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Scientific Literature, BSEP
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Acalovschi M, Tirziu S, Chiorean E, Krawczyk M, Grunhage F, Lammert F. Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls.
Lipids 44: 521-526 (2009).
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Akashi M, Tanaka A, Takikawa H. Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats.
Hepatol. Res. 34: 193-198 (2006).
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Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.
Biochim. Biophys. Acta 1511: 7-16 (2001).
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Albrecht C, Elliott JI, Sardini A, Litman T, Stieger B, Meier PJ, Higgins CF. Functional analysis of candidate ABC transporter proteins for sitosterol transport.
Biochim. Biophys. Acta 1567: 133-142 (2002).
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Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications.
Pharm. Res. 24: 1803-1823 (2007).
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Alvarez L, Jara P, Sanchez-Sabate E, Hierro L, Larrauri J, Diaz MC, Camarena C, De La Vega A, Frauca E, Lopez-Collazo E, Lapunzina P. Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1.
Hum. Mol. Genet. 13: 2451-2460 (2004).
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Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.
J. Biol. Chem. 276: 28857-28865 (2001).
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Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy FJ, Walsh MJ. Ligand-dependent activation of the farnesoid-X-receptor directs arginine methylation of histone H3 by CARM1.
J. Biol. Chem. 279: 54348-54357 (2004).
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Aoki K, Saso N, Kato S, Sugiyama Y, Sato H. Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
Biol. Pharm. Bull. 31: 1882-1887 (2008).
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Arab JP, Ramirez C, Munoz P, Pizarro M, Solís N, Riquelme A, Arrese M. Effects of Japanese herbal medicine inchin-ko-to on endotoxin-induced cholestasis in the rat.
Ann. Hepatol. 8: 228-233 (2009).
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Arrese M. Cholestasis during pregnancy: rare hepatic diseases unmasked by pregnancy.
Ann. Hepatol. 5: 216-218 (2006).
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Arrese M, Ananthanarayanan M. The bile salt export pump: molecular properties, function and regulation.
Pflugers Arch. 449: 123-131 (2004).
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Asamoto Y, Tazuma S, Ochi H, Chayama K, Suzuki H. Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function.
Biochem. J. 359: 605-610 (2001).
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Balistreri WF. Genetic liver disease.
54th Annual Meeting of the American Association for the Study of Liver Diseases (2003).
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Ballatori N, Henson JH, Seward DJ, Cai SY, Runnegar M, Fricker G, Miller DS, Boyer JL. Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis.
Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 144: 167-179 (2006).
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Ballatori N, Rebbeor JF, Connolly GC, Seward DJ, Lenth BE, Henson JH, Sundaram P, Boyer JL. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump.
Am. J. Physiol. Gastrointest. Liver Physiol. 278: G57-G63 (2000).
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Beilke LD, Besselsen DG, Cheng Q, Kulkarni S, Slitt AL, Cherrington NJ. Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Toxicol. Sci. 102: 196-204 (2008).
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Bergasa NV, Mason A, Floreani A, Heathcote J, Swain MG, Jones DE, Lindor KM, Bassendine MF, Worman HJ. Primary biliary cirrhosis: report of a focus study group.
Hepatology 40: 1013-1020 (2004).
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Beuers U. Mechanisms of action of ursodeoxycholic acid for treatment of primary sclerosing cholangitis.
Falk Workshop "Primary Sclerosing Cholangitis: Complications and Consequences", Moscow (Russia), June 11, 2006, p. 12 (2006). *
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Beuers U. Mechanisms of action of ursodeoxycholic acid in cholestasis.
Falk Symposium 136. XII FALK LIVER WEEK 2003 (Part I) In Honour of Hans Popper’s 100th Birthday. Cholestatic Liver Diseases: Therapeutical Options and Perspectives. Freiburg (Germany). p. 49-50. October 15-16 (2003). *
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Beuers U, Hohenester S, Wimmer R, Denk GU, Rust C. Mitogen activated protein kinases and protein kinase C: short-term mediators of the anticholestatic effect of tauroursodeoxycholic acid in bile acid-induced cholestasis?
