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Scientific Literature, CAR
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Aarnisalo P, Kim CH, Lee JW, Perlmann T 2002 Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.
J. Biol. Chem. 277: 35118-35123.
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Akanuma SI, Hori S, Ohtsuki S, Fujiyoshi M, Terasaki T 2008 Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier.
Neurochem. Int. 52: 669-674.
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Al-Dosari MS, Knapp JE, Liu D 2006 Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver.
Mol. Pharm. 3: 322-328.
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Alnouti Y, Klaassen CD 2008 Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice.
J. Pharmacol. Exp. Ther. 324: 612-621.
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Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G 2007 Alterations in xenobiotic metabolism in the long-lived Little mice.
Aging Cell 6: 453-470.
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Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW 2007 Gender dictates the nuclear receptor mediated regulation of CYP3A44.
Drug Metab. Dispos. 35: 36-42.
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Arnold KA, Eichelbaum M, Burk O 2004 Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor.
Nucl. Recept. 2: 1.
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Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD 2004 Interactions between hepatic Mrp4 and Sult2A as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
J. Biol. Chem. 279: 22250-22257.
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Assenat E, Gerbal-Chaloin S, Larrey D, Saric J, Fabre JM, Maurel P, Vilarem MJ, Pascussi JM 2004 Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.
Hepatology 40: 951-960.
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Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ 2007 CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.
Drug Metab. Dispos. 35: 428-439.
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Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ 2003 Alternatively spliced isoforms of the human constitutive androstane receptor.
Nucleic Acids Res. 31: 3194-3207.
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Auerbach SS, Stoner MA, Su S, Omiecinski CJ 2005 Retinoid X receptor-dependent transactivation by a naturally occurring structural variant of human CAR (NR1I3).
Mol. Pharmacol. 68: 1239-1253.
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Bae Y, Kemper JK, Kemper B 2004 Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
DNA Cell Biol. 23: 81-91.
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Bainy AC 2007 Nuclear receptors and susceptibility to chemical exposure in aquatic organisms.
Environ. Int. 33: 571-575.
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Baskin-Bey ES, Anan A, Isomoto H, Bronk SF, Gores GJ 2007 Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.
World J. Gastroenterol. 13: 5635-5641.
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Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ 2006 Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
Hepatology 44: 252-262.
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Beaudet MJ, Desrochers M, Lachaud AA, Anderson A 2005 The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta, and the liver X receptor.
Biochem. J. 388: 407-418.
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Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR 2002 Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.
Biochem. Biophys. Res. Commun. 293: 145-149.
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Bell AW, Michalopoulos GK 2006 Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.
Hepatology 44: 186-194.
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Blattler SM, Rencurel F, Kaufmann MR, Meyer UA 2007 In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.
Proc. Natl. Acad. Sci. U.S.A. 104: 1045-1050.
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Bock KW, Kohle C 2005 UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects.
Methods Enzymol. 400: 57-75.
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Boyer JL 2005 Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?
Gastroenterology 129: 735-740.
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Burk O, Arnold KA, Geick A, Tegude H, Eichelbaum M 2005 A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.
Biol. Chem. 386: 503-513.
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Burk O, Arnold KA, Nussler AK, Schaeffeler E, Efimova E, Avery BA, Avery MA, Fromm MF, Eichelbaum M 2005 Anti-malarial artemisinin drugs induce CYP and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.
Mol. Pharmacol. 67: 1954-1965.
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Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmoller J, Zanger UM, Wojnowski L 2004 The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).
J. Biol. Chem. 279: 38379-38385.
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Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ 2002 The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
Eur. J. Pharm. Sci. 15: 89-96.
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Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P 2007 Valproic acid induces CYP3A4 and MDR1 genes expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Drug Metab. Dispos. 35: 1032-1041.
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Chandra P, Brouwer KL 2004 The complexities of hepatic drug transport: current knowledge and emerging concepts.
Pharm. Res. 21: 719-735.
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Chang TK, Bandiera SM, Chen J 2003 Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels.
Drug Metab. Dispos. 31: 7-10.
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Chang TK, Waxman DJ 2006 Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).
Drug Metab. Rev. 38: 51-73.
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Chatterjee B, Echchgadda I, Song CS 2005 Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1.
