Yi Xue Za Zhi 89: 2120-2123 (2009).

• Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X. Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection. J. Huazhong Univ. Sci. Technolog. Med. Sci. 29: 481-485 (2009).

• Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W, Hou X. Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis. Mediators Inflamm. 2009: 517052 (2009). *

• Fujimoto M, Serada S, Naka T. Role of IL-6 in the development and pathogenesis of CIA and EAE. Nihon Rinsho Meneki Gakkai Kaishi 31: 78-84 (2008).

• Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Bamba T, Fujiyama Y. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52: 65-70 (2003). *

• Fujio K, Okamoto A, Araki Y, Shoda H, Tahara H, Tsuno NH, Takahashi K, Kitamura T, Yamamoto K. Gene therapy of arthritis with TCR isolated from the inflamed paw. J. Immunol. 177: 8140-8147 (2006). *

• Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R. Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm. J. Immunol. 183: 6236-6243 (2009).

• Fujishima S, Watanabe H, Kawaguchi M, Suzuki T, Matsukura S, Homma T, Howell BG, Hizawa N, Mitsuya T, Huang SK, Iijima M. Involvement of IL-17F via the induction of IL-6 in psoriasis. Arch. Dermatol. Res. Feb 11 [Epub ahead of print] (2010). *

• Fujita H, Nograles KE, Kikuchi T, Gonzalez J, Carucci JA, Krueger JG. Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production. Proc. Natl. Acad. Sci. U.S.A. Dec 8 [Epub ahead of print] (2009). *

• Fujita M, Otsuka T, Mizuno M, Tomi C, Yamamura T, Miyake S. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via an iNKT cell-dependent mechanism. Am. J. Pathol. 175: 1116-1123 (2009). *

• Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H. T-bet inhibits both T(H)2 cell-mediated eosinophil recruitment and T(H)17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol. 119: 662-670 (2007). *

• Fukami N, Ramachandran S, Saini D, Walter M, Chapman W, Patterson GA, Mohanakumar T. Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection. J. Immunol. 182: 309-318 (2009). *

• Fukata M, Breglio K, Chen A, Vamadevan AS, Goo T, Hsu D, Conduah D, Xu R, Abreu MT. The myeloid differentiation factor 88 (Myd88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J. Immunol. 180: 1886-1894 (2008). *

• Fukushima A, Sumi T, Ishida W, Yamada J, Iwakura Y, Ueno H. Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis. Int. Arch. Allergy Immunol. 147: 206-212 (2008).

• Furuya T, Hakoda M, Ichikawa N, Higami K, Nanke Y, Yago T, Kamatani N, Kotake S. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. Clin. Rheumatol. 26: 2137-2141 (2007). *

• Furuzawa-Carballeda J, Vargas-Rojas MI, Cabral AR. Autoimmune inflammation from the Th17 perspective. Autoimmun. Rev. 6: 169-175 (2007). *

• Furze RC, Rankin SM. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 22: 3111-3119 (2008). *

• Fuss IJ, Becker C, Yang Z, Groden C, Hornung RL, Heller F, Neurath MF, Strober W, Mannon PJ. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12: 9-15 (2006). *

• Gabay C, McInnes IB. The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases. Arthritis Res. Ther. 11: 230 (2009).

• Gaffen SL. Biology of recently discovered cytokines: interleukin-17 - a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis Res. Ther. 6: 240-247 (2004). *

• Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9: 556-567 (2009). *

• Gaffen SL. An overview of IL-17 function and signaling. Cytokine 43: 402-407 (2008).

• Gaffen SL. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr. Rheumatol. Rep. 11: 365-370 (2009).

• Gaffen SL, Hajishengallis G. A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J. Dent. Res. 87: 817-828 (2008). *

• Gaffen SL, Kramer JM, Yu JJ, Shen F. The IL-17 cytokine family. Vitam. Horm. 74: 255-282 (2006).

• Galdo FD, Jimenez SA. T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro. Arthritis Rheum. 56: 3478-3488 (2007). *

• Galicia G, Kasran A, Uyttenhove C, De Swert K, Van Snick J, Ceuppens JL. ICOS deficiency results in exacerbated IL-17 mediated experimental autoimmune encephalomyelitis. J. Clin. Immunol. 29: 426-433 (2009). *

• Galicia G, Maes W, Verbinnen B, Kasran A, Bullens D, Arredouani M, Ceuppens JL. Haptoglobin deficiency facilitates the development of autoimmune inflammation. Eur. J. Immunol. 39: 3404-3412 (2009). *

• Gao W, Thompson L, Zhou Q, Putheti P, Fahmy TM, Strom TB, Metcalfe SM. Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle 8: 1444-1450 (2009). *

• Gardner RM, Nyland JF, Evans SL, Wang SB, Doyle KM, Crainiceanu CM, Silbergeld EK. Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ. Health Perspect. 117: 1932-1938 (2009). *

• Garlet GP, Giozza SP, Silveira EM, Claudino M, Santos SB, Avila-Campos MJ, Martins Jr W, Cardoso CR, Trombone AP, Campanelli AP, Carvalho EM, Silva JS. Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection. Clin. Infect. Dis. Dec 28 [Epub ahead of print] (2009). *

• Garley M, Jablonska E. Chosen IL-17 family proteins in neutrophils of patients with oral inflammation. Adv. Med. Sci. 53: 326-330 (2008). *

• Garley M, Jablonska E, Grabowska SZ, Piotrowski L. IL-17 family cytokines in neutrophils of patients with oral epithelial squamous cell carcinoma. Neoplasma 56: 96-100 (2009).

• Garrett-Sinha LA, John S, Gaffen SL. IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr. Opin. Rheumatol. 20: 519-525 (2008).

• Garweg JG, Candolfi E. Immunopathology in ocular toxoplasmosis: facts and clues. Mem. Inst. Oswaldo Cruz 104: 211-220 (2009). *

• Ge D, You Z. Expression of interleukin-17RC protein in normal human tissues. Int. Arch. Med. 1: 19 (2008). *

• Ge J, Wang K, Meng QH, Qi ZX, Meng FL, Fan YC. Implication of Th17 and Th1 cells in patients with chronic active hepatitis B. J. Clin. Immunol. Sep 10 [Epub ahead of print] (2009). *

• Ge Z, Sterzenbach T, Whary MT, Rickman BH, Rogers AB, Shen Z, Taylor NS, Schauer DB, Josenhans C, Suerbaum S, Fox JG. Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. Microbes Infect. 10: 726-733 (2008). *

• Gebe JA, Unrath KA, Yue BB, Miyake T, Falk BA, Nepom GT. Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J. Autoimmun. 30: 197-206 (2008).

• Genovese M, Van den Bosch F, Roberson S, Bojin S, Biagini I, Ryan P, Sloan-Lancaster J. LY2439821, a humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis. Arthritis Rheum. Jan 21 [Epub ahead of print] (2010). *

• George-Chandy A, Nordstrom I, Nygren E, Jonsson IM, Postigo J, Collins LV, Eriksson K. Th17 development and autoimmune arthritis in the absence of reactive oxygen species. Eur. J. Immunol. 38: 1118-1126 (2008). *

• Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA, Davies RA, Needham MR, Langham C, Barker W, Aziz A, Snow MJ, Dawson S, Welsh F, Wilkinson T, Vaugan T, Beste G, Bishop S, Popovic B, Rees G, Sleeman M, Tuske SJ, Coales SJ, Hamuro Y, Russell C. Structure of IL-17A in complex with a potent, fully human neutralising antibody. J. Mol. Biol. 394: 905-921 (2009). *

• Gerosa F, Baldani-Guerra B, Lyakh LA, Batoni G, Esin S, Winkler-Pickett RT, Consolaro MR, De Marchi M, Giachino D, Robbiano A, Astegiano M, Sambataro A, Kastelein RA, Carra G, Trinchieri G. Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J. Exp. Med. 205: 1447-1461 (2008). *

• Ghilardi N, Ouyang W. Targeting the development and effector functions of TH17 cells. Semin. Immunol. 19: 383-393 (2007). *

• Ghoreschi K, Weigert C, Rocken M. Immunopathogenesis and role of T cells in psoriasis. Clin. Dermatol. 25: 574-580 (2007).

• Glader P, Smith ME, Malmhall C, Balder B, Sjostrand M, Qvarfordt I, Linden A. IL-17-producing T helper cells and Th17 cytokines in human airways exposed to endotoxin. Eur. Respir. J. Feb 25 [Epub ahead of print] (2010).

• Glaser R, Meyer-Hoffert U, Harder J, Cordes J, Wittersheim M, Kobliakova J, Folster-Holst R, Proksch E, Schroder JM, Schwarz T. The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption. J. Invest. Dermatol. 129: 641-649 (2009). *

• Glatigny S, Blaton MA, Mencher SK, Mistou S, Lucas B, Fournier C, Wang LG, Chiocchia G. Treatment of collagen-induced arthritis by Natura-alpha via regulation of Th-1/Th-17 responses. Eur. J. Immunol. Jan 13 [Epub ahead of print] (2010). *

• Glocker EO, Hennigs A, Nabavi M, Schaffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschlager N, Gross O, Ruland J, Grimbacher B. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N. Engl. J. Med. 361: 1727-1735 (2009). *

• Gocke AR, Cravens PD, Ben LH, Hussain RZ, Northrop SC, Racke MK, Lovett-Racke AE. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol. 178: 1341-1348 (2007). *

• Godinez I, Haneda T, Raffatellu M, George MD, Paixao TA, Rolan HG, Santos RL, Dandekar S, Tsolis RM, Baumler AJ. T cells help to amplify inflammatory responses induced by Salmonella enterica serotype typhimurium in the intestinal mucosa. Infect. Immun. 76: 2008-2017 (2008). *

• Godinez I, Raffatellu M, Chu H, Paixao TA, Haneda T, Santos RL, Bevins CL, Tsolis RM, Baumler AJ. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect. Immun. 77: 387-398 (2009). *

• Godoy L. World Immune Regulation Meeting (WIRM) - III: Special focus on regulatory and effector mechanisms. Drug News Perspect. 22: 623-626 (2009).

• Goetzl EJ. Changing paradigms in the immunological science of allergy. Curr. Allergy Asthma Rep. 7: 7-10 (2007).

• Gold R, Luhder F. Interleukin-17 - extended features of a key player in multiple sclerosis. Am. J. Pathol. 172: 8-10 (2008). *

• Goldberg M, Nadiv O, Luknar-Gabor N, Agar G, Beer Y, Katz Y. Synergism between tumor necrosis factor alpha and interleukin-17 to induce IL-23 p19 expression in fibroblast-like synoviocytes. Mol. Immunol. 46: 1854-1859 (2009). *

• Gomez-Rodriguez J, Sahu N, Handon R, Davidson TS, Anderson SM, Kirby MR, August A, Schwartzberg PL. Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity 31: 587-597 (2009). *

• Goncalves-Sousa N, Ribot JC, Debarros A, Correia DV, Caramalho I, Silva-Santos B. Inhibition of murine lymphocyte expansion and effector function by regulatory T cells is cell contact-dependent and sensitive to GITR modulation. Eur. J. Immunol. Oct 28 [Epub ahead of print] (2009). *

• Gonzalez-Alvaro I, Ortiz Garcia AM, Dominguez-Jimenez C, Aragon-Bodi A, Díaz-Sanchez B, Sanchez-Madrid F. Inhibition of TNF and IL-17 production by leflunomide involves the JAK/STAT pathway. Ann. Rheum. Dis. 68: 1644-1650 (2009). *

• Gonzalez-García I, Zhao Y, Ju S, Gu Q, Liu L, Kolls JK, Lu B. IL-17 signaling-independent central nervous system autoimmunity is negatively regulated by TGF-beta. J. Immunol. 182: 2665-2671 (2009).

• Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, Cooper KD. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J. Immunol. 183: 3170-3176 (2009).

• Gordon JN, Sabatino AD, Macdonald TT. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr. Opin. Gastroenterol. 21: 431-437 (2005).

• Gordon MA. Salmonella infections in immunocompromised adults. J. Infect. 56: 413-422 (2008).

• Goriely S, Goldman M. Interleukin-12 family members and the balance between rejection and tolerance. Curr. Opin. Organ Transplant. 13: 4-9 (2008).

• Goriely S, Goldman M. The interleukin-12 family: new players in transplantation immunity? Am. J. Transplant. 7: 278-284 (2007). *

• Goswami J, Hernandez-Santos N, Zuniga LA, Gaffen SL. A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss. Eur. J. Immunol. 39: 2831-2839 (2009). *

• Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T. Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Cell. Immunol. 258: 147-151 (2009). *

• Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Nagahira K, Fukuda Y, Nishimura T. Murine NKT cells produce Th17 cytokine interleukin-22. Cell. Immunol. 254: 81-84 (2009). *

• Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res. 69: 5490-5497 (2009). *

• Gourh P, Arnett FC, Assassi S, Tan FK, Huang M, Diekman L, Mayes MD, Reveille JD, Agarwal SK. Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations. Arthritis Res. Ther. 11: R147 (2009). *

• Gove ME, Pini M, Fayad R, Cabay RJ, Fantuzzi G. Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis. Cytokine 47: 119-125 (2009).

• Goverman J. Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9: 393-407 (2009). *

• Graber JJ, Allie SR, Mullen KM, Jones MV, Wang T, Krishnan C, Kaplin AI, Nath A, Kerr DA, Calabresi PA. Interleukin-17 in transverse myelitis and multiple sclerosis. J. Neuroimmunol. 196: 124-132 (2008).

• Grajewski RS, Hansen AM, Agarwal RK, Kronenberg M, Sidobre S, Su SB, Silver PB, Tsuji M, Franck RW, Lawton AP, Chan CC, Caspi RR. Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J. Immunol. 181: 4791-4797 (2008). *

• Granet C, Maslinski W, Miossec P. Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes. Arthritis Res. Ther. 6: R190-R198 (2004). *

• Granet C, Miossec P. Combination of the pro-inflammatory cytokines IL-1, TNF-alpha and IL-17 leads to enhanced expression and additional recruitment of AP-1 family members, Egr-1 and NF-kappaB in osteoblast-like cells. Cytokine 26: 169-177 (2004).

• Gras R, Almonacid L, Ortega P, Serramia MJ, Gomez R, de la Mata FJ, Lopez-Fernandez LA, Munoz-Fernandez MA. Changes in gene expression pattern of human primary macrophages induced by carbosilane dendrimer 2G-NN16. Pharm. Res. 26: 577-586 (2009). *

• Gravallese EM. Bone destruction in arthritis. Ann. Rheum. Dis. 61 Suppl. 2: ii84-ii86 (2002). *

• Gregerson DS, Heuss ND, Lew KL, McPherson SW, Ferrington DA. Interaction of retinal pigmented epithelial cells and CD4 T cells leads to T-cell anergy. Invest. Ophthalmol. Vis. Sci. 48: 4654-4663 (2007). *

• Grevers LC, van Lent PL, Koenders MI, Walgreen B, Sloetjes AW, Nimmerjahn F, Sjef Verbeek J, van den Berg WB. Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis. Arthritis Rheum. 60: 396-407 (2009). *

• Gruenbacher G, Gander H, Rahm A, Nussbaumer W, Romani N, Thurnher M. CD56+ human blood dendritic cells effectively promote TH1-type gammadelta T cell responses. Blood 114: 4422-4431 (2009). *

• Gu J, Wei YL, Wei JC, Huang F, Jan MS, Centola M, Frank MB, Yu D. Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reaction. Arthritis Rheum. 60: 3269-3279 (2009). *

• Gu Y, Hu X, Liu C, Qv X, Xu C. Interleukin (IL)-17 promotes macrophages to produce IL-8, IL-6 and tumour necrosis factor-alpha in aplastic anaemia. Br. J. Haematol. 142: 109-114 (2008). *

• Gu Y, Yang J, Ouyang X, Liu W, Li H, Yang J, Bromberg J, Chen SH, Mayer L, Unkeless JC, Xiong H. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur. J. Immunol. 38: 1807-1813 (2008). *

• Guerrero A, Jain N, Wang X, Fries BC. Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation. Infect. Immun. Jan 4 [Epub ahead of print] (2010). *

• Guichelaar T, Ten Brink CB, van Kooten PJ, Berlo SE, Broeren CP, van Eden W, Broere F. Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response. J. Immunol. 180: 1373-1381 (2008). *

• Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 118: 1680-1690 (2008). *

• Guo JP, Backdahl L, Marta M, Mathsson L, Ronnelid J, Lorentzen JC. Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex. Arthritis Rheum. 58: 1343-1353 (2008). *

• Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13463-13468 (2009). *

• Guo P, Hirano M, Herrin BR, Li J, Yu C, Sadlonova A, Cooper MD. Dual nature of the adaptive immune system in lampreys. Nature 459: 796-801 (2009). *

• Guo S, Cobb D, Smeltz RB. T-bet inhibits the in vivo differentiation of parasite-specific CD4+ Th17 cells in a T cell-intrinsic manner. J. Immunol. 182: 6179-6186 (2009).

• Guo X, Barroso L, Becker SM, Lyerly DM, Vedvick TS, Reed SG, Petri WA Jr, Houpt ER. Protection against intestinal amebiasis by a recombinant vaccine is transferable by T cells and mediated by IFN-gamma. Infect. Immun. 77: 3909-3918 (2009). *

• Guo Z, Zheng C, Chen Z, Gu D, Du W, Ge J, Han Z, Yang R. Fetal bone marrow-derived mesenchymal stem cells promote the expansion of human Th17 cells, but inhibit the production of Th1 cells. Eur. J. Immunol. 39: 2840-2849 (2009). *

• Gutcher I, Urich E, Wolter K, Prinz M, Becher B. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation. Nat. Immunol. 7: 946-953 (2006). *

• Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG. Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis. J. Immunol. 181: 7420-7427 (2008). *

• Guzik TJ, Marvar PJ, Czesnikiewicz-Guzik M, Korbut R. Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction. J. Physiol. Pharmacol. 58: 591-610 (2007). *

• Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, Waisman A. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 119: 61-69 (2009). *

• Haas JD, Gonzalez FH, Schmitz S, Chennupati V, Fohse L, Kremmer E, Forster RJ, Prinz I. CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur. J. Immunol. 39: 3488-3497 (2009). *

• Haider AS, Lowes MA, Suarez-Farinas M, Zaba LC, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG. Identification of cellular pathways of "type 1," Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine a in psoriasis. J. Immunol. 180: 1913-1920 (2008). *

• Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, Grigg ME, Berzofsky JA, Belkaid Y. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29: 637-649 (2008). *

• Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J. Immunol. 182: 3469-3481 (2009).

• Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O'Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T, Matsuzaki G. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J. Immunol. 181: 3456-3463 (2008). *

• Hamel K, Doodes P, Cao Y, Wang Y, Martinson J, Dunn R, Kehry MR, Farkas B, Finnegan A. Suppression of proteoglycan-induced arthritis by anti-CD20 B cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity. J. Immunol. 180: 4994-5003 (2008). *

• Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand. J. Rheumatol. 31: 205-210 (2002).

• Han G, Wang R, Chen G, Wang J, Xu R, Wang L, Feng J, Li X, Guo R, Fu L, Shen B, Li Y. Interleukin-17-producing gammadelta(+) T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology 129: 197-206 (2010). *

• Harada K, Shimoda S, Sato Y, Isse K, Ikeda H, Nakanuma Y. Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin. Exp. Immunol. 157: 261-270 (2009). *

• Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL Jr. Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection. Am. J. Pathol. Jan 7 [Epub ahead of print] (2010). *

• Harle P, Pongratz G, Albrecht J, Tarner IH, Straub RH. An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum. 58: 2347-2355 (2008). *

• Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J. Invest. Dermatol. 129: 2175-2183 (2009). *

• Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6: 1123-1132 (2005). *

• Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18: 349-356 (2006). *

• Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, Walsh PT. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol. Lett. 121: 13-21 (2008).

• Hartgring SA, Bijlsma JW, Lafeber FP, van Roon JA. Interleukin-7 induced immunopathology in arthritis. Ann. Rheum. Dis. 65 Suppl. 3: iii69-iii74 (2006). *

• Hartupee J, Liu C, Novotny M, Li X, Hamilton T. IL-17 enhances chemokine gene expression through mRNA stabilization. J. Immunol. 179: 4135-4141 (2007). *

• Hartupee J, Liu C, Novotny M, Sun D, Li X, Hamilton TA. IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6. J. Immunol. 182: 1660-1666 (2009).

• Hashimoto K, Inoue T, Higashi T, Takei SI, Awata T, Katayama S, Takagi R, Okada H, Matsushita S. Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice. Biochem. Biophys. Res. Commun. 383: 460-463 (2009). *

• Hashimoto T, Akiyama K, Kobayashi N, Mori A. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int. Arch. Allergy Immunol. 137 Suppl. 1: 51-54 (2005).

• Hashizume M, Hayakawa N, Mihara M. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. Rheumatology (Oxford) 47: 1635-1640 (2008). *

• Hashmi S, Zeng QT. Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease. Coron. Artery Dis. 17: 699-706 (2006).

• Hasselberg A, Schon K, Tarkowski A, Lycke N. Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis. Arthritis Rheum. 60: 1672-1682 (2009). *

• Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur. J. Immunol. 39: 2492-2501 (2009). *

• Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, Okuno T, Fujiyama Y, Bamba T. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G1035-G1044 (2002). *

• Haudenschild D, Moseley T, Rose L, Reddi AH. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J. Biol. Chem. 277: 4309-4316 (2002). *

• Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD. Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A(4) to promote the resolution of allergic airway inflammation. Nat. Immunol. 9: 873-879 (2008). *

• Hayashi F, Watanabe M, Nanba T, Inoue N, Akamizu T, Iwatani Y. Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells. Clin. Exp. Immunol. 158: 281-286 (2009). *

• Hazebrouck S, Przybylski-Nicaise L, Ah-Leung S, Adel-Patient K, Corthier G, Langella P, Wal JM. Influence of the route of administration on immunomodulatory properties of bovine beta-lactoglobulin-producing Lactobacillus casei. Vaccine 27: 5800-5805 (2009).

• He B, Gao WD, Song GQ, Wang CC, Yang ML, Liu QS. Expression of 24p3 and interleukin-17A in autoimmune hepatitis. Zhonghua Gan Zang Bing Za Zhi 15: 709-710 (2007).

• He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD, Xu H. IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J. Immunol. Jan 29 [Epub ahead of print] (2010).

• He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. IL-17 and IFN-gamma mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses. J. Immunol. 183: 1463-1470 (2009).

• He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J. Immunol. 177: 6852-6858 (2006). *

• He R, Kim HY, Yoon J, Oyoshi MK, Macginnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J. Allergy Clin. Immunol. 124: 761-770.e1 (2009). *

• He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc. Natl. Acad. Sci. U.S.A. 40: 15817-15822 (2007). *

• He R, Shepard LW, Chen J, Pan ZK, Ye RD. Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23. J. Immunol. 177: 4072-4079 (2006). *

• He W, Fang Z, Wang F, Wu K, Xu Y, Zhou H, Du D, Gao Y, Zhang WN, Niki T, Hirashima M, Yuan J, Chen ZK. Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice. Transplantation 88: 782-790 (2009).

• He Yi LM, Liu ZG, Luo YW, Wang M, Zhang J, Sun EW. Effect of FK506 on cytokine secretion in whole blood. Nan Fang Yi Ke Da Xue Xue Bao 30: 249-251 (2010).

• Hedegaard CJ, Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology 125: 161-169 (2008). *

• Hedrick MN, Lonsdorf AS, Shirakawa AK, Richard Lee CC, Liao F, Singh SP, Zhang HH, Grinberg A, Love PE, Hwang ST, Farber JM. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J. Clin. Invest. 119: 2317-2329 (2009). *

• Heidenreich R, Rocken M, Ghoreschi K. Angiogenesis drives psoriasis pathogenesis. Int. J. Exp. Pathol. 90: 232-248 (2009). *

• Helliwell C. Immunology primer. Immunology news: a new type of T cell is discovered (http://www.acnr.co.uk/JF07/ACNR_JF07_immunology.pdf). ACNR 6: 8-9 (2007). *

• Helmby H. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J. Immunol. 182: 5663-5671 (2009).

• Helmy A, Carpenter KL, Skepper JN, Kirkpatrick PJ, Pickard JD, Hutchinson PJ. Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J. Neurotrauma 26: 549-561 (2009).

• Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J. Immunol. 181: 8576-8584 (2008). *

• Henry T, Kirimanjeswara GS, Ruby T, Jones JW, Peng K, Perret M, Ho L, Sauer JD, Iwakura Y, Metzger DW, Monack DM. Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J. Immunol. Feb 22 [Epub ahead of print] (2010).

• Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4(+) T cell population of rheumatoid arthritis patients. Immunol. Lett. Nov 3 [Epub ahead of print] (2009).

• Herbert DR, Orekov T, Perkins C, Finkelman FD. IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis. J. Immunol. 181: 7214-7220 (2008). *

• Herman S, Kronke G, Schett G. Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends Mol. Med. 14: 245-253 (2008). *

• Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G. The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity 29: 205-216 (2008). *

• Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC. Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis. Genes Immun. 10: 509-516 (2009).

• Higashi T, Hashimoto K, Takagi R, Mizuno Y, Okazaki Y, Tanaka Y, Matsushita S. Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells. Allergol. Int. Feb 25 [Epub ahead of print] (2010).

• Higgins SC, Jarnicki AG, Lavelle EC, Mills KH. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J. Immunol. 177: 7980-7989 (2006). *

• Hildner KM, Schirmacher P, Atreya I, Dittmayer M, Bartsch B, Galle PR, Wirtz S, Neurath MF. Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis. J. Immunol. 178: 3427-3436 (2007). *

• Hillyer P, Larche MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM. Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Rheumatology (Oxford) 48: 1581-1589 (2009). *

• Hinrichs CS, Kaiser A, Paulos CM, Cassard L, Sanchez-Perez L, Heemskerk B, Wrzesinski C, Borman ZA, Muranski P, Restifo NP. Type 17 CD8+ T cells display enhanced anti-tumor immunity. Blood 114: 596-599 (2009). *

• Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y. Interleukin (IL)-17A stimulates IL-8 secretion, COX2 expression, and cell proliferation of endometriotic stromal cells. Endocrinology 149: 1260-1267 (2008). *

• Hirohata S, Shibuya H, Tejima S. Suppressive influences of IFN-alpha on IL-17 expression in human CD4+ T cells. Clin. Immunol. Dec 14 [Epub ahead of print] (2009). *

• Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J. Exp. Med. 204: 41-47 (2007). *

• Hirota K, Martin B, Veldhoen M. Development, regulation and functional capacities of Th17 cells. Semin. Immunopathol. Jan 27 [Epub ahead of print] (2010). *

• Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204: 2803-2812 (2007). *

• Hitchon CA, Alex P, Erdile LB, Frank MB, Dozmorov I, Tang Y, Wong K, Centola M, El-Gabalawy HS. A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis. J. Rheumatol. 31: 2336-2346 (2004).

• Hizawa N, Kawaguchi M, Huang SK, Nishimura M. Role of interleukin-17F in chronic inflammatory and allergic lung disease. Clin. Exp. Allergy 36: 1109-1114 (2006). *

• Ho AW, Gaffen SL. IL-17RC: a partner in IL-17 signaling and beyond. Semin. Immunopathol. Dec 14 [Epub ahead of print] (2009). *

• Ho PP, Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, Benbarak MJ, Chandra PE, Hueber W, Steinman L, Robinson WH. Autoimmunity against fibrinogen mediates inflammatory arthritis in mice. J. Immunol. 184: 379-390 (2010).

• Hoeve MA, Savage ND, Boer TD, Langenberg DM, de Waal Malefyt R, Ottenhoff TH, Verreck FA. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36: 661-670 (2006). *

• Hofstetter H, Gold R, Hartung HP. Th17 cells in MS and experimental autoimmune encephalomyelitis. Int. MS J. 16: 12-18 (2009). *

• Hofstetter HH, Grau C, Buttmann M, Forsthuber TG, Gaupp S, Toyka KV, Gold R. The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells. Cytokine 40: 35-43 (2007).

• Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, Toyka KV, Gold R. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237: 123-130 (2005). *

• Hofstetter HH, Kovalovsky A, Shive CL, Lehmann PV, Forsthuber TG. Neonatal induction of myelin-specific Th1/Th17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood. J. Neuroimmunol. 187: 20-30 (2007).

• Hofstetter HH, Luhder F, Toyka KV, Gold R. IL-17 production by thymocytes upon CD3 stimulation and costimulation with microbial factors. Cytokine 34: 184-197 (2006).

• Hollis-Moffatt JE, Merriman ME, Rodger RA, Rowley KA, Chapman PT, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, O'Donnell JL, Stamp LK, Merriman TR. Evidence for association of an interleukin-23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Ann. Rheum. Dis. 68: 1340-1344 (2009).

• Holm CK, Petersen CC, Hvid M, Petersen L, Paludan SR, Deleuran B, Hokland M. TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells. J. Immunol. 183: 4422-4431 (2009).

• Holtta V, Klemetti P, Sipponen T, Westerholm-Ormio M, Kociubinski G, Salo H, Rasanen L, Kolho KL, Farkkila M, Savilahti E, Vaarala O. IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm. Bowel Dis. 14: 1175-1184 (2008). *

• Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Muller A, deWaal Malefyt R, Deng G, Orozco R, Ruzicka T, Lehmann P, Lebecque S, Caux C, Zlotnik A. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164: 6621-6632 (2000). *

• Homs S, Mansour H, Desvaux D, Diet C, Hazan M, Buchler M, Lebranchu Y, Buob D, Badoual C, Matignon M, Audard V, Lang P, Grimbert P. Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy. Am. J. Transplant. 9: 1230-1236 (2009). *

• Honda T, Aoki Y, Takahashi N, Maekawa T, Nakajima T, Ito H, Tabeta K, Okui T, Kajita K, Domon H, Yamazaki K. Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. Clin. Chim. Acta 395: 137-141 (2008). *

• Hong J, Li H, Chen M, Zang YC, Skinner SM, Killian JM, Zhang JZ. Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis. Int. Immunol. 21: 1329-1340 (2009).

• Honorati MC, Bovara M, Cattini L, Piacentini A, Facchini A. Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage 10: 799-807 (2002).

• Honorati MC, Cattini L, Facchini A. Possible prognostic role of IL-17R in osteosarcoma. J. Cancer Res. Clin. Oncol. 133: 1017-1021 (2007). *

• Honorati MC, Cattini L, Facchini A. VEGF production by osteoarthritic chondrocytes cultured in micromass and stimulated by IL-17 and TNF-alpha. Connect. Tissue Res. 48: 239-245 (2007).

• Honorati MC, Cattini L, Facchini A. IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes. Osteoarthritis Cartilage 12: 683-691 (2004).

• Honorati MC, Meliconi R, Pulsatelli L, Cane S, Frizziero L, Facchini A. High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. Rheumatology (Oxford) 40: 522-527 (2001). *

• Honorati MC, Neri S, Cattini L, Facchini A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage 14: 345-352 (2006).

• Horie I, Abiru N, Nagayama Y, Kuriya G, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K. T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. Endocrinology 150: 5135-5142 (2009). *

• Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y, Tanaka K, Chinen T, Yoshimura A, Nomura S, Kawase I, Hayashi N, Kishimoto T, Naka T. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int. Immunol. 20: 753-762 (2008).

• Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, Toyama Y. Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. J. Immunol. 182: 2093-2101 (2009).

• Horlock C, Stott B, Dyson PJ, Morishita M, Coombes RC, Savage P, Stebbing J. The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer. Br. J. Cancer 100: 1061-1067 (2009). *

• Horwitz DA, Zheng SG, Wang J, Gray JD. Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3(+)CD4(+) Treg. Eur. J. Immunol. 38: 912-915 (2008). *

• Hoshino A, Nagao T, Nagi-Miura N, Ohno N, Yasuhara M, Yamamoto K, Nakayama T, Suzuki K. MPO-ANCA induces IL-17 production by activated neutrophils in vitro via its Fc region- and complement-dependent manner. J. Autoimmun. 31: 79-89 (2008).

• Hosokawa Y, Hosokawa I, Ozaki K, Nakanishi T, Nakae H, Matsuo T. Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts. Cell. Physiol. Biochem. 24: 391-396 (2009). *

• Hou W, Kang HS, Kim BS. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J. Exp. Med. 206: 313-328 (2009). *

• Hoyer KK, Kuswanto WF, Gallo E, Abbas AK. Distinct roles of helper T cell subsets in a systemic autoimmune disease. Blood 113: 389-395 (2009). *

• Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, Le TV, Lorenz RG, Xu H, Kolls JK, Carter RH, Chaplin DD, Williams RW, Mountz JD. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9: 166-175 (2008). *

• Hsu W, Zhang W, Tsuneyama K, Moritoki Y, Ridgway WM, Ansari AA, Coppel RL, Lian ZX, Mackay I, Gershwin ME. Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. Hepatology 49: 133-140 (2009). *

• Hu L, Edamatsu H, Takenaka N, Ikuta S, Kataoka T. Crucial role of phospholipase Cvarepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity. J. Immunol. 184: 993-1002 (2010).

• Hu SM, Luo YL, Lai WY. Effects of dexamethasone on expression of Th17 transcription factor RORgammat mRNA in experimental asthma mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25: 1115-1118 (2009).

• Hu SM, Luo YL, Lai WY, Chen PF. Effects of dexamethasone on intracellular expression of Th17 cytokine interleukin 17 in asthmatic mice. Nan Fang Yi Ke Da Xue Xue Bao 29: 1185-1188 (2009).

• Hu T, Takamoto M, Hida S, Tagawa YI, Sugane K. IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice. Immunol. Lett. 127: 55-59 (2009).

• Huan J, Kaler LJ, Mooney JL, Subramanian S, Hopke C, Vandenbark AA, Rosloniec EF, Burrows GG, Offner H. MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis. J. Immunol. 180: 1249-1257 (2008). *

• Huang B, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, Feng ZH. SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood 112: 1269-1279 (2008). *

• Huang H, Kim HJ, Chang EJ, Lee ZH, Hwang SJ, Kim HM, Lee Y, Kim HH. IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. Cell Death Differ. 16: 1332-1343 (2009). *

• Huang J, Zhao JJ, Li J, Li Z. Detection of Th17 cells in splenocytes of BALB/c mouse. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25: 490-492 (2009).

• Huang MC, Liao JJ, Bonasera S, Longo DL, Goetzl EJ. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 22: 2142-2150 (2008). *

• Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ. Human CD4-8- T cells are a distinctive immunoregulatory subset. FASEB J. Feb 12 [Epub ahead of print] (2010). *

• Huang MC, Watson SR, Liao JJ, Goetzl EJ. Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. J. Immunol. 178: 6806-6813 (2007). *

• Huang SH, Frydas S, Conti P, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R, Papadopoulou N, Donelan J, Madhappan B, Theoharides TC, De Lutiis MA, Riccioni G, Sabatino G. Interleukin-17: a revisited study. Int. J. Immunopathol. Pharmacol. 17: 1-4 (2004).

• Huang SH, Frydas S, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R, Madhappan B, Papadopoulou N, Verna N, De Lutiis MA, Iezzi T, Riccioni G, Theoharides TC, Conti P. Interleukin-17 and the interleukin-17 family member network. Allergy Asthma Proc. 25: 17-21 (2004).

• Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 190: 624-631 (2004). *

• Huang Y, Wu W, Wang Y. Expression or secretion of IL-17 in the peripheral blood mononuclear cells from patients with dilated cardiomyopathy. Acta Cardiol. 64: 201-205 (2009).

• Huang Z, Xie H, Wang R, Sun Z. Retinoid-related orphan receptor gammat is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opin. Ther. Targets 11: 737-743 (2007).