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 61. June 18-19 (2004). *
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Bi YA, Kazolias DC, Duignan DB. Use of cryopreserved human hepatocytes in sandwich-culture to measure hepatobiliary transport.
Drug Metab. Dispos. 34: 1658-1665 (2006).
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Bock HH, Lammert F. Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense.
Hepatology 35: 232-234 (2002).
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Bode KA, Donner MG, Leier I, Keppler D. Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.
Biochem. Pharmacol. 64: 151-158 (2002).
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Bohan A, Chen WS, Denson LA, Held MA, Boyer JL. Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis.
J. Biol. Chem. 278: 36688-36698 (2003).
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Bohme M, Jedlitschky G, Leier I, Buchler M, Keppler D. ATP-dependent export pumps and their inhibition by cyclosporins.
Adv. Enzyme Regul. 34: 371-380 (1994).
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Bohme M, Muller M, Leier I, Jedlitschky G, Keppler D. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.
Gastroenterology 107: 255-265 (1994).
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Bolder U, Jeschke MG, Landmann L, Wolf F, de Sousa C, Schlitt HJ, Przkora R. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms.
Cell Stress Chaperones 11: 89-100 (2006).
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Bolder U, Schmidt A, Landmann L, Kidder V, Tange S, Jauch KW. Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism.
Gastroenterology 122: 963-973 (2002).
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Boyer JL. Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?
Gastroenterology 129: 735-740 (2005).
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Boyer JL, Denk G, Bohan A, Chen WS, Soroka C, Denson L. Adaptive regulation of bile salt transporters in cholestasis.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 46-47. June 18-19 (2004). *
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Byrne JA, Strautnieks SS, Ihrke G, Knisely AS, Jirsa M, Cebecauerova D, Linton KJ, Higgins CF, Mieli-Vergani G, Thompson RJ. Investigation of the disease mechanisms associated with missense mutations in the bile salt export pump, BSEP.
Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 61 (2006). *
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Byrne JA, Strautnieks SS, Ihrke G, Pagani F, Knisely AS, Linton KJ, Mieli-Vergani G, Thompson RJ. Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing.
Hepatology 49: 553-567 (2009).
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Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ. The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.
Gastroenterology 123: 1649-1658 (2002).
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Cai SY, Boyer JL. FXR: a target for cholestatic syndromes?
Expert Opin. Ther. Targets 10: 409-421 (2006).
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Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.
Gastroenterology 136: 1060-1069.e4 (2009).
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Cai SY, Wang L, Ballatori N, Boyer JL. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.
Am. J. Physiol. Gastrointest. Liver Physiol. 281: G316-G322 (2001).
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Cantz T, Nies AT, Brom M, Hofmann AF, Keppler D. MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 278: G522-G531 (2000).
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Carlton VE, Pawlikowska L, Bull LN. Molecular basis of intrahepatic cholestasis.
Ann. Med. 36: 606-617 (2004).
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Carter BA, Prendergast DR, Taylor OA, Zimmerman TL, Furstenberg RV, Moore DD, Karpen SJ. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR.
Pediatr. Res. 62: 301-306 (2007).
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Cassio D, Macias RI, Grosse B, Marin JJ, Monte MJ. Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10.
Cell Tissue Res. 330: 447-460 (2007).
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Cavestro GM, Frulloni L, Cerati E, Ribeiro LA, Corrente V, Sianesi M, Franze A, Di Mario F. Progressive familial intrahepatic cholestasis.
Acta Biomed. Ateneo. Parmense. 73: 53-56 (2002).
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Chandra P, Brouwer KL. The complexities of hepatic drug transport: current knowledge and emerging concepts.
Pharm. Res. 21: 719-735 (2004).
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Chen BC, Kuo KK, Chen YH, Liu CH, Tsai LY, Hsu HK, Hsu C. Retinoid X receptor alpha participation in dexamethasone induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
Shock 32: 164-171 (2009).
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Chen F, Ellis E, Strom SC, Shneider BL. ATPase class I type 8B member 1 and protein kinase C-zeta induce the expression of the canalicular bile salt export pump in human hepatocytes.
Pediatr. Res. Oct 5 [Epub ahead of print] (2009).