Methods Enzymol. 400: 165-191.
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Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Tseng HC, Jeng YM, Chang MH 2008 Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.
Pediatr. Res. 63: 667-673.
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Chen J, Raymond K 2006 Treatment effect of rifampicin on cholestasis.
The Internet Journal of Pharmacology Vol. 4 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol4n2/colestasis.xml).
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Chen X, Zhang J, Baker SM, Chen G 2007 Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).
Toxicology 231: 224-233.
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Chen Y, Ferguson SS, Negishi M, Goldstein JA 2004 Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.
J. Pharmacol. Exp. Ther. 308: 495-501.
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Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD 2003 Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
Drug Metab. Dispos. 31: 1315-1319.
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Chiang JY 2005 Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Curr. Opin. Investig. Drugs 6: 994-1001.
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Cui X, Thomas A, Montgomery D, Gu C, Morrison RA, White RE, Cheng KC 2005 Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices.
Comb. Chem. High Throughput Screen. 8: 341-346.
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Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ 2005 RXRalpha regulates the expression of glutathione S-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver.
Mol. Pharmacol. 68: 1590-1596.
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Dai G, Wan YJ 2005 Animal models of xenobiotic receptors.
Curr. Drug Metab. 6: 341-355.
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Daly AK 2006 Significance of the minor cytochrome P450 3A isoforms.
Clin. Pharmacokinet. 45: 13-31.
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Dickins M 2004 Induction of cytochromes P450.
Curr. Top. Med. Chem. 4: 1745-1766.
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Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL 2006 Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
J. Biol. Chem. 281: 26540-26551.
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Ding X, Staudinger JL 2005 The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter.
J. Pharmacol. Exp. Ther. 314: 120-127.
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Dixit SG, Tirona RG, Kim RB 2005 Beyond CAR and PXR.
Curr. Drug Metab. 6: 385-397.
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Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S 2006 Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Mol. Pharmacol. 70: 329-339.
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Dvorak Z, Maurel P, Vilarem MJ, Ulrichova J, Modriansky M 2007 Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.
Cell Biol. Toxicol. 23: 63-73.
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Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichova J, Maurel P, Pascussi JM 2003 Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.
Mol. Pharmacol. 64: 160-169.
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Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B 2007 The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.
Mol. Endocrinol. 21: 2099-2111.
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El-Sankary W, Bombail V, Gibson GG, Plant N 2002 Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
Drug Metab. Dispos. 30: 1029-1034.
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Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H 2006 Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
J. Pharmacol. Exp. Ther. 317: 1200-1209.
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Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski C, Lecluyse E, Negishi M, Wang H 2007 Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
J. Pharmacol. Exp. Ther. 320: 72-80.
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Ferguson SS, Chen Y, Lecluyse EL, Negishi M, Goldstein JA 2005 Human CYP2C8 is transcriptionally regulated by the nuclear receptors CAR, PXR, GR, and HNF4alpha.
Mol. Pharmacol. 68: 747-757.
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Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA 2002 Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
Mol. Pharmacol. 62: 737-746.
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Finkelstein D, Lamba V, Assem M, Rengelshausen J, Yasuda K, Strom S, Schuetz E 2006 ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics.
Xenobiotica 36: 989-1012.
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Fiorucci S, Rizzo G, Donini A, Distrutti E, Santucci L 2007 Targeting farnesoid X receptor for liver and metabolic disorders.
Trends Mol. Med. 13: 298-309.
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Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ 2007 Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of CAR and NRF2.
Drug Metab. Dispos. 35: 995-1000.
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Fisher CD, Jackson JP, Lickteig AJ, Augustine LM, Cherrington NJ 2008 Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
Arch. Toxicol. May 17 [Epub ahead of print].
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Forman BM, Tzameli I, Choi HS, Chen J, Simha D, Seol W, Evans RM, Moore DD 1998 Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta.
Nature 395: 612-615.
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Frank C, Gonzalez MM, Oinonen C, Dunlop TW, Carlberg C 2003 Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor.
J. Biol. Chem. 278: 43299-43310.
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Fuhr U 2000 Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans.
Clin. Pharmacokinet. 38: 493-504.
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Gachon F, Olela FF, Schaad O, Descombes P, Schibler U 2006 The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.