• Huber M, Brustle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Low E, Lohoff M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc. Natl. Acad. Sci. U.S.A. 105: 20846-20851 (2008). *

• Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hunig T, Mittrucker HW, Brustle A, Kamradt T, Lohoff M. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur. J. Immunol. 39: 1716-1725 (2009). *

• Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, Mao H, Nuovo G, Yu J, Caligiuri MA. Stage three immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22. Blood 113: 4008-4010 (2009). *

• Hung LY, Velichko S, Huang F, Thai P, Wu R. Regulation of airway innate and adaptive immune responses: the IL-17 paradigm. Crit. Rev. Immunol. 28: 269-279 (2008).

• Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5: 521-531 (2005). *

• Hunter CA. Act1-ivating IL-17 inflammation. Nat. Immunol. 8: 232-234 (2007). *

• Hunter CA, Kastelein R. New paradigms in inflammation: where to next? Immunol. Rev. 226: 6-9 (2008). *

• Huppert J, Closhen D, Croxford A, White R, Kulig P, Pietrowski E, Bechmann I, Becher B, Luhmann HJ, Waisman A, Kuhlmann CR. Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J. Nov 25 [Epub ahead of print] (2009). *

• Hurst SD, Muchamuel T, Gorman DM, Gilbert JM, Clifford T, Kwan S, Menon S, Seymour B, Jackson C, Kung TT, Brieland JK, Zurawski SM, Chapman RW, Zurawski G, Coffman RL. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol. 169: 443-453 (2002). *

• Hussein MR, Fathi NA, El-Din AM, Hassan HI, Abdullah F, Al-Hakeem E, Backer EA. Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations. Pathol. Oncol. Res. 14: 321-328 (2008).

• Hvid H, Teige I, Kvist PH, Svensson L, Kemp K. TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. Int. Immunol. 20: 1097-1106 (2008).

• Hwang JH, Lee MJ, Seok OS, Paek YC, Cho GJ, Seol HJ, Lee JK, Oh MJ. Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies. Cytokine Oct 9 [Epub ahead of print] (2009).

• Hwang SY, Kim HY. Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. Mol. Cells 19: 180-184 (2005). *

• Hwang SY, Kim JY, Kim KW, Park MK, Moon Y, Kim WU, Kim HY. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. Arthritis Res. Ther. 6: R120-R128 (2004). *

• Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20: 5332-5341 (2001). *

• Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Moroy T, Yoshimura A. Gfi1 negatively regulates Th17 differentiation by inhibiting RORgammat activity. Int. Immunol. 21: 881-889 (2009). *

• Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgamma t-mediated IL-17A mRNA transcription through direct interaction with RORgamma t. J. Biol. Chem. 283: 17003-17008 (2008). *

• Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 876-881 (2009). *

• Ifergan I, Kebir H, Bernard M, Wosik K, Dodelet-Devillers A, Cayrol R, Arbour N, Prat A. The blood brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 131: 785-799 (2008).

• Iguchi T, Kawata A, Watanabe T, Mazumder TK, Tanabe S. Fermented barley extract suppresses the development of atopic dermatitis-like skin lesions in NC/Nga mice, probably by inhibiting inflammatory cytokines. Biosci. Biotechnol. Biochem. 73: 489-493 (2009). *

• Ilic V, Krstic A, Katic-Radivojevic S, Jovcic G, Milenkovic P, Bugarski D. Syphacia obvelata modifies mitogen-activated protein kinases and nitric oxide synthases expression in murine bone marrow cells. Parasitol. Int. Nov 7 [Epub ahead of print] (2009).

• Illes Z, Safrany E, Peterfalvi A, Magyari L, Farago B, Pozsonyi E, Rozsa C, Komoly S, Melegh B. 3'UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis. Neurosci. Lett. 431: 36-38 (2008). *

• Imamura M, Okunishi K, Ohtsu H, Nakagome K, Harada H, Tanaka R, Yamamoto K, Dohi M. Pravastatin attenuates allergic airway inflammation by suppressing antigen-sensitization, IL-17 production, and antigen-presentation in the lung. Thorax 64: 44-49 (2009).

• Imler TJ Jr, Petro TM. Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17(+)IL-10(+) T cells, CD4(-) IFN-gamma(+) cells, and decreased macrophage IL-6 expression. Int. Immunopharmacol. 9: 134-143 (2009).

• Incorvaia C, Frati F, Puccinelli P, Marcucci F, Di Cara G, Sensi L, Scurati S, Yacoub MR, Moingeon P. Effects of sublingual immunotherapy on allergic inflammation. Inflamm. Allergy Drug Targets 7: 167-172 (2008).

• Incorvaia C, Frati F, Verna N, D'Alo S, Motolese A, Pucci S. Allergy and the skin. Clin. Exp. Immunol. 153 Suppl. 1: 27-29 (2008). *

• Infante-Duarte C, Horton HF, Byrne MC, Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 165: 6107-6115 (2000). *

• Ingram RJ, Isaacs JD, Kaur G, Lowther DE, Reynolds CJ, Boyton RJ, Collinge J, Jackson GS, Altmann DM. A role of cellular prion protein in programming T-cell cytokine responses in disease. FASEB J. 23: 1672-1684 (2009). *

• Inoue H, Takayanagi H. Rheumatoid arthritis in the context of bone and cartilage. Molecular mechanism of bone destruction. Clin. Calcium 19: 339-346 (2009).

• Inozume T, Hanada K, Wang QJ, Yang JC. IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells. J. Immunother. 32: 109-117 (2009).

• Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321: 408-411 (2008). *

• Irmler IM, Gajda M, Brauer R. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J. Immunol. 179: 6228-6236 (2007). *

• Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30: 108-119 (2009). *

• Ishigame H, Nakajima A, Saijo S, Komiyama Y, Nambu A, Matsuki T, Nakae S, Horai R, Kakuta S, Iwakura Y. The role of TNFalpha and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice. Ernst Schering Res. Found. Workshop 56: 129-153 (2006).

• Ishizu T, Osoegawa M, Mei FJ, Kikuchi H, Tanaka M, Takakura Y, Minohara M, Murai H, Mihara F, Taniwaki T, Kira J. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128: 988-1002 (2005). *

• Islander U, Andersson A, Lindberg E, Adlerberth I, Wold AE, Rudin A. Superantigenic Staphylococcus aureus stimulate production of IL-17 from memory but not naive T cells. Infect. Immun. 78: 381-386 (2010). *

• Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, Nikaido T, Saito S. A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour. J. Reprod. Immunol. Dec 5 [Epub ahead of print] (2009).

• Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, Imanishi J, Iwakura Y, Okanoue T, Yoshikawa T, Kataoka K, Mazda O. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem. Biophys. Res. Commun. 377: 12-16 (2008). *

• Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T. Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum. 60: 2294-2303 (2009). *

• Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP. IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J. Clin. Immunol. Feb 4 [Epub ahead of print] (2010). *

• Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485-498 (2009). *

• Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4: 337-349 (2008). *

• Ivanov II, Littman DR. Segmented filamentous bacteria take the stage. Mucosal Immunol. Feb 10 [Epub ahead of print] (2010).

• Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17(+) T helper cells. Cell 126: 1121-1133 (2006). *

• Ivanov II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 19: 409-417 (2007). *

• Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am. J. Respir. Cell. Mol. Biol. 36: 442-451 (2007). *

• Ivanov S, Linden A. Interleukin-17 as a drug target in human disease. Trends Pharmacol. Sci. 30: 95-103 (2009). *

• Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J. Clin. Invest. 116: 1218-1222 (2006). *

• Iwakura Y, Nakae S, Saijo S, Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol. Rev. 226: 57-79 (2008). *

• Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. J. Immunol. 179: 1449-1457 (2007). *

• Iwanami K, Matsumoto I, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T. Arthritogenic T cell epitope in glucose-6-phosphate isomerase (GPI)-induced arthritis. Arthritis Res. Ther. 10: R130 (2008). *

• Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum. 58: 754-763 (2008). *

• Iwanami K, Matsumoto I, Yoshiga Y, Inoue A, Kondo Y, Yamamoto K, Tanaka Y, Minami R, Hayashi T, Goto D, Ito S, Nishimura Y, Sumida T. Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide. Arthritis Res. Ther. 11: R167 (2009). *

• Iwata D, Kitamura M, Kitaichi N, Saito Y, Kon S, Namba K, Morimoto J, Ebihara A, Kitamei H, Yoshida K, Ishida S, Ohno S, Uede T, Onoe K, Iwabuchi K. Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA. Exp. Eye Res. 90: 41-48 (2010). *

• Iyoda M, Shibata T, Kawaguchi M, Hizawa N, Yamaoka T, Kokubu F, Akizawa T. IL-17A and IL-17F stimulate chemokines via MAPK pathways (ERK1/2 and p38 but not JNK) in mouse cultured mesangial cells: synergy with TNF-alpha and IL-1beta. Am. J. Physiol. Renal Physiol. Dec 30 [Epub ahead of print] (2009). *

• Izcue A, Hue S, Buonocore S, Arancibia-Carcamo CV, Ahern PP, Iwakura Y, Maloy KJ, Powrie F. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity 28: 559-570 (2008). *

• Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN, Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand mixed 2328 bice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J. Immunol. 182: 2532-2541 (2009).

• Jacobs JP, Wu HJ, Benoist C, Mathis D. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc. Natl. Acad. Sci. U.S.A. Dec 2 [Epub ahead of print] (2009). *

• Jafarzadeh A, Esmaeeli-Nadimi A, Nough H, Nemati M, Rezayati MT. Serum levels of interleukin (IL)-13, IL-17 and IL-18 in patients with ischemic heart disease. Anadolu. Kardiyol. Derg. 9: 75-83 (2009).

• Jafarzadeh A, Mirzaee V, Ahmad-Beygi H, Nemati M, Rezayati MT. Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. J. Dig. Dis. 10: 107-112 (2009). *

• Jaffar Z, Ferrini ME, Girtsman TA, Roberts K. Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways. Eur. J. Immunol. 39: 3307-3314 (2009). *

• Jaffar Z, Ferrini ME, Herritt LA, Roberts K. Cutting edge: lung mucosal Th17-mediated responses induce polymeric Ig receptor expression by the airway epithelium and elevate secretory IgA levels. J. Immunol. 182: 4507-4511 (2009).

• Jager A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183: 7169-7177 (2009).

• Jain R, Tartar DM, Gregg RK, Divekar RD, Bell JJ, Lee HH, Yu P, Ellis JS, Hoeman CM, Franklin CL, Zaghouani H. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J. Exp. Med. 205: 207-218 (2008). *

• Jain V, Armah HB, Tongren JE, Ned RM, Wilson NO, Crawford S, Joel PK, Singh MP, Nagpal AC, Dash AP, Udhayakumar V, Singh N, Stiles JK. Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar. J. 7: 83 (2008).

• Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum. 58: 2307-2317 (2008). *

• Jane-Wit D, Altuntas CZ, Monti J, Johnson JM, Forsthuber TG, Tuohy VK. Sex-defined T-cell responses to cardiac self determine differential outcomes of murine dilated cardiomyopathy. Am. J. Pathol. 172: 11-21 (2008). *

• Jang WC, Nam YH, Ahn YC, Lee SH, Park SH, Choe JY, Lee SS, Kim SK. Interleukin-17F gene polymorphisms in Korean patients with Behcet's disease. Rheumatol. Int. 29: 173-178 (2008). *

• Janke M, Peine M, Nass A, Morawietz L, Hamann A, Scheffold A. In vitro-induced Th17 cells fail to induce inflammation in vivo and show an impaired migration into inflamed sites. Eur. J. Immunol. Jan 25 [Epub ahead of print] (2010). *

• Jarry A, Bossard C, Bou-Hanna C, Masson D, Espaze E, Denis MG, Laboisse CL. Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants. J. Clin. Invest. 118: 1132-1142 (2008). *

• Jayaraman S, Patel T, Patel V, Ajani S, Garza R, Jayaraman A, Kwon S, Singh R, Rondelli D, Prabhakar BS, Holterman M. Transfusion of nonobese diabetic mice with allogeneic newborn blood ameliorates autoimmune diabetes and modifies the expression of selected immune response genes. J. Immunol. Feb 17 [Epub ahead of print] (2010).

• Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, Walker LS, Lammas DA, Raza K, Sansom DM. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 183: 5458-5467 (2009).

• Jensen KD, Chien YH. Thymic maturation determines gammadelta T cell function, but not their antigen specificities. Curr. Opin. Immunol. 21: 140-145 (2009).

• Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 29: 90-100 (2008). *

• Jiang G, Ke Y, Sun D, Han G, Kaplan HJ, Shao H. Reactivation of uveitogenic T cells by retinal astrocytes derived from experimental autoimmune uveitis-prone B10RIII mice. Invest. Ophthalmol. Vis. Sci. 49: 282-289 (2008). *

• Jiang G, Ke Y, Sun D, Wang Y, Kaplan HJ, Shao H. Regulatory role of TLR ligands on the activation of autoreactive T cells by retinal astrocytes. Invest. Ophthalmol. Vis. Sci. 50: 4769-4776 (2009).

• Jiang HR, Al Rasebi Z, Mensah-Brown E, Shahin A, Xu D, Goodyear CS, Fukada SY, Liu FT, Liew FY, Lukic ML. Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis. J. Immunol. 182: 1167-1173 (2009).

• Jiang S, Liu X, Luo L, Qu B, Huang X, Xu L, Lin Y, Ye S, Liu Y. Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease. Br. J. Ophthalmol. Nov 11 [Epub ahead of print] (2009).

• Jiang X, Shen C, Yu H, Karunakaran KP, Brunham RC. Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. Immunology Sep 11 [Epub ahead of print] (2009). *

• Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A. MOG(35-55) i.v suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK/STAT pathways. Eur. J. Immunol. 39: 789-799 (2009). *

• Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi KI. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J. Neuroinflammation 5: 23 (2008).

• Johansen C, Usher PA, Kjellerup RB, Lundsgaard D, Iversen L, Kragballe K. Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br. J. Dermatol. 160: 319-324 (2009). *

• Johnson AJ, Nelson MH, Bird MD, Chu CF, Milligan GN. Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection. J. Reprod. Immunol. Nov 24 [Epub ahead of print] (2009).

• Johnson E, Forland DT, Saetre L, Bernardshaw SV, Lyberg T, Hetland G. Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo. Scand. J. Immunol. 69: 242-250 (2009). *

• Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J. Immunol. 183: 5251-5260 (2009).

• Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, van den Bersselaar LA, Oppers-Walgreen B, Koenders MI, van den Berg WB. T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17. Arthritis Rheum. 58: 98-108 (2007). *

• Joosten LA, Radstake TR, Lubberts E, van den Bersselaar LA, van Riel PL, van Lent PL, Barrera P, van den Berg WB. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 48: 339-347 (2003). *

• Jordan JM, Woods ME, Olano J, Walker DH. Absence of TLR4 signaling in C3H/HeJ mice predisposes to overwhelming rickettsial infection and decreased protective Th1 responses. Infect. Immun. 76: 3717-3724 (2008). *

• Jorde R, Sneve M, Torjesen PA, Figenschau Y, Goransson LG, Omdal R. No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects. Cytokine Jan 30 [Epub ahead of print] (2010).

• Joshi AD, Fong DJ, Oak SR, Trujillo G, Flaherty KR, Martinez FJ, Hogaboam CM. IL-17 mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Am. J. Respir. Crit. Care Med. 179: 705-716 (2009). *

• Joshi AD, Schaller MA, Lukacs NW, Kunkel SL, Hogaboam CM. TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung. Eur. J. Immunol. 38: 3436-3449 (2008). *

• Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J. Immunol. 160: 3513-3521 (1998). *

• Jovanovic DV, Di Battista JA, Martel-Pelletier J, Reboul P, He Y, Jolicoeur FC, Pelletier JP. Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages. J. Rheumatol. 28: 712-718 (2001).

• Jovanovic DV, Martel-Pelletier J, Di Battista JA, Mineau F, Jolicoeur FC, Benderdour M, Pelletier JP. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum. 43: 1134-1144 (2000). *

• Jovcic G, Bugarski D, Krstic A, Vlaski M, Petakov M, Mojsilovic S, Stojanovic N, Milenkovic P. The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen. Physiol. Res. 56: 331-339 (2007). *

• Ju JH, Cho ML, Moon YM, Oh HJ, Park JS, Jhun JY, Min SY, Cho YG, Park KS, Yoon CH, Min JK, Park SH, Sung YC, Kim HY. IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model. J. Immunol. 181: 1507-1518 (2008). *

• Juarranz Y, Abad C, Martinez C, Arranz A, Gutierrez-Canas I, Rosignoli F, Gomariz RP, Leceta J. Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res. Ther. 7: R1034-R1045 (2005). *

• Jung JS, Park BL, Cheong HS, Bae JS, Kim JH, Chang HS, Rhym T, Park JS, Jang AS, Lee YM, Kim KU, Uh ST, Na JO, Kim YH, Park CS, Shin HD. Association of IL17RB gene polymorphism with asthma. Chest 135: 1173-1180 (2009). *

• Jung MY, Kim SH, Cho D, Kim TS. Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice. Oncol. Rep. 22: 1141-1147 (2009).

• Jung S, Park YK, Lee H, Shin JH, Lee GR, Park SH. TGF-beta-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses. Exp. Mol. Med. Feb 11 [Epub ahead of print] (2010).

• Jung S, Shin HS, Hong C, Lee H, Park YK, Shin JH, Hong S, Lee GR, Park SH. Natural killer T cells promote collagen-induced arthritis by IL17 production in DBA/1 mice. Biochem. Biophys. Res. Commun. 390: 399-403 (2009). *

• Jung YO, Min SY, Cho ML, Park MJ, Jeon JY, Lee JS, Oh HJ, Kang CM, Park HS, Park KS, Cho SG, Park SH, Kim HY. CD8alpha+ dendritic cells enhance the antigen-specific CD4+ T-cell response and accelerate development of collagen-induced arthritis. Immunol. Lett. 111: 76-83 (2007).

• Jurisic V, Stojacic-Djenic S, Colovic N, Konjevic G. The role of cytokine in regulation of the natural killer cell activity. Srp. Arh. Celok. Lek. 136: 423-429 (2008).

• Juszczak M, Glabinski A. Th17 cells in the pathogenesis of multiple sclerosis. Postepy. Hig. Med. Dosw. (Online) 63: 492-501 (2009).

• Jyonouchi H, Geng L, Cushing-Ruby A, Monteiro IM. Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to Candida, a luminal antigen. Pediatr. Allergy Immunol. Aug 27 [Epub ahead of print] (2009). *

• Kabelitz D, Schreiber S. Autoimmunity. Physiological control mechanisms and pathways to autoimmune disease. Internist (Berl.) 50: 267-275 (2009).

• Kader M, Bixler S, Piatak M, Lifson J, Mattapallil JJ. Anti-retroviral therapy fails to restore the severe Th-17:Tc-17 imbalance observed in peripheral blood during simian immunodeficiency virus infection. J. Med. Primatol. 38 Suppl. 1: 32-38 (2009).

• Kader M, Bixler S, Roederer M, Veazey R, Mattapallil JJ. CD4 T cell subsets in the mucosa are CD28Ki-67HLA-DRCD69 but show differential infection based on alpha4beta7 receptor expression during acute SIV infection. J. Med. Primatol. 38 Suppl. 1: 24-31 (2009).

• Kagami S, Rizzo HL, Lee JJ, Koguchi Y, Blauvelt A. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J. Invest. Dermatol. Dec 24 [Epub ahead of print] (2009). *

• Kagami SI, Owada T, Kanari H, Saito Y, Suto A, Ikeda K, Hirose K, Watanabe N, Iwamoto I, Nakajima H. Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. Int. Immunol. 21: 679-689 (2009).

• Kageyama Y, Ichikawa T, Nagafusa T, Torikai E, Shimazu M, Nagano A. Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis. Rheumatol. Int. 28: 137-143 (2007). *

• Kageyama Y, Kobayashi H, Kato N. Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis. Mod. Rheumatol. 19: 657-662 (2009). *

• Kageyama Y, Takahashi M, Torikai E, Suzuki M, Ichikawa T, Nagafusa T, Koide Y, Nagano A. Treatment with anti-TNF-alpha antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis. Clin. Rheumatol. 26: 505-509 (2007). *

• Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, Tahara H. Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12. J. Immunol. 178: 7571-7580 (2007). *

• Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T. TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease. Inflamm. Bowel Dis. Oct 15 [Epub ahead of print] (2009). *

• Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume MT, Sugita A, Koganei K, Akagawa KS, Hibi T. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J. Clin. Invest. 118: 2269-2280 (2008). *

• Kaminska M, Foley S, Maghni K, Storness-Bliss C, Coxson H, Ghezzo H, Lemiere C, Olivenstein R, Ernst P, Hamid Q, Martin J. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J. Allergy Clin. Immunol. 124: 45-51.e1-e4 (2009). *

• Kamphuis S, Hrafnkelsdottir K, Klein MR, de Jager W, Haverkamp MH, van Bilsen JH, Albani S, Kuis W, Wauben MH, Prakken BJ. Novel self-epitopes derived from aggrecan, fibrillin and matrix-metalloproteinase 3 drive distinct autoreactive T cell responses in juvenile idiopathic arthritis and in health. Arthritis Res. Ther. 8: R178 (2006). *

• Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T. Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr. Opin. Gastroenterol. 25: 306-313 (2009). *

• Kanda N, Koike S, Watanabe S. IL-17 suppresses TNF-alpha-induced CCL27 production through induction of COX-2 in human keratinocytes. J. Allergy Clin. Immunol. 116: 1144-1150 (2005). *

• Kanda N, Shibata S, Tada Y, Nashiro K, Tamaki K, Watanabe S. Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. Eur. J. Immunol. 39: 996-1006 (2009). *

• Kano SI, Sato K, Morishita Y, Vollstedt S, Kim S, Bishop K, Honda K, Kubo M, Taniguchi T. The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. Nat. Immunol. 9: 34-41 (2008). *

• Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol. 173: 3482-3491 (2004). *

• Kao CY, Kim C, Huang F, Wu R. Requirements for two proximal NF-kappa B binding sites and Ikappa B-zeta in IL-17A-induced human beta -defensin 2 expression by conducting airway Epithelium. J. Biol. Chem. 283: 15309-15318 (2008). *

• Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology Nov 17 [Epub ahead of print] (2009). *

• Kapessidou P, Poulin L, Dumoutier L, Goldman M, Renauld JC, Braun MY. Interleukin-22 deficiency accelerates the rejection of full major histocompatibility complex-disparate heart allografts. Transplant. Proc. 40: 1593-1597 (2008). *

• Kapil P, Atkinson R, Ramakrishna C, Cua DJ, Bergmann CC, Stohlman SA. IL-12, but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control. J. Virol. 83: 5978-5986 (2009). *

• Kappel LW, Goldberg GL, King CG, Suh DY, Smith OM, Ligh C, Holland AM, Grubin J, Mark NM, Liu C, Iwakura Y, Heller G, van den Brink MR. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 113: 945-952 (2009). *

• Karwot R, Maxeiner JH, Schmitt S, Scholtes P, Hausding M, Lehr HA, Glimcher LH, Finotto S. Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model. J. Allergy Clin. Immunol. 121: 992-999.e6 (2008). *

• Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S. Anti-PD-1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J. Immunol. Feb 5 [Epub ahead of print] (2010).

• Kaser A, Blumberg RS. Adaptive immunity in inflammatory bowel disease: state of the art. Curr. Opin. Gastroenterol. 24: 455-461 (2008). *

• Kaser A, Tilg H. Novel therapeutic targets in the treatment of IBD. Expert Opin. Ther. Targets 12: 553-563 (2008).

• Kasper DL. A paradigm for commensalism: the role of a specific microbial polysaccharide in health and disease. Nestle Nutr. Workshop Ser. Pediatr. Program 64: 1-10 (2009).

• Kasper LH, Shoemaker J. Multiple sclerosis immunology: the healthy immune system vs the MS immune system. Neurology 74 Suppl. 1: S2-S8 (2010).

• Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am. J. Pathol. 175: 1167-1177 (2009). *

• Kattah MG, Wong MT, Yocum MD, Utz PJ. Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells. Arthritis Rheum. 58: 1619-1629 (2008). *

• Katz Y, Nadiv O, Beer Y. Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts: a possible role as a "fine-tuning cytokine" in inflammation processes. Arthritis Rheum. 44: 2176-2184 (2001). *

• Katz Y, Nadiv O, Rapoport MJ, Loos M. IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts. Clin. Exp. Immunol. 120: 22-29 (2000). *

• Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N. Role of interleukin-17F in asthma. Inflamm. Allergy Drug Targets 8: 383-389 (2009).

• Kawaguchi M, Kokubu F, Kuga H, Matsukura S, Hoshino H, Ieki K, Imai T, Adachi M, Huang SK. Modulation of bronchial epithelial cells by IL-17. J. Allergy Clin. Immunol. 108: 804-809 (2001). *

• Kawaguchi M, Takahashi D, Hizawa N, Suzuki S, Matsukura S, Kokubu F, Maeda Y, Fukui Y, Konno S, Huang SK, Nishimura M, Adachi M. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J. Allergy Clin. Immunol. 117: 795-801 (2006). *

• Kawakami Y, Tomimori Y, Yumoto K, Hasegawa S, Ando T, Tagaya Y, Crotty S, Kawakami T. Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J. Exp. Med. 206: 1219-1225 (2009). *

• Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A. Production and functions of IL-17 in microglia. J. Neuroimmunol. 194: 54-61 (2008).

• Kawashima M, Miossec P. Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression. Arthritis Rheum. 48: 631-637 (2003). *

• Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Kamachi M, Yamasaki S, Nakamura H, Tsurumoto T, Kono M, Shindo H, Ida H, Origuchi T, Eguchi K. Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs. J. Rheumatol. 36: 2397-2402 (2009).

• Ke Y, Jiang G, Sun D, Kaplan HJ, Shao H. Retinal astrocytes respond to IL-17 differently than retinal pigment epithelial cells. J. Leukoc. Biol. 86: 1377-1384 (2009). *

• Ke Y, Liu K, Huang GQ, Cui Y, Kaplan HJ, Shao H, Sun D. Anti-inflammatory role of IL-17 in experimental autoimmune uveitis. J. Immunol. 182: 3183-3190 (2009).

• Kebir H, Ifergan I, Alvarez JI, Bernard M, Poirier J, Arbour N, Duquette P, Prat A. Preferential recruitment of interferon-gamma-expressing T(H)17 cells in multiple sclerosis. Ann. Neurol. 66: 390-402 (2009).

• Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. Human T(H)17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13: 1173-1175 (2007). *

• Kehlen A, Pachnio A, Thiele K, Langner J. Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6. Arthritis Res. Ther. 5: R186-R192 (2003). *

• Kehlen A, Thiele K, Riemann D, Langner J. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Clin. Exp. Immunol. 127: 539-546 (2002). *

• Kehlen A, Thiele K, Riemann D, Rainov N, Langner J. Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines. J. Neuroimmunol. 101: 1-6 (1999).

• Keino H, Watanabe T, Sato Y, Niikura M, Wada Y, Okada AA. Therapeutic effect of a potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res. Ther. 10: R122 (2008). *

• Keino H, Watanabe T, Sato Y, Okada AA Dr. Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis. Br. J. Ophthalmol. Dec 3 [Epub ahead of print] (2009).

• Kelchtermans H, Schurgers E, Geboes L, Mitera T, Van Damme J, van Snick J, Uyttenhove C, Matthys P. Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res. Ther. 11: R122 (2009). *

• Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect. Immun. 73: 617-621 (2005). *

• Kennedy J, Rossi DL, Zurawski SM, Vega F Jr, Kastelein RA, Wagner JL, Hannum CH, Zlotnik A. Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. J. Interferon Cytokine Res. 16: 611-617 (1996).

• Kerr EC, Raveney BJ, Copland DA, Dick AD, Nicholson LB. Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J. Autoimmun. 31: 354-361 (2008).

• Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. IL-23 and IL-17 in the establishment of protective pulmonary CD4(+) T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol. 8: 369-377 (2007). *

• Khader SA, Gaffen SL, Kolls JK. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol. 2: 403-411 (2009).

• Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J. Immunol. 175: 788-795 (2005). *

• Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G. Helicobacter pylori stimulates dendritic cells to induce IL-17 expression from CD4+ T lymphocytes. Infect. Immun. Nov 16 [Epub ahead of print] (2009). *

• Khatib SA, Keles S, Garcia-Lloret M, Karakoc-Aydiner E, Reisli I, Artac H, Camcioglu Y, Cokugras H, Somer A, Kutukculer N, Yilmaz M, Ikinciogullari A, Yegin O, Yuksek M, Genel F, Kucukosmanoglu E, Baki A, Bahceciler NN, Rambhatla A, Nickerson DW, et al. Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome. J. Allergy Clin. Immunol. 124: 342-348.e1-e5 (2009). *

• Kidoya H, Umemura M, Kawabe T, Matsuzaki G, Yahagi A, Imamura R, Suda T. Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production. J. Immunol. 175: 8024-8031 (2005). *

• Kihara Y, Matsushita T, Kita Y, Uematsu S, Akira S, Kira JI, Ishii S, Shimizu T. Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. Dec 7 [Epub ahead of print] (2009). *

• Kikly K, Liu L, Na S, Sedgwick JD. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr. Opin. Immunol. 18: 670-675 (2006). *

• Kim B, Sarangi PP, Azkur AK, Kaistha SD, Rouse BT. Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses. Microbes Infect. 10: 302-312 (2008). *

• Kim CH. Migration and function of Th17 cells. Inflamm. Allergy Drug Targets 8: 221-228 (2009).

• Kim CJ, Kovacs-Nolan JA, Yang C, Archbold T, Fan MZ, Mine Y. L-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. J. Nutr. Biochem. May 8 [Epub ahead of print] (2009). *

• Kim EY, Chi HH, Bouziane M, Gaur A, Moudgil KD. Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma. Clin. Immunol. 127: 98-106 (2008). *

• Kim GT, Cho ML, Park YE, Yoo WH, Kim JH, Oh HJ, Kim DS, Baek SH, Lee SH, Lee JH, Kim HY, Kim SI. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Clin. Rheumatol. Dec 2 [Epub ahead of print] (2009). *

• Kim HJ, Jung CG, Jensen MA, Dukala D, Soliven B. Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy. J. Immunol. 181: 8753-8760 (2008). *

• Kim HR, Cho ML, Kim KW, Juhn JY, Hwang SY, Yoon CH, Park SH, Lee SH, Kim HY. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways. Rheumatology (Oxford) 46: 57-64 (2007). *

• Kim HR, Kim HS, Park MK, Cho ML, Lee SH, Kim HY. The clinical role of IL-23p19 in patients with rheumatoid arthritis. Scand. J. Rheumatol. 36: 259-264 (2007). *

• Kim KW, Cho ML, Kim HR, Ju JH, Park MK, Oh HJ, Kim JS, Park SH, Lee SH, Kim HY. Up-regulation of stromal cell-derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: role of interleukin-17 and CD40L-CD40 interaction. Arthritis Rheum. 56: 1076-1086 (2007). *

• Kim KW, Cho ML, Lee SH, Oh HJ, Kang CM, Ju JH, Min SY, Cho YG, Park SH, Kim HY. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol. Lett. 110: 54-64 (2007).

• Kim KW, Cho ML, Oh HJ, Kim HR, Kang CM, Heo YM, Lee SH, Kim HY. TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis. Immunol. Lett. 124: 9-17 (2009).

• Kim KW, Cho ML, Park MK, Yoon CH, Park SH, Lee SH, Kim HY. Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis. Arthritis Res. Ther. 7: R139-R148 (2005). *

• Kim MR, Manoukian R, Yeh R, Silbiger SM, Danilenko DM, Scully S, Sun J, DeRose ML, Stolina M, Chang D, Van GY, Clarkin K, Nguyen HQ, Yu YB, Jing S, Senaldi G, Elliott G, Medlock ES. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood 100: 2330-2340 (2002). *

• Kim S, Yang JY, Lee K, Oh KH, Gi M, Kim JM, Paik DJ, Hong S, Youn J. Bacillus subtilis-specific poly-gamma-glutamic acid regulates development pathways of naive CD4+ T cells through antigen-presenting cell-dependent and -independent mechanisms. Int. Immunol. 21: 977-990 (2009).

• Kim SC, Tonkonogy SL, Karrasch T, Jobin C, Sartor RB. Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm. Bowel Dis. 13: 1457-1466 (2007). *

• Kim SR, Lee KS, Park SJ, Min KH, Lee KY, Choe YH, Lee YR, Kim JS, Hong SJ, Lee YC. PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease. J. Immunol. 179: 6820-6829 (2007). *

• Kim YG, Lee CK, Oh JS, Kim SH, Kim KA, Yoo B. Effect of interleukin-32gamma on differentiation of osteoclasts from CD14+ monocytes. Arthritis Rheum. 62: 515-523 (2010). *

• Kim YS, Hong SW, Choi JP, Shin TS, Moon HG, Choi EJ, Jeon SG, Oh SY, Gho YS, Zhu Z, Kim YK. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J. Immunol. 183: 5113-5120 (2009).

• Kimura A, Naka T, Kishimoto T. IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc. Natl. Acad. Sci. U.S.A. 104: 12099-12104 (2007). *

• Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc. Natl. Acad. Sci. U.S.A. 105: 9721-9726 (2008). *

• King MJ, Hanania NA. Asthma in the elderly: current knowledge and future directions. Curr. Opin. Pulm. Med. 16: 55-59 (2010).

• Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol. 123: 179-186 (2009). *

• Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118: 1001-1011 (2000). *

• Kira J. Multiple sclerosis. Rinsho Shinkeigaku 45: 912-915 (2005).

• Kira J. Recent advances of multiple sclerosis research in Japan. Rinsho Shinkeigaku 49: 549-559 (2009).

• Kirjavainen PV, Pautler S, Baroja ML, Anukam K, Crowley K, Carter K, Reid G. Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections. Clin. Vaccine Immunol. 16: 29-36 (2009). *

• Kirkham BW, Lassere MN, Edmonds JP, Juhasz KM, Bird PA, Lee CS, Shnier R, Portek IJ. Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). Arthritis Rheum. 54: 1122-1131 (2006). *

• Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med. Feb 1 [Epub ahead of print] (2010). *

• Kish DD, Li X, Fairchild RL. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J. Immunol. 182: 5949-5959 (2009).

• Kisielow J, Kopf M, Karjalainen K. SCART scavenger receptors identify a novel subset of adult gammadelta T cells. J. Immunol. 181: 1710-1716 (2008). *

• Kitami S, Tanaka H, Kawato T, Tanabe N, Katono-Tani T, Zhang F, Suzuki N, Yonehara Y, Maeno M. IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells. Biochimie Dec 30 [Epub ahead of print] (2009).

• Kitani A, Xu L. Regulatory T cells and the induction of IL-17. Mucosal Immunol. 1 Suppl. 1: S43-S46 (2008).

• Kivisakk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology 72: 1922-1930 (2009).

• Kleinewietfeld M, Starke M, Mitri DD, Borsellino G, Battistini L, Rotzschke O, Falk K. CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells. Blood 113: 827-836 (2009). *

• Kleinschek MA, Boniface K, Sadekova S, Grein J, Murphy EE, Turner SP, Raskin L, Desai B, Faubion WA, de Waal Malefyt R, Pierce RH, McClanahan T, Kastelein RA. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206: 525-534 (2009). *

• Kleinschek MA, Muller U, Brodie SJ, Stenzel W, Kohler G, Blumenschein WM, Straubinger RK, McClanahan T, Kastelein RA, Alber G. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J. Immunol. 176: 1098-1106 (2006). *

• Kleinschek MA, Muller U, Schutze N, Sabat R, Straubinger RK, Blumenschein WM, McClanahan T, Kastelein RA, Alber G. Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection. Int. Immunol. Nov 30 [Epub ahead of print] (2009).

• Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ. IL-25 regulates Th17 function in autoimmune inflammation. J. Exp. Med. 204: 161-170 (2007). *

• Kleinschnitz C, Hofstetter HH, Meuth SG, Braeuninger S, Sommer C, Stoll G. T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression. Exp. Neurol. 200: 480-485 (2006).

• Klemann C, Je Raveney B, Oki S, Yamamura T. Retinoid signals and Th17-mediated pathology. Nihon Rinsho Meneki Gakkai Kaishi 32: 20-28 (2009). *

• Klemann C, Raveney BJ, Klemann AK, Ozawa T, von Horsten S, Shudo K, Oki S, Yamamura T. Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. Am. J. Pathol. 174: 2234-2245 (2009). *

• Klemens C, Rasp G, Jund F, Hilgert E, Devens C, Pfrogner E, Kramer MF. Mediators and cytokines in allergic and viral-triggered rhinitis. Allergy Asthma Proc. 28: 434-441 (2007).

• Kmiec Z, Sokolowska I. Role of tumor necrosis factor family ligands in the pathogenesis of rheumatoid arthritis - new therapeutical opportunities. Pol. Merkur. Lekarski. 22: 300-304 (2007).

• Knauer J, Siegemund S, Muller U, Al-Robaiy S, Kastelein RA, Alber G, Straubinger RK. Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells. FEMS Immunol. Med. Microbiol. 49: 353-363 (2007). *

• Knebel B, Janssen OE, Hahn S, Jacob S, Gleich J, Kotzka J, Muller-Wieland D. Increased low grade inflammatory serum markers in patients with polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants. Exp. Clin. Endocrinol. Diabetes 116: 481-486 (2008).

• Ko E, Cho KA, Ju SY, Woo SY. Mesenchymal stem cells inhibit the differentiation of CD4+ T cells into interleukin-17-secreting T cells. Acta Haematol. 120: 165-167 (2008).

• Kobayashi E, Kobayashi M, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Halothane-induced liver injury is mediated by interleukin-17 in mice. Toxicol. Sci. 111: 302-310 (2009). *

• Kobayashi N, Kiptoo P, Kobayashi H, Ridwan R, Brocke S, Siahaan TJ. Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. Clin. Immunol. 129: 69-79 (2008). *

• Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe KI, Hibi T. IL-23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 57: 1682-1689 (2008).

• Kochetkova I, Trunkle T, Callis G, Pascual DW. Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells. J. Immunol. 181: 2741-2752 (2008). *

• Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB. Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 58: 3461-3470 (2008). *

• Koenders MI, Joosten LA, van den Berg WB. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann. Rheum. Dis. 65 Suppl. 3: iii29-iii33 (2006). *

• Koenders MI, Kolls JK, Oppers-Walgreen B, Van Den Bersselaar L, Joosten LA, Schurr JR, Schwarzenberger P, Van Den Berg WB, Lubberts E. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum. 52: 3239-3247 (2005). *

• Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Di Padova FE, Boots AM, Gram H, Joosten LA, van den Berg WB. Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am. J. Pathol. 167: 141-149 (2005). *

• Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Kolls JK, Joosten LA, van den Berg WB. Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1. Arthritis Rheum. 52: 975-983 (2005). *

• Koenders MI, Lubberts E, van de Loo FA, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Kolls JK, Di Padova FE, Joosten LA, van den Berg WB. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J. Immunol. 176: 6262-6269 (2006). *

• Koenders MI, van den Berg WB. Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity? Clin. Exp. Immunol. 159: 131-136 (2010). *

• Koenen HJ, Smeets RL, Vink PM, Rijssen EV, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T-cells differentiate into IL-17 producing cells. Blood 112: 2340-2352 (2008). *

• Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y. Possible pathogenic role of Th17 cells for atopic dermatitis. J. Invest. Dermatol. 128: 2625-2630 (2008). *

• Kohno H, Sakai T, Tsuneoka H, Imanishi K, Saito S. Staphylococcal enterotoxin B is involved in aggravation and recurrence of murine experimental autoimmune uveoretinitis via Vbeta8(+)CD4(+) T cells. Exp. Eye Res. 89: 486-493 (2009).

• Kohno M, Tsutsumi A, Matsui H, Sugihara M, Suzuki T, Mamura M, Goto D, Matsumoto I, Ito S, Suguro T, Sumida T. Interleukin-17 gene expression in patients with rheumatoid arthritis. Mod. Rheumatol. 18: 15-22 (2008). *

• Kokkonen H, Soderstrom I, Rocklov J, Hallmans G, Lejon K, Rantapaa Dahlqvist S. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum. 62: 383-391 (2010). *

• Kolls JK. Th17 cells in mucosal immunity and tissue inflammation. Semin. Immunopathol. Feb 25 [Epub ahead of print] (2010).

• Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 21: 467-476 (2004). *

• Kolls JK, McCray PB Jr, Chan YR. Cytokine-mediated regulation of antimicrobial proteins. Nat. Rev. Immunol. 8: 829-835 (2008). *

• Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177: 566-573 (2006). *

• Kondo M, Murakawa Y, Harashima N, Kobayashi S, Yamaguchi S, Harada M. Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies. Immunology 128: e589-e599 (2009).

• Kondo T, Takata H, Matsuki F, Takiguchi M. Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J. Immunol. 182: 1794-1798 (2009).

• Kong JS, Yoo SA, Kim HS, Kim HA, Yea K, Ryu SH, Chung YJ, Cho CS, Kim WU. Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate. Arthritis Rheum. 62: 159-170 (2009). *

• Kong QF, Sun B, Wang GY, Zhai DX, Mu LL, Wang DD, Wang JH, Li R, Li HL. BM stromal cells ameliorate experimental autoimmune myasthenia gravis by altering the balance of Th cells through the secretion of IDO. Eur. J. Immunol. 39: 800-809 (2009). *

• Kopf H, de la Rosa GM, Howard OM, Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int. Immunopharmacol. 7: 1819-1824 (2007).

• Kordasti SY, Afzali B, Lim Z, Ingram W, Hayden J, Barber L, Matthews K, Chelliah R, Guinn B, Lombardi G, Farzaneh F, Mufti GJ. IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome. Br. J. Haematol. 145: 64-72 (2009). *

• Korenaga H, Kono T, Sakai M. Isolation of seven IL-17 family genes from the Japanese pufferfish Takifugu rubripes. Fish Shellfish Immunol. Feb 5 [Epub ahead of print] (2010).

• Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice. J. Clin. Invest. 119: 1626-1637 (2009). *

• Korn T, Anderson AC, Bettelli E, Oukka M. The dynamics of effector T cells and Foxp3(+) regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J. Neuroimmunol. 191: 51-60 (2007).

• Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448: 484-488 (2007). *

• Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu. Rev. Immunol. 27: 485-517 (2009). *

• Korn T, Oukka M, Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 19: 362-371 (2007). *

• Koshy PJ, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann. Rheum. Dis. 61: 704-713 (2002). *

• Kotake S, Kamatani N. The role of IL-17 in joint destruction. Drug News Perspect. 15: 17-23 (2002).

• Kotake S, Nanke Y, Kawamoto M, Yago T, Udagawa N, Ichikawa N, Kobashigawa T, Saito S, Momohara S, Kamatani N, Yamanaka H. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone 45: 627-639 (2009).

• Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103: 1345-1352 (1999). *

• Kotake S, Yago T, Kawamoto M, Nanke Y. The role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis. Nihon Rinsho Meneki Gakkai Kaishi 32: 466-471 (2009).

• Kotloski NJ, Nardelli DT, Peterson SH, Torrealba JR, Warner TF, Callister SM, Schell RF. Interleukin-23 is required for the development of arthritis in Borrelia-vaccinated and -challenged mice. Clin. Vaccine Immunol. 15: 1199-1207 (2008). *

• Kottke T, Sanchez-Perez L, Diaz RM, Thompson J, Chong H, Harrington K, Calderwood SK, Pulido J, Georgopoulos N, Selby P, Melcher A, Vile R. Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res. 67: 11970-11979 (2007). *

• Kovalenko PL, Zhang Z, Cui M, Clinton SK, Fleet JC. 1,25 Dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genomics 11: 26 (2010). *

• Koyama K, Kagamu H, Miura S, Hiura T, Miyabayashi T, Itoh R, Kuriyama H, Tanaka H, Tanaka J, Yoshizawa H, Nakata K, Gejyo F. Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage. Clin. Cancer Res. 14: 6770-6779 (2008). *

• Kramer G, Marberger M. Could inflammation be a key component in the progression of benign prostatic hyperplasia? Curr. Opin. Urol. 16: 25-29 (2006).

• Kramer G, Mitteregger D, Marberger M. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur. Urol. 51: 1202-1216 (2007).

• Kramer JM, Gaffen SL. Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J. Periodontol. 78: 1083-1093 (2007).

• Kramer JM, Hanel W, Shen F, Isik N, Malone JP, Maitra A, Sigurdson W, Swart D, Tocker J, Jin T, Gaffen SL. Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J. Immunol. 179: 6379-6383 (2007). *

• Kreindler JL, Bertrand CA, Lee RJ, Karasic T, Aujla S, Pilewski JM, Frizzell RA, Kolls JK. Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L257-L266 (2009). *

• Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, Heppner FL, Renauld JC, Becher B. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179: 8098-8104 (2007). *

• Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205: 1535-1541 (2008). *

• Kroenke MA, Segal BM. Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis. J. Neurosci. Res. 85: 1685-1693 (2007). *

• Krstic A, Ilic V, Mojsilovic S, Jovcic G, Milenkovic P, Bugarski D. p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells. Growth Factors 27: 79-90 (2009).

• Krstic A, Santibanez JF, Okic I, Mojsilovic S, Kocic J, Jovcic G, Milenkovic P, Bugarski D. Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice. Acta Physiol. (Oxf.) Jan 22 [Epub ahead of print] (2010). *

• Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. Phenotype, distribution, generation, functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114: 1141-1149 (2009). *

• Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, Szeliga W, Wang Y, Liu Y, Welling TH, Elder JT, Zou W. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J. Immunol. 181: 4733-4741 (2008). *

• Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 114: 357-359 (2009). *

• Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W. Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression. J. Immunol. 179: 1423-1426 (2007). *

• Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J, Chang A, Zou W. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J. Immunol. 178: 6730-6733 (2007). *

• Kubo T, Ichimiya S, Tonooka A, Nagashima T, Kikuchi T, Sato N. p63 induces CD4(+) T-cell chemoattractant TARC/CCL17 in human epithelial cells. J. Interferon Cytokine Res. 28: 725-732 (2008).

• Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, et al. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J. Immunol. 179: 5462-5473 (2007). *

• Kuligowska M, Odrowaz-Sypniewska G. Role of interleukin-17 in cartilage and bone destruction in rheumatoid arthritis. Ortop. Traumatol. Rehabil. 6: 235-241 (2004).

• Kullberg MC. Immunology: soothing intestinal sugars. Nature 453: 602-604 (2008). *

• Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, Sher A. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203: 2485-2494 (2006). *

• Kumari J, Larsen AN, Bogwald J, Dalmo RA. Interleukin-17D in Atlantic salmon (Salmo salar): molecular characterization, 3D modelling and promoter analysis. Fish Shellfish Immunol. 27: 647-659 (2009).

• Kunz M, Ibrahim SM. Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009: 979258 (2009). *

• Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y, Takabayashi K, Iwamoto I. Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum. 43: 2455-2463 (2000). *

• Kwan BC, Tam LS, Lai KB, Lai FM, Li EK, Wang G, Chow KM, Li PK, Szeto CC. The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology (Oxford) 48: 1491-1497 (2009).

• Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. Arthritis Rheum. 58: 3820-3830 (2008). *

• Kwong BY, Roberts SJ, Silberzahn T, Filler RB, Neustadter JH, Galan A, Reddy S, Lin WM, Ellis PD, Langford CF, Hayday AC, Girardi M. Molecular analysis of tumor-promoting CD8(+) T cells in two-stage cutaneous chemical carcinogenesis. J. Invest. Dermatol. Nov 19 [Epub ahead of print] (2009). *

• Laan M, Linden. IL-17 as a potential target for modulating airway neutrophilia. Curr. Pharm. Des. 8: 1855-1861 (2002).

• Laan M, Linden A. The IL-17 family of cytokines - applications in respiratory medicine and allergology. Recent Pat. Inflamm. Allergy Drug Discov. 2: 82-91 (2008).

• Lafdil F, Wang H, Park O, Zhang W, Moritoki Y, Yin S, Fu XY, Gershwin ME, Lian ZX, Gao B. Myeloid STAT3 inhibits T-cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology 137: 2125-2135.e2 (2009). *

• Lahmar I, Abou-Bacar A, Abdelrahman T, Guinard M, Babba H, Ben Yahia S, Kairallah M, Speeg-Schatz C, Bourcier T, Sauer A, Villard O, Pfaff AW, Mousli M, Garweg JG, Candolfi E. Cytokine profiles in toxoplasmic and viral uveitis. J. Infect. Dis. 199: 1239-1249 (2009). *

• Lalor MK, Smith SG, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM. Complex cytokine profiles induced by BCG vaccination in UK infants. Vaccine Nov 23 [Epub ahead of print] (2009).

• Lam QL, Ko OK, Zheng BJ, Lu L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc. Natl. Acad. Sci. U.S.A. 105: 14993-14998 (2008). *

• Lamacchia C, Palmer G, Seemayer CA, Talabot-Ayer D, Gabay C. Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist. Arthritis Rheum. 62: 452-462 (2010). *

• Lambiase A, Micera A, Mantelli F, Moretti C, Di Zazzo A, Perrella E, Bonini S, Bonini S. T-helper 17 lymphocytes in ocular cicatricial pemphigoid. Mol. Vis. 15: 1449-1455 (2009). *

• Lamprecht P, Holle J, Gross WL. Update on clinical, pathophysiological and therapeutic aspects in ANCA-associated vasculitides. Curr. Drug Discov. Technol. 6: 241-251 (2009).

• Lan RY, Salunga TL, Tsuneyama K, Lian ZX, Yang GX, Hsu W, Moritoki Y, Ansari AA, Kemper C, Price J, Atkinson JP, Coppel RL, Gershwin ME. Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J. Autoimmun. 32: 43-51 (2009).

• Lan RY, Selmi C, Gershwin ME. The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2). J. Autoimmun. 31: 7-12 (2008).

• Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240 (2005). *

• Lappegard KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE. The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent. J. Biomed. Mater. Res. A. 87: 129-135 (2008).

• Larenas-Linnemann D. Certainties and doubts about sublingual and oral immunotherapy in children. Curr. Opin. Allergy Clin. Immunol. 9: 558-567 (2009).

• Larosa DF, Orange JS. 1. Lymphocytes. J. Allergy Clin. Immunol. 121: S364-S369 (2008). *

• Larranaga CL, Ampuero SL, Luchsinger VF, Carrion FA, Aguilar NV, Morales PR, Palomino MA, Tapia LF, Avendano LF. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr. Infect. Dis. J. Sep 4 [Epub ahead of print] (2009).

• Larsen JM, Bonefeld CM, Poulsen SS, Geisler C, Skov L. IL-23 and T(H)17-mediated inflammation in human allergic contact dermatitis. J. Allergy Clin. Immunol. 123: 486-492 (2009). *

• Latham KA, Whittington KB, Zhou R, Qian Z, Rosloniec EF. Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints. J. Immunol. 174: 3978-3985 (2005). *

• Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'Shea JJ. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381 (2007). *

• Layh-Schmitt G, Colbert RA. The interleukin-23/interleukin-17 axis in spondyloarthritis. Curr. Opin. Rheumatol. 20: 392-397 (2008).

• Le Gouvello S, Bastuji-Garin S, Aloulou N, Mansour H, Chaumette MT, Berrehar F, Seikour A, Charachon A, Karoui M, Leroy K, Farcet JP, Sobhani I. High prevalence of Foxp3 and IL-17 in MMR-proficient colorectal carcinomas. Gut 57: 772-779 (2008). *

• Leavenworth JW, Schellack C, Kim HJ, Lu L, Spee P, Cantor H. Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2. Proc. Natl. Acad. Sci. U.S.A. Jan 21 [Epub ahead of print] (2010). *

• Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem. 276: 1660-1664 (2001). *

• Lee J, Reinke EK, Zozulya AL, Sandor M, Fabry Z. Mycobacterium bovis Bacille Calmette-Guerin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. J. Immunol. 181: 6201-6212 (2008). *

• Lee JH, Cho ML, Kim JI, Moon YM, Oh HJ, Kim GT, Ryu S, Baek SH, Lee SH, Kim HY, Kim SI. Interleukin 17 (IL-17) increases the expression of Toll-like receptor-2, 4, and 9 by increasing IL-1beta and IL-6 production in autoimmune arthritis. J. Rheumatol. 36: 684-692 (2009).

• Lee JW, Bajwa PJ, Carson MJ, Jeske DR, Cong Y, Elson CO, Lytle C, Straus DS. Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice. Gastroenterology 133: 108-123 (2007). *

• Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, Defea K, Straus DS. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J. Immunol. 181: 6536-6545 (2008). *

• Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Cell. Immunol. 251: 50-55 (2008). *

• Lee M, Kovacs-Nolan J, Yang C, Archbold T, Fan MZ, Mine Y. Hen egg lysozyme attenuates inflammation and modulates local gene expression in a porcine model of dextran sodium sulfate (DSS)-induced colitis. J. Agric. Food Chem. 57: 2233-2240 (2009). *

• Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood Nov 12 [Epub ahead of print] (2009). *

• Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental plasticity of Th17 and Treg cells. Curr. Opin. Immunol. 21: 274-280 (2009).

• Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity 30: 92-107 (2009). *

• Lees CW, Zacharias WJ, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Torkvist L, Kao J, Farrington S, Drummond HE, Ho GT, Arnott ID, Appelman HD, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SE, Gumucio DL, Satsangi J. Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med. 5: e239 (2008). *

• Lees JR, Iwakura Y, Russell JH. Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines. J. Immunol. 180: 8066-8072 (2008). *

• LeGrand A, Fermor B, Fink C, Pisetsky DS, Weinberg JB, Vail TP, Guilak F. Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum. 44: 2078-2083 (2001). *

• Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH, Huang B. SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy 63: 327-332 (2008).

• Leibundgut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis E Sousa C. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8: 630-638 (2007). *

• Leipe J, Skapenko A, Schulze-Koops H. Th17 cells - a new proinflammatory T-cell population and its role in rheumatologic autoimmune diseases. Z. Rheumatol. 68: 405-408 (2009).

• Lemmers A, Moreno C, Gustot T, Marechal R, Degre D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V, Le Moine O, Deviere J. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 49: 646-657 (2009). *

• Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA Jr, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A. 106: 5954-5959 (2009). *

• Lenarczyk A, Helsloot J, Farmer K, Peters L, Sturgess A, Kirkham B. Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls. Clin. Exp. Immunol. 122: 41-48 (2000). *

• Leonaviciene L, Bradunaite R, Astrauskas V. Proinflammatory cytokine interleukin-17 and its role in pathogenesis of rheumatoid arthritis. Medicina (Kaunas.) 40: 419-422 (2004).

• Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma expressing Th17 cells drive chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136: 257-267 (2009). *

• Lester SR, Bain JL, Johnson RB, Serio FG. Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss. J. Periodontol. 78: 1545-1550 (2007).

• Leung-Theung-Long S, Guerder S. Th17 cells, a novel proinflammatory effector CD4 T cell population. Med. Sci. (Paris) 24: 972-976 (2008).

• Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, Ayyoub M, Valmori D. Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells. J. Immunother. 32: 101-108 (2009).

• Levin SD. IL-17 receptor signaling: ubiquitin gets in on the act. Sci. Signal. 2: pe64 (2009). *

• Levitz SM. Th17 cells bounce off the fungal wall. Cell Host Microbe 5: 311-313 (2009).

• Lewkowich IP, Lajoie S, Clark JR, Herman NS, Sproles AA, Wills-Karp M. Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice. PLoS ONE 3: e3879 (2008). *

• Lexberg MH, Taubner A, Forster A, Albrecht I, Richter A, Kamradt T, Radbruch A, Chang HD. Th memory for interleukin-17 expression is stable in vivo. Eur. J. Immunol. 38: 2654-2664 (2008). *

• Ley K, Smith E, Stark MA. Neutrophil-regulatory Tn lymphocytes. Immunol. Res. 34: 229-242 (2006). *

• Li B, Reynolds JM, Stout RD, Bernlohr DA, Suttles J. Regulation of Th17 differentiation by epidermal fatty acid-binding protein. J. Immunol. 182: 7625-7633 (2009).

• Li H, Nooh MM, Kotb M, Re F. Commercial peptidoglycan preparations are contaminated with superantigen-like activity that stimulates IL-17 production. J. Leukoc. Biol. 83: 409-418 (2008). *

• Li HB, Han XZ, Feng YZ, Wang JR, Sun Y, Sun LF, Yi YC, Li ZP. Mechanism of conditioned immune response in curing bronchial asthma in mice. Zhonghua Er Ke Za Zhi 46: 924-929 (2008).

• Li J, Chen X, Liu Z, Yue Q, Liu H. Expression of Th17 cytokines in skin lesions of patients with psoriasis. J. Huazhong Univ. Sci. Technolog. Med. Sci. 27: 330-332 (2007).

• Li J, Li D, Tan Z. The expression of interleukin-17, interferon-gamma, and macrophage inflammatory protein-3 alpha mRNA in patients with psoriasis vulgaris. J. Huazhong Univ. Sci. Technolog. Med. Sci. 24: 294-296 (2004).

• Li J, Li L, Shang X, Benson J, Merle Elloso M, Schantz A, Bracht M, Orlovsky Y, Sweet R. Negative regulation of IL-17 production by OX40/OX40L interaction. Cell. Immunol. 253: 31-37 (2008). *

• Li J, Zhu X, Liu F, Cai P, Sanders C, Lee WM, Uetrecht J. Cytokine and autoantibody patterns in acute liver failure. J. Immunotoxicol. Dec 29 [Epub ahead of print] (2009).

• Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J. Clin. Invest. pii: 38702 (2009). *

• Li Q, Nacion K, Bu H, Lin F. The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis. Am. J. Pathol. 175: 661-667 (2009). *

• Li TS, Li XN, Chang ZJ, Fu XY, Liu L. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway. Cell. Signal. 18: 1287-1298 (2006). *

• Li X. Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling. Cytokine 41: 105-113 (2008).

• Li X, Afif H, Cheng S, Martel-Pelletier J, Pelletier JP, Ranger P, Fahmi H. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. J. Rheumatol. 32: 887-895 (2005).

• Li Z, Liu B, Maminishkis A, Mahesh SP, Yeh S, Lew J, Lim WK, Sen HN, Clarke G, Buggage R, Miller SS, Nussenblatt RB. Gene expression profiling in autoimmune noninfectious uveitis disease. J. Immunol. 181: 5147-5157 (2008). *

• Liang J, Zheng Z, Wang M, Han L, Zheng Z, Peng J, Liu Z, Wei Y. Myeloperoxidase (MPO) and interleukin-17 (IL-17) plasma levels are increased in patients with acute coronary syndromes. J. Int. Med. Res. 37: 862-866 (2009).

• Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, Goldman SJ, Dunussi-Joannopoulos K, Williams CM, Wright JF, Fouser LA. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J. Immunol. 179: 7791-7799 (2007). *

• Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203: 2271-2279 (2006). *

• Liao JJ, Huang MC, Goetzl EJ. Cutting edge: alternative signaling of Th17 cell development by sphingosine 1-phosphate. J. Immunol. 178: 5425-5428 (2007). *

• Lim HW, Lee J, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J. Immunol. 180: 122-129 (2008). *

• Lin L, Ibrahim AS, Xu X, Farber JM, Avanesian V, Baquir B, Fu Y, French SW, Edwards JE, Spellberg B. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog. 5: e1000703 (2009). *

• Lin S, Huang YL, Wu WF, Li Y, Tang SD. Role of interleukin 17 in viral myocarditis and dilated cardiomyopathy. Nan Fang Yi Ke Da Xue Xue Bao 29: 1994-199 (2009).

• Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31: 799-810 (2009). *

• Lin Y, Slight SR, Khader SA. Th17 cytokines and vaccine-induced immunity. Semin. Immunopathol. Jan 30 [Epub ahead of print] (2010). *

• Lindemann MJ, Hu Z, Benczik M, Liu KD, Gaffen SL. Differential regulation of the IL-17 receptor by gamma c cytokines: inhibitory signaling by the phosphatidylinositol 3'-kinase pathway. J. Biol. Chem. 283: 14100-14108 (2008). *

• Linden A. Role of interleukin-17 and the neutrophil in asthma. Int. Arch. Allergy Immunol. 126: 179-184 (2001).

• Linden A. A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling. Sci. STKE 398: re4 (2007). *

• Linden A. Rationale for targeting interleukin-17 in the lungs. Curr. Opin. Investig. Drugs 4: 1304-1312 (2003).

• Linden A. Interleukin-17 and airway remodelling. Pulm. Pharmacol. Ther. 19: 47-50 (2006).

• Linden A, Hoshino H, Laan M. Airway neutrophils and interleukin-17. Eur. Respir. J. 15: 973-977 (2000). *

• Linden A, Laan M, Anderson GP. Neutrophils, interleukin-17A and lung disease. Eur. Respir. J. 25: 159-172 (2005). *

• Liseth K, Sjo M, Paulsen K, Bruserud O, Ersvaer E. Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease. Eur. Cytokine Netw. 21: 40-49 (2010).

• Litjens NH, van de Wetering J, van Besouw NM, Betjes MG. The human alloreactive CD4+ T cell repertoire is biased to a Th-17 response and the frequency is inversely related with the number of HLA class II mismatches. Blood 114: 3947-3955 (2009). *

• Liu C, Qian W, Qian Y, Giltiay NV, Lu Y, Swaidani S, Misra S, Deng L, Chen ZJ, Li X. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci. Signal. 2: ra63 (2009). *

• Liu F, Yin HB, Su C. Th17 in the immunity against parasitic infection. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 26: 382-386 (2008).

• Liu GQ, Wu HY, Zhang GB, Ma HB, Ma ZN, Ju SG, Zhang XG. Prokaryotic expression, purification and biological activity of recombinant human IL-17/His protein. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 715-718 (2007).

• Liu H, Rohowsky-Kochan C. Regulation of IL-17 in human CCR6+ effector memory T cells. J. Immunol. 180: 7948-7957 (2008). *

• Liu J, Lin F, Strainic MG, An F, Miller RH, Altuntas CZ, Heeger PS, Tuohy VK, Medof ME. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J. Immunol. 180: 5882-5889 (2008). *

• Liu JQ, Carl JW Jr, Joshi PS, Raychaudhury A, Pu XA, Shi FD, Bai XF. CD24 on the resident cells of the central nervous system enhances experimental autoimmune encephalomyelitis. J. Immunol. 178: 6227-6235 (2007). *

• Liu JZ, Pezeshki M, Raffatellu M. Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm. Cytokine 48: 156-160 (2009).

• Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit. Care 13: R104 (2009).

• Liu L, Xu Y, Wang J, Li H. Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU). Mol. Vis. 15: 2938-2944 (2009). *

• Liu L, Yang P, He H, Lin X, Jiang L, Chi W, Zhao C, Zhou H. Leptin increases in Vogt-Koyanagi-Harada (VKH) disease and promotes cell proliferation and inflammatory cytokine secretion. Br. J. Ophthalmol. 92: 557-561 (2008).

• Liu M, Hu X, Wang Y, Peng F, Yang Y, Chen X, Lu Z, Zheng X. Effect of high-dose methylprednisolone treatment on Th17 cells in patients with multiple sclerosis in relapse. Acta Neurol. Scand. 120: 235-241 (2009). *

• Liu N, Nguyen L, Chun RF, Lagishetty V, Ren S, Wu S, Hollis B, Deluca HF, Adams JS, Hewison M. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology 149: 4799-4808 (2008). *

• Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH. p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am. J. Pathol. 174: 153-163 (2009). *

• Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J. Leukoc. Biol. 82: 354-360 (2007). *

• Liu W, Feng W, Wang F, Li W, Gao C, Zhou B, Ma M. Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease. Exp. Mol. Pathol. 84: 213-217 (2008).

• Liu W, Feng W, Wang F, Li W, Zhou B, Gao C, Li Y, Kong Y, Ma M, Fu S. Adenovirus-mediated ICOSIg gene transfer alleviates cardiac remodeling in experimental autoimmune myocarditis. Immunol. Cell. Biol. 86: 659-665 (2008). *

• Liu X, Lee YS, Yu CR, Egwuagu CE. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol. 180: 6070-6076 (2008). *

• Liu X, Yang P, Lin X, Ren X, Zhou H, Huang X, Chi W, Kijlstra A, Chen L. Inhibitory effect of cyclosporin A and corticosteroids on the production of IFN-gamma and IL-17 by T cells in Vogt-Koyanagi-Harada syndrome. Clin. Immunol. 131: 333-342 (2009). *

• Liu XF, Shi Y, Zhang JY, Zhuang Y, Jia KR, Mao XH, Guo Y, Liu T, Liu Z, Wu C, Zhang WJ, Zhou WY, Guo G, Zou QM. Efficient adenovirus-mediated gene transfer to gastric tissue by oral administration. J. Gene Med. 11: 1087-1094 (2009).

• Liu XK, Clements JL, Gaffen SL. Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells. Mol. Cells 20: 339-347 (2005). *

• Liu Y, Yang B, Zhou M, Li L, Zhou H, Zhang J, Chen H, Wu C. Memory IL-22-producing CD4(+) T cells specific for Candida albicans are present in humans. Eur. J. Immunol. 39: 1472-1479 (2009). *

• Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J. Immunol. 182: 572-580 (2009). *

• Liu Z, Jiu J, Liu S, Fa X, Li F, Du Y. Blockage of tumor necrosis factor prevents intestinal mucosal inflammation through down-regulation of interleukin-23 secretion. J. Autoimmun. 29: 187-194 (2007).

• Liu Z, Noh HS, Chen J, Kim JH, Falo LD Jr, You Z. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J. Immunol. 181: 4363-4370 (2008). *

• Liu Z, Yang L, Cui Y, Wang X, Guo C, Huang Z, Kan Q, Liu Z, Liu Y. IL-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Inflamm. Bowel Dis. 15: 1133-1144 (2009). *

• Liu Z, Yuan X, Luo Y, He Y, Jiang Y, Chen ZK, Sun E. Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine 45: 141-147 (2009).

• Llopis M, Antolin M, Carol M, Borruel N, Casellas F, Martinez C, Espin-Basany E, Guarner F, Malagelada JR. Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa. Inflamm. Bowel Dis. 15: 275-283 (2009). *

• Lo CK, Lam QL, Sun L, Wang S, Ko KH, Xu H, Wu CY, Zheng BJ, Lu L. Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum. 58: 2700-2711 (2008). *

• Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, Riethmacher D, Si-Tahar M, Di Santo JP, Eberl G. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J. Exp. Med. 205: 1381-1393 (2008). *

• Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J. Immunol. 177: 4662-4669 (2006). *

• Loddenkemper C, Nagorsen D, Zeitz M. Foxp3 and microsatellite stability phenotype in colorectal cancer. Gut 57: 725-726 (2008).

• Loffredo S, Ayala F, Marone G, Delfino G, Stranges S, Marone G. Immunopathogenesis of psoriasis and pharmacological perspectives. J. Rheumatol. Suppl. 83: 9-11 (2009).

• Lohr J, Knoechel B, Caretto D, Abbas AK. Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect. 11: 589-593 (2009). *

• Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 203: 2785-2791 (2006). *

• Lombardi V, Van Overtvelt L, Horiot S, Moingeon P. Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells. J. Immunol. 182: 3372-3379 (2009).

• Loos M, Remaut E, Rottiers P, De Creus A. Genetically engineered Lactococcus lactis secreting murine IL-10 modulates the functions of bone marrow-derived dendritic cells in the presence of LPS. Scand. J. Immunol. 69: 130-139 (2009). *

• Lopez P, Gueimonde M, Margolles A, Suarez A. Distinct Bifidobacterium strains drive different immune responses in vitro. Int. J. Food Microbiol. Jan 4 [Epub ahead of print] (2010). *

• Loures FV, Pina A, Felonato M, Calich VL. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J. Immunol. 183: 1279-1290 (2009).

• Louten J, Boniface K, de Waal Malefyt R. Development and function of TH17 cells in health and disease. J. Allergy Clin. Immunol. 123: 1004-1011 (2009). *

• Lowder T, Dugger K, Deshane J, Estell K, Schwiebert LM. Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model. Brain Behav. Immun. 24: 153-159 (2010).

• Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, Bowman EP, Krueger JG. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J. Invest. Dermatol. 128: 1207-1211 (2008). *

• Lu TT, Zhu P, Li XY, Fan CM. Functional status of T helper cells in rheumatoid arthritis and effect of etanercept. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 495-497 (2008).

• Lu X, Zhu C, Qian J, Chen X, Ye S, Gu Y. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection. Lupus Feb 23 [Epub ahead of print] (2010).

• Lu YJ, Forte S, Thompson CM, Anderson PW, Malley R. Protection against pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide. Infect. Immun. 77: 2076-2083 (2009). *

• Lubberts E. IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 41: 84-91 (2008).

• Lubberts E. The role of IL-17 and family members in the pathogenesis of arthritis. Curr. Opin. Investig. Drugs 4: 572-577 (2003).

• Lubberts E. Th17 cytokines and arthritis. Semin. Immunopathol. Feb 4 [Epub ahead of print] (2010). *

• Lubberts E, Joosten LA, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J. Clin. Invest. 105: 1697-1710 (2000). *

• Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J. Immunol. 167: 1004-1013 (2001). *

• Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 50: 650-659 (2004). *

• Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res. Ther. 7: 29-37 (2005). *

• Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, Kolls JK. Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis. J. Immunol. 175: 3360-3368 (2005). *

• Lubberts E, van den Berg WB. Potential of modulatory cytokines in the rheumatoid arthritis process. Drug News Perspect. 14: 517-522 (2001).

• Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, van den Berg WB. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J. Immunol. 170: 2655-2662 (2003). *

• Lucia A, Smith L, Naidoo M, Gonzalez-Freire M, Perez M, Rubio JC, Martin MA, Andreu AL, Arenas J. McArdle disease: another systemic low-inflammation disorder? Neurosci. Lett. 431: 106-111 (2008). *

• Luger D, Caspi RR. New perspectives on effector mechanisms in uveitis. Semin. Immunopathol. 30: 135-143 (2008). *

• Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205: 799-810 (2008). *

• Lundy SK, Fox DA. Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis. Arthritis Res. Ther. 11: R128 (2009). *

• Lundy SK, Sarkar S, Tesmer LA, Fox DA. Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res. Ther. 9: 202 (2007). *

• Luo Y, Huang WM. Study of 17 immune cytokines in the peripheral blood of premature infants with chronic lung disease. Nan Fang Yi Ke Da Xue Xue Bao 30: 331-333 (2010).