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Chen G, Wang S, Bie P, Li X, Dong J. Endogenous bile salts are associated with bile duct injury in the rat liver transplantation model.
Transplantation 87: 330-339 (2009).
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Chen HL, Chen HL, Liu YJ, Feng CH, Wu CY, Shyu MK, Yuan RH, Chang MH. Developmental expression of canalicular transporter genes in human liver.
J. Hepatol. 43: 472-477 (2005).
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Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Tseng HC, Jeng YM, Chang MH. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.
Pediatr. Res. 63: 667-673 (2008).
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Chen HL, Liu YJ, Su YN, Wang NY, Wu SH, Ni YH, Hsu HY, Wu TC, Chang MH. Diagnosis of BSEP/ABCB11 mutations in Asian patients with cholestasis using denaturing high performance liquid chromatography.
J. Pediatr. 153: 825-832.e2 (2008).
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Chen HL, Wang R, Chen HL, Hwu WL, Jeng YM, Chang MH, Ling V. Bone marrow transplantation results in donor-derived hepatocytes in an animal model of inherited cholestatic liver disease.
J. Biomed. Sci. 15: 615-622 (2008).
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Chen J, Raymond K. Treatment effect of rifampicin on cholestasis.
The Internet Journal of Pharmacology Vol. 4 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol4n2/colestasis.xml) (2006). *
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Chen ST, Chen HL, Su YN, Liu YJ, Ni YH, Hsu HY, Chu CS, Wang NY, Chang MH. Prenatal diagnosis of progressive familial intrahepatic cholestasis type 2.
J. Gastroenterol. Hepatol. 23: 1390-1393 (2008).
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Cheng X, Buckley D, Klaassen CD. Regulation of hepatic bile acid transporters Ntcp and Bsep expression.
Biochem. Pharmacol. 74: 1665-1676 (2007).
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Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.
Drug Metab. Dispos. 32: 734-741 (2004).
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Chiang JY. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.
J. Hepatol. 40: 539-551 (2004).
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Choudhuri S, Cherrington NJ, Li N, Klaassen CD. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats.
Drug Metab. Dispos. 31: 1337-1345 (2003).
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Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. 1alpha,25-Dihydroxyvitamin D3 triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.
Biopharm. Drug Dispos. 30: 457-475 (2009).
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Colombo C, Okolicsanyi L, Strazzabosco M. Advances in familial and congenital cholestatic diseases. Clinical and diagnostic implications.
Dig. Liver Dis. 32: 152-159 (2000).
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Crocenzi FA, Basiglio CL, Perez LM, Portesio MS, Pozzi EJ, Roma MG. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP.
Biochem. Pharmacol. 69: 1113-1120 (2005).
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Crocenzi FA, Mottino AD, Cao J, Veggi LM, Pozzi EJ, Vore M, Coleman R, Roma MG. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats.
Am. J. Physiol. Gastrointest. Liver Physiol. 285: G449-G459 (2003).
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Crocenzi FA, Mottino AD, Sanchez Pozzi EJ, Pellegrino JM, Rodriguez Garay EA, Milkiewicz P, Vore M, Coleman R, Roma MG. Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.
Gut 52: 1170-1177 (2003).
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Crocenzi FA, Sanchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat.
Hepatology 48: 1885-1895 (2008).
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Csanaky IL, Aleksunes LM, Tanaka Y, Klaassen CD. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.
Am. J. Physiol. Gastrointest. Liver Physiol. 297: G419-G433 (2009).
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Cuesta de Juan S, Monte MJ, Macias RI, Wauthier V, Buc Calderon P, Marin JJ. Ontogenic development and effect of weaning on the expression of enzymes, transporters and nuclear receptors involved in rat bile acid homeostasis.
J. Lipid Res. 48: 1362-1370 (2007).
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Cui J, Heard TS, Yu J, Lo JL, Huang L, Li Y, Schaeffer JM, Wright SD. The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.
J. Biol. Chem. 277: 25963-25969 (2002).
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Cui J, Huang L, Zhao A, Lew JL, Yu J, Sahoo S, Meinke PT, Royo I, Pelaez F, Wright SD. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.