Cell Metab. 4: 25-36.
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Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C 2003 Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Hepatology 38: 345-354.
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Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W 2002 Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.
Xenobiotica 32: 165-206.
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Gillberg M, Skaanild MT, Friis C 2006 Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR.
Basic Clin. Pharmacol. Toxicol. 98: 480-487.
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Gong H, Xie W 2004 Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential.
Expert Opin. Ther. Targets 8: 49-54.
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Gonzalez MM, Carlberg C 2002 Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
J. Biol. Chem. 277: 18501-18509.
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Goodwin B, Hodgson E, D'Costa DJ, Robertson GR, Liddle C 2002 Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor.
Mol. Pharmacol. 62: 359-365.
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Goodwin B, Moore JT 2004 CAR: detailing new models.
Trends Pharmacol. Sci. 25: 437-441.
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Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA 2001 Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
Mol. Pharmacol. 60: 427-431.
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Greger DL, Blum JW 2007 Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves.
J. Anim. Physiol. Anim. Nutr. (Berl.) 91: 62-67.
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Greger DL, Gropp F, Morel C, Sauter S, Blum JW 2006 Nuclear receptor and target gene mRNA abundance in duodenum and colon of dogs with chronic enteropathies.
Domest. Anim. Endocrinol. 31: 327-329.
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Greger DL, Philipona C, Blum JW 2006 Ontogeny of mRNA abundance of nuclear receptors and nuclear receptor target genes in young cattle.
Domest. Anim. Endocrinol. 31: 76-87.
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Gropp FN, Greger DL, Morel C, Sauter S, Blum JW 2006 Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs.
J. Anim. Sci. 84: 2684-2691.
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Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C 2007 The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
Chem. Biol. Interact. 168: 66-73.
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Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, Reddy JK 2006 Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Biochem. Biophys. Res. Commun. 347: 485-495.
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Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK 2007 Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
J. Biol. Chem. 282: 36766-36776.
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Guo GL, Choudhuri S, Klaassen CD 2002 Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
J. Pharmacol. Exp. Ther. 300: 206-212.
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Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ 2003 Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
J. Biol. Chem. 278: 45062-45071.
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Handschin C, Blaettler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA 2004 The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.
Nucl. Recept. 2: 7.
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Handschin C, Meyer UA 2005 Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.
Arch. Biochem. Biophys. 433: 387-396.
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Handschin C, Meyer UA 2003 Induction of drug metabolism: the role of nuclear receptors.
Pharmacol. Rev. 55: 649-673.
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Handschin C, Podvinec M, Amherd R, Looser R, Ourlin JC, Meyer UA 2002 Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.
J. Biol. Chem. 277: 29561-29567.
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Handschin C, Podvinec M, Looser R, Amherd R, Meyer UA 2001 Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor.
Mol. Pharmacol. 60: 681-689.
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Handschin C, Podvinec M, Meyer UA 2000 CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Proc. Natl. Acad. Sci. U.S.A. 97: 10769-10774.
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Handschin C, Podvinec M, Stockli J, Hoffmann K, Meyer UA 2001 Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
Mol. Endocrinol. 15: 1571-1585.
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Hariparsad N, Carr BA, Evers R, Chu X 2008 Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction.
Drug Metab. Dispos. 36: 1046-1055.
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Harmsen S, Meijerman I, Beijnen JH, Schellens JH 2007 The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology.
Cancer Treat. Rev. 33: 369-380.
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Hartley DP, Dai X, He YD, Carlini EJ, Wang B, Huskey SE, Ulrich RG, Rushmore TH, Evers R, Evans DC 2004 Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression.
Mol. Pharmacol. 65: 1159-1171.
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Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB 2008 A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
Drug Metab. Dispos. 36: 500-507.
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Hernandez JP, Chapman LM, Kretschmer XC, Baldwin WS 2006 Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice.
Toxicol. Appl. Pharmacol. 216: 186-196.
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Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS 2007 The environmental estrogen, nonylphenol, activates the constitutive androstane receptor (CAR).
Toxicol. Sci. 98: 416-426.
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Honkakoski P, Sueyoshi T, Negishi M 2003 Drug-activated nuclear receptors CAR and PXR.
Ann. Med. 35: 172-182.