• Luzza F, Parrello T, Monteleone G, Sebkova L, Romano M, Zarrilli R, Imeneo M, Pallone F. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J. Immunol. 165: 5332-5337 (2000). *

• Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F. Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol. Rev. 226: 112-131 (2008). *

• Lytle C, Tod TJ, Vo KT, Lee JW, Atkinson RD, Straus DS. The peroxisome proliferator-activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency. Inflamm. Bowel Dis. 11: 231-243 (2005). *

• Ma CS, Chew GY, Simpson N, Priyadarshi A, Wong M, Grimbacher B, Fulcher DA, Tangye SG, Cook MC. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J. Exp. Med. 205: 1551-1557 (2008). *

• Ma D, Zhu X, Zhao P, Zhao C, Li X, Zhu Y, Li L, Sun J, Peng J, Ji C, Hou M. Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann. Hematol. 87: 899-904 (2008). *

• Ma HL, Napierata L, Stedman N, Benoit S, Collins M, Nickerson-Nutter C, Young DA. Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. Arthritis Rheum. 62: 430-440 (2010). *

• Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S. Morphine disrupts the IL-23/IL-17 mediated pulmonary mucosal host defense against S. pneumoniae infection. Infect. Immun. Dec 7 [Epub ahead of print] (2009). *

• Ma R, Yang BY, Wu CY. A selective phosphodiesterase 4 (PDE4) inhibitor Zl-n-91 suppresses IL-17 production by human memory Th17 cells. Int. Immunopharmacol. 8: 1408-1417 (2008).

• Ma Y, Guan Q, Bai A, Weiss CR, Hillman CL, Ma A, Zhou G, Qing G, Peng Z. Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflamm. Bowel Dis. Nov 18 [Epub ahead of print] (2009). *

• Ma Y, Visser L, Blokzijl T, Harms G, Atayar C, Poppema S, van den Berg A. The CD4+CD26- T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile. Lab. Invest. 88: 482-490 (2008). *

• Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, Brender T, Okada S, Lum K, West J, Kuijper JL, Ardourel D, Franke S, Lockwood L, Vu T, Frank A, Appleby MW, Wolf A, Reardon B, Hamacher NB, Stevens B, Lewis P, Lewis KB, et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng. Des. Sel. Dec 18 [Epub ahead of print] (2009).

• Maccoux LJ, Salway F, Day PJ, Clements DN. Expression profiling of select cytokines in canine osteoarthritis tissues. Vet. Immunol. Immunopathol. 118: 59-67 (2007). *

• Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ, Harrison DG. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension Dec 28 [Epub ahead of print] (2009).

• Madia F, Frisullo G, Nociti V, Conte A, Luigetti M, Del Grande A, Patanella AK, Iorio R, Tonali PA, Batocchi AP, Sabatelli M. pSTAT1, pSTAT3, and T-bet as markers of disease activity in chronic inflammatory demyelinating polyradiculoneuropathy. J. Peripher. Nerv. Syst. 14: 107-117 (2009).

• Maek-A-Nantawat W, Buranapraditkun S, Klaewsongkram J, Ruxrungthum K. Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection. Viral Immunol. 20: 66-75 (2007).

• Mahanonda R, Jitprasertwong P, Sa-Ard-Iam N, Rerkyen P, Charatkulangkun O, Jansisyanont P, Nisapakultorn K, Yongvanichit K, Pichyangkul S. Effects of IL-17 on human gingival fibroblasts. J. Dent. Res. 87: 267-272 (2008).

• Mahendra A, Misra R, Aggarwal A. Th1 and Th17 predominance in the enthesitis-related srthritis form of juvenile idiopathic arthritis. J. Rheumatol. 36: 1730-1736 (2009).

• Maione F, Pashalidis N, Mascolo N, Dufton N, Perretti M, D'Acquisto F. Interleukin 17 sustains rather than induces inflammation. Biochem. Pharmacol. 77: 878-887 (2009). *

• Maitra A, Shen F, Hanel W, Mossman K, Tocker J, Swart D, Gaffen SL. Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc. Natl. Acad. Sci. U.S.A. 104: 7506-7511 (2007). *

• Maitra U, Davis S, Reilly CM, Li L. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J. Immunol. 182: 5763-5769 (2009).

• Malamut G. IL-17/IL-23: a new therapeutic target in the inflammatory bowel diseases. Gastroenterol. Clin. Biol. 32: 354-356 (2008).

• Malemud CJ. Cytokines as therapeutic targets for osteoarthritis. BioDrugs 18: 23-35 (2004).

• Malemud CJ. Anticytokine therapy for osteoarthritis: evidence to date. Drugs Aging 27: 95-115 (2010).

• Maloy KJ. The interleukin-23/interleukin-17 axis in intestinal inflammation. J. Intern. Med. 263: 584-590 (2008). *

• Malur A, McCoy AJ, Arce S, Barna BP, Kavuru MS, Malur AG, Thomassen MJ. Deletion of PPARgamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J. Immunol. 182: 5816-5822 (2009).

• Mandel M, Achiron A, Tuller T, Barliya T, Rechavi G, Amariglio N, Loewenthal R, Lavie G. Clone clusters in autoreactive CD4 T-cell lines from probable multiple sclerosis patients form disease-characteristic signatures. Immunology 128: 287-300 (2009). *

• Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9: 641-649 (2008). *

• Mangalam A, Luckey D, Basal E, Jackson M, Smart M, Rodriguez M, David C. HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J. Immunol. 182: 5131-5139 (2009).

• Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441: 231-234 (2006). *

• Mannon PJ, Fuss IJ, Dill S, Friend J, Groden C, Hornung R, Yang Z, Yi C, Quezado M, Brown M, Strober W. Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology 131: 748-756 (2006). *

• Manukyan GP, Ghazaryan KA, Ktsoyan ZA, Tatyan MV, Khachatryan ZA, Hakobyan GS, Mkrtchyan VA, Kelly D, Coutts A, Aminov RI. Cytokine profile of Armenian patients with familial Mediterranean fever. Clin. Biochem. 41: 920-922 (2008). *

• Mao F, Xu WR, Qian H, Zhu W, Yan YM, Shao QX, Xu HX. Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis. Inflamm. Res. Sep 10 [Epub ahead of print] (2009). *

• Marengo EB, Commodaro AG, Peron JP, de Moraes LV, Portaro FC, Belfort R, Rizzo LV, Sant'anna OA. Administration of Mycobacterium leprae rHsp65 aggravates experimental autoimmune uveitis in mice. PLoS One 4: e7912 (2009). *

• Marino E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST. CD4+ CD25+ T cells control autoimmunity in the absence of B cells. Diabetes 58: 1568-1577 (2009). *

• Markovic M, Miljkovic D, Momcilovic M, Popadic D, Miljkovic Z, Savic E, Ramic Z, Mostarica Stojkovic M. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Mol. Immunol. 47: 141-146 (2009). *

• Marks BR, Craft J. Barrier immunity and IL-17. Semin. Immunol. 21: 164-171 (2009). *

• Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat. Immunol. 11: 97 (2010).

• Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat. Immunol. 10: 1125-1132 (2009). *

• Marks MA, Gravitt PE, Burk RR, Studentsov Y, Farzadegan H, Klein SL. Progesterone and 17beta-estradiol enhance regulatory responses to HPV 16 VLP in peripheral blood mononuclear cells from healthy women. Clin. Vaccine Immunol. Feb 3 [Epub ahead of print] (2010). *

• Mars LT, Araujo L, Kerschen P, Diem S, Bourgeois E, Van LP, Carrie N, Dy M, Liblau RS, Herbelin A. Invariant NKT cells inhibit development of the Th17 lineage. Proc. Natl. Acad. Sci. U.S.A. 106: 6238-6243 (2009). *

• Marsland BJ, Nembrini C, Grun K, Reissmann R, Kurrer M, Leipner C, Kopf M. TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-{theta} signaling and promote autoimmune myocarditis. J. Immunol. 178: 3466-3473 (2007). *

• Marta M, Andersson A, Isaksson M, Kampe O, Lobell A. Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur. J. Immunol. 38: 565-575 (2008). *

• Martel-Pelletier J, Mineau F, Jovanovic D, Di Battista JA, Pelletier JP. Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated … Arthritis Rheum. 42: 2399-2409 (1999). *

• Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-330 (2009). *

• Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 39: 216-224 (2009). *

• Martin-Orozco N, Dong C. The IL-17/IL-23 axis of inflammation in cancer: friend or foe? Curr. Opin. Investig. Drugs 10: 543-549 (2009).

• Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31: 787-798 (2009). *

• Martin-Saavedra FM, Flores N, Dorado B, Eguiluz C, Bravo B, Garcia-Merino A, Ballester S. Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis. Mol. Immunol. 44: 3597-3607 (2007). *

• Martin-Saavedra FM, Gonzalez-Garcia C, Bravo B, Ballester S. Beta interferon restricts the inflammatory potential of CD4(+) cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells. Mol. Immunol. 45: 4008-4019 (2008). *

• Martins de Sousa E, Bonfim de Bortoli F, Amaral EP, Batista AC, Kipnis TL, Cardoso AM, Kipnis A, Junqueira-Kipnis AP. Acute immune response to Mycobacterium massiliense in C57BL/6 and BALB/c mice. Infect. Immun. Feb 1 [Epub ahead of print] (2010). *

• Marusic S, Thakker P, Pelker JW, Stedman NL, Lee KL, McKew JC, Han L, Xu X, Wolf SF, Borey AJ, Cui J, Shen MW, Donahue F, Hassan-Zahraee M, Leach MW, Shimizu T, Clark JD. Blockade of cytosolic phospholipase A(2)alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses. J. Neuroimmunol. 204: 29-37 (2008).

• Marx J. Biomedicine. Puzzling out the pains in the gut. Science 315: 33-35 (2007). *

• Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10 deficient mice. Gastroenterology 137: 1380-1390.e1-e3 (2009). *

• Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH. T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood 108: 1595-1601 (2006). *

• Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J. Immunol. 178: 4901-4907 (2007). *

• Matos-Souza JR, Pithon KR, Ozahata TM, Oliveira RT, Téo FH, Blotta MH, Cliquet A Jr, Nadruz W Jr. Subclinical atherosclerosis is related to injury level but not to inflammatory parameters in spinal cord injury subjects. Spinal Cord. Feb 16 [Epub ahead of print] (2010).

• Matsui M. Roles of the novel interleukin-12-associated cytokine, interleukin-23, in the regulation of T-cell-mediated immunity. Hepatol. Res. 37 Suppl. 3: S310-S318 (2007).

• Matsuki T, Nakae S, Sudo K, Horai R, Iwakura Y. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int. Immunol. 18: 399-407 (2006). *

• Matsumoto K, Kanmatsuse K. Interleukin-17 stimulates the release of pro-inflammatory cytokines by blood monocytes in patients with IgA nephropathy. Scand. J. Urol. Nephrol. 37: 164-171 (2003).

• Matsumura M, Nagata M, Nakamura K, Kawai M, Baba T, Yamaki K, Yoshino S. Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice. Immunopharmacol. Immunotoxicol. Oct 8 [Epub ahead of print] (2009).

• Matsunaga K. The utility of exhaled breath condensate analysis for asthma management. Rinsho Byori 55: 375-380 (2007).

• Matsunaga K, Ichikawa T, Yanagisawa S, Akamatsu K, Koarai A, Hirano T, Sugiura H, Minakata Y, Ichinose M. Clinical application of exhaled breath condensate analysis in asthma: prediction of FEV(1) improvement by steroid therapy. Respiration 78: 393-398 (2009).

• Matsuzaki G, Umemura M. Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol. Immunol. 51: 1139-1147 (2007). *

• Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5: 101-104 (1999). *

• Maue AC, Eaton SM, Lanthier PA, Sweet KB, Blumerman SL, Haynes L. Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J. Immunol. 182: 6129-6135 (2009).

• Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L. Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated GvH disease. Am. J. Respir. Crit. Care Med. 178: 379-388 (2008). *

• Maxmen A. IL-17 propels infection. J. Exp. Med. 206: 1210 (2009).

• Maxmen A. Flagging Th17 in Crohn's. J. Exp. Med. 206: 492-493 (2009). *

• Maxmen A. Antibodies attack IL-17. J. Exp. Med. Feb 1 [Epub ahead of print] (2010). *

• Maxmen A. Revising the Th17 recipe. J. Exp. Med. 206: 2304 (2009).

• Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453: 620-625 (2008). *

• Mc Quillan KL, Lynch MA, Mills KH. Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells. Brain Behav. Immun. Jan 7 [Epub ahead of print] (2010).

• McAllister F, Henry A, Kreindler JL, Dubin PJ, Ulrich L, Steele C, Finder JD, Pilewski JM, Carreno BM, Goldman SJ, Pirhonen J, Kolls JK. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J. Immunol. 175: 404-412 (2005). *

• McBee ME, Zheng PZ, Rogers AB, Fox JG, Schauer DB. Modulation of acute diarrheal illness by persistent bacterial infection. Infect. Immun. 76: 4851-4858 (2008). *

• McCandless EE, Budde M, Lees JR, Dorsey D, Lyng E, Klein RS. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. J. Immunol. 183: 613-620 (2009).

• McClain MA, Gatson NN, Powell ND, Papenfuss TL, Gienapp IE, Song F, Shawler TM, Kithcart A, Whitacre CC. Pregnancy suppresses experimental autoimmune encephalomyelitis through immunoregulatory cytokine production. J. Immunol. 179: 8146-8152 (2007). *

• McGeachy MJ, Anderton SM. Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis. Cytokine 32: 81-84 (2005).

• McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8: 1390-1397 (2007). *

• McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 10: 314-324 (2009). *

• McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin. Immunol. 19: 372-376 (2007). *

• McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity 28: 445-453 (2008). *

• McGee HS, Stallworth AL, Agrawal T, Shao Z, Lorence L, Agrawal DK. Flt3-ligand decreases Th17 cells and SOCS proteins in the lung of house dust mite-sensitized and challenged mice. Am. J. Respir. Cell. Mol. Biol. Nov 20 [Epub ahead of print] (2009). *

• McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD. Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. Inflamm. Bowel Dis. 15: 883-889 (2009). *

• Mchenga SS, Wang D, Li C, Shan F, Lu C. Inhibitory effect of recombinant IL-25 on the development of dextran sulfate sodium-induced experimental colitis in mice. Cell. Mol. Immunol. 5: 425-431 (2008). *

• McInnes IB, Liew FY. Cytokine networks - towards new therapies for rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 1: 31-39 (2005). *

• McKenzie BS, Kastelein RA, Cua DJ. Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 27: 17-23 (2006). *

• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 181: 4089-4097 (2008). *

• McNeal MM, Basu M, Bean JA, Clements JD, Choi AH, Ward RL. Identification of an immunodominant CD4(+) T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/c mice. Virology 363: 410-418 (2007). *

• Meeks KD, Sieve AN, Kolls JK, Ghilardi N, Berg RE. IL-23 is required for protection against systemic infection with Listeria monocytogenes. J. Immunol. 183: 8026-8034 (2009). *

• Meemboor S, Mertens J, Flenner E, Groneck L, Zingarelli A, Gamstatter T, Bessler M, Seeger JM, Kashkar H, Odenthal M, Kalka-Moll WM. Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation. Innate Immun. Nov 6 [Epub ahead of print] (2009).

• Mejias A, Chavez-Bueno S, Raynor MB, Connolly J, Kiener PA, Jafri HS, Ramilo O. Motavizumab, a neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibody significantly modifies the local and systemic cytokine responses induced by RSV in the mouse model. Virol. J. 4: 109 (2007). *

• Melgar S, Karlsson A, Michaelsson E. Acute colitis induced by dextran sulphate sodium progresses into chronicity in C57BL/6 but not in BALB/c mice - correlation between symptoms and inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G1328-G1338 (2005). *

• Melgert BN, Timens W, Kerstjens HA, Geerlings M, Luinge MA, Schouten JP, Postma DS, Hylkema MN. Effects of 4 months of smoking in mice with ovalbumin-induced airway inflammation. Clin. Exp. Allergy 37: 1798-1808 (2007). *

• Melis L, Vandooren B, Kruithof E, Jacques P, De Vos M, Mielants H, Verbruggen G, De Keyser F, Elewaut D. Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. Ann. Rheum. Dis. Feb 5 [Epub ahead of print] (2009).

• Melzer N, Meuth SG, Torres-Salazar D, Bittner S, Zozulya AL, Weidenfeller C, Kotsiari A, Stangel M, Fahlke C, Wiendl H. A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis. PLoS ONE 3: e3149 (2008). *

• Mensah-Brown EP, Al Rabesi Z, Shahin A, Al Shamsi M, Arsenijevic N, Hsu DK, Liu FT, Lukic ML. Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice. Clin. Immunol. 130: 83-88 (2009). *

• Mensah-Brown EP, Shahin A, Al-Shamisi M, Wei X, Lukic ML. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. Eur. J. Immunol. 36: 216-223 (2006). *

• Mesa MC, Gutierrez L, Duarte-Rey C, Angel J, Franco MA. A TGF-beta mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children. Virology Jan 21 [Epub ahead of print] (2010). *

• Mesquita D Jr, Cruvinel WM, Camara NO, Kallas EG, Andrade LE. Autoimmune diseases in the TH17 era. Braz. J. Med. Biol. Res. 42: 476-486 (2009). *

• Metz M, Maurer M. Innate immunity and allergy in the skin. Curr. Opin. Immunol. 21: 687-693 (2009).

• Metzger K, Fremont M, Roelant C, De Meirleir K. Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients. Biochem. Biophys. Res. Commun. 376: 231-233 (2008). *

• Meyer T, Stockfleth E, Christophers E. Immune response profiles in human skin. Br. J. Dermatol. 157 Suppl. 2: 1-7 (2007).

• Meyers JA, Mangini AJ, Nagai T, Roff CF, Sehy D, van Seventer GA, van Seventer JM. Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC. Cytokine 35: 235-246 (2006).

• Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, Wong CH, Schneider E, Dy M, Leite-de-Moraes MC. Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J. Exp. Med. 204: 995-1001 (2007). *

• Michel ML, Mendes-da-Cruz D, Keller AC, Lochner M, Schneider E, Dy M, Eberl G, Leite-de-Moraes MC. Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 105: 19845-19850 (2008). *

• Michelow IC, Katz K, McCracken GH, Hardy RD. Systemic cytokine profile in children with community-acquired pneumonia. Pediatr. Pulmonol. 42: 640-645 (2007).

• Migita K, Koga T, Torigoshi T, Maeda Y, Miyashita T, Izumi Y, Aiba Y, Komori A, Nakamura M, Motokawa S, Ishibashi H. Serum amyloid A protein stimulates CCL20 production in rheumatoid synoviocytes. Rheumatology (Oxford) 48: 741-747 (2009).

• Miljkovic D, Dekanski D, Miljkovic Z, Momcilovic M, Mostarica-Stojkovic M. Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis. Clin. Nutr. 28: 346-350 (2009).

• Miljkovic D, Momcilovic M, Stojanovic I, Stosic-Grujicic S, Ramic Z, Mostarica-Stojkovic M. Astrocytes stimulate interleukin-17 and interferon-gamma production in vitro. J. Neurosci. Res. 85: 3598-3606 (2007).

• Miljkovic D, Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev. 15: 21-32 (2004).

• Miljkovic Z, Momcilovic M, Miljkovic D, Mostarica-Stojkovic M. Methylprednisolone inhibits IFN-gamma and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis. J. Neuroinflammation 6: 37 (2009).

• Mills KH. Induction, function and regulation of IL-17-producing T cells. Eur. J. Immunol. 38: 2636-2649 (2008). *

• Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452: 773-776 (2008). *

• Min SI, Ha J, Park CG, Won JK, Park YJ, Min SK, Kim SJ. Sequential evolution of IL-17 responses in the early period of allograft rejection. Exp. Mol. Med. 41: 707-716 (2009). *

• Miossec P. Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum. 48: 594-601 (2003). *

• Miossec P. Diseases that may benefit from manipulating the Th17 pathway. Eur. J. Immunol. 39: 667-669 (2009). *

• Miossec P. IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect. 11: 625-630 (2009). *

• Miossec P. An update on the cytokine network in rheumatoid arthritis. Curr. Opin. Rheumatol. 16: 218-222 (2004).

• Miossec P. IL-17 in rheumatoid arthritis: a new target for treatment or just another cytokine? Joint Bone Spine 71: 87-90 (2004).

• Miossec P. Cytokines in rheumatoid arthritis: is it all TNF-alpha? Cell. Mol. Biol. (Noisy-le-grand) 47: 675-678 (2001).

• Miossec P. Interleukin-17 in fashion, at last: ten years after its description, its cellular source has been identified. Arthritis Rheum. 56: 2111-2115 (2007). *

• Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr. Opin. Rheumatol. 12: 181-185 (2000).

• Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361: 888-898 (2009). *

• Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J. Immunol. 173: 1463-1476 (2004). *

• Miranda-Carus ME, Benito-Miguel M, Balsa A, Cobo-Ibanez T, Perez de Ayala C, Pascual-Salcedo D, Martin-Mola E. Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum. 54: 1151-1164 (2006). *

• Mirkov I, Stojanovic I, Stosic-Grujicic S, Glamoclija J, Zolotarevski L, Kataranovski D, Kataranovski M. Splenic and lung response to nonlethal systemic Aspergillus fumigatus infection in C57BL/6 mice. Med. Mycol. Jan 26 [Epub ahead of print] (2010). *

• Mirshafiey A, Mohsenzadegan M. TGF-beta as promising option in treatment of multiple sclerosis. Neuropharmacology 56: 929-936 (2009).

• Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS. A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J. Immunol. 179: 6596-6603 (2007). *

• Mitchell P, Afzali B, Lombardi G, Lechler RI. The T helper 17-regulatory T cell axis in transplant rejection and tolerance. Curr. Opin. Organ Transplant. 14: 326-331 (2009).

• Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K, Yajima M, Nakamura H, Katagiri YU, Okita H, Morio T, Shimizu N, Fujimoto J, Fujiwara S. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology 128: 405-419 (2009). *

• Miyahara Y, Odunsi K, Chen W, Peng G, Matsuzaki J, Wang RF. Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc. Natl. Acad. Sci. U.S.A. 105: 15505-15510 (2008). *

• Mo C, Chearwae W, O'Malley JT, Adams SM, Kanakasabai S, Walline CC, Stritesky GL, Good SR, Perumal NB, Kaplan MH, Bright JJ. Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J. Immunol. 181: 5681-5690 (2008). *

• Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC. Ets-1 is a negative regulator of Th17 differentiation. J. Exp. Med. 204: 2825-2835 (2007). *

• Mojibian M, Chakir H, Lefebvre DE, Crookshank JA, Sonier B, Keely E, Scott FW. A diabetes-specific HLA-DR restricted pro-inflammatory T cell response to wheat polypeptides in tissue transglutaminase antibody negative patients with type 1 diabetes. Diabetes 58: 1789-1796 (2009).

• Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN. IL-17 receptor signaling influences virus-induced corneal inflammation. J. Leukoc. Biol. 83: 401-408 (2008). *

• Momcilovic M, Miljkovic Z, Popadic D, Markovic M, Savic E, Ramic Z, Miljkovic D, Mostarica-Stojkovic M. Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells. BMC Immunol. 9: 47 (2008). *

• Momcilovic M, Miljkovic Z, Popadic D, Miljkovic D, Mostarica-Stojkovic M. Kinetics of IFN-gamma and IL-17 expression and production in active experimental autoimmune encephalomyelitis in dark agouti rats. Neurosci. Lett. 447: 148-152 (2008).

• Monari C, Bevilacqua S, Piccioni M, Pericolini E, Perito S, Calvitti M, Bistoni F, Kozel TR, Vecchiarelli A. A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production. J. Immunol. 183: 191-200 (2009).

• Monteiro AC, Schmitz V, Morrot A, de Arruda LB, Nagajyothi F, Granato A, Pesquero JB, Muller-Esterl W, Tanowitz HB, Scharfstein J. Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses. PLoS Pathog. 3: e185 (2007). *

• Monteiro AC, Scovino A, Raposo S, Gaze VM, Cruz C, Svensjo E, Narciso MS, Colombo AP, Pesquero JB, Feres-Filho E, Nguyen KA, Sroka A, Potempa J, Scharfstein J. Kinin danger signals proteolytically released by gingipain induce fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis. J. Immunol. 183: 3700-3711 (2009).

• Monteleone I, Sarra M, Del Vecchio Blanco G, Paoluzi OA, Franze E, Fina D, Fabrizi A, Macdonald TT, Pallone F, Monteleone G. Characterization of IL-17A-producing cells in celiac disease mucosa. J. Immunol. Jan 8 [Epub ahead of print] (2010).

• Montufar-Solis D, Schaefer J, Hicks MJ, Klein JR. Massive but selective cytokine dysregulation in the colon of IL-10-/- mice revealed by multiplex analysis. Int. Immunol. 20: 141-154 (2008). *

• Moore CC, Martin EN, Lee GH, Obrig T, Linden J, Scheld WM. An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine septic shock models. BMC Infect. Dis. 8: 141 (2008). *

• Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, oncostatin M and response to biologic therapies. Arthritis Res. Ther. 11: R113 (2009). *

• Moran JP, Walter J, Tannock GW, Tonkonogy SL, Sartor RB. Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10-deficient mice. Inflamm. Bowel Dis. 15: 1022-1031 (2009).

• Moreland LW, Curtis JR. Systemic nonarticular manifestations of rheumatoid arthritis: focus on inflammatory mechanisms. Semin. Arthritis Rheum. 39: 132-143 (2009). *

• Moschen AR, Geiger S, Krehan I, Kaser A, Tilg H. Interferon-alpha controls IL-17 expression in vitro and in vivo. Immunobiology 213: 779-787 (2008).

• Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14: 155-174 (2003). *

• Moser JM, Sassano ER, Leistritz DC, Eatrides JM, Phogat S, Koff W, Drake DR 3rd. Optimization of a dendritic cell-based assay for the in vitro priming of naive human CD4(+) T cells. J. Immunol. Methods Nov 16 [Epub ahead of print] (2009). *

• Motegi SI, Okazawa H, Murata Y, Kanazawa Y, Saito Y, Kobayashi H, Ohnishi H, Oldenborg PA, Ishikawa O, Matozaki T. Essential roles of SHPS-1 in induction of contact hypersensitivity of skin. Immunol. Lett. 121: 52-60 (2008).

• Mrabet-Dahbi S, Metz M, Dudeck A, Zuberbier T, Maurer M. Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. Exp. Dermatol. 18: 437-444 (2009).

• Mu L, Sun B, Kong Q, Wang J, Wang G, Zhang S, Wang D, Liu Y, Liu Y, An H, Li H. Disequilibrium of Th1, Th2, Th17 and Treg cells during the development of experimental autoimmune myasthenia gravis. Immunology 128: e826-e836 (2009). *

• Mucida D, Cheroutre H. TGFbeta and retinoic acid intersect in immune-regulation. Cell. Adh. Migr. 1: 142-144 (2007). *

• Mucida D, Park Y, Cheroutre H. From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine. Semin. Immunol. 21: 14-21 (2009). *

• Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal Th-17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260 (2007). *

• Mucida D, Salek-Ardakani S. Regulation of TH17 cells in the mucosal surfaces. J. Allergy Clin. Immunol. 123: 997-1003 (2009). *

• Mudter J, Neurath MF. IL-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm. Bowel Dis. 13: 1016-1023 (2007). *

• Mudter J, Yu J, Amoussina L, Weigmann B, Hoffman A, Rucknagel K, Galle PR, Neurath MF. IRF4 selectively controls cytokine gene expression in chronic intestinal inflammation. Arch. Immunol. Ther. Exp. (Warsz.) 57: 369-376 (2009).

• Mueller AM, Pedre X, Killian S, David M, Steinbrecher A. The decoy receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid. J. Neuroimmunol. 209: 57-64 (2009).

• Mueller C, Keeler A, Braag S, Menz T, Tang Q, Flotte TR. Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e. Mol. Ther. Nov 24 [Epub ahead of print] (2009).

• Mukherjee S, Schaller MA, Neupane R, Kunkel SL, Lukacs NW. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J. Immunol. 182: 7381-7388 (2009).

• Muller A, Lamprecht P. Interleukin-17 in chronic inflammatory and autoimmune diseases: rheumatoid arthritis, Crohn's disease and Wegener's granulomatosis. Z. Rheumatol. 67: 72-74 (2008).

• Muller U, Stenzel W, Kohler G, Werner C, Polte T, Hansen G, Schutze N, Straubinger RK, Blessing M, McKenzie AN, Brombacher F, Alber G. IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J. Immunol. 179: 5367-5377 (2007). *

• Munitz A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J. Immunol. 182: 2357-2363 (2009).

• Munoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Holscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J. Exp. Med. 206: 3047-3059 (2009). *

• Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann K, Feigenbaum L, Chan CC, Restifo NP. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112: 362-373 (2008). *

• Muranski P, Restifo NP. Does IL-17 promote tumor growth? Blood 114: 231-232 (2009). *

• Murata M, Fujimoto M, Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Komura K, Sato S. Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease? J. Dermatol. Sci. 50: 240-242 (2008).

• Murphy AC, Lalor SJ, Lynch MA, Mills KH. Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav. Immun. Feb 4 [Epub ahead of print] (2010).

• Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198: 1951-1957 (2003). *

• Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183: 2435-2443 (2009).

• Murugaiyan G, Mittal A, Weiner HL. Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J. Immunol. 181: 7480-7488 (2008). *

• Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J. Immunol. 183: 4169-4175 (2009). *

• Mus AM, Cornelissen F, Asmawidjaja PS, van Hamburg JP, Boon L, Hendriks RW, Lubberts E. IL-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for IL-22 but not IL-21 in autoimmune experimental arthritis. Arthritis Rheum. Jan 21 [Epub ahead of print] (2010). *

• Mustafa A, Holladay SD, Goff M, Witonsky S, Kerr R, Weinstein DA, Karpuzoglu-Belgin E, Gogal RM Jr. Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24-week-old SNF(1) mice. Birth Defects Res. A. Clin. Mol. Teratol. 85: 828-836 (2009).

• Nady S, Ignatz-Hoover J, Shata MT. IL-12 is the optimum cytokine to expand human Th17 cells in vitro. Clin. Vaccine Immunol. 16: 798-805 (2009).

• Nagahama K, Ogawa A, Shirane K, Shimomura Y, Sugimoto K, Mizoguchi A. Protein kinase C theta plays a fundamental role in different types of chronic colitis. Gastroenterology 134: 459-469 (2008). *

• Nagaleekar VK, Diehl SA, Juncadella I, Charland C, Muthusamy N, Eaton S, Haynes L, Garrett-Sinha LA, Anguita J, Rincon M. IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program. J. Immunol. 181: 8315-8322 (2008). *

• Nagasaka S, Iwasaki T, Okano T, Chiba J. Antigen-specific IL-23/17 pathway activation by murine semi-mature DC-like cells. Biochem. Biophys. Res. Commun. 387: 52-57 (2009). *

• Nagata T, McKinley L, Peschon JJ, Alcorn JF, Aujla SJ, Kolls JK. Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells. J. Immunol. 181: 7473-7479 (2008). *

• Nakae S, Iwakura Y, Suto H, Galli SJ. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 81: 1258-1268 (2007). *

• Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17: 375-387 (2002). *

• Nakae S, Lunderius C, Ho LH, Schafer B, Tsai M, Galli SJ. TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice. J. Allergy Clin. Immunol. 119: 680-686 (2007). *

• Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171: 6173-6177 (2003). *

• Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. 100: 5986-5990 (2003). *

• Nakae S, Suto H, Berry GJ, Galli SJ. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109: 3640-3648 (2007). *

• Nakagome K, Okunishi K, Imamura M, Harada H, Matsumoto T, Tanaka R, Miyazaki J, Yamamoto K, Dohi M. IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine. J. Immunol. 183: 209-220 (2009).

• Nakamura R, Shibata K, Yamada H, Shimoda K, Nakayama K, Yoshikai Y. Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T Cells. J. Immunol. 181: 2071-2075 (2008). *

• Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, Matsushita S. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem. Biophys. Res. Commun. 373: 286-291 (2008). *

• Nakashima A, Ito M, Yoneda S, Shiozaki A, Hidaka T, Saito S. Circulating and decidual Th17 cell levels in healthy pregnancy. Am. J. Reprod. Immunol. Dec 15 [Epub ahead of print] (2009).

• Nakashima T, Takayanagi H. The dynamic interplay between osteoclasts and the immune system. Arch. Biochem. Biophys. 473: 166-171 (2008). *

• Nakashima T, Takayanagi H. Osteoimmunology: crosstalk between the immune and bone systems. J. Clin. Immunol. 29: 555-567 (2009). *

• Nalbandian A, Crispín JC, Tsokos BC. IL-17 and systemic lupus erythematosus: current concepts. Clin. Exp. Immunol. 157: 209-215 (2009). *

• Nam JS, Terabe M, Kang MJ, Chae H, Voong N, Yang YA, Laurence A, Michalowska A, Mamura M, Lonning S, Berzofsky JA, Wakefield LM. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 68: 3915-3923 (2008). *

• Nanba T, Watanabe M, Inoue N, Iwatani Y. Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease. Thyroid 19: 495-501 (2009).

• Nanki T. Molecular mechanisms of bone destruction in rheumatoid arthritis. Clin. Calcium 17: 510-516 (2007).

• Napolitani G, Acosta-Rodriguez EV, Lanzavecchia A, Sallusto F. Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4(+) T cells. Eur. J. Immunol. 39: 1301-1312 (2009). *

• Nardelli DT, Burchill MA, England DM, Torrealba J, Callister SM, Schell RF. Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody. Clin. Diagn. Lab. Immunol. 11: 1075-1084 (2004). *

• Nardelli DT, Cloute JP, Luk KH, Torrealba J, Warner TF, Callister SM, Schell RF. CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection. Clin. Diagn. Lab. Immunol. 12: 786-792 (2005). *

• Nardelli DT, Kevin Luk KH, Kotloski NJ, Warner TF, Torrealba JR, Callister SM, Schell RF. Role of IL-17, transforming growth factor-beta, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice. FEMS Immunol. Med. Microbiol. 53: 265-274 (2008). *

• Nardelli DT, Schell RF. Expanded role for interleukin-17 in lyme arthritis: comment on the article by Codolo et al. Arthritis Rheum. 60: 1202 (2009). *

• Narushima S, Dimeo D, Tian J, Zhang J, Liu D, Berg DJ. 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL10-/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G477-G488 (2008). *

• Nataraja S, Kagan D, Clark A, Palmer S. Cytokines and growth factors inhibit tumor necrosis factor alpha-induced up-regulation of fibronectin binding on bovine endometrial cells. Fertil. Steril. 89: S1422-S1429 (2008). *

• Nataraju A, Saini D, Ramachandran S, Benshoff N, Liu W, Chapman W, Mohanakumar T. Oleanolic acid, a plant triterpenoid, significantly improves survival and function of islet allograft. Transplantation 88: 987-994 (2009).

• Nath N, Khan M, Paintlia MK, Hoda MN, Giri S. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J. Immunol. 182: 8005-8014 (2009).

• Nath N, Morinaga O, Singh I. S-Nitrosoglutathione a physiologic nitric oxide carrier attenuates experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. Jan 21 [Epub ahead of print] (2010).

• Naundorf S, Schroder M, Hoflich C, Suman N, Volk HD, Grutz G. IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells. Eur. J. Immunol. 39: 1066-1077 (2009). *

• Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J. Allergy Clin. Immunol. 123: 986-994 (2009). *

• Neurath MF. IL-23: a master regulator in Crohn disease. Nat. Med. 13: 26-28 (2007). *

• Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 182: 5317-5321 (2009).

• Nguyen CQ, Hu MH, Li Y, Stewart C, Peck AB. Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice. Arthritis Rheum. 58: 734-743 (2008). *

• Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology 133: 1188-1197 (2007). *

• Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T. TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses. J. Immunol. 182: 7119-7130 (2009).

• Nicholson LB, Raveney BJ, Munder M. Monocyte dependent regulation of autoimmune inflammation. Curr. Mol. Med. 9: 23-29 (2009).

