• Akashi M, Tanaka A, Takikawa H 2006 Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats. Hepatol. Res. 34: 193-198.

• Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y 2001 Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta 1511: 7-16. *

• Albrecht C, Elliott JI, Sardini A, Litman T, Stieger B, Meier PJ, Higgins CF 2002 Functional analysis of candidate ABC transporter proteins for sitosterol transport. Biochim. Biophys. Acta 1567: 133-142. *

• Alrefai WA, Gill RK 2007 Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm. Res. 24: 1803-1823. *

• Alvarez L, Jara P, Sanchez-Sabate E, Hierro L, Larrauri J, Diaz MC, Camarena C, De La Vega A, Frauca E, Lopez-Collazo E, Lapunzina P 2004 Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1. Hum. Mol. Genet. 13: 2451-2460. *

• Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ 2001 Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J. Biol. Chem. 276: 28857-28865. *

• Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy FJ, Walsh MJ 2004 Ligand-dependent activation of the farnesoid-X-receptor directs arginine methylation of histone H3 by CARM1. J. Biol. Chem. 279: 54348-54357. *

• Arrese M 2006 Cholestasis during pregnancy: rare hepatic diseases unmasked by pregnancy. Ann. Hepatol. 5: 216-218. *

• Arrese M, Ananthanarayanan M 2004 The bile salt export pump: molecular properties, function and regulation. Pflugers Arch. 449: 123-131. *

• Asamoto Y, Tazuma S, Ochi H, Chayama K, Suzuki H 2001 Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. Biochem. J. 359: 605-610. *

• Balistreri WF 2003 Genetic liver disease. 54th Annual Meeting of the American Association for the Study of Liver Diseases.

• Ballatori N, Henson JH, Seward DJ, Cai SY, Runnegar M, Fricker G, Miller DS, Boyer JL 2006 Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 144: 167-179. *

• Ballatori N, Rebbeor JF, Connolly GC, Seward DJ, Lenth BE, Henson JH, Sundaram P, Boyer JL 2000 Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G57-G63. *

• Beilke LD, Besselsen DG, Cheng Q, Kulkarni S, Slitt AL, Cherrington NJ 2008 Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. Toxicol. Sci. 102: 196-204. *

• Bergasa NV, Mason A, Floreani A, Heathcote J, Swain MG, Jones DE, Lindor KM, Bassendine MF, Worman HJ 2004 Primary biliary cirrhosis: report of a focus study group. Hepatology 40: 1013-1020. *

• Beuers U 2003 Mechanisms of action of ursodeoxycholic acid in cholestasis. Falk Symposium 136. XII FALK LIVER WEEK 2003 (Part I) In Honour of Hans Popper’s 100th Birthday. Cholestatic Liver Diseases: Therapeutical Options and Perspectives. Freiburg (Germany). p. 49-50. October 15-16. *

• Beuers U 2006 Mechanisms of action of ursodeoxycholic acid for treatment of primary sclerosing cholangitis. Falk Workshop "Primary Sclerosing Cholangitis: Complications and Consequences", Moscow (Russia), June 11, 2006, p. 12. *

• Beuers U, Hohenester S, Wimmer R, Denk GU, Rust C 2004 Mitogen activated protein kinases and protein kinase C: short-term mediators of the anticholestatic effect of tauroursodeoxycholic acid in bile acid-induced cholestasis? Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 61. June 18-19. *

• Bi YA, Kazolias DC, Duignan DB 2006 Use of cryopreserved human hepatocytes in sandwich-culture to measure hepatobiliary transport. Drug Metab. Dispos. 34: 1658-1665. *

• Bode KA, Donner MG, Leier I, Keppler D 2002 Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem. Pharmacol. 64: 151-158. *

• Bohan A, Chen WS, Denson LA, Held MA, Boyer JL 2003 Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J. Biol. Chem. 278: 36688-36698. *

• Bohme M, Jedlitschky G, Leier I, Buchler M, Keppler D 1994 ATP-dependent export pumps and their inhibition by cyclosporins. Adv. Enzyme Regul. 34: 371-380.

• Bohme M, Muller M, Leier I, Jedlitschky G, Keppler D 1994 Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107: 255-265.

• Bolder U, Jeschke MG, Landmann L, Wolf F, de Sousa C, Schlitt HJ, Przkora R 2006 Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Cell Stress Chaperones 11: 89-100. *

• Bolder U, Schmidt A, Landmann L, Kidder V, Tange S, Jauch KW 2002 Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism. Gastroenterology 122: 963-973. *

• Boyer JL 2005 Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease? Gastroenterology 129: 735-740. *

• Boyer JL, Denk G, Bohan A, Chen WS, Soroka C, Denson L 2004 Adaptive regulation of bile salt transporters in cholestasis. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 46-47. June 18-19. *

• Byrne JA, Strautnieks SS, Ihrke G, Knisely AS, Jirsa M, Cebecauerova D, Linton KJ, Higgins CF, Mieli-Vergani G, Thompson RJ 2006 Investigation of the disease mechanisms associated with missense mutations in the bile salt export pump, BSEP. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 61. *

• Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ 2002 The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology 123: 1649-1658. *

• Cai SY, Boyer JL 2006 FXR: a target for cholestatic syndromes? Expert Opin. Ther. Targets 10: 409-421.

• Cai SY, Wang L, Ballatori N, Boyer JL 2001 Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G316-G322. *

• Cantz T, Nies AT, Brom M, Hofmann AF, Keppler D 2000 MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G522-G531. *

• Carlton VE, Pawlikowska L, Bull LN 2004 Molecular basis of intrahepatic cholestasis. Ann. Med. 36: 606-617.

• Carter BA, Prendergast DR, Taylor OA, Zimmerman TL, Furstenberg RV, Moore DD, Karpen SJ 2007 Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr. Res. 62: 301-306.

• Cassio D, Macias RI, Grosse B, Marin JJ, Monte MJ 2007 Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10. Cell Tissue Res. 330: 447-460. *

• Cavestro GM, Frulloni L, Cerati E, Ribeiro LA, Corrente V, Sianesi M, Franze A, Di Mario F 2002 Progressive familial intrahepatic cholestasis. Acta Biomed. Ateneo. Parmense. 73: 53-56.

• Chandra P, Brouwer KL 2004 The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharm. Res. 21: 719-735. *

• Chen HL, Chen HL, Liu YJ, Feng CH, Wu CY, Shyu MK, Yuan RH, Chang MH 2005 Developmental expression of canalicular transporter genes in human liver. J. Hepatol. 43: 472-477. *

• Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Tseng HC, Jeng YM, Chang MH 2008 Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr. Res. 63: 667-673.

• Chen HL, Liu YJ, Su YN, Wang NY, Wu SH, Ni YH, Hsu HY, Wu TC, Chang MH 2008 Diagnosis of BSEP/ABCB11 mutations in Asian patients with cholestasis using denaturing high performance liquid chromatography. J. Pediatr. Aug 8 [Epub ahead of print]. *

• Chen HL, Wang R, Chen HL, Hwu WL, Jeng YM, Chang MH, Ling V 2008 Bone marrow transplantation results in donor-derived hepatocytes in an animal model of inherited cholestatic liver disease. J. Biomed. Sci. May 29 [Epub ahead of print]. *

• Chen J, Raymond K 2006 Treatment effect of rifampicin on cholestasis. The Internet Journal of Pharmacology Vol. 4 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol4n2/colestasis.xml).

• Cheng X, Buckley D, Klaassen CD 2007 Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem. Pharmacol. 74: 1665-1676. *

• Cherrington NJ, Slitt AL, Li N, Klaassen CD 2004 Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab. Dispos. 32: 734-741. *

• Chiang JY 2004 Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J. Hepatol. 40: 539-551. *

• Choudhuri S, Cherrington NJ, Li N, Klaassen CD 2003 Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab. Dispos. 31: 1337-1345. *

• Colombo C, Okolicsanyi L, Strazzabosco M 2000 Advances in familial and congenital cholestatic diseases. Clinical and diagnostic implications. Dig. Liver Dis. 32: 152-159.