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Hosseinpour F, Moore R, Negishi M, Sueyoshi T 2006 Serine-202 regulates the nuclear translocation of constitutive active/androstane receptor CAR.
Mol. Pharmacol. 69: 1095-1102.
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Hu R, Wu W, Niles EG, Loverde PT 2006 Isolation and characterization of Schistosoma mansoni constitutive androstane receptor.
Mol. Biochem. Parasitol. 148: 31-43.
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Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, Moore DD 2003 Induction of bilirubin clearance by the constitutive androstane receptor (CAR).
Proc. Natl. Acad. Sci. U.S.A. 100: 4156-4161.
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Huang W, Zhang J, Moore DD 2004 A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.
J. Clin. Invest. 113: 137-143.
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Inoue K, Borchers CH, Negishi M 2006 Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics.
Biochem. J. 398: 125-133.
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Itoh M, Nakajima M, Higashi E, Yoshida R, Nagata K, Yamazoe Y, Yokoi T 2006 Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
J. Pharmacol. Exp. Ther. 319: 693-702.
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Jackson JP, Ferguson SS, Negishi M, Goldstein JA 2006 Phenytoin induction of the Cyp2c37 gene is mediated by the constitutive androstane receptor.
Drug Metab. Dispos. 34: 2003-2010.
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Jacobs MN, Lewis DF 2002 Steroid hormone receptors and dietary ligands: a selected review.
Proc. Nutr. Soc. 61: 105-122.
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Jia Y, Guo GL, Surapureddi S, Sarkar J, Qi C, Guo D, Xia J, Kashireddi P, Yu S, Cho YW, Rao MS, Kemper B, Ge K, Gonzalez FJ, Reddy JK 2005 Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.
Proc. Natl. Acad. Sci. U.S.A. 102: 12531-12536.
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Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O 2006 Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
Drug Metab. Dispos. 34: 1756-1763.
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Jyrkkarinne J, Makinen J, Gynther J, Savolainen H, Poso A, Honkakoski P 2003 Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.
J. Med. Chem. 46: 4687-4695.
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Jyrkkarinne J, Windshugel B, Makinen J, Ylisirnio M, Perakyla M, Poso A, Sippl W, Honkakoski P 2005 Amino acids important for ligand specificity of the human constitutive androstane receptor.
J. Biol. Chem. 280: 5960-5971.
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Kakizaki S, Yamazaki Y, Kosone T, Horigichi N, Sohara N, Sato K, Takagi H, Yoshinari K, Mori M 2007 Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor.
Liver Int. 27: 109-119.
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Karlsen TH, Boberg KM, Schrumpf E 2006 Role of polymorphisms in genes involved in bile acid detoxification pathways in primary sclerosing cholangitis.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 87. *
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Kassam A, Winrow CJ, Fernandez-Rachubinski F, Capone JP, Rachubinski RA 2000 The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated …
J. Biol. Chem. 275: 4345-4350.
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Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA 2002 Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
J. Biol. Chem. 277: 2908-2915.
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Kawase A, Tsunokuni Y, Iwaki M 2007 Effects of alterations in CAR on bilirubin detoxification in mouse collagen-induced arthritis.
Drug Metab. Dispos. 35: 256-261.
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Kawase A, Yoshida I, Tsunokuni Y, Iwaki M 2007 Decreased PXR and CAR inhibit transporter and CYP mRNA levels in the liver and intestine of mice with collagen-induced arthritis.
Xenobiotica 37: 366-374.
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Kim J, Min G, Kemper B 2001 Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation …
J. Biol. Chem. 276: 7559-7567.
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Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C 2003 Repression of farnesoid X receptor during the acute phase response.
J. Biol. Chem. 278: 8988-8995.
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Kim MS, Shigenaga J, Moser A, Grunfeld C, Feingold KR 2004 Suppression of DHEA sulfotransferase (Sult2A1) during the acute phase response.
Am. J. Physiol. Endocrinol. Metab. 287: E731-E738.
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Kleiner HE, Xia X, Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, Digiovanni J 2008 Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.
Toxicol. Appl. Pharmacol. Jul 15 [Epub ahead of print].
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David and Judy Rhodes
Last Update: 9/25/2008
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