• Nickoloff BJ. Cracking the cytokine code in psoriasis. Nat. Med. 13: 242-244 (2007). *

• Niedbala W, Cai B, Wei X, Patakas A, Leung BP, McInnes IB, Liew FY. Interleukin-27 attenuates collagen-induced arthritis. Ann. Rheum. Dis. 67: 1474-1479 (2008).

• Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol. 37: 3021-3029 (2007). *

• Nielsen OH, Kirman I, Rudiger N, Hendel J, Vainer B. Upregulation of interleukin-12 and -17 in active inflammatory bowel disease. Scand. J. Gastroenterol. 38: 180-185 (2003). *

• Nieminen K, Valovirta E, Savolainen J. Clinical outcome and IL-17, IL-23, IL-27 and FOXP3 expression in peripheral blood mononuclear cells of pollen-allergic children during sublingual immunotherapy. Pediatr. Allergy Immunol. Jun 29 [Epub ahead of print] (2009). *

• Niess JH, Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J. Immunol. Jan 20 [Epub ahead of print] (2010).

• Niess JH, Leithauser F, Adler G, Reimann J. Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J. Immunol. 180: 559-568 (2008). *

• Nikodemova M, Lee J, Fabry Z, Duncan ID. Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord. J. Neuroimmunol. Jan 19 [Epub ahead of print] (2010).

• Nikoopour E, Schwartz JA, Singh B. Therapeutic benefits of regulating inflammation in autoimmunity. Inflamm. Allergy Drug Targets 7: 203-210 (2008).

• Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702 (2007). *

• Nishiyori A, Nagakura Y, Ichikawa K. Piroxicam accelerates development of colitis in T-cell receptor alpha chain-deficient mice. Eur. J. Pharmacol. 615: 241-245 (2009). *

• Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58: 875-887 (2008). *

• Nistala K, Wedderburn LR. Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. Rheumatology (Oxford) 48: 602-606 (2009).

• Niwa H, Satoh T, Matsushima Y, Hosoya K, Saeki K, Niki T, Hirashima M, Yokozeki H. Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation. Clin. Immunol. 132: 184-194 (2009). *

• Nizri E, Irony-Tur-Sinai M, Faranesh N, Lavon I, Lavi E, Weinstock M, Brenner T. Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. J. Neuroimmunol. 203: 12-22 (2008).

• Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T. Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J. Immunol. 183: 6681-6688 (2009).

• No authors listed. In this issue. Eur. J. Immunol. 39: 919-920 (2009).

• No authors listed. In this issue. Eur. J. Immunol. 39: 628-629 (2009). *

• No authors listed. Trial watch: novel biologic for psoriasis shows superiority over current best-seller. Nat. Rev. Drug Discov. 7: 880-881 (2008). *

• No authors listed. In this issue. Eur. J. Immunol. 40: 6-7 (2009). *

• No authors listed. In this issue. Eur. J. Immunol. 39: 2642-2643 (2009).

• No authors listed. In this issue. Eur. J. Immunol. 39: 2308-2309 (2009). *

• No authors listed. In this issue. Eur. J. Immunol. 40: 310-311 (2010). *

• No authors listed. In this issue. Eur. J. Immunol. 39: 3274-3275 (2009). *

• Nograles KE, Brasington RD, Bowcock AM. New insights into the pathogenesis and genetics of psoriatic arthritis. Nat. Clin. Pract. Rheumatol. 5: 83-91 (2009).

• Nograles KE, Zaba LC, Guttman-Yassky E, Fuentes-Duculan J, Suarez-Farinas M, Cardinale I, Khatcherian A, Gonzalez J, Pierson KC, White TR, Pensabene C, Coats I, Novitskaya I, Lowes MA, Krueger JG. Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br. J. Dermatol. 159: 1092-1102 (2008). *

• Nograles KE, Zaba LC, Shemer A, Fuentes-Duculan J, Cardinale I, Kikuchi T, Ramon M, Bergman R, Krueger JG, Guttman-Yassky E. IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing T(H)17 T cells. J. Allergy Clin. Immunol. 123: 1244-1252.e2 (2009). *

• Noguchi D, Wakita D, Tajima M, Ashino S, Iwakura Y, Zhang Y, Chamoto K, Kitamura H, Nishimura T. Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner. Int. Immunol. 19: 1431-1440 (2007). *

• Nogueira E, Hamour S, Sawant D, Henderson S, Mansfield N, Chavele KM, Pusey CD, Salama AD. Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis. Nephrol. Dial. Transplant. Jan 25 [Epub ahead of print] (2010).

• Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J. Exp. Med. 205: 2491-2497 (2008). *

• Notley CA, McCann FE, Inglis JJ, Williams RO. Anti-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis. Arthritis Rheum. 62: 171-178 (2009). *

• Numasaki M, Tagawa M, Iwata F, Suzuki T, Nakamura A, Okada M, Iwakura Y, Aiba S, Yamaya M. IL-28 elicits antitumor responses against murine fibrosarcoma. J. Immunol. 178: 5086-5098 (2007). *

• Numata I, Okuyama R, Memezawa A, Ito Y, Takeda K, Furuyama K, Shibahara S, Aiba S. Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines. J. Invest. Dermatol. 129: 2594-2603 (2009). *

• Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-484 (2007). *

• Nurieva RI, Dong C. Keeping autoimmunity in check: how to control a Th17 cell controller. Immunity 29: 841-843 (2008). *

• O'Brien R, Jin N, Huang Y, Aydintug MK, Roark C, Born W. Characteristics of IL-17-Producing gammadelta T cells. Immunity 32: 1 (2010). *

• O'Brien RL, Roark CL, Born WK. IL-17-producing gammadelta T cells. Eur. J. Immunol. 39: 662-666 (2009). *

• O'Connor Jr W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat. Immunol. 10: 603-609 (2009). *

• O'Connor RA, Malpass KH, Anderton SM. The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cells. J. Immunol. 179: 958-966 (2007). *

• O'Connor RA, Prendergast CT, Sabatos CA, Lau CW, Leech MD, Wraith DC, Anderton SM. Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181: 3750-3754 (2008). *

• O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, Hogenesch H, Srinivasan M, Kaplan MH. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J. Immunol. 181: 5062-5070 (2008). *

• O'Quinn DB, Palmer MT, Lee YK, Weaver CT. Chapter 5. Emergence of the Th17 pathway and its role in host defense. Adv. Immunol. 99C: 115-163 (2008).

• Oboki K, Ohno T, Saito H, Nakae S. Th17 and allergy. Allergol. Int. 57: 121-134 (2008). *

• Ochoa-Reparaz J, Rynda A, Ascon MA, Yang X, Kochetkova I, Riccardi C, Callis G, Trunkle T, Pascual DW. IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen. J. Immunol. 181: 954-968 (2008). *

• Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J. Allergy Clin. Immunol. 123: 977-983 (2009). *

• Ogawa A, Andoh A, Araki Y, Bamba T, Fujiyama Y. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin. Immunol. 110: 55-62 (2004). *

• Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, Nishihara M, Iwakura Y, Hirano T. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29: 628-636 (2008). *

• Ohsugi Y. Recent advances in IL-6 related to autoimmunity. The Scientist May, 2007 (http://www.the-scientist.com/2007/05/01/s37/1/) (2007).

• Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, Hata M, Yamane J, Terada N. The involvement of IL-23 and the Th17 pathway in periodontitis. J. Dent. Res. 88: 633-638 (2009). *

• Ohyanagi N, Ishido M, Suzuki F, Kaneko K, Kubota T, Miyasaka N, Nanki T. Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo. Arthritis Rheum. 60: 3118-3127 (2009). *

• Okada H, Inoue T, Hashimoto K, Suzuki H, Matsushita S. D1-like receptor antagonist inhibits IL-17 expression and attenuates crescent formation in nephrotoxic serum nephritis. Am. J. Nephrol. 30: 274-279 (2009).

• Okamoto H, Cujec TP, Yamanaka H, Kamatani N. Molecular aspects of rheumatoid arthritis: role of transcription factors. FEBS J. 275: 4463-4470 (2008). *

• Okamoto H, Hoshi D, Kiire A, Yamanaka H, Kamatani N. Molecular targets of rheumatoid arthritis. Inflamm. Allergy Drug Targets 7: 53-66 (2008).

• Oki S, Yamamura T. Identification of a possible therapeutic target through pathogenic T cell analysis of multiple sclerosis. Nihon Rinsho Meneki Gakkai Kaishi 32: 214-222 (2009).

• Okiyama N, Sugihara T, Iwakura Y, Yokozeki H, Miyasaka N, Kohsaka H. Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A. Arthritis Rheum. 60: 2505-2512 (2009). *

• Okunishi K, Dohi M, Fujio K, Nakagome K, Tabata Y, Okasora T, Seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K. Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J. Immunol. 179: 5504-5513 (2007). *

• Olivito B, Simonini G, Ciullini S, Moriondo M, Betti L, Gambineri E, Cantarini L, de Martino M, Azzari C, Cimaz R. Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis. J. Rheumatol. 36: 2017-2024 (2009).

• Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, Sollid LM, Lundin KE. Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. PLoS ONE 4: e5641 (2009). *

• Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, Kumagai I, Kudo T, Ishii N, Tanaka N, Sugamura K, Hayasaka K, Asao H. Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int. Immunol. 19: 1191-1199 (2007).

• Onore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, de Water JV, Ashwood P. Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J. Neuroimmunol. 216: 126-129 (2009).

• Ooi JD, Phoon RK, Holdsworth SR, Kitching AR. IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J. Am. Soc. Nephrol. 20: 980-989 (2009).

• Ordonez L, Bernard I, L'faqihi-Olive FE, Tervaert JW, Damoiseaux J, Saoudi A. CD45RC isoform expression identifies functionally distinct T cell subsets differentially distributed between healthy individuals and AAV patients. PLoS ONE 4: e5287 (2009). *

• Ortega C, Fernandez-A S, Carrillo JM, Romero P, Molina IJ, Moreno JC, Santamaría M. IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J. Leukoc. Biol. 86: 435-443 (2009). *

• Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Chen L, Kroner A, Wiendl H. B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. Eur. J. Immunol. 38: 1734-1744 (2008). *

• Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T. Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators. Int. J. Parasitol. 39: 457-464 (2009).

• Oseko F, Yamamoto T, Akamatsu Y, Kanamura N, Iwakura Y, Imanishi J, Kita M. IL-17 is involved in bone resorption in mouse periapical lesions. Microbiol. Immunol. 53: 287-294 (2009). *

• Osorio F, Leibundgut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis E Sousa C. DC activated via dectin-1 convert Treg into IL-17 producers. Eur. J. Immunol. 38: 3274-3281 (2008). *

• Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Biochem. Biophys. Res. Commun. 382: 252-258 (2009). *

• Ouyang W, Filvaroff E, Hu Y, Grogan J. Novel therapeutic targets along the Th17 pathway. Eur. J. Immunol. 39: 670-675 (2009). *

• Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467 (2008). *

• Ovlisen K, Kristensen AT, Jensen AL, Tranholm M. IL-1 beta, IL-6, KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis. Haemophilia 15: 802-810 (2009). *

• Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J. Exp. Med. 203: 843-849 (2006). *

• Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc. Natl. Acad. Sci. U.S.A. 106: 14954-14959 (2009). *

• Oyoshi MK, Murphy GF, Geha RS. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J. Allergy Clin. Immunol. 124: 485-493.e1 (2009). *

• Paclik D, Danese S, Berndt U, Wiedenmann B, Dignass A, Sturm A. Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle. PLoS ONE 3: e2629 (2008). *

• Pacquelet S, Presle N, Boileau C, Dumond H, Netter P, Martel-Pelletier J, Pelletier JP, Terlain B, Jouzeau JY. Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis. J. Rheumatol. 29: 2602-2610 (2002). *

• Page G, Miossec P. RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes. Arthritis Rheum. 52: 2307-2312 (2005). *

• Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P. Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression. Am. J. Pathol. 164: 409-417 (2004). *

• Paidipally P, Periasamy S, Barnes PF, Dhiman R, Indramohan M, Griffith DE, Cosman D, Vankayalapati R. NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen. J. Immunol. 183: 1940-1945 (2009).

• Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis. Arthritis Rheum. 60: 738-749 (2009). *

• Palmer MT, Weaver CT. Autoimmunity: increasing suspects in the CD4(+) T cell lineup. Nat. Immunol. 11: 36-40 (2010). *

• Pandolfi F, Cianci R, Pagliari D, Landolfi R, Cammarota G. Cellular mediators of inflammation: Tregs and Th17 cells in gastrointestinal diseases. Mediators Inflamm. 2009: 132028 (2009). *

• Pappu BP, Angkasekwinai P, Dong C. Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines. Pharmacol. Ther. 117: 374-384 (2008). *

• Pappu BP, Dong C. Measurement of interleukin-17. Curr. Protoc. Immunol. Chapter 6: Unit 6.25 (2007).

• Pappu R, Ramirez-Carrozzi V, Ota N, Ouyang W, Hu Y. The IL-17 family cytokines in immunity and disease. J. Clin. Immunol. Feb 23 [Epub ahead of print] (2010).

• Paradowska A, Masliniski W, Grzybowska-Kowalczyk A, Lacki J. The function of interleukin 17 in the pathogenesis of rheumatoid arthritis. Arch. Immunol. Ther. Exp. (Warsz.) 55: 329-334 (2007). *

• Paranavitana C, Pittman P, Velauthapillai M, Dasilva L. Temporal cytokine profiling of Francisella tularensis-infected human peripheral blood mononuclear cells. J. Microbiol. Immunol. Infect. 41: 192-199 (2008). *

• Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6: 1133-1141 (2005). *

• Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. J. Immunol. 183: 3259-3267 (2009).

• Park SS, Lillehoj HS, Allen PC, Park DW, FitzCoy S, Bautista DA, Lillehoje EP. Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis. Avian Dis. 52: 14-22 (2008).

• Parsonage G, Filer A, Bik M, Hardie D, Lax S, Howlett K, Church LD, Raza K, Wong SH, Trebilcock E, Scheel-Toellner D, Salmon M, Lord JM, Buckley CD. Prolonged, granulocyte-macrophage-colony stimulating factor dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNF-alpha. Arthritis Res. Ther. 10: R47 (2008). *

• Pasquinelli V, Townsend JC, Jurado JO, Alvarez IB, Quiroga MF, Barnes PF, Samten B, García VE. IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB. J. Infect. Dis. 199: 661-665 (2009). *

• Passos ST, Silver JS, O'Hara AC, Sehy D, Stumhofer JS, Hunter CA. IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Pasztoi M, Nagy G, Geher P, Lakatos T, Toth K, Wellinger K, Pocza P, Gyorgy B, Holub MC, Kittel A, Paloczy K, Mazan M, Nyirkos P, Falus A, Buzas EI. Gene expression and activity of cartilage-degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts. Arthritis Res. Ther. 11: R68 (2009). *

• Patel DN, King CA, Bailey SR, Holt JH, Venkatachalam K, Agrawal A, Valente AJ, Chandrasekar B. Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappa B and C/EBPbeta activation. J. Biol. Chem. 282: 27229-27238 (2007). *

• Patel KD, Murphy RT, White M, Gasparro D, Kelleher DP, Ryan T, McManus R, Ryan AW. Interleukin 17: an unlikely marker of acute coronary syndrome? Atherosclerosis 205: 33-34 (2009).

• Patel S, Chung SH, White G, Bao S, Celermajer DS. The "atheroprotective" mediators apolipoproteinA-I and Foxp3 are over-abundant in unstable carotid plaques. Int. J. Cardiol. May 28 [Epub ahead of print] (2009).

• Paulson ML, Freeman AF, Holland SM. Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3. Curr. Opin. Allergy Clin. Immunol. 8: 527-533 (2008).

• Paunovic V, Carroll HP, Vandenbroeck K, Gadina M. Signalling, inflammation and arthritis: crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity. Rheumatology (Oxford) 47: 771-776 (2008). *

• Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Holscher C, Wolf G, Kurts C, Mittrucker HW, Stahl RA, Panzer U. The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J. Am. Soc. Nephrol. 20: 969-979 (2009).

• Pedersen AE, Gad M, Kristensen NN, Haase C, Nielsen CH, Claesson MH. Tolerogenic dendritic cells pulsed with enterobacterial extract suppress development of colitis in the severe combined immunodeficiency transfer model. Immunology 121: 526-532 (2007). *

• Pei F, Han Y, Zhang X, Yan C, Huang M, Deng J, Kang J. Association analysis of the IL-17F His161Arg polymorphism in myocardial infarction. Coron. Artery Dis. 20: 513-517 (2009).

• Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N, Costantini C, Cosmi L, Lunardi C, Annunziato F, Romagnani S, Cassatella MA. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115: 335-343 (2010). *

• Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 180: 7423-7430 (2008). *

• Peng J, Yang XO, Chang SH, Yang J, Dong C. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res. Nov 24 [Epub ahead of print] (2009).

• Peng MY, Wang ZH, Yao CY, Jiang LN, Jin QL, Wang J, Li BQ. Interleukin 17-producing gammadelta T cells increased in patients with active pulmonary tuberculosis. Cell. Mol. Immunol. 5: 203-208 (2008). *

• Peng Y, Han G, Shao H, Wang Y, Kaplan HJ, Sun D. Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 48: 4153-4161 (2007). *

• Penna G, Amuchastegui S, Cossetti C, Aquilano F, Mariani R, Sanvito F, Doglioni C, Adorini L. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J. Immunol. 177: 8504-8511 (2006). *

• Penna G, Fibbi B, Amuchastegui S, Cossetti C, Aquilano F, Laverny G, Gacci M, Crescioli C, Maggi M, Adorini L. Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation. J. Immunol. 182: 4056-4064 (2009).

• Pepper M, Linehan JL, Pagan AJ, Zell T, Dileepan T, Cleary PP, Jenkins MK. Different routes of bacterial infection induce long-lived T(H)1 memory cells and short-lived T(H)17 cells. Nat. Immunol. 11: 83-90 (2010). *

• Peric M, Koglin S, Dombrowski Y, Gross K, Bradac E, Buchau A, Steinmeyer A, Zugel U, Ruzicka T, Schauber J. Vitamin D analogs differentially control antimicrobial peptide/"alarmin"expression in psoriasis. PLoS One 4: e6340 (2009). *

• Peric M, Koglin S, Kim SM, Morizane S, Besch R, Prinz JC, Ruzicka T, Gallo RL, Schauber J. IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J. Immunol. 181: 8504-8512 (2008). *

• Pernis AB. Th17 cells in rheumatoid arthritis and systemic lupus erythematosus. J. Intern. Med. 265: 644-652 (2009). *

• Perona-Wright G, Jenkins SJ, O'Connor RA, Zienkiewicz D, McSorley HJ, Maizels RM, Anderton SM, Macdonald AS. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J. Immunol. 182: 2808-2815 (2009).

• Perrier C, Thierry AC, Mercenier A, Corthesy B. Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice. Clin. Exp. Allergy Aug 18 [Epub ahead of print] (2009). *

• Peters AT, Kato A, Zhang N, Conley DB, Suh L, Tancowny B, Carter D, Carr T, Radtke M, Hulse KE, Seshadri S, Chandra R, Grammer LC, Harris KE, Kern R, Schleimer RP. Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol. 125: 397-403.e10 (2010). *

• Phipps S, Lam CE, Kaiko GE, Foo SY, Collison A, Mattes J, Barry J, Davidson S, Oreo K, Smith L, Mansell A, Matthaei KI, Foster PS. Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses. Am. J. Respir. Crit. Care Med. 179: 883-893 (2009). *

• Phoon RK, Kitching AR, Odobasic D, Jones LK, Semple TJ, Holdsworth SR. T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. J. Am. Soc. Nephrol. 19: 477-485 (2008). *

• Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, Dekruyff RH, Shore SA, Umetsu DT. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J. Exp. Med. 205: 385-393 (2008). *

• Pickens SR, Volin MV, Mandelin AM 2nd, Kolls JK, Pope RM, Shahrara S. IL-17 contributes to angiogenesis in rheumatoid arthritis. J. Immunol. Feb 19 [Epub ahead of print] (2010).

• Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo CE, Colombo MP. Mast cells counteract regulatory T cell suppression through interleukin-6 and OX40/OX40L axis toward Th17 cell differentiation. Blood 114: 2639-2648 (2009). *

• Pietrzak A, Zalewska A, Chodorowska G, Nockowski P, Michalak-Stoma A, Osemlak P, Krasowska D. Genes and structure of selected cytokines involved in pathogenesis of psoriasis. Folia Histochem. Cytobiol. 46: 11-21 (2008).

• Pilon C, Levast B, Meurens F, Le Vern Y, Kerboeuf D, Salmon H, Velge-Roussel F, Lebranchu Y, Baron C. CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1. Mol. Immunol. 46: 437-447 (2009). *

• Pini M, Fantuzzi G. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J. Leukoc. Biol. Sep 10 [Epub ahead of print] (2009). *

• Pini M, Gove ME, Fayad R, Cabay RJ, Fantuzzi G. Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 KO mice. Am. J. Physiol. Gastrointest. Liver Physiol. 296: G382-G387 (2009). *

• Pinto LG, Cunha TM, Vieira SM, Lemos HP, Verri WA Jr, Cunha FQ, Ferreira SH. IL-17 mediates articular hypernociception in antigen-induced arthritis in mice. Pain Dec 5 [Epub ahead of print] (2009).

• Pitta MG, Romano A, Cabantous S, Henri S, Hammad A, Kouriba B, Argiro L, El Kheir M, Bucheton B, Mary C, El-Safi SH, Dessein A. IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani. J. Clin. Invest. 119: 2379-2387 (2009). *

• Plater-Zyberk C, Joosten LA, Helsen MM, Koenders MI, Baeuerle PA, van den Berg WB. Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model. Ann. Rheum. Dis. 68: 721-728 (2009).

• Plum SM, Park EJ, Strawn SJ, Moore EG, Sidor CF, Fogler WE. Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis. BMC Musculoskelet. Disord. 10: 46 (2009). *

• Podojil JR, Miller SD. Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol. Rev. 229: 337-355 (2009). *

• Poggi A, Catellani S, Musso A, Zocchi MR. Gammadelta T lymphocytes producing IFNgamma and IL-17 in response to Candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation. Curr. Med. Chem. 16: 4743-4749 (2009).

• Pongcharoen S, Niumsup PR, Sanguansermsri D. JEG-3 cell culture supernatants cause reduced interferon-gamma and interleukin-17 production in mixed-lymphocyte reactions. Am. J. Reprod. Immunol. 57: 227-231 (2007). *

• Pongcharoen S, Ritvirool PN, Sanguansermsri D, Chanchan P, Jienmongkol P, Butkhamchot P, Warnnissorn P, Banchuin N, Sirisinha S. Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients. Asian Pac. J. Allergy Immunol. 26: 63-69 (2008).

• Pongcharoen S, Supalap K. Interleukin-17 increased progesterone secretion by JEG-3 human choriocarcinoma cells. Am. J. Reprod. Immunol. 61: 261-264 (2009).

• Popa C, Barrera P, Joosten LA, Riel PL, Kullberg BJ, Meer JW, Netea MG. Cytokine production from stimulated whole blood cultures in rheumatoid arthritis patients treated with various TNF blocking agents. Eur. Cytokine Netw. 20: 88-93 (2009).

• Potzl J, Botteron C, Tausch E, Pedre X, Mueller AM, Mannel DN, Lechner A. Tracing functional antigen-specific CCR6 Th17 cells after vaccination. PLoS ONE 3: e2951 (2008). *

• Pradeep AR, Hadge P, Chowdhry S, Patel S, Happy D. Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease. J. Oral Sci. 51: 261-266 (2009). *

• Prause O, Bossios A, Silverpil E, Ivanov S, Bozinovski S, Vlahos R, Sjostrand M, Anderson GP, Linden A. IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo - effects of anti-inflammatory pharmacotherapy. Pulm. Pharmacol. Ther. 22: 199-207 (2009).

• Priebe GP, Walsh RL, Cederroth TA, Kamei A, Coutinho-Sledge YS, Goldberg JB, Pier GB. IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. J. Immunol. 181: 4965-4975 (2008). *

• Promadej-Lanier N, Hanson DL, Srinivasan P, Luo W, Adams DR, Guenthner PC, Butera S, Otten RA, Kersh EN. Resistance to Simian HIV infection is associated with high plasma interleukin-8, RANTES and eotaxin in a macaque model of repeated virus challenges. J. Acquir. Immune Defic. Syndr. Feb 15 [Epub ahead of print] (2010).

• Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, Cobat A, Ouachee-Chardin M, Toulon A, Bustamante J, Al-Muhsen S, Al-Owain M, Arkwright PD, Costigan C, McConnell V, Cant AJ, Abinun M, Polak M, Bougneres PF, Kumararatne D, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. Feb 1 [Epub ahead of print] (2010). *

• Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D, Xiao J, Lu Y, Giltiay N, Liu J, Kordula T, Zhang QW, Vallance B, Swaidani S, Aronica M, Tuohy VK, Hamilton T, Li X. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat. Immunol. 8: 247-256 (2007). *

• Qin LY, DU WJ, Liu KH, Wang C, Chen SJ. Research on the relationship of intrahepatic expression of IL-17 and liver cirrhosis in chronic hepatitis B patients. Zhonghua Gan Zang Bing Za Zhi 17: 221-222 (2009).

• Qiu CL, Zhao H, Yang GB. Th17 lymphocytes in the peripheral blood of Chinese rhesus macaques(Macaca mulatta) with or without SHIV infection. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 217-220 (2008).

• Qiu Z, Dillen C, Hu J, Verbeke H, Struyf S, Van Damme J, Opdenakker G. Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. Immunobiology 214: 835-842 (2009).

• Quintana A, Muller M, Frausto RF, Ramos R, Getts DR, Sanz E, Hofer MJ, Krauthausen M, King NJ, Hidalgo J, Campbell IL. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. J. Immunol. 183: 2079-2088 (2009).

• Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453: 65-71 (2008). *

• Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J. Immunol. 180: 5167-5171 (2008). *

• Racke MK. Immunopathogenesis of multiple sclerosis. Ann. Indian Acad. Neurol. 12: 215-220 (2009).

• Radaeva TV, Kondratieva EV, Sosunov VV, Majorov KB, Apt A. A human-like TB in genetically susceptible mice followed by the true dormancy in a Cornell-like model. Tuberculosis (Edinb.) 88: 576-585 (2008).

• Radhakrishnan S, Cabrera R, Bruns KM, Van Keulen VP, Hansen MJ, Felts SJ, Pease LR. Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions. PLoS ONE 4: e5373 (2009). *

• Radhakrishnan S, Cabrera R, Schenk EL, Nava-Parada P, Bell MP, Van Keulen VP, Marler RJ, Felts SJ, Pease LR. Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J. Immunol. 181: 3137-3147 (2008). *

• Radosavljevic G, Ljujic B, Jovanovic I, Srzentic Z, Pavlovic S, Zdravkovic N, Milovanovic M, Bankovic D, Knezevic M, Acimovic L, Arsenijevic N. Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma. Neoplasma 57: 135-144 (2010).

• Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum. 50: 3856-3865 (2004). *

• Radstake TR, van Bon L, Broen J, Hussiani A, Hesselstrand R, Wuttge DM, Deng Y, Simms R, Lubberts E, Lafyatis R. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 4: e5903 (2009). *

• Rafei M, Berchiche YA, Birman E, Boivin MN, Young YK, Wu JH, Heveker N, Galipeau J. An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis. J. Immunol. 183: 1759-1766 (2009).

• Rafei M, Birman E, Forner K, Galipeau J. Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis. Mol. Ther. 17: 1799-1803 (2009).

• Rafei M, Campeau PM, Aguilar-Mahecha A, Buchanan M, Williams P, Birman E, Yuan S, Young YK, Boivin MN, Forner K, Basik M, Galipeau J. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J. Immunol. 182: 5994-6002 (2009).

• Rafei M, Campeau PM, Wu JH, Birman E, Forner K, Boivin MN, Galipeau J. Selective inhibition of CCR2 expressing lymphomyeloid cells in experimental autoimmune encephalomyelitis by a GM-CSF-MCP1 fusokine. J. Immunol. 182: 2620-2627 (2009).

• Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Baumler AJ. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5: 476-486 (2009).

• Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter S, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins CL, Adams LG, Baumler AJ. The capsule encoding viaB locus reduces IL-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi. Infect. Immun. 75: 4342-4350 (2007). *

• Raffatellu M, Santos RL, Verhoeven DE, George MD, Wilson RP, Winter SE, Godinez I, Sankaran S, Paixao TA, Gordon MA, Kolls JK, Dandekar S, Baumler AJ. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 14: 421-428 (2008). *

• Rahman S, Gudetta B, Fink J, Granath A, Ashenafi S, Aseffa A, Derbew M, Svensson M, Andersson J, Brighenti SG. Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions. Am. J. Pathol. 174: 2211-2224 (2009). *

• Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J. Invest. Dermatol. 129: 671-681 (2009). *

• Rajagopalan G, Tilahun AY, Asmann YW, David CS. Early gene expression changes induced by the bacterial superantigen, staphylococcal enterotoxin B and its modulation by a proteasome inhibitor. Physiol. Genomics 37: 279-293 (2009). *

• Rajaiah R, Lee DY, Ma Z, Fan AY, Lao L, Fong HH, Berman BM, Moudgil KD. Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. J. Ethnopharmacol. 123: 40-44 (2009).

• Ramaprakash H, Ito T, Standiford TJ, Kunkel SL, Hogaboam CM. Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice. Infect. Immun. 77: 108-119 (2009). *

• Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S. IFN-beta inhibits human Th17 cell differentiation. J. Immunol. 183: 5418-5427 (2009). *

• Ramsey CD, Lazarus R, Camargo CA, Weiss ST, Celedon JC. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. Genes Immun. 6: 236-241 (2005). *

• Rangachari M, Mauermann N, Marty RR, Dirnhofer S, Kurrer MO, Komnenovic V, Penninger JM, Eriksson U. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J. Exp. Med. 203: 2009-2019 (2006). *

• Rao DA, Eid RE, Qin L, Yi T, Kirkiles-Smith NC, Tellides G, Pober JS. Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection. J. Exp. Med. 205: 3145-3158 (2008). *

• Rao DA, Tracey KJ, Pober JS. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J. Immunol. 179: 6536-6546 (2007). *

• Raveney BJ, Copland DA, Dick AD, Nicholson LB. TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J. Immunol. 183: 2321-2329 (2009).

• Raveney BJ, Richards CM, Aknin ML, Copland DA, Burton BR, Kerr EC, Nicholson LB, Williams NA, Dick AD. The B subunit of Escherichia coli heat-labile enterotoxin inhibits Th1 but not Th17 cell responses in established autoimmune uveoretinitis. Invest. Ophthalmol. Vis. Sci. 49: 4008-4017 (2008). *

• Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, Akbar AN, Lord JM, Gordon C, Buckley CD, Salmon M. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7: R784-R795 (2005). *

• Reay J, Kim SH, Lockhart E, Kolls J, Robbins PD. Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response. Cancer Gene Ther. 16: 776-785 (2009).

• Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F. C-C chemokine receptor 6-regulated entry of T(H)-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat. Immunol. 10: 514-523 (2009). *

• Reddy M, Davis C, Wong J, Marsters P, Pendley C, Prabhakar U. Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275. Cell. Immunol. 247: 1-11 (2007). *

• Reich K, Garbe C, Blaschke V, Maurer C, Middel P, Westphal G, Lippert U, Neumann C. Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation. J. Invest. Dermatol. 116: 319-329 (2001). *

• Reinhardt RL, Kang SJ, Liang HE, Locksley RM. T helper cell effector fates - who, how and where? Curr. Opin. Immunol. 18: 271-277 (2006).

• Reinhold D, Bank U, Tager M, Ansorge S, Wrenger S, Thielitz A, Lendeckel U, Faust J, Neubert K, Brocke S. DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis. Front. Biosci. 13: 2356-2363 (2008).

• Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J, Hansen W. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. J. Immunol. 180: 5890-5897 (2008). *

• Reksten TR, Jonsson MV, Szyszko EA, Brun JG, Jonsson R, Brokstad KA. Cytokine and autoantibody profiling related to histopathological features in primary Sjogren's syndrome. Rheumatology (Oxford) 48: 1102-1106 (2009). *

• Requena P, Gonzalez R, Lopez-Posadas R, Abadia-Molina A, Suarez MD, Zarzuelo A, Medina FS, Martinez-Augustin O. The intestinal antiinflammatory agent glycomacropeptide has immunomodulatory actions on rat splenocytes. Biochem. Pharmacol. Feb 20 [Epub ahead of print] (2010).

• Reyner CL, Wagner B, Young JC, Ainsworth DM. Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells from horses susceptible to recurrent airway obstruction. Am. J. Vet. Res. 70: 1277-1283 (2009).

• Ribeiro de Almeida C, Heath H, Krpic S, Dingjan GM, van Hamburg JP, Bergen I, van de Nobelen S, Sleutels F, Grosveld F, Galjart N, Hendriks RW. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J. Immunol. 182: 999-1010 (2009).

• Ribot JC, Debarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B. CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat. Immunol. 10: 427-436 (2009). *

• Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol. 181: 4299-4310 (2008). *

• Ridwan R, Kiptoo P, Kobayashi N, Weir S, Hughes M, Williams T, Soegianto R, Siahaan TJ. Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics. J. Pharmacol. Exp. Ther. Dec 21 [Epub ahead of print] (2009). *

• Rifas L. T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization. J. Cell. Biochem. 98: 706-714 (2006). *

• Rifas L, Arackal S. T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism. Arthritis Rheum. 48: 993-1001 (2003). *

• Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gammadelta T cells. J. Immunol. 179: 5576-5583 (2007). *

• Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL. gammadelta T cells: an important source of IL-17. Curr. Opin. Immunol. 20: 353-357 (2008). *

• Roberts S, Gueguen Y, de Lorgeril J, Goetz F. Rapid accumulation of an interleukin 17 homolog transcript in Crassostrea gigas hemocytes following bacterial exposure. Dev. Comp. Immunol. 32: 1099-1104 (2008).

• Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, GroB O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis E Sousa C. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 206: 2037-2051 (2009). *

• Roelofs MF, Wenink MH, Brentano F, Abdollahi-Roodsaz S, Oppers-Walgreen B, Barrera P, van Riel PL, Joosten LA, Kyburz D, van den Berg WB, Radstake TR. Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4 mediated synovial inflammation in rheumatoid arthritis (RA). Ann. Rheum. Dis. 68: 1486-1493 (2009).

• Rohn TA, Jennings GT, Hernandez M, Grest P, Beck M, Zou Y, Kopf M, Bachmann MF. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 36: 2857-2867 (2006). *

• Rojo JM, Pini E, Ojeda G, Bello R, Dong C, Flavell RA, Dianzani U, Portoles P. CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo' Int. Immunol. 20: 577-589 (2008).

• Romagnani S. Human Th17 cells. Arthritis Res. Ther. 10: 206 (2008). *

• Romagnani S, Maggi E, Liotta F, Cosmi L, Annunziato F. Properties and origin of human Th17 cells. Mol. Immunol. 47: 3-7 (2009). *

• Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, Vacca C, Bistoni F, Fioretti MC, Grohmann U, Segal BH, Puccetti P. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451: 211-215 (2008). *

• Romani L, Zelante T, De Luca A, Fallarino F, Puccetti P. IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. J. Immunol. 180: 5157-5162 (2008). *

• Rong Z, Cheng L, Ren Y, Li Z, Li Y, Li X, Li H, Fu XY, Chang Z. Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. Cell. Signal. 19: 1514-1520 (2007). *

• Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res. 19: 208-215 (2009).