• Crocenzi FA, Basiglio CL, Perez LM, Portesio MS, Pozzi EJ, Roma MG 2005 Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP. Biochem. Pharmacol. 69: 1113-1120. *

• Crocenzi FA, Mottino AD, Cao J, Veggi LM, Pozzi EJ, Vore M, Coleman R, Roma MG 2003 Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G449-G459. *

• Crocenzi FA, Mottino AD, Sanchez Pozzi EJ, Pellegrino JM, Rodriguez Garay EA, Milkiewicz P, Vore M, Coleman R, Roma MG 2003 Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat. Gut 52: 1170-1177. *

• Cuesta de Juan S, Monte MJ, Macias RI, Wauthier V, Buc Calderon P, Marin JJ 2007 Ontogenic development and effect of weaning on the expression of enzymes, transporters and nuclear receptors involved in rat bile acid homeostasis. J. Lipid Res. 48: 1362-1370. *

• Cui J, Heard TS, Yu J, Lo JL, Huang L, Li Y, Schaeffer JM, Wright SD 2002 The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. J. Biol. Chem. 277: 25963-25969. *

• Cui J, Huang L, Zhao A, Lew JL, Yu J, Sahoo S, Meinke PT, Royo I, Pelaez F, Wright SD 2003 Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J. Biol. Chem. 278: 10214-10220. *

• Cui J, Lew J-L, Zhao A, Huang L, Wright SD 2004 The farnesoid X receptor controls gene expression in a ligand and promoter-selective fashion. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 32. June 18-19. *

• Davis RA, Attie AD 2008 Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool. Proc. Natl. Acad. Sci. U.S.A. 105: 4965-4966. *

• Day C, Hewins P, Sheikh L, Kilby M, McPake D, Lipkin G 2006 Cholestasis in pregnancy associated with ciclosporin therapy in renal transplant recipients. Transpl. Int. 19: 1026-1029. *

• Demeilliers C, Jacquemin E, Barbu V, Mergey M, Paye F, Fouassier L, Chignard N, Housset C, Lomri NE 2006 Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation. Hepatology 43: 1125-1134. *

• Deng R 2007 Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovasc. Drug Rev. 25: 375-390.

• Deng R, Yang D, Radke A, Yang J, Yan B 2007 Hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over FXR-mediated antagonism. J. Pharmacol. Exp. Ther. 320: 1153-1162. *

• Deng R, Yang D, Yang J, Yan B 2006 Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor FXR but not LXR. J. Pharmacol. Exp. Ther. 317: 317-325. *

• Dombrowski F, Stieger B, Beuers U 2006 Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab. Invest. 86: 166-174. *

• Donner MG, Schumacher S, Warskulat U, Heinemann J, Haussinger D 2007 Obstructive cholestasis induces TNF-alpha- and IL-1beta-mediated periportal down-regulation of Bsep and zonal regulation of Ntcp, Oatp1a4 and Oatp1b2. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1134-G1146. *

• Dransfeld O, Gehrmann T, Kohrer K, Kircheis G, Holneicher C, Haussinger D, Wettstein M 2005 Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver. Liver Int. 25: 1243-1258. *

• Dubrac S, Lear SR, Ananthanarayanan M, Balasubramaniyan N, Bollineni J, Shefer S, Hyogo H, Cohen DE, Blanche PJ, Krauss RM, Batta AK, Salen G, Suchy FJ, Maeda N, Erickson SK 2005 Role of CYP27A in cholesterol and bile acid metabolism. J. Lipid Res. 46: 76-85. *

• Elamiri A, Perwaiz S, Tuchweber B, Yousef IM 2003 Effect of mdr2 mutation with combined tandem disruption of canalicular glycoprotein transporters by cyclosporine A on bile formation in mice. Pharmacol. Res. 48: 467-472. *

• Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, Meijer DK, Groothuis GM 2004 LPS-induced down-regulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G1008-G1016. *

• Eloranta JJ, Kullak-Ublick GA 2005 Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. Arch. Biochem. Biophys. 433: 397-412. *

• Eloranta ML, Hakli T, Hiltunen M, Helisalmi S, Punnonen K, Heinonen S 2003 Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. Scand. J. Gastroenterol. 38: 648-652. *

• Englert C, Grabhorn E, Richter A, Rogiers X, Burdelski M, Ganschow R 2007 Liver transplantation in children with progressive familial intrahepatic cholestasis. Transplantation 84: 1361-1363.

• Erickson RP, Bhattacharyya A, Hunter RJ, Heidenreich RA, Cherrington NJ 2005 Liver disease with altered bile acid transport in Niemann-Pick C mice on a high fat, 1% cholesterol diet. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G300-G307. *

• Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G 2003 Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J. Lipid Res. 44: 1001-1009. *

• Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V 2001 Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology 167: 37-46. *

• Fattinger K, Funk C, Pantze M, Weber C, Reichen J, Stieger B, Meier PJ 2001 The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin. Pharmacol. Ther. 69: 223-231. *

• Fayard E, Schoonjans K, Auwerx J 2001 Xol INXS: role of the liver X and the farnesol X receptors. Curr. Opin. Lipidol. 12: 113-120.

• Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K, Jaeschke H, Denk H, Trauner M 2006 Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am. J. Pathol. 168: 410-422. *

• Fickert P, Stoger U, Fuchsbichler A, Moustafa T, Marschall HU, Weiglein AH, Tsybrovskyy O, Jaeschke H, Zatloukal K, Denk H, Trauner M 2007 A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. Am. J. Pathol. 171: 525-536. *

• Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M 2001 Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 121: 170-183. *

• Figge A, Lammert F, Paigen B, Henkel A, Matern S, Korstanje R, Shneider BL, Chen F, Stoltenberg E, Spatz K, Hoda F, Cohen DE, Green RM 2004 Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J. Biol. Chem. 279: 2790-2799. *

• Figge A, Matern S, Lammert F 2002 Molecular genetics of cholesterol cholelithiasis: identification of human and murine gallstone genes. Z. Gastroenterol. 40: 425-432.

• Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour B, Sabatino G, Russo G, Castellani D, Willson TM, Pellicciari R, Morelli A 2005 Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor (FXR) ligand, in estrogen induced cholestasis. J. Pharmacol. Exp. Ther. 313: 604-612. *

• Fitzgerald ML, Moore KJ, Freeman MW 2002 Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J. Mol. Med. 80: 271-281. *

• Fouassier L, Beaussier M, Schiffer E, Rey C, Barbu V, Mergey M, Wendum D, Callard P, Scoazec JY, Lasnier E, Stieger B, Lienhart A, Housset C 2007 Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G25-G35. *

• Frankenberg T, Miloh T, Chen FY, Ananthanarayanan M, Sun AQ, Balasubramaniyan N, Arias I, Setchell KD, Suchy FJ, Shneider BL 2008 The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor. Hepatology May 27 [Epub ahead of print].