J. Biol. Chem. 278: 10214-10220 (2003).
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Cui J, Lew J-L, Zhao A, Huang L, Wright SD. The farnesoid X receptor controls gene expression in a ligand and promoter-selective fashion.
Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 32. June 18-19 (2004). *
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Cui T, Liu Y, Men X, Xu Z, Wu L, Liu S, Xing A. Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy.
Saudi Med. J. 30: 1406-1410 (2009).
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Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Toxicol. Sci. 110: 47-60 (2009).
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Davis RA, Attie AD. Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool.
Proc. Natl. Acad. Sci. U.S.A. 105: 4965-4966 (2008).
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Davit-Spraul A, Gonzales E, Baussan C, Jacquemin E. Progressive familial intrahepatic cholestasis.
Orphanet J. Rare Dis. 4: 1 (2009).
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Dawson PA, Lan T, Rao A. Bile acid transporters.
J. Lipid Res. 50: 2340-2357 (2009).
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Day C, Hewins P, Sheikh L, Kilby M, McPake D, Lipkin G. Cholestasis in pregnancy associated with ciclosporin therapy in renal transplant recipients.
Transpl. Int. 19: 1026-1029 (2006).
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de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM, Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, Coogan TP, Coussement WC, Mannens GS. The ontogeny of drug metabolizing enzymes and transporters in the rat.
Reprod. Toxicol. 26: 220-230 (2008).
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Demeilliers C, Jacquemin E, Barbu V, Mergey M, Paye F, Fouassier L, Chignard N, Housset C, Lomri NE. Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation.
Hepatology 43: 1125-1134 (2006).
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Deng R. Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits.
Cardiovasc. Drug Rev. 25: 375-390 (2007).
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Deng R, Yang D, Radke A, Yang J, Yan B. Hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over FXR-mediated antagonism.
J. Pharmacol. Exp. Ther. 320: 1153-1162 (2007).
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Deng R, Yang D, Yang J, Yan B. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor FXR but not LXR.
J. Pharmacol. Exp. Ther. 317: 317-325 (2006).
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Diaz GJ. Basolateral and canalicular transport of xenobiotics in the hepatocyte: a review.
Cytotechnology 34: 225-235 (2000).
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Dixon PH, van Mil S, Chambers J, Strautnieks S, Thompson R, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore G, Linton K, Williamson C. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy.
Gut 58: 537-544 (2009).
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Dombrowski F, Stieger B, Beuers U. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver.
Lab. Invest. 86: 166-174 (2006).
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Donner MG, Schumacher S, Warskulat U, Heinemann J, Haussinger D. Obstructive cholestasis induces TNF-alpha- and IL-1beta-mediated periportal down-regulation of Bsep and zonal regulation of Ntcp, Oatp1a4 and Oatp1b2.
Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1134-G1146 (2007).
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Dransfeld O, Gehrmann T, Kohrer K, Kircheis G, Holneicher C, Haussinger D, Wettstein M. Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver.
Liver Int. 25: 1243-1258 (2005).
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Dubrac S, Lear SR, Ananthanarayanan M, Balasubramaniyan N, Bollineni J, Shefer S, Hyogo H, Cohen DE, Blanche PJ, Krauss RM, Batta AK, Salen G, Suchy FJ, Maeda N, Erickson SK. Role of CYP27A in cholesterol and bile acid metabolism.
J. Lipid Res. 46: 76-85 (2005).
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Elamiri A, Perwaiz S, Tuchweber B, Yousef IM. Effect of mdr2 mutation with combined tandem disruption of canalicular glycoprotein transporters by cyclosporine A on bile formation in mice.
Pharmacol. Res. 48: 467-472 (2003).
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Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, Meijer DK, Groothuis GM. LPS-induced down-regulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
Am. J. Physiol. Gastrointest. Liver Physiol. 287: G1008-G1016 (2004).
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Eloranta JJ, Kullak-Ublick GA. Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism.
Arch. Biochem. Biophys. 433: 397-412 (2005).
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Eloranta ML, Hakli T, Hiltunen M, Helisalmi S, Punnonen K, Heinonen S. Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy.
Scand. J. Gastroenterol. 38: 648-652 (2003).