• Rosa JS, Oliver SR, Flores RL, Graf SC, Pontello AM, Lbardolaza M, Zaldivar FP, Galassetti PR. Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. J. Pediatr. Endocrinol. Metab. 20: 1293-1305 (2007).

• Rosa JS, Oliver SR, Mitsuhashi M, Flores RL, Pontello AM, Zaldivar FP, Galassetti PR. Altered kinetics of interleukin-6 and other inflammatory mediators during exercise in children with type 1 diabetes. J. Investig. Med. 56: 701-713 (2008).

• Roses RE, Xu S, Xu M, Koldovsky U, Koski G, Czerniecki BJ. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. J. Immunol. 181: 5120-5127 (2008). *

• Roussel L, Rousseau S. IL-17 primes airway epithelial cells lacking functional cystic fibrosis transmembrane conductance regulator (CFTR) to increase NOD1 responses. Biochem. Biophys. Res. Commun. Nov 19 [Epub ahead of print] (2009). *

• Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles C, Rampton DS, Corazza GR, Monteleone G, Di Sabatino A, MacDonald TT. Differential regulation of interleukin-17 and interferon-gamma production in inflammatory bowel disease. Gut 58: 1629-1636 (2009). *

• Roviezzo F, D'Agostino B, Brancaleone V, De Gruttola L, Bucci M, De Dominicis G, Orlotti D, D'Aiuto E, De Palma R, Rossi F, Sorrentino R, Cirino G. Systemic administration of sphingosine-1-phosphate increases bronchial hyper-responsiveness in the mouse. Am. J. Respir. Cell. Mol. Biol. Jun 25 [Epub ahead of print] (2009). *

• Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. J. Immunol. 181: 4485-4494 (2008). *

• Roy LD, Pathangey LB, Tinder TL, Schettini JL, Gruber HE, Mukherjee P. Breast cancer-associated metastasis is significantly increased in a model of autoimmune arthritis. Breast Cancer Res. 11: R56 (2009). *

• Ruber M, Andersson M, Petersson BF, Olaison G, Andersson RE, Ekerfelt C. Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis. Surgery Nov 4 [Epub ahead of print] (2009). *

• Ruddle NH, Akirav EM. Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response. J. Immunol. 183: 2205-2212 (2009).

• Ruddy MJ, Shen F, Smith JB, Sharma A, Gaffen SL. Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment. J. Leukoc. Biol. 76: 135-144 (2004). *

• Rudner XL, Happel KI, Young EA, Shellito JE. The IL-23/IL-17 cytokine axis in murine Pneumocystis infection. Infect. Immun. 75: 3055-3061 (2007). *

• Rueda B, Broen J, Torres O, Simeon C, Ortega-Centeno N, Schrijvenaars MM, Vonk MC, Fonollosa V, van den Hoogen FH, Coenen MJ, Sanchez-Román J, Aguirre-Zamorano MA, García-Portales R, Pros A, Camps MT, Gonzalez-Gay M, Martin J, Radstake TR. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype. Ann. Rheum. Dis. 68: 253-256 (2009).

• Rutitzky LI, Bazzone L, Shainheit MG, Joyce-Shaikh B, Cua DJ, Stadecker MJ. IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17. J. Immunol. 180: 2486-2495 (2008). *

• Rutitzky LI, Smith PM, Stadecker MJ. T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation. Eur. J. Immunol. 39: 2470-2481 (2009). *

• Rutitzky LI, Stadecker MJ. CD4 T cells producing pro-inflammatory interleukin-17 mediate high pathology in schistosomiasis. Mem. Inst. Oswaldo Cruz. 101: 327-330 (2006). *

• Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG. Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice. Inflamm. Bowel Dis. 15: 491-500 (2009).

• Ryan AW, Thornton JM, Brophy K, Daly JS, McLoughlin RM, O'Morain C, Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. Tissue Antigens 65: 150-155 (2005). *

• Rynda A, Maddaloni M, Mierzejewska D, Ochoa-Reparaz J, Maslanka T, Crist K, Riccardi C, Barszczewska B, Fujihashi K, McGhee JR, Pascual DW. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein {sigma}1. J. Immunol. 180: 5187-5200 (2008). *

• Ryu S, Lee JH, Kim SI. IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes. Clin. Rheumatol. 25: 16-20 (2006). *

• Sa-Nunes A, Bafica A, Antonelli LR, Choi EY, Francischetti IM, Andersen JF, Shi GP, Chavakis T, Ribeiro JM, Kotsyfakis M. The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity. J. Immunol. 182: 7422-7429 (2009).

• Saban MR, Simpson C, Davis CA, Wallis G, Knowlton N, Frank MB, Centola M, Gallucci RM, Saban R. Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunol. 8: 6 (2007). *

• Sabatino JJ Jr, Shires J, Altman JD, Ford ML, Evavold BD. Loss of IFN-gamma enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen. J. Immunol. 180: 4451-4457 (2008). *

• Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G. Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation 88: 1109-1116 (2009).

• Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A. A major lipid raft protein raftlin modulates T cell receptor signaling and enhances Th17-mediated autoimmune responses. J. Immunol. 182: 5929-5937 (2009).

• Saidenberg Kermanac'h N, Bessis N, Cohen-Solal M, De Vernejoul MC, Boissier MC. Osteoprotegerin and inflammation. Eur. Cytokine Netw. 13: 144-153 (2002).

• Saito H, Tsurikisawa N, Tsuburai T, Oshikata C, Akiyama K. Cytokine production profile of CD4+ T cells from patients with active Churg-Strauss syndrome tends toward Th17. Int. Arch. Allergy Immunol. 149 Suppl. 1: 61-65 (2009).

• Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J. Immunol. 181: 2898-2906 (2008). *

• Sakai M, Yamashita K, Takemoto N, Ohshima Y, Tsukimoto M, Shinkai Y, Takeda K, Oshio S, Kojima S. Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) induced by methyl-bovine serum albumin (mBSA) in mice. J. Toxicol. Sci. 34: 483-492 (2009). *

• Sakuraba A, Sato T, Kamada N, Kitazume M, Sugita A, Hibi T. Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease. Gastroenterology 137: 1736-1745 (2009). *

• Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM. Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. J. Immunol. 182: 4328-4338 (2009).

• Saleh A, Shan L, Halayko AJ, Kung S, Gounni AS. Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway smooth muscle cells. J. Immunol. 182: 3357-3365 (2009).

• Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J. Immunol. 175: 7635-7641 (2005). *

• Sallusto F, Lanzavecchia A. Human Th17 cells in infection and autoimmunity. Microbes Infect. 11: 620-624 (2009). *

• Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11: 76-83 (2010). *

• Samten B, Wang X, Barnes PF. Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses. Tuberculosis (Edinb.) 89 Suppl. 1: S74-S76 (2009).

• San Segundo D, Lopez-Hoyos M, Fernandez-Fresnedo G, Benito MJ, Ruiz JC, Benito A, Rodrigo E, Arias M. T(H)17 versus Treg cells in renal transplant candidates: effect of a previous transplant. Transplant. Proc. 40: 2885-2888 (2008). *

• Santarlasci V, Maggi L, Capone M, Frosali F, Querci V, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F. TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur. J. Immunol. 39: 207-215 (2009). *

• Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, Nanan R. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J. Immunol. 183: 7023-7030 (2009). *

• Santos RL, Raffatellu M, Bevins CL, Adams LG, Tukel C, Tsolis RM, Baumler AJ. Life in the inflamed intestine, Salmonella style. Trends Microbiol. 17: 498-506 (2009). *

• Sanvito L, Makowska A, Mahdi-Rogers M, Hadden RD, Peakman M, Gregson N, Nemni R, Hughes RA. Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy. J. Neurol. Neurosurg. Psychiatry 80: 333-338 (2009).

• Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int. Arch. Allergy Immunol. 152: 75-80 (2009).

• Sargentini V, Mariotti S, Carrara S, Gagliardi MC, Teloni R, Goletti D, Nisini R. Cytometric detection of antigen-specific IFN-gamma/IL-2 secreting cells in the diagnosis of tuberculosis. BMC Infect. Dis. 9: 99 (2009). *

• Sarkar S, Cooney LA, Fox DA. The role of T helper type 17 cells in inflammatory arthritis. Clin. Exp. Immunol. Aug 25 [Epub ahead of print] (2009). *

• Sarkar S, Cooney LA, White P, Dunlop DB, Endres J, Jorns JM, Wasco MJ, Fox DA. Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. Arthritis Res. Ther. 11: R158 (2009). *

• Sarkar S, Tesmer LA, Hindnavis V, Endres JL, Fox DA. Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4. Arthritis Rheum. 56: 89-100 (2007). *

• Sarra M, Monteleone I, Stolfi C, Fantini MC, Sileri P, Sica G, Tersigni R, Macdonald TT, Pallone F, Monteleone G. Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm. Bowel Dis. Feb 23 [Epub ahead of print] (2010). *

• Saruhan-Direskeneli G, Yentur SP, Akman-Demir G, Isik N, Serdaroglu P. Cytokines and chemokines in neuro-Behcet's disease compared to multiple sclerosis and other neurological diseases. J. Neuroimmunol. 145: 127-134 (2003).

• Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J. Immunol. 178: 3293-3300 (2007). *

• Sato A, Watanabe K, Kaneko K, Murakami Y, Ishido M, Miyasaka N, Nanki T. The effect of synthetic retinoid, Am80, on T helper cell development and antibody production in murine collagen-induced arthritis. Mod. Rheumatol. Dec 29 [Epub ahead of print] (2009). *

• Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203: 2673-2682 (2006). *

• Sato K, Takayanagi H. Regulation of osteoclastogenesis by activated T cells. Nippon Rinsho 63: 1529-1532 (2005).

• Sato T, Kusaka S, Shimojo H, Fujikado T. Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. Ophthalmology 116: 2165-2169 (2009).

• Sato W, Aranami T, Yamamura T. Cutting edge: human Th17 cells are identified as bearing CCR2+CCR5- phenotype. J. Immunol. 178: 7525-7529 (2007). *

• Satpute SR, Durai M, Moudgil KD. Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis. Semin. Arthritis Rheum. 38: 195-207 (2008). *

• Satpute SR, Rajaiah R, Polumuri SK, Moudgil KD. Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses. Arthritis Rheum. 60: 103-113 (2009). *

• Saunus JM, Kazoullis A, Farah CS. Cellular and molecular mechanisms of resistance to oral Candida albicans infections. Front. Biosci. 13: 5345-5358 (2008).

• Sawalha AH. Epigenetics and T-cell immunity. Autoimmunity 41: 245-252 (2008).

• Schaefer JS, Montufar-Solis D, Vigneswaran N, Klein JR. ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice. J. Leukoc. Biol. Nov 4 [Epub ahead of print] (2009). *

• Schambach F, Schupp M, Lazar MA, Reiner SL. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur. J. Immunol. 37: 2396-2399 (2007). *

• Schetter AJ, Nguyen GH, Bowman ED, Mathe EA, Yuen ST, Hawkes JE, Croce CM, Leung SY, Harris CC. Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin. Cancer Res. 15: 5878-5887 (2009). *

• Schiffrin EL. T lymphocytes: a role in hypertension? Curr. Opin. Nephrol. Hypertens. Oct 21 [Epub ahead of print] (2009).

• Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Goke B, Brand S. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm. Bowel Dis. 14: 204-212 (2008). *

• Schmidt-Weber CB, Akdis M, Akdis CA. T(H)17 cells in the big picture of immunology. J. Allergy Clin. Immunol. 120: 247-254 (2007). *

• Schnyder B, Schnyder-Candrian S, Pansky A, Schmitz ML, Heim M, Ryffel B, Moser R. IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine 31: 191-202 (2005).

• Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203: 2715-2725 (2006). *

• Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M. Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. PLoS. Pathog. 5: e1000543 (2009). *

• Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 460: 405-409 (2009). *

• Schreiber TH, Deyev VV, Rosenblatt JD, Podack ER. Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination. Cancer Res. 69: 2026-2033 (2009). *

• Schreiner B, Bailey SL, Shin T, Chen L, Miller SD. PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. Eur. J. Immunol. 38: 2706-2717 (2008). *

• Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. J. Immunol. Dec 18 [Epub ahead of print] (2009).

• Schulz SM, Kohler G, Holscher C, Iwakura Y, Alber G. IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. Int. Immunol. 20: 1129-1138 (2008).

• Schulz SM, Kohler G, Schutze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Muller U, Kastelein RA, Alber G. Protective immunity to systemic infection with attenuated Salmonella enterica serovar Enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J. Immunol. 181: 7891-7901 (2008). *

• Schwandner R, Yamaguchi K, Cao Z. Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J. Exp. Med. 191: 1233-1240 (2000). *

• Schwartz S, Beaulieu JF, Ruemmele FM. Interleukin-17 is a potent immuno-modulator and regulator of normal human intestinal epithelial cell growth. Biochem. Biophys. Res. Commun. 337: 505-509 (2005). *

• Scott Algood HM, Gallo-Romero J, Wilson KT, Peek RM Jr, Cover TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol. Med. Microbiol. 51: 577-586 (2007). *

• Scriba TJ, Kalsdorf B, Abrahams DA, Isaacs F, Hofmeister J, Black G, Hassan HY, Wilkinson RJ, Walzl G, Gelderbloem SJ, Mahomed H, Hussey GD, Hanekom WA. Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J. Immunol. 180: 1962-1970 (2008). *

• Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Isaacs F, Keyser A, Moyo S, Brittain N, Lawrie A, Gelderbloem S, Veldsman A, Hatherill M, Hawkridge A, Hill AV, Hussey GD, Mahomed H, McShane H, Hanekom WA. Modified vaccinia ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4(+) T cells. Eur. J. Immunol. Dec 16 [Epub ahead of print] (2009). *

• Sebkova L, Pellicano A, Monteleone G, Grazioli B, Guarnieri G, Imeneo M, Pallone F, Luzza F. Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect. Immun. 72: 5019-5026 (2004). *

• Segal BM. Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS. Eur. J. Immunol. 39: 1713-1715 (2009). *

• Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, Pfennig S, Jurgens M, Schmechel S, Konrad A, Goke B, Ochsenkuhn T, Muller-Myhsok B, Lohse P, Brand S. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm. Bowel Dis. 14: 437-445 (2008). *

• Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 127: 78-88 (2008). *

• Seko Y, Cole S, Kasprzak W, Shapiro BA, Ragheb JA. The role of cytokine mRNA stability in the pathogenesis of autoimmune disease. Autoimmun. Rev. 5: 299-305 (2006).

• Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A. Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol. Jan 20 [Epub ahead of print] (2010).

• Selvaraj RK, Geiger TL. Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J. Immunol. 180: 2830-2838 (2008). *

• Semik-Orzech A, Barczyk A, Pierzchala W. The role of interleukin 17 cytokine family in inducing allergic inflammation in the pulmonary tract. Pneumonol. Alergol. Pol. 74: 409-413 (2006).

• Semik-Orzech A, Barczyk A, Wiaderkiewicz R, Pierzchala W. Interleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge. Ann. Allergy Asthma Immunol. 103: 418-424 (2009).

• Sender LY, Gibbert K, Suezer Y, Radeke HH, Kalinke U, Waibler Z. CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals. Mol. Immunol. Jan 11 [Epub ahead of print] (2010). *

• Senolt L, Vencovsky J, Pavelka K, Ospelt C, Gay S. Prospective new biological therapies for rheumatoid arthritis. Autoimmun. Rev. 9: 102-107 (2009).

• Seow HF. Pathogen interactions with cytokines and host defence: an overview. Vet. Immunol. Immunopathol. 63: 139-148 (1998).

• Sergejeva S, Linden A. Impact of IL-17 on cells of the monocyte lineage in health and disease. Endocr. Metab. Immune Disord. Drug Targets 9: 178-186 (2009).

• Sfanos KS, Bruno TC, Maris CH, Xu L, Thoburn CJ, Demarzo AM, Meeker AK, Isaacs WB, Drake CG. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin. Cancer Res. 14: 3254-3261 (2008). *

• Sgouroudis E, Albanese A, Piccirillo CA. Impact of protective IL-2 allelic variants on CD4+Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J. Immunol. 181: 6283-6292 (2008). *

• Shahrara S, Huang Q, Mandelin AM, Pope RM. TH-17 cells in rheumatoid arthritis. Arthritis Res. Ther. 10: R93 (2008). *

• Shahrara S, Pickens SR, Dorfleutner A, Pope RM. IL-17 induces monocyte migration in rheumatoid arthritis. J. Immunol. 182: 3884-3891 (2009).

• Shainheit MG, Saraceno R, Bazzone LE, Rutitzky LI, Stadecker MJ. Disruption of IL-27 signaling results in impaired IFN-gamma production but does not significantly affect immunopathology in murine schistosome infection. Infect. Immun. 75: 3169-3177 (2007). *

• Shainheit MG, Smith PM, Bazzone LE, Wang AC, Rutitzky LI, Stadecker MJ. Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology. J. Immunol. 181: 8559-8567 (2008). *

• Shale M, Kaplan GG, Panaccione R, Ghosh S. Isotretinoin and intestinal inflammation: what gastroenterologists need to know. Gut 58: 737-741 (2009). *

• Shalom-Barak T, Quach J, Lotz M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J. Biol. Chem. 273: 27467-27473 (1998). *

• Shamji MF, Allen KD, So S, Jing L, Adams SB Jr, Schuh R, Huebner J, Kraus VB, Friedman AH, Setton LA, Richardson WJ. Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. Spine 34: 648-654 (2009).

• Shao XS, Yang XQ, Zhao XD, Li Q, Xie YY, Wang XG, Wang M, Zhang W. The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome. Pediatr. Nephrol. 24: 1683-1690 (2009).

• Sharma AK, Laubach VE, Ramos SI, Zhao Y, Stukenborg G, Linden J, Kron IL, Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. Nov 10 [Epub ahead of print] (2009).

• Sharp AJ, Polak PE, Simonini V, Lin SX, Richardson JC, Bongarzone ER, Feinstein DL. P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis. J. Neuroinflammation 5: 33 (2008). *

• Sheibanie AF, Khayrullina T, Safadi FF, Ganea D. Prostaglandin E(2) exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. Arthritis Rheum. 56: 2608-2619 (2007). *

• Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D. Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J. 18: 1318-1320 (2004). *

• Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23->IL-17 axis. J. Immunol. 178: 8138-8147 (2007). *

• Shen F, Gaffen SL. Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine 41: 92-104 (2008).

• Shen F, Hu Z, Goswami J, Gaffen SL. Identification of common transcriptional regulatory elements in interleukin-17 target genes. J. Biol. Chem. 281: 24138-24348 (2006). *

• Shen F, Li N, Gade P, Kalvakolanu DV, Weibley T, Doble B, Woodgett JR, Wood TD, Gaffen SL. IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci. Signal. 2: ra8 (2009). *

• Shen F, Ruddy MJ, Plamondon P, Gaffen SL. Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J. Leukoc. Biol. 77: 388-399 (2005). *

• Shen H, Goodall JC, Hill Gaston JS. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 60: 1647-1656 (2009). *

• Shen W, Durum SK. Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease. Neurochem. Res. Nov 14 [Epub ahead of print] (2009). *

• Shi B, Wang Z, Jin H, Chen YW, Wang Q, Qian Y. Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice. Int. Immunopharmacol. 9: 582-586 (2009).

• Shi G, Cox CA, Vistica BP, Tan C, Wawrousek EF, Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J. Immunol. 181: 7205-7213 (2008). *

• Shi J, Fan Y, Xu R, Zuo K, Cheng L, Xu G, Li H. Characterizing T-cell phenotypes in nasal polyposis in Chinese patients. J. Investig. Allergol. Clin. Immunol. 19: 276-282 (2009). *

• Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem. 275: 19167-19176 (2000). *

• Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J. Immunol. 178: 4466-4472 (2007). *

• Shibata K, Yamada H, Nakamura R, Sun X, Itsumi M, Yoshikai Y. Identification of CD25+ gammadelta T cells as fetal thymus-derived naturally occurring IL-17 producers. J. Immunol. 181: 5940-5947 (2008). *

• Shibata S, Saeki H, Tsunemi Y, Kato T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K. IL-17F single nucleotide polymorphism is not associated with psoriasis vulgaris or atopic dermatitis in the Japanese population. J. Dermatol. Sci. 53: 163-165 (2009).

• Shibata T, Tahara T, Hirata I, Arisawa T. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. Hum. Immunol. 70: 547-551 (2009).

• Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat. Med. 15: 946-950 (2009). *

• Shih DQ, Targan SR, McGovern D. Recent advances in IBD pathogenesis: genetics and immunobiology. Curr. Gastroenterol. Rep. 10: 568-575 (2008).

• Shim J, Byun HO, Lee YD, Lee ES, Sohn S. Interleukin-6 small interfering RNA improved the herpes simplex virus-induced systemic inflammation in vivo Behcet's disease-like mouse model. Gene Ther. 16: 415-425 (2009).

• Shimada M, Andoh A, Hata K, Tasaki K, Araki Y, Fujiyama Y, Bamba T. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. J. Immunol. 168: 861-868 (2002). *

• Shimamura M, Huang YY, Kobayashi M, Goji H. Altered production of immunoregulatory cytokines by invariant Valpha19 TCR-bearing cells dependent on the duration and intensity of TCR engagement. Int. Immunol. 21: 179-185 (2009).

• Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J. Immunol. 180: 7175-7183 (2008). *

• Shimozato O, Ugai S, Chiyo M, Takenobu H, Nagakawa H, Wada A, Kawamura K, Yamamoto H, Tagawa M. The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects. Immunology 117: 22-28 (2006). *

• Shimura C, Satoh T, Igawa K, Aritake K, Urade Y, Nakamura M, Yokozeki H. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am. J. Pathol. Dec 14 [Epub ahead of print] (2009). *

• Shin HC, Benbernou N, Fekkar H, Esnault S, Guenounou M. Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine 10: 841-850 (1998).

• Shin JH, Shin DW, Noh M. Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochem. Pharmacol. 77: 1835-1844 (2009). *

• Shinohara ML, Kim JH, Garcia VA, Cantor H. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29: 68-78 (2008). *

• Shiomi S, Toriie A, Imamura S, Konishi H, Mitsufuji S, Iwakura Y, Yamaoka Y, Ota H, Yamamoto T, Imanishi J, Kita M. IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model. Helicobacter 13: 518-524 (2008). *

• Sibilia J, Sordet C, Mrabet D, Wachsmann D. Understanding rheumatoid arthritis. Rev. Prat. 55: 2134-2142 (2005).

• Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol. 21: 555-565 (2009).

• Sieve AN, Meeks KD, Bodhankar S, Lee S, Kolls JK, Simecka JW, Berg RE. A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection. Eur. J. Immunol. 39: 426-438 (2009). *

• Sigal LH. Basic science for the clinician 34: interleukins of current clinical relevance (part II). J. Clin. Rheumatol. 11: 34-39 (2005).

• Silva ML, Espírito-Santo LR, Martins MA, Silveira-Lemos D, Peruhype-Magalhaes V, Caminha RC, de Andrade Maranhao-Filho P, Martins MA, de Menezes Martins R, Galler R, Freire MD, Marcovistz R, Homma A, Teuwen DE, Eloi-Santos SM, Andrade MC, et al. Clinical and immunological insights on severe adverse neurotropic/viscerotropic disease following 17D yellow fever vaccination. Clin. Vaccine Immunol. Nov 11 [Epub ahead of print] (2009). *

• Silva MT. Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens. J. Leukoc. Biol. Jan 28 [Epub ahead of print] (2010). *

• Simelyte E, Criado G, Essex D, Uger RA, Feldmann M, Williams RO. CD200-FC, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis. Arthritis Rheum. 58: 1038-1043 (2008). *

• Simonian PL, Roark CL, Wehrmann F, Lanham AK, Diaz Del Valle F, Born WK, O'Brien RL, Fontenot AP. Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J. Immunol. 182: 657-665 (2009). *

• Simonian PL, Roark CL, Wehrmann F, Lanham AM, Born WK, O'Brien RL, Fontenot AP. IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis. J. Immunol. 182: 6540-6549 (2009).

• Singh MP, Horste GM, Hu W, Mausberg A, Cravens P, Eager TN, Lober S, Klingenstein R, Gmeiner P, Korth C, Kieseier BC, Stuve O. A novel class of immunosuppressive compounds effective in brain autoimmune disease. Exp. Neurol. 215: 397-400 (2009).

• Singh R, Aggarwal A, Misra R. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J. Rheumatol. 34: 2285-2290 (2007). *

• Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 180: 214-221 (2008). *

• Sinha S, Subramanian S, Miller L, Proctor TM, Roberts C, Burrows GG, Vandenbark AA, Offner H. Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand. J. Neurosci. 29: 3816-3823 (2009).

• Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H. A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS. J. Neurosci. 27: 12531-12539 (2007). *

• Sivick KE, Schaller MA, Smith SN, Mobley HL. The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection. J. Immunol. Jan 18 [Epub ahead of print] (2010).

• Skarica M, Wang T, McCadden E, Kardian D, Calabresi PA, Small D, Whartenby KA. Signal transduction inhibition of APCs diminishes Th17 and Th1 responses in experimental autoimmune encephalomyelitis. J. Immunol. 182: 4192-4199 (2009).

• Sklavos MM, Tse HM, Piganelli JD. Redox modulation inhibits CD8 T cell effector function. Free Radic. Biol. Med. 45: 1477-1486 (2008).

• Smith E, Stark MA, Zarbock A, Burcin TL, Bruce AC, Vaswani D, Foley P, Ley K. IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. J. Immunol. 181: 1357-1364 (2008). *

• Smith E, von Vietinghoff S, Stark MA, Zarbock A, Sanders JM, Duley A, Rivera-Nieves J, Bender TP, Ley K. T-Lineage cells require the thymus but not V(D)J recombination to produce IL-17A and regulate granulopoiesis in vivo. J. Immunol. 183: 5685-5693 (2009).

• Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J. Immunol. 179: 8274-8279 (2007). *

• Smith PM, Shainheit MG, Bazzone LE, Rutitzky LI, Poltorak A, Stadecker MJ. Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis. J. Immunol. 183: 3317-3323 (2009).

• So JS, Kwon HK, Lee CG, Yi HJ, Park JA, Lim SY, Hwang KC, Jeon YH, Im SH. Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions. Mol. Immunol. 45: 2690-2699 (2008). *

• So JS, Lee CG, Kwon HK, Yi HJ, Chae CS, Park JA, Hwang KC, Im SH. Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis. Mol. Immunol. 46: 172-180 (2008). *

• Sofi MH, Liu Z, Zhu L, Yu Q, Kaplan MH, Chang CH. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol. Immunol. Jan 15 [Epub ahead of print] (2010). *

• Soleimani A, Berntsen A, Svane IM, Pedersen AE. Immune responses in patients with metastatic renal cell carcinoma treated with dendritic cells pulsed with tumor lysate. Scand. J. Immunol. 70: 481-489 (2009). *

• Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER. The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J. Pharmacol. Exp. Ther. 330: 864-875 (2009). *

• Sonderegger I, Iezzi G, Maier R, Schmitz N, Kurrer M, Kopf M. GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J. Exp. Med. 205: 2281-2294 (2008). *

• Sonderegger I, Kisielow J, Meier R, King C, Kopf M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 38: 1833-1838 (2008). *

• Sonderegger I, Rohn TA, Kurrer MO, Iezzi G, Zou Y, Kastelein RA, Bachmann MF, Kopf M. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur. J. Immunol. 36: 2849-2856 (2006). *

• Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, Li D, Zhang G, Huang B, Feng ZH. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J. Immunol. 181: 6117-6124 (2008). *

• Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal. Chem. Dec 14 [Epub ahead of print] (2009). *

• Sonobe Y, Jin S, Wang J, Kawanokuchi J, Takeuchi H, Mizuno T, Suzumura A. Chronological changes of CD4(+) and CD8(+) T cell subsets in the experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Tohoku J. Exp. Med. 213: 329-339 (2007). *

• Sonobe Y, Liang J, Jin S, Zhang G, Takeuchi H, Mizuno T, Suzumura A. Microglia express a functional receptor for interleukin-23. Biochem. Biophys. Res. Commun. 370: 129-133 (2008). *

• Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, Mimuro M, Hashizume Y, Sano Y, Kanda T, Mizuno T, Suzumura A. Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase C{epsilon}-dependent manner. J. Biol. Chem. 284: 31834-31842 (2009). *

• Sonoda KH. The association of ocular inflammation and innate immune response. Nippon Ganka Gakkai Zasshi 112: 279-297 (2008).

• Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, Hougaard D, Shankaran S, Carlo W; On behalf of the NICHD Neonatal Research Network. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatr. Res. Dec 21 [Epub ahead of print] (2009).

• Soroosh P, Doherty TA. Th9 and allergic disease. Immunology 127: 450-458 (2009). *

• Southam L, Heath O, Chapman K, Loughlin J. Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Ann. Rheum. Dis. 65: 556-557 (2006). *

• Spahn TW, Ross M, von Eiff C, Maaser C, Spieker T, Kannengiesser K, Domschke W, Kucharzik T. CD4+ T cells transfer resistance against Citrobacter rodentium-induced infectious colitis by induction of Th1 immunity. Scand. J. Immunol. 67: 238-244 (2008). *

• Spazierer D, Skvara H, Dawid M, Fallahi N, Gruber K, Rose K, Lloyd P, Heuerding S, Stingl G, Jung T. T helper 2 biased de novo immune response to keyhole limpet hemocyanin in humans. Clin. Exp. Allergy 39: 999-1008 (2009). *

• Spolski R, Leonard WJ. Cytokine mediators of Th17 function. Eur. J. Immunol. 39: 658-661 (2009). *

• Spriggs MK. Interleukin-17 and its receptor. J. Clin. Immunol. 17: 366-369 (1997).

• Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC. Sphingosine-1-phosphate reduces CD4+ T lymphocyte activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes 57: 484-493 (2008). *

• Stabler T, Piette JC, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 50: 3663-3667 (2004). *

• Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA. Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules. Arthritis Rheum. 58: 1601-1608 (2008). *

• Stamp LK, Easson A, Pettersson L, Highton J, Hessian PA. Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis. J. Rheumatol. 36: 2403-2408 (2009).

• Stamp LK, James MJ, Cleland LG. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol. Cell. Biol. 82: 1-9 (2004). *

• Starnes T, Broxmeyer HE, Robertson MJ, Hromas R. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J. Immunol. 169: 642-646 (2002). *

• Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, Hromas R. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167: 4137-4140 (2001). *

• Staschke KA, Dong S, Saha J, Zhao J, Brooks NA, Hepburn DL, Xia J, Gulen MF, Kang Z, Altuntas CZ, Tuohy VK, Gilmour R, Li X, Na S. IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease. J. Immunol. 183: 568-577 (2009).

• Stebbings SM, Taylor C, Tannock GW, Baird MA, Highton J. The immune response to autologous bacteroides in ankylosing spondylitis is characterized by reduced interleukin 10 production. J. Rheumatol. 36: 797-800 (2009).

• Steinke JW, Borish L. Cytokines and chemokines. J. Allergy Clin. Immunol. 117: S441-S445 (2006).

• Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13: 139-145 (2007). *

• Steinman L. Shifting therapeutic attention in multiple sclerosis to osteopontin, type 1 and type 2 IFN. Eur. J. Immunol. 39: 2358-2360 (2009). *

• Steinman L. Mixed results with modulation of T(H)-17 cells in human autoimmune diseases. Nat. Immunol. 11: 41-44 (2010). *

• Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrucker HW, Stahl RA, Panzer U. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J. Immunol. 183: 4693-4704 (2009).

• Stern JN, Keskin DB, Romero V, Zuniga J, Encinales L, Li C, Awad C, Yunis EJ. Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report. Immunol. Res. 45: 1-12 (2009). *

• Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL. Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc. Natl. Acad. Sci. U.S.A. 105: 5172-5176 (2008). *

• Stetson DB, Medzhitov R. T helper 17 cells get the NOD. Immunity 27: 546-548 (2007). *

• Stock P, Lombardi V, Kohlrautz V, Akbari O. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J. Immunol. 182: 5116-5122 (2009).

• Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 19: 281-286 (2007). *

• Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and adaptive immunity. Semin. Immunol. 19: 353-361 (2007). *

• Stoffels B, Schmidt J, Nakao A, Nazir A, Chanthaphavong RS, Bauer AJ. Role of interleukin 10 in murine postoperative ileus. Gut 58: 648-660 (2009).

• Stojanovic I, Cvjeticanin T, Lazaroski S, Stosic-Grujicic S, Miljkovic D. Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells. Immunology 126: 74-83 (2009). *

• Stolina M, Bolon B, Middleton S, Dwyer D, Brown H, Duryea D, Zhu L, Rohner A, Pretorius J, Kostenuik P, Feige U, Zack D. The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis. J. Clin. Immunol. 29: 158-174 (2009). *

• Stolina M, Schett G, Dwyer D, Vonderfecht S, Middleton S, Duryea D, Pacheco E, Van G, Bolon B, Feige U, Zack D, Kostenuik P. RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNF-alpha or anti-IL-1 therapies. Arthritis Res. Ther. 11: R187 (2009). *

• Stout-Delgado HW, Du W, Shirali AC, Booth CJ, Goldstein DR. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe 6: 446-456 (2009).

• Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 28: 551-558 (2007). *

• Streeck H, Cohen KW, Jolin JS, Brockman MA, Meier A, Power KA, Waring MT, Alter G, Altfeld M. Rapid ex vivo isolation and long-term culture of human Th17 cells. J. Immunol. Methods 333: 115-125 (2008). *

• Stritesky GL, Yeh N, Kaplan MH. IL-23 promotes maintenance but not commitment to the Th17 lineage. J. Immunol. 181: 5948-5955 (2008). *

• Strober W. The role of cytokines in the pathogenesis of experimental and human inflammatory diseases of the mucosal immune system. Falk Symposium 146: GUT-LIVER INTERACTIONS: BASIC AND CLINICAL CONCEPTS, Innsbruck (Austria), March 11-12, 2005, pp. 20-21 (2005). *

• Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 14: 337-342 (2008). *

• Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7: 937-945 (2006). *

• Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8: 1363-1371 (2007). *

• Stummvoll GH, Dipaolo RJ, Huter EN, Davidson TS, Glass D, Ward JM, Shevach EM. Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J. Immunol. 181: 1908-1916 (2008). *

• Sugihara T, Kobori A, Imaeda H, Tsujikawa T, Amagase K, Takeuchi K, Fujiyama Y, Andoh A. The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease. Clin. Exp. Immunol. Jan 19 [Epub ahead of print] (2010). *

• Sugimoto M, Ohno T, Graham DY, Yamaoka Y. Gastric mucosal interleukin-17 and -18 mRNA expression in Helicobacter pylori-induced Mongolian gerbils. Cancer Sci. 100: 2152-2159 (2009). *

• Sugita S, Usui Y, Horie S, Futagami Y, Aburatani H, Okazaki T, Honjo T, Takeuchi M, Mochizuki M. T cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest. Ophthalmol. Vis. Sci. 50: 2862-2870 (2009). *

• Sugiyama M, Arakawa H, Ozawa K, Mizuno T, Mochizuki H, Tokuyama K, Morikawa A. Early-life risk factors for occurrence of atopic dermatitis during the first year. Pediatrics 119: e716-e723 (2007). *

• Sumarac-Dumanovic M, Stevanovic D, Ljubic A, Jorga J, Simic M, Stamenkovic-Pejkovic D, Starcevic V, Trajkovic V, Micic D. Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int. J. Obes. (Lond.) 33: 151-156 (2009). *

• Sun HY, Singh N, Cacciarelli TV, Wannstedt C, Wagener MM, Steele C. Dysregulated expression of T-helper cell responses and susceptibility to infections in high-risk liver transplant recipients. Transpl. Immunol. 20: 68-72 (2008).