• Funk C, Ponelle C, Scheuermann G, Pantze M 2001 Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol. Pharmacol. 59: 627-635. *

• Gao B, St Pierre MV, Stieger B, Meier PJ 2004 Differential expression of bile salt and organic anion transporters in developing rat liver. J. Hepatol. 41: 201-208. *

• Geier A, Dietrich CG, Grote T, Beuers U, Prufer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M 2005 Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J. Hepatol. 43: 1021-1030. *

• Geier A, Dietrich CG, Lammert F, Orth T, Mayet WJ, Matern S, Gartung C 2002 Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis. J. Hepatol. 36: 718-724. *

• Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, Suchy FJ, Matern S, Gartung C 2005 Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G831-G841. *

• Geier A, Kim SK, Gerloff T, Dietrich CG, Lammert F, Karpen SJ, Stieger B, Meier PJ, Matern S, Gartung C 2002 Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J. Hepatol. 37: 198-205. *

• Geier A, Wagner M, Dietrich CG, Trauner M 2007 Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim. Biophys. Acta 1773: 283-308. *

• Gerloff T, Geier A, Roots I, Meier PJ, Gartung C 2002 Functional analysis of the rat bile salt export pump gene promoter. Eur. J. Biochem. 269: 3495-3503. *

• Gerloff T, Geier A, Stieger B, Hagenbuch B, Meier PJ, Matern S, Gartung C 1999 Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. Gastroenterology 117: 1408-1415. *

• Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ 1998 The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J. Biol. Chem. 273: 10046-10050. *

• Geuken E, Visser D, Kuipers F, Blokzijl H, Leuvenink HG, de Jong KP, Peeters PM, Jansen PL, Slooff MJ, Gouw AS, Porte RJ 2004 Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation. J. Hepatol. 41: 1017-1025. *

• Geuken E, Visser DS, Leuvenink HG, de Jong KP, Peeters PM, Slooff MJ, Kuipers F, Porte RJ 2005 Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients. Hepatology 42: 1166-1174. *

• Glantz A, Benthin L, Lammert F, Mattsson LA, Marschall HU 2006 Disulfated progesterone metabolites in urine relate to pruritus in intrahepatic cholestasis of pregnancy treated with ursodeoxycholic acid. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 62. *

• Gorelik J, Patel P, Ng'andwe C, Vodyanoy I, Diakonov I, Lab M, Korchev Y, Williamson C 2006 Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture. BJOG 113: 552-558. *

• Goto K, Sugiyama K, Sugiura T, Ando T, Mizutani F, Terabe K, Ban K, Togari H 2003 Bile salt export pump gene mutations in two Japanese patients with progressive familial intrahepatic cholestasis. J. Pediatr. Gastroenterol. Nutr. 36: 647-650. *

• Gradilone SA, Tietz PS, Splinter PL, Marinelli RA, LaRusso NF 2005 Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B. BMC Physiol. 5: 13. *

• Green RM, Hoda F, Ward KL 2000 Molecular cloning and characterization of the murine bile salt export pump. Gene 241: 117-123. *

• Hagenbuch N, Reichel C, Stieger B, Cattori V, Fattinger KE, Landmann L, Meier PJ, Kullak-Ublick GA 2001 Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J. Hepatol. 34: 881-887. *

• Hannivoort RA, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, Buist-Homan M, van den Heuvel FA, Geuken M, Geerts A, Roskams T, Faber KN, Moshage H 2008 Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology 48: 624-634.

• Harris MJ, Kagawa T, Dawson PA, Arias IM 2004 Taurocholate transport by hepatic and intestinal bile acid transporters is independent of FIC1 overexpression in Madin-Darby canine kidney cells. J. Gastroenterol. Hepatol. 19: 819-825. *

• Harris MJ, LE Couteur DG, Arias IM 2005 Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. J. Gastroenterol. Hepatol. 20: 807-817. *

• Hartmann G, Cheung AK, Piquette-Miller M 2002 Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J. Pharmacol. Exp. Ther. 303: 273-281. *

• Hayashi H, Sugiyama Y 2007 4-Phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. Hepatology 45: 1506-1516. *

• Hayashi H, Takada T, Suzuki H, Akita H, Sugiyama Y 2005 Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. Hepatology 41: 916-924. *

• Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, Sugiyama Y 2005 Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim. Biophys. Acta 1738: 54-62. *

• Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM 2005 Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26: 219-227. *

• Heemskerk S, van Koppen A, van den Broek L, Poelen GJ, Wouterse AC, Dijkman HB, Russel FG, Masereeuw R 2007 Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Pflugers Arch. 454: 321-334. *

• Henriquez-Hernandez LA, Flores-Morales A, Santana-Farre R, Axelson M, Nilsson P, Norstedt G, Fernandez-Perez L 2007 Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat. J. Pharmacol. Exp. Ther. 320: 695-705. *

• Hermeziu B, Sanlaville D, Girard M, Leonard C, Lyonnet S, Jacquemin E 2006 Heterozygous bile salt export pump deficiency: a possible genetic predisposition to transient neonatal cholestasis. J. Pediatr. Gastroenterol. Nutr. 42: 114-116. *

• Hierro L, Jara P 2005 Childhood cholestasis and bile transporters. Gastroenterol. Hepatol. 28: 388-395.

• Hirano H, Kurata A, Onishi Y, Sakurai A, Saito H, Nakagawa H, Nagakura M, Tarui S, Kanamori Y, Kitajima M, Ishikawa T 2006 High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis. Mol. Pharm. 3: 252-265. *

• Hirano M, Maeda K, Hayashi H, Kusuhara H, Sugiyama Y 2005 Bile salt export pump (BSEP/ABCB11) can transport a non-bile acid substrate, pravastatin. J. Pharmacol. Exp. Ther. 314: 876-882. *

• Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y 2000 ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J. Biol. Chem. 275: 2905-2910. *

• Hoda F, Green RM 2003 Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation. J. Membr. Biol. 196: 9-14. *

• Hofmann AF 2007 Biliary secretion and excretion in health and disease: current concepts. Ann. Hepatol. 6: 15-27. *

• Hojo M, Sano N, Takikawa H 2003 Effects of lipopolysaccharide on the biliary excretion of bile acids and organic anions in rats. J. Gastroenterol. Hepatol. 18: 815-821. *

• Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Hirayama T, Tint GS, Doy M, Shefer S 2005 Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. J. Lipid Res. 46: 287-296. *

• Honjo Y, Sasaki S, Kobayashi Y, Misawa H, Nakamura H 2006 1,25-Dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. J. Endocrinol. 188: 635-643. *

• Horikawa M, Kato Y, Tyson CA, Sugiyama Y 2004 Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab. Pharmacokinet. 18: 16-22. *

• Huang L, Smit JW, Meijer DK, Vore M 2000 Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. Hepatology 32: 66-72. *

• Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, de Pedro N, Royo I, Blevins RA, Pelaez F, Wright SD, Cui J 2003 Farnesoid X receptor activates transcription of the phospholipid pump MDR3. J. Biol. Chem. 278: 51085-51090. *

• Hyogo H, Tazuma S, Cohen DE 2002 Cholesterol gallstones. Curr. Opin. Gastroenterol. 18: 366-371.

• Hyogo H, Tazuma S, Nishioka T, Ochi H, Yamaguchi A, Numata Y, Kanno K, Sakomoto M, Asamoto Y, Tsuboi K, Nakai K, Yasumiba S, Sunami Y, Kajiyama G 2001 Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model. Dig. Dis. Sci. 46: 2089-2097. *

• Inokuchi A, Hinoshita E, Iwamoto Y, Kohno K, Kuwano M, Uchiumi T 2001 Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter. J. Biol. Chem. 276: 46822-46829. *

• Iwanaga T, Nakakariya M, Yabuuchi H, Maeda T, Tamai I 2007 Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis. Biol. Pharm. Bull. 30: 739-744. *

• Jacquemin E 2000 Progressive familial intrahepatic cholestasis. Genetic basis and treatment. Clin. Liver Dis. 4: 753-763.

• Jansen PL 2000 The pathophysiology of cholestasis with special reference to primary biliary cirrhosis. Baillieres Best Pract. Res. Clin. Gastroenterol. 14: 571-583.

