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Scientific Literature, ATG16L1
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Achkar JP 2008 IL23R and ATG16L1 SNPs in IBD: alphabet soup or something more?
Am. J. Gastroenterol. 103: 628-630.
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Achkar JP, Duerr R 2008 The expanding universe of inflammatory bowel disease genetics.
Curr. Opin. Gastroenterol. 24: 429-434.
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Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H 2007 Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.
Gut 56: 1171-1173.
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Baptista ML, Amarante H, Picheth G, Sdepanian VL, Peterson N, Babasukumar U, Lima HC, Kugathasan S 2008 CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.
Inflamm. Bowel Dis. 14: 674-679.
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Cummings JR, Cooney R, Pathan S, Anderson CA, Barrett JC, Beckly J, Geremia A, Hancock L, Guo C, Ahmad T, Cardon LR, Jewell DP 2007 Confirmation of the role of ATG16l1 as a Crohn's disease susceptibility gene.
Inflamm. Bowel Dis. 13: 941-946.
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Duerr RH 2007 Genome-wide association studies herald a new era of rapid discoveries in inflammatory bowel disease research.
Gastroenterology 132: 2045-2049.
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Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, et al 2008 Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Nat. Genet. 40: 710-712.
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Fowler EV, Doecke J, Simms LA, Zhao ZZ, Webb PM, Hayward NK, Whiteman DC, Florin TH, Montgomery GW, Cavanaugh JA, Radford-Smith GL 2008 ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity.
Am. J. Gastroenterol. Jul 30 [Epub ahead of print].
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Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Torok HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Goke B, Ochsenkuhn T, Mussack T, Folwaczny M, Muller-Myhsok B, Brand S 2008 The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
Am. J. Gastroenterol. 103: 682-691.
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Grant SF, Baldassano RN, Hakonarson H 2008 Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene.
Expert Rev. Mol. Diagn. 8: 199-207.
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Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S 2007 A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
Nat. Genet. 39: 207-211.
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Hemminki K, Bermejo JL, Hemminki K, Forsti A 2008 Genetics of inflammatory bowel disease: population aspects.
Gastroenterology 134: 2190-2191.
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Lakatos PL, Szamosi T, Szilvasi A, Molnar E, Lakatos L, Kovacs A, Molnar T, Altorjay I, Papp M, Tulassay Z, Miheller P, Papp J; The Hungarian IBD Study Group, Tordai A, Andrikovics H 2008 ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients.
Dig. Liver Dis. May 20 [Epub ahead of print].
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Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B, Gut I, Heath S, Foglio M, Liang L, Laukens D, Mni M, Zelenika D, Van Gossum A, Rutgeerts P, Belaiche J, Lathrop M, Georges M 2007 Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
PLoS Genet. 3: e58.
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Massey DC, Parkes M 2007 Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.
Autophagy 3: 649-651.
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Okazaki T, Wang MH, Rawsthorne P, Sargent M, Datta LW, Shugart YY, Bernstein CN, Brant SR 2008 Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: evidence of gene-gene interactions.
Inflamm. Bowel Dis. Jun 2 [Epub ahead of print].
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Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, Bagnall R, Mirza MM, Sanderson J, Forbes A, Mansfield JC, Lewis CM, Schreiber S, Mathew CG 2007 A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
Gastroenterology 132: 1665-1671.
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Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, et al 2007 Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
Nat. Genet. 39: 596-604.
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Roberts RL, Gearry RB, Hollis-Moffatt JE, Miller AL, Reid J, Abkevich V, Timms KM, Gutin A, Lanchbury JS, Merriman TR, Barclay ML, Kennedy MA 2007 IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
Am. J. Gastroenterol. 102: 2754-2761.
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Sheikh S, Uno J, Matsuoka K, Plevy S 2008 Abnormal mucosal immune response to altered bacterial flora following restorative proctocolectomy in patients with ulcerative colitis: serologic measures, immunogenetics, and clinical correlations.
Clin. Immunol. 127: 270-279.
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Van Limbergen J, Russell RK, Nimmo ER, Drummond HE, Smith L, Anderson NH, Davies G, Gillett PM, McGrogan P, Weaver LT, Bisset WM, Mahdi G, Arnott ID, Wilson DC, Satsangi J 2008 Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe.
Inflamm. Bowel Dis. 14: 338-346.
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Van Limbergen J, Russell RK, Nimmo ER, Satsangi J 2007 The genetics of inflammatory bowel disease.
Am. J. Gastroenterol. 102: 2820-2831.
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Weersma RK, Zhernakova A, Nolte IM, Lefebvre C, Rioux JD, Mulder F, van Dullemen HM, Kleibeuker JH, Wijmenga C, Dijkstra G 2008 ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
Am. J. Gastroenterol. 103: 621-627.
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Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A 2007 Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.
J. Hum. Genet. 52: 575-583.
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Zhi J, Zhi FC, Chen ZY, Yao GP, Guan J, Lin Y, Zhang YC 2008 Correlation of the autophagosome gene ATG16L1 polymorphism and inflammatory bowel disease.
Nan Fang Yi Ke Da Xue Xue Bao 28: 649-651.
Number of references = 25
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David and Judy Rhodes
Last Update: 8/5/2008
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