• Sun LX, Ren HY, Shi YJ, Wang LH, Qiu ZX. Recombinant human granulocyte colony-stimulating factor significantly decreases the expression of CXCR3 and CCR6 on T cells and preferentially induces T helper cells to a T helper 17 phenotype in peripheral blood harvests. Biol. Blood Marrow Transplant. 15: 835-843 (2009).

• Sun M, Yang P, Du L, Zhou H, Ren X, Kijlstra A. CD4+CD25+ T cells play an important role in the regression phase of experimental autoimmune uveoretinitis. Invest. Ophthalmol. Vis. Sci. Aug 20 [Epub ahead of print] (2009).

• Sun Y, Cai TT, Shen Y, Zhou XB, Chen T, Xu Q. Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorates experimental colitis through regulating cytokine balance. Int. Immunopharmacol. 9: 1437-1443 (2009).

• Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 324: 1334-1338 (2009). *

• Sundrud MS, Rao A. Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just RORgammat anymore. Immunity 28: 5-7 (2008). *

• Sundrud MS, Rao A. New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT. Curr. Opin. Immunol. 19: 287-293 (2007).

• Suryani S, Sutton I. An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis. J. Neuroimmunol. 183: 96-103 (2007).

• Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO. Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur. J. Immunol. 39: 723-729 (2009). *

• Suto A, Kashiwakuma D, Kagami SI, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205: 1369-1379 (2008). *

• Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691 (2006). *

• Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341 (2009). *

• Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Response: characteristics of IL-17-producing gammadelta T cells. Immunity 32: 3-4 (2010). *

• Suzuki S, Kokubu F, Kawaguchi M, Homma T, Odaka M, Watanabe S, Ieki K, Matsukura S, Kurokawa M, Takeuchi H, Sasaki Y, Huang SK, Adachi M, Ota H. Expression of interleukin-17F in a mouse model of allergic asthma. Int. Arch. Allergy Immunol. 143 Suppl. 1: 89-94 (2007).

• Swaidani S, Bulek K, Kang Z, Liu C, Lu Y, Yin W, Aronica M, Li X. The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation. J. Immunol. 182: 1631-1640 (2009).

• Symonds EL, Riedel CU, O'Mahony D, Lapthorne S, O'Mahony L, Shanahan F. Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage. Clin. Exp. Immunol. 157: 148-154 (2009). *

• Szodoray P, Alex P, Frank MB, Turner M, Turner S, Knowlton N, Cadwell C, Dozmorov I, Tang Y, Wilson PC, Jonsson R, Centola M. A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. Rheumatology (Oxford) 45: 1466-1476 (2006). *

• Tada R, Yoshikawa M, Kuge T, Tanioka A, Ishibashi KI, Adachi Y, Tsubaki K, Ohno N. A highly branched 1,3-beta-D-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes. Int. Immunopharmacol. 9: 1431-1436 (2009).

• Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, Yonemura J, Maeda Y, Maruyama N, Kamano T, Kamiya Y, Fujita H, Nakagawa Y, Nagasaka M, Iwata M, Hirata I, Arisawa T. Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa. Int. J. Mol. Med. 24: 563-569 (2009).

• Tajima M, Wakita D, Noguchi D, Chamoto K, Yue Z, Fugo K, Ishigame H, Iwakura Y, Kitamura H, Nishimura T. IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J. Exp. Med. 205: 1019-1027 (2008). *

• Takahashi H, Tsuji H, Hashimoto Y, Ishida-Yamamoto A, Iizuka H. Serum cytokines and growth factor levels in Japanese patients with psoriasis. Clin. Exp. Dermatol. Oct 19 [Epub ahead of print] (2009). *

• Takahashi N, de Jager VC, Gluck A, Letzkus M, Hartmann N, Staedtler F, Ribeiro-Dias F, Heuvelmans-Jacobs M, van den Berg WB, Joosten LA. The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40. Arthritis Rheum. 58: 3471-3484 (2008). *

• Takahashi N, Uehara R, Kobayashi M, Yada Y, Koike Y, Kawamata R, Odaka J, Honma Y, Momoi MY. Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings. Cytokine Dec 24 [Epub ahead of print] (2009).

• Takahashi N, Vanlaere I, de Rycke R, Cauwels A, Joosten LA, Lubberts E, van den Berg WB, Libert C. IL-17 produced by Paneth cells drives TNF-induced shock. J. Exp. Med. 205: 1755-1761 (2008). *

• Takamiya M, Fujita S, Saigusa K, Aoki Y. Simultaneous detections of 27 cytokines during cerebral wound healing by multiplexed bead-based immunoassay for wound age estimation. J. Neurotrauma 24: 1833-1844 (2007).

• Takatori H, Kanno Y, Chen Z, O'Shea JJ. New complexities in helper T cell fate determination and the implications for autoimmune diseases. Mod. Rheumatol. 18: 533-541 (2008). *

• Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206: 35-41 (2009). *

• Takaya H, Andoh A, Makino J, Shimada M, Tasaki K, Araki Y, Bamba S, Hata K, Fujiyama Y, Bamba T. Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in human pancreatic periacinar myofibroblasts. Scand. J. Gastroenterol. 37: 239-245 (2002). *

• Takayanagi H. Osteoclast differentiation and activation. Clin. Calcium 17: 484-492 (2007).

• Takayanagi H. Osteoimmunology and the effects of the immune system on bone. Nat. Rev. Rheumatol. 5: 667-676 (2009).

• Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 135: 552-567.e2 (2008). *

• Takeuchi M, Usui Y, Okunuki Y, Zhang L, Ma J, Yamakawa N, Hattori T, Kezuka T, Sakai JI, Goto H. Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis. Invest. Ophthalmol. Vis. Sci. Jan 20 [Epub ahead of print] (2010).

• Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J. Exp. Med. 206: 2067-2077 (2009). *

• Tallima H, Salah M, Guirguis FR, El Ridi R. Transforming growth factor-beta and Th17 responses in resistance to primary murine Schistosomiasis mansoni. Cytokine 48: 239-245 (2009).

• Tamachi T, Maezawa Y, Ikeda K, Iwamoto I, Nakajima H. Interleukin 25 in allergic airway inflammation. Int. Arch. Allergy Immunol. 140 Suppl. 1: 59-62 (2006).

• Tan AH, Lam KP. Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J. Immunol. Jan 8 [Epub ahead of print] (2010).

• Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C{theta}-deficient mice. J. Immunol. 176: 2872-2879 (2006). *

• Tan W, Huang W, Gu X, Zhong Q, Liu B, Schwarzenberger P. IL-17F/IL-17R interaction stimulates granulopoiesis in mice. Exp. Hematol. 36: 1423-1433 (2008). *

• Tan W, Huang W, Zhong Q, Schwarzenberger P. IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J. Immunol. 176: 6186-6193 (2006). *

• Tan YV, Abad C, Lopez R, Dong H, Liu S, Lee A, Gomariz RP, Leceta J, Waschek JA. Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 106: 2012-2017 (2009). *

• Tanabe S, Hochi S. Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice. Int. J. Mol. Med. 25: 331-336 (2010).

• Tanabe S, Kinuta Y, Saito Y. Bifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammation. Int. J. Mol. Med. 22: 181-185 (2008). *

• Tanaka M, Matsushita T, Tateishi T, Ochi H, Kawano Y, Mei FJ, Minohara M, Murai H, Kira JI. Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. Neurology 71: 974-981 (2008).

• Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura YI, Cua D, Kubo M. Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses. J. Immunol. 183: 7523-7530 (2009). *

• Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS, Su SB, Chan CC, Adorini L, Caspi RR. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J. Immunol. 182: 4624-4632 (2009).

• Tang J, Zhu W, Silver PB, Su SB, Chan CC, Caspi RR. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J. Immunol. 178: 5578-5578 (2007). *

• Tang Y, Desierto MJ, Chen J, Young NS. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure. Blood Nov 10 [Epub ahead of print] (2009). *

• Tanida S, Yoshitomi H, Nishitani K, Ishikawa M, Kitaori T, Ito H, Nakamura T. CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6. Cytokine 47: 112-118 (2009).

• Tarlinton D. IL-17 drives germinal center B cells? Nat. Immunol. 9: 124-126 (2008). *

• Tarner IH, Muller-Ladner U, Gay S. Emerging targets of biologic therapies for rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 3: 336-345 (2007). *

• Tato CM, Laurence A, O'Shea JJ. Helper T cell differentiation enters a new era: le roi est mort; vive le roi! J. Exp. Med. 203: 809-812 (2006). *

• Tawara I, Maeda Y, Sun Y, Lowler KP, Liu C, Toubai T, McKenzie AN, Reddy P. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Exp. Hematol. 36: 988-996 (2008). *

• Taylor BC, Zaph C, Troy AE, Du Y, Guild KJ, Comeau MR, Artis D. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206: 655-667 (2009). *

• Taylor PC. Antibody therapy for rheumatoid arthritis. Curr. Opin. Pharmacol. 3: 323-328 (2003).

• Taylor PC. Anti-cytokines and cytokines in the treatment of rheumatoid arthritis. Curr. Pharm. Des. 9: 1095-1106 (2003).

• Terabe M, Ambrosino E, Takaku S, O'Konek JJ, Venzon D, Lonning S, McPherson JM, Berzofsky JA. Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody. Clin. Cancer Res. 15: 6560-6569 (2009).

• Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, Taniguchi M. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J. Exp. Med. 205: 2727-2733 (2008). *

• Tesar BM, Du W, Shirali AC, Walker WE, Shen H, Goldstein DR. Aging augments IL-17 T-cell alloimmune responses. Am. J. Transplant. 9: 54-63 (2009).

• Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol. Rev. 223: 87-113 (2008). *

• Teunissen MB, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD. Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111: 645-649 (1998). *

• Thacker TC, Palmer MV, Waters WR. T-cell mRNA expression in response to Mycobacterium bovis BCG vaccination and Mycobacterium bovis infection of white-tailed deer. Clin. Vaccine Immunol. 16: 1139-1145 (2009).

• Thakker P, Leach MW, Kuang W, Benoit SE, Leonard JP, Marusic S. IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 178: 2589-2598 (2007). *

• Thebault P, Lhermite N, Tilly G, Le Texier L, Quillard T, Heslan M, Anegon I, Soulillou JP, Brouard S, Charreau B, Cuturi MC, Chiffoleau E. The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J. Immunol. 183: 3099-3108 (2009).

• Thessen Hedreul M, Gillett A, Olsson T, Jagodic M, Harris RA. Characterization of multiple sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. J. Neuroimmunol. 210: 30-39 (2009).

• Thiele K, Riemann D, Navarrete Santos A, Langner J, Kehlen A. Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptor. Eur. Cytokine Netw. 11: 53-58 (2000).

• Thompson JS, Chu Y, Glass JF, Brown SA. Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD. Bone Marrow Transplant. Aug 31 [Epub ahead of print] (2009).

• Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, Vyakarnam A. Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection. PLoS One 5: e9254 (2010). *

• Thorvaldson L, Sandler S. Factors influencing the regulation of cytokine balance during islet transplantation in mice. Transpl. Immunol. 20: 186-194 (2009).

• Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene 19: 2098-2109 (2000). *

• Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. J. Immunol. 183: 5654-5661 (2009).

• Tigno-Aranjuez JT, Lehmann PV, Tary-Lehmann M. Dissociated induction of cytotoxicity and DTH by CFA and CpG. J. Immunother. 32: 389-398 (2009).

• Tilg H, Moschen AR, Kaser A. Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression? Eur. Cytokine Netw. 20: 1-6 (2009).

• Toh HC, Sun L, Soe Y, Wu Y, Phoon YP, Chia WK, Wu J, Wong KY, Tan P. G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. Clin. Immunol. 132: 83-92 (2009). *

• Toh ML, Kawashima M, Zrioual S, Hot A, Miossec P, Miossec P. IL-17 inhibits human Th1 differentiation through IL-12Rbeta2 downregulation. Cytokine 48: 226-230 (2009).

• Toh ML, Miossec P. The role of T cells in rheumatoid arthritis: new subsets and new targets. Curr. Opin. Rheumatol. 19: 284-288 (2007).

• Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur. J. Immunol. 39: 2779-2788 (2009). *

• Tokuda H, Kanno Y, Ishisaki A, Takenaka M, Harada A, Kozawa O. Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. J. Cell. Biochem. 91: 1053-1061 (2004). *

• Tokuda H, Kozawa O, Uematsu T. Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts. Prostaglandins Leukot. Essent. Fatty Acids 66: 427-433 (2002). *

• Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M. MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J. Immunol. 180: 5291-5299 (2008). *

• Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M. Continuous generation of colitogenic CD4+ T cells in persistent colitis. Eur. J. Immunol. 38: 1264-1274 (2008). *

• Tomizawa T, Kaneko Y, Kaneko Y, Saito Y, Ohnishi H, Okajo J, Okuzawa C, Ishikawa-Sekigami T, Murata Y, Okazawa H, Okamoto K, Nojima Y, Matozaki T. Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice. J. Immunol. 179: 869-877 (2007). *

• Tompkins D, Hudgens E, Horohov D, Baldwin CL. Expressed gene sequences of the equine cytokines interleukin-17 and interleukin-23. Vet. Immunol. Immunopathol. 133: 309-313 (2010). *

• Tong H, Miyazaki Y, Yamazaki M, Hara H, Waldmann H, Hori S, Yoshida H. Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice. Immunol. Lett. Jan 8 [Epub ahead of print] (2010).

• Tong T, Zhao W, Wu YQ, Chang Y, Wang QT, Zhang LL, Wei W. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis. Inflamm. Res. Oct 28 [Epub ahead of print] (2009). *

• Toosi S, Bystryn JC. Potential role of interleukin-17 in the pathogenesis of bullous pemphigoid. Med. Hypotheses Nov 27 [Epub ahead of print] (2009).

• Torchinsky MB, Blander JM. T helper 17 cells: discovery, function, and physiological trigger. Cell. Mol. Life Sci. Jan 7 [Epub ahead of print] (2010). *

• Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L. Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. Inflamm. Bowel Dis. 14: 480-490 (2008). *

• Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA. Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol. 8: 825-834 (2007). *

• Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M. Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur. J. Immunol. 38: 1275-1286 (2008). *

• Touil T, Fitzgerald D, Zhang GX, Rostami AM, Gran B. Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis. Drug News Perspect. 19: 77-83 (2006).

• Tournadre A, Porcherot M, Cherin P, Marie I, Hachulla E, Miossec P. Th1 and Th17 balance in inflammatory myopathies: interaction with dendritic cells and possible link with response to high-dose immunoglobulins. Cytokine 46: 297-301 (2009).

• Toy D, Kugler D, Wolfson M, Bos TV, Gurgel J, Derry J, Tocker J, Peschon J. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol. 177: 36-39 (2006). *

• Trajkovic V, Stosic-Grujicic S, Samardzic T, Markovic M, Miljkovic D, Ramic Z, Mostarica Stojkovic M. Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. J. Neuroimmunol. 119: 183-191 (2001).

• Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart AG, Fox DA. Molecular Interactions between T cells and fibroblast-like synoviocytes. Role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am. J. Pathol. 171: 1588-1598 (2007). *

• Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc. Natl. Acad. Sci. U.S.A. 103: 13451-13456 (2006). *

• Traves SL, Donnelly LE. Th17 cells in airway diseases. Curr. Mol. Med. 8: 416-426 (2008).

• Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat. Immunol. 10: 864-871 (2009). *

• Trombone AP, Ferreira Jr SB, Raimundo FM, de Moura KC, Avila-Campos MJ, Silva JS, Campanelli AP, De Franco M, Garlet GP. Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection. J. Periodontal Res. 44: 443-451 (2009).

• Troy AE, Zaph C, Du Y, Taylor BC, Guild KJ, Hunter CA, Saris CJ, Artis D. IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J. Immunol. 183: 2037-2044 (2009).

• Tsuji F, Murai M, Oki K, Seki I, Ueda K, Inoue H, Nagelkerken L, Sasano M, Aono H. Transient receptor potential vanilloid 1 agonists as candidates for anti-inflammatory and immunomodulatory agents. Eur. J. Pharmacol. Oct 27 [Epub ahead of print] (2009).

• Tsuji F, Yoshimi M, Katsuta O, Takai M, Ishihara K, Aono H. Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice. BMC Musculoskelet. Disord. 10: 23 (2009). *

• Tsukimoto M, Nakatsukasa H, Sugawara K, Yamashita K, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates experimental autoimmune encephalomyelitis with up-regulation of regulatory T cells and suppression of IL17 production. Radiat. Res. 170: 429-436 (2008).

• Tsutsui S, Hahn JN, Johnson TA, Ali Z, Jirik FR. Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis. Am. J. Pathol. 173: 1029-1041 (2008). *

• Tsutsui S, Nakamura O, Watanabe T. Lamprey (Lethenteron japonicum) IL-17 upregulated by LPS-stimulation in the skin cells. Immunogenetics 59: 873-882 (2007). *

• Tulic MK, Sly PD, Andrews D, Crook M, Davoine F, Odemuyiwa SO, Charles A, Hodder ML, Prescott SL, Holt PG, Moqbel R. Thymic indoleamine 2,3-dioxygenase positive eosinophils in young children. Potential role in maturation of the naive immune system. Am. J. Pathol. 175: 2043-2052 (2009). *

• Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 58: 2397-2408 (2008). *

• Turner MA, Drury JA, Carlin A, O'Neill S, Pilling D, Barnes N, Balmer P, Newland P, Clark S, Kissack CM, Subhedar NV. CSF cytokine levels in preterm infants may reflect systemic inflammation and are independent of gestation. Early Hum. Dev. 85: 259-262 (2009).

• Turpie B, Yoshimura T, Gulati A, Rios JD, Dartt DA, Masli S. Sjogren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am. J. Pathol. 175: 1136-1147 (2009). *

• Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172: 146-155 (2008). *

• Udagawa N, Kotake S, Kamatani N, Takahashi N, Suda T. The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. Arthritis Res. 4: 281-289 (2002). *

• Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat. Immunol. 9: 769-776 (2008). *

• Uemura Y, Liu TY, Narita Y, Suzuki M, Nakatsuka R, Araki T, Matsumoto M, Iwai LK, Hirosawa N, Matsuoka Y, Murakami M, Kimura T, Hase M, Kohno H, Sasaki Y, Ichihara Y, Ishihara O, Kikuchi H, Sakamoto Y, Jiao SC, Senju S, Sonoda Y. Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells. J. Immunol. 183: 201-208 (2009).

• Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25: 309-318 (2006). *

• Umemura M, Kawabe T, Shudo K, Kidoya H, Fukui M, Asano M, Iwakura Y, Matsuzaki G, Imamura R, Suda T. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol. 16: 1099-1108 (2004). *

• Umemura M, Yahagi A, Hamada S, Begum MD, Watanabe H, Kawakami K, Suda T, Sudo K, Nakae S, Iwakura Y, Matsuzaki G. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J. Immunol. 178: 3786-3796 (2007). *

• Unutmaz D. RORC2: the master of human Th17 cell programming. Eur. J. Immunol. 39: 1452-1455 (2009). *

• Uppal SS, Raghupathy R, Hayat SJ, Longenecker JC, Abraham M, Rawoot P. Disease activity and cytokine production in mitogen-stimulated peripheral blood mononuclear cells from patients with rheumatoid arthritis. Med. Princ. Pract. 19: 33-39 (2010).

• Usui T. Transcription factors that regulate helper T cell differentiation. Nihon Rinsho Meneki Gakkai Kaishi 30: 419-427 (2007). *

• Uyttenhove C, Sommereyns C, Theate I, Michiels T, Van Snick J. Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 1110: 330-336 (2007). *

• Uyttenhove C, Van Snick J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur. J. Immunol. 36: 2868-2874 (2006). *

• Vaknin-Dembinsky A, Balashov K, Weiner HL. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 176: 7768-7774 (2006). *

• Valaperti A, Marty RR, Kania G, Germano D, Mauermann N, Dirnhofer S, Leimenstoll B, Blyszczuk P, Dong C, Mueller C, Hunziker L, Eriksson U. CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J. Immunol. 180: 2686-2695 (2008). *

• Valle-Rios R, Patino-Lopez G, Medina-Contreras O, Canche-Pool E, Recillas-Targa F, Lopez-Bayghen E, Zlotnik A, Ortiz-Navarrete V. Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. Mol. Immunol. 46: 3379-3387 (2009). *

• van Beelen AJ, Teunissen MB, Kapsenberg ML, de Jong EC. Interleukin-17 in inflammatory skin disorders. Curr. Opin. Allergy Clin. Immunol. 7: 374-381 (2007). *

• van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, Muller FJ, Hommes DW, Zaat SA, Kapsenberg ML, de Jong EC. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27: 660-669 (2007). *

• Van bezooijen RL, Farih-Sips HC, Papapoulos SE, Lowik CW. Interleukin-17: a new bone acting cytokine in vitro. J. Bone Miner. Res. 14: 1513-1521 (1999).

• Van Bezooijen RL, Van Der Wee-Pals L, Papapoulos SE, Lowik CW. Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann. Rheum. Dis. 61: 870-876 (2002). *

• Van Bruaene N, Perez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, Schmidt-Weber C, Akdis C, Van Cauwenberge P, Bachert C, Gevaert P. T-cell regulation in chronic paranasal sinus disease. J. Allergy Clin. Immunol. 121: 1435-1441, e1-e3 (2008). *

• van de Veerdonk FL, Kullberg BJ, Verschueren IC, Hendriks T, van der Meer JW, Joosten LA, Netea MG. Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure. Shock Feb 10 [Epub ahead of print] (2010).

• van de Veerdonk FL, Marijnissen R, Joosten LA, Kullberg BJ, Drenth JP, Netea MG, van der Meer JW. Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency. Clin. Exp. Immunol. 159: 57-64 (2010). *

• van de Veerdonk FL, Marijnissen RJ, Kullberg BJ, Koenen HJ, Cheng SC, Joosten I, van den Berg WB, Williams DL, van der Meer JW, Joosten LA, Netea MG. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 5: 329-340 (2009).

• van de Vosse E, van Dissel JT, Ottenhoff TH. Genetic deficiencies of innate immune signalling in human infectious disease. Lancet Infect. Dis. 9: 688-698 (2009).

• Van den Berg WB. Lessons from animal models of arthritis. Curr. Rheumatol. Rep. 4: 232-239 (2002).

• van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat. Rev. Rheumatol. 5: 549-553 (2009).

• van den Berg WB, van Lent PL, Joosten LA, Abdollahi-Roodsaz S, Koenders MI. Amplifying elements of arthritis and joint destruction. Ann. Rheum. Dis. 66 Suppl. 3: iii45-iii48 (2007).

• van der Deen M, Timens W, Timmer-Bosscha H, van der Strate BW, Scheper RJ, Postma DS, de Vries EG, Kerstjens HA. Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice. Respir. Res. 8: 49 (2007). *

• van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182: 5836-5845 (2009).

• van Es T, van Puijvelde GH, Ramos OH, Segers F, Joosten LA, van den Berg WB, Michon IM, de Vos P, van Berkel TJ, Kuiper J. Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem. Biophys. Res. Commun. 388: 261-265 (2009). *

• van Hamburg JP, de Bruijn MJ, de Almeida CR, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38: 2573-2586 (2008). *

• van Hamburg JP, Mus AM, de Bruijn MJ, de Vogel L, Boon L, Cornelissen F, Asmawidjaja P, Hendriks RW, Lubberts E. GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum. 60: 750-759 (2009). *

• van Ingen J, Boeree MJ, Dekhuijzen PR, van Soolingen D. Mycobacterial disease in patients with rheumatic disease. Nat. Clin. Pract. Rheumatol. 4: 649-656 (2008).

• van Leeuwen WM, Lehto M, Karisola P, Lindholm H, Luukkonen R, Sallinen M, Harma M, Porkka-Heiskanen T, Alenius H. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS ONE 4: e4589 (2009). *

• van Lent PL, Grevers LC, Blom AB, Arntz OJ, van de Loo FA, van der Kraan P, Abdollahi-Roodsaz S, Srikrishna G, Freeze H, Sloetjes A, Nacken W, Vogl T, Roth J, van den Berg WB. Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis. Arthritis Rheum. 58: 3776-3787 (2008). *

• van Lieshout AW, van der Voort R, le Blanc LM, Roelofs MF, Schreurs BW, van Riel PL, Adema GJ, Radstake TR. Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, Toll-like receptors and rheumatoid synovial fluid. BMC Immunol. 7: 23 (2006). *

• van Roon JA, Bijlsma JW, Lafeber FP. Diversity of regulatory T cells to control arthritis. Best Pract. Res. Clin. Rheumatol. 20: 897-913 (2006).

• Van YH, Lee WH, Ortiz S, Lee MH, Qin HJ, Liu CP. All-trans retinoic acid inhibits type 1 diabetes by Treg-dependent suppression of IFN-gamma-producing-T-cells without affecting Th17 cells. Diabetes 58: 146-155 (2009). *

• Vanden Eijnden S, Goriely S, De Wit D, Goldman M, Willems F. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. Eur. J. Immunol. 36: 21-26 (2006). *

• Vanden Eijnden S, Goriely S, De Wit D, Willems F, Goldman M. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human. Eur. J. Immunol. 35: 469-475 (2005). *

• Vandooren B, Noordenbos T, Ambarus C, Krausz S, Cantaert T, Yeremenko N, Boumans M, Lutter R, Tak PP, Baeten D. Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis. Arthritis Rheum. 60: 966-975 (2009). *

• Vargas-Inchaustegui DA, Xin L, Soong L. Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J. Immunol. 180: 7537-7545 (2008). *

• Veenbergen S, Bennink MB, de Hooge AS, Arntz OJ, Smeets RL, van den Berg WB, van de Loo FA. Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis. Arthritis Rheum. 58: 3742-3752 (2008). *

• Veenbergen S, Smeets RL, Bennink MB, Arntz OJ, Joosten LA, van den Berg WB, van de Loo FA. The natural soluble form of IL-18 receptor beta exacerbates collagen-induced arthritis via modulation of T cell immune responses. Ann. Rheum. Dis. 69: 276-283 (2010).

• Velasco I, Acien P, Campos A, Acien MI, Ruiz-Macia E. Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression. J. Reprod. Immunol. Jan 12 [Epub ahead of print] (2010).

• Veldhoen M, Hirota K, Christensen J, O'Garra A, Stockinger B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J. Exp. Med. 206: 43-49 (2009). *

• Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B. The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins. Nature 453: 106-109 (2008). *

• Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189 (2006). *

• Veldhoen M, Hocking RJ, Flavell RA, Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7: 1151-1156 (2006). *

• Veldhoen M, Stockinger B. TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. Trends Immunol. 27: 358-361 (2006). *

• Veldhoen M, Stockinger B. Response: characteristics of IL-17-producing gammadelta T cells. Immunity 32: 2 (2010). *

• Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9: 1341-1346 (2008). *

• Velin D, Favre L, Bernasconi E, Bachmann D, Pythoud C, Saiji E, Bouzourene H, Michetti P. Interleukin 17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model. Gastroenterology 136: 2237-2246.e1 (2009). *

• Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B. Resveratrol inhibits high glucose-induced PI3K/AKT/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts. Am. J. Physiol. Heart Circ. Physiol. 294: H2078-H2087 (2008). *

• Veny M, Esteller M, Ricart E, Pique JM, Panes J, Salas A. Late Crohn's disease patients present an increase in peripheral Th17 cells and cytokine production compared with early patients. Aliment. Pharmacol. Ther. 31: 561-572 (2010). *

• Villadsen LS, Schuurman J, Beurskens F, Dam TN, Dagnaes-Hansen F, Skov L, Rygaard J, Voorhorst-Ogink MM, Gerritsen AF, van Dijk MA, Parren PW, Baadsgaard O, van de Winkel JG. Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. J. Clin. Invest. 112: 1571-1580 (2003). *

• Voelz K, Lammas DA, May RC. Cytokine signaling regulates the outcome of intracellular macrophage parasitism by Cryptococcus neoformans. Infect. Immun. 77: 3450-3457 (2009). *

• Vogelgesang A, Rosenberg S, Skrzipek S, Broker BM, Dressel A. Mitoxantrone treatment in multiple sclerosis induces Th2-type cytokines. Acta Neurol. Scand. Nov 19 [Epub ahead of print] (2009).

• Vojdani A, Lambert J. The role of Th17 in neuroimmune disorders: target for CAM therapy. Part II. Evid. Based Complement. Alternat. Med. Jul 21 [Epub ahead of print] (2009). *

• Vojdani A, Lambert J. The role of Th17 in neuroimmune disorders: target for CAM therapy. Part I. Evid. Based Complement. Alternat. Med. Jul 21 [Epub ahead of print] (2009). *

• Vojdani A, Lambert J, Kellermann G. The role of Th17 in neuroimmune disorders: a target for CAM therapy. Part III. Evid. Based Complement. Alternat. Med. Jul 21 [Epub ahead of print] (2009). *

• Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 9: 650-657 (2008). *

• Volpe E, Touzot M, Servant N, Marloie-Provost MA, Hupe P, Barillot E, Soumelis V. Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production. Blood 114: 3610-3614 (2009). *

• von Delwig A, Locke J, Robinson JH, Ng WF. Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum. 62: 143-149 (2009). *

• von Euw E, Chodon T, Attar N, Jalil J, Koya RC, Comin-Anduix B, Ribas A. CTLA4 blockade increases Th17 cells in patients with metastatic melanoma. J. Transl. Med. 7: 35 (2009). *

• von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J. Immunol. 181: 5183-5188 (2008). *

• von Vietinghoff S, Ley K. IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. J. Immunol. 183: 865-873 (2009).

• Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc. Natl. Acad. Sci. U.S.A. 106: 4793-4798 (2009). *

• Vordermeier HM, Villarreal-Ramos B, Cockle PJ, Macaulay M, Rhodes SG, Thacker T, Gilbert SC, McShane H, Hill AV, Xing RZ, Hewinson RG. Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. Infect. Immun. 77: 3364-3373 (2009). *

• Vosters JL, Yin H, Roescher N, Kok MR, Tak PP, Chiorini JA. Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjogren's syndrome. Arthritis Res. Ther. 11: R189 (2009). *

• Waaga-Gasser AM, Grimm MR, Lutz J, Lange V, Lenhard SM, Aviles B, Kist-van Holthe JE, Lebedeva T, Samsonov D, Meyer D, Hancock WW, Heemann U, Gasser M, Chandraker A. Regulatory allospecific T cell clones abrogate chronic allograft rejection. J. Am. Soc. Nephrol. 20: 820-830 (2009).

• Wada Y, Lu R, Zhou D, Chu J, Przewloka T, Zhang S, Li L, Wu Y, Qin J, Balasubramanyam V, Barsoum J, Ono M. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood 109: 1156-1164 (2007). *

• Wagsater D, Lofgren S, Hugander A, Dimberg J. Expression of interleukin-17 in human colorectal cancer. Anticancer Res. 26: 4213-4216 (2006).

• Waibler Z, Kalinke U, Will J, Juan MH, Pfeilschifter JM, Radeke HH. TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol. Immunol. 44: 1483-1489 (2007). *

• Wajant H, Scheurich P. Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling. Int. J. Biochem. Cell Biol. 33: 19-32 (2001). *

• Wakashin H, Hirose K, Maezawa Y, Kagami SI, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H. IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 178: 1023-1032 (2008). *

• Waldburger JM, Firestein GS. Garden of therapeutic delights: new targets in rheumatic diseases. Arthritis Res. Ther. 11: 206 (2009). *

• Walsh KP, Brady MT, Finlay CM, Boon L, Kingston HG. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J. Immunol. 183: 1577-1586 (2009).

• Wang C, Dehghani B, Li Y, Kaler LJ, Vandenbark AA, Offner H. Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1. Immunology 126: 329-335 (2009). *

• Wang DD, Zhao YF, Wang GY, Sun B, Kong QF, Zhao K, Zhang Y, Wang JH, Liu YM, Mu LL, Wang DS, Li HL. IL-17 potentiates neuronal injury induced by oxygen-glucose deprivation and affects neuronal IL-17 receptor expression. J. Neuroimmunol. 212: 17-25 (2009).

• Wang G, Hu P, Yang J, Shen G, Wu X. The effects of PDL-Ig on collagen-induced arthritis. Rheumatol. Int. Dec 25 [Epub ahead of print] (2009). *

• Wang GY, Sun B, Kong QF, Zhang Y, Li R, Wang JH, Wang DD, Lv GX, Li HL. IL-17 eliminates the therapeutic effects of myelin basic protein-induced nasal tolerance in experimental autoimmune encephalomyelitis by activating IL-6. Scand. J. Immunol. 68: 589-597 (2008). *

• Wang J, Ouyang Y, Guner Y, Ford HR, Grishin AV. Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes. J. Immunol. 183: 1384-1392 (2009).

• Wang J, Wang G, Sun B, Li H, Mu L, Wang Q, Li G, Shi L, Jin L, Kostulas N. Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment. J. Autoimmun. 30: 222-229 (2008).

• Wang JX, Tang W, Zhou R, Wan J, Shi LP, Zhang Y, Yang YF, Li Y, Zuo JP. The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses. Br. J. Pharmacol. 153: 1303-1310 (2008). *

• Wang JY, Shyur SD, Wang WH, Liou YH, Lin CG, Wu YJ, Wu LS. The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population. Allergy 64: 1056-1060 (2009). *

• Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J. Exp. Med. 206: 1457-1464 (2009). *

• Wang LF, Chiu HC, Hsu CJ, Liu CY, Hsueh YH, Miaw SC. Epicutaneous sensitization with a protein antigen induces Th17 cells. J. Dermatol. Sci. 54: 192-197 (2009).

• Wang R, Han G, Wang J, Chen G, Xu R, Wang L, Li X, Shen B, Li Y. The pathogenic role of interleukin-27 in autoimmune diabetes. Cell. Mol. Life Sci. 65: 3851-3860 (2008). *

• Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13439-13444 (2009). *

• Wang S, Jiang J, Guan Q, Lan Z, Wang H, Nguan CY, Jevnikar AM, Du C. Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model. Transpl. Immunol. 19: 93-102 (2008).

• Wang SS, Asfaha S, Okumura T, Betz KS, Muthupalani S, Rogers AB, Tu S, Takaishi S, Jin G, Yang X, Wu DC, Fox JG, Wang TC. CFU-F forming bone marrow cells delay progression to gastric dysplasia in a Helicobacter model of gastric tumorigenesis. Stem Cells 27: 2301-2311 (2009).

• Wang T, Martin SA, Secombes CJ. Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated. Dev. Comp. Immunol. Dec 1 [Epub ahead of print] (2009).

• Wang T, Zhao Y, Liu X, Liu X, Li R, Ren LM, Ye H, Li ZG. Possible mechanisms of peripheral elevated CD8+ IL-17+ T cells in rheumatoid arthritis. Zhonghua Yi Xue Za Zhi 89: 1885-1888 (2009).

• Wang W, Edington HD, Rao UN, Jukic DM, Radfar A, Wang H, Kirkwood JM. Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clin. Cancer Res. 14: 8314-8320 (2008). *

• Wang W, Milani M, Ostlie N, Okita D, Agarwal RK, Caspi R, Conti-Fine BM. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J. Immunol. 178: 7072-7080 (2007). *

• Wang WJ, Hao CF, Yi-Lin, Yin GJ, Bao SH, Qiu LH, Lin QD. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J. Reprod. Immunol. Jan 25 [Epub ahead of print] (2010).

• Wang X, Barnes PF, Dobos-Elder KM, Townsend JC, Chung YT, Shams H, Weis SE, Samten B. ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells. J. Immunol. 182: 3668-3677 (2009).