• Jansen PL 2006 Genetics of cholestasis. Falk Symposium 156. XIII Falk Liver Week (Part II). GENETICS IN LIVER DISEASES, Freiburg (Germany), October 8-9, 2006, p. 37-40. *

• Jansen PL, Muller M, Kuipers F 2000 Bile formation and cholestasis. Ned. Tijdschr. Geneeskd. 144: 2384-2391.

• Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ, Koning JH, De Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CM, Gouw A, Van Goor H, Thompson RJ, Muller M 1999 Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology 117: 1370-1379. *

• Jansen PL, Sturm E 2003 Genetic cholestasis, causes and consequences for hepatobiliary transport. Liver Int. 23: 315-322. *

• Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O 2006 Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab. Dispos. 34: 1756-1763. *

• Johnson BM, Zhang P, Schuetz JD, Brouwer KL 2006 Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metab. Dispos. 34: 556-562. *

• Josse R, Aninat C, Glaise D, Dumont J, Fessard V, Morel F, Poul JM, Guguen-Guillouzo C, Guillouzo A 2008 Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab. Dispos. 36: 1111-1118. *

• Jung D, Elferink MG, Stellaard F, Groothuis GM 2007 Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int. 27: 137-144. *

• Kadmon M, Klunemann C, Bohme M, Ishikawa T, Gorgas K, Otto G, Herfarth C, Keppler D 1993 Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology 104: 1507-1514.

• Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, Tanaka H, Arias IM, Mine T 2008 Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G58-G67. *

• Kanno K, Tazuma S, Niida S, Chayama K 2003 Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction. Hepatol. Res. 26: 157-163.

• Kaplowitz N 2004 Hepatology highlights. Hepatology 39: 271-272. *

• Karlsen TH, Boberg KM, Schrumpf E 2006 Role of polymorphisms in genes involved in bile acid detoxification pathways in primary sclerosing cholangitis. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 87. *

• Kassam A, Miao B, Young PR, Mukherjee R 2003 Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. J. Biol. Chem. 278: 10028-10032. *

• Keitel V, Burdelski M, Warskulat U, Kuhlkamp T, Keppler D, Haussinger D, Kubitz R 2005 Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology 41: 1160-1172. *

• Keitel V, Vogt C, Haussinger D, Kubitz R 2006 Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology 131: 624-629. *

• Kemp DC, Zamek-Gliszczynski MJ, Brouwer KL 2005 Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. Toxicol. Sci. 83: 207-214. *

• Keppler D, Konig J, Buchler M 1997 The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. Adv. Enzyme Regul. 37: 321-333. *

• Keppler D, Leier I, Jedlitschky G 1997 Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol. Chem. 378: 787-791.

• Keppler D, Rius M 2006 The concept of basolateral efflux pumps of the hepatocyte. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 30-31. *

• Keppler D, Rius M, Nies AT 2004 Bile salt efflux mediated by multidrug resistance protein MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 38. June 18-19. *

• Kitada H, Miyata M, Nakamura T, Tozawa A, Honma W, Shimada M, Nagata K, Sinal CJ, Guo GL, Gonzalez FJ, Yamazoe Y 2003 Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. J. Biol. Chem. 278: 17838-17844. *

• Kivisto KT, Niemi M 2007 Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans. Pharm. Res. 24: 239-247. *

• Knisely AS 2000 Progressive familial intrahepatic cholestasis: a personal perspective. Pediatr. Dev. Pathol. 3: 113-125.

• Knisely AS, Strautnieks SS, Meier Y, Stieger B, Byrne JA, Portmann BC, Bull LN, Pawlikowska L, Bilezikci B, Ozcay F, Laszlo A, Tiszlavicz L, Moore L, Raftos J, Arnell H, Fischler B, Nemeth A, Papadogiannakis N, Cielecka-Kuszyk J, Jankowska I, et al 2006 Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency. Hepatology 44: 478-486. *

• Kok T, Bloks VW, Wolters H, Havinga R, Jansen PL, Staels B, Kuipers F 2003 Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem. J. 369: 539-547. *

• Kok T, Hulzebos CV, Wolters H, Havinga R, Agellon LB, Stellaard F, Shan B, Schwarz M, Kuipers F 2003 Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J. Biol. Chem. 278: 41930-41937. *

• Kondrackiene J, Beuers U, Kupcinskas L 2005 Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. Gastroenterology 129: 894-901. *

• Kong FM, Sui CY, Li YJ, Guo KJ, Guo RX 2006 Hepatobiliary membrane transporters involving in the formation of cholesterol calculus. Hepatobiliary Pancreat. Dis. Int. 5: 286-289. *

• Kosters A, Karpen SJ 2008 Bile acid transporters in health and disease. Xenobiotica 38: 1043-1071. *

• Kostrubsky SE, Strom SC, Kalgutkar AS, Kulkarni S, Atherton J, Mireles R, Kubik R, Hanson J, Urda E, Mutlib AE 2006 Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicol. Sci. 90: 451-459. *

• Kubitz R, Keitel V, Burdelski M, Haussinger D 2006 Regulation of hepatobiliary transporters in chronic cholestasis. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 33-35. *

• Kubitz R, Keitel V, Scheuring S, Kohrer K, Haussinger D 2006 Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump. J. Clin. Gastroenterol. 40: 171-175.

• Kubitz R, Saha N, Kuhlkamp T, Dutta S, Vom Dahl S, Wettstein M, Haussinger D 2004 Ca2+-dependent protein kinase C-isoforms induce cholestasis in rat liver. J. Biol. Chem. 279: 10323-10330. *

• Kubitz R, Sutfels G, Kuhlkamp T, Kolling R, Haussinger D 2004 Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 126: 541-553. *

• Kullak-Ublick GA 2004 Regulation of bile salt transporter genes by nuclear receptors. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 43. June 18-19. *

• Kullak-Ublick GA 2006 Regulation of hepatic and intestinal bile acid transport by FXR controlled signaling pathways. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 51-52. *

• Kullak-Ublick GA, Beuers U, Paumgartner G 2000 Hepatobiliary transport. J. Hepatol. 32: S3-S18.

• Kullak-Ublick GA, Meier PJ 2000 Mechanisms of cholestasis. Clin. Liver Dis. 4: 357-385.

• Kullak-Ublick GA, Stieger B, Hagenbuch B, Meier PJ 2000 Hepatic transport of bile salts. Semin. Liver Dis. 20: 273-292. *

• Kullak-Ublick GA, Stieger B, Meier PJ 2004 Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126: 322-342. *

• Kurihara H, Sano N, Takikawa H 2005 Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis. J. Gastroenterol. Hepatol. 20: 1069-1074. *

• Kurz AK, Graf D, Schmitt M, Vom Dahl S, Haussinger D 2001 Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121: 407-419. *

• Labori KJ, Arnkvaern K, Bjornbeth BA, Press CM, Raeder MG 2002 Cholestatic effect of large bilirubin loads and cholestasis protection conferred by cholic acid co-infusion: a molecular and ultrastructural study. Scand. J. Gastroenterol. 37: 585-596. *

• Lam P, Pearson CL, Soroka C, Xu S, Mennone A, Boyer JL 2007 The level of plasma membrane expression in progressive and benign mutations of the bile salt export pump (BSEP/ABCB11) correlate with severity of cholestatic diseases. Am. J. Physiol. Cell. Physiol. 293: C1709-C1716. *

• Lam P, Wang R, Ling V 2005 Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry 44: 12598-12605. *

• Lammert F, Marschall HU, Matern S 2003 Intrahepatic cholestasis of pregnancy. Curr. Treat. Options Gastroenterol. 6: 123-132.

• Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA 2006 The nuclear receptor for bile acids, FXR, transactivates the human organic solute transporter-alpha and -beta genes. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G476-G485. *

• Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C 2007 Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet. Genomics 17: 47-60.