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Emerick KM, Elias ME, Melin-Aldana H, Strautnieks S, Thompson RJ, Bull LN, Knisely AS, Whitington PF, Green RM. Bile composition in Alagille syndrome and PFIC patients having partial external biliary diversion.
BMC Gastroenterol. 8: 47 (2008).
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Englert C, Grabhorn E, Richter A, Rogiers X, Burdelski M, Ganschow R. Liver transplantation in children with progressive familial intrahepatic cholestasis.
Transplantation 84: 1361-1363 (2007).
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Erickson RP, Bhattacharyya A, Hunter RJ, Heidenreich RA, Cherrington NJ. Liver disease with altered bile acid transport in Niemann-Pick C mice on a high fat, 1% cholesterol diet.
Am. J. Physiol. Gastrointest. Liver Physiol. 289: G300-G307 (2005).
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Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G. Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
J. Lipid Res. 44: 1001-1009 (2003).
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Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V. Regulation of biliary drug efflux pump expression by hormones and xenobiotics.
Toxicology 167: 37-46 (2001).
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Fattinger K, Funk C, Pantze M, Weber C, Reichen J, Stieger B, Meier PJ. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions.
Clin. Pharmacol. Ther. 69: 223-231 (2001).
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Favre N, Abergel A, Blanc P, Sapin V, Roszyk L, Gallot D. Unusual presentation of severe intrahepatic cholestasis of pregnancy leading to fetal death.
Obstet. Gynecol. 114: 491-493 (2009).
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Fayard E, Schoonjans K, Auwerx J. Xol INXS: role of the liver X and the farnesol X receptors.
Curr. Opin. Lipidol. 12: 113-120 (2001).
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Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB, Campbell S, Kostrubsky VE, Dunn MC, Smith AR, Wang HF. Role of hepatic transporters in the disposition and hepatotoxicity of a Her2 tyrosine kinase inhibitor CP-724,714.
Toxicol. Sci. 108: 492-500 (2009).
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Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K, Jaeschke H, Denk H, Trauner M. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
Am. J. Pathol. 168: 410-422 (2006).
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Fickert P, Stoger U, Fuchsbichler A, Moustafa T, Marschall HU, Weiglein AH, Tsybrovskyy O, Jaeschke H, Zatloukal K, Denk H, Trauner M. A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Am. J. Pathol. 171: 525-536 (2007).
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Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver.
Gastroenterology 121: 170-183 (2001).
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Figge A, Lammert F, Paigen B, Henkel A, Matern S, Korstanje R, Shneider BL, Chen F, Stoltenberg E, Spatz K, Hoda F, Cohen DE, Green RM. Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis.
J. Biol. Chem. 279: 2790-2799 (2004).
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Figge A, Matern S, Lammert F. Molecular genetics of cholesterol cholelithiasis: identification of human and murine gallstone genes.
Z. Gastroenterol. 40: 425-432 (2002).
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Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour B, Sabatino G, Russo G, Castellani D, Willson TM, Pellicciari R, Morelli A. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor (FXR) ligand, in estrogen induced cholestasis.
J. Pharmacol. Exp. Ther. 313: 604-612 (2005).
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Fitzgerald ML, Moore KJ, Freeman MW. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.
J. Mol. Med. 80: 271-281 (2002).
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Fouassier L, Beaussier M, Schiffer E, Rey C, Barbu V, Mergey M, Wendum D, Callard P, Scoazec JY, Lasnier E, Stieger B, Lienhart A, Housset C. Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes.
Am. J. Physiol. Gastrointest. Liver Physiol. 293: G25-G35 (2007).
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Frankenberg T, Miloh T, Chen FY, Ananthanarayanan M, Sun AQ, Balasubramaniyan N, Arias I, Setchell KD, Suchy FJ, Shneider BL. The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.
Hepatology 48: 1896-1905 (2008).
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Fujino T, Murakami K, Ozawa I, Minegishi Y, Kashimura R, Akita T, Saitou S, Atsumi T, Sato T, Ando K, Hara S, Kikugawa K, Hayakawa M. Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway.
FEBS J. 276: 1319-1332 (2009).
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Funk C. The role of hepatic transporters in drug elimination.
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David and Judy Rhodes
Last Update: 3/8/2010
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