• Wang X, Lin Z, Wei Q, Jiang Y, Gu J. Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis. Rheumatol. Int. 29: 1343-1347 (2009). *

• Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Murata H, Tsutsumi A, Hayashi T, Uchida K, Usui J, Yamagata K, Sumida T. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin. Exp. Immunol. 159: 1-10 (2010). *

• Wang Y, Jia L, Wu CY. Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis. Scand. J. Immunol. 68: 383-390 (2008). *

• Wang Y, Kai H, Chang F, Shibata K, Tahara-Hanaoka S, Honda S, Shibuya A, Shibuya K. A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelytis. Biochem. Biophys. Res. Commun. 353: 857-862 (2007). *

• Wang Y, Mei Y, Feng D, Xu L. Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J. Neurosci. Res. 86: 2441-2449 (2008).

• Wang YH, Liu YJ. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin. Exp. Allergy 39: 798-806 (2009). *

• Wang YH, Liu YJ. The IL-17 cytokine family and their role in allergic inflammation. Curr. Opin. Immunol. 20: 697-702 (2008). *

• Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, Ohba M, Sueki H, Kokubu F, Hizawa N, Adachi M, Huang SK, Iijima M. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J. Invest. Dermatol. 129: 650-656 (2009). *

• Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688 (2006). *

• Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852 (2007). *

• Weaver CT, Murphy KM. T-cell subsets: the more the merrier. Curr. Biol. 17: R61-R63 (2007). *

• Weaver DJ Jr, Reis ES, Pandey MK, Kohl G, Harris N, Gerard C, Kohl J. C5a receptor-deficient dendritic cells promote induction of Treg and Th17. Eur. J. Immunol. Dec 16 [Epub ahead of print] (2009). *

• Webb A, Johnson A, Fortunato M, Platt A, Crabbe T, Christie MI, Watt GF, Ward SG, Jopling LA. Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists. J. Leukoc. Biol. 84: 1202-1212 (2008). *

• Wei B, McPherson M, Turovskaya O, Velazquez P, Fujiwara D, Brewer S, Braun J. Integration of B cells and CD8(+) T in the protective regulation of systemic epithelial inflammation. Clin. Immunol. 127: 303-312 (2008). *

• Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30: 155-167 (2009). *

• Wei L, Laurence A, Elias KM, O'Shea JJ. IL-21 is produced by TH17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282: 34605-34610 (2007). *

• Weiss HA, Millward JM, Owens T. CD8+ T cells in inflammatory demyelinating disease. J. Neuroimmunol. 191: 79-85 (2007).

• Wells JW, Choy K, Lloyd CM, Noble A. Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine. Mucosal Immunol. 2: 54-62 (2009). *

• Wendling D. IL-23 and IL-17 in ankylosing spondylitis. Rheumatol. Int. Nov 4 [Epub ahead of print] (2009). *

• Wendling D, Cedoz JP, Racadot E. Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy. Joint Bone Spine 75: 559-562 (2008). *

• Wendling D, Cedoz JP, Racadot E. Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients. Clin. Rheumatol. 28: 187-190 (2009). *

• Wendling D, Racadot E, Cedoz JP, Dumoulin G. Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 74: 304-305 (2007). *

• Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, Faro-Trindade I, Brown GD, Steele C. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 182: 4938-4946 (2009).

• Wilkie S, Picco G, Foster J, Davies DM, Julien S, Cooper L, Arif S, Mather SJ, Taylor-Papadimitriou J, Burchell JM, Maher J. Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J. Immunol. 180: 4901-4909 (2008). *

• Williams RO, Paleolog E, Feldmann M. Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases. Curr. Opin. Pharmacol. 7: 412-417 (2007).

• Wilson KR, Napper JM, Denvir J, Sollars VE, Yu HD. Defect in early lung defence against Pseudomonas aeruginosa in DBA/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages. Microbiology 153: 968-979 (2007). *

• Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8: 950-957 (2007). *

• Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 180: 720-730 (2009). *

• Winer S, Paltser G, Chan Y, Tsui H, Engleman E, Winer D, Dosch HM. Obesity predisposes to Th17 bias. Eur. J. Immunol. 39: 2629-2635 (2009). *

• Witowski J, Ksiaek K, Jorres A. Interleukin-17: a mediator of inflammatory responses. Cell. Mol. Life Sci. 61: 567-579 (2004). *

• Witowski J, Pawlaczyk K, Breborowicz A, Scheuren A, Kuzlan-Pawlaczyk M, Wisniewska J, Polubinska A, Friess H, Gahl GM, Frei U, Jorres A. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J. Immunol. 165: 5814-5821 (2000). *

• Wolf K, Plano GV, Fields KA. A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signaling via interaction with human Act1. Cell. Microbiol. Jan 21 [Epub ahead of print] (2009). *

• Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, Vom Baur E, Witte K, Warszawska K, Philipp S, Johnson-Leger C, Volk HD, Sterry W, Sabat R. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J. Mol. Med. 87: 523-536 (2009). *

• Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J. Immunol. 178: 5973-5981 (2007). *

• Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol. 39: 3570-3581 (2009). *

• Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22. Semin. Immunopathol. Feb 2 [Epub ahead of print] (2010). *

• Woltman AM, de Haij S, Boonstra JG, Gobin SJ, Daha MR, van Kooten C. Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells. J. Am. Soc. Nephrol. 11: 2044-2055 (2000). *

• Won HY, Min HJ, Ahn JH, Yoo SE, Bae MA, Hong JH, Hwang ES. Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation. Biochem. Pharmacol. Nov 4 [Epub ahead of print] (2009). *

• Wong CK, Cao J, Yin YB, Lam CW. IL-17A activation on bronchial epithelium and basophils: a novel inflammatory mechanism. Eur. Respir. J. Sep 9 [Epub ahead of print] (2009).

• Wong CK, Ho CY, Ko FW, Chan CH, Ho AS, Hui DS, Lam CW. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol. 125: 177-183 (2001). *

• Wong CK, Ho CY, Li EK, Lam CW. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9: 589-593 (2000).

• Wong CK, Lit LC, Tam LS, Li EK, Wong PT, Lam CW. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol. 127: 385-393 (2008). *

• Wong CK, Lun SW, Ko FW, Wong PT, Hu SQ, Chan IH, Hui DS, Lam CW. Activation of peripheral Th17 lymphocytes in patients with asthma. Immunol. Invest. 38: 652-664 (2009). *

• Wong PK, Egan PJ, Croker BA, O'Donnell K, Sims NA, Drake S, Kiu H, McManus EJ, Alexander WS, Roberts AW, Wicks IP. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J. Clin. Invest. 116: 1571-1581 (2006). *

• Wong PK, Quinn JM, Sims NA, van Nieuwenhuijze A, Campbell IK, Wicks IP. Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 54: 158-168 (2006). *

• Wozniak TM, Ryan AA, Britton WJ. Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses. J. Immunol. 177: 8684-8692 (2006). *

• Wozniak TM, Ryan AA, Triccas JA, Britton WJ. Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Infect. Immun. 74: 557-565 (2006). *

• Wraith DC. Anti-cytokine vaccines and the immunotherapy of autoimmune diseases. Eur. J. Immunol. 36: 2844-2848 (2006). *

• Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J. Immunol. 181: 2799-2805 (2008). *

• Wright JF, Guo Y, Quazi A, Luxenberg DP, Bennett F, Ross JF, Qiu Y, Whitters MJ, Tomkinson KN, Dunussi-Joannopoulos K, Carreno BM, Collins M, Wolfman NM. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J. Biol. Chem. 282: 13447-13455 (2007). *

• Wu HY, Center EM, Tsokos GC, Weiner HL. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus 18: 586-596 (2009). *

• Wu HY, Quintana FJ, Weiner HL. Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+CD25-LAP+ regulatory T cell and is associated with down-regulation of IL-17+CD4+ICOS+CXCR5+ follicular helper T cells. J. Immunol. 181: 6038-6050 (2008). *

• Wu Q, Martin RJ, Rino JG, Breed R, Torres RM, Chu HW. IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect. 9: 78-86 (2007). *

• Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med. 15: 1016-1022 (2009). *

• Wu X, Zeng Z, Chen B, Yu J, Xue L, Hao Y, Chen M, Sung JJ, Hu P. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. Int. J. Cancer Nov 10 [Epub ahead of print] (2009). *

• Wust S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Luhder F, Reichardt HM. Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis. PLoS One 4: e8202 (2009). *

• Wuyts WA, Vanaudenaerde BM, Dupont LJ, Van Raemdonck DE, Demedts MG, Verleden GM. Interleukin-17-induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB. J. Heart Lung Transplant. 24: 875-881 (2005).

• Xiao M, Wang C, Zhang J, Li Z, Zhao X, Qin Z. IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res. 69: 2010-2017 (2009). *

• Xiao Y, Motomura S, Podack ER. APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur. J. Immunol. 38: 3450-3458 (2008). *

• Xie D, Hai B, Xie X, Liu L, Ayello J, Ma X, Zhang J. Peripheral CD4(+)CD8(+) cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines. Cell. Immunol. 259: 157-164 (2009). *

• Xie JJ, Wang J, Tang TT, Chen J, Gao XL, Yuan J, Zhou ZH, Liao MY, Yao R, Yu X, Wang D, Cheng Y, Liao YH, Cheng X. The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice Th17/Treg imbalance in atherogenesis. Cytokine Oct 14 [Epub ahead of print] (2009).

• Xie L, Li XK, Funeshima-Fuji N, Kimura H, Matsumoto Y, Isaka Y, Takahara S. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int. Immunopharmacol. 9: 575-581 (2009).

• Xie S, Li J, Wang JH, Wu Q, Yang P, Hsu HC, Smythies LE, Mountz JD. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J. Immunol. Feb 5 [Epub ahead of print] (2010).

• Xin J, Wainwright DA, Serpe CJ, Sanders VM, Jones KJ. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy. Brain Behav. Immun. 22: 528-537 (2008).

• Xiong H, Wei L, Peng B. Immunohistochemical localization of IL-17 in induced rat periapical lesions. J. Endod. 35: 216-220 (2009).

• Xiong W, Zeng D, Xu Y, Fang H, Cao Y, Song Q, Cao C. Expression of interleukin-17 in lung and peripheral blood of asthmatic rats and the influence of dexamethasone. J. Huazhong Univ. Sci. Technolog. Med. Sci. 27: 498-500 (2007).

• Xu D, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR, Pitman N, Kurowska-Stolarska M, McKenzie AN, McInnes IB, Liew FY. IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc. Natl. Acad. Sci. U.S.A. 105: 10913-10918 (2008). *

• Xu G, Xia JH, Zhou H, Yu CZ, Zhang Y, Zuo KJ, Shi JB, Li HB. Interleukin-6 is essential for staphylococcal exotoxin B-induced T regulatory cell insufficiency in nasal polyps. Clin. Exp. Allergy 39: 829-837 (2009).

• Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. Allergy Nov 25 [Epub ahead of print] (2009). *

• Xu J, Wagoner G, Douglas JC, Drew PD. Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity. J. Leukoc. Biol. 86: 401-409 (2009). *

• Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4(+)CD25(-)Foxp3(-) T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178: 6725-6729 (2007). *

• Xu R, Wang R, Han G, Wang J, Chen G, Wang L, Li X, Guo R, Shen B, Li Y. Complement C5a regulates interleukin-17 by affecting the crosstalk between DCs and gammadelta T cells in CLP-induced sepsis. Eur. J. Immunol. Feb 5 [Epub ahead of print] (2010). *

• Xu X, Hsu HC, Chen J, Grizzle WE, Chatham WW, Stockard CR, Wu Q, Yang PA, Holers VM, Mountz JD. Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis. Scand. J. Immunol. 70: 309-16 (2009). *

• Xu Y, DU WJ, Qin LY, Xing ZZ, Qin XH, Chen SJ. Expression of interleukin-17 in hepatitis B related liver fibrosis. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25: 133-135 (2009).

• Xu Y, Hunt NH, Bao S. The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation. Cell Res. 18: 1220-1229 (2008). *

• Yadav M, Rosenbaum J, Goetzl EJ. Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. J. Immunol. 180: 2772-2776 (2008). *

• Yagi Y, Andoh A, Inatomi O, Tsujikawa T, Fujiyama Y. Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts. J. Gastroenterol. 42: 746-753 (2007). *

• Yago T, Nanke Y, Ichikawa N, Kobashigawa T, Mogi M, Kamatani N, Kotake S. IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17. J. Cell. Biochem. 108: 947-955 (2009).

• Yago T, Nanke Y, Kawamoto M, Furuya T, Kobashigawa T, Kamatani N, Kotake S. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 9: R96 (2007). *

• Yamada H. Th17 cells in human rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi 32: 249-255 (2009).

• Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi JI, Kaibara N, Hori A, Iwamoto Y, Yoshikai Y. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 67: 1299-1304 (2008).

• Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H, Kinoshita S. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest. Ophthalmol. Vis. Sci. 50: 2139-2146 (2009). *

• Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol. 179: 7128-7136 (2007). *

• Yamamura T. Interleukin 17-producing T-helper cells and autoimmune diseases: time for a paradigm shift? Curr. Rheumatol. Rep. 9: 93-95 (2007).

• Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S, Nakajima T. Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder. PLoS One 4: e6517 (2009). *

• Yamashita K, Sakai M, Takemoto N, Tsukimoto M, Uchida K, Yajima H, Oshio S, Takeda K, Kojima S. Attenuation of delayed-type hypersensitivity by fullerene treatment. Toxicology 261: 19-24 (2009). *

• Yan LC, Bi EG, Lou YT, Wu XD, Liu ZD, Zhou J, Wang Y, Ma Z, Lin GM, Sun SH, Bian C, Chen AZ, Yao ZJ, Sun B. Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis. Biochem. Biophys. Res. Commun. Dec 14 [Epub ahead of print] (2009). *

• Yang H, Zhang Y, Wu M, Li J, Zhou W, Li G, Li X, Xiao B, Christadoss P. Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3(+) regulatory T-cell profile. Inflamm. Res. Sep 19 [Epub ahead of print] (2009). *

• Yang HX, Zhang W, Zhao LD, Li Y, Zhang FC, Tang FL, He W, Zhang X. Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells? Arthritis Res. Ther. 11: R153 (2009). *

• Yang J, Jia L, Li L, Wu CY. The differentiation and regulation of antigen-specific Th17 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 213-216 (2008).

• Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgammat. Eur. J. Immunol. 38: 1204-1214 (2008). *

• Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J. Autoimmun. 32: 94-103 (2009).

• Yang K, Wen J, Liu X, Kijlstra A, Chen L, Chi W, Zhou H, Huang X, Yang P. Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-gamma in Vogt-Koyanagi-Harada patients. Br. J. Ophthalmol. 93: 249-253 (2009).

• Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454: 350-352 (2008). *

• Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205: 1063-1075 (2008). *

• Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29: 44-56 (2008). *

• Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282: 9358-9363 (2007). *

• Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORalpha and RORgamma. Immunity 28: 29-39 (2008). *

• Yang Y, Weiner J, Liu Y, Smith AJ, Huss DJ, Winger R, Peng H, Cravens PD, Racke MK, Lovett-Racke AE. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 206: 1549-1564 (2009). *

• Yang Z, Sharma AK, Linden J, Kron IL, Laubach VE. CD4(+) T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 137: 695-702 (2009).

• Yang Z, Sharma AK, Marshall M, Kron IL, Laubach VE. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am. J. Respir. Cell. Mol. Biol. 40: 375-381 (2009). *

• Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX, Huang B. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One 5: e8922 (2010). *

• Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM. Malignant B cells skew the balance of regulatory T cells and Th17 cells in B-cell non-Hodgkin's lymphoma. Cancer Res. 69: 5522-5530 (2009).

• Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155: 5483-5486 (1995).

• Yao Z, Spriggs MK, Derry JM, Strockbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ. Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9: 794-800 (1997).

• Yasui T, Uemura H, Yamada M, Matsuzaki T, Tsuchiya N, Noguchi M, Yuzurihara M, Kase Y, Irahara M. Associations of interleukin-6 with interleukin-1beta, interleukin-8 and macrophage inflammatory protein-1beta in midlife women. Cytokine 41: 302-306 (2008).

• Yasukawa S, Dainichi T, Kokuba H, Moroi Y, Urabe K, Hashimoto T, Furue M. Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes. Eur. J. Dermatol. 19: 69-71 (2009).

• Yasumi Y, Takikawa Y, Endo R, Suzuki K. Interleukin-17 as a new marker of severity of acute hepatic injury. Hepatol. Res. 37: 248-254 (2007). *

• Yates MA, Li Y, Chlebeck P, Proctor T, Vandenbark AA, Offner H. Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis. J. Neuroimmunol. Feb 10 [Epub ahead of print] (2010).

• Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR, Schwarzenberger P, Shellito JE, Kolls JK. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am. J. Respir. Cell Mol. Biol. 25: 335-340 (2001). *

• Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194: 519-527 (2001). *

• Yehuda S, Sredni B, Carasso RL, Kenigsbuch-Sredni D. REM sleep deprivation in rats results in inflammation and IL-17 elevation. J. Interferon Cytokine Res. 29: 393-398 (2009).

• Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116: 1310-1316 (2006). *

• Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT, Drake CG. Tc17 CD8 T cells: functional plasticity and subset diversity. J. Immunol. 183: 7161-7168 (2009). *

• Yetkin Ay Z, Sutcu R, Uskun E, Bozkurt FY, Berker E. The impact of the IL-11:IL-17 ratio on the chronic periodontitis pathogenesis: a preliminary report. Oral Dis. 15: 93-99 (2009). *

• Yi A, Jian L, Xiaojing H, Hui X. The prevalence of Th17 cells in patients with dilated cardiomyopathy. Clin. Invest. Med. 32: E144 (2009).

• Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. Blood 114: 3101-3112 (2009). *

• Yi T, Zhao D, Lin CL, Zhang C, Chen Y, Todorov I, Lebon T, Kandeel F, Forman S, Zeng D. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft versus host disease. Blood 112: 2101-2110 (2008). *

• Yin Y, Wen S, Li G, Wang D. Hypoxia enhances stimulating effect of amyloid beta peptide (25-35) for interleukin 17 and T helper lymphocyte subtype 17 upregulation in cultured peripheral blood mononuclear cells. Microbiol. Immunol. 53: 281-286 (2009). *

• Yoo J, Chang HH, Bae YH, Seong CN, Choe NH, Lillehoj HS, Park JH, Min W. Monoclonal antibodies reactive with chicken interleukin-17. Vet. Immunol. Immunopathol. 121: 359-363 (2008). *

• Yoo J, Jang SI, Kim S, Cho JH, Lee HJ, Rhee MH, Lillehoj HS, Min W. Molecular characterization of duck interleukin-17. Vet. Immunol. Immunopathol. 132: 318-322 (2009). *

• Yoon HJ, Lee MS, Ki M, Ihm C, Kim D, Kim Y, Yoo SM. Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? Vector Borne Zoonotic Dis. Jun 1 [Epub ahead of print] (2009).

• Yoon SB, Lee YJ, Park SK, Kim HC, Bae H, Kim HM, Ko SG, Choi HY, Oh MS, Park W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J. Ethnopharmacol. 125: 286-290 (2009).

• Yoshida H, Miyazaki Y, Wang S, Hamano S. Regulation of defense responses against protozoan infection by interleukin-27 and related cytokines. J. Biomed. Biotechnol. 2007: 79401 (2007). *

• Yoshida M, Kanno Y, Ishisaki A, Tokuda H, Hirade K, Nakajima K, Katagiri Y, Shimizu K, Kozawa O. Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. J. Rheumatol. 32: 787-795 (2005).

• Yoshiga Y, Goto D, Segawa S, Ohnishi Y, Matsumoto I, Ito S, Tsutsumi A, Taniguchi M, Sumida T. Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis. Int. J. Mol. Med. 22: 369-374 (2008). *

• Yoshihara K, Yamada H, Hori A, Yajima T, Kubo C, Yoshikai Y. IL-15 exacerbates collagen-induced arthritis with an enhanced CD4(+) T cell response to produce IL-17. Eur. J. Immunol. 37: 2744-2752 (2007). *

• Yoshimura T, Sonoda KH, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, Yoshida H. Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis. Int. Immunol. 20: 209-214 (2008). *

• Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford) 48: 347-354 (2009). *

• Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J. Immunol. 177: 5377-5385 (2006). *

• Young Y, Abreu MT. Advances in the pathogenesis of inflammatory bowel disease. Curr. Gastroenterol. Rep. 8: 470-477 (2006).

• Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, Srivastava M, Linterman M, Zheng L, Simpson N, Ellyard JI, Parish IA, Ma CS, Li QJ, Parish CR, Mackay CR, Vinuesa CG. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31: 457-468 (2009). *

• Yu JJ, Gaffen SL. Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front. Biosci. 13: 170-177 (2008).

• Yu JJ, Ruddy MJ, Conti HR, Boonanantanasarn K, Gaffen SL. The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss. Infect. Immun. 76: 4206-4213 (2008). *

• Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB, Evans RT, Gaffen SL. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 109: 3794-3802 (2007). *

• Yu JP, Sun HY, Li H, Cao S, Xin N, Ren XB. Alloreactive NK cells enhance the effect of donor lymphocyte infusion in the management of relapsed lung cancer after haploidentical hematopoietic stem cell transplantation. Zhongguo Shi Yan Xue Ye Xue Za Zhi 17: 164-169 (2009).

• Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc. Natl. Acad. Sci. U.S.A. 105: 20834-20839 (2008). *

• Yu Y, Iclozan C, Yamazaki T, Yang X, Anasetti C, Dong C, Yu XZ. Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death. Blood 114: 1026-1028 (2009). *

• Yuan J, Cao AL, Yu M, Lin QW, Yu X, Zhang JH, Wang M, Guo HP, Liao YH. Th17 cells facilitate the humoral immune response in patients with acute viral myocarditis. J. Clin. Immunol. Dec 14 [Epub ahead of print] (2009). *

• Yuan J, Yu M, Lin QW, Cao AL, Yu X, Dong JH, Wang JP, Zhang JH, Wang M, Guo HP, Liao YH. Neutralization of IL-17 inhibits the production of anti-ANT autoantibodies in CVB3-induced acute viral myocarditis. Int. Immunopharmacol. Nov 19 [Epub ahead of print] (2009).

• Yuan R, Maeda Y, Li W, Lu W, Cook S, Dowling P. Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE. PLoS ONE 3: e1924 (2008). *

• Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc. Natl. Acad. Sci. U.S.A. 106: 10734-10739 (2009). *

• Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J. Exp. Med. 205: 3133-3144 (2008). *

• Yue C, You X, Zhao L, Wang H, Tang F, Zhang F, Zhang X, He W. The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients. Rheumatol. Int. Oct 22 [Epub ahead of print] (2009). *

• Yue FY, Merchant A, Kovacs CM, Loutfy M, Persad D, Ostrowski MA. Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection. J. Virol. 82: 6767-6771 (2008). *

• Yusuf N, Nasti TH, Katiyar SK, Jacobs MK, Seibert MD, Ginsburg AC, Timares L, Xu H, Elmets CA. Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis. Cancer Res. 68: 3924-3930 (2008). *

• Yusuf N, Nasti TH, Long JA, Naseemuddin M, Lucas AP, Xu H, Elmets CA. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res. 68: 615-622 (2008). *

• Zaba LC, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Farinas MS, Fuentes-Duculan J, Novitskaya I, Khatcherian A, Bluth MJ, Lowes MA, Krueger JG. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J. Exp. Med. 204: 3183-3194 (2007). *

• Zaba LC, Fuentes-Duculan J, Eungdamrong NJ, Abello MV, Novitskaya I, Pierson KC, Gonzalez J, Krueger JG, Lowes MA. Psoriasis Is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J. Invest. Dermatol. 129: 79-88 (2009). *

• Zaba LC, Suarez-Farinas M, Fuentes-Duculan J, Nograles KE, Guttman-Yassky E, Cardinale I, Lowes MA, Krueger JG. Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes. J. Allergy Clin. Immunol. 124: 1022-10.e1-e395 92009). *

• Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, Troy AE, Kobuley DE, Kastelein RA, Cua DJ, Yu Y, Artis D. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J. Exp. Med. 205: 2191-2198 (2008). *

• Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 446: 552-556 (2007). *

• Zarate-Blades CR, Bonato VL, da Silveira EL, E Paula MO, Junta CM, Sandrin-Garcia P, Fachin AL, Mello SS, Cardoso RS, de Sa Galetti FC, Coelho-Castelo AA, Ramos SG, Donadi EA, Sakamoto-Hojo ET, da Silva Passos GA, Silva CL. Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy. J. Gene Med. 11: 66-78 (2009).

• Zdravkovic N, Shahin A, Arsenijevic N, Lukic ML, Mensah-Brown EP. Regulatory T cells and ST2 signaling control diabetes induction with multiple low doses of streptozotocin. Mol. Immunol. 47: 28-36 (2009). *

• Zelante T, Bozza S, De Luca A, D'Angelo C, Bonifazi P, Moretti S, Giovannini G, Bistoni F, Romani L. Th17 cells in the setting of Aspergillus infection and pathology. Med. Mycol. 47 Suppl. 1: S162-S169 (2009). *

• Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 37: 2695-2706 (2007). *

• Zelante T, De Luca A, D'Angelo C, Moretti S, Romani L. IL-17/Th17 in anti-fungal immunity: what's new? Eur. J. Immunol. 39: 645-648 (2009). *

• Zenaro E, Donini M, Dusi S. Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, mannose receptor, and DC-SIGN. J. Leukoc. Biol. 86: 1393-1401 (2009). *

• Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659 (2007). *

• Zhang B, Rong G, Wei H, Zhang M, Bi J, Ma L, Xue X, Wei G, Liu X, Fang G. The prevalence of Th17 cells in patients with gastric cancer. Biochem. Biophys. Res. Commun. 374: 533-537 (2008). *

• Zhang C, Zhang J, Yang B, Wu C. Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine 42: 345-352 (2008).

• Zhang F, Meng G, Strober W. Interactions among the transcription factors Runx1, RORt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 9: 1297-1306 (2008). *

• Zhang GX, Gran B, Yu S, Li J, Siglienti I, Chen X, Kamoun M, Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 170: 2153-2160 (2003). *

• Zhang H, Podojil JR, Luo X, Miller SD. Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J. Immunol. 181: 4638-4647 (2008). *

• Zhang J, Ni J, Chen ZH, Li X, Zhang RJ, Tang W, Zhao WM, Yang YF, Zuo JP. Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells. Acta Pharmacol. Sin. 30: 1144-1152 (2009).

• Zhang J, Pare PD, Sandford AJ. Recent advances in asthma genetics. Respir. Res. 9: 4 (2008). *

• Zhang J, Wang X, Fahmi H, Wojcik S, Fikes J, Yu Y, Wu J, Luo H. Role of TL1A in the pathogenesis of rheumatoid arthritis. J. Immunol. 183: 5350-5357 (2009).

• Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 50: 980-989 (2009).

• Zhang JY, Zhang Z, Lin F, Zou ZS, Xu RN, Jin L, Fu JL, Shi F, Shi M, Wang HF, Wang FS. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 51: 81-91 (2010). *

• Zhang L, Ma J, Takeuchi M, Usui Y, Hattori T, Okunuki Y, Yamakawa N, Kezuka T, Kuroda M, Goto H. Activation of aryl hydrocarbon receptor suppresses experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells. Invest. Ophthalmol. Vis. Sci. Dec 14 [Epub ahead of print] (2009).

• Zhang L, Yang XQ, Cheng J, Hui RS, Gao TW. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin. Immunol. Dec 14 [Epub ahead of print] (2009). *

• Zhang N, Kruger B, Lal G, Luan Y, Yadav A, Zang W, Grimm M, Waaga-Gasser AM, Murphy B, Bromberg JS, Schroppel B. Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival. Immunol. Lett. Oct 28 [Epub ahead of print] (2009).

• Zhang Q, Wu J, Cao Q, Xiao L, Wang L, He D, Ouyang G, Lin J, Shen B, Shi Y, Zhang Y, Li D, Li N. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 60: 3602-3612 (2009). *

• Zhang Q, Yamaza T, Kelly AP, Shi S, Wang S, Brown J, Wang L, French SW, Shi S, Le AD. Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis. PLoS One 4: e7798 (2009). *

• Zhang R, Qian J, Guo J, Yuan YF, Xue K. Suppression of experimental autoimmune uveoretinitis by anti-IL-17 antibody. Curr. Eye Res. 34: 297-303 (2009).

• Zhang W, Luo FJ, Zhou JJ, Zhang WL. Research progress on Th17 cells. Zhejiang Da Xue Xue Bao Yi Xue Ban 36: 620-625 (2007).

• Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol. 183: 1291-1300 (2009).

• Zhang X, Jin J, Peng X, Ramgolam VS, Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J. Immunol. 180: 6988-6996 (2008). *

• Zhang X, Jin J, Tang Y, Speer D, Sujkowska D, Markovic-Plese S. IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. J. Immunol. 182: 3928-3936 (2009).

• Zhang X, Markovic-Plese S. Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. Immunol. Res. 41: 165-174 (2008). *

• Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, Markovic-Plese S. Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. Eur. J. Immunol. 38: 1297-1309 (2008). *

• Zhang Y, Xu G, Zhang L, Roberts AI, Shi Y. Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma. J. Immunol. 181: 190-196 (2008). *

• Zhang YL, Li J, Mo HY, Qiu F, Zheng LM, Qian CN, Zeng YX. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol. Cancer 9: 4 (2010). *

• Zhang Z, Clarke TB, Weiser JN. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J. Clin. Invest. 119: 1899-1909 (2009). *

• Zhang Z, Hinrichs DJ, Lu H, Chen H, Zhong W, Kolls JK. After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease? Int. Immunopharmacol. 7: 409-416 (2007).

• Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J. Immunol. 183: 3160-3169 (2009).

• Zhang Z, Zhang ZY, Fauser U, Schluesener HJ. Valproic acid attenuates inflammation in experimental autoimmune neuritis. Cell. Mol. Life Sci. 65: 4055-4065 (2008). *

• Zhang Z, Zheng M, Bindas J, Schwarzenberger P, Kolls JK. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm. Bowel Dis. 12: 382-388 (2006). *

• Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, Rosenbaum JT. Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice. Cytokine 46: 79-91 (2009).

• Zhang ZY, Zhang Z, Schluesener HJ. FTY720 attenuates lesional interleukin-17+ cell accumulation in rat experimental autoimmune neuritis. Neuropathol. Appl. Neurobiol. 35: 487-495 (2009).

• Zhao C, Yang P, He H, Lin X, Li B, Zhou H, Huang X, Kijlstra A. S-antigen specific T helper type 1 response is present in Behcet's disease. Mol. Vis. 14: 1456-1464 (2008). *

• Zhao J, Li R, He J, Shi J, Long L, Li Z. Mucosal administration of an altered CII263-272 peptide inhibits collagen-induced arthritis by suppression of Th1/Th17 cells and expansion of regulatory T cells. Rheumatol. Int. 29: 9-16 (2008). *

• Zhao XF, Pan HF, Yuan H, Zhang WH, Li XP, Wang GH, Wu GC, Su H, Pan FM, Li WX, Li LH, Chen GP, Ye DQ. Increased serum interleukin 17 in patients with systemic lupus erythematosus. Mol. Biol. Rep. 37: 81-85 (2010). *

• Zhao Y, Balato A, Fishelevich R, Chapoval A, Mann DL, Gaspari AA. Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis. Br. J. Dermatol. 161: 1301-1306 (2009). *

• Zhao Y, Yang J, Gao YD, Guo W. Th17 immunity in patients with allergic asthma. Int. Arch. Allergy Immunol. 151: 297-307 (2009).

• Zheng SG. The critical role of TGF-beta1 in the development of induced Foxp3+ regulatory T cells. Int. J. Clin. Exp. Med. 1: 192-202 (2008). *

• Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 180: 7112-7116 (2008). *

• Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J. Cell Physiol. 222: 95-102 (2010).

• Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotes Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest. Ophthalmol. Vis. Sci. Feb 3 [Epub ahead of print] (2010).

• Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J, Ouyang W. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651 (2007). *

• Zhong W, Xia Z, Hinrichs D, Rosenbaum JT, Wegmann KW, Meyrowitz J, Zhang Z. Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis. J. Pediatr. Gastroenterol. Nutr. 50: 132-139 (2010).

• Zhong Y, Liu Z, Henderson A, Lee K, Hostetter J, Wannemuehler M, Hendrich S. Increased CYP4B1 mRNA is associated with the inhibition of dextran sulfate sodium-induced colitis by caffeic acid in mice. Exp. Biol. Med. (Maywood) 234: 605-616 (2009). *

• Zhou F, He X, Iwakura Y, Horai R, Stuart JM. Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background. Arthritis Rheum. 52: 3731-3738 (2005). *

• Zhou L, Chong MM, Littman DR. Plasticity of CD4(+) T cell lineage differentiation. Immunity 30: 646-655 (2009). *

• Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974 (2007). *

• Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453: 236-240 (2008). *

• Zhou M, Yang B, Ma R, Wu C. Memory Th-17 cells specific for C. albicans are persistent in human peripheral blood. Immunol. Lett. 118: 72-81 (2008).

• Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA. Plasticity of CD4(+) FoxP3(+) T cells. Curr. Opin. Immunol. 21: 281-285 (2009).

• Zhou X, Chen R, Moore J, Kolls JK, Halperin S, Wang J. A critical role of the IL-17/IL-17R axis in regulating host susceptibility to respiratory Chlamydia infection. Infect. Immun. 77: 5059-5070 (2009). *

• Zhou Y, Toh ML, Zrioual S, Miossec P. IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells. Cytokine 38: 157-164 (2007).

• Zhu B, Symonds AL, Martin JE, Kioussis D, Wraith DC, Li S, Wang P. Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupus-like autoimmune disease. J. Exp. Med. 205: 2295-2307 (2008). *

• Zhu J, Davidson TS, Wei G, Jankovic D, Cui K, Schones DE, Guo L, Zhao K, Shevach EM, Paul WE. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J. Exp. Med. 206: 329-341 (2009). *

• Zhu X, Ma D, Zhang J, Peng J, Qu X, Ji C, Hou M. Elevated interleukin-21 correlated to Th17 and Th1 cells in patients with immune thrombocytopenia. J. Clin. Immunol. Dec 10 [Epub ahead of print] (2009). *

• Zimmerman DH, Taylor P, Bendele A, Carambula R, Duzant Y, Lowe V, O'Neill SP, Talor E, Rosenthal KS. CEL-2000: a therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model. Int. Immunopharmacol. Jan 11 [Epub ahead of print] (2010).

• Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chwalinska-Sadowska H, Maslinski W. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol. 164: 2832-2838 (2000). *

• Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J. Immunol. 183: 3522-3530 (2009).

• Zou GM, Tam YK. Cytokines in the generation and maturation of dendritic cells: recent advances. Eur. Cytokine Netw. 13: 186-199 (2002).

• Zozulya AL, Ortler S, Lee J, Weidenfeller C, Sandor M, Wiendl H, Fabry Z. Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS. J. Neurosci. 29: 140-152 (2009).

• Zrioual S, Toh ML, Tournadre A, Zhou Y, Cazalis MA, Pachot A, Miossec V, Miossec P. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J. Immunol. 180: 655-663 (2008). *

• Zuber J, Brodin-Sartorius A, Lapidus N, Patey N, Tosolini M, Candon S, Rabant M, Snanoudj R, Panterne C, Thervet E, Legendre C, Chatenoud L. FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis. Nephrol. Dial. Transplant. 24: 3847-3854 (2009).

• Zygmunt BM, Rharbaoui F, Groebe L, Guzman CA. Intranasal immunization promotes Th17 immune responses. J. Immunol. 183: 6933-6938 (2009).

Number of references = 2224

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