• Lang T, Haberl M, Jung D, Drescher A, Schlagenhaufer R, Keil A, Mornhinweg E, Stieger B, Kullak-Ublick G, Kerb R 2006 Genetic variability, haplotype structures, and ethnical diversity of hepatic transporters MDR3 (ABCB4) and BSEP (ABCB11). Drug Metab. Dispos. 34: 1582-1599. *

• Lazaridis KN, LaRusso NF 2003 Bile formation: do not ignore the role of plasma membrane-cytoskeleton linking proteins. Hepatology 37: 218-220. *

• Le Vee M, Gripon P, Stieger B, Fardel O 2008 Down-regulation of organic anion transporter expression in human hepatocytes exposed to the pro-inflammatory cytokine interleukin-1beta. Drug Metab. Dispos. 36: 217-222. *

• Lecureur V, Courtois A, Payen L, Verhnet L, Guillouzo A, Fardel O 2000 Expression and regulation of hepatic drug and bile acid transporters. Toxicology 153: 203-219. *

• Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL 2000 Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 118: 163-172. *

• Lefkowitch JH 2007 Hepatobiliary pathology. Curr. Opin. Gastroenterol. 23: 221-231.

• Leslie EM, Watkins PB, Kim RB, Brouwer KL 2007 Differential inhibition of rat and human Na+-dependent taurocholate co-transporting polypeptide (NTCP/SLC10A1) by bosentan: a mechanism for species differences in hepatotoxicity. J. Pharmacol. Exp. Ther. 321: 1170-1178. *

• Levy E, Brunet S, Alvarez F, Seidman E, Bouchard G, Escobar E, Martin S 2007 Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Life Sci. 80: 1472-1483. *

• Lew JL, Zhao A, Yu J, Huang L, De Pedro N, Pelaez F, Wright SD, Cui J 2004 The farnesoid X receptor (FXR) controls gene expression in a ligand- and promoter- selective fashion. J. Biol. Chem. 279: 8856-8861. *

• Li H, Xu G, Shang Q, Pan L, Shefer S, Batta AK, Bollineni J, Tint GS, Keller BT, Salen G 2004 Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7alpha-hydroxylase. Metabolism 53: 927-932. *

• Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ 2007 Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab. Dispos. 35: 402-409. *

• Ling V, Lam P, Forrest D, Liu L, Wang R 2004 Bile acid transport in Spgp (BSEP) knockout mice. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 37. June 18-19. *

• Liu Y, Havinga R, van der Leij FR, Boverhof R, Sauer PJ, Kuipers F, Stellaard F 2008 Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics. Pediatr. Res. 63: 375-381.

• Ljubuncic P, Yousef I, Bomzon A 2004 Cholemic transgenic mice: a novel animal model to investigate the effects of bile acids. J. Pharmacol. Toxicol. Methods 50: 231-235. *

• Macias RI, Jimenez S, Serrano MA, Monte MJ, Marin JJ 2006 Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Life Sci. 79: 1014-1019. *

• Mano Y, Usui T, Kamimura H 2006 Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2. Biopharm. Drug Dispos. 28: 13-18. *

• Marin JJ, Macias RI, Briz O, Perez MJ, Serrano MA 2005 Molecular bases of the excretion of fetal bile acids and pigments through the fetal liver-placenta-maternal liver pathway. Ann. Hepatol. 4: 70-76.

• Marschall HU, Wagner M, Bodin K, Zollner G, Fickert P, Gumhold J, Silbert D, Fuchsbichler A, Sjovall J, Trauner M 2006 Fxr -/- mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. J. Lipid Res. 47: 582-592. *

• Marschall HU, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold J, Silbert D, Fuchsbichler A, Benthin L, Grundstrom R, Gustafsson U, Sahlin S, Einarsson C, Trauner M 2005 Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 129: 476-485. *

• Marschall HU, Wagner M, Zollner G, Fickert P, Gumhold J, Silbert D, Diczfalusy U, Benthin L, Grundstrom R, Gustafsson U, Sahlin S, Einarsson C, Trauner M 2004 Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 47. June 18-19. *

• Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F 2005 Liver fatty-acid-binding protein (L-FABP) gene ablation alters liver bile acid metabolism in male mice. Biochem. J. 391: 549-560. *

• Masubuchi Y 2006 Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review. Drug Metab. Pharmacokinet. 21: 347-356. *

• Matsushima S, Maeda K, Hayashi H, Debori Y, Schinkel AH, Schuetz JD, Kusuhara H, Sugiyama Y 2008 Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol. Pharmacol. 73: 1474-1483. *

• McRae MP, Lowe CM, Tian X, Bourdet DL, Ho RH, Leake BF, Kim RB, Brouwer KL, Kashuba AD 2006 Ritonavir, saquinavir and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes. J. Pharmacol. Exp. Ther. 318: 1068-1075. *

• Meier PJ, Stieger B 2002 Bile salt transporters. Annu. Rev. Physiol. 64: 635-661. *

• Meier Y, Pauli-Magnus C, Zanger UM, Klein K, Schaeffeler E, Nussler AK, Nussler N, Eichelbaum M, Meier PJ, Stieger B 2006 Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology 44: 62-74. *

• Meier Y, Zodan T, Lang C, Zimmermann R, Kullak-Ublick GA, Meier PJ, Stieger B, Pauli-Magnus C 2008 Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. World J. Gastroenterol. 14: 38-45. *

• Meier-Abt PJ 2003 Transport and metabolic functions. Falk Symposium 138. XII FALK LIVER WEEK 2003 (Part III) In Honour of Hans Popper’s 100th Birthday. State-of-the-art of hepatology: Molecular and Cell Biology. Freiburg (Germany). p. 21-22. October 20 - 21. *

• Mendoza ME, Monte MJ, Serrano MA, Pastor-Anglada M, Stieger B, Meier PJ, Medarde M, Marin JJ 2003 Physiological characteristics of allo-cholic acid. J. Lipid Res. 44: 84-92. *

• Micheline D, Emmanuel J, Serge E 2002 Effect of ursodeoxycholic acid on the expression of the hepatocellular bile acid transporters (Ntcp and bsep) in rats with estrogen-induced cholestasis. J. Pediatr. Gastroenterol. Nutr. 35: 185-191. *

• Mikami M, Takikawa H 2008 Effect of genipin on the biliary excretion of cholephilic compounds in rats. Hepatol. Res. 38: 614-621. *

• Mills CO, Milkiewicz P, Muller M, Roma MG, Havinga R, Coleman R, Kuipers F, Jansen PL, Elias E 1999 Different pathways of canalicular secretion of sulfated and non-sulfated fluorescent bile acids: a study in isolated hepatocyte couplets and TR- rats. J. Hepatol. 31: 678-684. *

• Misra S, Varticovski L, Arias IM 2003 Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G316-G324. *

• Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y 2006 Inhibition of bile acid transport across NTCP and BSEP co-expressing LLC-PK1 cells by cholestasis-inducing drugs. Drug Metab. Dispos. 34: 1575-1581. *

• Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y 2006 Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G550-G556. *

• Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y 2005 Vectorial transport of bile salts across MDCK cells expressing both rat Na+/taurocholate cotransporting polypeptide and rat bile salt export pump. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G159-G167. *

• Miyata M, Tozawa A, Otsuka H, Nakamura T, Nagata K, Gonzalez FJ, Yamazoe Y 2005 Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. J. Pharmacol. Exp. Ther. 312: 759-766. *

• Mizrahi M, Lalazar G, Horwich Y, Adar T, Safadi R 2008 Benign recurrent intrahepatic cholestasis type-II - a rare cause of direct hyperbilirubinemia exacerbations with hepatic fibrosis. Harefuah 147: 381-383, 480.

• Mochizuki K, Kagawa T, Numari A, Harris MJ, Itoh J, Watanabe N, Mine T, Arias IM 2007 Two N-linked glycans are required to maintain transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G818-G828. *

• Mock MR, Meier PJ, Stieger B 2004 Protein-protein interactions and their importance in the function of the canalicular bile salt export pump (Bsep). Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 35-36. June 18-19. *

• Monte MJ, Fernandez-Tagarro M, Macias RI, Jimenez F, Gonzalez-San Martin F, Marin JJ 2005 Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. Clin. Sci. (Lond.) 109: 199-207. *

• Moreno M, Molina H, Amigo L, Zanlungo S, Arrese M, Rigotti A, Miquel JF 2003 Hepatic overexpression of caveolins increases bile salt secretion in mice. Hepatology 38: 1477-1488. *

• Mottino AD, Veggi LM, Wood M, Roman JM, Vore M 2003 Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis. J. Pharmacol. Exp. Ther. 307: 306-313. *

• Muehlenberg K, Wiedmann K, Keppeler H, Sauerbruch T, Lammert F 2008 Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholitiasis in a female patient with stop codon in the ABCB4-gene of the hepatobiliary phospholipid transporter. Z. Gastroenterol. 46: 48-53.

• Muhlfeld A, Kubitz R, Dransfeld O, Haussinger D, Wettstein M 2003 Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis. Arch. Biochem. Biophys. 413: 32-40. *

• Muller O, Schalla C, Scheibner J, Stange EF, Fuchs M 2002 Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice. Biochem. J. 361: 673-679. *

• Nishimaki-Mogami T, Une M, Fujino T, Sato Y, Tamehiro N, Kawahara Y, Shudo K, Inoue K 2004 Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor. J. Lipid Res. 45 1538-1545. *

• Nishio N, Katsura T, Ashida K, Okuda M, Inui K 2005 Modulation of P-glycoprotein expression in hyperthyroid rat tissues. Drug Metab. Dispos. 33: 1584-1587. *

• Noe J, Hagenbuch B, Meier PJ, St-Pierre MV 2001 Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology 33: 1223-1231. *

• Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Mullhaupt B, Meier PJ, Pauli-Magnus C 2005 Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J. Hepatol. 43: 536-543. *

• Noe J, Stieger B, Meier PJ 2002 Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology 123: 1659-1666. *

• Nozawa H 2005 Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem. Biophys. Res. Commun. 336: 754-761. *

• O'Leary JG, Pratt DS 2007 Cholestasis and cholestatic syndromes. Curr. Opin. Gastroenterol. 23: 232-236.

• Okumura H, Katoh M, Minami K, Nakajima M, Yokoi T 2007 Change of drug excretory pathway by CCl(4)-induced liver dysfunction in rat. Biochem. Pharmacol. 74: 488-495. *

• Olinga P, Elferink MG, Draaisma AL, Merema MT, Castell JV, Perez G, Groothuis GM 2008 Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. Eur. J. Pharm. Sci. 33: 380-389. *

• Ortiz DF, Moseley J, Calderon G, Swift AL, Li S, Arias IM 2004 Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J. Biol. Chem. 279: 32761-32770. *

• Oshima H, Kon J, Ooe H, Hirata K, Mitaka T 2008 Functional expression of organic anion transporters in hepatic organoids reconstructed by rat small hepatocytes. J. Cell. Biochem. 104: 68-81. *

• Oude Elferink RP, Groen AK 2002 Genetic defects in hepatobiliary transport. Biochim. Biophys. Acta 1586: 129-145. *

• Oude Elferink RP, Ottenhoff R, Fricker G, Seward DJ, Ballatori N, Boyer J 2004 Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G762-G768. *

• Owsley E, Chiang JY 2003 Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. Biochem. Biophys. Res. Commun. 304: 191-195. *

• Painter JN, Savander M, Sistonen P, Lehesjoki AE, Aittomaki K 2004 A known polymorphism in the bile salt export pump gene is not a risk allele for intrahepatic cholestasis of pregnancy. Scand. J. Gastroenterol. 39: 694-695. *

• Paolini M, Pozzetti L, Montagnani M, Potenza G, Sabatini L, Antelli A, Cantelli-Forti G, Roda A 2002 Ursodeoxycholic acid (UDCA) prevents DCA effects on male mouse liver via up-regulation of CYP [correction of CXP] and preservation of BSEP activities. Hepatology 36: 305-314. *

• Park YJ, Qatanani M, Chua SS, Larey JL, Johnson SA, Watanabe M, Moore DD, Lee YK 2008 Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology 47: 1578-1586. *

• Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, Beuers U, Meier PJ 2004 BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 39: 779-791. *

• Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA 2004 Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics 14: 91-102.

• Pauli-Magnus C, Stieger B, Meier Y, Kullak-Ublick GA, Meier PJ 2005 Enterohepatic transport of bile salts and genetics of cholestasis. J. Hepatol. 43: 342-357. *

• Paumgartner G, Beuers U 2002 Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 36: 525-531. *

• Paus TC, Schneider G, Van De Vondel P, Sauerbruch T, Reichel C 2004 Diagnosis and therapy of intrahepatic cholestasis of pregnancy. Z. Gastroenterol. 42: 623-628.

• Pellicoro A, Faber KN 2007 Review article: the function and regulation of proteins involved in bile salt biosynthesis and transport. Aliment. Pharmacol. Ther. 26 Suppl. 2: 149-160. *

• Perez LM, Milkiewicz P, Elias E, Coleman R, Sanchez Pozzi EJ, Roma MG 2006 Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Toxicol. Sci. 91: 150-158. *

• Pizarro M, Balasubramaniyan N, Solis N, Solar A, Duarte I, Miquel JF, Suchy FJ, Trauner M, Accatino L, Ananthanarayanan M, Arrese M 2004 Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut 53: 1837-1843. *

• Plass JR, Mol O, Heegsma J, Geuken M, de Bruin J, Elling G, Muller M, Faber KN, Jansen PL 2004 A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. J. Hepatol. 40: 24-30. *

• Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, Muller M 2002 Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 35: 589-596. *

• Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van-Erpecum KJ, van-Berge-Henegouwen GP 2005 Primary sclerosing cholangitis: updates in diagnosis and therapy. World J. Gastroenterol. 11: 7-16. *

• Pratt DS 2005 Cholestasis and cholestatic syndromes. Curr. Opin. Gastroenterol. 21: 270-274.

• Redinger RN 2003 The role of the enterohepatic circulation of bile salts and nuclear hormone receptors in the regulation of cholesterol homeostasis: bile salts as ligands for nuclear hormone receptors. Can. J. Gastroenterol. 17: 265-271.

• Redinger RN 2003 The coming of age of our understanding of the enterohepatic circulation of bile salts. Am. J. Surg. 185: 168-172. *

• Rippin SJ, Hagenbuch B, Meier PJ, Stieger B 2001 Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes. Hepatology 33: 776-782. *

• Rius M, Hummel-Eisenbeiss J, Hofmann AF, Keppler D 2006 Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G640-G649. *

• Rizzo G, Renga B, Antonelli E, Passeri D, Pellicciari R, Fiorucci S 2005 The methyl transferase PRMT1 functions as co-activator of farnesoid X feceptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol. Pharmacol. 68: 551-558. *

• Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S 2005 Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Curr. Drug Targets Immune Endocr. Metabol. Disord. 5: 289-303.

• Roman ID, Fernandez-Moreno MD, Fueyo JA, Roma MG, Coleman R 2003 Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets. Toxicol. Sci. 71: 276-281. *

• Ros JE, Libbrecht L, Geuken M, Jansen PL, Roskams TA 2003 High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J. Pathol. 200: 553-560. *

• Ros JE, Roskams TA, Geuken M, Havinga R, Splinter PL, Petersen BE, LaRusso NF, van der Kolk DM, Kuipers F, Faber KN, Muller M, Jansen PL 2003 ATP binding cassette transporter gene expression in rat liver progenitor cells. Gut 52: 1060-1067. *

• Rose KA, Kostrubsky V, Sahi J 2006 Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes. Mol. Pharm. 3: 266-274. *

• Rost D, Kloeters-Plachky P, Stiehl A 2008 Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis. Eur. J. Med. Res. 13: 314-318.

• Ruiz ML, M Villanueva SS, Luquita MG, Sanchez-Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa JE, Vore M, Mottino AD, Catania VA 2005 Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2. Biochem. Pharmacol. 69: 531-539. *

• Rutherford AE, Pratt DS 2006 Cholestasis and cholestatic syndromes. Curr. Opin. Gastroenterol. 22: 209-214.

• Sakurai A, Kurata A, Onishi Y, Hirano H, Ishikawa T 2007 Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump. Expert Opin. Drug Saf. 6: 71-86.

• Saller R, Melzer J, Reichling J, Brignoli R, Meier R 2007 An updated systematic review of the pharmacology of silymarin. Forsch. Komplementarmed. 14: 70-80.

• Sampath J, Adachi M, Hatse S, Naesens L, Balzarini J, Flatley RM, Matherly LH, Schuetz JD 2002 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 4: E14. *

• Savander M, Ropponen A, Avela K, Weerasekera N, Cormand B, Hirvioja ML, Riikonen S, Ylikorkala O, Lehesjoki AE, Williamson C, Aittomaki K 2003 Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut 52: 1025-1029. *

• Scheimann AO, Strautnieks SS, Knisely AS, Byrne JA, Thompson RJ, Finegold MJ 2007 Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma. J. Pediatr. 150: 556-559. *

• Schmitt M, Kubitz R, Lizun S, Wettstein M, Haussinger D 2001 Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Hepatology 33: 509-518. *

• Schneider G, Paus TC, Kullak-Ublick GA, Meier PJ, Wienker TF, Lang T, van de Vondel P, Sauerbruch T, Reichel C 2007 Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. Hepatology 45: 150-158. *

• Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD 2001 Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J. Biol. Chem. 276: 39411-39418. *

• Serrano MA, Macias RI, Briz O, Monte MJ, Blazquez AG, Williamson C, Kubitz R, Marin JJ 2007 Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta. Placenta 28: 107-117.

• Shaffer EA 2002 Cholestasis: the ABCs of cellular mechanisms for impaired bile secretion - transporters and genes. Can. J. Gastroenterol. 16: 380-389.

• Shoda J, Kano M, Oda K, Kamiya J, Nimura Y, Suzuki H, Sugiyama Y, Miyazaki H, Todoroki T, Stengelin S, Kramer W, Matsuzaki Y, Tanaka N 2001 The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. Am. J. Gastroenterol. 96: 3368-3378. *

• Sidler Pfandler MA, Hochli M, Inderbitzin D, Meier PJ, Stieger B 2004 Small hepatocytes in culture develop polarized transporter expression and differentiation. J. Cell. Sci. 117: 4077-4087. *

• Siewert E, Dietrich CG, Lammert F, Heinrich PC, Matern S, Gartung C, Geier A 2004 Interleukin-6 regulates hepatic transporters during acute-phase response. Biochem. Biophys. Res. Commun. 322: 232-238. *

• Slitt AL, Allen K, Morrone J, Aleksunes LM, Chen C, Maher JM, Manautou JE, Cherrington NJ, Klaassen CD 2007 Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim. Biophys. Acta 1768: 637-647. *

• Snow KL, Moseley RH 2007 Effect of thiazolidinediones on bile acid transport in rat liver. Life Sci. 80: 732-740. *

• Song IS, Lee YM, Chung SJ, Shim CK 2003 Multiple alterations of canalicular membrane transport activities in rats with CCl(4)-induced hepatic injury. Drug Metab. Dispos. 31: 482-490. *

• Song X, Kaimal R, Yan B, Deng R 2008 Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression. J. Lipid Res. 49: 973-984. *

• St-Pierre MV, Stallmach T, Freimoser Grundschober A, Dufour JF, Serrano MA, Marin JJ, Sugiyama Y, Meier PJ 2004 Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R1505-R1516. *

• Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M 2006 Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc. Natl. Acad. Sci. U.S.A. 103: 11323-11328. *

• Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ 2000 Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 118: 422-430. *

• Stieger B, Meier Y, Meier PJ 2007 The bile salt export pump. Pflugers Arch. 453: 611-620. *

• Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Nemeth A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ 1998 A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat. Genet. 20: 233-238. *

• Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerova D, Rayner A, Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozcay F, Al-Hussaini HF, Bassas AF, Verkade HJ, Fischler B, Nemeth A, Kotalova R, Shneider BL, Cielecka-Kuszyk J, McClean P, et al 2008 Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology 134: 1203-1214. *

• Strautnieks SS, Byrne JA, Pawlikowska L, Nemeth A, Fischler B, Pawlowska J, Jankowska I, Jacquemin E, Hadchouel M, Sokal E, Wali S, Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ 2004 Genetic analysis of the bile salt export pump. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 45. June 18-19. *

• Suchy FJ, Ananthanarayanan M 2006 Bile salt excretory pump: biology and pathobiology. J. Pediatr. Gastroenterol. Nutr. 43 (1 Suppl. 1): S10-S16. *

• Sugiyama Y, Mita S, Maeda K, Suzuki H 2004 Analysis of vectorial transport of bile salts using human NTCP and human BSEP doubly expressing cells: comparative studies with rat Ntcp and rat Bsep. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 40. June 18-19. *

• SugiyamaY, Maeda K 2006 Assessment of inhibitory effect of many therapeutically important drugs on bile acid transport by NTCP, BSEP and other transporters. Falk Symposium 155. XIII FALK LIVER WEEK (Part I) XIX International Bile Acid Meeting. Bile Acids: Biological Actions and Clinical Relevance, October 6 - 7, 2006 Freiburg (Germany), p. 36-37. *

• Tachizawa H, Sano N, Takikawa H 2004 Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. J. Gastroenterol. Hepatol. 19: 1016-1022. *

• Takada T, Weiss M, Kretz O, Gross G, Sugiyama Y 2004 Hepatic transport of PKI166 - an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class - and its main metabolite ACU154. Drug Metab. Dispos. 32: 1272-1278. *

• Takahashi A, Hasegawa M, Sumazaki R, Suzuki M, Toki F, Suehiro T, Onigata K, Tomomasa T, Suzuki T, Matsui A, Morikawa A, Kuwano H 2007 Gradual improvement of liver function after administration of ursodeoxycholic acid in an infant with a novel ABCB11 gene mutation with phenotypic continuum between BRIC2 and PFIC2. Eur. J. Gastroenterol. Hepatol. 19: 942-946.

• Takikawa H 2002 Hepatobiliary transport of bile acids and organic anions. J. Hepatobiliary Pancreat. Surg. 9: 443-447.

• Tanaka Y, Chen C, Maher JM, Klaassen CD 2006 Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation 82: 258-266.

• Teng S, Piquette-Miller M 2005 The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J. Pharmacol. Exp. Ther. 312: 841-848. *

• Thompson R 2006 Genetics of hereditary cholestatic and metabolic liver diseases. Falk Symposium 156. XIII Falk Liver Week (Part II). GENETICS IN LIVER DISEASES, Freiburg (Germany), October 8-9, 2006, p. 41. *

• Thompson R, Strautnieks S 2001 BSEP: function and role in progressive familial intrahepatic cholestasis. Semin. Liver Dis. 21: 545-550. *

• Tomer G, Ananthanarayanan M, Weymann A, Balasubramanian N, Suchy FJ 2003 Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2. Pediatr. Res. 53: 288-294. *

• Tradtrantip L, Piyachaturawat P, Soroka C, Harry K, Mennone A, Mahagita C, Ballatori N, Boyer JL 2007 Phloracetophenone-induced choleresis in rats is mediated through Mrp2. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G66-G74. *

• Trauner M 2004 The nuclear bile acid receptor FXR as a novel therapeutic target in cholestatic liver diseases: hype or hope? Hepatology 40: 260-263. *

• Trauner M, Boyer JL 2004 Cholestatic syndromes. Curr. Opin. Gastroenterol. 20: 220-230.

• Trauner M, Boyer JL 2003 Bile salt transporters: molecular characterization, function, and regulation. Physiol. Rev. 83: 633-671. *

• Trauner M, Fickert P, Lammert F, Marschall HU 2004 ABCB4 gene mutations and primary sclerosing cholangitis. Gastroenterology 126: 1222-1223. *

• Trauner M, Fickert P, Wagner M, Zollner G 2004 Adaptive hepatobiliary transporter regulation by ursodeoxycholic acid. Falk Symposium 141. XVIII International Bile Acid Meeting: Bile Acid Biology and its Therapeutic Implications. Stockholm (Sweden). p. 48-49. June 18-19. *

• Tsuboi K, Tazuma S, Ochi H, Chayama K 2003 Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. Hepatol. Res. 25: 38-47. *

• Turncliff RZ, Meier PJ, Brouwer KL 2004 Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes. Drug Metab. Dispos. 32: 834-839. *

• Turncliff RZ, Tian X, Brouwer KL 2006 Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes. Biochem. Pharmacol. 71: 1520-1529. *

• Urquhart BL, Tirona RG, Kim RB 2007 Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J. Clin. Pharmacol. 47: 566-578. *

• Vallejo M, Briz O, Serrano MA, Monte MJ, Marin JJ 2006 Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. J. Hepatol. 44: 1150-1157. *

• van Erpecum KJ 2005 Biliary lipids, water and cholesterol gallstones. Biol. Cell. 97: 815-822. *

• Van Mil SW, Van Der Woerd WL, Van Der Brugge G, Sturm E, Jansen PL, Bull LN, Van Den Berg IE, Berger R, Houwen RH, Klomp LW 2004 Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology 127: 379-384. *

• vanBerge-Henegouwen GP, Venneman NG, Portincasa P, Kosters A, van Erpecum KJ, Groen AK 2004 Relevance of hereditary defects in lipid transport proteins for the pathogenesis of cholesterol gallstone disease. Scand. J. Gastroenterol. Suppl. 241: 60-69. *

• Vos TA, Ros JE, Havinga R, Moshage H, Kuipers F, Jansen PL, Muller M 1999 Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats. Hepatology 29: 1833-1839. *

• Wagner M, Fickert P, Zollner G, Fuchsbichler A, Silbert D, Tsybrovskyy O, Zatloukal K, Guo GL, Schuetz JD, Gonzalez FJ, Marschall HU, Denk H, Trauner M 2003 Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 125: 825-838. *

• Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C, Zatloukal K, Denk H, Trauner M 2005 CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology 42: 420-430. *

• Wagner M, Zollner G, Fickert P, Gumhold J, Silbert D, Fuchsbichler A, Gujral J, Zatloukal K, Denk H, Jaeschke H, Trauner M 2007 Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress. Drug Metab. Dispos. 35: 1694-1699. *

• Wakabayashi Y, Lippincott-Schwartz J, Arias IM 2004 Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11 positive endosomes. Mol. Biol. Cell 15: 3485-3496. *

• Wang EJ, Casciano CN, Clement RP, Johnson WW 2003 Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm. Res. 20: 537-544. *

• Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M 2008 Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology Jul 16 [Epub ahead of print].

• Wang L, Soroka CJ, Boyer JL 2002 The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. J. Clin. Invest. 110: 965-972. *

• Wang R, Lam P, Liu L, Forrest D, Yousef IM, Mignault D, Phillips MJ, Ling V 2003 Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein. Hepatology 38: 1489-1499. *

• Wang R, Salem M, Yousef IM, Tuchweber B, Lam P, Childs SJ, Helgason CD, Ackerley C, Phillips MJ, Ling V 2001 Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc. Natl. Acad. Sci. U.S.A. 98: 2011-2016. *

• Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL 2006 Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology 131: 878-884. *

• Warskulat U, Kubitz R, Wettstein M, Stieger B, Meier PJ, Haussinger D 1999 Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes. Biol. Chem. 380: 1273-1279. *

• Wiwanitkit V 2007 Identification of mutation-prone points in bile salt export pump. HPB (Oxford) 9: 444-446. *

• Wolters H, Elzinga BM, Baller JF, Boverhof R, Schwarz M, Stieger B, Verkade HJ, Kuipers F 2002 Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. J. Hepatol. 37: 556-563. *

• Xia CQ, Milton MN, Gan LS 2007 Evaluation of drug-transporter interactions using in vitro and in vivo models. Curr. Drug Metab. 8: 341-363.

• Xu G, Pan LX, Erickson SK, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G 2002 Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits. J. Lipid Res. 43: 45-50. *

• Xu G, Pan LX, Li H, Forman BM, Erickson SK, Shefer S, Bollineni J, Batta AK, Christie J, Wang TH, Michel J, Yang S, Tsai R, Lai L, Shimada K, Tint GS, Salen G 2002 Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits. J. Biol. Chem. 277: 50491-50496. *

• Xu G, Pan LX, Li H, Shang Q, Honda A, Shefer S, Bollineni J, Matsuzaki Y, Tint GS, Salen G 2004 Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor (FXR) is not activated. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G730-G735. *

• Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M 2006 Estrogen receptor alpha mediates 17alpha-ethynylestradiol-causing hepatotoxicity. J. Biol. Chem. 281: 16625-16631. *

• Yu J, Lo JL, Huang L, Zhao A, Metzger E, Adams A, Meinke PT, Wright SD, Cui J 2002 Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J. Biol. Chem. 277: 31441-31447. *

• Zhang Y, Kast-Woelbern HR, Edwards PA 2003 Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J. Biol. Chem. 278: 104-110. *

• Zhao A, Yu J, Lew JL, Huang L, Wright SD, Cui J 2004 Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. DNA Cell. Biol. 23: 519-526. *

• Zinchuk V, Zinchuk O, Akimaru K, Moriya F, Okada T 2007 Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat. Histochem. Cell Biol. 127: 503-512. *

• Zinchuk V, Zinchuk O, Okada T 2005 Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Microsc. Res. Tech. 67: 65-70. *

• Zinchuk VS, Okada T, Akimaru K, Seguchi H 2002 Asynchronous expression and colocalization of Bsep and Mrp2 during development of rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G540-G548. *

• Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M 2003 Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J. Hepatol. 39: 480-488. *

• Zollner G, Fickert P, Silbert D, Fuchsbichler A, Marschall HU, Zatloukal K, Denk H, Trauner M 2003 Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J. Hepatol. 38: 717-727. *

• Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, Ferenci P, Stauber RE, Krejs GJ, Denk H, Zatloukal K, Trauner M 2001 Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 33: 633-646. *

• Zollner G, Wagner M, Fickert P, Silbert D, Fuchsbichler A, Zatloukal K, Denk H, Trauner M 2005 Hepatobiliary transporter expression in human hepatocellular carcinoma. Liver Int. 25: 367-379. *

• Zou SL, Liu J, Lan Y, Cheng H, Gan XL 2008 Effects of farnesoid X receptor ligand on the metabolism of bile acids in rats with estrogen-induced intrahepatic cholestasis of pregnancy. Zhonghua Gan Zang Bing Za Zhi 16: 383-386.

Number of references = 347

www psc-literature.org